"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "Reactome Pathways" "WikiPathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 52C) / (126, 52C)" "Abundance Ratio: (127C, 52C) / (126, 52C)" "Abundance Ratio: (128N, 52C) / (126, 52C)" "Abundance Ratio: (128C, 52C) / (126, 52C)" "Abundance Ratio: (129N, 52C) / (126, 52C)" "Abundance Ratio: (129C, 52C) / (126, 52C)" "Abundance Ratio: (130N, 52C) / (126, 52C)" "Abundance Ratio: (130C, 52C) / (126, 52C)" "Abundance Ratio: (131, 52C) / (126, 52C)" "Abundances (Grouped): 126, 52C" "Abundances (Grouped): 127N, 52C" "Abundances (Grouped): 127C, 52C" "Abundances (Grouped): 128N, 52C" "Abundances (Grouped): 128C, 52C" "Abundances (Grouped): 129N, 52C" "Abundances (Grouped): 129C, 52C" "Abundances (Grouped): 130N, 52C" "Abundances (Grouped): 130C, 52C" "Abundances (Grouped): 131, 52C" "Abundances (Grouped) CV [%]: 126, 52C" "Abundances (Grouped) CV [%]: 127N, 52C" "Abundances (Grouped) CV [%]: 127C, 52C" "Abundances (Grouped) CV [%]: 128N, 52C" "Abundances (Grouped) CV [%]: 128C, 52C" "Abundances (Grouped) CV [%]: 129N, 52C" "Abundances (Grouped) CV [%]: 129C, 52C" "Abundances (Grouped) CV [%]: 130N, 52C" "Abundances (Grouped) CV [%]: 130C, 52C" "Abundances (Grouped) CV [%]: 131, 52C" "Abundance: F4: 126, Sample, 52C" "Abundance: F4: 127N, Sample, 52C" "Abundance: F4: 127C, Sample, 52C" "Abundance: F4: 128N, Sample, 52C" "Abundance: F4: 128C, Sample, 52C" "Abundance: F4: 129N, Sample, 52C" "Abundance: F4: 129C, Sample, 52C" "Abundance: F4: 130N, Sample, 52C" "Abundance: F4: 130C, Sample, 52C" "Abundance: F4: 131, Sample, 52C" "Abundances Count: F4: 126, Sample, 52C" "Abundances Count: F4: 127N, Sample, 52C" "Abundances Count: F4: 127C, Sample, 52C" "Abundances Count: F4: 128N, Sample, 52C" "Abundances Count: F4: 128C, Sample, 52C" "Abundances Count: F4: 129N, Sample, 52C" "Abundances Count: F4: 129C, Sample, 52C" "Abundances Count: F4: 130N, Sample, 52C" "Abundances Count: F4: 130C, Sample, 52C" "Abundances Count: F4: 131, Sample, 52C" "Found in Sample: [S31] F4: 126, Sample, 52C" "Found in Sample: [S32] F4: 127N, Sample, 52C" "Found in Sample: [S33] F4: 127C, Sample, 52C" "Found in Sample: [S34] F4: 128N, Sample, 52C" "Found in Sample: [S35] F4: 128C, Sample, 52C" "Found in Sample: [S36] F4: 129N, Sample, 52C" "Found in Sample: [S37] F4: 129C, Sample, 52C" "Found in Sample: [S38] F4: 130N, Sample, 52C" "Found in Sample: [S39] F4: 130C, Sample, 52C" "Found in Sample: [S40] F4: 131, Sample, 52C" "# Protein Groups" "Modifications" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "1649.795" "63" "132" "614" "101" "1960" "226.4" "5.60" "2483.45" "132" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "17" "30" "0.964" "0.947" "1.027" "1.026" "1.050" "1.123" "1.130" "1.130" "0.666" "73557.7" "70942.4" "69670.8" "75509.4" "75487.5" "77203.9" "82595.1" "83101.2" "83108.7" "48987.4" "" "" "" "" "" "" "" "" "" "" "65229.5" "58765.1" "60791.1" "56471.0" "62946.4" "70920.4" "69806.0" "68689.0" "76222.1" "48987.4" "157" "157" "157" "157" "157" "157" "157" "157" "157" "157" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "1159.160" "37" "163" "316" "163" "4646" "532.1" "6.40" "1219.83" "163" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Neutrophil degranulation; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "24" "0" "0.918" "0.926" "1.000" "0.974" "0.903" "1.310" "1.214" "1.179" "1.626" "27412.4" "25170.1" "25387.2" "27404.6" "26693.4" "24757.5" "35914.8" "33276.0" "32324.1" "44577.7" "" "" "" "" "" "" "" "" "" "" "24308.7" "20849.6" "22151.6" "20495.0" "22258.6" "22742.5" "30353.7" "27505.0" "29645.6" "44577.7" "133" "133" "133" "133" "133" "133" "133" "133" "133" "133" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "1141.821" "38" "151" "337" "151" "4128" "468.8" "7.12" "1284.24" "151" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "13" "0" "1.006" "1.027" "1.065" "1.074" "1.079" "1.288" "1.266" "1.225" "1.430" "29104.3" "29280.7" "29899.8" "30984.9" "31268.8" "31415.7" "37473.2" "36840.9" "35664.1" "41613.7" "" "" "" "" "" "" "" "" "" "" "25809.1" "24254.7" "26089.0" "23172.6" "26074.0" "28858.8" "31670.9" "30451.6" "32708.9" "41613.7" "142" "142" "142" "142" "142" "142" "142" "142" "142" "142" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "1110.033" "59" "129" "285" "129" "2472" "284.4" "5.35" "1189.21" "129" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "RAF/MAP kinase cascade; Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins" "Fas ligand pathway and stress induction of heat shock proteins" "12" "0" "0.993" "0.989" "0.971" "0.991" "1.036" "0.958" "0.968" "0.950" "0.575" "34688.8" "34439.7" "34323.1" "33671.7" "34378.7" "35925.6" "33239.3" "33572.6" "32950.3" "19941.9" "" "" "" "" "" "" "" "" "" "" "30761.3" "28528.1" "29948.6" "25182.0" "28667.2" "33001.6" "28092.5" "27750.1" "30220.0" "19941.9" "125" "125" "125" "125" "125" "125" "125" "125" "125" "125" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "1105.595" "57" "117" "258" "117" "2364" "274.4" "5.57" "1083.42" "117" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "1.028" "1.019" "1.006" "1.021" "1.049" "0.965" "0.999" "0.990" "0.606" "29306.5" "30113.9" "29863.2" "29475.9" "29923.0" "30749.1" "28287.4" "29267.5" "29026.1" "17748.1" "" "" "" "" "" "" "" "" "" "" "25988.4" "24944.9" "26057.1" "22044.1" "24951.8" "28246.5" "23907.4" "24191.6" "26621.0" "17748.1" "114" "114" "114" "114" "114" "114" "114" "114" "114" "114" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "899.939" "46" "91" "248" "91" "2511" "273.3" "6.44" "1022.66" "91" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "18" "0" "1.002" "1.010" "0.990" "0.991" "0.952" "1.062" "1.006" "1.003" "1.195" "23107.9" "23156.8" "23341.4" "22881.0" "22888.9" "22002.5" "24545.9" "23257.1" "23175.4" "27618.3" "" "" "" "" "" "" "" "" "" "" "20491.6" "19181.9" "20366.5" "17111.9" "19086.2" "20211.7" "20745.2" "19223.6" "21255.0" "27618.3" "91" "91" "91" "91" "91" "91" "91" "91" "91" "91" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "731.288" "45" "94" "172" "92" "2541" "269.6" "6.07" "673.00" "94" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "18" "2" "1.035" "0.972" "0.974" "0.973" "0.924" "0.978" "0.812" "0.970" "4.021" "10856.4" "11237.9" "10553.1" "10570.0" "10558.3" "10026.0" "10615.1" "8810.7" "10530.8" "43653.4" "" "" "" "" "" "" "" "" "" "" "9627.2" "9308.9" "9208.1" "7905.0" "8804.2" "9210.0" "8971.5" "7282.7" "9658.2" "43653.4" "76" "76" "76" "76" "76" "76" "76" "76" "76" "76" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "718.961" "81" "49" "603" "48" "531" "57.9" "7.84" "2412.40" "49" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Neutrophil degranulation" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "10" "0" "1.045" "1.068" "1.045" "1.072" "1.066" "1.073" "1.077" "1.062" "0.517" "56468.6" "59022.4" "60316.8" "58985.1" "60517.4" "60201.2" "60599.3" "60827.9" "59974.3" "29194.6" "" "" "" "" "" "" "" "" "" "" "50075.2" "48891.3" "52629.4" "44113.1" "50463.3" "55301.5" "51216.1" "50278.5" "55004.7" "29194.6" "54" "54" "54" "54" "54" "54" "54" "54" "54" "54" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "692.594" "77" "41" "476" "41" "573" "61.0" "5.87" "2012.32" "41" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Mitochondrial protein degradation; Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "6" "0" "1.027" "1.055" "1.030" "1.041" "1.023" "1.040" "1.057" "1.031" "0.457" "45205.7" "46409.3" "47702.1" "46580.2" "47077.7" "46265.4" "47036.3" "47798.3" "46624.8" "20648.1" "" "" "" "" "" "" "" "" "" "" "40087.4" "38443.2" "41622.4" "34835.8" "39256.4" "42499.9" "39753.1" "39508.6" "42761.3" "20648.1" "50" "50" "50" "50" "50" "50" "50" "50" "50" "50" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "680.560" "61" "49" "254" "49" "806" "89.3" "5.26" "953.86" "49" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "Aggrephagy; Neutrophil degranulation; HSF1 activation; RHOH GTPase cycle; E3 ubiquitin ligases ubiquitinate target proteins; ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "21" "0" "1.019" "1.028" "1.048" "1.058" "1.039" "1.028" "1.069" "1.041" "0.474" "27724.8" "28256.1" "28507.4" "29059.6" "29321.4" "28813.5" "28502.4" "29633.0" "28860.8" "13142.8" "" "" "" "" "" "" "" "" "" "" "24585.8" "23405.9" "24874.1" "21732.7" "24450.1" "26468.4" "24089.0" "24493.8" "26469.3" "13142.8" "59" "59" "59" "59" "59" "59" "59" "59" "59" "59" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "676.570" "80" "36" "282" "36" "535" "57.5" "6.46" "1136.68" "36" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "10" "0" "1.030" "1.013" "1.033" "1.062" "1.011" "1.035" "1.056" "0.986" "0.633" "28660.3" "29511.3" "29038.4" "29619.7" "30434.2" "28980.7" "29670.6" "30258.4" "28270.5" "18128.6" "" "" "" "" "" "" "" "" "" "" "25415.4" "24445.7" "25337.5" "22151.6" "25378.0" "26622.0" "25076.4" "25010.7" "25927.9" "18128.6" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "665.258" "62" "48" "518" "19" "724" "83.2" "5.03" "1914.80" "48" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Neutrophil degranulation; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "25" "14" "0.980" "1.071" "0.952" "0.989" "1.018" "1.062" "1.068" "1.170" "1.213" "22511.0" "22058.8" "24114.1" "21438.6" "22268.0" "22913.8" "23898.7" "24050.2" "26327.1" "27314.4" "" "" "" "" "" "" "" "" "" "" "19962.3" "18272.4" "21040.7" "16033.2" "18568.5" "21048.9" "20198.2" "19879.2" "24145.6" "27314.4" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "648.637" "53" "55" "250" "55" "1101" "120.8" "7.33" "912.63" "55" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "10" "0" "1.039" "1.041" "1.031" "1.042" "1.021" "1.044" "1.077" "0.998" "0.557" "31625.0" "32850.2" "32914.6" "32598.2" "32950.6" "32280.3" "33022.1" "34059.6" "31561.7" "17629.6" "" "" "" "" "" "" "" "" "" "" "28044.4" "27211.5" "28719.6" "24379.1" "27476.4" "29653.1" "27909.0" "28152.7" "28946.4" "17629.6" "64" "64" "64" "64" "64" "64" "64" "64" "64" "64" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "645.011" "55" "49" "438" "48" "858" "95.3" "6.83" "1694.60" "49" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "9" "1" "1.035" "1.053" "1.038" "1.067" "1.044" "1.003" "1.005" "0.964" "0.507" "52722.8" "54586.6" "55515.9" "54721.5" "56244.9" "55026.8" "52866.9" "53006.7" "50803.4" "26737.4" "" "" "" "" "" "" "" "" "" "" "46753.5" "45216.8" "48440.4" "40924.5" "46900.6" "50548.3" "44681.0" "43813.8" "46593.7" "26737.4" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "634.830" "75" "28" "974" "9" "375" "41.7" "5.48" "3913.22" "28" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; UCH proteinases; Clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases Activate Formins; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RHOF GTPase cycle; B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "157" "23" "1.000" "0.991" "1.016" "1.033" "1.083" "1.014" "1.036" "1.013" "0.558" "84123.5" "84162.3" "83330.6" "85486.3" "86877.9" "91129.1" "85338.4" "87168.2" "85239.6" "46923.2" "" "" "" "" "" "" "" "" "" "" "74599.0" "69715.9" "72710.0" "63932.4" "72444.4" "83712.3" "72124.6" "72050.6" "78176.4" "46923.2" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "634.443" "63" "52" "532" "31" "732" "84.6" "5.02" "1869.22" "52" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Neutrophil degranulation; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "71" "21" "0.962" "1.026" "0.967" "0.976" "1.019" "1.049" "1.060" "1.102" "1.162" "50896.7" "48960.5" "52200.4" "49231.8" "49666.4" "51863.4" "53373.2" "53937.2" "56083.7" "59153.2" "" "" "" "" "" "" "" "" "" "" "45134.1" "40556.5" "45547.4" "36818.9" "41415.0" "47642.3" "45108.9" "44582.9" "51436.4" "59153.2" "57" "57" "57" "57" "57" "57" "57" "57" "57" "57" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "631.943" "67" "57" "238" "57" "911" "104.8" "5.44" "933.16" "57" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Platelet degranulation ; Nephrin family interactions" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "9" "0" "1.010" "1.026" "1.028" "1.046" "1.047" "1.044" "1.079" "1.053" "0.506" "23977.4" "24212.5" "24592.1" "24645.1" "25070.9" "25105.6" "25043.2" "25871.6" "25242.9" "12125.8" "" "" "" "" "" "" "" "" "" "" "21262.7" "20056.4" "21457.8" "18431.3" "20905.7" "23062.3" "21165.5" "21384.7" "23151.2" "12125.8" "57" "57" "57" "57" "57" "57" "57" "57" "57" "57" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "613.611" "40" "88" "155" "86" "2363" "267.1" "5.02" "637.94" "88" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "" "29" "2" "0.983" "0.974" "0.915" "0.917" "0.942" "0.846" "0.840" "0.901" "1.165" "20773.8" "20413.6" "20235.7" "19017.8" "19054.9" "19559.4" "17578.4" "17453.5" "18719.0" "24208.2" "" "" "" "" "" "" "" "" "" "" "18421.8" "16909.6" "17656.6" "14222.8" "15889.2" "17967.5" "14856.5" "14426.5" "17167.9" "24208.2" "84" "84" "84" "84" "84" "84" "84" "84" "84" "84" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "604.963" "68" "53" "215" "49" "840" "94.3" "5.19" "819.30" "53" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "3" "5" "1.009" "1.004" "0.892" "0.894" "0.930" "0.909" "0.934" "0.941" "1.004" "29863.1" "30138.5" "29979.4" "26644.2" "26698.1" "27782.0" "27138.9" "27893.8" "28086.9" "29993.7" "" "" "" "" "" "" "" "" "" "" "26482.0" "24965.3" "26158.4" "19926.3" "22262.6" "25520.9" "22936.7" "23056.2" "25759.5" "29993.7" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "604.946" "81" "40" "218" "40" "592" "64.6" "6.71" "923.52" "40" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "One-carbon metabolism" "3" "0" "1.060" "1.112" "1.046" "1.088" "1.091" "1.037" "1.105" "1.141" "0.564" "25739.2" "27296.1" "28626.3" "26931.7" "27998.0" "28087.5" "26696.2" "28432.4" "29365.5" "14525.6" "" "" "" "" "" "" "" "" "" "" "22825.0" "22610.8" "24977.8" "20141.3" "23346.5" "25801.5" "22562.5" "23501.4" "26932.2" "14525.6" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "596.095" "66" "41" "424" "32" "627" "70.2" "5.43" "1556.64" "41" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "9" "1.006" "1.005" "1.035" "1.025" "1.019" "1.020" "1.023" "0.993" "0.616" "45969.8" "46267.1" "46216.8" "47590.3" "47109.2" "46841.9" "46870.0" "47049.5" "45641.9" "28334.1" "" "" "" "" "" "" "" "" "" "" "40765.0" "38325.4" "40326.4" "35591.2" "39282.7" "43029.5" "39612.6" "38889.7" "41859.9" "28334.1" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "590.217" "60" "40" "497" "23" "646" "70.9" "5.52" "1822.37" "40" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Clathrin-mediated endocytosis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase; Respiratory syncytial virus genome transcription" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "27" "17" "0.975" "0.992" "0.970" "0.948" "0.995" "0.916" "0.933" "0.957" "0.602" "57126.3" "55712.8" "56665.6" "55411.3" "54161.1" "56866.0" "52328.1" "53313.4" "54671.5" "34398.5" "" "" "" "" "" "" "" "" "" "" "50658.4" "46149.7" "49443.5" "41440.3" "45163.0" "52237.7" "44225.6" "44067.3" "50141.2" "34398.5" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "578.460" "71" "29" "843" "28" "335" "36.0" "8.46" "3261.83" "29" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Glycolysis; Gluconeogenesis" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "16" "1" "1.003" "0.990" "0.947" "0.962" "0.982" "0.924" "0.959" "1.001" "0.504" "85073.2" "85334.3" "84212.5" "80592.7" "81877.5" "83565.0" "78601.5" "81583.5" "85193.0" "42917.7" "" "" "" "" "" "" "" "" "" "" "75441.2" "70686.7" "73479.5" "60272.7" "68274.8" "76763.8" "66430.8" "67434.5" "78133.6" "42917.7" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "559.929" "46" "63" "182" "63" "1616" "183.1" "7.75" "689.77" "63" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "13" "0" "0.967" "0.993" "1.022" "1.016" "0.992" "1.000" "1.038" "1.018" "0.650" "20258.3" "19586.5" "20118.0" "20706.0" "20587.9" "20102.3" "20253.7" "21021.7" "20617.5" "13157.8" "" "" "" "" "" "" "" "" "" "" "17964.6" "16224.5" "17554.0" "15485.3" "17167.5" "18466.2" "17117.6" "17375.9" "18909.1" "13157.8" "67" "67" "67" "67" "67" "67" "67" "67" "67" "67" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "554.004" "56" "69" "177" "69" "1233" "143.1" "7.64" "651.57" "69" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "Estrogen-dependent gene expression; Separation of Sister Chromatids; Meiotic synapsis; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "22" "0" "0.995" "1.004" "0.955" "0.967" "0.972" "0.934" "0.973" "0.966" "0.683" "20237.2" "20133.3" "20322.3" "19320.9" "19559.5" "19680.3" "18892.4" "19698.6" "19549.2" "13825.3" "" "" "" "" "" "" "" "" "" "" "17945.9" "16677.5" "17732.2" "14449.5" "16310.0" "18078.5" "15967.1" "16282.2" "17929.3" "13825.3" "68" "68" "68" "68" "68" "68" "68" "68" "68" "68" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "550.200" "50" "60" "172" "60" "1217" "141.5" "7.18" "691.34" "60" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "15" "0" "1.000" "1.007" "1.005" "1.003" "1.020" "0.962" "0.997" "0.977" "0.759" "22003.1" "22010.2" "22164.5" "22117.3" "22064.4" "22437.1" "21166.8" "21928.4" "21490.1" "16709.6" "" "" "" "" "" "" "" "" "" "" "19511.9" "18232.1" "19339.6" "16540.8" "18398.7" "20611.0" "17889.3" "18125.4" "19709.4" "16709.6" "64" "64" "64" "64" "64" "64" "64" "64" "64" "64" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "548.167" "86" "36" "412" "31" "417" "44.6" "8.10" "1655.91" "36" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "13" "6" "1.021" "1.049" "1.017" "1.047" "1.059" "1.049" "1.071" "1.075" "0.547" "43155.1" "44043.5" "45272.7" "43885.3" "45190.7" "45692.7" "45283.5" "46212.5" "46406.2" "23592.5" "" "" "" "" "" "" "" "" "" "" "38269.0" "36483.4" "39502.7" "32820.4" "37682.9" "41973.9" "38271.8" "38197.8" "42560.9" "23592.5" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "542.822" "65" "39" "227" "38" "679" "73.6" "6.16" "898.56" "39" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein degradation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "7" "0" "0.984" "1.047" "0.969" "1.002" "1.027" "1.004" "1.066" "1.104" "0.508" "27841.6" "27391.9" "29152.2" "26983.0" "27910.4" "28584.8" "27947.9" "29691.0" "30744.8" "14131.1" "" "" "" "" "" "" "" "" "" "" "24689.4" "22690.1" "25436.7" "20179.7" "23273.5" "26258.3" "23620.4" "24541.7" "28197.2" "14131.1" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "533.913" "71" "33" "183" "33" "543" "59.3" "7.65" "774.52" "33" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "9" "0" "1.035" "1.049" "1.044" "1.071" "1.035" "1.068" "1.067" "1.030" "0.540" "20543.5" "21254.8" "21548.8" "21455.3" "22005.3" "21263.2" "21949.0" "21926.5" "21156.2" "11090.9" "" "" "" "" "" "" "" "" "" "" "18217.6" "17606.4" "18802.4" "16045.8" "18349.4" "19532.6" "18550.4" "18123.8" "19403.1" "11090.9" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "531.296" "76" "29" "454" "11" "434" "47.1" "7.39" "1792.66" "29" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "9" "19" "1.016" "1.035" "0.994" "1.019" "1.016" "1.008" "1.032" "1.090" "0.503" "50597.8" "51397.0" "52391.1" "50318.0" "51537.0" "51425.4" "51006.0" "52192.8" "55172.1" "25449.0" "" "" "" "" "" "" "" "" "" "" "44869.1" "42574.7" "45713.8" "37631.2" "42974.9" "47239.9" "43108.2" "43141.1" "50600.3" "25449.0" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "521.092" "58" "36" "256" "33" "654" "72.3" "5.16" "1072.09" "36" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "14" "0" "1.039" "1.029" "1.045" "1.049" "1.046" "1.066" "1.085" "1.098" "0.480" "26015.3" "27026.8" "26773.7" "27192.9" "27301.8" "27220.9" "27733.5" "28236.7" "28572.8" "12487.0" "" "" "" "" "" "" "" "" "" "" "23069.8" "22387.7" "23361.4" "20336.7" "22766.0" "25005.4" "23439.3" "23339.6" "26205.2" "12487.0" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "517.041" "42" "56" "136" "56" "1675" "191.5" "5.69" "578.77" "56" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "25" "0" "0.979" "0.990" "0.948" "0.921" "0.882" "1.092" "1.029" "1.067" "2.259" "11395.3" "11159.1" "11277.4" "10803.8" "10496.7" "10054.5" "12445.3" "11728.5" "12157.1" "25741.3" "" "" "" "" "" "" "" "" "" "" "10105.1" "9243.7" "9840.1" "8079.8" "8752.8" "9236.2" "10518.3" "9694.5" "11149.7" "25741.3" "54" "54" "54" "54" "54" "54" "54" "54" "54" "54" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "500.244" "49" "51" "172" "51" "1152" "120.9" "5.43" "641.88" "51" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "2" "0" "0.964" "0.978" "0.944" "0.957" "0.954" "0.916" "0.962" "0.957" "0.482" "25352.4" "24446.9" "24792.2" "23923.6" "24253.5" "24181.4" "23214.3" "24390.4" "24252.1" "12218.2" "" "" "" "" "" "" "" "" "" "" "22482.0" "20250.6" "21632.4" "17891.7" "20224.1" "22213.3" "19619.8" "20160.4" "22242.5" "12218.2" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "496.712" "68" "35" "200" "34" "541" "59.6" "5.66" "773.44" "35" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "1" "0.988" "0.991" "0.975" "1.016" "1.009" "0.994" "1.019" "0.961" "0.511" "23317.3" "23031.6" "23115.3" "22733.4" "23680.2" "23526.3" "23166.4" "23764.5" "22410.4" "11926.4" "" "" "" "" "" "" "" "" "" "" "20677.3" "19078.3" "20169.2" "17001.6" "19746.1" "21611.6" "19579.3" "19643.0" "20553.4" "11926.4" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "488.254" "63" "48" "150" "48" "808" "90.9" "5.77" "565.60" "48" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "11" "0" "0.972" "0.985" "1.002" "1.002" "0.938" "0.995" "1.045" "1.008" "0.738" "15515.0" "15078.1" "15274.7" "15550.6" "15545.6" "14556.9" "15444.5" "16209.1" "15638.0" "11452.7" "" "" "" "" "" "" "" "" "" "" "13758.4" "12490.0" "13327.9" "11629.8" "12962.9" "13372.1" "13053.1" "13398.0" "14342.2" "11452.7" "49" "49" "49" "49" "49" "49" "49" "49" "49" "49" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "478.120" "77" "39" "218" "39" "548" "59.6" "5.60" "785.24" "39" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "1.020" "1.035" "1.026" "1.045" "1.039" "1.050" "1.081" "1.028" "0.608" "25300.1" "25811.6" "26191.5" "25953.4" "26443.4" "26295.3" "26574.1" "27342.9" "26020.3" "15393.8" "" "" "" "" "" "" "" "" "" "" "22435.6" "21381.0" "22853.3" "19409.7" "22050.2" "24155.1" "22459.4" "22600.8" "23864.2" "15393.8" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "470.449" "63" "31" "190" "31" "556" "60.3" "6.11" "761.35" "31" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "1.050" "1.062" "1.019" "1.077" "1.027" "1.096" "1.071" "1.066" "0.594" "18904.0" "19856.1" "20070.4" "19266.6" "20358.6" "19410.1" "20711.7" "20243.1" "20153.4" "11233.8" "" "" "" "" "" "" "" "" "" "" "16763.7" "16447.8" "17512.4" "14408.8" "16976.3" "17830.4" "17504.7" "16732.4" "18483.4" "11233.8" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "468.207" "66" "24" "437" "5" "444" "49.6" "4.89" "1437.05" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Potential therapeutics for SARS; Neutrophil degranulation; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "57" "28" "1.067" "1.133" "1.104" "1.103" "1.016" "1.144" "1.104" "1.138" "0.705" "33004.0" "35200.9" "37407.2" "36427.2" "36402.4" "33543.7" "37759.5" "36432.8" "37568.0" "23263.1" "" "" "" "" "" "" "" "" "" "" "29267.2" "29158.6" "32639.6" "27242.7" "30354.6" "30813.7" "31912.8" "30114.2" "34455.1" "23263.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "466.870" "47" "39" "136" "39" "968" "106.7" "5.53" "553.07" "39" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "Cytosolic tRNA aminoacylation" "IL-18 signaling pathway" "2" "0" "0.992" "1.085" "1.066" "1.052" "1.043" "1.359" "1.378" "1.350" "0.907" "13720.7" "13613.5" "14889.5" "14622.7" "14429.6" "14304.9" "18647.9" "18903.0" "18523.4" "12441.1" "" "" "" "" "" "" "" "" "" "" "12167.3" "11276.8" "12991.8" "10935.8" "12032.4" "13140.7" "15760.4" "15624.7" "16988.5" "12441.1" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "466.458" "20" "77" "113" "77" "4374" "481.6" "5.22" "412.38" "77" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "" "2" "0" "0.997" "0.956" "0.989" "0.954" "0.924" "1.011" "0.955" "0.969" "1.567" "6863.5" "6842.6" "6559.2" "6786.2" "6546.5" "6344.6" "6938.6" "6554.5" "6652.7" "10753.1" "" "" "" "" "" "" "" "" "" "" "6086.5" "5668.1" "5723.2" "5075.2" "5458.9" "5828.3" "5864.2" "5417.8" "6101.4" "10753.1" "53" "53" "53" "53" "53" "53" "53" "53" "53" "53" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "462.595" "66" "23" "414" "1" "445" "49.8" "4.89" "1361.46" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "MHC class II antigen presentation; COPI-mediated anterograde transport; PKR-mediated signaling; HCMV Early Events; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; Neutrophil degranulation; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "42" "5" "1.045" "1.049" "1.089" "1.059" "1.012" "1.138" "1.102" "1.099" "0.646" "4779.5" "4992.8" "5012.0" "5205.5" "5063.9" "4836.8" "5439.4" "5269.3" "5252.6" "3085.4" "" "" "" "" "" "" "" "" "" "" "4238.4" "4135.8" "4373.2" "3893.0" "4222.6" "4443.1" "4597.2" "4355.4" "4817.4" "3085.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "458.600" "44" "53" "189" "52" "1230" "136.3" "5.78" "686.80" "53" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "Endoderm differentiation" "4" "2" "1.036" "1.035" "1.057" "1.066" "1.029" "1.050" "1.093" "1.009" "0.534" "21633.2" "22413.4" "22381.5" "22875.0" "23070.0" "22253.3" "22719.3" "23638.9" "21818.3" "11552.2" "" "" "" "" "" "" "" "" "" "" "19183.9" "18566.1" "19529.0" "17107.5" "19237.3" "20442.1" "19201.4" "19539.3" "20010.4" "11552.2" "54" "54" "54" "54" "54" "54" "54" "54" "54" "54" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "458.417" "68" "38" "223" "38" "545" "60.5" "6.49" "824.07" "38" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "1.038" "1.036" "1.055" "1.080" "1.026" "1.052" "1.074" "1.026" "0.566" "22551.6" "23412.9" "23356.7" "23794.6" "24349.3" "23135.7" "23716.1" "24215.9" "23129.0" "12759.6" "" "" "" "" "" "" "" "" "" "" "19998.3" "19394.1" "20379.9" "17795.2" "20304.0" "21252.7" "20043.9" "20016.2" "21212.5" "12759.6" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "458.134" "44" "39" "142" "39" "1097" "123.6" "4.94" "554.50" "39" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "vRNP Assembly" "" "1" "0" "1.000" "1.011" "1.067" "1.048" "0.948" "1.182" "1.138" "1.077" "0.878" "13586.6" "13586.4" "13729.7" "14501.0" "14241.9" "12877.7" "16064.5" "15466.0" "14637.6" "11931.5" "" "" "" "" "" "" "" "" "" "" "12048.3" "11254.3" "11979.9" "10844.8" "11875.8" "11829.6" "13577.1" "12783.7" "13424.7" "11931.5" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "453.855" "46" "37" "188" "31" "894" "95.3" "8.76" "742.77" "37" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "" "2" "7" "0.988" "0.992" "0.982" "0.954" "0.914" "0.946" "0.976" "0.971" "0.645" "19512.7" "19270.8" "19365.0" "19164.4" "18610.4" "17828.9" "18454.6" "19042.3" "18955.5" "12579.8" "" "" "" "" "" "" "" "" "" "" "17303.5" "15963.0" "16896.9" "14332.4" "15518.6" "16377.8" "15597.1" "15739.8" "17384.8" "12579.8" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "450.238" "52" "46" "155" "45" "935" "101.5" "7.30" "611.57" "46" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "6" "1" "1.016" "1.033" "0.958" "0.996" "1.014" "0.959" "1.003" "0.969" "0.707" "19494.5" "19811.0" "20139.8" "18674.9" "19412.2" "19776.6" "18686.0" "19553.7" "18896.3" "13775.0" "" "" "" "" "" "" "" "" "" "" "17287.3" "16410.4" "17572.9" "13966.4" "16187.2" "18167.0" "15792.6" "16162.5" "17330.5" "13775.0" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "449.850" "29" "72" "102" "72" "3256" "358.5" "9.45" "388.44" "72" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "" "Primary focal segmental glomerulosclerosis (FSGS)" "1" "0" "0.987" "0.961" "0.944" "0.946" "0.879" "0.938" "0.917" "0.922" "0.555" "15828.2" "15617.9" "15218.2" "14938.2" "14978.6" "13912.9" "14847.3" "14517.5" "14599.2" "8789.1" "" "" "" "" "" "" "" "" "" "" "14036.1" "12937.1" "13278.6" "11171.8" "12490.1" "12780.5" "12548.4" "11999.8" "13389.4" "8789.1" "60" "60" "60" "60" "60" "60" "60" "60" "60" "60" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "448.601" "37" "72" "111" "71" "2136" "244.4" "6.06" "417.19" "72" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2q11.2 copy number variation syndrome" "3" "1" "1.017" "0.999" "1.045" "1.042" "1.015" "1.002" "1.002" "0.949" "1.112" "11610.5" "11811.6" "11604.5" "12131.2" "12096.9" "11785.7" "11627.9" "11633.6" "11022.4" "12909.6" "" "" "" "" "" "" "" "" "" "" "10295.9" "9784.1" "10125.5" "9072.5" "10087.1" "10826.5" "9827.5" "9616.0" "10109.1" "12909.6" "60" "60" "60" "60" "60" "60" "60" "60" "60" "60" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "446.358" "52" "59" "123" "59" "1224" "138.3" "7.66" "497.71" "59" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.027" "1.034" "0.994" "1.017" "1.008" "0.987" "0.971" "0.957" "1.116" "14562.1" "14958.4" "15056.5" "14475.8" "14813.7" "14682.5" "14378.4" "14139.3" "13936.9" "16250.3" "" "" "" "" "" "" "" "" "" "" "12913.3" "12390.8" "13137.5" "10826.0" "12352.6" "13487.6" "12152.0" "11687.1" "12782.0" "16250.3" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "445.059" "46" "47" "141" "47" "1249" "138.3" "6.32" "582.81" "47" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.019" "1.032" "1.046" "1.053" "1.058" "1.056" "1.055" "1.025" "0.580" "19221.2" "19588.3" "19840.1" "20111.6" "20240.4" "20338.2" "20289.5" "20282.6" "19707.9" "11146.2" "" "" "" "" "" "" "" "" "" "" "17045.0" "16225.9" "17311.4" "15040.8" "16877.7" "18682.9" "17147.8" "16765.0" "18074.8" "11146.2" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "442.274" "76" "32" "304" "4" "364" "39.4" "8.09" "1331.69" "32" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "25" "1.032" "1.070" "1.005" "1.027" "1.080" "1.049" "1.028" "1.014" "0.533" "27647.3" "28523.3" "29571.8" "27789.4" "28381.6" "29855.1" "29011.5" "28427.5" "28023.3" "14723.3" "" "" "" "" "" "" "" "" "" "" "24517.1" "23627.3" "25802.8" "20782.8" "23666.4" "27425.2" "24519.3" "23497.3" "25701.2" "14723.3" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-806880739347862445" "False" "High" "IsMasterProtein" "Q71U36" "Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1" "0.000" "False" "430.707" "64" "24" "463" "1" "451" "50.1" "5.06" "1876.17" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7846" "ENSG00000167552" "TUBA1A" "A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; The role of GTSE1 in G2/M progression after G2 checkpoint; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Recycling pathway of L1; COPI-mediated anterograde transport; Intraflagellar transport; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation" "42" "0" "1.117" "1.161" "1.099" "1.069" "1.045" "1.118" "1.074" "1.065" "0.746" "1772.9" "1979.6" "2059.1" "1947.6" "1896.0" "1853.1" "1981.7" "1903.4" "1888.0" "1323.2" "" "" "" "" "" "" "" "" "" "" "1572.2" "1639.8" "1796.7" "1456.5" "1581.0" "1702.3" "1674.8" "1573.3" "1731.6" "1323.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "428.885" "65" "34" "196" "33" "539" "57.9" "7.83" "735.18" "34" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "1.041" "1.046" "1.068" "1.062" "1.024" "0.986" "1.115" "1.032" "0.670" "24345.1" "25343.5" "25461.0" "26005.7" "25862.5" "24941.4" "23998.8" "27153.5" "25116.3" "16311.7" "" "" "" "" "" "" "" "" "" "" "21588.8" "20993.3" "22216.0" "19448.8" "21565.8" "22911.4" "20282.9" "22444.3" "23035.1" "16311.7" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "427.235" "47" "36" "134" "36" "953" "105.8" "5.39" "500.81" "36" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.015" "1.050" "1.085" "1.123" "1.066" "1.164" "1.119" "1.113" "0.696" "11863.8" "12044.4" "12452.5" "12868.8" "13318.7" "12644.2" "13808.8" "13278.6" "13205.2" "8262.4" "" "" "" "" "" "" "" "" "" "" "10520.6" "9977.0" "10865.4" "9624.1" "11106.0" "11615.1" "11670.6" "10975.7" "12111.0" "8262.4" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "426.862" "54" "51" "130" "40" "963" "109.6" "6.51" "473.82" "51" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "11" "11" "0.933" "0.955" "0.920" "0.891" "0.919" "0.997" "1.022" "1.053" "0.882" "14028.8" "13090.3" "13397.7" "12903.3" "12499.7" "12898.0" "13984.9" "14335.6" "14766.4" "12368.1" "" "" "" "" "" "" "" "" "" "" "12440.4" "10843.4" "11690.1" "9649.9" "10423.1" "11848.3" "11819.5" "11849.4" "13542.8" "12368.1" "51" "51" "51" "51" "51" "51" "51" "51" "51" "51" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6496925005546959600" "False" "High" "IsMasterProtein" "Q13509" "Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2" "0.000" "False" "418.621" "60" "23" "393" "10" "450" "50.4" "4.93" "1257.85" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10381" "ENSG00000258947" "TUBB3" "A8K854; hsa:10381; Q13509; Q9BTZ0; Q9BW10" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Hedgehog 'off' state; Post-chaperonin tubulin folding pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Exercise-induced circadian regulation; Alzheimer's disease; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "38" "3" "1.064" "1.077" "1.085" "1.093" "1.077" "1.089" "1.111" "1.062" "0.556" "10317.7" "10973.2" "11115.4" "11192.4" "11277.3" "11116.2" "11231.8" "11462.5" "10955.4" "5733.0" "" "" "" "" "" "" "" "" "" "" "9149.5" "9089.6" "9698.7" "8370.4" "9403.8" "10211.5" "9492.6" "9474.5" "10047.6" "5733.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "417.642" "50" "33" "128" "26" "784" "85.5" "7.55" "517.14" "33" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Glycolysis" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "7" "1.008" "1.008" "1.039" "1.049" "1.023" "1.020" "1.055" "0.943" "0.580" "13174.7" "13283.6" "13282.7" "13691.6" "13825.4" "13482.3" "13441.8" "13904.3" "12430.3" "7636.9" "" "" "" "" "" "" "" "" "" "" "11683.1" "11003.5" "11589.8" "10239.5" "11528.5" "12385.0" "11360.4" "11492.9" "11400.3" "7636.9" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "417.373" "64" "25" "291" "7" "448" "49.9" "5.06" "1206.70" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; PKR-mediated signaling; Recycling pathway of L1; MHC class II antigen presentation; RHO GTPases activate IQGAPs; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "160" "24" "1.030" "1.112" "0.997" "1.075" "1.055" "1.095" "1.105" "1.048" "0.707" "24694.2" "25425.8" "27462.1" "24622.0" "26540.4" "26058.9" "27041.8" "27298.3" "25889.7" "17456.1" "" "" "" "" "" "" "" "" "" "" "21898.3" "21061.5" "23962.0" "18414.0" "22131.1" "23938.0" "22854.6" "22563.9" "23744.4" "17456.1" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "412.080" "63" "22" "370" "1" "445" "49.9" "4.89" "1169.60" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "4" "1.031" "1.093" "1.021" "1.093" "1.107" "1.147" "1.200" "1.175" "0.598" "1939.5" "1998.7" "2120.5" "1979.7" "2120.4" "2146.7" "2224.8" "2327.4" "2278.4" "1159.5" "" "" "" "" "" "" "" "" "" "" "1719.9" "1655.6" "1850.2" "1480.5" "1768.1" "1972.0" "1880.4" "1923.8" "2089.6" "1159.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "407.633" "56" "46" "102" "45" "972" "109.4" "5.00" "401.14" "46" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; Ciliary landscape" "4" "0" "1.040" "1.051" "1.087" "1.099" "1.076" "1.065" "1.084" "1.000" "0.431" "11350.1" "11808.1" "11931.8" "12341.5" "12478.3" "12213.1" "12090.0" "12300.9" "11354.8" "4889.6" "" "" "" "" "" "" "" "" "" "" "10065.1" "9781.3" "10411.1" "9229.8" "10405.2" "11219.1" "10218.0" "10167.6" "10413.9" "4889.6" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "406.820" "22" "60" "81" "59" "3051" "330.3" "5.08" "341.99" "60" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "0.970" "0.940" "0.957" "0.945" "0.978" "0.899" "0.943" "0.961" "0.497" "10376.9" "10066.2" "9758.0" "9928.3" "9810.4" "10152.1" "9329.4" "9789.4" "9970.7" "5161.6" "" "" "" "" "" "" "" "" "" "" "9202.0" "8338.3" "8514.3" "7425.0" "8180.5" "9325.9" "7884.8" "8091.6" "9144.5" "5161.6" "50" "50" "50" "50" "50" "50" "50" "50" "50" "50" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250102899765152791" "False" "High" "IsMasterProtein" "Q9BVA1" "Tubulin beta-2B chain OS=Homo sapiens OX=9606 GN=TUBB2B PE=1 SV=1" "0.000" "False" "405.610" "63" "22" "367" "1" "445" "49.9" "4.89" "1155.04" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "347733" "ENSG00000137285" "TUBB2B" "A8K068; hsa:347733; Q9BVA1" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; COPI-mediated anterograde transport; MHC class II antigen presentation; Recycling pathway of L1; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Assembly and cell surface presentation of NMDA receptors; PKR-mediated signaling; Intraflagellar transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "0" "0.739" "1.302" "0.691" "0.833" "1.083" "0.913" "1.132" "0.961" "0.590" "298.1" "220.4" "388.2" "206.0" "248.2" "322.8" "272.3" "337.5" "286.4" "175.8" "" "" "" "" "" "" "" "" "" "" "264.4" "182.6" "338.7" "154.1" "207.0" "296.6" "230.1" "278.9" "262.7" "175.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "404.307" "38" "55" "151" "55" "1488" "152.0" "9.04" "503.01" "55" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "0.920" "0.913" "0.856" "0.820" "0.836" "0.802" "0.838" "0.854" "0.608" "20301.3" "18684.0" "18532.6" "17369.8" "16651.5" "16967.1" "16282.9" "17018.5" "17327.8" "12352.3" "" "" "" "" "" "" "" "" "" "" "18002.8" "15476.9" "16170.6" "12990.3" "13885.1" "15586.2" "13761.6" "14067.0" "15892.0" "12352.3" "52" "52" "52" "52" "52" "52" "52" "52" "52" "52" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "403.198" "54" "40" "199" "39" "803" "92.4" "4.84" "744.53" "40" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "1.018" "1.036" "1.028" "1.050" "1.059" "1.114" "1.153" "1.108" "0.506" "20795.7" "21161.9" "21535.7" "21371.9" "21830.8" "22018.5" "23163.3" "23986.4" "23040.3" "10520.7" "" "" "" "" "" "" "" "" "" "" "18441.2" "17529.5" "18790.9" "15983.3" "18203.9" "20226.5" "19576.7" "19826.5" "21131.1" "10520.7" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "403.092" "54" "30" "166" "30" "623" "67.8" "7.66" "675.98" "30" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "7" "0" "0.999" "1.033" "0.987" "1.003" "1.044" "0.985" "1.006" "1.006" "0.498" "17312.0" "17300.5" "17887.8" "17090.2" "17360.6" "18073.1" "17050.1" "17421.9" "17418.3" "8623.6" "" "" "" "" "" "" "" "" "" "" "15352.0" "14330.9" "15608.0" "12781.2" "14476.4" "16602.1" "14410.0" "14400.4" "15975.0" "8623.6" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "402.747" "64" "24" "352" "3" "449" "49.9" "5.10" "1363.77" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "HCMV Early Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Sealing of the nuclear envelope (NE) by ESCRT-III; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "37" "5" "1.014" "1.009" "1.048" "1.017" "1.022" "1.080" "1.026" "0.970" "0.722" "13163.8" "13343.6" "13278.0" "13801.8" "13388.2" "13449.5" "14213.7" "13511.3" "12774.4" "9499.4" "" "" "" "" "" "" "" "" "" "" "11673.4" "11053.2" "11585.7" "10321.9" "11164.0" "12354.9" "12012.8" "11168.1" "11715.8" "9499.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "402.498" "54" "51" "169" "43" "866" "101.2" "7.42" "622.45" "51" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "11" "0.969" "0.967" "0.974" "0.935" "0.922" "0.918" "0.978" "0.943" "0.541" "19680.5" "19067.3" "19039.2" "19160.4" "18403.4" "18138.3" "18073.1" "19254.9" "18555.4" "10656.3" "" "" "" "" "" "" "" "" "" "" "17452.3" "15794.4" "16612.6" "14329.4" "15345.9" "16662.1" "15274.7" "15915.6" "17017.9" "10656.3" "51" "51" "51" "51" "51" "51" "51" "51" "51" "51" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "401.527" "53" "25" "116" "23" "514" "55.8" "6.90" "504.57" "25" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Potential therapeutics for SARS; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "Rett syndrome" "5" "2" "0.989" "1.070" "1.007" "1.077" "1.071" "1.086" "1.138" "1.149" "0.583" "12570.9" "12436.1" "13451.0" "12655.8" "13544.4" "13460.8" "13650.5" "14300.7" "14442.9" "7328.3" "" "" "" "" "" "" "" "" "" "" "11147.6" "10301.4" "11736.6" "9464.9" "11294.2" "12365.2" "11536.8" "11820.5" "13246.1" "7328.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "400.355" "64" "38" "216" "38" "543" "62.6" "6.80" "715.34" "38" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "VEGFA-VEGFR2 signaling" "3" "0" "0.936" "0.964" "0.907" "0.916" "0.980" "0.975" "0.964" "0.987" "0.753" "29273.9" "27407.3" "28222.9" "26554.5" "26800.8" "28685.8" "28556.4" "28211.0" "28893.3" "22034.7" "" "" "" "" "" "" "" "" "" "" "25959.5" "22702.9" "24625.8" "19859.3" "22348.3" "26351.1" "24134.7" "23318.3" "26499.1" "22034.7" "51" "51" "51" "51" "51" "51" "51" "51" "51" "51" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "400.251" "77" "35" "206" "24" "445" "50.6" "6.47" "748.67" "35" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation" "" "2" "10" "1.058" "1.086" "1.056" "1.085" "1.084" "1.028" "1.074" "1.006" "0.574" "26843.2" "28413.0" "29146.5" "28348.4" "29137.1" "29090.3" "27599.0" "28842.4" "26995.5" "15420.9" "" "" "" "" "" "" "" "" "" "" "23804.0" "23536.0" "25431.7" "21200.9" "24296.4" "26722.7" "23325.6" "23840.3" "24758.6" "15420.9" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "398.937" "57" "34" "159" "33" "704" "80.1" "8.21" "657.27" "34" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "Respiratory electron transport" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "4" "0" "1.062" "1.139" "1.116" "1.170" "1.102" "1.200" "1.220" "1.219" "0.529" "12762.2" "13551.3" "14532.6" "14239.4" "14932.4" "14068.1" "15317.1" "15566.2" "15556.7" "6752.5" "" "" "" "" "" "" "" "" "" "" "11317.3" "11225.2" "12680.4" "10649.2" "12451.6" "12923.1" "12945.4" "12866.6" "14267.7" "6752.5" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "396.192" "44" "44" "100" "43" "1217" "135.5" "5.26" "389.87" "44" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.030" "1.006" "1.035" "1.047" "0.999" "0.986" "0.986" "0.926" "0.798" "8995.9" "9268.4" "9047.7" "9308.7" "9420.2" "8983.8" "8867.0" "8869.2" "8327.5" "7181.5" "" "" "" "" "" "" "" "" "" "" "7977.4" "7677.4" "7894.6" "6961.7" "7855.2" "8252.6" "7494.0" "7331.0" "7637.5" "7181.5" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2749950876556130584" "False" "High" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "0.000" "False" "394.258" "62" "37" "218" "19" "641" "70.0" "5.66" "776.25" "37" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection" "12" "14" "0.972" "1.004" "0.954" "0.947" "1.010" "1.023" "1.040" "1.060" "0.622" "14260.9" "13866.5" "14318.5" "13604.5" "13504.6" "14404.2" "14595.1" "14835.7" "15113.9" "8877.4" "" "" "" "" "" "" "" "" "" "" "12646.3" "11486.3" "12493.6" "10174.4" "11261.0" "13231.8" "12335.2" "12262.8" "13861.5" "8877.4" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "393.925" "57" "35" "154" "30" "711" "73.1" "7.30" "595.15" "35" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "Pre-implantation embryo" "3" "4" "0.963" "0.916" "0.930" "0.888" "0.893" "0.886" "0.933" "0.931" "0.487" "18001.2" "17340.4" "16489.8" "16745.2" "15985.6" "16070.2" "15954.2" "16798.0" "16759.5" "8767.1" "" "" "" "" "" "" "" "" "" "" "15963.1" "14363.9" "14388.2" "12523.2" "13329.9" "14762.3" "13483.8" "13884.7" "15370.7" "8767.1" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "392.592" "41" "45" "131" "45" "1140" "126.9" "5.26" "496.17" "45" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "14" "0" "1.047" "1.049" "1.084" "1.102" "1.085" "1.123" "1.134" "1.009" "0.538" "12800.0" "13407.0" "13425.6" "13878.1" "14111.2" "13881.7" "14376.6" "14508.8" "12910.7" "6883.4" "" "" "" "" "" "" "" "" "" "" "11350.8" "11105.7" "11714.5" "10379.0" "11766.8" "12751.9" "12150.5" "11992.5" "11840.9" "6883.4" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "391.468" "50" "37" "111" "37" "904" "101.8" "5.52" "465.08" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "11" "0" "0.954" "0.985" "1.043" "1.024" "0.972" "1.311" "1.270" "1.192" "1.369" "12271.0" "11710.9" "12081.4" "12794.7" "12565.3" "11924.3" "16088.9" "15580.3" "14631.4" "16805.2" "" "" "" "" "" "" "" "" "" "" "10881.7" "9700.7" "10541.6" "9568.8" "10477.7" "10953.8" "13597.7" "12878.2" "13419.0" "16805.2" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "390.354" "30" "60" "112" "35" "1976" "228.9" "5.54" "417.59" "60" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "EPHA-mediated growth cone collapse; RHO GTPases activate PAKs; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs" "Regulation of actin cytoskeleton" "7" "2" "0.986" "0.916" "1.044" "1.008" "1.051" "1.099" "1.008" "1.065" "1.502" "4529.4" "4465.8" "4148.0" "4729.1" "4564.3" "4758.9" "4979.7" "4564.1" "4823.1" "6801.8" "" "" "" "" "" "" "" "" "" "" "4016.5" "3699.3" "3619.3" "3536.7" "3806.0" "4371.6" "4208.7" "3772.5" "4423.5" "6801.8" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "387.661" "49" "36" "114" "36" "788" "85.2" "4.30" "428.30" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "0.952" "0.963" "0.888" "0.858" "0.923" "0.847" "0.895" "0.919" "1.023" "15427.3" "14681.3" "14860.9" "13705.2" "13236.0" "14246.8" "13072.9" "13803.2" "14175.0" "15784.0" "" "" "" "" "" "" "" "" "" "" "13680.6" "12161.3" "12966.9" "10249.7" "11037.1" "13087.3" "11048.7" "11409.3" "13000.4" "15784.0" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "377.608" "57" "45" "201" "32" "577" "67.8" "6.40" "713.82" "45" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "10" "3" "0.984" "0.995" "0.867" "0.857" "0.833" "0.799" "0.876" "0.909" "0.698" "15319.5" "15067.8" "15250.0" "13286.5" "13122.7" "12767.1" "12236.9" "13419.8" "13924.4" "10688.8" "" "" "" "" "" "" "" "" "" "" "13585.0" "12481.4" "13306.4" "9936.5" "10942.6" "11728.0" "10342.2" "11092.4" "12770.6" "10688.8" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8572654492564419660" "False" "High" "IsMasterProtein" "P0DPH8" "Tubulin alpha-3D chain OS=Homo sapiens OX=9606 GN=TUBA3D PE=1 SV=1" "0.000" "False" "375.983" "54" "20" "303" "1" "450" "49.9" "5.10" "1272.56" "20" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "113457" "ENSG00000075886" "TUBA3D" "A6NJQ0; hsa:113457; P0DPH8; Q13748; Q5W099; Q6PEY3; Q96F18" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; 2q21.1 copy number variation syndrome" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "374.976" "47" "64" "89" "63" "1411" "162.4" "5.68" "375.67" "64" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "Toll Like Receptor 9 (TLR9) Cascade" "VEGFA-VEGFR2 signaling" "2" "1" "1.002" "0.934" "0.975" "0.935" "0.945" "0.910" "0.947" "0.973" "0.515" "12270.2" "12296.3" "11464.7" "11968.8" "11468.9" "11597.0" "11168.7" "11616.6" "11940.2" "6313.4" "" "" "" "" "" "" "" "" "" "" "10881.0" "10185.6" "10003.5" "8951.1" "9563.5" "10653.1" "9439.3" "9602.0" "10950.8" "6313.4" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "373.539" "22" "18" "521" "18" "653" "68.1" "7.24" "2466.92" "18" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "0.858" "0.753" "0.861" "0.859" "0.934" "0.891" "0.933" "0.922" "0.589" "45831.1" "39345.9" "34524.5" "39472.9" "39355.6" "42786.9" "40836.5" "42744.0" "42250.1" "26979.4" "" "" "" "" "" "" "" "" "" "" "40642.1" "32592.2" "30124.3" "29520.5" "32817.2" "39304.5" "34513.4" "35330.9" "38749.2" "26979.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "372.361" "65" "48" "212" "34" "586" "69.4" "6.27" "745.60" "48" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Sensory processing of sound by outer hair cells of the cochlea; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Netrin-1 signaling" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "11" "15" "0.992" "1.042" "0.914" "0.936" "0.948" "0.917" "0.931" "0.978" "0.737" "23295.7" "23099.6" "24280.0" "21287.3" "21811.7" "22088.4" "21356.7" "21697.8" "22782.8" "17173.5" "" "" "" "" "" "" "" "" "" "" "20658.2" "19134.6" "21185.5" "15920.1" "18188.0" "20290.7" "18049.8" "17934.7" "20894.9" "17173.5" "50" "50" "50" "50" "50" "50" "50" "50" "50" "50" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1047543099056468626" "False" "High" "IsMasterProtein" "P09104" "Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3" "0.000" "False" "372.270" "62" "18" "151" "15" "434" "47.2" "5.03" "693.76" "18" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "2026" "ENSG00000111674" "ENO2" "B7Z2X9; hsa:2026; P09104; Q96J33" "Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "1.019" "1.012" "1.050" "1.035" "1.013" "1.036" "1.038" "1.022" "0.524" "8898.1" "9069.8" "9008.3" "9340.0" "9212.0" "9014.7" "9220.2" "9232.6" "9093.1" "4660.6" "" "" "" "" "" "" "" "" "" "" "7890.7" "7512.9" "7860.2" "6985.1" "7681.6" "8281.0" "7792.5" "7631.4" "8339.6" "4660.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "370.645" "63" "29" "306" "29" "462" "50.1" "9.01" "1072.77" "29" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Peptide chain elongation; Neutrophil degranulation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; SARS-CoV-1 modulates host translation machinery" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "20" "0" "0.970" "1.068" "0.994" "1.029" "1.051" "1.036" "1.091" "1.135" "0.876" "35610.3" "34551.1" "38047.9" "35383.4" "36660.3" "37429.4" "36904.9" "38835.9" "40417.3" "31204.7" "" "" "" "" "" "" "" "" "" "" "31578.5" "28620.4" "33198.7" "26462.1" "30569.7" "34383.1" "31190.5" "32100.6" "37068.2" "31204.7" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "368.167" "55" "40" "89" "36" "858" "96.8" "5.39" "365.42" "40" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "" "2" "2" "1.008" "0.985" "0.921" "0.942" "0.955" "0.978" "0.798" "0.973" "3.694" "9910.9" "9994.7" "9760.8" "9124.1" "9333.1" "9468.8" "9689.5" "7913.3" "9638.7" "36607.4" "" "" "" "" "" "" "" "" "" "" "8788.8" "8279.1" "8516.8" "6823.7" "7782.5" "8698.1" "8189.1" "6540.9" "8840.0" "36607.4" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "367.320" "34" "48" "76" "48" "1972" "213.4" "4.70" "331.54" "48" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); SUMOylation of transcription factors" "ATM signaling pathway; ATM signaling in development and disease" "7" "0" "0.992" "0.981" "0.987" "0.966" "0.986" "0.980" "0.905" "0.954" "1.979" "8068.1" "8002.7" "7917.2" "7961.9" "7796.1" "7957.3" "7905.9" "7298.0" "7694.2" "15969.0" "" "" "" "" "" "" "" "" "" "" "7154.6" "6629.0" "6908.1" "5954.4" "6500.9" "7309.7" "6681.7" "6032.3" "7056.7" "15969.0" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "363.666" "44" "34" "106" "34" "953" "107.1" "6.05" "405.66" "34" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Neutrophil degranulation" "" "3" "0" "1.016" "0.982" "1.025" "1.029" "0.976" "0.953" "0.964" "0.934" "1.182" "10457.7" "10629.4" "10269.5" "10714.3" "10758.4" "10210.7" "9964.7" "10086.1" "9766.9" "12357.3" "" "" "" "" "" "" "" "" "" "" "9273.6" "8804.9" "8960.6" "8012.9" "8971.0" "9379.6" "8421.7" "8336.9" "8957.6" "12357.3" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "360.833" "46" "31" "85" "30" "808" "89.2" "4.65" "366.39" "31" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "5" "2" "0.936" "0.961" "0.927" "0.938" "0.961" "0.835" "0.887" "0.873" "0.512" "12146.9" "11364.4" "11674.0" "11265.5" "11399.8" "11671.3" "10143.1" "10775.7" "10607.7" "6220.0" "" "" "" "" "" "" "" "" "" "" "10771.6" "9413.7" "10186.1" "8425.1" "9505.9" "10721.4" "8572.5" "8906.9" "9728.7" "6220.0" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "359.936" "64" "38" "88" "37" "645" "72.9" "5.07" "327.45" "38" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "1" "0.986" "1.006" "0.976" "1.013" "1.032" "1.041" "1.030" "1.031" "1.501" "8392.3" "8276.9" "8444.6" "8194.0" "8499.4" "8657.4" "8735.6" "8645.6" "8655.3" "12593.3" "" "" "" "" "" "" "" "" "" "" "7442.1" "6856.2" "7368.3" "6128.0" "7087.4" "7952.8" "7383.0" "7146.2" "7938.1" "12593.3" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "358.153" "47" "36" "126" "36" "792" "90.0" "7.15" "472.59" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Interconversion of nucleotide di- and triphosphates" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "1.036" "1.044" "1.059" "1.105" "1.080" "1.157" "1.226" "1.137" "0.597" "13332.9" "13809.7" "13917.0" "14123.6" "14733.3" "14395.3" "15426.9" "16348.3" "15156.9" "7959.4" "" "" "" "" "" "" "" "" "" "" "11823.3" "11439.2" "12143.2" "10562.6" "12285.6" "13223.7" "13038.2" "13513.0" "13901.0" "7959.4" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "357.321" "54" "31" "179" "23" "644" "67.5" "7.61" "687.34" "31" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "4" "0.943" "0.949" "0.905" "0.901" "0.933" "0.886" "0.965" "0.954" "0.495" "23255.6" "21928.1" "22070.6" "21047.4" "20964.2" "21695.4" "20593.6" "22438.0" "22175.0" "11520.3" "" "" "" "" "" "" "" "" "" "" "20622.6" "18164.1" "19257.6" "15740.7" "17481.3" "19929.7" "17404.8" "18546.6" "20337.5" "11520.3" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "354.232" "26" "41" "94" "41" "2035" "208.6" "7.46" "370.19" "41" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "Mitochondrial gene expression; Pleural mesothelioma" "6" "0" "0.982" "0.993" "0.985" "1.008" "0.980" "0.999" "1.012" "0.975" "0.781" "9276.2" "9107.8" "9210.3" "9140.1" "9346.8" "9093.6" "9270.6" "9383.2" "9042.1" "7242.9" "" "" "" "" "" "" "" "" "" "" "8225.9" "7544.5" "8036.5" "6835.6" "7793.9" "8353.5" "7835.1" "7755.9" "8292.9" "7242.9" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "350.029" "56" "39" "117" "39" "734" "82.2" "8.37" "453.35" "39" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "10" "0" "1.033" "1.037" "1.048" "1.073" "1.016" "1.154" "1.130" "1.096" "0.831" "9427.2" "9736.0" "9776.9" "9880.2" "10111.1" "9576.9" "10877.2" "10656.2" "10333.2" "7836.6" "" "" "" "" "" "" "" "" "" "" "8359.8" "8064.8" "8530.8" "7389.1" "8431.3" "8797.4" "9193.0" "8808.1" "9477.0" "7836.6" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "345.539" "63" "22" "91" "22" "456" "50.2" "6.42" "410.43" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "UCH proteinases; Ub-specific processing proteases; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; HATs acetylate histones; DNA Damage Recognition in GG-NER" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "9" "0" "0.975" "0.963" "0.994" "1.032" "0.997" "0.984" "0.989" "0.945" "0.787" "11096.2" "10816.9" "10688.3" "11029.7" "11450.8" "11066.5" "10919.6" "10979.1" "10480.6" "8735.7" "" "" "" "" "" "" "" "" "" "" "9839.9" "8960.2" "9326.1" "8248.8" "9548.4" "10165.8" "9228.8" "9075.0" "9612.1" "8735.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5279545747934132258" "False" "High" "IsMasterProtein" "P04350" "Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2" "0.000" "False" "345.501" "53" "18" "349" "1" "444" "49.6" "4.88" "1078.19" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10382" "ENSG00000104833" "TUBB4A" "B3KQP4; hsa:10382; P04350; Q969E5" "RHO GTPases Activate Formins; HCMV Early Events; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "41" "0" "0.996" "0.895" "1.076" "0.969" "1.005" "1.060" "1.061" "1.012" "0.835" "185.6" "184.8" "166.1" "199.7" "179.7" "186.6" "196.6" "196.8" "187.8" "154.9" "" "" "" "" "" "" "" "" "" "" "164.5" "153.1" "145.0" "149.3" "149.9" "171.4" "166.2" "162.7" "172.2" "154.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "345.190" "21" "54" "107" "52" "2896" "316.7" "9.13" "378.26" "54" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "" "VEGFA-VEGFR2 signaling" "1" "1" "0.986" "0.964" "0.975" "0.955" "0.904" "0.914" "0.952" "0.950" "0.437" "12846.4" "12672.8" "12379.8" "12522.6" "12269.1" "11611.3" "11744.9" "12225.3" "12205.3" "5615.2" "" "" "" "" "" "" "" "" "" "" "11391.9" "10497.5" "10802.0" "9365.3" "10230.8" "10666.3" "9926.3" "10105.1" "11193.9" "5615.2" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "341.834" "45" "33" "110" "32" "795" "90.9" "7.46" "418.45" "33" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.044" "1.019" "1.088" "1.132" "1.063" "1.092" "1.113" "1.019" "0.479" "11153.4" "11646.8" "11370.6" "12134.9" "12622.3" "11861.2" "12175.1" "12417.0" "11359.8" "5338.2" "" "" "" "" "" "" "" "" "" "" "9890.6" "9647.7" "9921.4" "9075.3" "10525.3" "10895.8" "10289.9" "10263.5" "10418.5" "5338.2" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "340.635" "49" "37" "111" "37" "768" "88.9" "8.48" "430.86" "37" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "16" "0" "1.026" "1.011" "0.978" "1.026" "0.985" "0.966" "1.008" "0.955" "0.492" "13330.9" "13676.5" "13471.9" "13041.1" "13671.8" "13126.1" "12873.2" "13431.1" "12727.1" "6564.3" "" "" "" "" "" "" "" "" "" "" "11821.6" "11328.9" "11754.9" "9753.0" "11400.4" "12057.8" "10879.9" "11101.8" "11672.5" "6564.3" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "340.429" "46" "41" "73" "41" "1129" "124.3" "6.61" "312.20" "41" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Pathophysiological roles of DUX4 in FSHD1" "3" "0" "1.018" "1.034" "0.995" "1.019" "0.995" "1.000" "1.021" "0.983" "0.737" "8098.6" "8245.6" "8376.2" "8061.4" "8249.9" "8060.9" "8100.6" "8264.9" "7961.5" "5970.8" "" "" "" "" "" "" "" "" "" "" "7181.7" "6830.3" "7308.6" "6028.8" "6879.3" "7404.8" "6846.3" "6831.5" "7301.8" "5970.8" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "336.087" "48" "32" "116" "32" "739" "83.1" "7.03" "453.33" "32" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "HDAC6 interactions in the central nervous system" "3" "0" "1.026" "1.054" "1.082" "1.073" "1.033" "1.045" "1.069" "1.033" "0.469" "11551.4" "11852.2" "12173.1" "12498.1" "12399.9" "11926.9" "12074.9" "12346.2" "11937.3" "5418.8" "" "" "" "" "" "" "" "" "" "" "10243.6" "9817.7" "10621.6" "9346.9" "10339.9" "10956.2" "10205.3" "10205.0" "10948.1" "5418.8" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "335.026" "76" "22" "295" "19" "255" "29.2" "4.74" "994.37" "22" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Regulation of HSF1-mediated heat shock response; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; HSF1 activation; NADE modulates death signalling; Activation of BAD and translocation to mitochondria" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "26" "4" "1.005" "1.017" "0.993" "0.999" "1.027" "0.999" "1.019" "1.033" "0.482" "33148.6" "33310.6" "33716.9" "32905.4" "33105.8" "34049.7" "33113.8" "33768.8" "34256.3" "15979.5" "" "" "" "" "" "" "" "" "" "" "29395.5" "27592.9" "29419.6" "24608.9" "27605.7" "31278.5" "27986.5" "27912.3" "31417.7" "15979.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "334.103" "48" "35" "73" "35" "863" "96.5" "6.74" "300.45" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "12" "0" "0.951" "0.990" "1.018" "1.026" "0.995" "1.330" "1.293" "1.297" "1.381" "6499.5" "6181.9" "6437.0" "6614.0" "6669.1" "6469.7" "8644.7" "8406.6" "8429.8" "8978.9" "" "" "" "" "" "" "" "" "" "" "5763.6" "5120.8" "5616.6" "4946.4" "5561.1" "5943.1" "7306.2" "6948.6" "7731.3" "8978.9" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "333.986" "52" "23" "158" "23" "478" "52.9" "5.82" "629.18" "23" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "0.974" "0.961" "0.967" "0.971" "0.981" "0.879" "0.901" "0.920" "0.540" "16725.1" "16295.7" "16078.5" "16172.3" "16235.7" "16411.6" "14703.6" "15067.3" "15387.0" "9038.3" "" "" "" "" "" "" "" "" "" "" "14831.5" "13498.6" "14029.3" "12094.7" "13538.4" "15075.9" "12426.9" "12454.2" "14112.0" "9038.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1675447815179810956" "False" "High" "IsMasterProtein" "Cont_P00883" "Fructose-bisphosphate aldolase A OS=Oryctolagus cuniculus OX=9986 GN=ALDOA PE=1 SV=2" "0.000" "True" "333.611" "62" "29" "222" "1" "364" "39.3" "8.09" "855.06" "29" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytoskeleton" "other molecular function" "Pf00274" "100009055" "ENSOCUG00000006329" "ALDOA" "ocu:100009055; P00883; Q28671" "" "" "0" "0" "1.021" "0.996" "0.658" "1.113" "1.070" "1.100" "1.055" "0.874" "0.580" "192.6" "196.7" "191.9" "126.7" "214.3" "206.0" "211.8" "203.2" "168.3" "111.8" "" "" "" "" "" "" "" "" "" "" "170.8" "162.9" "167.4" "94.8" "178.7" "189.3" "179.0" "167.9" "154.4" "111.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "331.750" "58" "24" "114" "24" "463" "51.1" "5.64" "453.93" "24" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "HATs acetylate histones; Telomere Extension By Telomerase" "" "2" "0" "1.038" "0.983" "1.063" "1.078" "1.074" "1.078" "1.052" "0.978" "0.815" "12177.6" "12634.6" "11971.6" "12946.2" "13125.6" "13078.5" "13129.2" "12806.0" "11905.5" "9930.7" "" "" "" "" "" "" "" "" "" "" "10798.9" "10465.9" "10445.8" "9682.0" "10945.0" "12014.1" "11096.2" "10585.1" "10919.0" "9930.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "325.453" "55" "31" "104" "30" "649" "73.4" "7.88" "399.55" "31" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "" "Progeria-associated lipodystrophy" "1" "1" "0.989" "1.013" "0.963" "0.978" "1.002" "0.959" "1.012" "0.989" "0.541" "13941.0" "13787.7" "14125.5" "13424.9" "13637.9" "13969.4" "13367.5" "14106.6" "13788.2" "7546.3" "" "" "" "" "" "" "" "" "" "" "12362.6" "11421.0" "12325.2" "10040.0" "11372.2" "12832.4" "11297.6" "11660.1" "12645.7" "7546.3" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "325.258" "30" "43" "75" "43" "1657" "189.1" "6.48" "305.54" "43" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "25" "0" "1.007" "0.975" "1.012" "0.975" "0.916" "1.088" "0.812" "1.080" "5.321" "4784.4" "4819.4" "4666.3" "4841.0" "4667.2" "4384.2" "5205.0" "3887.1" "5166.2" "25457.4" "" "" "" "" "" "" "" "" "" "" "4242.7" "3992.1" "4071.5" "3620.4" "3891.8" "4027.4" "4399.1" "3212.9" "4738.1" "25457.4" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "323.153" "45" "39" "78" "39" "919" "103.2" "5.72" "316.77" "39" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.953" "0.983" "1.034" "0.990" "0.911" "1.209" "1.148" "1.050" "1.053" "9861.9" "9396.8" "9698.5" "10199.9" "9762.0" "8981.1" "11927.4" "11317.9" "10354.2" "10381.8" "" "" "" "" "" "" "" "" "" "" "8745.3" "7783.8" "8462.4" "7628.2" "8140.2" "8250.2" "10080.6" "9355.0" "9496.2" "10381.8" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "321.734" "45" "29" "86" "26" "780" "85.1" "7.99" "347.59" "29" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Glycolysis" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "1" "1.029" "1.040" "1.076" "1.077" "1.041" "1.040" "1.063" "0.985" "0.551" "7744.4" "7970.2" "8050.5" "8333.2" "8342.4" "8061.5" "8052.8" "8233.7" "7625.7" "4268.2" "" "" "" "" "" "" "" "" "" "" "6867.6" "6602.1" "7024.4" "6232.1" "6956.5" "7405.4" "6805.9" "6805.7" "6993.8" "4268.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "316.550" "49" "31" "81" "31" "826" "92.2" "7.90" "311.66" "31" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "" "4" "0" "1.052" "1.031" "1.111" "1.094" "1.025" "1.118" "1.087" "1.015" "0.685" "7272.6" "7651.3" "7495.5" "8079.0" "7959.4" "7451.7" "8128.7" "7902.0" "7380.4" "4984.6" "" "" "" "" "" "" "" "" "" "" "6449.2" "6338.0" "6540.2" "6042.0" "6637.1" "6845.2" "6870.1" "6531.6" "6768.8" "4984.6" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994958122545782914" "False" "High" "IsMasterProtein" "Cont_Q9XSJ4" "Alpha-enolase OS=Bos taurus OX=9913 GN=ENO1 PE=1 SV=4" "0.000" "True" "315.409" "57" "21" "320" "3" "434" "47.3" "6.80" "1288.74" "21" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "281141" "" "ENO1" "bta:281141; Q3SYW4; Q9XSJ4" "" "" "0" "0" "1.364" "1.199" "1.417" "1.337" "1.095" "1.101" "1.280" "1.306" "0.680" "100.1" "136.5" "120.0" "141.8" "133.8" "109.6" "110.1" "128.1" "130.7" "68.1" "" "" "" "" "" "" "" "" "" "" "88.7" "113.1" "104.7" "106.1" "111.6" "100.6" "93.1" "105.9" "119.9" "68.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "313.439" "31" "23" "86" "23" "1087" "114.5" "7.11" "402.53" "23" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.960" "0.960" "0.935" "0.948" "0.935" "0.936" "0.990" "0.997" "0.501" "13568.3" "13027.4" "13028.3" "12686.8" "12862.9" "12689.8" "12699.6" "13430.6" "13529.8" "6800.4" "" "" "" "" "" "" "" "" "" "" "12032.1" "10791.3" "11367.8" "9488.0" "10725.9" "11657.0" "10733.2" "11101.4" "12408.7" "6800.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "311.859" "37" "43" "81" "43" "1220" "138.7" "5.49" "336.66" "43" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; Ciliary landscape" "3" "0" "0.961" "0.965" "0.987" "0.946" "0.981" "1.046" "1.000" "0.999" "0.929" "12237.2" "11758.4" "11806.0" "12075.9" "11574.6" "12007.0" "12801.7" "12236.9" "12223.0" "11372.7" "" "" "" "" "" "" "" "" "" "" "10851.7" "9740.0" "10301.3" "9031.2" "9651.6" "11029.8" "10819.5" "10114.7" "11210.1" "11372.7" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "311.563" "46" "22" "144" "22" "520" "57.3" "5.41" "573.60" "22" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "13" "0" "0.979" "1.043" "1.003" "1.021" "1.017" "1.059" "1.086" "1.083" "0.522" "19166.5" "18769.5" "19981.4" "19224.1" "19575.6" "19500.2" "20291.7" "20808.4" "20762.7" "10007.4" "" "" "" "" "" "" "" "" "" "" "16996.5" "15547.7" "17434.7" "14377.1" "16323.4" "17913.1" "17149.7" "17199.6" "19042.2" "10007.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "310.705" "76" "27" "164" "20" "364" "39.4" "6.87" "727.02" "27" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "0" "1.052" "1.005" "1.083" "1.070" "1.032" "1.104" "1.074" "1.026" "0.605" "7241.2" "7614.2" "7279.6" "7839.9" "7749.0" "7474.5" "7991.1" "7773.7" "7426.7" "4383.1" "" "" "" "" "" "" "" "" "" "" "6421.3" "6307.3" "6351.8" "5863.2" "6461.6" "6866.2" "6753.8" "6425.5" "6811.3" "4383.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339242402032558616" "False" "High" "IsMasterProtein" "P05091" "Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2" "0.000" "False" "309.129" "48" "22" "103" "21" "517" "56.3" "7.05" "454.57" "22" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00171" "217" "ENSG00000111275" "ALDH2" "B4DW54; E7EUE5; hsa:217; P05091; Q03639; Q6IB13; Q6IV71" "Mitochondrial protein degradation; Smooth Muscle Contraction; Ethanol oxidation; Metabolism of serotonin" "Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity" "8" "1" "0.996" "1.043" "1.043" "1.038" "1.062" "1.066" "1.135" "1.047" "0.439" "11580.1" "11537.8" "12081.2" "12072.7" "12018.8" "12294.0" "12339.3" "13144.5" "12121.5" "5078.5" "" "" "" "" "" "" "" "" "" "" "10269.0" "9557.3" "10541.5" "9028.8" "10022.0" "11293.4" "10428.7" "10864.9" "11117.1" "5078.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "308.733" "58" "26" "160" "12" "475" "51.9" "8.06" "593.64" "26" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "7" "17" "0.985" "1.024" "0.969" "0.980" "1.009" "1.000" "1.028" "1.022" "0.540" "19442.3" "19144.9" "19912.9" "18837.7" "19060.6" "19614.0" "19448.5" "19987.4" "19878.8" "10507.6" "" "" "" "" "" "" "" "" "" "" "17241.0" "15858.7" "17375.0" "14088.1" "15894.0" "18017.7" "16437.1" "16521.0" "18231.6" "10507.6" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "307.274" "79" "19" "110" "19" "289" "32.1" "6.95" "468.45" "19" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "VEGFA-VEGFR2 signaling" "6" "0" "1.078" "1.027" "1.019" "1.099" "1.060" "1.067" "1.129" "1.010" "0.520" "7711.8" "8310.8" "7920.7" "7862.2" "8474.8" "8174.2" "8226.8" "8704.4" "7790.0" "4013.5" "" "" "" "" "" "" "" "" "" "" "6838.7" "6884.3" "6911.2" "5879.9" "7066.8" "7508.9" "6953.0" "7194.8" "7144.5" "4013.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "303.925" "44" "30" "89" "28" "845" "95.9" "6.80" "353.58" "30" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "ABC-family proteins mediated transport" "IL-18 signaling pathway" "2" "1" "0.951" "0.967" "1.029" "0.990" "0.999" "1.026" "1.026" "0.984" "0.621" "10210.9" "9705.6" "9877.0" "10506.2" "10106.9" "10198.8" "10477.5" "10480.2" "10042.8" "6337.0" "" "" "" "" "" "" "" "" "" "" "9054.8" "8039.6" "8618.2" "7857.3" "8427.8" "9368.8" "8855.2" "8662.6" "9210.6" "6337.0" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "303.807" "49" "25" "127" "17" "623" "69.6" "8.59" "517.50" "25" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "8" "0.988" "1.005" "0.935" "0.956" "0.979" "0.944" "0.942" "0.954" "1.179" "14025.8" "13851.9" "14103.0" "13111.5" "13406.2" "13729.8" "13240.0" "13218.8" "13375.2" "16540.9" "" "" "" "" "" "" "" "" "" "" "12437.8" "11474.2" "12305.5" "9805.7" "11178.9" "12612.4" "11189.9" "10926.3" "12266.9" "16540.9" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "302.301" "49" "27" "101" "27" "548" "62.9" "6.25" "421.01" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response" "2" "0" "1.002" "0.996" "1.038" "1.028" "1.000" "0.990" "1.053" "0.975" "0.555" "11280.7" "11298.6" "11230.5" "11704.5" "11601.0" "11283.8" "11169.5" "11879.4" "10994.9" "6265.1" "" "" "" "" "" "" "" "" "" "" "10003.5" "9359.2" "9799.1" "8753.4" "9673.6" "10365.5" "9440.0" "9819.2" "10083.9" "6265.1" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "301.752" "31" "26" "70" "25" "959" "106.4" "6.39" "295.72" "26" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "Mitochondrial protein degradation" "" "1" "1" "1.043" "1.038" "1.073" "1.079" "1.066" "1.040" "1.056" "0.996" "0.440" "9383.3" "9787.0" "9744.0" "10071.3" "10120.8" "10005.1" "9762.5" "9909.2" "9347.2" "4126.2" "" "" "" "" "" "" "" "" "" "" "8320.9" "8107.1" "8502.1" "7532.0" "8439.4" "9190.8" "8250.9" "8190.7" "8572.7" "4126.2" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "301.677" "58" "24" "165" "19" "372" "38.7" "9.13" "628.11" "24" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "mRNA processing" "6" "5" "1.007" "1.053" "0.948" "0.964" "1.048" "0.900" "0.924" "0.995" "1.148" "12766.8" "12859.0" "13442.7" "12098.6" "12302.1" "13374.6" "11487.5" "11791.9" "12703.7" "14656.5" "" "" "" "" "" "" "" "" "" "" "11321.3" "10651.8" "11729.4" "9048.2" "10258.3" "12286.1" "9708.8" "9746.8" "11651.0" "14656.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "299.646" "53" "26" "174" "26" "425" "47.0" "7.23" "658.52" "26" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Purine ribonucleoside monophosphate biosynthesis" "Metabolic reprogramming in colon cancer" "2" "0" "1.043" "1.078" "1.026" "1.040" "0.981" "1.029" "1.060" "1.095" "0.502" "17683.0" "18447.7" "19058.0" "18144.5" "18382.5" "17347.5" "18188.8" "18736.3" "19369.8" "8883.5" "" "" "" "" "" "" "" "" "" "" "15680.9" "15281.2" "16629.1" "13569.7" "15328.5" "15935.6" "15372.4" "15486.8" "17764.7" "8883.5" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "299.029" "59" "27" "105" "26" "505" "56.7" "6.35" "417.20" "27" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "Prion disease pathway" "4" "0" "1.043" "1.052" "0.989" "1.032" "1.077" "1.034" "0.961" "1.074" "2.227" "11535.7" "12037.2" "12133.9" "11413.0" "11904.6" "12427.3" "11930.7" "11091.2" "12387.3" "25693.9" "" "" "" "" "" "" "" "" "" "" "10229.7" "9971.0" "10587.4" "8535.4" "9926.8" "11415.9" "10083.3" "9167.7" "11360.8" "25693.9" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "297.752" "41" "30" "60" "30" "875" "100.6" "5.22" "264.23" "30" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Antigen processing: Ubiquitination & Proteasome degradation" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "5" "0" "0.994" "0.982" "0.977" "0.992" "0.974" "0.976" "0.995" "0.974" "0.812" "7417.2" "7369.8" "7285.0" "7247.7" "7360.1" "7227.6" "7240.8" "7383.2" "7227.2" "6024.5" "" "" "" "" "" "" "" "" "" "" "6577.4" "6104.7" "6356.5" "5420.3" "6137.3" "6639.3" "6119.6" "6102.7" "6628.3" "6024.5" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "297.336" "70" "23" "159" "23" "338" "35.5" "8.68" "609.03" "23" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Mitochondrial protein degradation; Gluconeogenesis; Citric acid cycle (TCA cycle)" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "10" "0" "1.032" "1.058" "1.026" "1.047" "1.042" "1.044" "1.050" "1.028" "0.452" "17369.6" "17931.6" "18382.4" "17828.7" "18193.6" "18101.6" "18137.3" "18232.8" "17850.5" "7857.3" "" "" "" "" "" "" "" "" "" "" "15403.0" "14853.7" "16039.5" "13333.5" "15171.0" "16628.3" "15328.9" "15070.7" "16371.4" "7857.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "296.520" "42" "22" "86" "22" "613" "66.9" "8.95" "368.32" "22" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "3" "0" "0.992" "1.006" "0.973" "0.976" "0.976" "0.961" "1.026" "0.998" "0.309" "13333.9" "13230.2" "13420.4" "12970.1" "13008.7" "13018.0" "12815.5" "13681.8" "13302.3" "4126.5" "" "" "" "" "" "" "" "" "" "" "11824.2" "10959.2" "11709.9" "9699.9" "10847.5" "11958.5" "10831.2" "11309.0" "12200.1" "4126.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "295.561" "80" "19" "176" "17" "289" "32.6" "5.86" "687.86" "19" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "" "2" "2" "0.937" "0.961" "0.937" "0.960" "1.014" "0.908" "0.960" "0.969" "0.478" "22125.9" "20732.8" "21269.6" "20730.6" "21248.1" "22435.1" "20090.6" "21251.2" "21432.2" "10586.2" "" "" "" "" "" "" "" "" "" "" "19620.8" "17174.0" "18558.7" "15503.7" "17718.0" "20609.1" "16979.7" "17565.6" "19656.2" "10586.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "295.287" "56" "27" "113" "27" "561" "64.3" "6.86" "422.91" "27" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "6" "0" "1.026" "1.056" "1.050" "1.070" "1.067" "1.096" "1.140" "1.131" "0.605" "12939.2" "13282.0" "13664.4" "13587.0" "13840.1" "13805.8" "14179.0" "14753.3" "14638.6" "7829.5" "" "" "" "" "" "" "" "" "" "" "11474.2" "11002.2" "11922.9" "10161.3" "11540.8" "12682.1" "11983.5" "12194.7" "13425.6" "7829.5" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "295.266" "35" "46" "74" "45" "1512" "170.5" "7.33" "284.13" "46" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "6" "1" "1.038" "0.975" "1.058" "1.002" "0.988" "1.085" "0.548" "1.109" "9.851" "4756.1" "4936.6" "4634.8" "5029.8" "4766.1" "4700.1" "5158.6" "2605.0" "5274.5" "46850.4" "" "" "" "" "" "" "" "" "" "" "4217.6" "4089.3" "4044.1" "3761.6" "3974.3" "4317.5" "4359.8" "2153.2" "4837.4" "46850.4" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "295.018" "46" "26" "89" "26" "616" "68.1" "7.21" "366.22" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "SUMOylation of DNA damage response and repair proteins; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "38" "0" "1.025" "1.023" "1.279" "1.392" "1.385" "2.259" "2.336" "2.210" "1.778" "8552.9" "8770.4" "8751.0" "10937.1" "11904.9" "11842.4" "19322.7" "19980.0" "18900.8" "15208.9" "" "" "" "" "" "" "" "" "" "" "7584.6" "7265.0" "7635.7" "8179.5" "9927.1" "10878.6" "16330.7" "16514.9" "17334.6" "15208.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "293.501" "36" "39" "67" "39" "1270" "140.9" "6.84" "272.60" "39" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "mRNA Splicing - Major Pathway; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "MECP2 and associated Rett syndrome; mRNA processing" "6" "0" "1.030" "0.984" "1.053" "1.022" "0.962" "1.122" "1.000" "1.054" "1.926" "5500.8" "5664.0" "5410.7" "5791.4" "5622.8" "5289.1" "6174.5" "5500.5" "5797.3" "10592.8" "" "" "" "" "" "" "" "" "" "" "4878.0" "4691.7" "4721.1" "4331.2" "4688.6" "4858.6" "5218.5" "4546.6" "5316.9" "10592.8" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "293.238" "50" "45" "94" "31" "913" "103.9" "7.37" "369.81" "45" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "14" "1.003" "0.989" "0.997" "1.008" "0.998" "0.994" "1.022" "0.949" "0.618" "11575.5" "11605.7" "11445.6" "11538.6" "11667.0" "11548.5" "11504.2" "11835.5" "10989.4" "7151.4" "" "" "" "" "" "" "" "" "" "" "10264.9" "9613.5" "9986.8" "8629.3" "9728.7" "10608.6" "9722.9" "9782.9" "10078.8" "7151.4" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "292.109" "48" "26" "77" "26" "640" "71.2" "5.29" "337.06" "26" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "" "2" "0" "0.993" "1.016" "0.971" "0.939" "0.928" "0.892" "0.929" "0.907" "0.701" "10591.5" "10516.0" "10756.5" "10289.1" "9948.0" "9829.0" "9442.8" "9835.6" "9604.7" "7428.8" "" "" "" "" "" "" "" "" "" "" "9392.3" "8710.9" "9385.6" "7694.9" "8295.3" "9029.1" "7980.7" "8129.8" "8808.8" "7428.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5217508454541550081" "False" "High" "IsMasterProtein" "P50453" "Serpin B9 OS=Homo sapiens OX=9606 GN=SERPINB9 PE=1 SV=1" "0.000" "False" "291.448" "63" "24" "123" "23" "376" "42.4" "5.86" "548.81" "24" "other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5272" "ENSG00000170542" "SERPINB9" "B2RBW3; hsa:5272; P50453; Q5TD03" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "2" "1" "1.103" "1.157" "1.053" "1.154" "1.065" "1.077" "1.103" "1.123" "0.544" "16489.7" "18189.3" "19075.0" "17366.4" "19028.4" "17569.8" "17759.9" "18194.6" "18517.7" "8965.5" "" "" "" "" "" "" "" "" "" "" "14622.8" "15067.1" "16643.9" "12987.7" "15867.1" "16139.8" "15010.0" "15039.1" "16983.2" "8965.5" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "291.244" "40" "20" "92" "20" "647" "69.0" "7.84" "392.13" "20" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "8" "0" "1.048" "1.058" "1.064" "1.085" "1.059" "1.056" "1.028" "1.048" "0.437" "9905.2" "10379.5" "10481.0" "10539.7" "10748.7" "10485.0" "10460.8" "10181.3" "10383.1" "4327.2" "" "" "" "" "" "" "" "" "" "" "8783.7" "8597.9" "9145.1" "7882.3" "8963.0" "9631.6" "8841.0" "8415.5" "9522.7" "4327.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "290.824" "73" "15" "157" "15" "261" "28.8" "4.69" "602.32" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "47" "0" "1.027" "1.041" "1.044" "1.050" "1.065" "1.089" "1.131" "1.078" "0.563" "21696.3" "22287.0" "22581.2" "22642.0" "22779.1" "23102.4" "23634.7" "24541.7" "23395.7" "12218.2" "" "" "" "" "" "" "" "" "" "" "19239.9" "18461.4" "19703.2" "16933.2" "18994.6" "21222.1" "19975.1" "20285.5" "21457.1" "12218.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "288.782" "65" "39" "90" "38" "607" "69.2" "6.18" "336.37" "39" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "1" "1.127" "1.022" "0.777" "1.300" "0.790" "1.008" "1.217" "1.025" "0.476" "10998.7" "12395.7" "11241.9" "8546.1" "14299.3" "8685.5" "11091.3" "13384.8" "11278.8" "5230.1" "" "" "" "" "" "" "" "" "" "" "9753.4" "10268.0" "9809.1" "6391.4" "11923.7" "7978.6" "9373.9" "11063.4" "10344.2" "5230.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "288.282" "55" "28" "83" "28" "611" "69.2" "6.18" "314.02" "28" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "12" "0" "1.027" "1.047" "1.012" "1.050" "1.041" "1.070" "1.073" "1.011" "0.705" "8711.3" "8942.2" "9121.3" "8813.9" "9144.4" "9067.1" "9321.5" "9344.2" "8803.8" "6143.6" "" "" "" "" "" "" "" "" "" "" "7725.0" "7407.2" "7958.8" "6591.6" "7625.2" "8329.1" "7878.2" "7723.6" "8074.3" "6143.6" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "288.249" "41" "31" "90" "31" "908" "100.1" "5.20" "339.13" "31" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Ub-specific processing proteases; Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "65" "0" "0.997" "1.038" "1.043" "1.091" "1.105" "1.136" "1.138" "1.105" "0.803" "11103.4" "11069.3" "11528.9" "11582.1" "12117.7" "12264.7" "12615.3" "12638.3" "12268.4" "8915.3" "" "" "" "" "" "" "" "" "" "" "9846.2" "9169.2" "10059.6" "8661.9" "10104.5" "11266.5" "10662.0" "10446.4" "11251.8" "8915.3" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "288.132" "65" "24" "82" "24" "439" "49.2" "5.24" "302.87" "24" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.024" "1.018" "1.021" "1.057" "1.023" "1.071" "1.082" "1.100" "0.771" "8791.9" "8998.7" "8947.3" "8974.5" "9292.6" "8990.6" "9416.1" "9508.8" "9669.6" "6776.7" "" "" "" "" "" "" "" "" "" "" "7796.5" "7454.1" "7807.0" "6711.7" "7748.8" "8258.9" "7958.1" "7859.7" "8868.4" "6776.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "287.393" "61" "32" "101" "13" "499" "55.7" "5.62" "390.73" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "4" "23" "0.991" "1.111" "0.982" "1.031" "1.020" "1.050" "1.071" "1.142" "0.598" "11676.9" "11567.7" "12969.9" "11462.3" "12033.4" "11907.1" "12264.9" "12509.4" "13338.4" "6982.0" "" "" "" "" "" "" "" "" "" "" "10354.9" "9582.1" "11316.9" "8572.3" "10034.2" "10938.0" "10365.8" "10339.9" "12233.2" "6982.0" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "287.351" "58" "29" "64" "29" "655" "70.3" "8.75" "272.89" "29" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "4" "0" "1.023" "1.016" "1.044" "1.059" "0.998" "1.018" "1.011" "0.935" "0.480" "6635.0" "6787.5" "6738.9" "6929.0" "7027.4" "6621.9" "6756.7" "6708.5" "6205.0" "3184.6" "" "" "" "" "" "" "" "" "" "" "5883.8" "5622.4" "5880.0" "5181.9" "5859.9" "6083.0" "5710.5" "5545.0" "5690.8" "3184.6" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "286.660" "60" "26" "81" "26" "417" "48.1" "4.44" "336.38" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "13" "0" "0.895" "0.938" "0.922" "0.874" "1.086" "0.945" "0.996" "1.049" "1.312" "11660.2" "10438.2" "10937.4" "10755.0" "10194.2" "12659.1" "11017.9" "11614.2" "12225.8" "15299.8" "" "" "" "" "" "" "" "" "" "" "10340.0" "8646.5" "9543.4" "8043.3" "8500.6" "11628.8" "9311.9" "9600.0" "11212.7" "15299.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "286.614" "61" "27" "94" "27" "519" "56.1" "7.93" "362.71" "27" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "1.032" "1.000" "1.032" "1.017" "1.005" "0.981" "0.971" "1.043" "0.671" "10737.9" "11081.2" "10734.9" "11079.1" "10920.1" "10792.4" "10531.6" "10429.5" "11196.0" "7200.3" "" "" "" "" "" "" "" "" "" "" "9522.2" "9179.1" "9366.7" "8285.7" "9105.9" "9914.0" "8900.9" "8620.7" "10268.2" "7200.3" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700049213662343528" "False" "High" "IsMasterProtein" "P06396" "Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1" "0.000" "False" "286.579" "37" "29" "116" "29" "782" "85.6" "6.28" "450.36" "29" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "2934" "ENSG00000148180" "GSN" "A2A418; A8MUD1; A8MYN7; B7Z373; B7Z5V1; F5H1A8; hsa:2934; P06396; Q5T0I2; Q8WVV7" "Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins" "Ebola virus infection in host; Regulation of actin cytoskeleton" "6" "0" "1.014" "1.050" "1.022" "1.045" "1.058" "1.087" "1.091" "1.104" "0.615" "12193.9" "12369.9" "12803.9" "12459.3" "12747.2" "12905.2" "13251.2" "13301.8" "13458.1" "7504.7" "" "" "" "" "" "" "" "" "" "" "10813.3" "10246.6" "11172.1" "9317.9" "10629.4" "11854.8" "11199.4" "10994.8" "12343.0" "7504.7" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "286.142" "57" "27" "111" "27" "531" "58.0" "6.68" "427.28" "27" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "1.027" "1.028" "1.046" "1.030" "1.002" "1.042" "1.054" "1.011" "0.558" "13891.8" "14260.6" "14278.4" "14527.4" "14313.8" "13922.5" "14477.3" "14644.5" "14042.5" "7757.2" "" "" "" "" "" "" "" "" "" "" "12319.0" "11812.8" "12458.6" "10864.6" "11935.8" "12789.3" "12235.6" "12104.7" "12878.9" "7757.2" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "285.388" "43" "35" "63" "35" "999" "111.3" "5.22" "264.92" "35" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "VEGFA-VEGFR2 signaling" "3" "0" "1.022" "1.032" "1.020" "1.067" "1.062" "1.111" "1.026" "1.149" "2.322" "5244.6" "5362.5" "5414.0" "5351.9" "5596.6" "5568.2" "5824.4" "5379.4" "6027.5" "12177.2" "" "" "" "" "" "" "" "" "" "" "4650.8" "4442.0" "4724.0" "4002.5" "4666.8" "5115.0" "4922.5" "4446.5" "5528.0" "12177.2" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "285.038" "46" "36" "87" "36" "821" "92.8" "5.41" "331.82" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "11" "0" "0.941" "0.946" "1.030" "1.010" "0.974" "1.322" "1.287" "1.179" "1.356" "9457.1" "8896.5" "8948.6" "9744.3" "9549.1" "9215.0" "12501.5" "12171.6" "11154.2" "12819.5" "" "" "" "" "" "" "" "" "" "" "8386.3" "7369.4" "7808.1" "7287.5" "7962.7" "8465.0" "10565.8" "10060.7" "10229.9" "12819.5" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "283.066" "59" "35" "104" "34" "585" "69.0" "5.87" "399.53" "35" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "" "3" "1" "0.993" "0.973" "0.975" "0.968" "1.017" "0.953" "0.986" "0.932" "0.538" "14209.4" "14117.0" "13820.8" "13850.9" "13758.3" "14445.2" "13543.9" "14011.3" "13242.5" "7639.0" "" "" "" "" "" "" "" "" "" "" "12600.6" "11693.8" "12059.3" "10358.6" "11472.6" "13269.5" "11446.7" "11581.4" "12145.2" "7639.0" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "282.882" "67" "22" "77" "22" "389" "44.1" "7.49" "292.84" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "MAPK6/MAPK4 signaling; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "1.038" "1.127" "1.064" "1.119" "1.092" "1.167" "1.135" "1.169" "0.956" "5945.1" "6169.4" "6697.8" "6323.7" "6654.2" "6494.4" "6938.9" "6749.0" "6950.0" "5682.0" "" "" "" "" "" "" "" "" "" "" "5272.0" "5110.5" "5844.1" "4729.3" "5548.7" "5965.9" "5864.5" "5578.5" "6374.1" "5682.0" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "281.583" "44" "36" "78" "36" "906" "102.4" "5.27" "304.72" "36" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.014" "1.010" "0.988" "0.998" "1.020" "0.975" "0.994" "0.915" "1.059" "7211.8" "7313.8" "7286.7" "7125.8" "7195.5" "7358.0" "7034.4" "7168.4" "6602.3" "7639.2" "" "" "" "" "" "" "" "" "" "" "6395.2" "6058.4" "6358.0" "5329.1" "6000.1" "6759.1" "5945.2" "5925.2" "6055.2" "7639.2" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "281.109" "25" "45" "65" "45" "2225" "242.8" "6.46" "248.33" "45" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Pyrimidine biosynthesis" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "4" "0" "1.232" "0.901" "1.149" "1.059" "0.997" "1.514" "1.134" "1.322" "3.697" "3161.9" "3894.8" "2849.4" "3634.2" "3347.1" "3151.3" "4785.6" "3586.2" "4180.9" "11688.2" "" "" "" "" "" "" "" "" "" "" "2803.9" "3226.3" "2486.3" "2717.9" "2791.0" "2894.8" "4044.6" "2964.3" "3834.5" "11688.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "279.394" "42" "46" "77" "46" "1134" "123.7" "5.66" "293.11" "46" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Platelet degranulation ; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "18" "0" "1.040" "0.992" "1.066" "1.042" "1.031" "1.033" "1.043" "0.999" "0.531" "6639.1" "6904.9" "6585.4" "7080.2" "6915.1" "6845.8" "6858.5" "6925.1" "6633.1" "3528.0" "" "" "" "" "" "" "" "" "" "" "5887.4" "5719.6" "5746.0" "5295.1" "5766.3" "6288.7" "5796.5" "5724.1" "6083.4" "3528.0" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "278.748" "39" "24" "159" "17" "558" "63.1" "8.32" "564.51" "24" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; TP53 Regulates Metabolic Genes" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "13" "6" "1.002" "1.010" "0.993" "0.976" "0.986" "0.989" "1.003" "0.970" "0.542" "19261.6" "19293.4" "19459.2" "19123.7" "18797.9" "18998.0" "19045.9" "19326.5" "18687.7" "10442.7" "" "" "" "" "" "" "" "" "" "" "17080.8" "15981.7" "16979.1" "14302.0" "15674.9" "17451.8" "16096.8" "15974.7" "17139.2" "10442.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "278.150" "67" "22" "60" "22" "459" "50.9" "4.73" "262.85" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "0.998" "0.971" "0.993" "0.979" "1.007" "0.996" "0.983" "0.998" "0.700" "7592.4" "7575.4" "7370.6" "7540.5" "7436.3" "7643.9" "7560.5" "7465.5" "7579.8" "5316.4" "" "" "" "" "" "" "" "" "" "" "6732.8" "6275.1" "6431.2" "5639.3" "6200.9" "7021.7" "6389.8" "6170.7" "6951.7" "5316.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "276.393" "63" "25" "111" "12" "406" "46.1" "5.48" "414.26" "25" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "13" "14" "1.025" "1.039" "1.074" "1.047" "1.050" "1.077" "1.015" "1.007" "1.956" "14219.1" "14581.5" "14770.4" "15278.4" "14884.0" "14936.2" "15321.0" "14425.6" "14317.7" "27812.7" "" "" "" "" "" "" "" "" "" "" "12609.2" "12078.6" "12887.9" "11426.2" "12411.3" "13720.6" "12948.7" "11923.8" "13131.3" "27812.7" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "276.327" "39" "33" "71" "33" "1058" "117.8" "5.76" "275.21" "33" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "5" "0" "1.036" "0.973" "1.081" "0.991" "0.932" "1.022" "0.521" "0.961" "8.849" "3140.6" "3254.0" "3055.7" "3395.6" "3112.4" "2926.7" "3210.5" "1635.8" "3017.0" "27789.7" "" "" "" "" "" "" "" "" "" "" "2785.0" "2695.4" "2666.2" "2539.5" "2595.4" "2688.5" "2713.4" "1352.1" "2767.0" "27789.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "276.170" "36" "44" "53" "44" "1498" "167.3" "5.44" "219.64" "44" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "RND2 GTPase cycle" "" "1" "0" "0.988" "0.944" "0.975" "0.935" "0.910" "0.963" "0.964" "0.988" "0.994" "6803.8" "6719.0" "6422.3" "6633.2" "6359.2" "6192.5" "6552.6" "6556.8" "6721.0" "6762.0" "" "" "" "" "" "" "" "" "" "" "6033.4" "5565.7" "5603.7" "4960.8" "5302.7" "5688.5" "5538.0" "5419.7" "6164.1" "6762.0" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "275.401" "67" "24" "107" "24" "433" "48.6" "5.95" "435.45" "24" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Separation of Sister Chromatids; Neutrophil degranulation; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.032" "1.042" "1.104" "1.112" "1.050" "1.179" "1.155" "1.154" "0.789" "9470.9" "9777.4" "9871.2" "10458.0" "10534.6" "9943.2" "11169.3" "10943.5" "10928.9" "7473.9" "" "" "" "" "" "" "" "" "" "" "8398.6" "8099.1" "8613.1" "7821.2" "8784.4" "9133.9" "9439.8" "9045.5" "10023.3" "7473.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "275.226" "36" "36" "71" "36" "1304" "145.7" "7.09" "279.48" "36" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "5" "0" "0.964" "0.950" "0.957" "0.917" "0.950" "0.912" "0.887" "0.877" "1.458" "6238.8" "6017.3" "5928.9" "5970.8" "5723.3" "5924.9" "5690.1" "5533.6" "5468.8" "9098.3" "" "" "" "" "" "" "" "" "" "" "5532.5" "4984.5" "5173.3" "4465.3" "4772.5" "5442.7" "4809.0" "4573.9" "5015.7" "9098.3" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "275.071" "17" "54" "66" "54" "3753" "422.1" "6.83" "247.01" "54" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "1.076" "1.035" "1.031" "1.081" "0.928" "1.093" "1.097" "1.057" "0.901" "4733.6" "5091.6" "4898.5" "4882.6" "5114.9" "4391.6" "5175.8" "5193.6" "5002.8" "4264.9" "" "" "" "" "" "" "" "" "" "" "4197.7" "4217.6" "4274.2" "3651.5" "4265.2" "4034.2" "4374.4" "4292.8" "4588.3" "4264.9" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "274.475" "37" "31" "73" "30" "978" "105.7" "8.06" "286.67" "31" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "Metabolism of folate and pterines" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "3" "0" "1.026" "1.045" "1.012" "1.030" "1.028" "0.964" "1.013" "0.921" "0.538" "9818.7" "10078.6" "10261.6" "9931.8" "10116.9" "10095.8" "9464.1" "9948.9" "9041.8" "5277.7" "" "" "" "" "" "" "" "" "" "" "8707.0" "8348.6" "8953.8" "7427.7" "8436.1" "9274.1" "7998.6" "8223.5" "8292.6" "5277.7" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "274.273" "48" "34" "81" "34" "747" "85.6" "9.23" "290.90" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "Regulation of TP53 Activity through Phosphorylation; AURKA Activation by TPX2" "Gastric cancer network 1" "3" "0" "0.999" "1.004" "1.010" "0.987" "1.001" "1.046" "1.083" "1.046" "0.543" "9918.9" "9906.0" "9962.2" "10018.7" "9790.6" "9927.6" "10376.9" "10740.7" "10372.6" "5389.1" "" "" "" "" "" "" "" "" "" "" "8795.9" "8205.6" "8692.5" "7492.6" "8164.0" "9119.6" "8770.1" "8877.9" "9513.1" "5389.1" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "272.537" "70" "22" "81" "22" "315" "36.1" "5.08" "317.08" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "21" "0" "1.021" "1.020" "1.032" "1.056" "1.025" "1.017" "1.024" "0.955" "0.646" "9881.0" "10088.1" "10074.3" "10196.4" "10433.7" "10131.1" "10045.7" "10116.3" "9439.6" "6381.3" "" "" "" "" "" "" "" "" "" "" "8762.3" "8356.5" "8790.3" "7625.6" "8700.3" "9306.6" "8490.2" "8361.9" "8657.4" "6381.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "271.266" "31" "23" "64" "23" "876" "97.1" "4.78" "273.18" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Neutrophil degranulation; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Assembly of the ORC complex at the origin of replication; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "15" "0" "1.006" "0.966" "0.990" "0.978" "0.942" "0.882" "0.746" "0.824" "3.523" "5123.4" "5153.2" "4948.1" "5072.7" "5011.4" "4828.5" "4519.6" "3820.8" "4220.2" "18049.1" "" "" "" "" "" "" "" "" "" "" "4543.3" "4268.7" "4317.4" "3793.7" "4178.8" "4435.5" "3819.8" "3158.2" "3870.5" "18049.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "270.430" "38" "33" "83" "33" "950" "108.5" "7.47" "309.45" "33" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "mRNA processing" "3" "0" "1.011" "0.999" "1.052" "1.047" "1.018" "1.035" "1.036" "0.993" "0.664" "7875.1" "7964.2" "7867.6" "8284.4" "8245.7" "8020.5" "8148.9" "8162.5" "7817.2" "5227.0" "" "" "" "" "" "" "" "" "" "" "6983.5" "6597.1" "6864.8" "6195.7" "6875.8" "7367.7" "6887.1" "6746.9" "7169.5" "5227.0" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "269.329" "63" "23" "97" "21" "406" "45.6" "7.55" "370.99" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "65" "0" "1.009" "1.062" "1.101" "1.090" "1.033" "1.152" "1.152" "1.135" "0.656" "9259.1" "9346.7" "9833.7" "10196.1" "10093.0" "9561.9" "10667.6" "10667.6" "10505.9" "6069.9" "" "" "" "" "" "" "" "" "" "" "8210.8" "7742.4" "8580.4" "7625.4" "8416.2" "8783.7" "9015.9" "8817.5" "9635.4" "6069.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "268.440" "53" "25" "100" "25" "483" "53.1" "7.23" "380.80" "25" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "7" "0" "1.012" "1.030" "1.037" "1.021" "1.004" "1.070" "1.062" "1.014" "0.527" "13297.5" "13456.2" "13699.0" "13783.2" "13582.8" "13351.0" "14225.0" "14128.1" "13483.5" "7013.9" "" "" "" "" "" "" "" "" "" "" "11792.0" "11146.5" "11953.0" "10308.0" "11326.2" "12264.4" "12022.4" "11677.9" "12366.3" "7013.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "268.070" "52" "22" "134" "22" "463" "50.9" "5.54" "450.71" "22" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "HCMV Late Events; SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "6" "0" "0.981" "0.984" "0.961" "0.949" "0.954" "0.953" "0.926" "0.939" "1.593" "13622.4" "13364.2" "13403.3" "13090.9" "12922.7" "12995.0" "12981.0" "12609.6" "12785.7" "21703.1" "" "" "" "" "" "" "" "" "" "" "12080.0" "11070.2" "11695.0" "9790.2" "10775.8" "11937.4" "10971.0" "10422.7" "11726.2" "21703.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "264.765" "79" "18" "228" "18" "249" "26.7" "6.90" "971.66" "18" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Glycolysis; Gluconeogenesis" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "10" "0" "0.973" "0.987" "0.976" "0.970" "1.027" "0.975" "0.998" "0.955" "0.522" "26139.8" "25442.2" "25805.6" "25525.3" "25355.8" "26841.6" "25494.8" "26091.9" "24957.7" "13641.8" "" "" "" "" "" "" "" "" "" "" "23180.2" "21075.1" "22516.7" "19089.6" "21143.3" "24657.0" "21547.1" "21566.8" "22889.7" "13641.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "264.635" "23" "38" "65" "36" "2157" "228.7" "9.45" "260.01" "38" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "0.985" "0.980" "0.990" "0.967" "0.967" "0.966" "0.976" "0.975" "0.465" "6175.8" "6082.5" "6049.9" "6115.6" "5972.3" "5970.3" "5966.6" "6029.8" "6023.0" "2869.9" "" "" "" "" "" "" "" "" "" "" "5476.6" "5038.4" "5278.8" "4573.6" "4980.1" "5484.4" "5042.7" "4984.1" "5523.9" "2869.9" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "264.430" "68" "22" "89" "22" "333" "38.4" "5.80" "325.47" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "ABC-family proteins mediated transport; PKR-mediated signaling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "16" "0" "0.983" "1.021" "1.011" "0.994" "0.985" "1.035" "1.036" "1.024" "0.568" "10754.3" "10572.0" "10977.9" "10877.2" "10687.3" "10591.5" "11133.7" "11138.3" "11015.9" "6108.0" "" "" "" "" "" "" "" "" "" "" "9536.7" "8757.3" "9578.7" "8134.7" "8911.8" "9729.5" "9409.8" "9206.6" "10103.1" "6108.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "264.252" "40" "35" "74" "35" "895" "100.2" "5.67" "266.82" "35" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.969" "0.939" "0.930" "0.927" "0.907" "0.882" "0.895" "0.903" "0.730" "5756.0" "5579.6" "5406.2" "5352.8" "5334.6" "5219.7" "5075.4" "5153.8" "5198.1" "4202.6" "" "" "" "" "" "" "" "" "" "" "5104.3" "4621.9" "4717.2" "4003.2" "4448.3" "4794.9" "4289.5" "4260.0" "4767.3" "4202.6" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "263.850" "48" "29" "120" "23" "636" "70.6" "9.50" "430.38" "29" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "13" "7" "1.018" "1.106" "1.046" "1.034" "1.112" "0.988" "0.989" "1.050" "0.722" "11716.6" "11922.4" "12959.6" "12254.0" "12113.6" "13025.4" "11579.6" "11583.9" "12297.6" "8455.5" "" "" "" "" "" "" "" "" "" "" "10390.0" "9875.9" "11307.9" "9164.3" "10101.1" "11965.3" "9786.6" "9574.9" "11278.6" "8455.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "263.113" "51" "24" "63" "24" "624" "70.8" "6.86" "254.00" "24" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "Sulfation biotransformation reaction" "4" "0" "1.051" "1.073" "1.078" "1.094" "1.116" "1.075" "1.104" "1.072" "0.591" "5404.4" "5682.5" "5797.7" "5827.2" "5911.3" "6028.7" "5809.9" "5967.2" "5790.8" "3195.3" "" "" "" "" "" "" "" "" "" "" "4792.5" "4707.1" "5058.8" "4357.9" "4929.2" "5538.0" "4910.3" "4932.3" "5311.0" "3195.3" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "263.091" "48" "24" "50" "24" "631" "71.6" "4.65" "228.61" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "13" "0" "1.056" "1.037" "1.044" "1.051" "1.007" "0.992" "1.013" "1.025" "0.681" "5406.3" "5708.6" "5606.8" "5645.0" "5683.5" "5445.0" "5361.4" "5476.3" "5542.1" "3682.1" "" "" "" "" "" "" "" "" "" "" "4794.2" "4728.7" "4892.2" "4221.7" "4739.3" "5001.9" "4531.2" "4526.5" "5082.8" "3682.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "262.673" "44" "23" "81" "23" "617" "68.3" "5.52" "316.54" "23" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.023" "0.983" "1.029" "1.031" "1.017" "1.002" "1.009" "0.896" "0.683" "7743.7" "7919.3" "7610.1" "7965.6" "7984.8" "7877.2" "7760.1" "7815.9" "6934.9" "5292.3" "" "" "" "" "" "" "" "" "" "" "6866.9" "6559.9" "6640.2" "5957.2" "6658.2" "7236.1" "6558.5" "6460.4" "6360.3" "5292.3" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "261.914" "46" "29" "82" "29" "748" "85.4" "6.76" "318.43" "29" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "Cytosolic tRNA aminoacylation; Signaling by ALK fusions and activated point mutants" "" "2" "0" "1.010" "1.032" "0.982" "1.066" "1.037" "1.094" "1.118" "1.066" "0.587" "8501.7" "8583.0" "8774.2" "8348.3" "9058.8" "8814.0" "9301.1" "9503.9" "9062.4" "4992.1" "" "" "" "" "" "" "" "" "" "" "7539.2" "7109.7" "7655.9" "6243.4" "7553.8" "8096.6" "7860.9" "7855.6" "8311.5" "4992.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "261.746" "51" "18" "70" "18" "529" "56.5" "5.40" "284.60" "18" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "8" "0" "1.019" "0.974" "1.049" "1.067" "1.049" "0.965" "1.001" "0.935" "0.543" "6057.0" "6170.9" "5897.0" "6353.5" "6464.8" "6355.8" "5845.2" "6060.5" "5661.5" "3289.2" "" "" "" "" "" "" "" "" "" "" "5371.2" "5111.7" "5145.4" "4751.6" "5390.8" "5838.5" "4940.2" "5009.5" "5192.4" "3289.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "261.555" "28" "50" "75" "50" "1970" "217.0" "7.37" "276.64" "50" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "44" "0" "1.004" "0.974" "1.018" "1.001" "1.014" "0.851" "0.875" "0.888" "1.096" "7583.4" "7616.6" "7388.2" "7717.4" "7589.3" "7687.9" "6454.9" "6633.2" "6732.1" "8309.6" "" "" "" "" "" "" "" "" "" "" "6724.8" "6309.2" "6446.6" "5771.6" "6328.5" "7062.2" "5455.4" "5482.8" "6174.3" "8309.6" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "260.573" "42" "27" "60" "27" "780" "85.4" "7.61" "254.81" "27" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.913" "0.949" "0.886" "0.796" "0.774" "0.821" "0.774" "0.791" "1.130" "8432.0" "7701.0" "8001.4" "7473.9" "6715.5" "6528.9" "6925.0" "6528.6" "6668.8" "9531.1" "" "" "" "" "" "" "" "" "" "" "7477.4" "6379.1" "6981.6" "5589.5" "5599.8" "5997.5" "5852.8" "5396.3" "6116.2" "9531.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "260.065" "52" "32" "67" "32" "699" "78.8" "7.11" "278.83" "32" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "UDP-derived sugars synthesis in fibroblasts" "4" "0" "1.000" "0.997" "1.035" "1.006" "1.029" "1.015" "1.046" "0.948" "0.573" "8595.0" "8597.2" "8571.3" "8893.9" "8643.8" "8841.6" "8721.0" "8986.8" "8144.1" "4927.9" "" "" "" "" "" "" "" "" "" "" "7621.9" "7121.5" "7478.9" "6651.5" "7207.8" "8122.0" "7370.7" "7428.2" "7469.2" "4927.9" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "259.011" "49" "21" "88" "20" "504" "56.0" "8.53" "335.38" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "13" "2" "1.005" "1.040" "1.014" "1.073" "1.081" "1.036" "1.087" "0.989" "0.436" "8654.9" "8699.2" "9003.1" "8775.0" "9284.7" "9355.8" "8968.2" "9404.2" "8558.6" "3770.0" "" "" "" "" "" "" "" "" "" "" "7675.0" "7206.0" "7855.6" "6562.5" "7742.1" "8594.3" "7579.6" "7773.2" "7849.4" "3770.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "258.315" "42" "39" "181" "38" "710" "76.6" "4.70" "598.88" "39" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "4" "1" "1.015" "1.060" "0.970" "0.956" "0.935" "0.842" "0.863" "0.899" "0.941" "25610.2" "26002.2" "27142.0" "24853.8" "24493.2" "23950.7" "21561.0" "22113.5" "23017.4" "24090.9" "" "" "" "" "" "" "" "" "" "" "22710.6" "21538.9" "23682.7" "18587.3" "20424.0" "22001.4" "18222.5" "18278.4" "21110.1" "24090.9" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "257.767" "48" "25" "99" "18" "589" "65.3" "5.11" "337.33" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "50" "7" "1.030" "1.017" "1.071" "1.030" "1.010" "1.020" "1.020" "0.979" "0.628" "10166.6" "10471.8" "10337.8" "10886.8" "10472.9" "10272.8" "10366.9" "10366.7" "9957.5" "6387.1" "" "" "" "" "" "" "" "" "" "" "9015.6" "8674.3" "9020.2" "8141.9" "8732.9" "9436.7" "8761.6" "8568.8" "9132.4" "6387.1" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "257.172" "60" "32" "124" "32" "534" "60.9" "8.44" "419.81" "32" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.002" "1.037" "1.067" "1.075" "1.055" "1.137" "1.107" "1.119" "0.782" "10878.0" "10901.1" "11278.7" "11604.1" "11693.2" "11481.5" "12363.7" "12039.8" "12170.2" "8506.4" "" "" "" "" "" "" "" "" "" "" "9646.4" "9029.9" "9841.2" "8678.3" "9750.5" "10547.1" "10449.3" "9951.7" "11161.8" "8506.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "256.898" "53" "22" "68" "22" "455" "49.8" "7.61" "289.92" "22" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "16p11.2 distal deletion syndrome" "3" "0" "0.913" "0.961" "0.984" "0.958" "0.928" "1.257" "1.150" "1.161" "2.075" "5157.0" "4706.2" "4958.1" "5075.5" "4940.6" "4786.3" "6480.1" "5928.8" "5985.3" "10701.3" "" "" "" "" "" "" "" "" "" "" "4573.1" "3898.4" "4326.2" "3795.8" "4119.8" "4396.8" "5476.7" "4900.6" "5489.4" "10701.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "256.282" "32" "36" "72" "27" "1231" "141.2" "5.43" "254.79" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "9" "6" "1.014" "1.030" "1.054" "1.048" "1.035" "0.978" "1.040" "0.964" "0.680" "6698.0" "6792.8" "6899.9" "7060.4" "7016.3" "6935.3" "6551.9" "6962.9" "6458.0" "4554.5" "" "" "" "" "" "" "" "" "" "" "5939.7" "5626.8" "6020.5" "5280.3" "5850.6" "6370.8" "5537.4" "5755.3" "5922.9" "4554.5" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "255.567" "34" "45" "57" "45" "1438" "162.1" "5.36" "227.77" "45" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "9" "0" "0.987" "0.939" "1.005" "0.958" "0.962" "0.965" "0.983" "0.992" "0.690" "6370.2" "6288.4" "5984.6" "6403.7" "6105.5" "6125.0" "6145.2" "6264.6" "6316.2" "4396.0" "" "" "" "" "" "" "" "" "" "" "5649.0" "5209.0" "5221.9" "4789.1" "5091.1" "5626.5" "5193.7" "5178.2" "5792.8" "4396.0" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "255.187" "34" "30" "66" "30" "1012" "113.7" "7.20" "259.48" "30" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "" "2" "0" "1.055" "1.068" "1.075" "1.092" "1.098" "1.077" "1.102" "1.052" "0.477" "9265.9" "9778.7" "9898.6" "9957.0" "10119.9" "10172.6" "9984.0" "10206.7" "9748.2" "4418.6" "" "" "" "" "" "" "" "" "" "" "8216.8" "8100.2" "8637.0" "7446.5" "8438.6" "9344.6" "8438.1" "8436.6" "8940.4" "4418.6" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "255.159" "45" "21" "63" "21" "567" "60.2" "4.78" "279.57" "21" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "1.062" "1.029" "1.015" "1.056" "1.008" "0.934" "0.995" "0.946" "0.513" "6686.4" "7103.7" "6877.9" "6787.8" "7058.1" "6738.6" "6242.0" "6652.2" "6327.5" "3432.4" "" "" "" "" "" "" "" "" "" "" "5929.3" "5884.4" "6001.3" "5076.3" "5885.5" "6190.2" "5275.5" "5498.5" "5803.2" "3432.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "253.658" "49" "37" "84" "37" "776" "89.6" "8.00" "314.35" "37" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Circadian Clock; Regulation of PLK1 Activity at G2/M Transition; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "41" "0" "1.018" "1.034" "1.026" "1.060" "1.060" "1.065" "1.086" "1.007" "0.697" "9835.5" "10012.9" "10170.6" "10089.5" "10420.8" "10425.7" "10475.6" "10677.7" "9904.9" "6856.4" "" "" "" "" "" "" "" "" "" "" "8721.9" "8294.2" "8874.3" "7545.6" "8689.6" "9577.2" "8853.6" "8825.8" "9084.2" "6856.4" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "252.014" "64" "11" "73" "9" "286" "32.9" "5.69" "358.49" "11" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "Sensory processing of sound by inner hair cells of the cochlea; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "8" "0" "1.029" "1.032" "1.033" "1.040" "1.080" "1.061" "1.089" "1.058" "0.669" "5628.7" "5790.9" "5807.3" "5817.2" "5854.8" "6077.5" "5971.5" "6131.3" "5957.3" "3765.0" "" "" "" "" "" "" "" "" "" "" "4991.4" "4796.9" "5067.2" "4350.5" "4882.1" "5582.9" "5046.9" "5068.0" "5463.6" "3765.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "251.532" "50" "28" "78" "28" "591" "66.6" "6.46" "300.29" "28" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "0.990" "1.013" "0.955" "0.998" "0.996" "1.407" "1.389" "1.348" "0.824" "6801.2" "6730.7" "6890.0" "6497.2" "6784.9" "6776.1" "9567.5" "9443.8" "9168.3" "5605.4" "" "" "" "" "" "" "" "" "" "" "6031.2" "5575.4" "6011.9" "4859.0" "5657.7" "6224.6" "8086.0" "7806.0" "8408.6" "5605.4" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "250.883" "43" "31" "69" "29" "874" "97.7" "5.47" "259.11" "31" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "VEGFA-VEGFR2 signaling" "3" "2" "1.043" "1.008" "1.029" "1.049" "0.971" "1.017" "0.974" "0.964" "1.008" "5924.3" "6182.0" "5972.3" "6094.2" "6214.8" "5754.7" "6023.8" "5770.1" "5712.0" "5972.2" "" "" "" "" "" "" "" "" "" "" "5253.6" "5120.8" "5211.2" "4557.6" "5182.3" "5286.3" "5091.1" "4769.4" "5238.7" "5972.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "250.265" "39" "29" "69" "29" "858" "95.7" "5.03" "271.97" "29" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases" "IL-18 signaling pathway" "3" "0" "1.028" "1.019" "1.039" "1.029" "1.017" "1.029" "1.023" "0.967" "0.924" "8275.1" "8506.0" "8434.6" "8596.9" "8512.3" "8419.3" "8517.4" "8469.5" "7998.3" "7643.0" "" "" "" "" "" "" "" "" "" "" "7338.2" "7045.9" "7359.6" "6429.4" "7098.1" "7734.0" "7198.5" "7000.6" "7335.5" "7643.0" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "249.926" "49" "21" "65" "21" "572" "62.3" "6.38" "264.68" "21" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Recycling pathway of L1; CRMPs in Sema3A signaling" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "4" "0" "1.021" "1.018" "1.057" "1.068" "1.042" "1.031" "1.053" "1.010" "0.539" "6625.7" "6765.3" "6746.2" "7006.0" "7074.2" "6902.9" "6832.6" "6975.1" "6695.1" "3571.1" "" "" "" "" "" "" "" "" "" "" "5875.5" "5604.0" "5886.4" "5239.6" "5898.9" "6341.1" "5774.7" "5765.4" "6140.3" "3571.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.000" "False" "249.746" "35" "29" "42" "29" "1087" "120.9" "5.06" "175.17" "29" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "20" "0" "1.032" "1.021" "0.983" "0.982" "1.009" "0.946" "0.873" "0.966" "2.915" "2949.1" "3044.4" "3011.6" "2899.5" "2895.9" "2974.8" "2788.7" "2574.3" "2847.8" "8596.6" "" "" "" "" "" "" "" "" "" "" "2615.2" "2521.8" "2627.8" "2168.5" "2414.8" "2732.7" "2356.9" "2127.8" "2611.8" "8596.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "248.952" "43" "19" "87" "15" "524" "58.0" "5.96" "335.08" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOU GTPase cycle; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Ephrin signaling; Sema3A PAK dependent Axon repulsion; Smooth Muscle Contraction; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Nef and signal transduction; Stimulation of the cell death response by PAK-2p34" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "45" "5" "1.040" "1.047" "1.032" "1.054" "1.010" "1.022" "1.045" "1.046" "0.528" "12681.7" "13191.8" "13271.7" "13089.9" "13367.6" "12811.9" "12958.8" "13246.2" "13263.8" "6689.9" "" "" "" "" "" "" "" "" "" "" "11245.9" "10927.5" "11580.2" "9789.5" "11146.7" "11769.1" "10952.3" "10948.9" "12164.7" "6689.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "248.215" "73" "21" "246" "14" "245" "27.7" "4.79" "915.56" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Negative regulation of NOTCH4 signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "40" "4" "0.992" "1.006" "0.949" "1.009" "0.978" "0.926" "0.962" "0.974" "0.534" "20583.3" "20424.5" "20703.1" "19537.5" "20774.5" "20125.2" "19068.1" "19806.2" "20044.1" "10983.3" "" "" "" "" "" "" "" "" "" "" "18252.8" "16918.7" "18064.5" "14611.5" "17323.1" "18487.2" "16115.6" "16371.2" "18383.2" "10983.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "248.099" "62" "24" "82" "13" "447" "50.6" "5.14" "329.54" "24" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "RAB GEFs exchange GTP for GDP on RABs" "Ciliary landscape; Airway smooth muscle cell contraction" "3" "0" "1.031" "1.043" "1.027" "1.061" "1.058" "1.050" "1.061" "0.980" "0.542" "5251.1" "5414.4" "5474.5" "5391.7" "5570.2" "5555.3" "5515.5" "5569.5" "5144.8" "2844.1" "" "" "" "" "" "" "" "" "" "" "4656.6" "4485.0" "4776.8" "4032.2" "4644.8" "5103.2" "4661.5" "4603.6" "4718.5" "2844.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "245.745" "27" "42" "78" "35" "1599" "175.4" "5.33" "265.24" "42" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "20" "6" "1.050" "0.919" "1.010" "0.966" "0.905" "0.985" "0.649" "0.969" "6.398" "4040.3" "4241.9" "3711.4" "4080.0" "3903.2" "3656.5" "3981.6" "2623.7" "3915.5" "25848.5" "" "" "" "" "" "" "" "" "" "" "3582.8" "3513.8" "3238.4" "3051.3" "3254.7" "3358.9" "3365.1" "2168.7" "3591.0" "25848.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "244.650" "53" "28" "78" "28" "522" "56.0" "8.78" "286.10" "28" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.940" "0.927" "0.831" "0.843" "0.821" "0.823" "0.841" "0.890" "0.716" "10668.2" "10027.9" "9888.3" "8866.7" "8988.5" "8761.6" "8775.6" "8967.7" "9498.0" "7635.2" "" "" "" "" "" "" "" "" "" "" "9460.3" "8306.6" "8628.0" "6631.1" "7495.2" "8048.5" "7416.8" "7412.5" "8711.0" "7635.2" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "244.350" "55" "25" "130" "23" "432" "47.7" "6.34" "462.76" "25" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "11" "2" "1.049" "1.002" "1.062" "1.054" "1.047" "1.005" "1.041" "0.947" "0.526" "13740.2" "14415.6" "13767.8" "14598.7" "14478.0" "14388.1" "13811.5" "14296.9" "13018.8" "7228.9" "" "" "" "" "" "" "" "" "" "" "12184.5" "11941.2" "12013.0" "10917.9" "12072.7" "13217.1" "11672.9" "11817.4" "11940.0" "7228.9" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "243.640" "71" "13" "58" "13" "261" "26.9" "7.78" "252.39" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "8" "0" "1.057" "1.071" "1.106" "1.115" "1.012" "1.103" "1.076" "0.993" "0.441" "6045.3" "6390.5" "6472.2" "6685.5" "6738.8" "6118.9" "6670.3" "6503.8" "6002.8" "2666.3" "" "" "" "" "" "" "" "" "" "" "5360.8" "5293.6" "5647.3" "4999.9" "5619.2" "5620.9" "5637.5" "5375.9" "5505.4" "2666.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "243.220" "60" "21" "65" "21" "475" "52.8" "5.97" "260.79" "21" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "Paracetamol ADME; Glutathione synthesis and recycling" "" "2" "0" "1.025" "1.081" "0.968" "0.992" "0.952" "1.119" "1.101" "1.146" "0.931" "6290.8" "6447.4" "6801.6" "6092.3" "6238.0" "5986.4" "7041.1" "6923.8" "7208.5" "5854.9" "" "" "" "" "" "" "" "" "" "" "5578.5" "5340.7" "5934.8" "4556.3" "5201.6" "5499.2" "5950.8" "5723.0" "6611.2" "5854.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "243.187" "52" "35" "84" "35" "689" "78.8" "6.05" "300.87" "35" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.020" "1.032" "1.059" "1.052" "1.030" "1.054" "1.066" "0.999" "0.562" "9247.4" "9428.7" "9540.6" "9789.7" "9731.9" "9522.8" "9744.3" "9859.0" "9239.9" "5194.3" "" "" "" "" "" "" "" "" "" "" "8200.4" "7810.3" "8324.6" "7321.4" "8115.1" "8747.7" "8235.5" "8149.1" "8474.3" "5194.3" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "241.812" "35" "33" "64" "33" "1087" "123.8" "6.32" "245.07" "33" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "1.029" "1.014" "1.054" "1.077" "1.087" "1.034" "1.026" "0.941" "0.845" "4430.1" "4557.8" "4491.0" "4667.3" "4769.6" "4815.0" "4578.9" "4547.1" "4169.6" "3744.0" "" "" "" "" "" "" "" "" "" "" "3928.5" "3775.4" "3918.6" "3490.6" "3977.2" "4423.2" "3869.9" "3758.5" "3824.1" "3744.0" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "240.656" "41" "31" "50" "31" "913" "101.3" "5.45" "209.95" "31" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "" "Ectoderm differentiation" "1" "0" "0.986" "1.013" "1.004" "1.024" "1.052" "0.992" "1.021" "0.984" "0.515" "7165.7" "7065.4" "7255.4" "7193.7" "7339.5" "7535.0" "7104.9" "7317.8" "7054.3" "3690.7" "" "" "" "" "" "" "" "" "" "" "6354.4" "5852.6" "6330.7" "5379.9" "6120.1" "6921.7" "6004.8" "6048.7" "6469.8" "3690.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "240.090" "55" "20" "75" "20" "418" "47.3" "5.88" "316.66" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Physico-chemical features and toxicity-associated pathways" "6" "0" "1.029" "1.042" "1.037" "1.100" "1.030" "1.019" "1.031" "0.967" "0.544" "9482.7" "9756.6" "9880.9" "9835.5" "10432.0" "9771.8" "9663.4" "9777.6" "9169.0" "5159.6" "" "" "" "" "" "" "" "" "" "" "8409.0" "8081.9" "8621.6" "7355.7" "8698.9" "8976.5" "8167.1" "8081.9" "8409.3" "5159.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "239.851" "58" "18" "224" "16" "334" "36.6" "6.05" "771.95" "18" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Pyruvate metabolism" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "1.028" "1.065" "1.032" "1.072" "1.064" "1.053" "1.085" "1.016" "0.503" "19125.4" "19665.4" "20373.9" "19739.5" "20494.6" "20345.7" "20143.3" "20754.6" "19427.8" "9613.1" "" "" "" "" "" "" "" "" "" "" "16960.0" "16289.8" "17777.2" "14762.5" "17089.7" "18689.8" "17024.3" "17155.1" "17818.0" "9613.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "239.676" "53" "38" "74" "38" "730" "77.5" "8.70" "228.35" "38" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "4" "0" "1.026" "0.994" "1.061" "0.963" "0.928" "0.974" "0.408" "0.956" "13.419" "3460.6" "3550.0" "3440.2" "3670.3" "3332.5" "3210.2" "3369.5" "1411.5" "3306.7" "46438.9" "" "" "" "" "" "" "" "" "" "" "3068.8" "2940.6" "3001.7" "2744.9" "2778.9" "2948.9" "2847.7" "1166.7" "3032.7" "46438.9" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "239.495" "61" "21" "158" "18" "353" "37.4" "8.95" "543.19" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "4" "0" "1.001" "1.033" "0.963" "0.991" "1.075" "0.934" "0.847" "0.973" "2.558" "7904.4" "7911.4" "8162.0" "7608.3" "7830.8" "8499.7" "7381.2" "6691.4" "7687.8" "20218.6" "" "" "" "" "" "" "" "" "" "" "7009.4" "6553.4" "7121.8" "5690.0" "6529.8" "7807.9" "6238.3" "5530.9" "7050.8" "20218.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "239.050" "54" "22" "58" "22" "510" "54.6" "8.76" "221.52" "22" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "0.966" "0.970" "1.002" "1.004" "1.010" "1.088" "1.082" "1.016" "0.474" "5537.3" "5348.5" "5371.2" "5547.4" "5557.7" "5593.0" "6023.3" "5992.0" "5623.8" "2627.1" "" "" "" "" "" "" "" "" "" "" "4910.3" "4430.4" "4686.6" "4148.7" "4634.4" "5137.8" "5090.7" "4952.8" "5157.8" "2627.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "238.596" "50" "19" "61" "19" "522" "56.2" "8.50" "259.96" "19" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "11" "0" "0.958" "1.002" "0.944" "0.980" "0.973" "0.935" "0.997" "1.036" "0.462" "7841.3" "7510.5" "7857.6" "7402.6" "7687.8" "7626.2" "7335.5" "7821.5" "8123.0" "3626.3" "" "" "" "" "" "" "" "" "" "" "6953.5" "6221.3" "6856.1" "5536.2" "6410.6" "7005.5" "6199.7" "6465.0" "7449.9" "3626.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8881781993375373139" "False" "High" "IsMasterProtein" "Q9H568" "Actin-like protein 8 OS=Homo sapiens OX=9606 GN=ACTL8 PE=1 SV=1" "0.000" "False" "238.563" "56" "19" "87" "19" "366" "41.3" "6.14" "342.91" "19" "cell organization and biogenesis;other biological processes" "cytoskeleton" "" "Pf00022" "81569" "ENSG00000117148" "ACTL8" "hsa:81569; Q13104; Q96M75; Q9H568" "" "" "0" "0" "1.046" "1.102" "1.084" "1.144" "1.099" "1.062" "1.076" "1.087" "0.666" "6747.4" "7056.0" "7435.3" "7316.4" "7720.4" "7415.8" "7164.1" "7258.4" "7335.8" "4491.8" "" "" "" "" "" "" "" "" "" "" "5983.4" "5844.8" "6487.6" "5471.7" "6437.8" "6812.2" "6054.8" "5999.5" "6728.0" "4491.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.000" "False" "237.501" "27" "32" "44" "32" "1393" "154.2" "7.88" "179.08" "32" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "1.027" "0.996" "1.068" "1.038" "1.027" "1.117" "1.105" "1.025" "1.104" "4491.1" "4611.6" "4472.6" "4797.2" "4662.3" "4613.6" "5015.9" "4962.9" "4602.2" "4958.5" "" "" "" "" "" "" "" "" "" "" "3982.6" "3820.0" "3902.5" "3587.7" "3887.7" "4238.1" "4239.2" "4102.2" "4220.8" "4958.5" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "237.099" "68" "15" "134" "9" "254" "28.8" "7.18" "527.59" "15" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "8" "6" "0.972" "0.993" "0.965" "0.976" "0.976" "0.921" "1.009" "0.988" "0.485" "16750.8" "16287.4" "16639.6" "16165.3" "16354.8" "16350.1" "15428.1" "16902.6" "16544.9" "8121.9" "" "" "" "" "" "" "" "" "" "" "14854.2" "13491.7" "14518.8" "12089.5" "13637.6" "15019.3" "13039.2" "13971.2" "15173.9" "8121.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "236.907" "59" "19" "104" "19" "371" "42.4" "5.35" "390.78" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Estrogen-dependent gene expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "11" "0" "1.053" "1.115" "1.038" "1.078" "1.063" "1.109" "1.119" "1.121" "0.612" "11111.3" "11704.2" "12392.8" "11537.3" "11980.8" "11807.6" "12320.9" "12438.2" "12460.3" "6801.9" "" "" "" "" "" "" "" "" "" "" "9853.3" "9695.1" "10813.3" "8628.4" "9990.3" "10846.6" "10413.1" "10281.0" "11427.8" "6801.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "236.592" "55" "39" "82" "39" "736" "81.8" "6.81" "285.40" "39" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Apoptotic execution phase" "Synaptic vesicle pathway; CAMKK2 pathway" "3" "0" "1.008" "1.030" "1.022" "1.034" "1.028" "1.236" "1.225" "1.199" "1.150" "4619.0" "4657.9" "4756.2" "4721.2" "4777.7" "4750.0" "5708.3" "5656.0" "5538.1" "5310.6" "" "" "" "" "" "" "" "" "" "" "4096.0" "3858.4" "4150.0" "3530.9" "3983.9" "4363.4" "4824.5" "4675.1" "5079.2" "5310.6" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "235.987" "67" "22" "66" "22" "434" "47.0" "5.44" "281.70" "22" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "" "6" "0" "0.974" "0.973" "0.873" "0.928" "0.921" "0.953" "0.940" "0.982" "0.584" "8737.8" "8513.6" "8504.5" "7624.0" "8107.7" "8043.3" "8328.7" "8211.6" "8581.9" "5101.8" "" "" "" "" "" "" "" "" "" "" "7748.5" "7052.3" "7420.6" "5701.7" "6760.8" "7388.7" "7039.1" "6787.5" "7870.8" "5101.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "235.433" "23" "41" "53" "41" "2039" "229.3" "6.96" "193.62" "41" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "0.964" "0.948" "0.969" "0.974" "0.990" "0.935" "0.938" "0.973" "0.573" "5313.2" "5123.0" "5038.5" "5150.1" "5173.5" "5258.1" "4968.0" "4983.9" "5167.5" "3041.8" "" "" "" "" "" "" "" "" "" "" "4711.6" "4243.6" "4396.3" "3851.6" "4314.0" "4830.2" "4198.7" "4119.6" "4739.3" "3041.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "234.634" "60" "20" "49" "20" "461" "49.9" "4.82" "227.96" "20" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "0.992" "0.992" "1.035" "1.005" "0.953" "1.055" "0.989" "0.918" "0.736" "6260.2" "6213.1" "6209.8" "6478.0" "6291.0" "5967.8" "6604.1" "6193.5" "5747.5" "4607.5" "" "" "" "" "" "" "" "" "" "" "5551.4" "5146.6" "5418.3" "4844.7" "5245.8" "5482.1" "5581.5" "5119.4" "5271.2" "4607.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "233.213" "63" "17" "84" "17" "308" "33.4" "5.69" "332.67" "17" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "Cytosolic sulfonation of small molecules" "" "1" "0" "1.000" "1.029" "1.046" "1.027" "1.003" "1.010" "1.043" "1.009" "0.470" "8698.5" "8696.9" "8948.8" "9095.5" "8931.8" "8728.8" "8786.2" "9074.5" "8778.4" "4090.7" "" "" "" "" "" "" "" "" "" "" "7713.7" "7204.1" "7808.3" "6802.2" "7447.9" "8018.4" "7425.7" "7500.7" "8051.0" "4090.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "232.691" "60" "25" "79" "23" "440" "49.2" "6.21" "294.29" "25" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "Antigen processing: Ubiquitination & Proteasome degradation; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "1" "1.005" "1.024" "1.087" "1.073" "1.052" "1.158" "1.129" "1.110" "0.772" "7460.8" "7496.9" "7639.3" "8110.8" "8007.3" "7849.2" "8640.8" "8421.8" "8282.3" "5756.3" "" "" "" "" "" "" "" "" "" "" "6616.1" "6210.1" "6665.7" "6065.8" "6677.0" "7210.3" "7302.8" "6961.2" "7596.0" "5756.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5876331061237715446" "False" "High" "IsMasterProtein" "Q14247" "Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2" "0.000" "False" "232.518" "50" "26" "65" "26" "550" "61.5" "5.40" "248.77" "26" "cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf02218, Pf14604" "2017" "ENSG00000085733; ENSG00000288401" "CTTN" "hsa:2017; Q14247; Q8N707; Q96H99" "Clathrin-mediated endocytosis; RHO GTPases activate PAKs" "Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP; HDAC6 interactions in the central nervous system" "6" "0" "0.948" "1.003" "0.928" "0.936" "1.008" "0.922" "1.011" "0.993" "0.481" "7256.0" "6875.6" "7277.9" "6737.1" "6792.9" "7310.8" "6690.8" "7337.0" "7206.4" "3490.6" "" "" "" "" "" "" "" "" "" "" "6434.5" "5695.4" "6350.3" "5038.4" "5664.4" "6715.8" "5654.8" "6064.5" "6609.2" "3490.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249429330709182822" "False" "High" "IsMasterProtein" "Cont_P68138" "Actin, alpha skeletal muscle OS=Bos taurus OX=9913 GN=ACTA1 PE=1 SV=1" "0.000" "True" "231.866" "36" "17" "568" "2" "377" "42.0" "5.39" "1880.53" "17" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100065454; 100154254; 100172818; 100395910; 100426612; 100542212; 100566789; 100609865; 100661558; 100716933; 100926492; 100955023; 100987270; 101018268; 101107662; 101316902; 101345310; 101371004; 101561057; 101607063; 101822895; 101878061; 101942538; 101972057; 102017886; 102121165; 102446120; 102836098; 102922102; 102943964; 103051164; 103127961; 103195041; 103624093; 103744113; 103818506; 104131026; 104291844; 104300855; 104488844; 104860683; 104987264; 105499142; 105505494; 105722343; 105823179; 105871143; 106543751; 106843698; 108498591; 108537854; 109248958; 109372851; 109689807; 11459; 281592; 29437; 58" "ENSABRG00000018240; ENSACAG00000001104; ENSACCG00020004955; ENSACDG00005004064; ENSACOG00000015573; ENSAMEG00000005186; ENSANAG00000033052; ENSANIG00000015411; ENSAOWG00000018027; ENSAPLG00000004146; ENSAPLG00020002125; ENSBGRG00000020862; ENSBIXG00000012362; ENSBIXG00005025901; ENSBMSG00010014761; ENSBTAG00000046332; ENSCABG00000013181; ENSCAFG00000008253; ENSCAFG00020027254; ENSCAFG00030012637; ENSCANG00000033017; ENSCCAG00000035682; ENSCCNG00000030664; ENSCGRG00001016859; ENSCJAG00000011114; ENSCLAG00000003307; ENSCMMG00000014710; ENSCMUG00000000473; ENSCPBG00000006129; ENSCPGG00000000824; ENSCPIG00010005220; ENSCPOG00000032187; ENSCPVG00000014620; ENSCSRG00000013784; ENSCUSG00005000547; ENSCWAG00000013028; ENSDLEG00000008382; ENSDNVG00000014331; ENSEASG00005031337; ENSEGOG00005009171; ENSFCAG00000030433; ENSFDAG00000018383; ENSFTIG00000004572; ENSG00000143632; ENSGAGG00000007922; ENSGEVG00005016044; ENSJHYG00000007552; ENSJJAG00000019369; ENSLAFG00000006306; ENSLCNG00005015654; ENSLLTG00000003642; ENSMCSG00000014926; ENSMFAG00000002280; ENSMGAG00000012010; ENSMICG00000007460; ENSMMNG00015014953; ENSMMSG00000010015; ENSMMUG00000022086; ENSMNEG00000003684; ENSMSIG00000009031; ENSMUNG00000016766; ENSMUSG00000031972; ENSNGAG00000008844; ENSNVIG00000023437; ENSOANG00000012845; ENSOARG00000003044; ENSOGAG00000016005; ENSOSUG00000015814; ENSPANG00000005524; ENSPCEG00000011384; ENSPCLG00000000773; ENSPCOG00000022008; ENSPCTG00005016061; ENSPEMG00000019882; ENSPLOG00000020512; ENSPMRG00000005431; ENSPPAG00000033916; ENSPPYG00000000127; ENSPSIG00000002854; ENSPSNG00000011648; ENSPSTG00000017705; ENSPTRG00000002086; ENSRBIG00000037124; ENSRFEG00010013727; ENSRNOG00000017786; ENSRNOG00055021900; ENSRNOG00060017592; ENSRNOG00065018197; ENSSCAG00000003577; ENSSHAG00000014035; ENSSHBG00005006730; ENSSMRG00000022024; ENSSOCG00000011564; ENSSSCG00000010190; ENSSSCG00015047339; ENSSSCG00040044916; ENSSSCG00055024685; ENSSSCG00065076746; ENSSSUG00005003524; ENSSTOG00000024222; ENSSVLG00005008349; ENSTGEG00000010273; ENSTGUG00000010041; ENSUAMG00000015031; ENSUPAG00010000311; ENSVKKG00000017431; ENSVURG00010000907; ENSVURG00010001203" "Acta1; ACTA1; LOC101345310; LOC101878061; LOC103127961; LOC103661861; LOC111160482; LOC112807841" "A0A090BWQ4; A0A091DQ28; A0A091EBT4; A0A091GSF2; A0A091GVU0; A0A091JKH4; A0A093GLM6; A0A096N2Y2; A0A098M1X6; A0A0A0AU99; A0A1S3APV3; A0A1U7QEW4; A0A1W7RJM3; A0A218VBM4; A0A226MSL5; A0A250XZP0; A0A2I0UAK3; A0A2J8M6H1; A0A2J8R810; A0A2K5EBS2; A0A2K5IRF2; A0A2K5S578; A0A2K5TYP0; A0A2K6ANM2; A0A2K6G1G8; A0A2K6LSJ0; A0A2P4SXB1; A0A2R9AZU8; A0A2U3W9D6; A0A2U4BVD6; A0A2Y9E0P7; A0A2Y9HE43; A0A2Y9L6W7; A0A2Y9LGX2; A0A2Y9S7L7; A0A3L7I1B1; A0A3L8S8G5; A0A3M0KHK7; A0A3Q7NT51; A0A452H615; A0A452RJE1; A0A480QNI6; A0A4U1EEU3; A0A4W2GZT5; A0A4X2JWN6; A0A5J5MT96; A0A5N3VLN8; A0A663E501; A0A667HAA9; A0A669PGX8; A0A670I895; A0A671F3Z0; A0A672U2N2; A0A673SW94; A0A6B2F569; A0A6B2F5D9; A0A6D2XHK8; A0A6I9M0F0; A0A6I9XXG7; A0A6J0HG37; A0A6J0T852; A0A6J1U9U4; A0A6J1YDW3; A0A6J2GP26; A0A6J2NA43; A0A6J3CTV5; A0A6J3EY96; A0A6P3ERW2; A0A6P3FJ88; A0A6P3HAS4; A0A6P5LDM6; A0A6P9CIM0; A0A6P9EZA5; A0A7J7EZ09; A0A7J7RJI6; A0A7J7RTV4; A0A7J8B841; A0A7J8BL15; A0A7K4JPE4; A0A7K4PSI7; A0A7K4QY10; A0A7K4RLR4; A0A7K4UDE9; A0A7K4UY42; A0A7K4W696; A0A7K4XA22; A0A7K4Y8W8; A0A7K4ZFF1; A0A7K5BDX3; A0A7K5D428; A0A7K5GNW3; A0A7K5HRK1; A0A7K5IK78; A0A7K5JXK4; A0A7K5KX43; A0A7K5MSI7; A0A7K5NP28; A0A7K5PKH5; A0A7K5QIU3; A0A7K5S142; A0A7K5SPK9; A0A7K5UC76; A0A7K5W8H5; A0A7K5XD37; A0A7K5Y7M0; A0A7K5ZW11; A0A7K6B2F8; A0A7K6BQV7; A0A7K6DCL1; A0A7K6EXZ1; A0A7K6FLR8; A0A7K6GNU4; A0A7K6HR31; A0A7K6J4T9; A0A7K6K4L6; A0A7K6LWQ9; A0A7K6M0L3; A0A7K6P948; A0A7K6RCV4; A0A7K6TEI2; A0A7K6VY88; A0A7K6XPH0; A0A7K6Z9M8; A0A7K6ZR93; A0A7K7AYM3; A0A7K7C659; A0A7K7DZL3; A0A7K7EWS4; A0A7K7G760; A0A7K7IH73; A0A7K7KDI8; A0A7K7KKJ6; A0A7K7MNF7; A0A7K7NEW8; A0A7K7PM04; A0A7K7QH90; A0A7K7RDG5; A0A7K7TAJ1; A0A7K7U609; A0A7K7XKX1; A0A7K8AQB9; A0A7K8BQL5; A0A7K8CRX7; A0A7K8EFR7; A0A7K8FRF9; A0A7K8GQ26; A0A7K8HWN9; A0A7K8ISA9; A0A7K8JPZ4; A0A7K8KS65; A0A7K8M0C5; A0A7K8N2Y9; A0A7K8PDY4; A0A7K8QME0; A0A7K8S6K4; A0A7K8T8U7; A0A7K8U5E0; A0A7K8VJC8; A0A7K8WMV3; A0A7K8Y2D4; A0A7K8YWW6; A0A7K8ZV32; A0A7K9AJ30; A0A7K9BS34; A0A7K9D6V1; A0A7K9EI05; A0A7K9FLR9; A0A7K9I701; A0A7K9IMC9; A0A7K9KC93; A0A7K9MVB8; A0A7K9NB46; A0A7K9PEG9; A0A7K9RST5; A0A7K9TK91; A0A7K9V843; A0A7K9W2K2; A0A7K9WX62; A0A7L0AFU5; A0A7L0BDS5; A0A7L0CIB3; A0A7L0EPL5; A0A7L0FCD1; A0A7L0G7Q5; A0A7L0HND8; A0A7L0II88; A0A7L0KT22; A0A7L0LSN2; A0A7L0NLS0; A0A7L0P7X4; A0A7L0RUG0; A0A7L0SJQ9; A0A7L0UGT7; A0A7L0XTP2; A0A7L0ZS39; A0A7L1B939; A0A7L1BT59; A0A7L1DMI6; A0A7L1DWR3; A0A7L1F253; A0A7L1GIR7; A0A7L1HPS8; A0A7L1IC62; A0A7L1K5Y1; A0A7L1L5V3; A0A7L1M7T5; A0A7L1NKU4; A0A7L1R8Z0; A0A7L1T000; A0A7L1U068; A0A7L1XCH6; A0A7L1YLD6; A0A7L2B7P4; A0A7L2BR48; A0A7L2CKL5; A0A7L2ESG9; A0A7L2FHP9; A0A7L2FY76; A0A7L2HHD4; A0A7L2IA74; A0A7L2JHG8; A0A7L2KMU3; A0A7L2LNS8; A0A7L2P8R5; A0A7L2QEC4; A0A7L2RU84; A0A7L2TB66; A0A7L2UV13; A0A7L2XQZ8; A0A7L2Z1X6; A0A7L2ZLP6; A0A7L3CN30; A0A7L3D9C1; A0A7L3GMY1; A0A7L3GYG9; A0A7L3ID24; A0A7L3IXN1; A0A7L3KUM5; A0A7L3LJJ7; A0A7L3M3X9; A0A7L3PPQ0; A0A7L3QHZ1; A0A7L3RH67; A0A7L3SGI7; A0A7L3U4P6; A0A7L3VNT2; A0A7L3WD55; A0A7L3Y1G6; A0A7L3YVD7; A0A7L3ZS54; A0A7L4AN29; A0A7L4CQM9; A0A7L4D5C7; A0A7L4DZI8; A0A7L4G527; A0A7L4GV55; A0A7L4IYY1; A0A7L4JN17; A0A7L4KJ61; A0A7L4MPA2; A0A7L4NEP2; A0A835NXC8; A0A850U7W3; A0A850V3D3; A0A850XEM6; A0A850Y843; A0A850ZDL2; A0A851BEY3; A0A851CN67; A0A851DTB7; A0A851EK28; A0A851FDE8; A0A851J837; A0A851KA41; A0A851LW39; A0A851NRY4; A0A851QJ25; A0A851RNA5; A0A851U848; A0A851VUC7; A0A851WKT2; A0A851XT74; A0A851YL06; A0A851ZBL2; A0A852BHA9; A0A852CRR6; A0A852D425; A0A852E1V9; A0A852F792; A0A852GJG7; A0A852IBF3; A0A852JDC5; A0A852JR42; A0A852KVX0; A0A852LXY4; A0A852NS61; A0A8B6ZNK4; A0A8B7GBR5; A0A8B7Q300; A0A8B8TZT0; A0A8B9CLG9; A0A8B9DEA1; A0A8B9GFW6; A0A8B9NJE6; A0A8B9QKT1; A0A8B9SHJ3; A0A8B9Y7Y7; A0A8C0DED2; A0A8C0H293; A0A8C0LYE1; A0A8C0N2I3; A0A8C2UWB6; A0A8C3CSU8; A0A8C3FFU4; A0A8C3L8M1; A0A8C3PH13; A0A8C3QCR3; A0A8C3SQW8; A0A8C3TNI9; A0A8C3WY11; A0A8C4PR70; A0A8C4U1I2; A0A8C4YAW6; A0A8C5IXG8; A0A8C5P2E0; A0A8C5RKR8; A0A8C5UFH7; A0A8C6FKL7; A0A8C6GS76; A0A8C6NGV1; A0A8C6QM24; A0A8C7BWL1; A0A8C8BUD5; A0A8C8S3P8; A0A8C8Y8T7; A0A8C9C427; A0A8C9LFS5; A0A8C9MJH4; A0A8D0E9T9; A0A8D0FGF9; A0A8D2B3M6; A0A8D2F0S7; A0A8D2GFE7; A0A8D2LUT0; A0A8J4MUQ6; A0A8J4N2X1; A0A8J4NK31; A0A8J4NVY9; A0A8J4PAG4; A0A8K0BNH4; A0A8K1LSE9; A0A8M1FCK6; A0A8P0NAG9; A0A8S9F5P5; A0A8U0V7M2; A0A9B0WSP0; A0A9F2KUS3; A0A9Q0Y593; A0A9V1E5M8; A0AA35K559; A0AA40L2Y5; A0AA41N2J4; acs:100566789; aful:116488210; aju:106984378; bbis:104987264; brhi:104488844; bta:281592; cang:105505494; cbrc:103624093; ccan:109689807; cfr:102507445; cjc:100395910; cmy:102943964; cpic:101942538; cpoc:100716933; cuca:104060336; cvf:104291844; dle:111163953; dpub:104300855; ecb:100065454; egz:104131026; elk:111160482; F7E1F2; F7FWZ0; F7HNV4; G1K932; G1LEZ5; G1NHJ8; G3SXX7; G3WM41; gga:421534; H0UXP6; H0XEG0; H0ZIF5; H2Q1A9; hai:109372851; hsa:58; I3N266; J3SBR4; K7F4I9; lav:100661558; M3XC93; M7AKZ6; maua:101822895; mcc:100426612; mcf:102121165; mgp:100542212; mmu:11459; mmur:105871143; mni:105499142; ngi:103744113; nss:113413315; nsu:110582311; oas:101107662; oga:100955023; oro:101371004; P02568; P68133; P68134; P68135; P68136; P68137; P68138; P68139; P99020; panu:101018268; pbi:103051164; pcad:102976743; pcoq:105823179; pcw:110217891; pdic:114512380; pgut:117672003; pon:100172818; pps:100987270; pss:102446120; ptr:100609865; pvt:110075363; Q3ZCG3; Q5R9Q5; Q5T8M9; rbb:108537854; rno:29437; scan:103818506; shr:100926492; ssc:100154254; T1E7F6; tmu:101345310; tsr:106543751; U3EUL6; U3I8T6; umr:103661861; V8NV61; W5NYJ1; zca:113923883" "Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction" "FAS pathway and stress induction of HSP regulation; Hypothetical network for drug addiction; Myometrial relaxation and contraction pathways; Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Striated muscle contraction; Myometrial relaxation and contraction pathways; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Burn wound healing; Pleural mesothelioma; Comprehensive IL-17A signaling; Striated muscle contraction" "22" "0" "1.115" "0.995" "0.984" "1.046" "1.082" "0.993" "1.077" "1.078" "0.537" "7821.0" "8724.1" "7784.7" "7697.9" "8178.6" "8461.5" "7767.9" "8423.8" "8431.7" "4201.8" "" "" "" "" "" "" "" "" "" "" "6935.5" "7226.6" "6792.5" "5757.0" "6819.8" "7772.9" "6565.1" "6962.9" "7733.0" "4201.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "231.285" "53" "22" "87" "21" "414" "46.6" "7.01" "310.79" "22" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "8" "1" "0.990" "1.013" "1.003" "1.022" "1.052" "1.015" "1.053" "1.021" "0.584" "11269.5" "11154.6" "11413.2" "11308.3" "11521.6" "11851.9" "11436.6" "11870.6" "11507.1" "6576.2" "" "" "" "" "" "" "" "" "" "" "9993.5" "9239.9" "9958.6" "8457.1" "9607.4" "10887.3" "9665.8" "9811.9" "10553.6" "6576.2" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "231.256" "26" "11" "74" "4" "589" "62.5" "5.11" "324.05" "11" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "1.067" "1.029" "1.094" "1.091" "1.018" "1.081" "1.022" "0.949" "0.619" "2218.4" "2366.5" "2283.6" "2426.6" "2419.3" "2259.1" "2397.0" "2268.2" "2106.0" "1372.1" "" "" "" "" "" "" "" "" "" "" "1967.3" "1960.3" "1992.6" "1814.8" "2017.4" "2075.2" "2025.9" "1874.8" "1931.5" "1372.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "231.195" "57" "22" "117" "22" "427" "45.2" "8.85" "414.18" "22" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "7" "0" "0.996" "1.037" "1.012" "1.016" "1.045" "0.991" "1.045" "1.016" "0.416" "13288.0" "13235.2" "13775.8" "13447.4" "13495.0" "13882.3" "13162.9" "13891.5" "13497.1" "5525.0" "" "" "" "" "" "" "" "" "" "" "11783.5" "10963.3" "12020.1" "10056.9" "11253.0" "12752.5" "11124.7" "11482.3" "12378.7" "5525.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "230.288" "45" "28" "57" "28" "676" "77.5" "7.75" "214.93" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Interferon gamma signaling; VEGFR2 mediated cell proliferation; Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "47" "0" "0.966" "0.998" "0.998" "1.055" "1.040" "1.092" "1.099" "1.052" "1.288" "4747.6" "4587.3" "4737.5" "4738.7" "5007.4" "4936.8" "5186.6" "5219.0" "4992.3" "6115.8" "" "" "" "" "" "" "" "" "" "" "4210.1" "3799.9" "4133.7" "3543.9" "4175.5" "4535.0" "4383.5" "4313.8" "4578.6" "6115.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "229.811" "57" "25" "70" "25" "491" "55.5" "7.15" "291.79" "25" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "9" "0" "1.028" "1.051" "1.009" "1.071" "1.079" "1.050" "1.102" "1.020" "0.482" "10327.8" "10615.8" "10851.1" "10424.0" "11060.6" "11148.6" "10843.6" "11381.5" "10532.3" "4973.0" "" "" "" "" "" "" "" "" "" "" "9158.5" "8793.6" "9468.1" "7795.8" "9223.0" "10241.3" "9164.5" "9407.6" "9659.5" "4973.0" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "229.594" "57" "19" "96" "19" "395" "43.6" "6.48" "400.63" "19" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Methylation" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "5" "0" "0.988" "1.031" "1.024" "1.016" "1.049" "0.983" "0.996" "0.972" "0.521" "10900.3" "10774.0" "11235.9" "11166.9" "11074.0" "11434.0" "10712.4" "10852.2" "10600.3" "5683.2" "" "" "" "" "" "" "" "" "" "" "9666.2" "8924.7" "9803.9" "8351.4" "9234.2" "10503.4" "9053.7" "8970.1" "9722.0" "5683.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "229.165" "42" "25" "77" "25" "637" "72.6" "6.29" "288.05" "25" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "5" "0" "1.050" "1.097" "1.051" "1.091" "1.102" "1.065" "1.097" "1.029" "0.555" "7513.8" "7891.1" "8243.3" "7896.7" "8197.1" "8280.4" "7999.3" "8239.9" "7732.8" "4172.9" "" "" "" "" "" "" "" "" "" "" "6663.1" "6536.6" "7192.7" "5905.6" "6835.3" "7606.5" "6760.7" "6810.8" "7092.0" "4172.9" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "229.067" "70" "24" "69" "24" "406" "46.2" "5.83" "279.26" "24" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle" "Ciliary landscape" "6" "0" "1.035" "1.060" "1.037" "1.051" "1.072" "1.034" "1.052" "1.038" "0.611" "5859.5" "6061.9" "6209.1" "6075.7" "6160.3" "6279.7" "6060.6" "6164.7" "6084.3" "3581.1" "" "" "" "" "" "" "" "" "" "" "5196.1" "5021.4" "5417.8" "4543.8" "5136.9" "5768.6" "5122.2" "5095.6" "5580.2" "3581.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "228.882" "53" "23" "262" "20" "332" "36.7" "8.27" "861.79" "23" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Pyruvate metabolism" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "20" "3" "1.025" "1.072" "1.011" "1.059" "1.022" "1.028" "1.063" "1.040" "0.494" "25032.8" "25653.8" "26840.9" "25315.6" "26516.8" "25572.0" "25721.8" "26601.1" "26041.3" "12358.3" "" "" "" "" "" "" "" "" "" "" "22198.6" "21250.3" "23420.0" "18932.7" "22111.4" "23490.7" "21739.0" "21987.7" "23883.4" "12358.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "228.803" "43" "20" "163" "18" "355" "38.4" "7.81" "644.72" "20" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "2" "0.963" "0.978" "0.956" "0.937" "0.952" "0.912" "0.969" "0.964" "0.501" "20805.4" "20045.6" "20344.4" "19881.0" "19488.0" "19802.1" "18970.8" "20152.2" "20046.2" "10416.1" "" "" "" "" "" "" "" "" "" "" "18449.8" "16604.8" "17751.5" "14868.3" "16250.4" "18190.4" "16033.4" "16657.2" "18385.1" "10416.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.000" "False" "228.644" "43" "25" "42" "25" "727" "79.4" "6.23" "183.90" "25" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "0.936" "0.917" "1.033" "0.986" "0.932" "1.128" "1.108" "0.981" "0.503" "5056.3" "4733.7" "4638.4" "5225.4" "4987.9" "4712.0" "5702.6" "5601.0" "4961.7" "2542.9" "" "" "" "" "" "" "" "" "" "" "4483.9" "3921.2" "4047.2" "3907.9" "4159.2" "4328.5" "4819.6" "4629.6" "4550.6" "2542.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "228.100" "10" "50" "56" "50" "5183" "573.5" "6.04" "195.35" "50" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "" "2" "0" "0.994" "0.943" "0.984" "0.960" "0.888" "1.058" "0.837" "1.039" "4.284" "2955.0" "2935.9" "2786.2" "2906.6" "2837.0" "2624.7" "3127.6" "2473.2" "3070.2" "12659.2" "" "" "" "" "" "" "" "" "" "" "2620.5" "2432.0" "2431.1" "2173.8" "2365.6" "2411.1" "2643.3" "2044.3" "2815.8" "12659.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8676466481375871245" "False" "High" "IsMasterProtein" "P08133" "Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3" "0.000" "False" "228.043" "59" "36" "62" "36" "673" "75.8" "5.60" "248.73" "36" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00191" "309" "ENSG00000197043" "ANXA6" "B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79" "Smooth Muscle Contraction" "Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation" "3" "0" "0.964" "0.890" "0.940" "0.911" "0.884" "0.972" "0.894" "0.945" "1.772" "6894.0" "6642.5" "6136.4" "6483.6" "6277.1" "6093.0" "6697.8" "6166.0" "6517.7" "12212.9" "" "" "" "" "" "" "" "" "" "" "6113.4" "5502.3" "5354.3" "4848.9" "5234.2" "5597.1" "5660.7" "5096.6" "5977.6" "12212.9" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "227.493" "37" "16" "60" "16" "520" "56.1" "7.46" "223.83" "16" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "" "2" "0" "0.984" "1.036" "0.999" "1.010" "0.991" "0.960" "1.025" "1.002" "0.509" "6832.0" "6720.8" "7077.6" "6827.9" "6902.7" "6770.5" "6560.9" "6999.6" "6848.8" "3478.1" "" "" "" "" "" "" "" "" "" "" "6058.4" "5567.1" "6175.5" "5106.4" "5755.9" "6219.4" "5545.0" "5785.7" "6281.3" "3478.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "227.456" "39" "28" "46" "28" "864" "94.2" "5.11" "196.82" "28" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "EGF/EGFR signaling pathway" "4" "0" "1.027" "1.011" "0.984" "0.989" "0.973" "0.828" "0.765" "0.810" "1.874" "4994.0" "5126.4" "5049.6" "4915.7" "4937.0" "4856.7" "4134.2" "3821.9" "4044.4" "9357.1" "" "" "" "" "" "" "" "" "" "" "4428.5" "4246.4" "4406.0" "3676.3" "4116.8" "4461.4" "3494.1" "3159.0" "3709.3" "9357.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "227.360" "64" "18" "58" "18" "390" "43.0" "5.26" "250.85" "18" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "Neutrophil degranulation; PKR-mediated signaling" "B cell receptor signaling pathway" "3" "0" "1.026" "1.065" "1.056" "1.075" "1.013" "1.023" "1.046" "0.950" "0.760" "6188.3" "6349.0" "6588.3" "6535.8" "6655.3" "6267.7" "6330.0" "6471.7" "5877.0" "4700.8" "" "" "" "" "" "" "" "" "" "" "5487.7" "5259.2" "5748.6" "4887.9" "5549.6" "5757.6" "5349.8" "5349.4" "5390.0" "4700.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2386724705728610253" "False" "High" "IsMasterProtein" "Q9UHB6" "LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1" "0.000" "False" "227.156" "46" "31" "65" "30" "759" "85.2" "6.84" "254.76" "31" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "51474" "ENSG00000050405" "LIMA1" "B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6" "" "" "0" "1" "0.948" "0.941" "0.957" "0.914" "0.952" "0.867" "0.948" "0.977" "0.422" "8402.4" "7968.1" "7906.3" "8045.2" "7677.3" "7995.2" "7281.6" "7966.3" "8212.4" "3548.9" "" "" "" "" "" "" "" "" "" "" "7451.0" "6600.4" "6898.6" "6016.7" "6401.8" "7344.5" "6154.1" "6584.7" "7531.9" "3548.9" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "226.952" "40" "24" "48" "24" "649" "71.4" "4.45" "208.74" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOD GTPase cycle; RHOH GTPase cycle" "5q35 copy number variation" "5" "0" "0.960" "0.972" "0.965" "0.957" "0.960" "1.011" "1.000" "0.975" "0.775" "4366.7" "4191.1" "4244.9" "4215.6" "4180.1" "4193.7" "4416.0" "4365.0" "4256.2" "3384.1" "" "" "" "" "" "" "" "" "" "" "3872.3" "3471.7" "3703.9" "3152.7" "3485.6" "3852.4" "3732.2" "3608.0" "3903.5" "3384.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "226.421" "47" "22" "95" "9" "407" "46.4" "5.48" "339.35" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Translation initiation complex formation; Ribosomal scanning and start codon recognition; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "11" "0" "0.997" "1.003" "0.992" "1.082" "1.072" "0.965" "1.017" "0.888" "0.510" "4122.9" "4112.1" "4137.2" "4090.8" "4462.5" "4419.4" "3980.0" "4191.5" "3661.5" "2104.2" "" "" "" "" "" "" "" "" "" "" "3656.1" "3406.3" "3609.9" "3059.3" "3721.1" "4059.7" "3363.7" "3464.6" "3358.1" "2104.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "226.410" "55" "25" "64" "25" "515" "59.2" "6.84" "255.53" "25" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "16" "0" "1.022" "1.034" "1.017" "1.065" "1.084" "1.086" "1.098" "1.070" "0.611" "7090.6" "7249.1" "7334.4" "7213.1" "7549.1" "7685.6" "7699.4" "7785.0" "7586.3" "4330.4" "" "" "" "" "" "" "" "" "" "" "6287.8" "6004.8" "6399.6" "5394.4" "6294.9" "7060.0" "6507.3" "6434.9" "6957.7" "4330.4" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "226.292" "16" "35" "55" "30" "2382" "250.6" "6.34" "191.91" "35" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Stimuli-sensing channels" "Ciliary landscape" "2" "3" "0.985" "0.973" "0.964" "0.963" "0.931" "0.950" "0.988" "0.991" "0.725" "5270.8" "5193.5" "5129.1" "5080.5" "5075.7" "4908.6" "5008.6" "5204.9" "5222.1" "3819.5" "" "" "" "" "" "" "" "" "" "" "4674.0" "4302.0" "4475.4" "3799.6" "4232.4" "4509.1" "4233.1" "4302.2" "4789.3" "3819.5" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "226.232" "41" "28" "43" "27" "873" "97.6" "4.60" "179.30" "28" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "1.031" "1.018" "1.057" "1.067" "1.037" "1.019" "1.032" "0.959" "0.578" "4820.7" "4967.8" "4909.4" "5096.6" "5144.4" "5001.0" "4911.1" "4977.2" "4621.4" "2787.9" "" "" "" "" "" "" "" "" "" "" "4274.9" "4115.1" "4283.7" "3811.6" "4289.7" "4594.0" "4150.6" "4114.0" "4238.5" "2787.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "225.972" "38" "31" "57" "28" "917" "102.4" "6.80" "213.76" "31" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "12" "3" "1.048" "1.015" "1.044" "1.081" "1.027" "1.035" "1.025" "0.972" "0.725" "5828.8" "6110.0" "5916.0" "6086.1" "6302.5" "5984.2" "6034.3" "5972.7" "5665.9" "4224.1" "" "" "" "" "" "" "" "" "" "" "5168.8" "5061.2" "5162.0" "4551.6" "5255.4" "5497.1" "5100.0" "4936.8" "5196.4" "4224.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "225.584" "44" "30" "81" "30" "714" "81.8" "5.67" "285.75" "30" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "7" "0" "1.057" "1.065" "1.035" "1.126" "1.001" "1.062" "1.026" "1.037" "0.586" "8369.4" "8843.8" "8911.3" "8658.2" "9420.8" "8377.7" "8892.1" "8590.0" "8681.3" "4901.8" "" "" "" "" "" "" "" "" "" "" "7421.8" "7325.7" "7775.6" "6475.2" "7855.7" "7695.8" "7515.2" "7100.3" "7961.9" "4901.8" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "224.813" "55" "29" "96" "29" "508" "57.1" "4.87" "326.48" "29" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; VLDL assembly; LDL remodeling; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "13" "0" "0.990" "1.020" "1.005" "1.015" "1.020" "1.043" "1.083" "1.072" "0.409" "13202.4" "13075.3" "13460.6" "13270.1" "13406.1" "13471.1" "13775.0" "14295.7" "14159.0" "5404.9" "" "" "" "" "" "" "" "" "" "" "11707.6" "10830.9" "11745.0" "9924.3" "11178.9" "12374.7" "11642.1" "11816.4" "12985.7" "5404.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "224.272" "37" "16" "73" "16" "528" "59.4" "4.41" "287.37" "16" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "" "7" "0" "0.978" "1.008" "0.971" "0.981" "0.945" "0.960" "1.009" "1.023" "0.479" "8887.0" "8695.0" "8962.5" "8627.3" "8718.6" "8396.7" "8534.0" "8967.1" "9094.2" "4252.8" "" "" "" "" "" "" "" "" "" "" "7880.9" "7202.5" "7820.2" "6452.1" "7270.2" "7713.3" "7212.6" "7411.9" "8340.7" "4252.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "224.026" "57" "17" "71" "15" "301" "33.9" "8.38" "261.56" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "15" "2" "0.985" "0.990" "1.005" "1.010" "0.969" "0.999" "0.981" "0.999" "0.720" "6582.8" "6487.2" "6519.2" "6614.5" "6646.2" "6378.8" "6577.6" "6458.5" "6577.3" "4740.3" "" "" "" "" "" "" "" "" "" "" "5837.5" "5373.7" "5688.4" "4946.8" "5542.0" "5859.6" "5559.1" "5338.4" "6032.3" "4740.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5810129024139572187" "False" "High" "IsMasterProtein" "P34931" "Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2" "0.000" "False" "223.194" "33" "20" "139" "2" "641" "70.3" "6.02" "523.24" "20" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3305" "ENSG00000204390; ENSG00000206383; ENSG00000234258; ENSG00000236251" "HSPA1L" "A6NNB0; B0UXW8; hsa:3305; O75634; P34931; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Attenuation phase" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection" "8" "0" "1.016" "1.019" "1.028" "0.859" "1.086" "0.992" "0.976" "0.949" "0.671" "558.8" "567.8" "569.2" "574.2" "480.0" "607.1" "554.3" "545.3" "530.1" "375.1" "" "" "" "" "" "" "" "" "" "" "495.5" "470.4" "496.7" "429.4" "400.3" "557.6" "468.5" "450.7" "486.1" "375.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "223.180" "61" "18" "44" "18" "397" "41.9" "8.09" "222.32" "18" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Mitochondrial Fatty Acid Beta-Oxidation" "Fatty acid biosynthesis" "2" "0" "1.002" "1.029" "0.976" "0.956" "0.982" "0.977" "1.010" "1.058" "0.385" "5706.5" "5718.5" "5870.8" "5568.0" "5455.3" "5605.4" "5578.1" "5764.8" "6039.2" "2194.8" "" "" "" "" "" "" "" "" "" "" "5060.4" "4736.9" "5122.6" "4164.1" "4549.0" "5149.2" "4714.4" "4765.0" "5538.8" "2194.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "222.876" "62" "27" "71" "27" "422" "47.4" "6.48" "256.57" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "63" "0" "0.988" "1.028" "0.978" "1.049" "0.999" "1.013" "1.082" "1.089" "0.749" "7505.9" "7414.8" "7713.8" "7343.9" "7874.3" "7499.9" "7606.0" "8124.5" "8176.3" "5619.3" "" "" "" "" "" "" "" "" "" "" "6656.1" "6142.1" "6730.6" "5492.3" "6566.1" "6889.5" "6428.3" "6715.5" "7498.8" "5619.3" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "222.402" "42" "24" "63" "24" "737" "82.5" "5.10" "277.55" "24" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "Neddylation; KEAP1-NFE2L2 pathway" "" "2" "0" "0.996" "0.963" "1.029" "1.002" "0.948" "1.170" "1.113" "1.050" "0.949" "5878.3" "5856.6" "5663.6" "6049.5" "5889.8" "5574.8" "6875.4" "6541.9" "6170.0" "5576.3" "" "" "" "" "" "" "" "" "" "" "5212.7" "4851.3" "4941.8" "4524.3" "4911.3" "5121.0" "5810.8" "5407.4" "5658.7" "5576.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "222.311" "42" "10" "65" "8" "391" "45.3" "4.46" "332.01" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "0" "1.010" "0.993" "1.023" "1.034" "1.047" "0.992" "0.984" "1.005" "1.170" "6659.6" "6723.0" "6610.1" "6811.6" "6889.3" "6972.5" "6603.1" "6554.0" "6689.9" "7794.0" "" "" "" "" "" "" "" "" "" "" "5905.6" "5569.0" "5767.6" "5094.1" "5744.7" "6405.0" "5580.7" "5417.3" "6135.6" "7794.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "222.127" "70" "20" "70" "20" "346" "38.4" "5.30" "286.15" "20" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "" "2" "0" "1.004" "1.009" "0.998" "0.951" "0.940" "0.933" "0.933" "0.871" "0.701" "9568.3" "9602.0" "9653.1" "9553.1" "9100.3" "8996.3" "8927.4" "8928.6" "8333.9" "6704.0" "" "" "" "" "" "" "" "" "" "" "8485.0" "7953.8" "8422.8" "7144.4" "7588.4" "8264.1" "7545.1" "7380.1" "7643.3" "6704.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "220.726" "51" "24" "62" "24" "538" "60.6" "8.03" "245.26" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "1.022" "0.985" "1.013" "1.009" "0.970" "0.944" "0.951" "0.896" "0.551" "6830.7" "6980.8" "6731.6" "6921.6" "6895.1" "6624.7" "6445.6" "6495.2" "6122.1" "3760.5" "" "" "" "" "" "" "" "" "" "" "6057.4" "5782.6" "5873.6" "5176.5" "5749.6" "6085.5" "5447.5" "5368.8" "5614.8" "3760.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "220.102" "50" "20" "58" "17" "411" "46.8" "6.73" "247.25" "20" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "TAR syndrome" "11" "0" "1.009" "1.008" "1.079" "1.094" "1.042" "1.057" "1.063" "0.922" "0.562" "4423.6" "4462.4" "4457.4" "4774.2" "4840.3" "4607.6" "4677.5" "4701.6" "4079.9" "2484.3" "" "" "" "" "" "" "" "" "" "" "3922.8" "3696.5" "3889.3" "3570.5" "4036.2" "4232.6" "3953.2" "3886.2" "3741.8" "2484.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "219.894" "60" "22" "48" "22" "370" "40.5" "5.10" "206.74" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "RHOH GTPase cycle" "Alstrom syndrome" "2" "0" "1.004" "1.030" "0.997" "0.984" "0.963" "1.042" "1.040" "1.069" "0.996" "4685.7" "4706.5" "4827.6" "4672.8" "4610.1" "4513.3" "4881.1" "4873.5" "5007.5" "4668.1" "" "" "" "" "" "" "" "" "" "" "4155.2" "3898.6" "4212.3" "3494.6" "3844.2" "4146.0" "4125.3" "4028.3" "4592.5" "4668.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "219.193" "62" "22" "71" "22" "376" "42.9" "5.81" "280.17" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "ER-Phagosome pathway; Neutrophil degranulation; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of expression of SLITs and ROBOs; UCH proteinases; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Asymmetric localization of PCP proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "1.011" "1.026" "1.101" "1.099" "1.040" "1.121" "1.098" "1.004" "0.754" "7512.0" "7595.9" "7710.1" "8274.2" "8258.4" "7814.4" "8419.0" "8246.4" "7542.5" "5664.8" "" "" "" "" "" "" "" "" "" "" "6661.5" "6292.0" "6727.4" "6188.0" "6886.4" "7178.4" "7115.4" "6816.2" "6917.5" "5664.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "219.073" "51" "14" "135" "14" "324" "35.9" "9.88" "578.13" "14" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; Noncanonical activation of NOTCH3" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "10" "0" "1.004" "1.012" "1.007" "1.007" "1.012" "0.952" "1.010" "1.027" "0.617" "9910.8" "9947.6" "10031.5" "9982.9" "9980.3" "10032.2" "9433.6" "10013.3" "10182.2" "6112.7" "" "" "" "" "" "" "" "" "" "" "8788.7" "8240.1" "8753.0" "7465.9" "8322.2" "9215.7" "7972.9" "8276.7" "9338.5" "6112.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "218.956" "35" "25" "67" "25" "786" "87.9" "7.99" "250.54" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "Mitochondrial RNA degradation" "" "1" "0" "1.004" "0.991" "0.986" "1.044" "1.019" "1.018" "1.043" "0.990" "0.628" "7304.6" "7335.6" "7237.5" "7201.9" "7628.8" "7442.0" "7435.5" "7617.7" "7229.7" "4590.1" "" "" "" "" "" "" "" "" "" "" "6477.6" "6076.4" "6315.1" "5386.1" "6361.4" "6836.3" "6284.2" "6296.6" "6630.6" "4590.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "218.794" "40" "28" "57" "28" "838" "90.3" "5.05" "212.61" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus" "4p16.3 copy number variation" "3" "0" "0.973" "0.950" "0.968" "0.939" "0.939" "0.941" "0.950" "0.982" "0.635" "3884.7" "3778.0" "3691.4" "3758.7" "3646.9" "3649.2" "3656.5" "3691.5" "3815.8" "2468.4" "" "" "" "" "" "" "" "" "" "" "3444.8" "3129.5" "3220.9" "2811.0" "3041.0" "3352.2" "3090.3" "3051.3" "3499.6" "2468.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "218.439" "50" "27" "67" "26" "553" "59.7" "9.13" "255.93" "27" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "7" "1" "0.949" "0.939" "0.995" "0.974" "0.978" "0.903" "0.931" "0.848" "0.466" "9095.4" "8628.7" "8538.4" "9050.8" "8860.9" "8895.2" "8214.4" "8464.2" "7709.4" "4234.4" "" "" "" "" "" "" "" "" "" "" "8065.6" "7147.6" "7450.2" "6768.8" "7388.8" "8171.2" "6942.5" "6996.2" "7070.6" "4234.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "218.279" "64" "16" "56" "16" "324" "36.7" "6.06" "219.27" "16" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "Platelet degranulation" "" "1" "0" "0.984" "1.002" "0.962" "0.965" "0.967" "0.935" "1.001" "1.000" "0.499" "6353.0" "6248.4" "6362.8" "6113.8" "6128.3" "6141.0" "5938.2" "6362.2" "6350.8" "3168.7" "" "" "" "" "" "" "" "" "" "" "5633.7" "5175.8" "5551.9" "4572.3" "5110.2" "5641.2" "5018.7" "5258.8" "5824.6" "3168.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "218.155" "50" "26" "90" "26" "562" "61.4" "6.76" "326.55" "26" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "13" "0" "1.023" "1.009" "1.042" "1.061" "1.052" "1.032" "1.066" "0.970" "0.502" "11446.8" "11713.2" "11549.3" "11922.9" "12145.6" "12046.6" "11818.7" "12197.6" "11101.5" "5750.1" "" "" "" "" "" "" "" "" "" "" "10150.8" "9702.6" "10077.3" "8916.8" "10127.8" "11066.1" "9988.7" "10082.2" "10181.6" "5750.1" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "218.099" "33" "31" "54" "31" "971" "110.3" "5.77" "207.11" "31" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "1.000" "0.983" "0.944" "0.917" "0.889" "1.019" "0.717" "0.942" "6.286" "4368.8" "4367.6" "4294.9" "4122.4" "4006.8" "3882.0" "4452.8" "3131.5" "4116.4" "27464.7" "" "" "" "" "" "" "" "" "" "" "3874.2" "3617.9" "3747.5" "3083.0" "3341.2" "3566.1" "3763.4" "2588.4" "3775.3" "27464.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "217.981" "43" "21" "64" "21" "558" "61.4" "7.80" "242.06" "21" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "9" "0" "1.031" "1.061" "1.045" "1.086" "1.077" "1.073" "1.118" "1.067" "0.463" "6978.6" "7194.2" "7401.4" "7295.5" "7579.3" "7516.4" "7484.7" "7804.7" "7444.7" "3228.2" "" "" "" "" "" "" "" "" "" "" "6188.5" "5959.3" "6458.1" "5456.1" "6320.1" "6904.7" "6325.8" "6451.1" "6827.8" "3228.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "217.874" "49" "21" "47" "21" "499" "56.8" "6.28" "202.02" "21" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "MAPK signaling pathway; ATM signaling in development and disease" "5" "0" "0.958" "1.004" "0.923" "0.941" "0.993" "0.991" "0.985" "1.006" "0.896" "6106.8" "5849.5" "6131.9" "5636.8" "5748.0" "6063.4" "6049.5" "6012.8" "6143.6" "5472.8" "" "" "" "" "" "" "" "" "" "" "5415.4" "4845.4" "5350.3" "4215.6" "4793.1" "5569.9" "5112.8" "4970.0" "5634.6" "5472.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4840156573364048016" "False" "High" "IsMasterProtein" "Q58FF7" "Putative heat shock protein HSP 90-beta-3 OS=Homo sapiens OX=9606 GN=HSP90AB3P PE=5 SV=1" "0.000" "False" "217.815" "28" "22" "196" "1" "597" "68.3" "4.79" "598.11" "22" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00183" "" "" "HSP90AB3P" "Q58FF7" "" "" "0" "0" "0.927" "0.973" "1.005" "0.998" "0.910" "1.006" "0.920" "0.982" "2.784" "239.5" "222.0" "233.0" "240.6" "238.9" "218.0" "240.9" "220.2" "235.1" "666.7" "" "" "" "" "" "" "" "" "" "" "212.3" "183.9" "203.3" "179.9" "199.2" "200.3" "203.6" "182.0" "215.6" "666.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "217.502" "54" "30" "55" "21" "573" "65.3" "6.20" "212.60" "30" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "MHC class II antigen presentation; Signaling by ALK fusions and activated point mutants; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "8" "7" "0.973" "1.015" "0.936" "0.946" "1.013" "1.056" "1.057" "1.054" "0.952" "7215.4" "7023.3" "7323.9" "6753.8" "6827.8" "7305.9" "7621.9" "7625.2" "7607.9" "6871.3" "" "" "" "" "" "" "" "" "" "" "6398.5" "5817.8" "6390.5" "5051.0" "5693.4" "6711.3" "6441.7" "6302.8" "6977.5" "6871.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "216.183" "38" "23" "79" "23" "599" "67.3" "8.34" "292.70" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "OAS antiviral response; Interferon alpha/beta signaling" "" "2" "0" "1.014" "1.040" "1.025" "1.038" "1.040" "1.041" "1.046" "1.005" "0.472" "7983.7" "8091.6" "8303.1" "8184.9" "8283.2" "8303.5" "8307.7" "8348.9" "8026.9" "3771.7" "" "" "" "" "" "" "" "" "" "" "7079.7" "6702.7" "7244.8" "6121.2" "6907.0" "7627.7" "7021.3" "6901.0" "7361.7" "3771.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "215.943" "24" "31" "50" "31" "1475" "153.8" "8.73" "189.62" "31" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "TGF-beta signaling pathway" "29" "0" "0.977" "0.989" "0.924" "0.936" "0.971" "0.862" "0.922" "0.939" "0.517" "6617.5" "6463.8" "6547.6" "6112.6" "6195.6" "6423.9" "5707.5" "6101.3" "6215.9" "3423.3" "" "" "" "" "" "" "" "" "" "" "5868.3" "5354.3" "5713.1" "4571.4" "5166.3" "5901.1" "4823.7" "5043.2" "5700.9" "3423.3" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "215.684" "80" "16" "70" "16" "241" "26.9" "5.17" "319.03" "16" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.017" "1.051" "1.038" "1.004" "1.030" "1.012" "1.026" "0.976" "0.686" "9671.4" "9838.2" "10167.9" "10038.8" "9711.0" "9964.4" "9785.5" "9918.1" "9437.8" "6635.1" "" "" "" "" "" "" "" "" "" "" "8576.4" "8149.5" "8872.0" "7507.7" "8097.7" "9153.4" "8270.3" "8198.0" "8655.7" "6635.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "215.607" "60" "14" "73" "14" "328" "35.6" "7.39" "326.01" "14" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "1.008" "0.995" "1.102" "1.062" "0.991" "1.037" "1.066" "0.984" "0.524" "9471.7" "9546.5" "9420.5" "10437.5" "10058.3" "9382.5" "9826.2" "10097.2" "9321.0" "4966.5" "" "" "" "" "" "" "" "" "" "" "8399.3" "7907.8" "8219.9" "7805.9" "8387.2" "8618.8" "8304.7" "8346.0" "8548.7" "4966.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "214.715" "33" "31" "50" "14" "949" "104.5" "5.06" "201.94" "31" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "13" "1.034" "1.021" "1.071" "1.084" "1.040" "1.052" "1.040" "0.960" "1.219" "3530.8" "3649.8" "3605.0" "3782.2" "3828.2" "3671.8" "3715.7" "3671.2" "3391.0" "4302.3" "" "" "" "" "" "" "" "" "" "" "3131.0" "3023.3" "3145.5" "2828.6" "3192.2" "3373.0" "3140.4" "3034.5" "3110.0" "4302.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "214.505" "41" "27" "50" "27" "760" "84.8" "6.61" "198.70" "27" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; RHOH GTPase cycle" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "21" "0" "1.029" "0.976" "0.924" "0.966" "1.039" "0.985" "1.004" "1.104" "0.913" "5526.5" "5687.8" "5395.1" "5107.2" "5340.8" "5740.2" "5441.9" "5548.9" "6099.4" "5046.6" "" "" "" "" "" "" "" "" "" "" "4900.8" "4711.5" "4707.5" "3819.5" "4453.5" "5273.0" "4599.3" "4586.6" "5594.0" "5046.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1567690974661695744" "False" "High" "IsMasterProtein" "Q9NY65" "Tubulin alpha-8 chain OS=Homo sapiens OX=9606 GN=TUBA8 PE=1 SV=1" "0.000" "False" "214.435" "33" "13" "178" "1" "449" "50.1" "5.06" "716.00" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "51807" "ENSG00000183785" "TUBA8" "B2RCX2; B3KPW9; B4DWG3; hsa:51807; Q2M3N4; Q9NY65" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; PKR-mediated signaling; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; HCMV Early Events; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Recycling pathway of L1; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "32" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "214.222" "48" "21" "85" "19" "456" "52.9" "7.65" "287.20" "21" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "2" "1.076" "1.039" "1.095" "1.142" "1.061" "1.159" "1.133" "1.088" "0.783" "8101.9" "8719.6" "8415.8" "8872.0" "9255.5" "8597.7" "9392.1" "9182.1" "8816.5" "6340.0" "" "" "" "" "" "" "" "" "" "" "7184.6" "7222.9" "7343.2" "6635.0" "7717.8" "7897.9" "7937.8" "7589.6" "8085.9" "6340.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "214.125" "21" "34" "48" "34" "2089" "226.5" "5.47" "191.34" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of DNA damage response and repair proteins; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "9" "0" "0.980" "0.935" "0.944" "0.924" "0.899" "0.840" "0.810" "0.801" "0.514" "5215.6" "5113.4" "4877.3" "4922.4" "4820.6" "4687.5" "4380.5" "4227.1" "4177.9" "2682.7" "" "" "" "" "" "" "" "" "" "" "4625.0" "4235.7" "4255.7" "3681.3" "4019.7" "4305.9" "3702.2" "3494.0" "3831.7" "2682.7" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "213.231" "75" "18" "87" "17" "240" "26.8" "4.73" "337.65" "18" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "XBP1(S) activates chaperone genes" "IL-18 signaling pathway" "2" "0" "0.943" "0.927" "0.863" "0.871" "0.867" "0.830" "0.926" "0.968" "0.561" "12552.3" "11841.1" "11641.5" "10829.7" "10931.4" "10885.0" "10416.8" "11624.9" "12155.4" "7044.1" "" "" "" "" "" "" "" "" "" "" "11131.2" "9808.6" "10157.8" "8099.2" "9115.3" "9999.1" "8803.9" "9608.8" "11148.2" "7044.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2475503787040523239" "False" "High" "IsMasterProtein" "Q9UM54" "Unconventional myosin-VI OS=Homo sapiens OX=9606 GN=MYO6 PE=1 SV=4" "0.000" "False" "213.138" "30" "35" "44" "35" "1294" "149.6" "8.53" "172.83" "35" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf16521, Pf21521" "4646" "ENSG00000196586" "MYO6" "A6H8V4; E1P540; hsa:4646; Q5TEM5; Q5TEM6; Q5TEM7; Q9BZZ7; Q9UEG2; Q9UM54" "RHOU GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Trafficking of AMPA receptors; Gap junction degradation" "VEGFA-VEGFR2 signaling; Joubert syndrome" "7" "0" "0.988" "1.006" "1.084" "1.080" "1.086" "1.371" "1.317" "1.253" "0.954" "4155.7" "4104.8" "4181.6" "4506.0" "4489.4" "4513.6" "5697.4" "5473.9" "5208.0" "3963.9" "" "" "" "" "" "" "" "" "" "" "3685.2" "3400.2" "3648.7" "3369.9" "3743.5" "4146.3" "4815.2" "4524.6" "4776.4" "3963.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "212.126" "48" "22" "71" "22" "472" "51.1" "8.40" "276.63" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "14" "0" "1.018" "1.098" "1.038" "1.054" "1.027" "1.060" "1.055" "1.034" "0.545" "9648.4" "9825.6" "10590.5" "10010.4" "10164.8" "9909.9" "10225.0" "10183.6" "9978.6" "5255.2" "" "" "" "" "" "" "" "" "" "" "8556.0" "8139.0" "9240.7" "7486.4" "8476.1" "9103.3" "8641.8" "8417.5" "9151.7" "5255.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "211.920" "37" "27" "61" "27" "835" "88.5" "5.77" "237.74" "27" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "HCMV Early Events; SUMOylation of transcription cofactors; Generic Transcription Pathway" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "6" "0" "1.064" "1.011" "1.003" "0.981" "0.988" "0.980" "0.704" "0.988" "5.238" "3770.6" "4012.8" "3813.0" "3782.8" "3699.5" "3724.9" "3694.5" "2653.2" "3724.7" "19750.0" "" "" "" "" "" "" "" "" "" "" "3343.7" "3324.0" "3327.0" "2829.0" "3084.9" "3421.7" "3122.4" "2193.1" "3416.1" "19750.0" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "211.909" "40" "24" "62" "24" "609" "69.8" "6.64" "244.32" "24" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "9" "0" "1.021" "0.979" "0.983" "0.991" "0.980" "0.991" "0.686" "0.939" "6.089" "4901.7" "5006.8" "4796.9" "4816.8" "4856.9" "4802.2" "4856.4" "3360.9" "4603.4" "29845.7" "" "" "" "" "" "" "" "" "" "" "4346.7" "4147.4" "4185.5" "3602.3" "4050.0" "4411.3" "4104.4" "2778.0" "4221.9" "29845.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "211.739" "47" "21" "55" "21" "606" "66.2" "6.65" "254.59" "21" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Platelet degranulation" "Hypertrophy model" "2" "0" "0.984" "1.063" "0.958" "0.992" "1.028" "0.911" "0.976" "0.945" "0.639" "7218.0" "7105.1" "7674.8" "6913.4" "7157.4" "7420.8" "6575.1" "7046.1" "6822.9" "4610.6" "" "" "" "" "" "" "" "" "" "" "6400.8" "5885.5" "6696.6" "5170.3" "5968.3" "6816.8" "5557.0" "5824.1" "6257.5" "4610.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "211.733" "23" "36" "48" "36" "1843" "211.2" "6.90" "185.46" "36" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "" "52" "0" "0.940" "0.916" "1.035" "0.980" "0.883" "1.132" "1.080" "1.010" "1.277" "3267.8" "3072.2" "2992.8" "3381.9" "3203.5" "2884.6" "3698.1" "3528.0" "3299.4" "4172.8" "" "" "" "" "" "" "" "" "" "" "2897.9" "2544.9" "2611.3" "2529.2" "2671.3" "2649.9" "3125.5" "2916.1" "3026.0" "4172.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "211.283" "62" "21" "93" "20" "331" "38.2" "5.38" "340.84" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; RND2 GTPase cycle; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; PAFAH1B1 copy number variation" "9" "1" "0.931" "0.932" "0.921" "0.887" "0.909" "0.994" "0.974" "0.994" "0.817" "16451.0" "15320.7" "15339.4" "15145.2" "14589.4" "14960.6" "16346.5" "16023.7" "16360.0" "13443.7" "" "" "" "" "" "" "" "" "" "" "14588.4" "12690.9" "13384.4" "11326.6" "12165.5" "13743.0" "13815.4" "13244.7" "15004.4" "13443.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "210.872" "43" "21" "69" "21" "474" "53.3" "7.34" "256.52" "21" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "3" "0" "0.995" "0.993" "0.977" "0.963" "0.990" "0.925" "0.980" "0.972" "0.596" "7600.4" "7558.6" "7546.2" "7423.4" "7316.3" "7527.6" "7032.6" "7447.5" "7390.3" "4528.3" "" "" "" "" "" "" "" "" "" "" "6739.8" "6261.1" "6584.4" "5551.7" "6100.8" "6914.9" "5943.7" "6155.9" "6778.0" "4528.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "210.636" "43" "33" "56" "26" "729" "80.2" "8.27" "210.61" "33" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "SUMOylation of transcription cofactors" "Novel intracellular components of RIG-I-like receptor pathway" "2" "5" "1.001" "1.032" "0.915" "0.928" "1.026" "0.780" "0.730" "0.849" "2.120" "4294.9" "4297.7" "4433.7" "3930.6" "3984.2" "4405.4" "3351.9" "3134.1" "3647.9" "9105.3" "" "" "" "" "" "" "" "" "" "" "3808.6" "3560.0" "3868.6" "2939.6" "3322.3" "4046.9" "2832.9" "2590.6" "3345.7" "9105.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "209.565" "39" "26" "62" "18" "780" "85.0" "7.50" "235.85" "26" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Neutrophil degranulation; Glycolysis" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "9" "0" "1.040" "1.026" "1.051" "1.023" "0.958" "0.986" "1.008" "1.009" "0.596" "3151.9" "3277.8" "3235.4" "3312.5" "3224.7" "3021.0" "3106.6" "3176.9" "3180.4" "1877.5" "" "" "" "" "" "" "" "" "" "" "2795.0" "2715.1" "2823.1" "2477.3" "2688.9" "2775.2" "2625.5" "2625.9" "2916.9" "1877.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "209.492" "26" "32" "43" "32" "1576" "171.4" "8.09" "180.15" "32" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "1.030" "1.008" "1.107" "1.080" "1.050" "1.029" "1.017" "0.914" "0.580" "4095.3" "4219.1" "4128.3" "4534.3" "4422.6" "4298.5" "4215.6" "4164.0" "3742.5" "2373.5" "" "" "" "" "" "" "" "" "" "" "3631.6" "3494.9" "3602.2" "3391.1" "3687.9" "3948.7" "3562.9" "3441.9" "3432.4" "2373.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "209.121" "61" "12" "150" "12" "210" "23.3" "5.64" "667.28" "12" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "11" "0" "1.022" "1.033" "1.035" "1.032" "1.050" "1.012" "1.053" "0.984" "0.574" "16339.2" "16699.2" "16874.5" "16916.5" "16861.8" "17163.9" "16534.3" "17209.0" "16086.0" "9378.0" "" "" "" "" "" "" "" "" "" "" "14489.3" "13832.8" "14723.8" "12651.3" "14060.5" "15767.0" "13974.2" "14224.5" "14753.0" "9378.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "208.869" "37" "29" "57" "29" "795" "87.2" "7.12" "207.92" "29" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Mitochondrial protein degradation" "Amino acid metabolism" "2" "0" "1.037" "1.031" "1.047" "1.007" "0.935" "1.273" "1.233" "1.193" "1.013" "4689.7" "4864.5" "4836.3" "4909.1" "4721.8" "4382.7" "5969.8" "5781.7" "5593.8" "4750.4" "" "" "" "" "" "" "" "" "" "" "4158.8" "4029.5" "4219.9" "3671.4" "3937.4" "4026.0" "5045.4" "4779.0" "5130.3" "4750.4" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "208.582" "46" "29" "73" "29" "693" "76.7" "6.87" "264.35" "29" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "" "2" "0" "0.939" "0.939" "0.998" "0.973" "0.925" "1.143" "1.136" "1.075" "1.507" "7707.6" "7236.5" "7237.5" "7691.0" "7502.5" "7128.2" "8812.8" "8754.6" "8287.1" "11614.3" "" "" "" "" "" "" "" "" "" "" "6834.9" "5994.3" "6315.0" "5751.8" "6256.0" "6548.0" "7448.2" "7236.3" "7600.4" "11614.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5364611794781451874" "False" "High" "IsMasterProtein" "P08575" "Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3" "0.000" "False" "208.111" "25" "31" "61" "31" "1306" "147.4" "6.15" "235.61" "31" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00041, Pf00102, Pf12453, Pf12567" "5788" "ENSG00000081237; ENSG00000262418" "PTPRC" "A0A0A0MT22; A8K7W6; hsa:5788; P08575; Q16614; Q9H0Y6; X6R433" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Other semaphorin interactions" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulatory circuits of the STAT3 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; EPO receptor signaling; Interferon type I signaling pathways" "9" "0" "1.020" "1.027" "1.020" "1.049" "1.038" "1.045" "1.013" "1.204" "0.574" "6574.7" "6706.4" "6753.2" "6705.0" "6899.1" "6825.8" "6871.7" "6660.1" "7919.1" "3774.2" "" "" "" "" "" "" "" "" "" "" "5830.3" "5555.3" "5892.5" "5014.4" "5752.9" "6270.3" "5807.7" "5505.0" "7262.9" "3774.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "207.239" "52" "25" "54" "24" "418" "47.3" "5.21" "219.55" "25" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Assembly of the pre-replicative complex; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "64" "1" "1.013" "1.042" "1.069" "1.098" "1.089" "1.154" "1.179" "1.132" "0.614" "4950.7" "5015.8" "5160.8" "5292.8" "5437.1" "5393.0" "5711.8" "5836.4" "5606.3" "3038.7" "" "" "" "" "" "" "" "" "" "" "4390.2" "4154.9" "4503.0" "3958.3" "4533.8" "4954.1" "4827.4" "4824.2" "5141.8" "3038.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "206.771" "42" "25" "71" "25" "597" "68.0" "6.35" "261.27" "25" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "3" "0" "0.948" "0.989" "1.058" "1.095" "1.113" "1.377" "1.337" "1.331" "1.111" "5476.5" "5190.1" "5413.8" "5792.2" "5998.3" "6095.4" "7538.6" "7323.2" "7287.3" "6084.3" "" "" "" "" "" "" "" "" "" "" "4856.4" "4299.2" "4723.8" "4331.8" "5001.8" "5599.3" "6371.3" "6053.1" "6683.5" "6084.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "206.553" "44" "12" "110" "12" "294" "32.6" "4.78" "466.55" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "" "10" "0" "0.984" "0.938" "1.008" "0.966" "0.842" "0.983" "0.919" "0.923" "0.520" "12472.4" "12274.6" "11695.4" "12571.8" "12045.4" "10504.3" "12264.1" "11463.3" "11516.6" "6486.1" "" "" "" "" "" "" "" "" "" "" "11060.2" "10167.7" "10204.8" "9402.0" "10044.2" "9649.4" "10365.2" "9475.2" "10562.3" "6486.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "206.332" "36" "27" "80" "27" "796" "91.6" "5.49" "310.89" "27" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "WNT ligand biogenesis and trafficking" "" "1" "0" "1.018" "1.002" "1.086" "1.077" "1.010" "1.082" "1.055" "0.923" "0.672" "9196.7" "9366.3" "9211.4" "9986.8" "9903.4" "9292.4" "9947.2" "9701.4" "8489.6" "6179.9" "" "" "" "" "" "" "" "" "" "" "8155.4" "7758.6" "8037.4" "7468.8" "8258.1" "8536.1" "8407.0" "8018.9" "7786.2" "6179.9" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "205.367" "58" "23" "101" "23" "430" "47.5" "9.01" "354.38" "23" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "11" "0" "1.020" "1.047" "1.009" "1.017" "1.053" "1.007" "1.009" "0.985" "0.394" "12958.1" "13211.0" "13568.7" "13071.0" "13182.5" "13638.5" "13042.9" "13071.2" "12757.7" "5110.6" "" "" "" "" "" "" "" "" "" "" "11491.0" "10943.4" "11839.4" "9775.4" "10992.4" "12528.5" "11023.4" "10804.3" "11700.6" "5110.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "205.045" "54" "23" "53" "23" "476" "54.8" "6.61" "215.56" "23" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "mRNA processing; 15q25 copy number variation" "5" "0" "0.983" "1.005" "1.011" "0.983" "0.947" "0.901" "1.050" "0.969" "0.507" "8074.6" "7939.6" "8112.8" "8163.6" "7933.6" "7643.9" "7271.6" "8480.2" "7821.5" "4091.4" "" "" "" "" "" "" "" "" "" "" "7160.4" "6576.8" "7078.8" "6105.3" "6615.6" "7021.8" "6145.7" "7009.5" "7173.4" "4091.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9204758010535676815" "False" "High" "IsMasterProtein" "Q641Q2" "WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3" "0.000" "False" "204.751" "27" "27" "38" "6" "1341" "147.1" "4.81" "171.09" "27" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "387680" "ENSG00000099290" "WASHC2A" "A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0" "" "" "0" "15" "0.966" "0.977" "0.969" "0.928" "0.901" "0.936" "0.957" "0.969" "0.962" "5174.9" "4998.6" "5056.0" "5012.6" "4800.0" "4661.6" "4841.9" "4951.6" "5012.4" "4978.6" "" "" "" "" "" "" "" "" "" "" "4589.0" "4140.6" "4411.6" "3748.8" "4002.6" "4282.2" "4092.1" "4092.9" "4597.1" "4978.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "204.664" "29" "33" "42" "33" "1288" "147.1" "6.79" "174.52" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Ciliary landscape" "3" "0" "0.990" "0.941" "0.997" "0.946" "0.961" "0.977" "0.519" "1.008" "8.892" "1969.4" "1950.6" "1852.7" "1964.1" "1863.7" "1891.8" "1925.0" "1021.7" "1984.3" "17512.5" "" "" "" "" "" "" "" "" "" "" "1746.4" "1615.8" "1616.6" "1468.9" "1554.0" "1737.8" "1626.9" "844.5" "1819.9" "17512.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "203.867" "49" "31" "53" "31" "723" "83.4" "6.67" "192.28" "31" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "Cytosolic tRNA aminoacylation" "" "1" "0" "0.931" "0.926" "0.945" "0.914" "0.864" "1.078" "0.983" "0.984" "1.847" "5621.9" "5231.4" "5206.9" "5310.0" "5137.2" "4855.8" "6059.3" "5526.3" "5529.9" "10381.7" "" "" "" "" "" "" "" "" "" "" "4985.4" "4333.4" "4543.2" "3971.2" "4283.7" "4460.6" "5121.1" "4567.9" "5071.7" "10381.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "203.450" "40" "27" "42" "27" "896" "98.6" "4.64" "172.50" "27" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "8" "0" "1.035" "1.014" "0.973" "0.985" "0.944" "0.923" "0.852" "0.935" "2.418" "3238.6" "3353.5" "3283.2" "3152.7" "3189.3" "3056.2" "2987.8" "2760.0" "3029.5" "7832.2" "" "" "" "" "" "" "" "" "" "" "2871.9" "2777.8" "2864.7" "2357.8" "2659.5" "2807.5" "2525.1" "2281.3" "2778.4" "7832.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "202.574" "53" "21" "54" "16" "447" "51.7" "6.20" "230.86" "21" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "7" "5" "0.988" "1.031" "0.973" "1.009" "1.061" "0.990" "1.022" "0.991" "0.537" "6293.6" "6220.6" "6487.9" "6126.0" "6348.7" "6676.0" "6228.8" "6434.5" "6235.6" "3377.2" "" "" "" "" "" "" "" "" "" "" "5581.0" "5152.8" "5661.0" "4581.4" "5293.9" "6132.7" "5264.3" "5318.6" "5718.9" "3377.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "202.508" "30" "29" "52" "12" "937" "104.5" "5.38" "210.06" "29" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD4; Recycling pathway of L1; Retrograde neurotrophin signalling; Potential therapeutics for SARS; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "20" "0" "1.028" "1.120" "0.974" "1.082" "1.106" "1.071" "1.068" "1.096" "0.976" "2297.7" "2361.0" "2574.4" "2237.0" "2486.7" "2540.3" "2460.7" "2454.8" "2517.5" "2242.7" "" "" "" "" "" "" "" "" "" "" "2037.5" "1955.7" "2246.3" "1673.0" "2073.6" "2333.5" "2079.7" "2029.1" "2308.9" "2242.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "202.457" "65" "16" "228" "6" "246" "28.1" "4.83" "798.73" "16" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "33" "0" "1.033" "0.974" "0.949" "0.958" "1.085" "0.926" "0.995" "1.019" "0.543" "8690.5" "8978.3" "8462.7" "8247.2" "8329.6" "9432.2" "8050.9" "8643.6" "8853.3" "4720.7" "" "" "" "" "" "" "" "" "" "" "7706.6" "7437.2" "7384.1" "6167.8" "6945.7" "8664.6" "6804.3" "7144.5" "8119.7" "4720.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "202.175" "44" "18" "70" "18" "524" "59.0" "7.34" "276.34" "18" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "1.164" "1.006" "1.057" "1.070" "1.088" "1.104" "1.099" "1.025" "0.576" "7562.8" "8804.7" "7604.6" "7994.5" "8089.9" "8225.3" "8348.1" "8310.6" "7755.1" "4353.3" "" "" "" "" "" "" "" "" "" "" "6706.5" "7293.4" "6635.4" "5978.8" "6745.9" "7555.9" "7055.5" "6869.3" "7112.5" "4353.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "201.418" "46" "26" "39" "23" "584" "58.8" "5.21" "170.55" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "Formation of the cornified envelope" "" "2" "4" "0.945" "1.318" "1.687" "0.857" "4.733" "0.860" "1.404" "1.406" "1.464" "2959.8" "2797.1" "3900.5" "4992.3" "2537.1" "14008.8" "2545.9" "4155.1" "4160.4" "4332.9" "" "" "" "" "" "" "" "" "" "" "2624.7" "2317.0" "3403.4" "3733.6" "2115.6" "12868.6" "2151.7" "3434.5" "3815.7" "4332.9" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "201.416" "45" "17" "77" "17" "455" "52.5" "6.27" "297.24" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.001" "0.987" "0.997" "1.001" "1.011" "1.017" "1.022" "0.953" "0.467" "9411.6" "9420.3" "9287.0" "9380.4" "9423.1" "9518.4" "9567.0" "9614.0" "8972.8" "4397.0" "" "" "" "" "" "" "" "" "" "" "8346.0" "7803.3" "8103.4" "7015.3" "7857.6" "8743.8" "8085.7" "7946.7" "8229.3" "4397.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "201.335" "40" "19" "73" "19" "494" "53.8" "5.87" "251.53" "19" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "Carnitine synthesis" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "4" "0" "1.019" "1.033" "1.051" "1.045" "1.049" "1.040" "1.070" "1.014" "0.458" "8373.8" "8535.3" "8648.9" "8799.1" "8747.5" "8783.7" "8712.9" "8956.5" "8491.6" "3837.2" "" "" "" "" "" "" "" "" "" "" "7425.8" "7070.2" "7546.6" "6580.6" "7294.2" "8068.8" "7363.8" "7403.2" "7788.0" "3837.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "200.819" "52" "24" "40" "24" "583" "66.7" "5.11" "167.44" "24" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "1.006" "1.016" "0.976" "0.988" "0.927" "0.981" "0.987" "0.932" "0.810" "5794.7" "5828.1" "5890.1" "5657.8" "5722.4" "5371.1" "5684.1" "5721.8" "5399.4" "4692.0" "" "" "" "" "" "" "" "" "" "" "5138.6" "4827.7" "5139.4" "4231.3" "4771.7" "4934.0" "4804.0" "4729.4" "4952.0" "4692.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "200.246" "24" "28" "39" "28" "1332" "150.2" "5.94" "151.82" "28" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HATs acetylate histones" "HDAC6 interactions in the central nervous system" "2" "0" "1.171" "0.990" "1.081" "1.030" "1.016" "1.051" "1.012" "0.929" "1.217" "3685.1" "4314.7" "3649.4" "3983.3" "3795.9" "3745.9" "3873.7" "3730.0" "3424.8" "4484.0" "" "" "" "" "" "" "" "" "" "" "3267.9" "3574.0" "3184.3" "2979.0" "3165.3" "3441.0" "3273.9" "3083.1" "3141.0" "4484.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "199.832" "32" "38" "53" "38" "1265" "147.8" "6.64" "189.19" "38" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "30" "0" "1.087" "1.023" "1.125" "1.094" "1.070" "1.055" "0.286" "1.110" "19.793" "1886.4" "2051.5" "1930.0" "2121.4" "2064.5" "2018.0" "1990.6" "539.4" "2094.3" "37336.7" "" "" "" "" "" "" "" "" "" "" "1672.8" "1699.3" "1684.0" "1586.6" "1721.5" "1853.8" "1682.3" "445.9" "1920.7" "37336.7" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "199.572" "57" "16" "49" "16" "350" "38.4" "5.12" "202.52" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "Downregulation of TGF-beta receptor signaling" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "3" "0" "0.973" "0.996" "0.948" "0.984" "1.036" "0.987" "1.010" "0.973" "1.010" "6762.4" "6579.0" "6733.1" "6410.6" "6657.0" "7003.3" "6677.5" "6826.9" "6577.5" "6831.1" "" "" "" "" "" "" "" "" "" "" "5996.7" "5449.7" "5874.9" "4794.3" "5551.0" "6433.3" "5643.6" "5642.9" "6032.4" "6831.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "199.170" "42" "20" "108" "19" "486" "54.0" "4.81" "425.56" "20" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "3" "1" "0.951" "0.994" "0.885" "0.940" "0.980" "0.921" "1.013" "0.994" "0.496" "12109.5" "11519.1" "12039.3" "10712.1" "11386.6" "11873.1" "11151.1" "12262.0" "12031.2" "6007.4" "" "" "" "" "" "" "" "" "" "" "10738.5" "9541.8" "10504.8" "8011.2" "9494.9" "10906.8" "9424.5" "10135.4" "11034.3" "6007.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "199.126" "41" "20" "52" "19" "649" "70.9" "7.39" "184.34" "20" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "Detoxification of Reactive Oxygen Species; PPARA activates gene expression; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "16" "1" "1.047" "1.173" "1.162" "1.204" "1.258" "1.246" "1.287" "1.299" "0.815" "5562.6" "5822.4" "6524.3" "6462.1" "6695.9" "6996.0" "6929.8" "7160.4" "7223.5" "4535.2" "" "" "" "" "" "" "" "" "" "" "4932.8" "4823.0" "5692.8" "4832.8" "5583.5" "6426.6" "5856.8" "5918.6" "6624.9" "4535.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "198.996" "42" "19" "43" "19" "536" "61.5" "9.52" "181.49" "19" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "16" "0" "0.960" "1.037" "0.947" "0.967" "0.997" "0.920" "0.991" "0.995" "0.687" "5417.5" "5198.5" "5619.8" "5128.2" "5239.1" "5398.6" "4986.0" "5369.3" "5389.5" "3719.5" "" "" "" "" "" "" "" "" "" "" "4804.1" "4306.2" "4903.6" "3835.2" "4368.7" "4959.2" "4214.0" "4438.1" "4942.9" "3719.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "198.723" "33" "24" "52" "24" "793" "88.8" "5.22" "200.40" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.917" "0.926" "0.906" "0.876" "0.911" "0.923" "0.875" "0.911" "1.629" "5373.9" "4928.3" "4975.6" "4866.3" "4706.7" "4894.0" "4961.3" "4702.1" "4894.9" "8753.1" "" "" "" "" "" "" "" "" "" "" "4765.5" "4082.4" "4341.4" "3639.3" "3924.7" "4495.7" "4193.1" "3886.6" "4489.3" "8753.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "197.891" "54" "26" "70" "26" "514" "58.7" "6.43" "260.87" "26" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "Selenocysteine synthesis; Cytosolic tRNA aminoacylation" "VEGFA-VEGFR2 signaling" "3" "0" "1.027" "1.047" "1.076" "1.086" "1.091" "1.104" "1.147" "1.072" "0.599" "5967.6" "6127.3" "6249.0" "6419.2" "6480.8" "6513.1" "6586.4" "6844.9" "6399.5" "3574.0" "" "" "" "" "" "" "" "" "" "" "5292.0" "5075.6" "5452.6" "4800.7" "5404.1" "5983.0" "5566.6" "5657.8" "5869.2" "3574.0" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "197.627" "31" "40" "61" "22" "1278" "148.3" "7.31" "201.60" "40" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "Fragile X syndrome; Regulation of actin cytoskeleton" "7" "16" "0.996" "0.990" "0.998" "0.982" "0.976" "0.993" "1.009" "0.886" "0.744" "6095.3" "6070.4" "6033.6" "6086.0" "5984.1" "5949.7" "6054.0" "6149.5" "5398.6" "4533.9" "" "" "" "" "" "" "" "" "" "" "5405.2" "5028.4" "5264.6" "4551.5" "4989.9" "5465.4" "5116.6" "5083.0" "4951.3" "4533.9" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "High" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.000" "False" "197.566" "20" "45" "60" "45" "2335" "273.4" "8.84" "197.99" "45" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.032" "0.989" "1.057" "0.996" "0.992" "1.058" "0.963" "0.976" "1.964" "4516.1" "4660.3" "4466.0" "4771.6" "4496.6" "4482.2" "4780.2" "4349.6" "4408.4" "8868.4" "" "" "" "" "" "" "" "" "" "" "4004.8" "3860.4" "3896.8" "3568.5" "3749.5" "4117.4" "4040.1" "3595.3" "4043.1" "8868.4" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "197.131" "33" "28" "51" "28" "1010" "107.7" "6.70" "210.20" "28" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Purine ribonucleoside monophosphate biosynthesis" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "4" "0" "1.060" "0.987" "1.087" "1.048" "1.030" "1.011" "0.988" "1.025" "1.983" "4167.8" "4419.9" "4113.1" "4530.7" "4369.4" "4293.2" "4213.0" "4116.7" "4270.3" "8263.9" "" "" "" "" "" "" "" "" "" "" "3695.9" "3661.3" "3588.9" "3388.4" "3643.5" "3943.8" "3560.7" "3402.7" "3916.5" "8263.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "196.765" "61" "16" "57" "9" "356" "37.5" "7.09" "232.24" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "Ferroptosis" "3" "9" "1.142" "1.060" "1.132" "1.097" "1.016" "1.069" "0.945" "1.005" "2.914" "4945.5" "5646.8" "5240.8" "5596.6" "5423.3" "5022.5" "5288.1" "4672.7" "4970.7" "14410.6" "" "" "" "" "" "" "" "" "" "" "4385.6" "4677.5" "4572.8" "4185.5" "4522.3" "4613.7" "4469.3" "3862.3" "4558.8" "14410.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "196.520" "43" "29" "119" "29" "611" "69.1" "5.73" "419.08" "29" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "16" "0" "0.984" "0.979" "0.965" "0.943" "0.952" "0.889" "0.939" "0.950" "0.398" "9518.4" "9365.9" "9316.7" "9184.4" "8974.8" "9062.9" "8462.1" "8934.6" "9046.1" "3788.2" "" "" "" "" "" "" "" "" "" "" "8440.7" "7758.3" "8129.2" "6868.7" "7483.8" "8325.2" "7151.8" "7385.1" "8296.5" "3788.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2327422208095163378" "False" "High" "IsMasterProtein" "P35749" "Myosin-11 OS=Homo sapiens OX=9606 GN=MYH11 PE=1 SV=3" "0.000" "False" "196.512" "9" "22" "64" "1" "1972" "227.2" "5.50" "258.69" "22" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4629" "ENSG00000133392; ENSG00000276480" "MYH11" "D2JYH7; hsa:4629; O00396; O94944; P35749; P78422; Q3MIV8; Q3MNF0; Q3MNF1" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "VEGFA-VEGFR2 signaling" "8" "0" "0.335" "0.264" "0.217" "0.275" "0.246" "0.239" "0.251" "0.277" "0.570" "405.1" "135.6" "106.8" "88.1" "111.6" "99.5" "96.9" "101.6" "112.4" "230.9" "" "" "" "" "" "" "" "" "" "" "359.3" "112.3" "93.2" "65.9" "93.0" "91.4" "81.9" "83.9" "103.1" "230.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "196.415" "41" "17" "58" "17" "509" "54.1" "7.85" "235.27" "17" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "19" "0" "0.983" "0.958" "0.982" "0.927" "0.941" "0.940" "0.967" "0.930" "0.366" "8631.5" "8488.8" "8266.8" "8480.4" "7999.9" "8123.6" "8117.7" "8349.5" "8024.0" "3157.4" "" "" "" "" "" "" "" "" "" "" "7654.2" "7031.7" "7213.2" "6342.2" "6670.9" "7462.4" "6860.8" "6901.4" "7359.1" "3157.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "196.215" "43" "18" "49" "18" "511" "56.5" "5.81" "197.15" "18" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "" "5" "0" "1.079" "1.050" "1.062" "1.061" "1.065" "1.050" "1.070" "0.961" "0.680" "4645.3" "5014.6" "4876.8" "4935.2" "4929.5" "4948.2" "4877.9" "4968.7" "4466.0" "3157.8" "" "" "" "" "" "" "" "" "" "" "4119.4" "4153.8" "4255.2" "3690.9" "4110.5" "4545.5" "4122.6" "4107.0" "4096.0" "3157.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "196.088" "56" "18" "64" "18" "334" "37.5" "7.36" "229.93" "18" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Ub-specific processing proteases; Methylation" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "8" "0" "0.960" "0.973" "1.040" "1.008" "1.025" "0.989" "1.007" "0.936" "0.576" "6800.7" "6526.5" "6620.0" "7069.4" "6856.2" "6971.2" "6722.6" "6848.1" "6368.2" "3919.8" "" "" "" "" "" "" "" "" "" "" "6030.7" "5406.2" "5776.3" "5287.0" "5717.1" "6403.9" "5681.6" "5660.5" "5840.5" "3919.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "195.806" "30" "29" "67" "29" "928" "106.1" "7.94" "248.01" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "51" "0" "1.003" "1.001" "1.034" "1.021" "1.003" "1.096" "1.106" "1.031" "0.736" "7618.8" "7643.8" "7623.8" "7875.3" "7779.5" "7640.1" "8350.0" "8427.0" "7856.7" "5611.1" "" "" "" "" "" "" "" "" "" "" "6756.2" "6331.8" "6652.1" "5889.7" "6487.1" "7018.3" "7057.1" "6965.5" "7205.7" "5611.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "195.484" "50" "22" "69" "22" "505" "55.2" "7.23" "245.28" "22" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "tRNA processing in the nucleus" "Unfolded protein response" "2" "0" "0.996" "1.018" "0.991" "0.992" "0.999" "1.035" "1.073" "1.030" "0.671" "7965.6" "7930.8" "8111.6" "7894.0" "7898.0" "7959.6" "8246.0" "8548.2" "8201.5" "5346.9" "" "" "" "" "" "" "" "" "" "" "7063.7" "6569.5" "7077.8" "5903.7" "6585.9" "7311.8" "6969.2" "7065.7" "7521.9" "5346.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "195.325" "66" "19" "54" "17" "327" "38.1" "6.57" "200.29" "19" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "WNT ligand biogenesis and trafficking" "" "1" "2" "1.062" "1.057" "1.032" "1.065" "1.092" "1.127" "1.165" "1.007" "0.689" "4190.3" "4451.4" "4427.7" "4323.7" "4464.8" "4577.3" "4721.3" "4883.6" "4219.4" "2885.0" "" "" "" "" "" "" "" "" "" "" "3715.9" "3687.4" "3863.4" "3233.5" "3723.0" "4204.7" "3990.3" "4036.6" "3869.7" "2885.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "194.653" "42" "16" "73" "16" "484" "54.9" "7.11" "271.76" "16" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "1.012" "1.021" "0.998" "1.024" "1.035" "0.962" "1.021" "0.975" "0.490" "8209.7" "8304.3" "8379.5" "8193.1" "8408.5" "8493.9" "7894.7" "8383.8" "8001.8" "4025.9" "" "" "" "" "" "" "" "" "" "" "7280.2" "6878.9" "7311.5" "6127.3" "7011.5" "7802.6" "6672.3" "6929.8" "7338.8" "4025.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "194.216" "56" "21" "77" "21" "396" "44.7" "7.81" "267.01" "21" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "Platelet degranulation" "" "1" "0" "1.019" "1.040" "0.993" "1.038" "1.063" "1.058" "1.144" "1.116" "0.683" "9554.9" "9733.1" "9940.1" "9484.9" "9916.9" "10159.7" "10109.8" "10927.3" "10663.7" "6529.1" "" "" "" "" "" "" "" "" "" "" "8473.1" "8062.4" "8673.3" "7093.5" "8269.4" "9332.8" "8544.4" "9032.2" "9780.1" "6529.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "194.202" "51" "17" "54" "17" "423" "47.8" "6.65" "204.00" "17" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "6" "0" "1.028" "1.057" "1.017" "1.082" "1.044" "1.023" "1.056" "1.060" "0.576" "6594.2" "6780.0" "6971.6" "6707.6" "7136.2" "6886.2" "6746.9" "6966.0" "6991.8" "3800.1" "" "" "" "" "" "" "" "" "" "" "5847.6" "5616.2" "6083.1" "5016.4" "5950.6" "6325.7" "5702.2" "5757.9" "6412.4" "3800.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "193.997" "49" "32" "65" "24" "509" "57.4" "5.88" "223.26" "32" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Cytosolic tRNA aminoacylation" "Allograft rejection" "2" "7" "1.007" "1.110" "1.177" "1.163" "1.125" "1.470" "1.411" "1.376" "0.776" "5827.2" "5869.8" "6468.0" "6855.9" "6774.2" "6556.4" "8565.6" "8222.6" "8020.6" "4522.1" "" "" "" "" "" "" "" "" "" "" "5167.4" "4862.3" "5643.6" "5127.3" "5648.8" "6022.7" "7239.3" "6796.6" "7356.0" "4522.1" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397536938893978881" "False" "High" "IsMasterProtein" "O43491" "Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1" "0.000" "False" "193.793" "34" "29" "38" "28" "1005" "112.5" "5.44" "153.23" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2037" "ENSG00000079819" "EPB41L2" "B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2" "Neurexins and neuroligins" "Splicing factor NOVA regulated synaptic proteins" "2" "1" "1.033" "1.016" "1.019" "1.001" "1.049" "0.998" "1.043" "0.999" "0.667" "3943.4" "4071.9" "4004.7" "4018.9" "3948.4" "4138.5" "3933.6" "4112.5" "3941.2" "2631.2" "" "" "" "" "" "" "" "" "" "" "3496.9" "3372.9" "3494.3" "3005.6" "3292.4" "3801.7" "3324.5" "3399.3" "3614.6" "2631.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "193.194" "26" "28" "74" "27" "1075" "113.3" "8.59" "283.25" "28" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "" "16p11.2 distal deletion syndrome" "1" "1" "0.990" "0.997" "0.935" "0.947" "0.944" "0.897" "0.927" "0.936" "0.813" "9242.3" "9148.4" "9210.3" "8636.9" "8753.8" "8721.5" "8287.5" "8563.4" "8651.7" "7513.6" "" "" "" "" "" "" "" "" "" "" "8195.9" "7578.1" "8036.4" "6459.3" "7299.5" "8011.7" "7004.2" "7078.2" "7934.8" "7513.6" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "192.372" "61" "14" "52" "2" "309" "35.6" "5.54" "226.59" "14" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "Cyclin A/B1/B2 associated events during G2/M transition; DARPP-32 events; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "53" "0" "0.986" "0.955" "0.963" "0.941" "1.065" "1.001" "0.993" "0.940" "0.458" "2149.1" "2119.6" "2053.3" "2069.9" "2023.1" "2288.1" "2150.6" "2134.7" "2019.9" "984.6" "" "" "" "" "" "" "" "" "" "" "1905.7" "1755.8" "1791.6" "1548.0" "1687.0" "2101.9" "1817.6" "1764.5" "1852.5" "984.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "191.988" "61" "14" "46" "2" "309" "35.6" "5.43" "205.40" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Separation of Sister Chromatids; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "45" "14" "1.053" "1.075" "1.050" "1.087" "1.127" "1.071" "1.063" "1.041" "0.598" "5794.4" "6103.5" "6226.4" "6083.0" "6300.7" "6528.0" "6207.5" "6160.3" "6030.7" "3463.8" "" "" "" "" "" "" "" "" "" "" "5138.4" "5055.8" "5432.8" "4549.3" "5254.0" "5996.7" "5246.3" "5092.0" "5531.0" "3463.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "191.723" "70" "11" "121" "6" "152" "17.1" "6.19" "475.51" "11" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "Pyrimidine metabolism" "4" "0" "0.999" "1.020" "0.958" "1.045" "1.022" "1.024" "1.063" "0.985" "0.523" "8655.9" "8644.6" "8829.9" "8296.2" "9044.0" "8850.6" "8861.4" "9197.8" "8525.1" "4530.8" "" "" "" "" "" "" "" "" "" "" "7675.9" "7160.7" "7704.5" "6204.5" "7541.4" "8130.3" "7489.3" "7602.6" "7818.7" "4530.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "191.331" "32" "27" "42" "27" "1023" "115.9" "6.86" "167.41" "27" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "0.917" "0.946" "1.017" "0.967" "0.928" "1.107" "1.028" "0.971" "1.385" "5447.9" "4996.0" "5153.5" "5541.4" "5270.0" "5053.3" "6029.6" "5601.7" "5290.7" "7545.1" "" "" "" "" "" "" "" "" "" "" "4831.1" "4138.4" "4496.6" "4144.2" "4394.5" "4642.0" "5096.0" "4630.2" "4852.3" "7545.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "191.225" "55" "15" "74" "15" "332" "37.5" "7.87" "330.10" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "0.922" "0.920" "0.901" "0.899" "0.881" "0.918" "0.973" "0.964" "0.704" "14573.9" "13442.9" "13402.9" "13136.5" "13096.7" "12845.3" "13379.5" "14177.7" "14044.4" "10260.2" "" "" "" "" "" "" "" "" "" "" "12923.9" "11135.4" "11694.6" "9824.4" "10920.9" "11799.8" "11307.8" "11718.9" "12880.7" "10260.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "191.106" "16" "36" "52" "36" "2752" "299.4" "12.06" "206.93" "36" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "mRNA Splicing - Major Pathway" "" "1" "0" "0.984" "0.937" "0.892" "0.897" "0.851" "0.798" "0.838" "0.890" "0.916" "6314.6" "6213.2" "5919.1" "5632.7" "5661.5" "5373.3" "5039.9" "5291.6" "5617.4" "5785.4" "" "" "" "" "" "" "" "" "" "" "5599.7" "5146.7" "5164.7" "4212.5" "4721.0" "4936.0" "4259.5" "4373.9" "5151.9" "5785.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "170444545631699205" "False" "High" "IsMasterProtein" "Q9Y4E1" "WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5" "0.000" "False" "190.875" "23" "24" "36" "3" "1341" "147.1" "4.81" "156.35" "24" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "253725" "ENSG00000172661" "WASHC2C" "A0A096LPC5; B4DZQ6; B9EK53; F5H0J6; F5H871; hsa:253725; Q5SQU4; Q5SQU5; Q7L521; Q9UG79; Q9Y4E1" "" "" "0" "0" "1.175" "1.130" "1.183" "1.106" "0.909" "1.180" "0.891" "1.101" "1.250" "52.8" "62.1" "59.7" "62.5" "58.5" "48.0" "62.3" "47.1" "58.2" "66.0" "" "" "" "" "" "" "" "" "" "" "46.9" "51.4" "52.1" "46.8" "48.7" "44.1" "52.7" "38.9" "53.4" "66.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "190.648" "55" "18" "48" "18" "360" "41.5" "4.91" "187.66" "18" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "" "2q37 copy number variation syndrome" "1" "0" "1.000" "0.975" "1.010" "1.021" "0.989" "0.989" "0.967" "0.969" "0.815" "3725.4" "3724.6" "3633.4" "3764.0" "3803.1" "3684.4" "3685.6" "3604.1" "3611.0" "3037.7" "" "" "" "" "" "" "" "" "" "" "3303.6" "3085.3" "3170.3" "2815.0" "3171.2" "3384.5" "3114.9" "2979.1" "3311.8" "3037.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "190.587" "60" "20" "65" "20" "410" "46.6" "7.37" "291.78" "20" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "AURKA Activation by TPX2; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "18" "0" "1.022" "1.045" "1.056" "1.082" "1.038" "1.076" "1.092" "0.987" "0.650" "6623.0" "6767.8" "6923.5" "6994.0" "7167.8" "6875.8" "7126.2" "7230.2" "6538.3" "4302.0" "" "" "" "" "" "" "" "" "" "" "5873.2" "5606.1" "6041.1" "5230.5" "5977.0" "6316.2" "6022.8" "5976.3" "5996.5" "4302.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "190.266" "74" "11" "177" "8" "140" "15.0" "8.27" "607.48" "11" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "9" "5" "1.010" "1.090" "0.984" "1.038" "1.063" "1.088" "1.086" "1.178" "0.656" "14840.2" "14994.4" "16170.5" "14603.1" "15397.7" "15777.4" "16153.3" "16110.9" "17487.6" "9739.0" "" "" "" "" "" "" "" "" "" "" "13160.0" "12420.7" "14109.6" "10921.2" "12839.6" "14493.3" "13652.1" "13316.8" "16038.6" "9739.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "190.111" "34" "17" "47" "17" "638" "71.4" "5.20" "191.43" "17" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "HCMV Early Events; MHC class II antigen presentation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "23" "0" "0.961" "1.031" "1.001" "1.008" "0.913" "1.038" "1.121" "1.085" "0.889" "4373.3" "4200.8" "4510.2" "4379.5" "4407.2" "3991.5" "4538.5" "4903.9" "4744.1" "3886.9" "" "" "" "" "" "" "" "" "" "" "3878.1" "3479.7" "3935.4" "3275.3" "3675.0" "3666.7" "3835.7" "4053.4" "4351.0" "3886.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "190.042" "70" "18" "84" "18" "263" "29.5" "6.61" "290.34" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "ER-Phagosome pathway; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; UCH proteinases; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.040" "1.044" "1.058" "1.045" "1.023" "1.034" "1.028" "0.989" "0.542" "8137.2" "8459.6" "8498.7" "8607.4" "8506.1" "8322.7" "8415.3" "8365.4" "8047.1" "4406.9" "" "" "" "" "" "" "" "" "" "" "7215.9" "7007.5" "7415.5" "6437.2" "7092.9" "7645.3" "7112.3" "6914.6" "7380.3" "4406.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "189.966" "43" "27" "53" "27" "722" "79.2" "6.80" "199.57" "27" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "Sialylation" "3" "0" "0.992" "1.037" "1.066" "1.039" "0.983" "1.038" "1.063" "1.014" "0.529" "5095.0" "5052.3" "5285.8" "5432.4" "5292.0" "5007.8" "5288.0" "5414.9" "5164.5" "2693.4" "" "" "" "" "" "" "" "" "" "" "4518.1" "4185.1" "4612.1" "4062.7" "4412.8" "4600.3" "4469.2" "4475.8" "4736.6" "2693.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "189.848" "39" "26" "54" "26" "732" "82.7" "5.81" "196.76" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "9" "0" "1.088" "1.001" "1.028" "1.035" "0.937" "1.042" "0.608" "0.958" "8.264" "3176.3" "3454.7" "3180.4" "3266.8" "3288.8" "2976.7" "3308.9" "1929.9" "3041.5" "26248.5" "" "" "" "" "" "" "" "" "" "" "2816.7" "2861.7" "2775.1" "2443.1" "2742.4" "2734.5" "2796.6" "1595.2" "2789.5" "26248.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "189.599" "45" "16" "61" "16" "456" "50.1" "6.55" "247.77" "16" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "1.081" "1.063" "1.087" "1.097" "1.087" "1.033" "1.087" "1.013" "0.555" "4967.5" "5367.5" "5281.7" "5397.3" "5451.0" "5399.8" "5130.9" "5399.4" "5030.7" "2755.2" "" "" "" "" "" "" "" "" "" "" "4405.1" "4446.1" "4608.5" "4036.4" "4545.4" "4960.3" "4336.4" "4463.0" "4613.8" "2755.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "189.435" "36" "28" "47" "28" "856" "96.7" "6.54" "187.53" "28" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "1.038" "1.013" "1.078" "1.059" "1.034" "1.008" "0.962" "0.893" "0.829" "3864.6" "4012.2" "3915.9" "4167.0" "4092.2" "3994.2" "3894.3" "3718.7" "3450.5" "3203.0" "" "" "" "" "" "" "" "" "" "" "3427.1" "3323.5" "3416.8" "3116.3" "3412.4" "3669.1" "3291.3" "3073.8" "3164.6" "3203.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "189.312" "21" "26" "41" "26" "1463" "164.6" "8.41" "172.61" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "" "Apoptosis" "1" "0" "1.022" "0.996" "1.057" "0.998" "0.961" "0.987" "0.988" "1.037" "0.616" "5027.3" "5137.6" "5004.7" "5312.5" "5016.8" "4832.5" "4962.2" "4966.0" "5212.6" "3096.5" "" "" "" "" "" "" "" "" "" "" "4458.1" "4255.7" "4366.9" "3973.1" "4183.3" "4439.2" "4193.9" "4104.7" "4780.6" "3096.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "189.214" "55" "18" "64" "17" "367" "40.5" "8.90" "248.56" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "Protein hydroxylation" "" "1" "1" "1.030" "1.036" "1.060" "1.047" "1.044" "1.016" "1.046" "0.986" "0.553" "6572.7" "6768.5" "6809.0" "6965.5" "6883.3" "6862.1" "6679.1" "6874.6" "6482.9" "3633.4" "" "" "" "" "" "" "" "" "" "" "5828.6" "5606.7" "5941.2" "5209.3" "5739.7" "6303.6" "5644.9" "5682.3" "5945.7" "3633.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "189.081" "45" "31" "55" "31" "719" "81.3" "6.46" "214.81" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "12" "0" "0.970" "1.020" "1.080" "1.072" "0.994" "1.502" "1.369" "1.338" "1.806" "4010.2" "3891.4" "4088.9" "4329.1" "4297.2" "3984.4" "6022.1" "5488.7" "5364.3" "7243.3" "" "" "" "" "" "" "" "" "" "" "3556.1" "3223.5" "3567.8" "3237.6" "3583.3" "3660.1" "5089.6" "4536.8" "4919.8" "7243.3" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "188.991" "26" "36" "48" "36" "1555" "177.1" "5.63" "170.37" "36" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "ER Quality Control Compartment (ERQC)" "IL-18 signaling pathway" "2" "0" "1.012" "0.978" "1.072" "1.062" "1.037" "1.129" "1.092" "1.025" "0.824" "3413.2" "3453.7" "3338.6" "3660.5" "3624.5" "3538.3" "3853.1" "3726.2" "3499.4" "2814.1" "" "" "" "" "" "" "" "" "" "" "3026.7" "2860.9" "2913.1" "2737.6" "3022.3" "3250.3" "3256.5" "3080.0" "3209.4" "2814.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "188.717" "37" "26" "89" "10" "583" "68.5" "6.37" "334.78" "26" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "Regulation of actin cytoskeleton" "4" "1" "0.959" "0.811" "0.861" "0.785" "0.827" "0.830" "0.839" "0.853" "0.548" "4192.2" "4018.3" "3400.7" "3610.7" "3289.5" "3468.4" "3477.4" "3516.4" "3575.5" "2296.6" "" "" "" "" "" "" "" "" "" "" "3717.5" "3328.6" "2967.3" "2700.3" "2743.0" "3186.1" "2939.0" "2906.5" "3279.3" "2296.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "188.559" "34" "20" "56" "20" "732" "81.2" "5.48" "229.81" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "Neutrophil degranulation; Eukaryotic Translation Termination" "" "2" "0" "1.045" "1.012" "0.987" "1.069" "1.054" "0.983" "1.013" "0.960" "0.553" "5755.7" "6017.2" "5824.9" "5680.3" "6155.5" "6068.7" "5655.5" "5831.6" "5523.2" "3181.3" "" "" "" "" "" "" "" "" "" "" "5104.1" "4984.4" "5082.5" "4248.1" "5132.9" "5574.8" "4779.8" "4820.2" "5065.6" "3181.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "188.281" "41" "23" "38" "17" "639" "65.4" "8.00" "149.49" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "Formation of the cornified envelope" "" "2" "3" "1.106" "1.325" "1.563" "0.922" "4.868" "0.923" "1.804" "1.218" "1.540" "2081.3" "2301.7" "2758.0" "3252.3" "1918.4" "10132.4" "1920.1" "3755.5" "2534.8" "3205.6" "" "" "" "" "" "" "" "" "" "" "1845.7" "1906.6" "2406.5" "2432.3" "1599.7" "9307.8" "1622.8" "3104.2" "2324.8" "3205.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "188.243" "24" "26" "35" "26" "1227" "140.4" "6.54" "147.85" "26" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "5" "0" "1.026" "0.973" "0.974" "0.986" "0.984" "0.993" "0.973" "0.998" "0.906" "3132.0" "3214.8" "3047.9" "3050.3" "3088.9" "3082.3" "3109.9" "3047.7" "3125.8" "2836.1" "" "" "" "" "" "" "" "" "" "" "2777.4" "2663.0" "2659.4" "2281.2" "2575.7" "2831.4" "2628.4" "2519.2" "2866.8" "2836.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "188.230" "34" "22" "47" "22" "650" "73.9" "4.88" "196.09" "22" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "3" "0" "1.046" "1.052" "1.046" "1.062" "1.064" "0.998" "1.026" "0.987" "0.657" "4677.0" "4891.5" "4918.6" "4894.3" "4968.7" "4975.7" "4669.0" "4799.6" "4614.5" "3072.5" "" "" "" "" "" "" "" "" "" "" "4147.5" "4051.9" "4291.7" "3660.3" "4143.2" "4570.7" "3946.0" "3967.2" "4232.1" "3072.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962903921157164287" "False" "High" "IsMasterProtein" "Q8IYD1" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B OS=Homo sapiens OX=9606 GN=GSPT2 PE=1 SV=2" "0.000" "False" "188.162" "41" "25" "68" "6" "628" "68.8" "5.43" "251.24" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf07145" "23708" "ENSG00000189369" "GSPT2" "hsa:23708; Q8IYD1; Q9H909; Q9NVY0; Q9NY44" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Translation factors" "5" "0" "1.071" "1.030" "1.121" "1.002" "1.046" "1.195" "1.068" "1.130" "1.523" "462.3" "494.9" "476.2" "518.1" "463.3" "483.5" "552.2" "493.9" "522.6" "703.9" "" "" "" "" "" "" "" "" "" "" "409.9" "410.0" "415.5" "387.5" "386.4" "444.2" "466.7" "408.3" "479.3" "703.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "188.087" "28" "29" "51" "29" "1338" "144.6" "5.76" "181.00" "29" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "0.930" "0.891" "0.897" "0.788" "0.669" "0.662" "0.570" "0.619" "1.810" "3382.1" "3145.8" "3012.7" "3034.6" "2666.7" "2262.8" "2239.4" "1928.2" "2093.7" "6122.1" "" "" "" "" "" "" "" "" "" "" "2999.1" "2605.9" "2628.7" "2269.5" "2223.7" "2078.6" "1892.6" "1593.8" "1920.2" "6122.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "187.783" "38" "16" "68" "15" "440" "48.1" "5.08" "278.58" "16" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "XBP1(S) activates chaperone genes; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "5" "1" "1.039" "0.997" "1.033" "1.022" "1.040" "1.003" "1.070" "1.027" "0.395" "5743.2" "5969.2" "5727.3" "5930.9" "5870.0" "5975.4" "5762.2" "6144.1" "5895.9" "2270.4" "" "" "" "" "" "" "" "" "" "" "5092.9" "4944.6" "4997.3" "4435.5" "4894.8" "5489.0" "4870.0" "5078.6" "5407.4" "2270.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "187.518" "21" "17" "50" "17" "1119" "117.0" "7.34" "206.02" "17" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "0.980" "1.017" "0.941" "0.988" "1.038" "0.955" "1.001" "1.007" "0.507" "7784.2" "7627.1" "7918.3" "7322.7" "7692.6" "8083.7" "7430.4" "7792.5" "7840.0" "3944.8" "" "" "" "" "" "" "" "" "" "" "6902.8" "6317.9" "6909.1" "5476.4" "6414.6" "7425.7" "6279.8" "6441.1" "7190.4" "3944.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.000" "False" "187.390" "45" "14" "55" "14" "282" "31.5" "4.55" "242.15" "14" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "0.959" "0.938" "0.942" "0.945" "0.983" "0.931" "0.991" "0.966" "0.466" "10257.8" "9839.9" "9622.8" "9661.3" "9698.4" "10084.4" "9548.0" "10161.7" "9907.6" "4779.8" "" "" "" "" "" "" "" "" "" "" "9096.4" "8150.9" "8396.4" "7225.4" "8087.2" "9263.6" "8069.6" "8399.3" "9086.6" "4779.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773020118127395212" "False" "High" "IsMasterProtein" "P30740" "Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1" "0.000" "False" "186.660" "51" "20" "56" "19" "379" "42.7" "6.28" "229.26" "20" "cell cycle OR cell proliferation;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00079" "1992" "ENSG00000021355" "SERPINB1" "A8K5L2; B4DNT0; hsa:1992; P30740; Q53FB9; Q5W0E1; Q9UDF8" "Neutrophil degranulation" "Vitamin D receptor pathway" "2" "0" "1.001" "1.034" "1.025" "1.017" "1.034" "1.034" "1.074" "1.008" "0.597" "7704.1" "7712.0" "7967.8" "7898.7" "7837.1" "7964.0" "7963.3" "8278.0" "7765.7" "4595.8" "" "" "" "" "" "" "" "" "" "" "6831.8" "6388.3" "6952.3" "5907.2" "6535.1" "7315.8" "6730.2" "6842.3" "7122.2" "4595.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "186.523" "48" "16" "70" "9" "425" "47.8" "5.05" "283.68" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "Transcriptional Regulation by E2F6; HCMV Early Events; Neddylation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "20" "7" "0.991" "1.014" "0.983" "0.988" "1.005" "1.019" "1.053" "0.990" "0.593" "8965.0" "8885.1" "9089.3" "8811.7" "8856.4" "9006.7" "9132.7" "9438.9" "8871.0" "5320.5" "" "" "" "" "" "" "" "" "" "" "7950.0" "7360.0" "7930.8" "6590.0" "7385.0" "8273.7" "7718.6" "7801.9" "8135.9" "5320.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "186.308" "63" "14" "139" "10" "199" "22.1" "8.13" "481.28" "14" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "9" "4" "0.984" "1.065" "0.974" "1.013" "1.013" "1.034" "1.073" "1.051" "0.596" "15798.6" "15553.0" "16825.0" "15386.6" "16001.6" "16004.7" "16335.2" "16946.6" "16598.9" "9419.2" "" "" "" "" "" "" "" "" "" "" "14009.9" "12883.4" "14680.6" "11507.1" "13343.1" "14702.1" "13805.8" "14007.6" "15223.5" "9419.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "185.887" "44" "13" "72" "13" "397" "41.3" "6.92" "283.32" "13" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Cholesterol biosynthesis" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "6" "0" "0.999" "0.987" "0.971" "0.963" "0.952" "0.971" "0.998" "1.010" "0.500" "6255.9" "6251.3" "6175.2" "6073.9" "6022.7" "5954.6" "6074.1" "6244.9" "6316.1" "3129.1" "" "" "" "" "" "" "" "" "" "" "5547.6" "5178.3" "5388.2" "4542.5" "5022.1" "5470.0" "5133.6" "5161.8" "5792.8" "3129.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "185.875" "52" "16" "57" "16" "365" "41.0" "5.16" "243.09" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "1.006" "1.090" "0.979" "1.035" "1.042" "1.028" "1.063" "1.092" "0.847" "9225.9" "9284.2" "10059.1" "9028.4" "9545.9" "9616.2" "9483.6" "9810.8" "10073.1" "7817.3" "" "" "" "" "" "" "" "" "" "" "8181.3" "7690.6" "8777.0" "6752.0" "7960.0" "8833.6" "8015.2" "8109.3" "9238.5" "7817.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "185.507" "30" "37" "55" "37" "1197" "135.6" "8.43" "201.72" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Retinoblastoma gene in cancer" "3" "0" "1.001" "0.926" "0.993" "0.922" "0.928" "0.990" "0.485" "1.018" "9.964" "3155.7" "3157.9" "2922.6" "3134.1" "2909.8" "2929.0" "3124.6" "1531.1" "3212.9" "31442.4" "" "" "" "" "" "" "" "" "" "" "2798.4" "2615.9" "2550.1" "2343.9" "2426.3" "2690.6" "2640.8" "1265.6" "2946.7" "31442.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "185.487" "57" "15" "63" "15" "333" "35.1" "8.38" "250.10" "15" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "Respiratory electron transport" "" "1" "0" "1.033" "1.003" "1.019" "1.025" "0.998" "1.024" "1.056" "0.978" "0.691" "7886.8" "8148.7" "7909.4" "8037.7" "8086.9" "7874.1" "8073.7" "8329.0" "7715.5" "5448.8" "" "" "" "" "" "" "" "" "" "" "6993.9" "6750.0" "6901.3" "6011.2" "6743.3" "7233.2" "6823.6" "6884.5" "7076.2" "5448.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "185.298" "42" "19" "47" "12" "487" "55.6" "5.07" "180.65" "19" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "Signaling by Hippo" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "4" "9" "0.986" "1.016" "1.013" "1.027" "1.093" "1.109" "1.138" "1.093" "0.922" "6063.2" "5980.6" "6162.8" "6141.4" "6224.6" "6629.6" "6726.4" "6899.9" "6626.0" "5591.6" "" "" "" "" "" "" "" "" "" "" "5376.7" "4954.0" "5377.4" "4593.0" "5190.4" "6090.0" "5684.8" "5703.2" "6076.9" "5591.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "184.921" "48" "8" "52" "8" "264" "29.2" "5.97" "259.28" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.007" "1.020" "1.037" "1.080" "1.052" "1.035" "1.048" "0.934" "0.610" "5675.4" "5717.7" "5791.0" "5884.2" "6126.8" "5969.4" "5872.1" "5947.2" "5302.8" "3463.1" "" "" "" "" "" "" "" "" "" "" "5032.8" "4736.3" "5053.0" "4400.6" "5108.9" "5483.6" "4962.9" "4915.8" "4863.4" "3463.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "184.662" "31" "21" "48" "17" "906" "99.6" "6.54" "179.40" "21" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "Spry regulation of FGF signaling; Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Signaling by CSF1 (M-CSF) in myeloid cells; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "39" "2" "1.075" "1.029" "1.056" "1.079" "1.045" "1.044" "1.041" "0.987" "0.596" "3687.7" "3965.0" "3794.5" "3893.1" "3979.4" "3853.7" "3850.9" "3838.5" "3639.0" "2197.0" "" "" "" "" "" "" "" "" "" "" "3270.2" "3284.4" "3310.9" "2911.5" "3318.3" "3540.1" "3254.6" "3172.8" "3337.4" "2197.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "184.093" "39" "23" "45" "23" "694" "75.4" "7.66" "209.83" "23" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "0" "0.976" "0.981" "1.041" "1.009" "0.953" "1.001" "0.909" "0.979" "1.800" "4439.8" "4334.0" "4357.6" "4620.3" "4481.5" "4233.3" "4445.8" "4037.9" "4347.3" "7991.9" "" "" "" "" "" "" "" "" "" "" "3937.1" "3590.1" "3802.2" "3455.4" "3736.9" "3888.7" "3757.4" "3337.6" "3987.1" "7991.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "361994698644895597" "False" "High" "IsMasterProtein" "P07355" "Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2" "0.000" "False" "183.620" "58" "19" "75" "19" "339" "38.6" "7.75" "277.88" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00191" "302" "ENSG00000182718" "ANXA2" "hsa:302; P07355; Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Dissolution of Fibrin Clot" "Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation" "7" "0" "0.971" "0.992" "0.949" "1.013" "1.055" "0.986" "1.062" "1.024" "0.595" "6856.0" "6659.4" "6804.3" "6506.0" "6944.4" "7234.6" "6759.3" "7280.9" "7017.4" "4080.8" "" "" "" "" "" "" "" "" "" "" "6079.7" "5516.3" "5937.1" "4865.6" "5790.7" "6645.8" "5712.7" "6018.1" "6436.0" "4080.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "183.252" "59" "15" "47" "15" "290" "31.4" "8.07" "201.01" "15" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "10" "0" "0.999" "1.017" "1.005" "1.028" "1.044" "1.070" "1.070" "1.083" "0.642" "6853.4" "6843.6" "6967.0" "6888.9" "7046.8" "7157.7" "7330.4" "7336.0" "7421.5" "4402.2" "" "" "" "" "" "" "" "" "" "" "6077.4" "5668.9" "6079.1" "5152.0" "5876.1" "6575.1" "6195.4" "6063.7" "6806.6" "4402.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "183.228" "45" "22" "91" "10" "428" "49.0" "5.67" "295.63" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RHOBTB2 GTPase cycle" "" "5" "12" "1.046" "1.067" "1.065" "1.062" "1.038" "1.062" "1.068" "1.019" "0.803" "8685.7" "9081.9" "9269.3" "9249.8" "9226.5" "9019.8" "9224.7" "9277.0" "8852.2" "6977.9" "" "" "" "" "" "" "" "" "" "" "7702.3" "7523.0" "8087.9" "6917.6" "7693.6" "8285.7" "7796.4" "7668.1" "8118.7" "6977.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "183.048" "62" "10" "50" "10" "241" "26.4" "4.79" "215.23" "10" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Downstream TCR signaling; UCH proteinases; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "1.016" "1.030" "1.005" "1.046" "1.033" "1.046" "1.032" "1.021" "0.645" "4491.9" "4565.7" "4626.8" "4514.9" "4697.7" "4638.0" "4696.5" "4637.0" "4587.4" "2897.4" "" "" "" "" "" "" "" "" "" "" "3983.4" "3782.0" "4037.1" "3376.6" "3917.3" "4260.5" "3969.3" "3832.8" "4207.2" "2897.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "182.656" "62" "11" "175" "10" "231" "24.4" "7.18" "762.08" "11" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "1" "0.963" "0.850" "1.000" "0.958" "0.927" "0.932" "1.015" "0.975" "0.608" "19353.3" "18635.8" "16450.1" "19354.2" "18534.6" "17937.8" "18037.8" "19636.6" "18872.8" "11765.7" "" "" "" "" "" "" "" "" "" "" "17162.1" "15437.0" "14353.5" "14474.4" "15455.4" "16477.9" "15244.8" "16231.0" "17308.9" "11765.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "182.583" "32" "34" "47" "34" "1174" "133.8" "6.87" "154.01" "34" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.028" "0.985" "1.050" "1.044" "0.999" "0.948" "0.929" "0.919" "1.258" "5336.7" "5485.1" "5257.5" "5604.4" "5574.0" "5330.8" "5056.7" "4955.4" "4906.9" "6713.0" "" "" "" "" "" "" "" "" "" "" "4732.5" "4543.6" "4587.5" "4191.4" "4647.9" "4897.0" "4273.7" "4096.0" "4500.3" "6713.0" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "182.160" "33" "26" "47" "26" "944" "106.8" "6.14" "187.18" "26" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "N-glycan biosynthesis" "5" "0" "0.964" "0.920" "0.958" "0.943" "0.901" "1.107" "0.985" "0.978" "2.369" "4272.8" "4119.6" "3932.3" "4091.3" "4029.2" "3849.7" "4729.1" "4208.2" "4180.7" "10123.3" "" "" "" "" "" "" "" "" "" "" "3789.0" "3412.5" "3431.1" "3059.7" "3359.8" "3536.4" "3996.8" "3478.4" "3834.3" "10123.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "181.991" "47" "26" "37" "26" "684" "75.4" "6.61" "159.29" "26" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "0.971" "0.940" "0.958" "0.906" "0.890" "0.929" "0.925" "0.929" "1.017" "3609.4" "3503.6" "3391.1" "3457.2" "3270.6" "3212.3" "3353.9" "3340.2" "3354.2" "3671.0" "" "" "" "" "" "" "" "" "" "" "3200.7" "2902.2" "2958.9" "2585.5" "2727.2" "2950.8" "2834.6" "2760.9" "3076.2" "3671.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "181.641" "48" "19" "54" "19" "459" "51.8" "5.43" "197.71" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Attenuation phase" "Androgen receptor signaling pathway" "6" "0" "0.969" "0.972" "0.929" "0.951" "0.904" "1.035" "0.788" "0.987" "4.964" "4831.8" "4684.0" "4696.9" "4488.0" "4593.9" "4369.7" "4999.8" "3806.8" "4768.7" "23984.0" "" "" "" "" "" "" "" "" "" "" "4284.7" "3880.0" "4098.3" "3356.5" "3830.7" "4014.1" "4225.6" "3146.6" "4373.5" "23984.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "181.580" "39" "20" "44" "20" "585" "64.9" "8.87" "186.42" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "0" "1.005" "1.081" "1.012" "1.060" "1.055" "0.965" "1.022" "0.982" "0.771" "5154.1" "5180.5" "5571.7" "5217.5" "5465.2" "5438.3" "4975.8" "5267.6" "5063.6" "3973.4" "" "" "" "" "" "" "" "" "" "" "4570.5" "4291.3" "4861.6" "3902.0" "4557.2" "4995.7" "4205.4" "4354.0" "4644.0" "3973.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "181.419" "37" "19" "79" "19" "488" "52.7" "5.68" "275.13" "19" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "1.068" "1.059" "0.982" "1.004" "0.969" "1.036" "0.989" "1.005" "1.604" "5055.8" "5401.9" "5352.5" "4966.8" "5074.0" "4900.8" "5239.2" "5000.6" "5078.9" "8107.6" "" "" "" "" "" "" "" "" "" "" "4483.3" "4474.7" "4670.3" "3714.5" "4231.0" "4501.9" "4428.0" "4133.3" "4658.1" "8107.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "181.358" "36" "15" "80" "13" "420" "46.4" "9.57" "307.94" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "0" "0.977" "0.960" "0.932" "0.924" "0.871" "0.810" "0.910" "0.947" "0.571" "9324.7" "9112.4" "8952.3" "8686.6" "8619.0" "8118.8" "7555.4" "8483.4" "8833.0" "5324.3" "" "" "" "" "" "" "" "" "" "" "8268.9" "7548.3" "7811.3" "6496.4" "7187.0" "7458.0" "6385.5" "7012.2" "8101.0" "5324.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "181.312" "50" "16" "68" "15" "466" "52.1" "5.52" "287.70" "16" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "3" "1" "1.015" "1.035" "1.023" "1.028" "0.987" "0.989" "1.017" "1.037" "0.798" "6901.2" "7001.8" "7140.4" "7058.3" "7095.6" "6813.2" "6821.8" "7017.5" "7154.0" "5505.9" "" "" "" "" "" "" "" "" "" "" "6119.8" "5799.9" "6230.4" "5278.7" "5916.8" "6258.6" "5765.5" "5800.5" "6561.2" "5505.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "181.254" "35" "18" "48" "18" "609" "67.3" "6.57" "199.10" "18" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "OAS antiviral response" "Phosphodiesterases in neuronal function" "2" "0" "1.025" "1.015" "1.064" "1.074" "0.999" "1.029" "1.030" "0.980" "0.682" "4583.1" "4697.6" "4651.5" "4878.6" "4923.6" "4578.3" "4714.7" "4719.4" "4493.0" "3125.7" "" "" "" "" "" "" "" "" "" "" "4064.2" "3891.3" "4058.7" "3648.5" "4105.6" "4205.7" "3984.7" "3900.9" "4120.7" "3125.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "181.216" "33" "22" "67" "21" "707" "76.1" "9.44" "234.65" "22" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "mRNA processing; Type 2 papillary renal cell carcinoma" "4" "1" "1.010" "0.952" "0.986" "0.950" "0.972" "0.938" "0.742" "0.937" "4.090" "5538.0" "5591.6" "5274.9" "5462.3" "5261.1" "5384.6" "5194.6" "4107.6" "5190.9" "22651.4" "" "" "" "" "" "" "" "" "" "" "4911.0" "4631.8" "4602.6" "4085.1" "4387.1" "4946.3" "4390.2" "3395.2" "4760.7" "22651.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "180.677" "41" "30" "60" "30" "745" "86.9" "6.92" "206.85" "30" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "6" "0" "1.012" "0.969" "0.986" "0.983" "0.946" "0.962" "1.029" "0.938" "0.531" "6446.2" "6522.8" "6246.3" "6358.8" "6334.3" "6100.1" "6200.6" "6636.2" "6048.3" "3425.7" "" "" "" "" "" "" "" "" "" "" "5716.4" "5403.2" "5450.2" "4755.5" "5282.0" "5603.6" "5240.5" "5485.3" "5547.1" "3425.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "180.496" "23" "26" "42" "25" "1341" "151.8" "6.43" "177.33" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "" "2" "1" "0.967" "0.937" "0.900" "0.895" "0.889" "0.880" "0.909" "0.946" "0.531" "5498.0" "5319.0" "5149.2" "4946.9" "4920.1" "4888.1" "4836.4" "4997.4" "5199.7" "2919.2" "" "" "" "" "" "" "" "" "" "" "4875.5" "4406.0" "4492.9" "3699.6" "4102.7" "4490.2" "4087.6" "4130.7" "4768.8" "2919.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "180.270" "39" "22" "49" "22" "641" "70.0" "8.38" "190.81" "22" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "mRNA Splicing - Major Pathway" "" "1" "0" "0.971" "0.974" "0.982" "0.977" "0.968" "0.978" "0.982" "0.981" "0.459" "5825.4" "5658.3" "5672.1" "5721.9" "5689.3" "5639.0" "5698.9" "5720.1" "5716.3" "2673.3" "" "" "" "" "" "" "" "" "" "" "5165.8" "4687.1" "4949.2" "4279.2" "4744.1" "5180.0" "4816.5" "4728.0" "5242.7" "2673.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "180.244" "57" "15" "98" "15" "239" "26.5" "7.81" "331.24" "15" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "0.981" "1.002" "0.944" "0.978" "1.003" "0.973" "1.006" "1.057" "0.464" "10807.6" "10601.3" "10831.2" "10207.8" "10564.9" "10844.1" "10513.3" "10876.9" "11422.2" "5019.8" "" "" "" "" "" "" "" "" "" "" "9584.0" "8781.6" "9450.8" "7634.0" "8809.7" "9961.5" "8885.4" "8990.6" "10475.7" "5019.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "180.131" "30" "23" "37" "23" "962" "107.8" "4.91" "156.92" "23" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "" "3" "0" "1.014" "1.040" "0.969" "1.007" "1.026" "0.988" "0.989" "1.028" "1.873" "2742.8" "2780.9" "2852.6" "2658.5" "2761.4" "2815.4" "2709.8" "2712.4" "2820.2" "5137.2" "" "" "" "" "" "" "" "" "" "" "2432.3" "2303.6" "2489.1" "1988.2" "2302.6" "2586.3" "2290.2" "2242.0" "2586.5" "5137.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "180.042" "75" "12" "52" "10" "206" "22.2" "9.38" "228.05" "12" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "" "Orexin receptor pathway" "1" "2" "0.937" "0.934" "0.927" "0.893" "0.901" "0.831" "0.903" "0.950" "0.469" "5674.6" "5315.9" "5297.8" "5262.0" "5066.1" "5114.7" "4714.0" "5126.0" "5390.6" "2663.6" "" "" "" "" "" "" "" "" "" "" "5032.1" "4403.4" "4622.6" "3935.3" "4224.5" "4698.4" "3984.0" "4237.0" "4943.9" "2663.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6062730820723703914" "False" "High" "IsMasterProtein" "P82094" "TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2" "0.000" "False" "179.684" "36" "37" "49" "37" "1093" "122.8" "4.92" "184.33" "37" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf12325, Pf12329" "7110" "ENSG00000144747" "TMF1" "B7ZLJ2; hsa:7110; P82094; Q17R87; Q59GK0" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.986" "0.936" "0.929" "0.880" "0.892" "0.848" "0.901" "0.919" "0.581" "5724.8" "5646.8" "5358.3" "5319.4" "5037.9" "5105.7" "4852.9" "5159.3" "5258.4" "3326.1" "" "" "" "" "" "" "" "" "" "" "5076.7" "4677.5" "4675.4" "3978.2" "4200.9" "4690.1" "4101.5" "4264.5" "4822.7" "3326.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "179.672" "49" "26" "47" "24" "586" "66.4" "5.16" "194.32" "26" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "RHOD GTPase cycle; RHOF GTPase cycle; Meiotic synapsis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "14" "1" "1.082" "1.052" "1.024" "1.033" "1.015" "0.934" "0.918" "0.973" "0.722" "4883.5" "5285.8" "5135.9" "5000.3" "5045.8" "4957.5" "4559.8" "4483.0" "4749.3" "3526.1" "" "" "" "" "" "" "" "" "" "" "4330.6" "4378.5" "4481.3" "3739.6" "4207.5" "4554.1" "3853.8" "3705.5" "4355.7" "3526.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "179.566" "62" "18" "60" "18" "338" "38.3" "5.53" "253.75" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "1" "0" "0.993" "1.029" "0.977" "0.975" "0.974" "1.029" "0.999" "1.021" "1.574" "6414.5" "6366.9" "6600.6" "6268.5" "6256.7" "6250.3" "6602.9" "6408.2" "6546.9" "10096.1" "" "" "" "" "" "" "" "" "" "" "5688.2" "5274.0" "5759.4" "4688.0" "5217.2" "5741.6" "5580.5" "5296.8" "6004.4" "10096.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "179.531" "38" "27" "50" "27" "798" "88.8" "6.25" "183.44" "27" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "1.028" "0.925" "0.999" "0.970" "0.912" "0.969" "0.398" "0.992" "11.238" "2686.1" "2761.1" "2484.5" "2684.4" "2604.4" "2449.0" "2603.0" "1068.9" "2664.2" "30186.4" "" "" "" "" "" "" "" "" "" "" "2382.0" "2287.2" "2167.9" "2007.6" "2171.7" "2249.7" "2200.0" "883.5" "2443.4" "30186.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "179.429" "22" "18" "37" "18" "1038" "119.4" "4.82" "168.34" "18" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "1.003" "0.942" "1.032" "0.999" "0.984" "0.957" "0.876" "0.833" "2.297" "3352.2" "3362.8" "3156.2" "3458.5" "3349.6" "3299.8" "3207.5" "2937.6" "2791.7" "7701.0" "" "" "" "" "" "" "" "" "" "" "2972.7" "2785.6" "2754.0" "2586.5" "2793.1" "3031.3" "2710.8" "2428.2" "2560.4" "7701.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "179.100" "40" "18" "42" "18" "437" "50.1" "6.67" "167.57" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "Translation factors" "3" "0" "1.002" "1.082" "0.936" "0.921" "0.928" "0.982" "0.761" "1.031" "4.050" "3879.2" "3887.9" "4197.6" "3631.9" "3574.2" "3599.3" "3808.3" "2951.2" "3998.4" "15711.8" "" "" "" "" "" "" "" "" "" "" "3440.0" "3220.5" "3662.6" "2716.2" "2980.4" "3306.4" "3218.6" "2439.4" "3667.0" "15711.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "High" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.000" "False" "177.906" "20" "18" "35" "18" "1017" "110.2" "4.74" "144.21" "18" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "1.020" "0.976" "1.024" "1.007" "0.968" "0.942" "0.986" "0.944" "0.279" "4148.9" "4230.8" "4048.0" "4250.4" "4178.4" "4018.1" "3908.2" "4089.0" "3914.7" "1158.3" "" "" "" "" "" "" "" "" "" "" "3679.2" "3504.6" "3532.1" "3178.7" "3484.2" "3691.1" "3303.0" "3379.8" "3590.3" "1158.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "177.906" "59" "15" "82" "15" "246" "27.4" "6.76" "325.80" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.056" "1.077" "1.011" "1.069" "1.091" "1.062" "1.063" "1.059" "0.593" "8457.4" "8933.8" "9108.6" "8550.0" "9039.7" "9229.5" "8980.3" "8991.6" "8956.5" "5012.0" "" "" "" "" "" "" "" "" "" "" "7499.8" "7400.3" "7947.7" "6394.2" "7537.9" "8478.3" "7589.8" "7432.2" "8214.4" "5012.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "177.648" "38" "26" "42" "26" "783" "85.9" "7.77" "167.42" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Mitochondrial RNA degradation" "Pyrimidine metabolism; miRNA degrading enzymes" "3" "0" "0.938" "0.963" "0.937" "0.907" "0.910" "0.664" "0.618" "0.643" "1.246" "3465.5" "3251.0" "3336.7" "3245.8" "3144.0" "3154.8" "2301.0" "2141.9" "2229.3" "4319.5" "" "" "" "" "" "" "" "" "" "" "3073.2" "2693.0" "2911.4" "2427.4" "2621.7" "2898.1" "1944.7" "1770.4" "2044.6" "4319.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "177.435" "70" "17" "40" "17" "276" "30.6" "7.21" "176.51" "17" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "Neutrophil degranulation" "" "1" "0" "1.041" "1.122" "1.001" "1.072" "1.075" "1.048" "1.130" "1.116" "0.508" "5498.6" "5723.5" "6167.8" "5502.5" "5892.0" "5912.5" "5762.8" "6213.0" "6136.4" "2793.6" "" "" "" "" "" "" "" "" "" "" "4876.0" "4741.1" "5381.7" "4115.1" "4913.1" "5431.3" "4870.5" "5135.5" "5627.9" "2793.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "177.185" "46" "23" "58" "15" "534" "60.6" "6.83" "233.34" "23" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Factors involved in megakaryocyte development and platelet production" "Insulin signaling" "2" "9" "1.013" "0.976" "1.102" "1.041" "1.014" "1.213" "1.221" "1.162" "0.970" "6132.4" "6209.2" "5983.6" "6760.4" "6386.2" "6218.2" "7440.3" "7485.8" "7124.8" "5946.5" "" "" "" "" "" "" "" "" "" "" "5438.1" "5143.4" "5221.0" "5055.9" "5325.2" "5712.1" "6288.3" "6187.6" "6534.4" "5946.5" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "176.433" "42" "11" "75" "11" "258" "27.3" "6.40" "296.25" "11" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "0.963" "0.969" "0.978" "0.973" "1.008" "0.848" "0.943" "0.974" "0.542" "12542.1" "12072.6" "12156.0" "12264.4" "12202.7" "12644.3" "10634.0" "11828.0" "12220.8" "6795.8" "" "" "" "" "" "" "" "" "" "" "11122.1" "10000.3" "10606.7" "9172.1" "10175.4" "11615.2" "8987.4" "9776.7" "11208.2" "6795.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "176.429" "42" "24" "51" "24" "659" "72.2" "7.64" "183.73" "24" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.039" "0.980" "1.078" "1.041" "0.996" "1.038" "1.018" "0.941" "0.554" "3132.9" "3256.0" "3071.4" "3377.9" "3260.2" "3119.5" "3252.4" "3190.8" "2947.9" "1735.1" "" "" "" "" "" "" "" "" "" "" "2778.2" "2697.1" "2679.9" "2526.2" "2718.6" "2865.6" "2748.8" "2637.4" "2703.6" "1735.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "176.216" "41" "18" "36" "18" "575" "58.9" "7.49" "152.36" "18" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; Fructose catabolism" "Novel intracellular components of RIG-I-like receptor pathway" "5" "0" "1.045" "1.042" "1.088" "1.080" "1.027" "1.050" "1.059" "0.969" "0.550" "3544.9" "3705.1" "3694.2" "3857.7" "3826.8" "3640.6" "3722.3" "3753.8" "3435.0" "1949.4" "" "" "" "" "" "" "" "" "" "" "3143.6" "3069.1" "3223.4" "2885.0" "3191.1" "3344.3" "3145.9" "3102.7" "3150.4" "1949.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "176.102" "45" "19" "58" "19" "471" "53.1" "6.23" "248.14" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "3" "0" "0.996" "1.041" "0.972" "1.031" "1.077" "0.983" "1.069" "1.048" "0.534" "8022.2" "7990.5" "8349.3" "7793.8" "8272.6" "8638.5" "7887.7" "8574.9" "8405.7" "4283.2" "" "" "" "" "" "" "" "" "" "" "7114.0" "6618.9" "7285.2" "5828.8" "6898.2" "7935.5" "6666.3" "7087.8" "7709.2" "4283.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "175.794" "29" "35" "47" "35" "1243" "140.3" "8.22" "173.18" "35" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "1.010" "1.037" "1.043" "1.035" "1.051" "0.982" "1.044" "1.000" "0.602" "6978.2" "7048.9" "7233.7" "7281.2" "7223.1" "7335.3" "6851.4" "7282.3" "6976.1" "4203.5" "" "" "" "" "" "" "" "" "" "" "6188.1" "5839.0" "6311.7" "5445.4" "6023.1" "6738.3" "5790.5" "6019.3" "6398.0" "4203.5" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "175.719" "56" "11" "61" "11" "243" "27.3" "5.08" "267.92" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "0.968" "0.898" "0.917" "0.871" "0.907" "0.803" "0.895" "0.879" "0.271" "7571.6" "7331.2" "6801.0" "6942.1" "6596.4" "6871.1" "6082.3" "6775.8" "6653.3" "2053.2" "" "" "" "" "" "" "" "" "" "" "6714.3" "6072.8" "5934.2" "5191.8" "5500.5" "6311.9" "5140.5" "5600.6" "6101.9" "2053.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "175.162" "53" "18" "44" "16" "369" "40.9" "7.44" "191.39" "18" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "3" "1.014" "1.037" "1.051" "1.074" "1.044" "1.054" "1.040" "0.995" "0.571" "4001.5" "4058.0" "4149.3" "4206.7" "4295.7" "4179.4" "4216.4" "4163.3" "3980.5" "2285.1" "" "" "" "" "" "" "" "" "" "" "3548.4" "3361.5" "3620.5" "3146.0" "3582.0" "3839.3" "3563.5" "3441.3" "3650.7" "2285.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "175.024" "42" "23" "52" "23" "583" "63.4" "8.28" "209.65" "23" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "0.942" "0.919" "0.986" "0.946" "0.947" "0.964" "0.891" "0.868" "0.698" "5914.9" "5573.0" "5434.3" "5831.3" "5593.4" "5601.4" "5701.1" "5267.4" "5133.4" "4128.1" "" "" "" "" "" "" "" "" "" "" "5245.2" "4616.4" "4741.7" "4361.1" "4664.1" "5145.5" "4818.3" "4353.9" "4708.0" "4128.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "174.908" "29" "27" "54" "16" "915" "102.6" "5.47" "199.00" "27" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "SUMOylation of transcription cofactors" "Interleukin-1 (IL-1) structural pathway" "2" "8" "0.914" "0.873" "0.947" "0.857" "0.805" "0.769" "0.852" "0.924" "1.301" "4579.8" "4184.9" "4000.1" "4337.9" "3924.6" "3688.5" "3519.7" "3899.8" "4232.2" "5959.2" "" "" "" "" "" "" "" "" "" "" "4061.3" "3466.5" "3490.3" "3244.2" "3272.6" "3388.3" "2974.7" "3223.4" "3881.5" "5959.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "174.796" "25" "27" "41" "27" "1264" "140.4" "7.59" "151.89" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Cytosolic tRNA aminoacylation" "Amino acid metabolism" "2" "0" "0.954" "0.968" "1.078" "0.975" "0.929" "1.061" "0.918" "0.969" "2.665" "2793.8" "2665.0" "2704.2" "3012.5" "2723.7" "2596.1" "2964.2" "2565.1" "2705.9" "7445.4" "" "" "" "" "" "" "" "" "" "" "2477.5" "2207.5" "2359.6" "2252.9" "2271.2" "2384.8" "2505.2" "2120.2" "2481.7" "7445.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "174.748" "35" "25" "51" "25" "807" "89.4" "7.30" "192.44" "25" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "" "2" "0" "0.985" "1.021" "0.915" "0.900" "0.906" "0.926" "0.987" "0.981" "1.153" "4105.1" "4043.0" "4189.5" "3757.3" "3696.5" "3717.5" "3800.2" "4051.4" "4025.2" "4734.6" "" "" "" "" "" "" "" "" "" "" "3640.3" "3349.0" "3655.5" "2810.0" "3082.3" "3415.0" "3211.7" "3348.8" "3691.7" "4734.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "174.719" "36" "21" "39" "21" "736" "79.6" "8.84" "154.69" "21" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "10" "0" "1.030" "1.028" "1.056" "1.030" "1.065" "1.000" "1.027" "0.970" "0.590" "3416.7" "3517.8" "3511.1" "3608.1" "3518.2" "3638.5" "3416.3" "3509.2" "3314.9" "2017.4" "" "" "" "" "" "" "" "" "" "" "3029.9" "2914.0" "3063.6" "2698.4" "2933.7" "3342.4" "2887.3" "2900.6" "3040.2" "2017.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "174.378" "51" "21" "42" "20" "483" "53.0" "7.71" "161.42" "21" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Metabolism of folate and pterines; Carnitine synthesis" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "13" "0" "1.059" "1.062" "1.046" "1.037" "1.103" "1.078" "1.133" "1.075" "0.539" "3882.7" "4111.4" "4124.8" "4059.6" "4026.1" "4284.3" "4187.2" "4398.0" "4174.7" "2092.6" "" "" "" "" "" "" "" "" "" "" "3443.1" "3405.7" "3599.1" "3036.0" "3357.2" "3935.6" "3538.8" "3635.2" "3828.8" "2092.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "173.937" "66" "15" "152" "9" "245" "27.7" "4.78" "480.78" "15" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "19" "0" "1.028" "1.058" "0.972" "1.094" "1.016" "0.962" "0.990" "1.007" "0.721" "4832.7" "4966.6" "5114.9" "4699.7" "5288.2" "4909.8" "4648.8" "4783.0" "4867.8" "3484.6" "" "" "" "" "" "" "" "" "" "" "4285.6" "4114.1" "4463.0" "3514.8" "4409.7" "4510.2" "3929.0" "3953.5" "4464.4" "3484.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "173.889" "45" "16" "40" "16" "430" "48.2" "5.05" "162.84" "16" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "Neutrophil degranulation; Neurexins and neuroligins; Caspase-mediated cleavage of cytoskeletal proteins" "T-cell receptor signaling pathway" "4" "0" "1.016" "0.992" "1.025" "0.992" "1.012" "0.970" "0.926" "0.956" "1.745" "3156.7" "3206.9" "3132.8" "3236.1" "3129.8" "3194.9" "3062.5" "2922.0" "3018.0" "5508.1" "" "" "" "" "" "" "" "" "" "" "2799.3" "2656.4" "2733.5" "2420.1" "2609.9" "2934.8" "2588.3" "2415.2" "2767.9" "5508.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "173.698" "56" "23" "56" "23" "474" "52.4" "5.92" "218.71" "23" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "8" "0" "1.046" "1.037" "1.035" "1.091" "1.118" "1.080" "1.084" "1.100" "0.521" "4689.9" "4905.7" "4863.5" "4854.0" "5116.1" "5242.2" "5067.4" "5083.1" "5157.3" "2441.9" "" "" "" "" "" "" "" "" "" "" "4158.9" "4063.7" "4243.6" "3630.1" "4266.1" "4815.5" "4282.8" "4201.6" "4730.0" "2441.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "173.344" "42" "33" "51" "33" "843" "96.6" "6.86" "178.47" "33" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "IL-18 signaling pathway; Glycogen synthesis and degradation" "4" "0" "0.980" "0.959" "0.965" "1.003" "0.959" "0.883" "0.919" "0.884" "0.529" "4675.4" "4581.8" "4483.5" "4514.0" "4691.3" "4485.8" "4127.1" "4298.5" "4135.1" "2471.2" "" "" "" "" "" "" "" "" "" "" "4146.0" "3795.4" "3912.1" "3375.9" "3911.9" "4120.7" "3488.0" "3553.0" "3792.4" "2471.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "172.821" "36" "24" "38" "20" "644" "66.0" "8.12" "154.99" "24" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Formation of the cornified envelope; Neutrophil degranulation" "Corticotropin-releasing hormone signaling pathway" "4" "2" "0.733" "1.371" "2.250" "0.919" "2.279" "1.074" "0.549" "1.147" "1.826" "3106.8" "2277.2" "4258.9" "6991.9" "2855.3" "7080.0" "3336.6" "1706.7" "3563.2" "5674.0" "" "" "" "" "" "" "" "" "" "" "2755.1" "1886.3" "3716.1" "5229.0" "2381.0" "6503.8" "2819.9" "1410.7" "3267.9" "5674.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "172.757" "52" "15" "27" "15" "399" "44.5" "5.05" "134.12" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "1.050" "1.056" "1.049" "1.050" "1.023" "1.103" "1.051" "1.055" "0.872" "2419.7" "2541.7" "2556.1" "2538.6" "2540.0" "2475.2" "2668.8" "2542.0" "2553.1" "2111.1" "" "" "" "" "" "" "" "" "" "" "2145.8" "2105.5" "2230.3" "1898.5" "2118.0" "2273.8" "2255.5" "2101.1" "2341.5" "2111.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "172.016" "49" "24" "45" "24" "480" "52.2" "7.24" "172.77" "24" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Pyrimidine biosynthesis" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "0" "1.002" "1.016" "1.004" "1.010" "0.980" "0.989" "1.030" "0.977" "0.513" "6071.2" "6083.2" "6170.6" "6094.9" "6133.8" "5947.6" "6004.5" "6253.5" "5930.1" "3115.1" "" "" "" "" "" "" "" "" "" "" "5383.8" "5039.0" "5384.1" "4558.2" "5114.8" "5463.5" "5074.7" "5169.0" "5438.7" "3115.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "171.668" "35" "32" "36" "31" "1410" "152.4" "8.60" "133.13" "32" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Signaling by ALK fusions and activated point mutants" "Ectoderm differentiation" "2" "1" "0.961" "0.894" "0.922" "0.827" "0.827" "0.783" "0.843" "0.900" "0.524" "4210.9" "4045.1" "3764.1" "3883.7" "3481.6" "3482.4" "3297.4" "3549.5" "3789.0" "2208.0" "" "" "" "" "" "" "" "" "" "" "3734.2" "3350.8" "3284.4" "2904.5" "2903.2" "3199.0" "2786.8" "2933.9" "3475.0" "2208.0" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "171.568" "38" "18" "41" "18" "517" "58.2" "7.49" "189.96" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "" "32" "0" "0.951" "0.969" "0.925" "0.926" "0.958" "0.953" "0.920" "0.944" "0.596" "4422.7" "4205.3" "4286.1" "4088.8" "4093.8" "4237.2" "4215.2" "4068.7" "4176.7" "2634.2" "" "" "" "" "" "" "" "" "" "" "3922.0" "3483.5" "3739.8" "3057.9" "3413.7" "3892.4" "3562.5" "3363.1" "3830.6" "2634.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "171.287" "48" "22" "38" "22" "580" "61.1" "9.01" "146.31" "22" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "0.928" "0.920" "0.864" "0.879" "0.912" "0.835" "0.907" "0.978" "1.052" "4093.9" "3799.5" "3766.2" "3537.4" "3600.0" "3734.7" "3418.8" "3714.0" "4005.2" "4306.8" "" "" "" "" "" "" "" "" "" "" "3630.4" "3147.3" "3286.2" "2645.5" "3001.9" "3430.8" "2889.4" "3069.9" "3673.3" "4306.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "171.154" "57" "22" "38" "22" "442" "49.4" "8.18" "163.00" "22" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "Mitochondrial protein degradation; Nicotinate metabolism" "" "2" "0" "1.024" "1.036" "1.019" "1.048" "1.087" "1.036" "1.061" "0.950" "0.408" "5023.1" "5144.1" "5206.2" "5120.0" "5264.9" "5458.5" "5206.4" "5331.5" "4770.5" "2047.6" "" "" "" "" "" "" "" "" "" "" "4454.4" "4261.1" "4542.6" "3829.1" "4390.2" "5014.2" "4400.2" "4406.9" "4375.2" "2047.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "171.059" "49" "24" "39" "24" "579" "65.5" "7.06" "154.66" "24" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "5" "0" "0.975" "0.976" "0.972" "0.984" "1.020" "1.006" "1.007" "0.946" "0.564" "3940.8" "3843.8" "3845.7" "3831.6" "3878.7" "4017.8" "3965.1" "3967.9" "3729.7" "2221.8" "" "" "" "" "" "" "" "" "" "" "3494.7" "3184.0" "3355.6" "2865.5" "3234.3" "3690.8" "3351.1" "3279.7" "3420.6" "2221.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "170.883" "38" "14" "46" "14" "453" "48.7" "8.95" "187.36" "14" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "Citric acid cycle (TCA cycle); Lysine catabolism; Glyoxylate metabolism and glycine degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "10" "0" "1.041" "1.013" "1.045" "1.026" "1.002" "1.017" "1.011" "1.018" "0.421" "5610.0" "5840.9" "5682.3" "5861.5" "5756.7" "5623.6" "5704.0" "5669.1" "5709.8" "2360.8" "" "" "" "" "" "" "" "" "" "" "4974.8" "4838.4" "4958.1" "4383.6" "4800.3" "5165.9" "4820.8" "4685.9" "5236.7" "2360.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "170.614" "46" "17" "65" "17" "330" "37.4" "10.01" "238.64" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "0.960" "0.961" "1.004" "0.956" "0.977" "1.025" "1.073" "1.025" "0.403" "9812.9" "9416.4" "9430.0" "9854.1" "9382.6" "9591.6" "10057.6" "10524.4" "10060.3" "3953.3" "" "" "" "" "" "" "" "" "" "" "8701.9" "7800.1" "8228.1" "7369.6" "7823.8" "8810.9" "8500.3" "8699.1" "9226.6" "3953.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "170.471" "65" "16" "50" "16" "329" "35.2" "8.44" "195.77" "16" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "0.977" "1.043" "1.005" "1.024" "1.066" "1.024" "1.072" "1.005" "0.551" "4886.2" "4772.8" "5096.9" "4909.3" "5005.1" "5211.0" "5004.9" "5235.6" "4910.4" "2692.2" "" "" "" "" "" "" "" "" "" "" "4333.0" "3953.5" "4447.3" "3671.5" "4173.6" "4786.9" "4230.0" "4327.6" "4503.5" "2692.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "High" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.000" "False" "170.384" "9" "44" "48" "44" "4684" "531.5" "5.96" "155.26" "44" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "Envelope proteins and their potential roles in EDMD physiopathology" "4" "0" "1.005" "0.871" "0.952" "0.911" "0.830" "0.865" "0.609" "0.905" "4.801" "1874.2" "1882.9" "1632.2" "1784.0" "1708.0" "1554.7" "1621.9" "1142.0" "1696.5" "8998.5" "" "" "" "" "" "" "" "" "" "" "1662.0" "1559.7" "1424.2" "1334.2" "1424.3" "1428.2" "1370.8" "943.9" "1555.9" "8998.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "170.274" "63" "19" "58" "9" "318" "34.8" "6.98" "244.66" "19" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "9" "1.010" "1.021" "1.063" "1.098" "1.009" "1.075" "1.051" "0.973" "0.502" "7543.5" "7620.3" "7699.4" "8019.4" "8285.0" "7613.1" "8112.8" "7927.8" "7343.1" "3788.8" "" "" "" "" "" "" "" "" "" "" "6689.4" "6312.3" "6718.1" "5997.4" "6908.5" "6993.5" "6856.6" "6552.8" "6734.6" "3788.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "169.879" "29" "28" "47" "28" "1071" "123.3" "6.06" "179.08" "28" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "19" "0" "1.042" "0.968" "1.063" "1.016" "0.936" "1.085" "0.255" "0.970" "17.059" "1830.7" "1908.4" "1771.5" "1946.0" "1860.4" "1714.0" "1985.5" "467.1" "1776.5" "31229.6" "" "" "" "" "" "" "" "" "" "" "1623.4" "1580.8" "1545.7" "1455.4" "1551.3" "1574.5" "1678.1" "386.1" "1629.3" "31229.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "169.868" "33" "34" "47" "34" "1042" "117.7" "6.52" "171.49" "34" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "0.954" "0.951" "0.980" "0.948" "0.901" "1.004" "0.954" "0.965" "1.051" "6473.6" "6178.0" "6157.2" "6346.9" "6135.3" "5832.9" "6502.0" "6175.8" "6245.2" "6806.1" "" "" "" "" "" "" "" "" "" "" "5740.6" "5117.6" "5372.5" "4746.6" "5116.0" "5358.2" "5495.2" "5104.7" "5727.7" "6806.1" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4998173569116180962" "False" "High" "IsMasterProtein" "P12532" "Creatine kinase U-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT1B PE=1 SV=1" "0.000" "False" "169.847" "48" "20" "63" "20" "417" "47.0" "8.34" "230.82" "20" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00217, Pf02807" "1159; 548596" "ENSG00000223572; ENSG00000237289" "CKMT1A; CKMT1B" "B4DIT8; B7ZA09; hsa:1159; hsa:548596; P12532; Q0VAM3; Q32NF6; Q53FC4" "Creatine metabolism" "" "1" "0" "0.990" "0.970" "1.035" "1.014" "1.010" "1.084" "1.108" "1.112" "0.366" "6455.6" "6394.0" "6262.0" "6683.4" "6547.4" "6521.9" "6999.2" "7149.6" "7179.3" "2360.4" "" "" "" "" "" "" "" "" "" "" "5724.7" "5296.5" "5463.9" "4998.3" "5459.6" "5991.1" "5915.5" "5909.7" "6584.4" "2360.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "169.596" "55" "24" "64" "24" "389" "45.5" "5.62" "241.05" "24" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "FCERI mediated NF-kB activation; ABC-family proteins mediated transport; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neutrophil degranulation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.016" "1.077" "1.027" "1.101" "1.107" "1.097" "1.123" "1.132" "0.843" "5071.8" "5151.9" "5460.7" "5207.2" "5585.7" "5615.8" "5562.8" "5694.5" "5740.3" "4275.6" "" "" "" "" "" "" "" "" "" "" "4497.6" "4267.6" "4764.7" "3894.3" "4657.7" "5158.8" "4701.4" "4706.9" "5264.6" "4275.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "169.553" "32" "27" "45" "27" "780" "90.9" "7.94" "166.04" "27" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Downregulation of ERBB2 signaling; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "10" "0" "1.040" "1.017" "1.050" "1.056" "1.054" "1.046" "1.055" "0.967" "0.544" "6084.6" "6328.4" "6190.7" "6387.3" "6424.5" "6414.9" "6362.6" "6416.6" "5881.8" "3312.4" "" "" "" "" "" "" "" "" "" "" "5395.7" "5242.1" "5401.7" "4776.9" "5357.2" "5892.8" "5377.5" "5303.8" "5394.4" "3312.4" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "169.242" "60" "18" "35" "18" "361" "41.5" "6.60" "143.26" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "Anchoring of the basal body to the plasma membrane" "2q37 copy number variation syndrome" "2" "0" "1.020" "1.034" "1.002" "1.012" "1.050" "1.018" "1.023" "0.968" "0.553" "4676.0" "4769.8" "4833.6" "4686.6" "4733.7" "4911.6" "4762.2" "4783.6" "4526.7" "2584.2" "" "" "" "" "" "" "" "" "" "" "4146.6" "3951.0" "4217.5" "3504.9" "3947.3" "4511.8" "4024.8" "3954.0" "4151.6" "2584.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "169.069" "45" "22" "56" "22" "511" "57.2" "6.21" "209.11" "22" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "miR-517 relationship with ARCN1 and USP1" "3" "0" "1.012" "1.030" "1.011" "1.014" "1.007" "0.978" "0.999" "0.945" "1.055" "7633.9" "7727.2" "7864.1" "7718.0" "7737.3" "7687.8" "7464.0" "7626.0" "7214.5" "8051.8" "" "" "" "" "" "" "" "" "" "" "6769.6" "6400.9" "6861.8" "5772.1" "6451.9" "7062.1" "6308.2" "6303.4" "6616.7" "8051.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "168.943" "43" "15" "47" "9" "429" "49.4" "6.81" "183.73" "15" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "" "22q11.2 copy number variation syndrome" "1" "7" "0.981" "1.037" "1.035" "1.030" "1.025" "1.029" "1.067" "1.023" "0.536" "4674.4" "4585.1" "4845.9" "4838.0" "4814.6" "4789.5" "4808.4" "4988.9" "4781.0" "2505.0" "" "" "" "" "" "" "" "" "" "" "4145.1" "3798.1" "4228.3" "3618.2" "4014.7" "4399.7" "4063.9" "4123.7" "4384.8" "2505.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "168.708" "46" "19" "55" "19" "475" "53.5" "5.25" "207.37" "19" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "" "Ciliopathies" "1" "0" "1.033" "1.030" "1.070" "1.061" "1.006" "1.104" "1.041" "1.003" "1.283" "5151.6" "5323.2" "5307.1" "5512.0" "5466.0" "5181.7" "5687.2" "5364.6" "5167.9" "6610.7" "" "" "" "" "" "" "" "" "" "" "4568.3" "4409.5" "4630.7" "4122.3" "4557.9" "4760.0" "4806.6" "4434.2" "4739.7" "6610.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "168.470" "36" "22" "49" "16" "644" "70.7" "9.26" "192.82" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "1.006" "1.075" "0.926" "0.916" "0.975" "0.899" "0.864" "0.925" "2.546" "3157.8" "3176.5" "3396.2" "2924.0" "2893.1" "3077.5" "2838.2" "2728.4" "2922.2" "8041.3" "" "" "" "" "" "" "" "" "" "" "2800.3" "2631.2" "2963.3" "2186.8" "2412.5" "2827.0" "2398.7" "2255.2" "2680.0" "8041.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "168.398" "38" "14" "69" "7" "425" "47.6" "4.89" "281.85" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "RNA Polymerase I Transcription Initiation; HCMV Early Events; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "28" "0" "0.978" "0.995" "0.986" "1.011" "1.011" "1.021" "1.026" "1.003" "0.625" "7037.2" "6882.9" "7004.9" "6937.7" "7112.9" "7113.6" "7186.1" "7219.3" "7058.8" "4401.6" "" "" "" "" "" "" "" "" "" "" "6240.4" "5701.5" "6112.1" "5188.5" "5931.2" "6534.6" "6073.4" "5967.3" "6473.9" "4401.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "168.335" "41" "25" "36" "25" "740" "82.4" "7.23" "143.23" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "tRNA processing in the nucleus" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "3" "0" "0.984" "0.935" "0.897" "0.858" "0.880" "0.861" "0.810" "0.899" "2.042" "2894.2" "2848.3" "2705.2" "2596.1" "2482.7" "2546.3" "2491.2" "2343.5" "2600.9" "5908.8" "" "" "" "" "" "" "" "" "" "" "2566.6" "2359.4" "2360.4" "1941.5" "2070.3" "2339.1" "2105.5" "1937.0" "2385.4" "5908.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "168.222" "41" "23" "57" "23" "546" "61.9" "6.52" "226.64" "23" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "Other interleukin signaling" "" "1" "0" "0.966" "0.945" "0.950" "0.920" "0.989" "0.940" "0.945" "0.960" "0.670" "6520.6" "6301.9" "6160.2" "6194.6" "5997.9" "6451.8" "6131.2" "6163.1" "6262.4" "4369.7" "" "" "" "" "" "" "" "" "" "" "5782.4" "5220.2" "5375.1" "4632.7" "5001.4" "5926.7" "5181.8" "5094.2" "5743.5" "4369.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "168.133" "34" "14" "25" "14" "545" "61.3" "7.17" "118.69" "14" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "0.983" "0.971" "0.998" "0.955" "1.011" "0.924" "0.920" "0.897" "0.517" "2688.2" "2642.4" "2609.8" "2683.6" "2568.3" "2716.7" "2483.9" "2473.2" "2411.1" "1390.1" "" "" "" "" "" "" "" "" "" "" "2383.9" "2188.9" "2277.2" "2007.0" "2141.7" "2495.6" "2099.3" "2044.3" "2211.3" "1390.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "167.842" "54" "15" "54" "15" "357" "38.3" "7.97" "217.74" "15" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "Disorders of fructose metabolism; Polyol pathway" "4" "0" "1.017" "1.023" "1.028" "1.055" "1.045" "1.034" "1.039" "1.050" "0.516" "6678.4" "6789.2" "6833.9" "6862.6" "7045.3" "6981.7" "6902.5" "6941.2" "7015.6" "3448.8" "" "" "" "" "" "" "" "" "" "" "5922.2" "5623.8" "5962.9" "5132.3" "5874.8" "6413.4" "5833.7" "5737.4" "6434.2" "3448.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "167.781" "58" "18" "51" "8" "318" "34.7" "6.61" "194.89" "18" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "0" "1.036" "1.051" "1.074" "1.144" "1.034" "1.112" "1.076" "0.972" "0.506" "3007.8" "3116.9" "3162.4" "3231.3" "3441.5" "3110.1" "3344.5" "3237.7" "2923.8" "1523.4" "" "" "" "" "" "" "" "" "" "" "2667.3" "2581.9" "2759.3" "2416.5" "2869.7" "2857.0" "2826.7" "2676.2" "2681.5" "1523.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "167.294" "41" "19" "63" "19" "537" "60.1" "5.85" "247.27" "19" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "" "2" "0" "0.950" "0.930" "1.010" "0.997" "1.068" "1.026" "1.026" "1.010" "1.278" "6246.9" "5936.3" "5810.6" "6312.4" "6226.8" "6670.1" "6411.8" "6407.8" "6307.5" "7985.4" "" "" "" "" "" "" "" "" "" "" "5539.6" "4917.3" "5070.0" "4720.8" "5192.3" "6127.3" "5419.0" "5296.5" "5784.8" "7985.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5394846730023349610" "False" "High" "IsMasterProtein" "P55081" "Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2" "0.000" "False" "167.290" "39" "14" "36" "12" "439" "51.9" "4.98" "157.58" "14" "RNA metabolism OR transcription;other metabolic processes" "extracellular matrix;cytoskeleton;nucleus" "" "Pf06991" "4236" "ENSG00000140259" "MFAP1" "hsa:4236; P55081; Q86TG6" "mRNA Splicing - Major Pathway" "Canonical and non-canonical Notch signaling; Ciliary landscape" "3" "2" "0.985" "0.945" "0.942" "0.980" "1.004" "0.892" "0.973" "0.966" "0.267" "3248.3" "3200.6" "3069.3" "3058.8" "3182.7" "3262.6" "2898.2" "3162.1" "3137.6" "868.2" "" "" "" "" "" "" "" "" "" "" "2880.5" "2651.2" "2678.1" "2287.6" "2654.0" "2997.0" "2449.5" "2613.7" "2877.6" "868.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "167.081" "62" "16" "66" "16" "328" "37.1" "6.84" "259.59" "16" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "12" "0" "1.026" "1.076" "1.003" "1.062" "1.025" "1.026" "1.024" "1.065" "0.672" "5720.8" "5867.8" "6156.1" "5739.2" "6076.0" "5862.4" "5866.9" "5856.7" "6095.2" "3846.7" "" "" "" "" "" "" "" "" "" "" "5073.1" "4860.6" "5371.5" "4292.1" "5066.6" "5385.3" "4958.5" "4841.0" "5590.1" "3846.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "167.002" "56" "19" "56" "18" "394" "43.8" "6.55" "203.61" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "Neutrophil degranulation" "" "1" "0" "0.941" "0.930" "0.912" "0.940" "1.015" "0.986" "0.915" "0.914" "1.331" "7659.6" "7211.3" "7122.6" "6982.6" "7200.8" "7774.4" "7553.8" "7010.4" "7003.2" "10197.6" "" "" "" "" "" "" "" "" "" "" "6792.3" "5973.5" "6214.8" "5222.1" "6004.5" "7141.6" "6384.1" "5794.6" "6422.9" "10197.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "166.896" "19" "37" "44" "37" "2032" "225.4" "7.80" "154.16" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "4p16.3 copy number variation" "14" "0" "1.002" "0.941" "0.987" "0.942" "0.982" "0.995" "0.574" "0.971" "7.793" "2143.9" "2148.2" "2018.1" "2115.4" "2019.0" "2106.3" "2132.9" "1231.5" "2082.7" "16708.5" "" "" "" "" "" "" "" "" "" "" "1901.2" "1779.5" "1760.9" "1582.1" "1683.6" "1934.9" "1802.7" "1017.9" "1910.2" "16708.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "166.755" "28" "22" "42" "22" "833" "95.3" "4.94" "153.29" "22" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "" "16p11.2 proximal deletion syndrome" "1" "0" "1.014" "1.023" "1.024" "1.028" "1.010" "0.978" "0.968" "0.912" "0.879" "4098.3" "4155.2" "4193.3" "4198.0" "4213.0" "4137.6" "4007.9" "3965.8" "3737.3" "3602.3" "" "" "" "" "" "" "" "" "" "" "3634.3" "3442.0" "3658.9" "3139.5" "3513.1" "3800.9" "3387.3" "3278.0" "3427.6" "3602.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "166.560" "75" "12" "57" "12" "218" "24.6" "6.68" "211.71" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "Mesodermal commitment pathway" "4" "0" "1.024" "1.028" "1.052" "1.069" "1.064" "1.044" "1.088" "1.007" "0.488" "6369.6" "6521.5" "6547.3" "6703.3" "6812.0" "6775.8" "6648.9" "6929.9" "6412.1" "3111.5" "" "" "" "" "" "" "" "" "" "" "5648.4" "5402.1" "5712.8" "5013.2" "5680.3" "6224.4" "5619.4" "5728.1" "5880.8" "3111.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "166.527" "47" "28" "38" "28" "704" "77.7" "7.08" "140.05" "28" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "1.090" "1.042" "0.917" "1.129" "0.908" "1.083" "1.171" "1.052" "0.579" "4101.8" "4470.0" "4275.6" "3760.2" "4632.3" "3723.9" "4440.8" "4801.5" "4317.1" "2374.4" "" "" "" "" "" "" "" "" "" "" "3637.4" "3702.7" "3730.7" "2812.1" "3862.7" "3420.8" "3753.2" "3968.7" "3959.4" "2374.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8172346971524846949" "False" "High" "IsMasterProtein" "Q13126" "S-methyl-5'-thioadenosine phosphorylase OS=Homo sapiens OX=9606 GN=MTAP PE=1 SV=2" "0.000" "False" "166.238" "70" "16" "48" "16" "283" "31.2" "7.18" "186.97" "16" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01048" "4507" "ENSG00000099810" "MTAP" "hsa:4507; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0; Q13126; Q5T3P3; Q9H010" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Methionine salvage pathway" "Methionine de novo and salvage pathway" "3" "0" "1.037" "1.046" "1.025" "1.049" "1.061" "1.017" "1.005" "0.966" "0.517" "3364.6" "3489.7" "3520.0" "3449.3" "3530.5" "3569.6" "3421.6" "3381.9" "3250.9" "1740.5" "" "" "" "" "" "" "" "" "" "" "2983.6" "2890.7" "3071.4" "2579.7" "2944.0" "3279.0" "2891.8" "2795.4" "2981.5" "1740.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "166.073" "81" "20" "149" "14" "166" "18.5" "8.09" "588.27" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "15" "7" "0.974" "1.038" "0.928" "0.951" "1.049" "0.873" "0.951" "1.005" "0.574" "22233.2" "21659.7" "23084.9" "20630.3" "21151.2" "23311.7" "19415.2" "21153.1" "22346.1" "12768.3" "" "" "" "" "" "" "" "" "" "" "19715.9" "17941.8" "20142.7" "15428.7" "17637.2" "21414.4" "16409.0" "17484.5" "20494.4" "12768.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "165.970" "36" "28" "34" "28" "1024" "114.6" "9.22" "147.15" "28" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "tRNA processing in the nucleus" "" "1" "0" "0.932" "0.924" "0.991" "0.958" "0.950" "0.867" "0.917" "0.896" "0.545" "2494.1" "2324.2" "2303.6" "2471.5" "2389.0" "2368.4" "2161.8" "2285.9" "2234.5" "1358.5" "" "" "" "" "" "" "" "" "" "" "2211.7" "1925.3" "2010.0" "1848.4" "1992.1" "2175.6" "1827.1" "1889.4" "2049.3" "1358.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "165.822" "64" "16" "208" "9" "247" "28.3" "4.89" "623.14" "16" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "22" "5" "1.040" "1.086" "0.973" "1.109" "0.992" "0.953" "1.011" "1.006" "0.581" "12809.4" "13326.4" "13911.1" "12468.5" "14203.3" "12710.7" "12206.8" "12944.9" "12886.6" "7445.2" "" "" "" "" "" "" "" "" "" "" "11359.1" "11039.0" "12138.1" "9324.8" "11843.6" "11676.2" "10316.7" "10699.9" "11818.8" "7445.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "165.292" "36" "22" "36" "22" "747" "86.1" "6.62" "147.06" "22" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "Synthesis of PIPs at the early endosome membrane" "" "1" "0" "1.021" "1.037" "1.010" "1.052" "1.050" "0.974" "1.021" "0.997" "0.581" "3360.5" "3432.4" "3484.4" "3394.8" "3535.4" "3530.0" "3273.2" "3431.8" "3351.7" "1952.4" "" "" "" "" "" "" "" "" "" "" "2980.0" "2843.2" "3040.3" "2538.9" "2948.0" "3242.7" "2766.4" "2836.7" "3074.0" "1952.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "165.238" "40" "21" "62" "21" "564" "66.7" "6.34" "239.70" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "0.983" "1.013" "0.986" "0.995" "0.980" "1.020" "1.036" "0.986" "0.512" "6749.2" "6632.3" "6834.2" "6657.0" "6715.5" "6612.4" "6886.3" "6990.3" "6652.7" "3457.9" "" "" "" "" "" "" "" "" "" "" "5985.1" "5493.9" "5963.2" "4978.5" "5599.8" "6074.2" "5820.0" "5778.0" "6101.5" "3457.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3295496481374294049" "False" "High" "IsMasterProtein" "Q9UHD9" "Ubiquilin-2 OS=Homo sapiens OX=9606 GN=UBQLN2 PE=1 SV=2" "0.000" "False" "164.690" "25" "11" "53" "5" "624" "65.7" "5.22" "227.28" "11" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29978" "ENSG00000188021" "UBQLN2" "hsa:29978; O94798; Q5D027; Q9H3W6; Q9HAZ4; Q9UHD9" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "4" "1.037" "0.986" "1.039" "1.054" "0.998" "1.014" "0.997" "1.034" "0.616" "2485.2" "2576.2" "2450.4" "2581.7" "2620.3" "2480.3" "2520.5" "2478.3" "2570.7" "1530.0" "" "" "" "" "" "" "" "" "" "" "2203.8" "2134.0" "2138.1" "1930.7" "2184.9" "2278.5" "2130.2" "2048.5" "2357.7" "1530.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "164.464" "42" "12" "45" "12" "377" "40.7" "4.79" "197.02" "12" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "64" "0" "0.992" "1.033" "1.052" "1.041" "1.018" "1.085" "1.088" "1.057" "0.577" "5475.5" "5431.7" "5657.9" "5758.9" "5698.9" "5573.2" "5939.1" "5957.6" "5788.6" "3160.2" "" "" "" "" "" "" "" "" "" "" "4855.6" "4499.3" "4936.8" "4306.9" "4752.1" "5119.6" "5019.4" "4924.4" "5308.9" "3160.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "164.428" "47" "25" "43" "25" "593" "68.0" "7.30" "170.45" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "PIP3 activates AKT signaling; GPVI-mediated activation cascade; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PD-1 signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; PI3K Cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; Platelet sensitization by LDL; PECAM1 interactions; CTLA4 inhibitory signaling; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "91" "0" "1.018" "1.036" "0.962" "1.024" "1.040" "0.952" "1.012" "0.987" "0.686" "4713.8" "4797.4" "4883.2" "4533.7" "4828.8" "4903.2" "4487.4" "4769.4" "4652.3" "3232.7" "" "" "" "" "" "" "" "" "" "" "4180.1" "3973.9" "4260.8" "3390.6" "4026.6" "4504.1" "3792.6" "3942.3" "4266.8" "3232.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "164.171" "42" "17" "81" "17" "378" "44.4" "5.25" "286.43" "17" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RHOBTB2 GTPase cycle; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "27" "0" "0.958" "0.959" "0.915" "0.923" "0.955" "0.945" "0.994" "1.010" "0.583" "12159.6" "11644.9" "11661.8" "11129.5" "11220.2" "11614.2" "11492.6" "12084.9" "12278.9" "7083.0" "" "" "" "" "" "" "" "" "" "" "10782.9" "9646.1" "10175.5" "8323.4" "9356.1" "10668.9" "9713.1" "9989.0" "11261.4" "7083.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-566189082840404496" "False" "High" "IsMasterProtein" "Q8WVM7" "Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3" "0.000" "False" "164.135" "24" "30" "42" "21" "1258" "144.3" "5.59" "155.10" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10274" "ENSG00000118007" "STAG1" "hsa:10274; O00539; Q6P275; Q8WVM7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Estrogen-dependent gene expression; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "10" "0" "1.044" "1.018" "1.005" "1.057" "1.001" "0.962" "0.946" "0.968" "0.770" "1515.9" "1582.5" "1543.8" "1522.9" "1601.9" "1517.4" "1457.9" "1433.5" "1467.6" "1167.9" "" "" "" "" "" "" "" "" "" "" "1344.3" "1310.9" "1347.0" "1138.9" "1335.7" "1393.9" "1232.2" "1184.9" "1346.0" "1167.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "164.131" "56" "13" "97" "13" "252" "26.5" "9.36" "393.27" "13" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "" "Pyrimidine metabolism" "1" "0" "1.016" "0.980" "0.969" "0.960" "1.134" "1.046" "1.010" "1.063" "0.687" "7429.9" "7546.1" "7278.2" "7202.2" "7135.4" "8421.8" "7772.6" "7506.8" "7899.0" "5103.0" "" "" "" "" "" "" "" "" "" "" "6588.7" "6250.8" "6350.6" "5386.3" "5950.0" "7736.4" "6569.1" "6204.9" "7244.5" "5103.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3497794903438612376" "False" "High" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "0.000" "False" "163.875" "36" "25" "52" "25" "710" "80.3" "8.15" "183.53" "25" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins" "Endoderm differentiation" "5" "0" "0.975" "0.953" "0.964" "0.920" "0.926" "0.886" "0.875" "0.923" "1.343" "6296.9" "6140.4" "6002.5" "6072.1" "5790.3" "5829.7" "5580.0" "5508.7" "5811.7" "8459.3" "" "" "" "" "" "" "" "" "" "" "5583.9" "5086.4" "5237.5" "4541.2" "4828.3" "5355.2" "4716.0" "4553.4" "5330.1" "8459.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "163.860" "41" "17" "53" "17" "421" "46.6" "8.37" "208.13" "17" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "0.999" "1.038" "0.991" "1.015" "1.063" "1.040" "1.071" "1.050" "0.503" "6025.6" "6021.2" "6253.9" "5972.0" "6117.7" "6403.3" "6267.7" "6454.9" "6329.6" "3029.1" "" "" "" "" "" "" "" "" "" "" "5343.4" "4987.7" "5456.9" "4466.3" "5101.3" "5882.2" "5297.2" "5335.4" "5805.1" "3029.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "163.835" "25" "33" "41" "33" "1394" "157.8" "6.13" "141.24" "33" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "Ciliary landscape" "5" "0" "1.045" "0.974" "1.176" "1.067" "0.998" "1.048" "0.327" "1.017" "18.682" "1362.6" "1424.0" "1326.9" "1601.8" "1454.0" "1360.0" "1427.8" "445.2" "1385.8" "25456.5" "" "" "" "" "" "" "" "" "" "" "1208.3" "1179.5" "1157.8" "1198.0" "1212.4" "1249.3" "1206.7" "368.0" "1271.0" "25456.5" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "163.646" "45" "27" "39" "27" "767" "86.4" "6.77" "161.79" "27" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.052" "0.958" "1.075" "0.997" "0.889" "0.995" "0.573" "0.845" "8.032" "2186.0" "2300.4" "2093.8" "2350.9" "2178.4" "1942.6" "2175.1" "1253.5" "1846.8" "17558.6" "" "" "" "" "" "" "" "" "" "" "1938.5" "1905.5" "1827.0" "1758.2" "1816.5" "1784.5" "1838.3" "1036.1" "1693.8" "17558.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4038126070754837566" "False" "High" "IsMasterProtein" "Cont_Q3SYV4" "Adenylyl cyclase-associated protein 1 OS=Bos taurus OX=9913 GN=CAP1 PE=2 SV=3" "0.000" "True" "163.166" "33" "15" "94" "1" "472" "51.2" "7.52" "344.41" "15" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "109556455; 504519" "" "CAP1" "A0A6P5BIK1; biu:109556455; bta:504519; Q3SYV4" "" "" "0" "0" "1.021" "1.053" "1.104" "1.075" "0.933" "1.106" "1.061" "0.977" "0.609" "561.9" "573.8" "591.9" "620.5" "604.3" "524.4" "621.7" "596.4" "548.9" "342.4" "" "" "" "" "" "" "" "" "" "" "498.3" "475.3" "516.5" "464.0" "503.9" "481.8" "525.4" "493.0" "503.4" "342.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "163.038" "41" "23" "41" "23" "633" "69.2" "7.58" "163.51" "23" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "Mitochondrial protein degradation" "" "1" "0" "1.026" "1.046" "1.146" "1.149" "1.025" "1.185" "1.291" "1.259" "0.833" "4821.0" "4946.7" "5042.0" "5526.2" "5537.6" "4939.1" "5714.2" "6225.7" "6070.8" "4015.8" "" "" "" "" "" "" "" "" "" "" "4275.1" "4097.6" "4399.4" "4132.8" "4617.6" "4537.1" "4829.4" "5146.0" "5567.8" "4015.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "163.020" "16" "34" "37" "33" "2602" "278.0" "5.73" "138.48" "34" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "ISG15 antiviral mechanism" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "6" "1" "0.968" "1.000" "0.999" "0.960" "0.985" "1.006" "0.985" "0.985" "1.150" "3297.1" "3192.4" "3295.8" "3294.2" "3163.6" "3246.6" "3317.6" "3248.2" "3249.3" "3791.8" "" "" "" "" "" "" "" "" "" "" "2923.8" "2644.4" "2875.8" "2463.6" "2638.0" "2982.3" "2803.9" "2684.9" "2980.0" "3791.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "162.758" "33" "20" "49" "20" "708" "76.5" "5.07" "200.87" "20" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "" "2" "0" "0.999" "0.993" "0.979" "0.959" "0.879" "0.895" "0.982" "1.021" "0.527" "4472.7" "4467.8" "4442.4" "4378.3" "4289.3" "3933.2" "4002.5" "4392.0" "4565.1" "2357.9" "" "" "" "" "" "" "" "" "" "" "3966.3" "3700.9" "3876.2" "3274.4" "3576.7" "3613.0" "3382.8" "3630.3" "4186.8" "2357.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "162.729" "37" "17" "48" "10" "577" "60.9" "6.83" "180.54" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "6" "1.040" "1.005" "1.028" "1.023" "1.004" "1.031" "1.046" "1.038" "0.610" "5543.0" "5762.1" "5568.2" "5697.5" "5670.6" "5564.1" "5715.0" "5796.5" "5755.2" "3380.2" "" "" "" "" "" "" "" "" "" "" "4915.4" "4773.1" "4858.5" "4260.9" "4728.5" "5111.3" "4830.1" "4791.2" "5278.3" "3380.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "162.727" "51" "20" "38" "20" "450" "50.7" "7.06" "133.40" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Signaling by BRAF and RAF1 fusions; Negative regulation of FLT3; GAB1 signalosome; Integrin signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; RHOH GTPase cycle; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "18" "0" "0.997" "1.009" "1.087" "1.026" "1.003" "0.965" "0.837" "0.981" "4.307" "2573.5" "2566.2" "2596.9" "2798.3" "2639.4" "2581.3" "2484.3" "2153.6" "2525.7" "11083.6" "" "" "" "" "" "" "" "" "" "" "2282.1" "2125.7" "2266.0" "2092.8" "2200.9" "2371.2" "2099.6" "1780.1" "2316.4" "11083.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "162.623" "56" "12" "60" "12" "261" "29.5" "7.72" "273.03" "12" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "63" "0" "0.977" "0.983" "0.950" "0.968" "0.966" "0.926" "0.968" "0.918" "0.509" "8056.0" "7869.5" "7919.7" "7651.4" "7797.3" "7780.3" "7463.1" "7796.6" "7394.5" "4099.6" "" "" "" "" "" "" "" "" "" "" "7143.9" "6518.7" "6910.3" "5722.2" "6501.9" "7147.0" "6307.5" "6444.4" "6781.7" "4099.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "162.583" "71" "13" "49" "12" "215" "23.9" "6.21" "179.53" "13" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "7" "0" "1.040" "1.059" "1.057" "1.082" "1.053" "1.017" "1.026" "0.941" "0.469" "4187.9" "4354.3" "4435.9" "4427.8" "4533.0" "4411.3" "4258.6" "4296.8" "3942.1" "1966.0" "" "" "" "" "" "" "" "" "" "" "3713.8" "3606.9" "3870.5" "3311.4" "3779.9" "4052.3" "3599.2" "3551.6" "3615.5" "1966.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "162.553" "30" "28" "39" "28" "1014" "113.0" "8.88" "145.14" "28" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "SUMOylation of DNA damage response and repair proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "25" "0" "1.057" "0.982" "1.081" "0.993" "0.967" "0.969" "0.571" "1.015" "8.772" "2690.1" "2844.4" "2642.7" "2907.2" "2672.4" "2602.0" "2607.5" "1536.1" "2731.3" "23598.6" "" "" "" "" "" "" "" "" "" "" "2385.5" "2356.2" "2305.9" "2174.2" "2228.4" "2390.2" "2203.7" "1269.7" "2505.0" "23598.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "162.354" "47" "21" "36" "21" "527" "59.7" "7.39" "143.66" "21" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "12" "0" "0.990" "0.986" "1.041" "0.986" "1.027" "1.003" "0.999" "0.961" "0.526" "4010.2" "3972.1" "3954.4" "4173.2" "3954.9" "4119.3" "4024.1" "4006.7" "3853.5" "2110.9" "" "" "" "" "" "" "" "" "" "" "3556.2" "3290.3" "3450.4" "3121.0" "3297.9" "3784.0" "3401.0" "3311.8" "3534.2" "2110.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "162.341" "36" "22" "38" "22" "747" "85.1" "4.91" "151.22" "22" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "0.979" "0.948" "1.136" "1.061" "1.127" "1.602" "1.360" "1.571" "4.958" "2019.3" "1977.4" "1914.5" "2293.7" "2142.7" "2275.1" "3234.8" "2745.6" "3172.0" "10011.3" "" "" "" "" "" "" "" "" "" "" "1790.7" "1638.0" "1670.5" "1715.4" "1786.8" "2090.0" "2733.9" "2269.4" "2909.2" "10011.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "162.127" "41" "14" "58" "14" "394" "44.7" "6.74" "210.31" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "8" "0" "0.995" "1.007" "1.021" "1.022" "1.067" "1.006" "1.031" "0.969" "0.540" "5060.0" "5033.9" "5097.4" "5165.6" "5170.4" "5400.5" "5088.7" "5218.0" "4902.8" "2734.1" "" "" "" "" "" "" "" "" "" "" "4487.1" "4169.9" "4447.7" "3863.2" "4311.4" "4961.0" "4300.8" "4313.0" "4496.5" "2734.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "162.031" "49" "15" "90" "15" "272" "30.6" "6.00" "315.94" "15" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "VEGFA-VEGFR2 signaling" "9" "0" "1.019" "1.060" "1.035" "1.046" "1.058" "1.065" "1.099" "1.035" "0.599" "10896.8" "11101.1" "11549.0" "11281.7" "11398.4" "11531.8" "11609.3" "11970.7" "11277.1" "6522.8" "" "" "" "" "" "" "" "" "" "" "9663.0" "9195.6" "10077.0" "8437.2" "9504.8" "10593.2" "9811.7" "9894.6" "10342.7" "6522.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "162.022" "55" "12" "44" "12" "253" "28.8" "5.59" "191.82" "12" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "1.027" "1.058" "1.079" "1.077" "1.082" "1.042" "1.017" "1.044" "1.130" "4805.7" "4937.5" "5085.1" "5184.1" "5178.1" "5197.4" "5008.1" "4889.7" "5017.1" "5430.5" "" "" "" "" "" "" "" "" "" "" "4261.6" "4090.0" "4437.0" "3877.0" "4317.8" "4774.4" "4232.6" "4041.7" "4601.4" "5430.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "161.903" "29" "26" "40" "25" "1008" "114.7" "7.68" "149.63" "26" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "VEGFA-VEGFR2 signaling" "2" "1" "0.987" "0.964" "1.004" "0.969" "1.000" "0.992" "0.985" "0.954" "1.115" "2986.2" "2946.0" "2878.4" "2999.1" "2892.5" "2985.2" "2962.9" "2942.2" "2848.3" "3330.6" "" "" "" "" "" "" "" "" "" "" "2648.1" "2440.4" "2511.6" "2242.9" "2411.9" "2742.3" "2504.1" "2431.9" "2612.3" "3330.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "161.760" "25" "27" "34" "27" "1321" "146.1" "5.15" "140.43" "27" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "Myogenesis" "" "1" "0" "1.001" "0.953" "0.948" "0.964" "0.980" "0.976" "0.889" "0.982" "2.744" "3830.1" "3832.9" "3651.6" "3629.9" "3691.7" "3752.8" "3736.4" "3404.9" "3759.5" "10511.8" "" "" "" "" "" "" "" "" "" "" "3396.5" "3175.0" "3186.2" "2714.7" "3078.4" "3447.4" "3157.9" "2814.4" "3448.0" "10511.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "161.634" "45" "23" "40" "23" "626" "72.2" "7.14" "158.18" "23" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "Interferon alpha/beta signaling; Nucleotide catabolism" "" "2" "0" "1.005" "1.004" "0.990" "1.003" "0.987" "1.054" "1.034" "0.991" "0.838" "3919.1" "3937.0" "3936.4" "3878.6" "3931.5" "3867.8" "4131.2" "4051.4" "3882.1" "3283.6" "" "" "" "" "" "" "" "" "" "" "3475.4" "3261.2" "3434.7" "2900.7" "3278.3" "3553.0" "3491.5" "3348.8" "3560.4" "3283.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "161.608" "41" "26" "33" "26" "745" "82.8" "7.37" "125.53" "26" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "0.963" "0.965" "1.012" "1.000" "0.968" "1.117" "1.170" "1.116" "0.843" "2313.9" "2228.4" "2233.0" "2341.5" "2312.8" "2240.2" "2584.9" "2706.2" "2582.6" "1951.1" "" "" "" "" "" "" "" "" "" "" "2051.9" "1845.9" "1948.4" "1751.1" "1928.6" "2057.8" "2184.6" "2236.9" "2368.6" "1951.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "161.549" "47" "14" "43" "6" "365" "38.6" "6.79" "159.50" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1 activates/modulates innate immune responses" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "7" "1" "1.066" "1.036" "1.062" "1.053" "0.983" "1.065" "0.727" "0.968" "6.719" "1638.7" "1746.5" "1698.3" "1740.9" "1725.9" "1611.6" "1744.8" "1190.6" "1586.8" "11010.5" "" "" "" "" "" "" "" "" "" "" "1453.2" "1446.7" "1481.9" "1301.9" "1439.2" "1480.4" "1474.7" "984.1" "1455.3" "11010.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "161.243" "76" "12" "48" "9" "216" "23.5" "8.41" "207.51" "12" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "10" "4" "1.076" "1.091" "1.071" "1.097" "1.022" "1.067" "1.064" "1.038" "0.598" "4285.8" "4610.8" "4676.6" "4589.0" "4700.9" "4380.0" "4571.4" "4558.6" "4447.8" "2565.0" "" "" "" "" "" "" "" "" "" "" "3800.6" "3819.3" "4080.6" "3432.0" "3919.9" "4023.6" "3863.6" "3768.0" "4079.3" "2565.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "161.234" "56" "14" "51" "14" "258" "29.0" "4.83" "210.73" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.932" "0.952" "0.946" "0.906" "0.904" "0.924" "0.941" "0.933" "0.449" "8983.5" "8369.8" "8550.4" "8500.0" "8137.3" "8123.3" "8304.7" "8452.9" "8379.1" "4034.1" "" "" "" "" "" "" "" "" "" "" "7966.3" "6933.1" "7460.6" "6356.9" "6785.4" "7462.2" "7018.8" "6986.9" "7684.8" "4034.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387303708123169852" "False" "High" "IsMasterProtein" "P07602" "Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2" "0.000" "False" "161.101" "36" "17" "57" "17" "524" "58.1" "5.17" "202.65" "17" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02199, Pf03489, Pf05184" "5660" "ENSG00000197746" "PSAP" "hsa:5660; P07292; P07602; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742" "Neutrophil degranulation; G alpha (i) signalling events; Platelet degranulation ; Peptide ligand-binding receptors; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases" "6" "0" "0.963" "0.990" "0.962" "0.975" "0.998" "1.000" "1.025" "1.046" "0.498" "8379.7" "8066.2" "8294.7" "8060.4" "8167.2" "8363.7" "8377.5" "8592.5" "8766.6" "4176.7" "" "" "" "" "" "" "" "" "" "" "7430.9" "6681.6" "7237.5" "6028.1" "6810.4" "7683.0" "7080.3" "7102.3" "8040.2" "4176.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "161.063" "50" "17" "41" "17" "370" "40.4" "7.66" "158.65" "17" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "7" "0" "1.011" "1.077" "0.981" "1.028" "1.076" "1.015" "1.075" "1.059" "0.472" "4750.0" "4803.6" "5114.4" "4659.7" "4883.5" "5112.8" "4822.0" "5107.2" "5029.0" "2241.5" "" "" "" "" "" "" "" "" "" "" "4212.2" "3979.0" "4462.6" "3484.8" "4072.2" "4696.6" "4075.4" "4221.5" "4612.3" "2241.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "160.804" "31" "22" "38" "22" "790" "91.8" "6.43" "139.69" "22" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "Regulation of expression of SLITs and ROBOs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Processing of Intronless Pre-mRNAs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "0.998" "0.974" "0.988" "0.971" "0.989" "0.965" "0.993" "0.886" "1.029" "4204.2" "4196.3" "4093.4" "4155.8" "4081.4" "4157.3" "4058.3" "4176.1" "3724.1" "4326.6" "" "" "" "" "" "" "" "" "" "" "3728.2" "3476.0" "3571.7" "3108.0" "3403.3" "3818.9" "3429.9" "3451.8" "3415.5" "4326.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "160.693" "39" "20" "45" "20" "525" "58.2" "6.92" "176.88" "20" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "" "3" "0" "0.975" "0.989" "1.014" "1.015" "0.974" "1.112" "1.107" "1.016" "0.876" "3438.2" "3351.2" "3401.8" "3485.6" "3489.8" "3349.1" "3821.9" "3805.2" "3494.4" "3011.8" "" "" "" "" "" "" "" "" "" "" "3048.9" "2776.0" "2968.2" "2606.8" "2910.0" "3076.5" "3230.1" "3145.3" "3204.8" "3011.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "160.630" "67" "12" "68" "6" "181" "20.6" "7.43" "263.95" "12" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "" "3" "5" "1.011" "1.008" "1.066" "1.075" "1.014" "1.062" "1.042" "0.931" "0.536" "8395.9" "8489.0" "8460.3" "8954.2" "9022.2" "8514.5" "8916.8" "8745.8" "7818.5" "4503.9" "" "" "" "" "" "" "" "" "" "" "7445.3" "7031.9" "7382.1" "6696.5" "7523.3" "7821.5" "7536.2" "7229.0" "7170.6" "4503.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "160.569" "41" "17" "58" "17" "496" "56.8" "7.80" "198.53" "17" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "" "3" "0" "0.965" "0.937" "0.959" "0.948" "0.988" "1.010" "1.011" "0.977" "0.697" "8012.3" "7733.4" "7506.8" "7683.7" "7599.6" "7912.5" "8090.9" "8100.6" "7830.0" "5586.3" "" "" "" "" "" "" "" "" "" "" "7105.1" "6406.0" "6550.0" "5746.4" "6337.0" "7268.5" "6838.1" "6695.7" "7181.2" "5586.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "160.556" "22" "24" "43" "24" "1176" "134.4" "7.30" "142.58" "24" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "1.020" "0.977" "1.094" "1.013" "0.968" "1.290" "0.611" "1.249" "11.264" "1771.0" "1806.4" "1730.8" "1936.8" "1793.8" "1715.1" "2284.0" "1082.6" "2212.0" "19947.8" "" "" "" "" "" "" "" "" "" "" "1570.5" "1496.3" "1510.2" "1448.5" "1495.8" "1575.5" "1930.4" "894.8" "2028.8" "19947.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "160.419" "44" "19" "68" "19" "408" "46.8" "7.12" "234.44" "19" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "" "2" "0" "1.065" "1.029" "1.015" "0.989" "0.976" "0.780" "0.759" "0.759" "1.261" "8971.1" "9552.5" "9229.1" "9107.0" "8876.5" "8754.6" "6998.3" "6809.5" "6811.6" "11315.1" "" "" "" "" "" "" "" "" "" "" "7955.4" "7912.9" "8052.8" "6810.8" "7401.8" "8042.1" "5914.7" "5628.5" "6247.2" "11315.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "160.339" "54" "19" "65" "19" "300" "34.3" "7.36" "225.79" "19" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "0.981" "0.994" "1.024" "1.025" "1.010" "0.966" "1.051" "0.930" "0.500" "8702.5" "8536.4" "8648.1" "8907.4" "8923.8" "8792.6" "8404.5" "9142.8" "8096.9" "4348.9" "" "" "" "" "" "" "" "" "" "" "7717.2" "7071.1" "7545.9" "6661.6" "7441.2" "8077.0" "7103.1" "7557.2" "7426.0" "4348.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "160.249" "52" "16" "40" "15" "372" "40.9" "8.35" "183.30" "16" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "6" "1" "1.025" "1.089" "1.039" "1.098" "1.064" "1.068" "1.083" "1.046" "0.576" "5587.2" "5729.3" "6085.4" "5806.3" "6135.8" "5945.5" "5966.1" "6052.5" "5845.7" "3218.7" "" "" "" "" "" "" "" "" "" "" "4954.6" "4745.9" "5309.8" "4342.4" "5116.4" "5461.6" "5042.3" "5002.8" "5361.3" "3218.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "159.769" "52" "17" "30" "11" "514" "55.6" "5.55" "146.37" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "HCMV Early Events; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "Rett syndrome" "20" "6" "1.014" "1.016" "0.996" "1.006" "1.017" "0.970" "0.966" "0.949" "0.788" "3739.2" "3792.1" "3798.9" "3722.6" "3759.8" "3801.5" "3626.2" "3610.6" "3548.8" "2946.1" "" "" "" "" "" "" "" "" "" "" "3315.8" "3141.2" "3314.8" "2784.0" "3135.1" "3492.1" "3064.7" "2984.4" "3254.7" "2946.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5003304044033613110" "False" "High" "IsMasterProtein" "O43175" "D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4" "0.000" "False" "159.604" "36" "17" "30" "17" "533" "56.6" "6.71" "131.88" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00389, Pf02826, Pf19304" "26227" "ENSG00000092621" "PHGDH" "B2RD08; hsa:26227; O43175; Q5SZU3; Q9BQ01" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "5" "0" "1.059" "1.053" "1.147" "1.082" "1.055" "1.103" "1.072" "1.006" "0.544" "3158.8" "3344.9" "3326.2" "3622.4" "3419.3" "3333.4" "3483.8" "3386.5" "3177.5" "1718.3" "" "" "" "" "" "" "" "" "" "" "2801.2" "2770.7" "2902.3" "2709.0" "2851.2" "3062.1" "2944.4" "2799.2" "2914.2" "1718.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "159.563" "54" "16" "53" "16" "366" "41.2" "5.02" "193.32" "16" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Metabolism of polyamines" "Methionine de novo and salvage pathway; Amino acid metabolism" "3" "0" "1.050" "1.046" "1.045" "1.098" "1.119" "1.022" "1.131" "1.024" "0.559" "3983.6" "4181.7" "4165.5" "4162.9" "4375.4" "4456.8" "4073.1" "4506.7" "4077.3" "2228.1" "" "" "" "" "" "" "" "" "" "" "3532.6" "3463.9" "3634.6" "3113.3" "3648.4" "4094.0" "3442.5" "3725.1" "3739.4" "2228.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "159.508" "24" "27" "42" "27" "1127" "128.1" "6.86" "153.35" "27" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "11" "0" "0.985" "0.982" "1.008" "0.996" "0.983" "1.037" "1.042" "0.864" "0.726" "3783.8" "3728.2" "3715.5" "3814.2" "3768.2" "3721.0" "3924.2" "3942.7" "3268.4" "2745.9" "" "" "" "" "" "" "" "" "" "" "3355.4" "3088.2" "3242.0" "2852.6" "3142.2" "3418.1" "3316.6" "3258.9" "2997.6" "2745.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "159.417" "61" "18" "62" "17" "325" "36.6" "6.79" "194.86" "18" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Glutathione conjugation; Formation of xylulose-5-phosphate" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "4" "2" "1.023" "0.988" "1.025" "0.972" "0.941" "0.970" "0.991" "0.942" "0.738" "6219.8" "6363.0" "6144.5" "6378.0" "6043.5" "5855.1" "6035.2" "6162.6" "5861.5" "4591.6" "" "" "" "" "" "" "" "" "" "" "5515.6" "5270.8" "5361.4" "4769.9" "5039.5" "5378.6" "5100.7" "5093.8" "5375.8" "4591.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "159.215" "47" "21" "44" "21" "491" "55.5" "6.74" "177.48" "21" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "" "5" "0" "1.132" "1.116" "1.121" "1.148" "1.089" "1.053" "1.095" "1.051" "0.646" "3257.3" "3687.0" "3635.0" "3650.0" "3738.4" "3546.2" "3430.2" "3567.6" "3424.6" "2104.8" "" "" "" "" "" "" "" "" "" "" "2888.5" "3054.1" "3171.7" "2729.7" "3117.3" "3257.6" "2899.1" "2948.9" "3140.8" "2104.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "158.964" "40" "26" "51" "25" "612" "68.2" "6.73" "184.47" "26" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Neutrophil degranulation; Pentose phosphate pathway" "Clear cell renal cell carcinoma pathways; Glucuronidation" "4" "1" "0.985" "1.037" "1.012" "1.018" "1.020" "1.037" "1.046" "1.026" "0.497" "7746.9" "7629.0" "8031.7" "7841.0" "7887.9" "7901.0" "8031.9" "8102.8" "7944.6" "3850.6" "" "" "" "" "" "" "" "" "" "" "6869.8" "6319.5" "7008.1" "5864.0" "6577.5" "7258.0" "6788.2" "6697.5" "7286.3" "3850.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "158.717" "56" "17" "87" "17" "261" "29.7" "7.05" "297.97" "17" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "" "17q12 copy number variation syndrome" "1" "0" "0.961" "0.981" "1.010" "0.982" "0.948" "0.959" "1.009" "0.995" "0.541" "10566.9" "10153.2" "10363.4" "10671.7" "10372.2" "10018.3" "10136.7" "10666.0" "10512.7" "5717.4" "" "" "" "" "" "" "" "" "" "" "9370.6" "8410.4" "9042.6" "7981.0" "8649.0" "9202.9" "8567.2" "8816.2" "9641.6" "5717.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "158.646" "44" "24" "35" "24" "661" "75.0" "6.37" "146.23" "24" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.011" "1.006" "1.033" "1.040" "1.025" "0.989" "1.014" "0.969" "0.830" "2949.8" "2983.6" "2968.5" "3045.9" "3068.0" "3022.3" "2918.7" "2990.8" "2858.0" "2449.2" "" "" "" "" "" "" "" "" "" "" "2615.8" "2471.5" "2590.2" "2277.9" "2558.3" "2776.3" "2466.8" "2472.1" "2621.2" "2449.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "158.611" "39" "12" "35" "12" "359" "39.2" "6.65" "157.15" "12" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "8" "0" "0.983" "1.059" "1.053" "1.042" "0.925" "1.069" "0.997" "1.043" "0.982" "4038.7" "3968.8" "4277.2" "4254.3" "4206.9" "3736.2" "4319.1" "4028.2" "4211.2" "3966.7" "" "" "" "" "" "" "" "" "" "" "3581.4" "3287.6" "3732.1" "3181.6" "3508.0" "3432.1" "3650.3" "3329.6" "3862.3" "3966.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "158.497" "53" "17" "36" "17" "401" "44.2" "5.21" "158.05" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Vasopressin-regulated water reabsorption" "12" "0" "0.995" "0.988" "0.924" "0.955" "1.009" "0.998" "0.868" "1.001" "2.558" "2426.1" "2414.1" "2395.8" "2241.6" "2316.1" "2449.0" "2420.8" "2106.6" "2427.6" "6205.1" "" "" "" "" "" "" "" "" "" "" "2151.4" "1999.7" "2090.5" "1676.4" "1931.3" "2249.7" "2046.0" "1741.3" "2226.5" "6205.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "158.110" "54" "21" "32" "21" "505" "58.2" "5.22" "129.73" "21" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "Reversal of alkylation damage by DNA dioxygenases" "FTO obesity variant mechanism" "2" "0" "1.019" "1.016" "1.051" "1.083" "1.067" "1.056" "1.080" "1.042" "0.629" "3849.6" "3921.1" "3911.6" "4044.9" "4171.0" "4107.1" "4066.1" "4157.8" "4011.8" "2420.1" "" "" "" "" "" "" "" "" "" "" "3413.7" "3248.0" "3413.1" "3025.0" "3478.0" "3772.8" "3436.5" "3436.7" "3679.4" "2420.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "157.901" "52" "14" "42" "14" "331" "36.5" "4.79" "176.17" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis induced DNA fragmentation" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "4" "0" "0.949" "0.979" "0.927" "0.963" "1.011" "1.006" "0.986" "0.970" "0.534" "4446.8" "4220.4" "4354.9" "4120.4" "4282.6" "4497.9" "4475.1" "4386.0" "4312.8" "2375.5" "" "" "" "" "" "" "" "" "" "" "3943.3" "3496.0" "3799.9" "3081.5" "3571.1" "4131.9" "3782.2" "3625.4" "3955.4" "2375.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.000" "False" "157.883" "34" "21" "37" "21" "737" "83.7" "6.18" "150.38" "21" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "12" "0" "1.012" "1.051" "1.049" "1.025" "1.055" "1.049" "1.040" "1.016" "0.665" "2594.6" "2625.9" "2726.4" "2722.0" "2660.7" "2737.3" "2721.6" "2698.0" "2636.5" "1724.3" "" "" "" "" "" "" "" "" "" "" "2300.8" "2175.2" "2378.9" "2035.7" "2218.6" "2514.5" "2300.1" "2230.1" "2418.0" "1724.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "157.825" "35" "16" "36" "16" "563" "61.3" "7.68" "152.92" "16" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency" "" "3" "0" "1.071" "1.044" "1.101" "1.120" "1.081" "1.055" "1.041" "1.007" "0.572" "2570.8" "2752.2" "2683.2" "2831.2" "2878.6" "2779.6" "2712.0" "2677.2" "2589.5" "1469.7" "" "" "" "" "" "" "" "" "" "" "2279.7" "2279.8" "2341.3" "2117.4" "2400.3" "2553.4" "2292.1" "2212.9" "2374.9" "1469.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "157.600" "57" "11" "49" "11" "206" "22.2" "5.36" "227.86" "11" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "0.972" "0.973" "0.896" "0.939" "0.925" "1.009" "0.971" "1.034" "0.541" "8224.3" "7995.2" "8003.5" "7368.0" "7720.3" "7608.3" "8300.1" "7985.6" "8503.8" "4448.6" "" "" "" "" "" "" "" "" "" "" "7293.2" "6622.9" "6983.5" "5510.3" "6437.7" "6989.0" "7014.9" "6600.7" "7799.1" "4448.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "157.587" "42" "15" "24" "15" "534" "60.2" "5.40" "124.55" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Neddylation" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "4" "0" "1.001" "1.028" "1.004" "1.006" "0.989" "1.243" "1.094" "1.148" "2.636" "1888.2" "1890.0" "1941.6" "1895.4" "1899.4" "1866.7" "2347.3" "2065.9" "2167.7" "4977.0" "" "" "" "" "" "" "" "" "" "" "1674.4" "1565.6" "1694.1" "1417.5" "1583.8" "1714.8" "1983.8" "1707.6" "1988.1" "4977.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "157.572" "53" "16" "50" "16" "359" "40.3" "6.74" "191.77" "16" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialic acid metabolism" "Sialylation" "2" "0" "0.995" "1.018" "1.020" "0.999" "1.025" "0.962" "1.007" "0.960" "0.666" "5089.7" "5063.8" "5183.1" "5191.9" "5082.7" "5219.4" "4897.1" "5124.2" "4885.2" "3388.7" "" "" "" "" "" "" "" "" "" "" "4513.4" "4194.6" "4522.5" "3882.8" "4238.3" "4794.6" "4138.8" "4235.5" "4480.4" "3388.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "157.229" "36" "24" "51" "24" "699" "73.6" "9.47" "168.73" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "0.921" "0.878" "0.866" "0.818" "0.816" "0.817" "0.776" "0.776" "0.339" "7191.1" "6621.7" "6312.4" "6225.5" "5885.5" "5868.4" "5875.2" "5581.7" "5578.9" "2437.4" "" "" "" "" "" "" "" "" "" "" "6376.9" "5485.1" "5507.8" "4655.8" "4907.7" "5390.8" "4965.5" "4613.7" "5116.6" "2437.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "157.183" "31" "26" "36" "26" "868" "96.0" "6.52" "140.83" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "5" "0" "1.054" "0.955" "1.115" "1.034" "0.972" "1.034" "0.279" "1.018" "17.520" "1682.5" "1772.8" "1606.6" "1875.3" "1738.9" "1635.4" "1740.1" "468.9" "1712.0" "29477.6" "" "" "" "" "" "" "" "" "" "" "1492.0" "1468.5" "1401.9" "1402.5" "1450.0" "1502.3" "1470.6" "387.6" "1570.2" "29477.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "157.090" "39" "26" "35" "25" "778" "88.0" "6.80" "134.75" "26" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "0.993" "0.936" "0.939" "0.902" "0.892" "0.951" "0.755" "0.927" "4.066" "2816.2" "2797.5" "2635.2" "2643.2" "2541.3" "2511.1" "2677.7" "2127.5" "2609.2" "11451.3" "" "" "" "" "" "" "" "" "" "" "2497.4" "2317.3" "2299.3" "1976.7" "2119.1" "2306.7" "2263.1" "1758.6" "2393.0" "11451.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "156.856" "66" "7" "33" "7" "189" "20.7" "5.57" "160.16" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "0.992" "1.007" "1.035" "1.067" "1.034" "0.981" "1.007" "1.007" "0.662" "2147.5" "2129.6" "2162.1" "2222.4" "2292.3" "2220.6" "2105.7" "2162.4" "2162.8" "1422.0" "" "" "" "" "" "" "" "" "" "" "1904.4" "1764.1" "1886.5" "1662.0" "1911.5" "2039.8" "1779.7" "1787.3" "1983.6" "1422.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "156.344" "23" "21" "34" "21" "979" "107.1" "5.74" "145.16" "21" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "Ciliopathies" "4" "0" "1.046" "1.018" "1.019" "1.051" "1.033" "1.190" "1.148" "1.142" "1.525" "2693.5" "2818.2" "2741.6" "2744.7" "2829.8" "2782.0" "3206.6" "3091.3" "3075.4" "4108.7" "" "" "" "" "" "" "" "" "" "" "2388.6" "2334.4" "2392.2" "2052.7" "2359.7" "2555.5" "2710.1" "2555.2" "2820.5" "4108.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "156.179" "43" "18" "66" "17" "437" "50.6" "8.63" "233.22" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "MAPK6/MAPK4 signaling" "" "1" "1" "0.975" "0.957" "0.963" "0.911" "0.937" "0.917" "0.966" "0.943" "0.638" "6555.9" "6393.1" "6276.5" "6314.3" "5971.7" "6141.1" "6010.2" "6331.6" "6179.8" "4184.5" "" "" "" "" "" "" "" "" "" "" "5813.6" "5295.8" "5476.6" "4722.2" "4979.6" "5641.3" "5079.6" "5233.5" "5667.8" "4184.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396121455567897427" "False" "High" "IsMasterProtein" "Q9Y4K1" "Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=4" "0.000" "False" "156.172" "14" "24" "38" "24" "2131" "231.6" "5.81" "141.24" "24" "" "" "other molecular function" "Pf00030, Pf00652" "" "ENSG00000112297" "CRYBG1" "A0A0J9YWL0" "" "" "0" "0" "1.017" "0.950" "0.986" "0.985" "0.971" "0.885" "0.871" "0.946" "2.123" "2926.5" "2977.7" "2780.9" "2885.0" "2883.1" "2841.5" "2590.8" "2549.4" "2769.1" "6214.3" "" "" "" "" "" "" "" "" "" "" "2595.2" "2466.6" "2426.4" "2157.6" "2404.1" "2610.2" "2189.7" "2107.3" "2539.6" "6214.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "155.961" "24" "19" "83" "19" "709" "78.3" "5.25" "295.36" "19" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "0.990" "1.001" "0.927" "0.965" "0.968" "0.892" "0.948" "0.968" "0.526" "12592.9" "12466.9" "12609.5" "11670.0" "12149.0" "12187.2" "11233.9" "11933.5" "12190.0" "6624.2" "" "" "" "" "" "" "" "" "" "" "11167.1" "10327.0" "11002.4" "8727.6" "10130.6" "11195.3" "9494.5" "9863.9" "11179.9" "6624.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "155.859" "70" "21" "56" "16" "271" "31.5" "6.87" "189.38" "21" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "PI and PC transport between ER and Golgi membranes" "" "1" "4" "0.981" "1.001" "0.942" "0.938" "0.929" "0.986" "1.033" "0.975" "0.632" "7098.1" "6965.4" "7105.7" "6689.2" "6655.7" "6596.3" "7000.9" "7333.8" "6923.3" "4485.6" "" "" "" "" "" "" "" "" "" "" "6294.5" "5769.8" "6200.0" "5002.6" "5550.0" "6059.4" "5916.9" "6061.9" "6349.6" "4485.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "155.067" "33" "17" "28" "17" "695" "76.1" "8.70" "130.40" "17" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "0.985" "0.931" "0.941" "0.926" "0.911" "0.862" "0.922" "0.948" "0.506" "3543.8" "3491.9" "3299.0" "3336.0" "3281.0" "3227.4" "3054.2" "3265.7" "3359.4" "1794.2" "" "" "" "" "" "" "" "" "" "" "3142.5" "2892.5" "2878.5" "2494.9" "2735.9" "2964.7" "2581.3" "2699.4" "3081.0" "1794.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "155.045" "67" "12" "38" "12" "234" "25.9" "7.43" "187.85" "12" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Antigen processing: Ubiquitination & Proteasome degradation; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Neutrophil degranulation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "1.108" "1.097" "0.969" "1.019" "1.032" "1.030" "0.999" "1.052" "0.522" "3144.6" "3484.7" "3450.9" "3045.8" "3204.2" "3243.8" "3237.5" "3141.3" "3306.9" "1642.5" "" "" "" "" "" "" "" "" "" "" "2788.5" "2886.5" "3011.1" "2277.9" "2671.9" "2979.8" "2736.2" "2596.5" "3032.9" "1642.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "155.001" "31" "22" "31" "20" "800" "90.2" "6.13" "126.96" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "mRNA Splicing - Major Pathway" "" "1" "1" "1.048" "1.020" "1.012" "1.031" "0.996" "0.920" "0.933" "0.923" "0.537" "2757.4" "2889.7" "2812.8" "2789.7" "2842.1" "2745.9" "2537.9" "2572.4" "2544.5" "1480.7" "" "" "" "" "" "" "" "" "" "" "2445.2" "2393.7" "2454.3" "2086.3" "2369.9" "2522.4" "2145.0" "2126.2" "2333.6" "1480.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "154.884" "47" "26" "47" "26" "528" "59.1" "7.05" "171.97" "26" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Cytosolic tRNA aminoacylation" "Nephrotic syndrome" "2" "0" "0.993" "1.006" "1.016" "0.982" "0.965" "1.082" "0.869" "1.077" "4.865" "4345.7" "4313.5" "4371.7" "4414.6" "4269.1" "4194.7" "4701.7" "3775.2" "4681.1" "21141.9" "" "" "" "" "" "" "" "" "" "" "3853.7" "3573.0" "3814.5" "3301.6" "3559.8" "3853.3" "3973.7" "3120.5" "4293.2" "21141.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "154.872" "47" "19" "32" "19" "494" "56.0" "5.30" "126.37" "19" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "" "2" "0" "1.042" "1.043" "0.967" "0.944" "0.941" "1.034" "0.918" "0.996" "2.352" "3219.4" "3355.0" "3359.2" "3113.6" "3039.5" "3030.9" "3328.9" "2957.0" "3205.3" "7572.7" "" "" "" "" "" "" "" "" "" "" "2854.9" "2779.1" "2931.0" "2328.6" "2534.5" "2784.3" "2813.4" "2444.1" "2939.7" "7572.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3818146926309850822" "False" "High" "IsMasterProtein" "O95671" "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3" "0.000" "False" "154.706" "38" "23" "42" "23" "621" "68.8" "6.07" "157.74" "23" "other metabolic processes" "cytosol" "other molecular function" "Pf00891, Pf02545, Pf16864" "8623" "ENSG00000169093; ENSG00000292339" "ASMTL" "B4DX75; F5GXH4; hsa:8623; J3JS33; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6" "" "" "0" "0" "0.956" "0.943" "0.845" "0.795" "0.697" "0.639" "0.626" "0.640" "1.083" "4692.0" "4483.5" "4422.4" "3963.4" "3730.9" "3269.6" "2997.0" "2936.1" "3005.2" "5081.7" "" "" "" "" "" "" "" "" "" "" "4160.8" "3713.9" "3858.7" "2964.1" "3111.1" "3003.5" "2532.9" "2426.9" "2756.2" "5081.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "154.673" "43" "23" "64" "22" "530" "60.1" "9.13" "216.16" "23" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "Vpr-mediated nuclear import of PICs; Formation of WDR5-containing histone-modifying complexes; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "MECP2 and associated Rett syndrome" "8" "1" "0.955" "0.949" "0.885" "0.859" "0.884" "0.831" "0.853" "0.866" "0.843" "9258.6" "8846.4" "8784.2" "8198.2" "7957.0" "8180.6" "7695.1" "7899.6" "8019.0" "7806.6" "" "" "" "" "" "" "" "" "" "" "8210.3" "7327.9" "7664.7" "6131.2" "6635.0" "7514.7" "6503.6" "6529.6" "7354.5" "7806.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "154.073" "36" "20" "35" "20" "654" "73.2" "6.33" "125.89" "20" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "mRNA Splicing - Major Pathway" "" "1" "0" "1.004" "0.989" "0.981" "0.999" "1.011" "0.920" "0.984" "0.980" "0.612" "3302.4" "3315.7" "3266.3" "3241.0" "3299.7" "3339.8" "3037.9" "3248.6" "3236.0" "2022.0" "" "" "" "" "" "" "" "" "" "" "2928.5" "2746.6" "2850.0" "2423.8" "2751.5" "3068.0" "2567.5" "2685.2" "2967.8" "2022.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "153.888" "51" "14" "48" "14" "241" "26.5" "8.13" "187.45" "14" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "1.071" "1.101" "1.037" "1.081" "1.056" "1.080" "1.043" "1.070" "0.659" "4946.9" "5296.2" "5444.2" "5128.1" "5346.5" "5225.0" "5343.6" "5157.6" "5292.4" "3262.4" "" "" "" "" "" "" "" "" "" "" "4386.8" "4387.1" "4750.3" "3835.2" "4458.2" "4799.7" "4516.2" "4263.1" "4853.9" "3262.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "153.791" "46" "24" "52" "24" "528" "60.5" "7.52" "195.57" "24" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "0.950" "0.986" "0.969" "0.945" "1.015" "0.951" "0.975" "0.971" "0.578" "5874.1" "5578.5" "5792.7" "5694.5" "5552.1" "5962.9" "5588.2" "5727.3" "5705.8" "3392.4" "" "" "" "" "" "" "" "" "" "" "5209.0" "4621.0" "5054.4" "4258.7" "4629.7" "5477.6" "4722.9" "4734.0" "5233.0" "3392.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "153.395" "49" "12" "44" "12" "334" "37.6" "6.54" "186.91" "12" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "TGF-beta signaling pathway" "5" "0" "1.037" "1.081" "1.032" "1.110" "1.098" "1.062" "1.084" "1.039" "0.678" "4494.5" "4661.9" "4856.9" "4640.4" "4990.6" "4936.7" "4774.2" "4873.1" "4668.9" "3045.7" "" "" "" "" "" "" "" "" "" "" "3985.6" "3861.7" "4237.9" "3470.4" "4161.5" "4534.9" "4035.0" "4028.0" "4282.0" "3045.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "153.259" "64" "16" "89" "10" "209" "24.0" "7.81" "291.89" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Apoptosis induced DNA fragmentation" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "4" "3" "0.952" "0.908" "0.860" "0.902" "0.781" "0.690" "0.838" "0.851" "0.463" "12004.3" "11423.3" "10901.1" "10323.3" "10824.5" "9381.0" "8281.4" "10056.4" "10211.7" "5561.8" "" "" "" "" "" "" "" "" "" "" "10645.1" "9462.5" "9511.8" "7720.5" "9026.2" "8617.5" "6999.1" "8312.3" "9365.5" "5561.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "153.027" "52" "13" "53" "13" "315" "37.1" "4.64" "212.18" "13" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "5" "0" "0.966" "0.968" "0.962" "0.968" "1.007" "0.945" "1.013" "0.971" "0.523" "7895.6" "7625.2" "7640.7" "7591.8" "7645.4" "7951.0" "7460.7" "7995.8" "7663.6" "4127.2" "" "" "" "" "" "" "" "" "" "" "7001.7" "6316.4" "6666.9" "5677.7" "6375.2" "7303.9" "6305.5" "6609.1" "7028.5" "4127.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "152.751" "35" "27" "39" "27" "870" "98.0" "7.44" "145.37" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Recycling pathway of L1; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "14" "0" "0.955" "0.947" "1.009" "0.934" "0.911" "1.120" "1.029" "1.019" "2.251" "2231.2" "2131.8" "2113.1" "2251.6" "2083.7" "2033.4" "2499.6" "2295.3" "2273.0" "5022.8" "" "" "" "" "" "" "" "" "" "" "1978.6" "1765.9" "1843.8" "1683.9" "1737.5" "1867.9" "2112.6" "1897.2" "2084.7" "5022.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "152.623" "25" "21" "59" "21" "825" "90.5" "6.00" "206.47" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "4" "0" "0.969" "0.946" "0.981" "0.924" "0.967" "0.956" "0.519" "0.993" "9.536" "3461.5" "3355.5" "3275.9" "3394.5" "3200.0" "3346.6" "3310.3" "1796.3" "3436.6" "33008.1" "" "" "" "" "" "" "" "" "" "" "3069.6" "2779.5" "2858.4" "2538.6" "2668.4" "3074.3" "2797.7" "1484.8" "3151.8" "33008.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "152.161" "56" "14" "79" "14" "216" "24.4" "7.49" "306.65" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "11" "0" "1.024" "1.100" "1.051" "1.075" "1.121" "1.040" "1.090" "1.094" "0.543" "10320.2" "10570.8" "11350.4" "10847.2" "11095.7" "11571.2" "10731.2" "11245.5" "11286.2" "5604.7" "" "" "" "" "" "" "" "" "" "" "9151.8" "8756.3" "9903.7" "8112.2" "9252.3" "10629.4" "9069.6" "9295.2" "10351.0" "5604.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "151.994" "57" "26" "43" "26" "501" "57.1" "6.55" "154.94" "26" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Alanine and aspartate metabolism" "3" "0" "1.038" "1.002" "1.088" "1.093" "1.068" "1.179" "1.016" "1.104" "3.730" "3826.5" "3972.3" "3832.2" "4163.7" "4183.1" "4085.6" "4512.1" "3887.8" "4225.4" "14274.1" "" "" "" "" "" "" "" "" "" "" "3393.2" "3290.5" "3343.8" "3113.9" "3488.2" "3753.1" "3813.4" "3213.6" "3875.2" "14274.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "151.949" "59" "17" "51" "17" "254" "29.5" "5.95" "221.52" "17" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "1.031" "1.091" "1.049" "1.062" "1.021" "1.089" "1.107" "1.063" "0.521" "5625.4" "5800.9" "6140.0" "5898.9" "5972.4" "5741.2" "6128.1" "6229.5" "5980.7" "2932.0" "" "" "" "" "" "" "" "" "" "" "4988.5" "4805.2" "5357.4" "4411.6" "4980.1" "5274.0" "5179.2" "5149.1" "5485.1" "2932.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "151.652" "63" "11" "75" "11" "187" "21.0" "7.53" "336.36" "11" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "9" "0" "0.954" "1.007" "0.954" "0.969" "1.068" "0.966" "1.064" "1.037" "0.504" "8703.1" "8301.6" "8768.2" "8307.0" "8430.2" "9297.9" "8408.4" "9258.7" "9024.2" "4387.7" "" "" "" "" "" "" "" "" "" "" "7717.8" "6876.6" "7650.6" "6212.5" "7029.7" "8541.2" "7106.5" "7653.0" "8276.4" "4387.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "151.648" "28" "19" "31" "19" "881" "96.7" "4.55" "135.94" "19" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "COPII-mediated vesicle transport" "" "1" "0" "0.985" "0.991" "1.025" "0.996" "0.939" "0.941" "0.943" "0.886" "1.014" "3520.0" "3468.8" "3489.2" "3608.1" "3504.8" "3306.1" "3312.7" "3317.7" "3118.9" "3569.0" "" "" "" "" "" "" "" "" "" "" "3121.5" "2873.4" "3044.5" "2698.4" "2922.6" "3037.1" "2799.8" "2742.3" "2860.5" "3569.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "151.199" "56" "11" "38" "8" "225" "24.7" "4.67" "169.20" "11" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Eukaryotic Translation Elongation" "Translation factors" "2" "0" "0.914" "0.955" "0.805" "0.847" "0.862" "0.836" "0.741" "0.898" "3.513" "4340.5" "3968.6" "4145.4" "3494.3" "3675.4" "3741.8" "3627.2" "3218.2" "3895.9" "15247.7" "" "" "" "" "" "" "" "" "" "" "3849.1" "3287.4" "3617.0" "2613.3" "3064.8" "3437.3" "3065.6" "2660.1" "3573.1" "15247.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "151.082" "43" "14" "34" "14" "386" "42.3" "5.97" "136.00" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "Cyclin A/B1/B2 associated events during G2/M transition" "" "1" "0" "0.999" "1.016" "0.977" "0.984" "1.029" "1.018" "1.026" "0.991" "0.597" "5699.6" "5692.1" "5791.6" "5567.5" "5607.6" "5864.4" "5804.9" "5845.5" "5647.0" "3405.0" "" "" "" "" "" "" "" "" "" "" "5054.3" "4715.1" "5053.4" "4163.8" "4676.0" "5387.1" "4906.0" "4831.7" "5179.0" "3405.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "150.893" "77" "17" "63" "17" "235" "26.4" "5.64" "219.45" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "0.956" "1.028" "0.924" "0.975" "1.009" "0.958" "1.024" "1.051" "0.521" "8418.8" "8049.7" "8655.7" "7777.3" "8212.0" "8498.7" "8069.1" "8622.2" "8849.3" "4385.1" "" "" "" "" "" "" "" "" "" "" "7465.6" "6668.0" "7552.5" "5816.4" "6847.7" "7807.0" "6819.7" "7126.9" "8116.0" "4385.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "150.826" "43" "11" "35" "10" "392" "42.9" "5.97" "128.70" "11" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "0" "1.062" "1.065" "1.088" "1.085" "1.096" "1.087" "1.091" "1.055" "0.574" "2406.1" "2554.2" "2562.7" "2619.0" "2609.7" "2637.5" "2616.3" "2624.9" "2537.5" "1380.6" "" "" "" "" "" "" "" "" "" "" "2133.7" "2115.8" "2236.1" "1958.7" "2176.1" "2422.8" "2211.2" "2169.7" "2327.3" "1380.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.000" "False" "150.051" "27" "25" "40" "25" "998" "112.3" "6.39" "149.87" "25" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "3" "0" "1.055" "0.916" "1.029" "0.934" "0.957" "0.935" "0.254" "0.892" "14.778" "1969.5" "2077.8" "1804.2" "2027.3" "1840.2" "1885.7" "1841.8" "499.5" "1756.7" "29104.1" "" "" "" "" "" "" "" "" "" "" "1746.5" "1721.2" "1574.2" "1516.1" "1534.5" "1732.2" "1556.6" "412.9" "1611.1" "29104.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "149.439" "31" "21" "40" "21" "729" "79.5" "5.22" "161.83" "21" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "1.019" "1.027" "1.061" "1.055" "0.996" "0.970" "1.048" "1.043" "0.650" "3994.8" "4071.5" "4102.8" "4238.3" "4213.7" "3978.1" "3874.1" "4184.7" "4166.5" "2594.7" "" "" "" "" "" "" "" "" "" "" "3542.5" "3372.7" "3579.9" "3169.7" "3513.7" "3654.3" "3274.2" "3459.0" "3821.3" "2594.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "149.223" "38" "23" "38" "23" "719" "79.7" "5.45" "138.62" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "5q35 copy number variation" "6" "0" "1.001" "0.976" "0.951" "0.971" "0.984" "0.945" "0.927" "0.931" "0.768" "3883.8" "3888.2" "3790.7" "3692.8" "3771.7" "3821.6" "3672.1" "3599.0" "3617.2" "2981.0" "" "" "" "" "" "" "" "" "" "" "3444.1" "3220.8" "3307.6" "2761.7" "3145.1" "3510.6" "3103.5" "2974.8" "3317.5" "2981.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "148.929" "34" "21" "52" "21" "639" "71.4" "6.40" "177.93" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Nephrin family interactions" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "5" "0" "1.000" "1.036" "0.973" "1.012" "0.998" "0.959" "0.976" "0.996" "0.654" "6024.0" "6026.5" "6238.9" "5859.8" "6096.1" "6009.0" "5778.9" "5880.0" "6001.6" "3940.2" "" "" "" "" "" "" "" "" "" "" "5342.0" "4992.1" "5443.7" "4382.3" "5083.3" "5519.9" "4884.1" "4860.2" "5504.3" "3940.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "148.598" "22" "18" "163" "2" "639" "70.0" "5.74" "571.48" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Regulation of HSF1-mediated heat shock response; Meiotic synapsis; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Attenuation phase" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "10" "0" "0.878" "1.178" "0.833" "0.793" "0.875" "0.913" "0.900" "0.745" "0.632" "1411.4" "1239.6" "1662.0" "1176.0" "1119.4" "1235.1" "1288.3" "1270.8" "1051.9" "892.6" "" "" "" "" "" "" "" "" "" "" "1251.6" "1026.8" "1450.2" "879.5" "933.4" "1134.6" "1088.8" "1050.4" "964.7" "892.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "148.530" "46" "19" "33" "19" "468" "50.1" "7.06" "126.12" "19" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "0.998" "0.981" "0.961" "0.936" "0.930" "0.927" "1.030" "0.992" "0.428" "4351.9" "4344.6" "4269.7" "4182.7" "4074.2" "4048.5" "4036.2" "4482.9" "4318.2" "1862.0" "" "" "" "" "" "" "" "" "" "" "3859.1" "3598.8" "3725.5" "3128.1" "3397.3" "3719.0" "3411.2" "3705.5" "3960.3" "1862.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "148.287" "40" "21" "50" "13" "633" "70.9" "8.13" "190.82" "21" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "1.165" "1.033" "1.054" "1.049" "1.044" "0.977" "0.542" "0.949" "9.689" "661.7" "770.6" "683.4" "697.5" "693.8" "690.5" "646.5" "358.7" "628.1" "6411.1" "" "" "" "" "" "" "" "" "" "" "586.7" "638.3" "596.3" "521.6" "578.5" "634.3" "546.4" "296.5" "576.0" "6411.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "148.249" "21" "23" "28" "23" "1262" "144.4" "6.15" "107.58" "23" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Amino acid metabolism" "3" "0" "1.386" "1.011" "1.073" "1.082" "1.097" "1.144" "0.719" "1.144" "7.669" "767.5" "1063.9" "775.7" "823.4" "830.2" "842.3" "877.7" "552.1" "878.1" "5885.8" "" "" "" "" "" "" "" "" "" "" "680.6" "881.3" "676.8" "615.8" "692.3" "773.8" "741.8" "456.3" "805.3" "5885.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "148.176" "29" "27" "36" "27" "1052" "117.9" "6.14" "136.15" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "1.000" "1.008" "0.922" "0.947" "0.908" "0.940" "0.829" "0.981" "3.605" "2808.9" "2809.6" "2832.0" "2588.6" "2660.7" "2551.0" "2641.0" "2328.2" "2756.8" "10127.2" "" "" "" "" "" "" "" "" "" "" "2490.9" "2327.4" "2471.0" "1935.9" "2218.7" "2343.4" "2232.1" "1924.4" "2528.4" "10127.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "148.053" "64" "12" "38" "12" "244" "25.9" "8.10" "156.56" "12" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "Formation of xylulose-5-phosphate; Essential pentosuria" "" "2" "0" "0.996" "1.064" "1.105" "1.124" "1.019" "1.115" "1.150" "1.009" "0.478" "3244.7" "3231.8" "3452.6" "3586.5" "3646.8" "3305.8" "3617.8" "3732.1" "3274.8" "1550.2" "" "" "" "" "" "" "" "" "" "" "2877.3" "2677.0" "3012.5" "2682.3" "3041.0" "3036.7" "3057.6" "3084.9" "3003.4" "1550.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "147.854" "39" "11" "25" "10" "340" "36.5" "5.41" "123.80" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "1.011" "1.000" "1.015" "1.012" "1.045" "0.942" "0.987" "0.993" "0.502" "3317.6" "3355.6" "3318.9" "3368.6" "3355.9" "3466.7" "3123.8" "3273.4" "3295.9" "1664.3" "" "" "" "" "" "" "" "" "" "" "2942.0" "2779.6" "2895.9" "2519.3" "2798.3" "3184.6" "2640.1" "2705.7" "3022.8" "1664.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "147.781" "68" "11" "55" "5" "180" "20.5" "6.79" "213.28" "11" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2q37 copy number variation syndrome" "3" "0" "1.000" "1.005" "1.049" "1.020" "0.999" "1.065" "0.996" "0.935" "0.539" "3545.7" "3546.0" "3563.7" "3718.0" "3615.6" "3543.5" "3775.2" "3531.9" "3314.4" "1911.8" "" "" "" "" "" "" "" "" "" "" "3144.2" "2937.3" "3109.5" "2780.6" "3014.9" "3255.1" "3190.7" "2919.4" "3039.8" "1911.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "147.662" "45" "13" "51" "13" "317" "34.3" "5.97" "213.17" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "1.082" "1.122" "1.124" "1.206" "1.261" "1.266" "1.247" "1.161" "0.475" "5822.3" "6302.0" "6531.1" "6544.4" "7019.7" "7341.5" "7371.6" "7262.2" "6758.4" "2763.2" "" "" "" "" "" "" "" "" "" "" "5163.1" "5220.3" "5698.7" "4894.3" "5853.5" "6744.0" "6230.1" "6002.7" "6198.4" "2763.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "147.659" "56" "14" "33" "14" "260" "29.9" "5.73" "143.49" "14" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "1.010" "0.991" "0.993" "0.970" "0.962" "1.106" "1.147" "1.124" "0.549" "3907.4" "3946.1" "3873.4" "3881.0" "3788.3" "3757.4" "4319.7" "4483.2" "4392.8" "2143.9" "" "" "" "" "" "" "" "" "" "" "3465.0" "3268.8" "3379.7" "2902.5" "3159.0" "3451.6" "3650.9" "3705.7" "4028.8" "2143.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "147.614" "14" "26" "34" "24" "2229" "242.8" "8.34" "125.28" "26" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "0.963" "0.981" "0.991" "0.941" "0.951" "0.935" "0.959" "0.941" "0.441" "3974.8" "3828.5" "3900.0" "3937.8" "3741.5" "3779.6" "3717.2" "3810.1" "3740.8" "1753.8" "" "" "" "" "" "" "" "" "" "" "3524.8" "3171.3" "3403.0" "2945.0" "3119.9" "3472.0" "3141.6" "3149.3" "3430.8" "1753.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "147.466" "59" "12" "124" "12" "189" "19.9" "6.79" "423.75" "12" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "8" "0" "0.964" "0.995" "0.946" "0.963" "0.983" "0.912" "0.971" "1.045" "0.560" "12834.8" "12375.9" "12776.5" "12141.6" "12354.3" "12610.4" "11702.0" "12462.0" "13418.0" "7186.3" "" "" "" "" "" "" "" "" "" "" "11381.7" "10251.5" "11148.1" "9080.3" "10301.8" "11584.1" "9890.0" "10300.7" "12306.2" "7186.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "147.331" "39" "22" "38" "21" "623" "69.9" "5.67" "128.32" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "1" "0.986" "1.038" "1.016" "1.007" "0.958" "1.036" "0.982" "1.006" "2.118" "2563.1" "2526.3" "2660.7" "2605.0" "2581.2" "2456.3" "2656.5" "2518.1" "2578.9" "5428.1" "" "" "" "" "" "" "" "" "" "" "2272.9" "2092.7" "2321.6" "1948.2" "2152.3" "2256.4" "2245.1" "2081.4" "2365.2" "5428.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "147.300" "29" "14" "60" "14" "504" "55.1" "6.61" "225.22" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex" "" "5" "0" "0.999" "1.011" "1.009" "0.987" "0.985" "1.012" "1.004" "0.967" "0.458" "6230.0" "6222.5" "6299.0" "6286.3" "6151.6" "6133.9" "6302.1" "6256.9" "6023.9" "2852.3" "" "" "" "" "" "" "" "" "" "" "5524.6" "5154.4" "5496.2" "4701.3" "5129.6" "5634.7" "5326.3" "5171.8" "5524.7" "2852.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "147.248" "65" "18" "33" "18" "318" "35.2" "8.94" "130.95" "18" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Neutrophil degranulation; Pentose phosphate pathway" "Pentose phosphate pathway in senescent cells" "3" "0" "1.048" "1.054" "1.095" "1.054" "1.064" "1.071" "1.105" "0.995" "0.526" "2829.3" "2965.9" "2982.1" "3097.6" "2981.9" "3011.0" "3030.0" "3126.9" "2815.1" "1487.9" "" "" "" "" "" "" "" "" "" "" "2509.0" "2456.8" "2602.0" "2316.6" "2486.5" "2765.9" "2560.8" "2584.6" "2581.8" "1487.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "147.082" "42" "24" "45" "24" "497" "55.8" "7.55" "154.81" "24" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.016" "1.004" "1.026" "1.010" "1.029" "1.014" "1.006" "0.925" "0.609" "5706.4" "5797.7" "5731.3" "5855.1" "5761.3" "5872.6" "5788.6" "5741.3" "5277.3" "3476.9" "" "" "" "" "" "" "" "" "" "" "5060.4" "4802.5" "5000.9" "4378.8" "4804.1" "5394.6" "4892.3" "4745.6" "4840.0" "3476.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "146.939" "48" "27" "55" "27" "589" "66.1" "6.84" "181.19" "27" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "Cytosolic tRNA aminoacylation" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "3" "0" "1.013" "1.016" "1.032" "1.033" "0.989" "1.292" "1.210" "1.370" "3.126" "3676.1" "3725.5" "3733.6" "3792.2" "3798.5" "3637.1" "4750.0" "4446.4" "5036.4" "11490.8" "" "" "" "" "" "" "" "" "" "" "3259.9" "3086.0" "3257.8" "2836.1" "3167.4" "3341.1" "4014.5" "3675.3" "4619.1" "11490.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-92542688516821267" "False" "High" "IsMasterProtein" "Q14699" "Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4" "0.000" "False" "146.655" "41" "19" "45" "19" "578" "63.1" "5.67" "189.75" "19" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf15250" "23180" "ENSG00000131378" "RFTN1" "hsa:23180; Q0D2G0; Q14699; Q496Y2; Q4QQI7; Q5JB48; Q7Z7P2" "" "" "0" "0" "0.949" "0.862" "0.841" "0.813" "0.758" "0.674" "0.758" "0.801" "0.498" "5087.3" "4828.4" "4384.0" "4279.6" "4137.4" "3855.5" "3428.3" "3853.7" "4076.0" "2531.3" "" "" "" "" "" "" "" "" "" "" "4511.3" "3999.6" "3825.3" "3200.6" "3450.0" "3541.7" "2897.5" "3185.4" "3738.3" "2531.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442629486260098393" "False" "High" "IsMasterProtein" "Q05397" "Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2" "0.000" "False" "146.248" "27" "27" "41" "26" "1052" "119.2" "6.62" "144.33" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "5747" "ENSG00000169398" "PTK2" "B4E2N6; F5H4S4; hsa:5747; J3QT16; Q05397; Q14291; Q8IYN9; Q9UD85" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAF/MAP kinase cascade; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Signal regulatory protein family interactions; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; MET activates PTK2 signaling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Apoptotic cleavage of cellular proteins" "Androgen receptor signaling pathway; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Hippo-Merlin signaling dysregulation; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Small cell lung cancer; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q13 copy number variation syndrome; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; ErbB signaling pathway" "51" "1" "1.012" "1.027" "1.117" "1.054" "1.058" "1.027" "1.018" "1.005" "0.652" "2931.6" "2967.9" "3012.0" "3275.3" "3089.1" "3101.2" "3011.0" "2984.3" "2944.8" "1910.5" "" "" "" "" "" "" "" "" "" "" "2599.7" "2458.4" "2628.1" "2449.5" "2575.9" "2848.8" "2544.8" "2466.8" "2700.8" "1910.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "146.193" "65" "15" "73" "15" "224" "25.0" "6.38" "269.51" "15" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "5" "0" "1.032" "1.030" "1.063" "1.036" "1.057" "1.062" "1.072" "0.968" "0.502" "8252.8" "8513.2" "8497.1" "8773.9" "8553.7" "8725.8" "8760.5" "8848.4" "7992.7" "4142.5" "" "" "" "" "" "" "" "" "" "" "7318.5" "7051.9" "7414.1" "6561.8" "7132.6" "8015.6" "7404.0" "7313.8" "7330.4" "4142.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "146.189" "45" "10" "34" "9" "277" "31.6" "6.54" "156.60" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "Degradation of the extracellular matrix; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; Caspase-mediated cleavage of cytoskeletal proteins; NADE modulates death signalling; Other interleukin signaling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "60" "0" "1.035" "1.010" "1.040" "1.042" "1.033" "1.098" "1.111" "1.051" "0.580" "2478.5" "2565.7" "2504.5" "2577.9" "2581.6" "2560.8" "2720.4" "2754.7" "2605.8" "1436.5" "" "" "" "" "" "" "" "" "" "" "2197.9" "2125.3" "2185.3" "1928.0" "2152.7" "2352.4" "2299.2" "2277.0" "2389.8" "1436.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "146.142" "70" "14" "85" "14" "199" "22.4" "8.25" "289.46" "14" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "Platelet degranulation" "" "1" "0" "0.978" "1.013" "0.947" "0.941" "0.929" "0.958" "0.964" "1.024" "1.009" "8514.3" "8327.7" "8623.6" "8059.8" "8009.2" "7907.8" "8154.5" "8211.4" "8721.9" "8590.7" "" "" "" "" "" "" "" "" "" "" "7550.3" "6898.3" "7524.5" "6027.7" "6678.6" "7264.2" "6891.9" "6787.3" "7999.1" "8590.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "145.859" "47" "16" "49" "16" "413" "46.2" "7.01" "197.53" "16" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "11" "0" "1.011" "1.018" "1.025" "1.025" "1.030" "1.044" "1.046" "0.997" "0.481" "6884.2" "6962.5" "7006.2" "7058.7" "7058.0" "7091.1" "7183.8" "7200.2" "6864.8" "3314.5" "" "" "" "" "" "" "" "" "" "" "6104.8" "5767.4" "6113.3" "5278.9" "5885.4" "6514.0" "6071.5" "5951.4" "6295.9" "3314.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "145.836" "45" "13" "54" "13" "328" "35.8" "8.00" "202.61" "13" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Mitochondrial protein degradation; Peroxisomal protein import" "Fatty acid biosynthesis; IL-18 signaling pathway" "4" "0" "0.969" "0.948" "0.950" "0.925" "0.859" "1.003" "1.025" "0.990" "0.433" "8492.9" "8230.7" "8048.6" "8067.8" "7854.6" "7295.9" "8519.7" "8702.8" "8407.3" "3675.4" "" "" "" "" "" "" "" "" "" "" "7531.3" "6817.9" "7022.8" "6033.6" "6549.7" "6702.1" "7200.5" "7193.5" "7710.7" "3675.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "145.615" "69" "13" "40" "13" "207" "23.5" "6.70" "163.76" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "RHOG GTPase cycle; TBC/RABGAPs; Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Prevention of phagosomal-lysosomal fusion; Suppression of autophagy; RHOH GTPase cycle" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "20" "0" "0.962" "1.039" "0.967" "1.005" "1.025" "0.929" "0.932" "0.958" "0.505" "4580.1" "4405.4" "4757.6" "4427.0" "4604.2" "4694.6" "4256.6" "4269.0" "4388.8" "2315.2" "" "" "" "" "" "" "" "" "" "" "4061.6" "3649.2" "4151.2" "3310.8" "3839.2" "4312.6" "3597.5" "3528.6" "4025.2" "2315.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "145.055" "58" "12" "58" "12" "248" "27.9" "8.46" "222.34" "12" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.006" "1.053" "1.010" "1.044" "0.998" "0.984" "1.001" "0.967" "0.547" "6766.9" "6806.2" "7125.3" "6834.4" "7061.6" "6750.1" "6659.4" "6771.3" "6544.3" "3702.4" "" "" "" "" "" "" "" "" "" "" "6000.8" "5637.9" "6217.2" "5111.2" "5888.5" "6200.8" "5628.2" "5597.0" "6002.1" "3702.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "144.886" "66" "13" "188" "12" "165" "18.0" "7.81" "545.64" "13" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "Prolactin signaling pathway" "16" "0" "1.037" "1.028" "1.008" "0.975" "0.988" "0.990" "0.983" "1.055" "1.020" "16609.0" "17226.2" "17077.8" "16736.3" "16194.1" "16403.9" "16444.0" "16320.3" "17514.6" "16947.0" "" "" "" "" "" "" "" "" "" "" "14728.6" "14269.4" "14901.2" "12516.6" "13503.7" "15068.8" "13897.8" "13489.9" "16063.3" "16947.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "144.296" "45" "11" "54" "11" "260" "30.5" "5.21" "248.81" "11" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Pyrimidine salvage; Purine salvage" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "1.051" "1.088" "1.072" "1.121" "1.046" "1.077" "1.088" "1.029" "0.447" "7990.2" "8397.6" "8696.2" "8564.8" "8960.2" "8361.0" "8602.1" "8692.8" "8221.7" "3574.4" "" "" "" "" "" "" "" "" "" "" "7085.5" "6956.2" "7587.9" "6405.3" "7471.6" "7680.5" "7270.1" "7185.2" "7540.5" "3574.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "143.650" "49" "21" "49" "21" "426" "48.6" "5.31" "194.94" "21" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "Protein hydroxylation" "VEGFA-VEGFR2 signaling" "2" "0" "0.951" "0.964" "0.913" "0.905" "0.911" "0.846" "0.915" "0.916" "0.503" "7738.4" "7360.9" "7462.0" "7064.7" "7005.3" "7050.4" "6547.8" "7079.9" "7089.6" "3888.7" "" "" "" "" "" "" "" "" "" "" "6862.2" "6097.4" "6510.9" "5283.4" "5841.5" "6476.6" "5534.0" "5852.0" "6502.2" "3888.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "143.379" "44" "15" "51" "15" "380" "41.8" "8.54" "188.13" "15" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.026" "1.027" "1.041" "1.006" "0.969" "1.036" "1.061" "1.046" "0.534" "4229.0" "4337.4" "4343.9" "4401.9" "4253.7" "4098.1" "4380.0" "4488.0" "4422.4" "2256.6" "" "" "" "" "" "" "" "" "" "" "3750.2" "3592.9" "3790.2" "3292.0" "3547.0" "3764.6" "3701.8" "3709.6" "4055.9" "2256.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "143.193" "44" "14" "44" "14" "369" "40.9" "5.36" "166.19" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "Hypusine synthesis from eIF5A-lysine" "" "1" "0" "0.995" "1.051" "1.007" "1.009" "1.061" "0.948" "0.993" "0.995" "0.574" "4773.9" "4748.1" "5019.2" "4809.5" "4817.1" "5065.9" "4527.2" "4739.8" "4751.3" "2738.7" "" "" "" "" "" "" "" "" "" "" "4233.4" "3933.1" "4379.5" "3596.9" "4016.8" "4653.6" "3826.2" "3917.7" "4357.6" "2738.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "143.066" "38" "16" "34" "15" "452" "50.9" "8.69" "150.59" "16" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.950" "0.975" "0.989" "0.962" "0.939" "0.962" "0.950" "0.928" "0.690" "5005.8" "4753.7" "4880.8" "4952.7" "4817.4" "4698.5" "4817.9" "4757.8" "4643.1" "3452.2" "" "" "" "" "" "" "" "" "" "" "4439.1" "3937.7" "4258.8" "3704.0" "4017.0" "4316.1" "4071.9" "3932.6" "4258.3" "3452.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "142.752" "39" "17" "38" "16" "489" "54.3" "6.83" "151.19" "17" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "Mitochondrial protein import; Processing of SMDT1" "" "2" "1" "0.953" "0.960" "1.042" "1.004" "0.928" "1.108" "1.092" "0.955" "0.975" "3128.4" "2980.2" "3004.4" "3260.1" "3142.1" "2902.0" "3467.0" "3415.3" "2987.4" "3049.3" "" "" "" "" "" "" "" "" "" "" "2774.2" "2468.6" "2621.5" "2438.1" "2620.1" "2665.8" "2930.2" "2823.0" "2739.8" "3049.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "142.324" "37" "12" "38" "12" "407" "43.4" "8.56" "169.82" "12" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.016" "1.070" "1.045" "1.076" "1.071" "0.992" "1.027" "1.032" "0.629" "3500.0" "3555.1" "3743.3" "3656.3" "3764.5" "3748.6" "3471.6" "3594.2" "3610.7" "2202.2" "" "" "" "" "" "" "" "" "" "" "3103.7" "2944.8" "3266.2" "2734.4" "3139.1" "3443.5" "2934.1" "2970.9" "3311.5" "2202.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "142.182" "24" "23" "40" "22" "1151" "130.1" "5.05" "160.36" "23" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "" "eIF5A regulation in response to inhibition of the nuclear export system" "1" "0" "0.997" "0.948" "1.072" "1.006" "1.013" "1.016" "1.032" "0.847" "0.672" "3877.0" "3866.6" "3674.7" "4156.3" "3899.8" "3926.4" "3938.4" "4001.1" "3284.8" "2606.8" "" "" "" "" "" "" "" "" "" "" "3438.0" "3202.9" "3206.3" "3108.3" "3251.9" "3606.8" "3328.5" "3307.2" "3012.6" "2606.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "142.124" "45" "16" "37" "16" "392" "42.2" "6.46" "146.61" "16" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Galactose catabolism; Defective GALK1 causes GALCT2" "Disorders of galactose metabolism" "3" "0" "1.039" "1.049" "1.132" "1.112" "1.078" "1.318" "1.210" "1.151" "1.465" "2922.4" "3037.3" "3065.6" "3308.5" "3250.9" "3150.9" "3852.6" "3536.4" "3365.0" "4282.0" "" "" "" "" "" "" "" "" "" "" "2591.6" "2516.0" "2674.8" "2474.3" "2710.8" "2894.4" "3256.1" "2923.1" "3086.2" "4282.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "141.874" "71" "23" "60" "8" "248" "28.5" "4.69" "206.48" "23" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "Striated muscle contraction pathway" "5" "12" "0.984" "1.008" "0.982" "1.061" "0.973" "0.972" "0.998" "0.971" "0.437" "4555.6" "4484.7" "4592.2" "4474.7" "4831.7" "4434.0" "4428.8" "4548.6" "4422.8" "1991.3" "" "" "" "" "" "" "" "" "" "" "4039.8" "3714.9" "4006.9" "3346.5" "4029.0" "4073.1" "3743.0" "3759.7" "4056.3" "1991.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "141.661" "15" "30" "37" "29" "2115" "238.1" "5.78" "113.14" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "5" "1" "1.007" "0.959" "0.942" "0.932" "0.905" "0.907" "0.709" "0.902" "3.616" "2021.9" "2037.0" "1938.8" "1905.6" "1884.5" "1830.1" "1833.5" "1433.7" "1823.5" "7312.2" "" "" "" "" "" "" "" "" "" "" "1793.0" "1687.4" "1691.7" "1425.1" "1571.4" "1681.2" "1549.6" "1185.1" "1672.4" "7312.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "141.293" "32" "22" "49" "16" "672" "73.6" "8.72" "163.56" "22" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "1.046" "0.975" "1.042" "0.981" "1.008" "0.999" "0.914" "1.019" "2.946" "902.5" "944.3" "880.0" "940.0" "885.2" "909.8" "901.8" "824.5" "920.1" "2659.0" "" "" "" "" "" "" "" "" "" "" "800.3" "782.2" "767.9" "703.0" "738.2" "835.8" "762.2" "681.5" "843.8" "2659.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "141.041" "38" "14" "34" "14" "439" "48.9" "5.29" "139.06" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "0.988" "0.977" "0.981" "0.953" "0.929" "0.923" "1.002" "0.941" "0.307" "6450.2" "6371.9" "6304.5" "6328.6" "6144.8" "5989.1" "5950.5" "6460.3" "6072.8" "1981.3" "" "" "" "" "" "" "" "" "" "" "5719.9" "5278.1" "5501.0" "4733.0" "5123.9" "5501.6" "5029.1" "5339.9" "5569.6" "1981.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "140.979" "61" "14" "43" "14" "311" "33.2" "8.54" "158.85" "14" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "6" "0" "1.005" "0.973" "1.011" "0.978" "1.001" "0.994" "0.973" "0.951" "0.523" "4795.5" "4818.5" "4665.4" "4849.5" "4691.2" "4801.5" "4765.9" "4665.8" "4559.8" "2509.8" "" "" "" "" "" "" "" "" "" "" "4252.5" "3991.4" "4070.8" "3626.8" "3911.9" "4410.8" "4027.9" "3856.6" "4182.0" "2509.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "140.905" "63" "16" "45" "13" "281" "31.1" "5.01" "178.04" "16" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Eukaryotic Translation Elongation" "Translation factors" "2" "3" "0.925" "0.936" "0.884" "0.885" "0.849" "0.873" "0.769" "0.910" "3.076" "3881.0" "3591.2" "3634.5" "3430.1" "3435.7" "3295.7" "3389.0" "2986.0" "3533.5" "11936.4" "" "" "" "" "" "" "" "" "" "" "3441.6" "2974.7" "3171.3" "2565.2" "2864.9" "3027.5" "2864.2" "2468.1" "3240.7" "11936.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "140.882" "41" "17" "42" "16" "483" "54.4" "8.66" "162.59" "17" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "0.994" "0.938" "0.912" "0.912" "0.883" "0.830" "0.851" "0.899" "0.783" "4353.8" "4326.9" "4082.6" "3972.6" "3969.0" "3846.4" "3614.1" "3706.9" "3912.3" "3409.8" "" "" "" "" "" "" "" "" "" "" "3860.9" "3584.2" "3562.3" "2971.0" "3309.6" "3533.4" "3054.5" "3064.0" "3588.2" "3409.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "140.759" "17" "9" "50" "9" "656" "68.4" "9.33" "221.32" "9" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.960" "0.979" "0.983" "0.924" "0.882" "0.891" "1.001" "1.006" "0.568" "7145.1" "6857.2" "6996.8" "7022.6" "6602.4" "6299.5" "6364.9" "7152.0" "7187.9" "4058.4" "" "" "" "" "" "" "" "" "" "" "6336.2" "5680.1" "6105.0" "5252.0" "5505.5" "5786.8" "5379.4" "5911.6" "6592.3" "4058.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "140.615" "70" "14" "42" "14" "242" "27.1" "7.12" "151.41" "14" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Regulation of the apoptosome activity; Methionine salvage pathway" "Methionine de novo and salvage pathway" "4" "0" "1.003" "1.003" "1.021" "1.011" "1.046" "1.057" "1.072" "1.090" "0.552" "4245.4" "4258.2" "4256.7" "4333.8" "4290.3" "4439.6" "4488.3" "4552.2" "4626.9" "2341.6" "" "" "" "" "" "" "" "" "" "" "3764.7" "3527.3" "3714.2" "3241.1" "3577.5" "4078.3" "3793.3" "3762.7" "4243.5" "2341.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "140.591" "27" "26" "34" "26" "1030" "115.2" "5.40" "131.61" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "8" "0" "1.005" "0.991" "0.964" "0.962" "0.963" "0.976" "0.944" "1.010" "2.277" "3438.4" "3456.8" "3409.0" "3314.7" "3306.3" "3311.2" "3354.4" "3245.6" "3471.3" "7829.3" "" "" "" "" "" "" "" "" "" "" "3049.1" "2863.4" "2974.5" "2478.9" "2757.0" "3041.7" "2835.0" "2682.7" "3183.7" "7829.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "140.578" "39" "8" "35" "8" "277" "30.2" "8.09" "138.09" "8" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Mitochondrial protein degradation" "Primary ovarian insufficiency" "2" "0" "1.006" "1.021" "1.040" "1.071" "1.053" "1.004" "1.004" "0.971" "0.446" "3710.6" "3733.6" "3788.1" "3857.8" "3973.1" "3909.0" "3726.6" "3726.6" "3601.8" "1654.2" "" "" "" "" "" "" "" "" "" "" "3290.5" "3092.8" "3305.3" "2885.2" "3313.0" "3590.8" "3149.5" "3080.3" "3303.3" "1654.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "140.254" "27" "29" "40" "29" "1107" "123.6" "7.03" "150.21" "29" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "1.020" "0.972" "1.032" "1.028" "1.065" "0.809" "0.774" "0.801" "1.273" "3758.1" "3834.0" "3653.4" "3878.0" "3864.6" "4001.2" "3040.7" "2908.2" "3012.0" "4784.4" "" "" "" "" "" "" "" "" "" "" "3332.6" "3175.9" "3187.7" "2900.2" "3222.6" "3675.6" "2569.9" "2403.9" "2762.4" "4784.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "140.240" "36" "19" "29" "19" "613" "67.9" "5.40" "127.75" "19" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "" "TYROBP causal network in microglia" "1" "0" "0.992" "1.005" "0.988" "0.991" "1.018" "0.984" "0.963" "0.962" "1.044" "2742.3" "2720.2" "2757.2" "2710.3" "2718.2" "2790.3" "2698.9" "2640.5" "2637.8" "2862.7" "" "" "" "" "" "" "" "" "" "" "2431.8" "2253.3" "2405.8" "2026.9" "2266.6" "2563.2" "2281.0" "2182.5" "2419.3" "2862.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "140.091" "60" "10" "63" "10" "172" "19.8" "4.84" "239.90" "10" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "9" "0" "0.991" "0.974" "1.041" "1.060" "1.027" "1.058" "1.074" "1.087" "0.700" "6101.9" "6046.7" "5946.1" "6349.2" "6469.7" "6267.0" "6454.6" "6550.8" "6631.3" "4269.9" "" "" "" "" "" "" "" "" "" "" "5411.0" "5008.8" "5188.2" "4748.3" "5394.8" "5756.9" "5455.1" "5414.7" "6081.8" "4269.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "139.960" "46" "12" "24" "12" "417" "46.9" "4.54" "119.43" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "Processing of DNA double-strand break ends" "16p11.2 proximal deletion syndrome" "2" "0" "0.986" "0.998" "0.964" "0.926" "1.013" "0.903" "0.963" "0.956" "0.825" "2216.3" "2185.9" "2212.4" "2136.3" "2052.9" "2245.7" "2001.4" "2133.8" "2118.4" "1828.6" "" "" "" "" "" "" "" "" "" "" "1965.4" "1810.7" "1930.4" "1597.7" "1711.9" "2062.9" "1691.5" "1763.8" "1942.8" "1828.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "139.861" "47" "18" "35" "18" "432" "47.6" "5.97" "143.64" "18" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Neutrophil degranulation" "VEGFA-VEGFR2 signaling" "4" "0" "0.989" "1.051" "0.999" "1.016" "1.051" "0.999" "1.045" "1.033" "0.477" "4557.2" "4506.5" "4788.9" "4553.3" "4628.9" "4789.6" "4551.3" "4763.0" "4706.3" "2171.6" "" "" "" "" "" "" "" "" "" "" "4041.2" "3733.0" "4178.6" "3405.3" "3859.8" "4399.8" "3846.6" "3937.0" "4316.3" "2171.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "139.789" "53" "14" "33" "14" "321" "34.0" "6.14" "126.51" "14" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "Glycolysis" "" "1" "0" "1.057" "1.025" "1.125" "1.114" "1.066" "1.058" "1.096" "0.946" "0.576" "2663.8" "2814.5" "2730.2" "2996.7" "2968.1" "2840.6" "2818.0" "2920.7" "2519.2" "1535.2" "" "" "" "" "" "" "" "" "" "" "2362.2" "2331.4" "2382.2" "2241.1" "2475.0" "2609.4" "2381.7" "2414.2" "2310.5" "1535.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "139.669" "52" "13" "43" "13" "227" "24.6" "7.21" "171.95" "13" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Protein repair" "Primary ovarian insufficiency" "2" "0" "0.983" "1.014" "0.986" "0.986" "1.024" "1.017" "1.000" "1.022" "0.517" "4982.2" "4897.0" "5052.7" "4914.3" "4913.5" "5101.4" "5067.8" "4980.8" "5094.1" "2576.3" "" "" "" "" "" "" "" "" "" "" "4418.1" "4056.4" "4408.7" "3675.2" "4097.2" "4686.2" "4283.1" "4117.0" "4672.0" "2576.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8722067118007621165" "False" "High" "IsMasterProtein" "P23497" "Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3" "0.000" "False" "139.622" "26" "20" "34" "13" "879" "100.4" "8.22" "118.85" "20" "cell organization and biogenesis;DNA metabolism;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01342, Pf03172, Pf09011" "6672" "ENSG00000067066" "SP100" "B4DDX5; B8ZZD8; E7EUA7; E9PH61; F8WFE2; hsa:6672; O75450; P23497; Q13343; Q8TE34; Q96F70; Q96T24; Q96T95; Q9NP33; Q9UE32" "SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling" "" "2" "6" "0.880" "0.900" "0.832" "0.958" "0.856" "0.729" "0.775" "0.787" "0.592" "4636.7" "4080.0" "4171.9" "3859.4" "4444.2" "3969.0" "3380.5" "3595.1" "3648.5" "2744.8" "" "" "" "" "" "" "" "" "" "" "4111.7" "3379.6" "3640.2" "2886.3" "3705.8" "3646.0" "2857.1" "2971.6" "3346.2" "2744.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "139.562" "37" "13" "49" "13" "437" "49.0" "5.71" "187.56" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "Translation factors" "6" "0" "0.951" "0.972" "1.009" "0.963" "0.924" "1.074" "1.037" "0.914" "1.007" "6537.2" "6216.2" "6355.0" "6598.0" "6293.3" "6039.0" "7023.1" "6780.0" "5975.2" "6584.3" "" "" "" "" "" "" "" "" "" "" "5797.0" "5149.2" "5545.1" "4934.5" "5247.7" "5547.5" "5935.7" "5604.2" "5480.1" "6584.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "High" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.000" "False" "138.779" "12" "39" "40" "39" "3056" "350.5" "6.81" "130.47" "39" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Sensing of DNA Double Strand Breaks; Pexophagy" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "54" "0" "1.006" "0.993" "0.998" "0.962" "0.965" "0.964" "0.958" "0.919" "0.933" "3267.6" "3288.7" "3246.0" "3262.1" "3144.9" "3152.2" "3148.7" "3131.7" "3001.3" "3047.9" "" "" "" "" "" "" "" "" "" "" "2897.6" "2724.2" "2832.3" "2439.7" "2622.4" "2895.6" "2661.2" "2588.5" "2752.6" "3047.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "138.757" "28" "38" "49" "38" "1382" "166.5" "6.79" "155.09" "38" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "9" "0" "0.973" "0.900" "0.934" "0.914" "0.883" "0.940" "0.718" "0.918" "4.198" "2703.6" "2631.2" "2433.0" "2526.2" "2471.6" "2386.9" "2541.8" "1942.2" "2483.3" "11350.5" "" "" "" "" "" "" "" "" "" "" "2397.5" "2179.6" "2122.9" "1889.3" "2061.0" "2192.7" "2148.3" "1605.3" "2277.5" "11350.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "138.504" "43" "20" "43" "20" "431" "49.2" "5.58" "135.57" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "4" "0" "0.992" "0.993" "0.908" "0.913" "0.997" "0.844" "0.877" "0.913" "1.261" "5339.0" "5294.6" "5302.6" "4845.2" "4874.4" "5320.8" "4505.7" "4684.4" "4876.2" "6732.9" "" "" "" "" "" "" "" "" "" "" "4734.5" "4385.7" "4626.7" "3623.6" "4064.6" "4887.7" "3808.1" "3872.0" "4472.1" "6732.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142144855289123481" "False" "High" "IsMasterProtein" "Q96HC4" "PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5" "0.000" "False" "138.504" "37" "18" "28" "18" "596" "63.9" "8.21" "115.65" "18" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "10611" "ENSG00000163110" "PDLIM5" "A8K6F9; D6RB78; E9PBF5; hsa:10611; O60705; Q56VN4; Q5UW38; Q8WVK0; Q96HC4" "Neurexins and neuroligins" "Extracellular vesicles in the crosstalk of cardiac cells" "2" "0" "0.961" "0.989" "0.938" "0.922" "0.893" "0.891" "0.975" "0.992" "0.659" "2007.7" "1930.0" "1986.5" "1883.6" "1850.7" "1793.1" "1789.2" "1957.3" "1992.2" "1322.5" "" "" "" "" "" "" "" "" "" "" "1780.4" "1598.7" "1733.3" "1408.7" "1543.2" "1647.2" "1512.1" "1617.8" "1827.2" "1322.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "138.412" "30" "14" "39" "12" "471" "54.2" "8.95" "146.17" "14" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "" "mRNA processing" "1" "0" "1.015" "0.964" "1.016" "0.998" "0.967" "0.924" "0.563" "0.957" "8.387" "1702.2" "1728.0" "1640.8" "1729.2" "1699.5" "1645.7" "1573.6" "959.0" "1628.6" "14276.0" "" "" "" "" "" "" "" "" "" "" "1509.4" "1431.4" "1431.7" "1293.2" "1417.2" "1511.7" "1329.9" "792.7" "1493.6" "14276.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "138.281" "46" "12" "36" "12" "307" "33.7" "8.21" "145.12" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "" "Fatty acid biosynthesis" "1" "0" "1.030" "1.019" "1.043" "1.045" "1.085" "1.056" "1.103" "1.057" "0.477" "4027.1" "4149.9" "4102.2" "4200.4" "4206.7" "4368.3" "4254.4" "4440.3" "4255.2" "1922.2" "" "" "" "" "" "" "" "" "" "" "3571.2" "3437.6" "3579.4" "3141.4" "3507.8" "4012.7" "3595.6" "3670.2" "3902.6" "1922.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "138.056" "31" "22" "31" "22" "814" "92.4" "5.00" "128.78" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.957" "0.919" "0.944" "0.915" "0.890" "0.996" "0.802" "0.927" "3.873" "2981.1" "2852.6" "2740.9" "2814.8" "2728.6" "2653.5" "2970.5" "2390.3" "2764.0" "11545.3" "" "" "" "" "" "" "" "" "" "" "2643.5" "2362.9" "2391.6" "2105.1" "2275.3" "2437.6" "2510.5" "1975.7" "2535.0" "11545.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "137.932" "45" "14" "29" "14" "416" "44.5" "5.40" "142.27" "14" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "0.947" "0.934" "0.945" "0.909" "0.981" "0.815" "0.896" "0.885" "0.459" "3444.3" "3261.3" "3215.3" "3255.4" "3132.0" "3379.6" "2806.1" "3086.5" "3048.1" "1582.0" "" "" "" "" "" "" "" "" "" "" "3054.3" "2701.5" "2805.5" "2434.6" "2611.6" "3104.6" "2371.6" "2551.2" "2795.5" "1582.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "137.893" "26" "27" "38" "27" "1019" "117.9" "6.61" "133.68" "27" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "5" "0" "0.983" "0.958" "1.018" "0.998" "0.957" "1.024" "0.901" "0.891" "2.574" "3656.3" "3593.5" "3503.7" "3723.9" "3649.8" "3499.6" "3743.7" "3296.1" "3256.1" "9412.7" "" "" "" "" "" "" "" "" "" "" "3242.3" "2976.7" "3057.2" "2785.0" "3043.4" "3214.8" "3164.0" "2724.4" "2986.3" "9412.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "137.591" "34" "16" "45" "16" "517" "57.4" "6.76" "168.81" "16" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Purine ribonucleoside monophosphate biosynthesis" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "3" "0" "1.042" "1.028" "1.081" "1.053" "1.061" "1.067" "1.072" "0.999" "0.518" "5227.6" "5447.4" "5371.4" "5652.5" "5505.9" "5545.9" "5576.3" "5604.3" "5220.4" "2709.1" "" "" "" "" "" "" "" "" "" "" "4635.7" "4512.4" "4686.8" "4227.3" "4591.2" "5094.5" "4712.9" "4632.4" "4787.8" "2709.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "137.525" "82" "12" "110" "2" "152" "17.3" "8.41" "376.69" "12" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Neutrophil degranulation; Azathioprine ADME; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "Pyrimidine metabolism" "5" "12" "0.970" "1.019" "0.965" "1.012" "0.992" "0.948" "0.995" "1.029" "0.509" "13460.0" "13060.5" "13712.5" "12995.0" "13616.7" "13354.5" "12755.9" "13389.4" "13845.0" "6854.5" "" "" "" "" "" "" "" "" "" "" "11936.1" "10818.6" "11964.8" "9718.5" "11354.5" "12267.6" "10780.7" "11067.3" "12697.8" "6854.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "137.257" "51" "16" "38" "16" "353" "39.3" "7.88" "145.72" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "rRNA modification in the nucleus and cytosol" "" "1" "0" "1.032" "1.063" "1.022" "1.018" "1.061" "1.047" "1.051" "1.034" "0.548" "4225.3" "4362.2" "4492.8" "4316.1" "4303.1" "4484.5" "4423.5" "4440.6" "4371.0" "2313.7" "" "" "" "" "" "" "" "" "" "" "3746.9" "3613.4" "3920.2" "3227.9" "3588.2" "4119.5" "3738.6" "3670.5" "4008.8" "2313.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "136.823" "43" "13" "40" "13" "362" "40.5" "6.70" "170.07" "13" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Ribavirin ADME; Purine salvage" "Methionine metabolism leading to sulfur amino acids and related disorders" "3" "0" "1.031" "1.049" "1.068" "1.082" "1.078" "1.045" "1.092" "1.048" "0.544" "4126.3" "4252.4" "4328.5" "4408.6" "4465.9" "4448.1" "4313.9" "4507.0" "4324.0" "2243.0" "" "" "" "" "" "" "" "" "" "" "3659.1" "3522.5" "3776.8" "3297.0" "3723.9" "4086.0" "3645.9" "3725.3" "3965.7" "2243.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "136.803" "47" "11" "42" "11" "276" "30.3" "7.43" "157.41" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "Proteasome degradation; Immune response to tuberculosis" "62" "0" "1.018" "1.041" "0.985" "1.101" "1.079" "1.058" "1.053" "1.009" "0.569" "3689.6" "3756.2" "3842.5" "3634.4" "4063.6" "3979.8" "3902.7" "3884.8" "3723.4" "2100.1" "" "" "" "" "" "" "" "" "" "" "3271.9" "3111.4" "3352.8" "2718.0" "3388.5" "3655.9" "3298.4" "3211.0" "3414.9" "2100.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "136.692" "39" "24" "30" "24" "660" "75.3" "6.68" "119.67" "24" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Amino acid metabolism" "3" "0" "1.023" "0.964" "1.107" "1.020" "0.991" "1.146" "0.391" "1.116" "13.587" "1191.2" "1218.7" "1148.0" "1318.8" "1214.8" "1181.0" "1364.9" "465.3" "1329.0" "16184.9" "" "" "" "" "" "" "" "" "" "" "1056.3" "1009.5" "1001.7" "986.3" "1013.0" "1084.9" "1153.5" "384.6" "1218.8" "16184.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "136.563" "78" "13" "54" "13" "163" "18.6" "4.54" "218.70" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "Nuclear events stimulated by ALK signaling in cancer; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "39" "0" "1.002" "1.020" "1.012" "0.956" "1.000" "1.034" "1.059" "1.031" "0.476" "5197.0" "5205.5" "5300.7" "5261.7" "4967.5" "5198.6" "5372.2" "5504.4" "5358.3" "2474.3" "" "" "" "" "" "" "" "" "" "" "4608.6" "4312.0" "4625.1" "3935.1" "4142.2" "4775.5" "4540.4" "4549.8" "4914.3" "2474.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "136.552" "42" "11" "30" "11" "412" "45.5" "7.11" "151.42" "11" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.069" "1.099" "1.063" "1.125" "1.121" "1.065" "1.102" "1.005" "0.609" "3352.4" "3582.8" "3684.7" "3564.2" "3771.0" "3758.3" "3571.7" "3696.0" "3369.9" "2043.3" "" "" "" "" "" "" "" "" "" "" "2972.9" "2967.8" "3215.1" "2665.6" "3144.5" "3452.4" "3018.7" "3055.0" "3090.7" "2043.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6612546022737726869" "False" "High" "IsMasterProtein" "P80303" "Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3" "0.000" "False" "136.411" "49" "17" "31" "17" "420" "50.2" "5.12" "118.71" "17" "signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13499" "4925" "ENSG00000070081" "NUCB2" "A8K642; D3DQX5; hsa:4925; P80303; Q8NFT5; V9HW75" "" "" "0" "0" "1.027" "0.998" "0.955" "0.973" "1.027" "0.744" "0.861" "0.915" "0.525" "3542.6" "3637.8" "3536.3" "3382.1" "3448.3" "3638.0" "2636.5" "3051.1" "3243.1" "1859.9" "" "" "" "" "" "" "" "" "" "" "3141.5" "3013.4" "3085.6" "2529.4" "2875.4" "3341.9" "2228.3" "2522.0" "2974.4" "1859.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "136.194" "55" "15" "34" "15" "348" "37.9" "7.23" "132.60" "15" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "Purine salvage" "" "1" "0" "0.997" "1.024" "1.016" "1.026" "1.054" "1.005" "1.024" "0.979" "0.485" "2761.0" "2751.6" "2827.3" "2805.3" "2832.5" "2909.4" "2776.0" "2827.8" "2702.6" "1339.5" "" "" "" "" "" "" "" "" "" "" "2448.4" "2279.3" "2466.9" "2098.0" "2362.0" "2672.6" "2346.2" "2337.4" "2478.7" "1339.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "136.130" "51" "14" "42" "14" "277" "30.2" "5.26" "173.41" "14" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "Synthesis of IP2, IP, and Ins in the cytosol" "" "1" "0" "0.974" "1.034" "0.988" "1.030" "1.056" "1.000" "1.035" "1.044" "0.515" "4883.3" "4755.4" "5049.4" "4827.1" "5029.4" "5155.8" "4884.3" "5053.3" "5099.7" "2513.0" "" "" "" "" "" "" "" "" "" "" "4330.4" "3939.1" "4405.8" "3610.0" "4193.8" "4736.2" "4128.0" "4176.9" "4677.1" "2513.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "136.095" "26" "23" "41" "12" "953" "107.4" "6.16" "155.03" "23" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "0" "0.948" "0.838" "0.893" "0.825" "0.768" "0.805" "0.867" "0.909" "1.162" "1581.4" "1498.6" "1325.3" "1411.9" "1304.0" "1214.9" "1273.1" "1370.9" "1437.2" "1836.8" "" "" "" "" "" "" "" "" "" "" "1402.3" "1241.3" "1156.4" "1055.9" "1087.4" "1116.0" "1075.9" "1133.2" "1318.1" "1836.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "135.972" "37" "12" "32" "12" "412" "44.5" "6.54" "123.42" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "8" "0" "1.044" "1.067" "1.069" "1.096" "1.104" "1.054" "1.078" "1.005" "0.771" "2561.3" "2673.9" "2734.0" "2738.1" "2806.7" "2828.0" "2698.3" "2761.1" "2573.8" "1974.1" "" "" "" "" "" "" "" "" "" "" "2271.3" "2214.9" "2385.5" "2047.7" "2340.4" "2597.8" "2280.5" "2282.2" "2360.5" "1974.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "135.920" "51" "10" "44" "10" "239" "27.6" "4.84" "176.91" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "1.020" "1.011" "1.032" "1.035" "1.032" "1.011" "1.039" "1.008" "0.511" "4110.1" "4194.3" "4154.3" "4240.5" "4253.4" "4241.1" "4153.6" "4269.9" "4142.1" "2100.2" "" "" "" "" "" "" "" "" "" "" "3644.8" "3474.3" "3624.8" "3171.3" "3546.8" "3895.9" "3510.4" "3529.4" "3798.9" "2100.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "135.894" "48" "16" "49" "16" "366" "39.6" "6.92" "178.92" "16" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "5" "0" "0.965" "0.978" "0.970" "0.949" "0.902" "0.972" "1.013" "0.949" "0.500" "8025.3" "7744.1" "7850.8" "7786.4" "7617.4" "7238.8" "7800.4" "8127.4" "7618.3" "4012.5" "" "" "" "" "" "" "" "" "" "" "7116.7" "6414.8" "6850.2" "5823.2" "6351.9" "6649.6" "6592.6" "6717.9" "6987.0" "4012.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2438255133986472284" "False" "High" "IsMasterProtein" "Q9H8H0" "Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1" "0.000" "False" "135.804" "31" "20" "44" "20" "719" "81.1" "6.07" "158.71" "20" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf08168, Pf20998" "25926" "ENSG00000130935" "NOL11" "B7Z5V9; hsa:25926; Q7L5S1; Q9H8H0; Q9UG18" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.012" "1.012" "1.060" "1.013" "1.012" "1.028" "1.038" "0.953" "0.275" "4391.1" "4444.9" "4445.7" "4655.1" "4447.2" "4442.4" "4513.7" "4556.1" "4186.3" "1205.7" "" "" "" "" "" "" "" "" "" "" "3893.9" "3681.9" "3879.1" "3481.4" "3708.3" "4080.8" "3814.8" "3765.9" "3839.4" "1205.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "135.724" "46" "11" "38" "11" "263" "28.5" "6.92" "154.87" "11" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Asymmetric localization of PCP proteins; Degradation of DVL; ER-Phagosome pathway; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.007" "1.030" "1.003" "1.086" "1.070" "1.026" "1.040" "0.969" "0.547" "3630.0" "3656.3" "3737.4" "3642.6" "3940.5" "3885.4" "3723.0" "3774.7" "3516.2" "1986.9" "" "" "" "" "" "" "" "" "" "" "3219.0" "3028.7" "3261.1" "2724.2" "3285.9" "3569.2" "3146.5" "3120.0" "3224.9" "1986.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "135.516" "62" "17" "31" "17" "317" "35.1" "7.69" "145.71" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "10" "0" "0.985" "0.949" "1.003" "1.077" "1.013" "0.916" "0.865" "0.858" "1.121" "3659.8" "3606.0" "3472.0" "3669.2" "3943.1" "3708.5" "3352.1" "3164.2" "3139.3" "4102.6" "" "" "" "" "" "" "" "" "" "" "3245.4" "2987.0" "3029.5" "2744.1" "3288.0" "3406.7" "2833.1" "2615.5" "2879.2" "4102.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "135.347" "10" "22" "25" "22" "2813" "307.4" "5.24" "98.64" "22" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "8" "0" "0.986" "1.000" "1.062" "1.039" "1.004" "0.895" "0.873" "0.924" "0.895" "1061.9" "1046.6" "1062.2" "1127.7" "1102.9" "1065.7" "950.1" "927.0" "981.5" "950.4" "" "" "" "" "" "" "" "" "" "" "941.7" "866.9" "926.8" "843.4" "919.7" "979.0" "803.0" "766.2" "900.2" "950.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.000" "False" "135.206" "51" "15" "38" "15" "366" "39.3" "7.85" "136.86" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "1.018" "0.963" "1.039" "0.946" "0.900" "0.914" "0.982" "0.907" "0.540" "3009.1" "3062.6" "2897.5" "3125.5" "2847.1" "2708.1" "2751.1" "2956.0" "2730.7" "1625.2" "" "" "" "" "" "" "" "" "" "" "2668.4" "2536.9" "2528.2" "2337.4" "2374.1" "2487.7" "2325.1" "2443.3" "2504.4" "1625.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "135.044" "34" "19" "31" "19" "594" "67.2" "5.96" "116.96" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "1.009" "0.986" "1.013" "1.023" "1.040" "1.038" "1.047" "0.987" "0.919" "3528.3" "3559.1" "3479.3" "3574.0" "3609.8" "3668.3" "3663.4" "3694.6" "3482.0" "3243.5" "" "" "" "" "" "" "" "" "" "" "3128.8" "2948.2" "3035.8" "2672.9" "3010.1" "3369.7" "3096.1" "3053.8" "3193.5" "3243.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "134.934" "76" "14" "88" "14" "154" "15.9" "6.13" "353.01" "14" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "17" "0" "0.965" "1.011" "1.074" "1.041" "0.903" "0.875" "1.073" "1.023" "0.516" "8146.4" "7864.5" "8232.7" "8747.1" "8482.6" "7354.2" "7125.9" "8744.6" "8337.7" "4201.5" "" "" "" "" "" "" "" "" "" "" "7224.0" "6514.6" "7183.4" "6541.7" "7073.3" "6755.6" "6022.6" "7228.0" "7646.8" "4201.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "134.811" "20" "11" "60" "11" "639" "68.3" "8.98" "239.27" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "mRNA Splicing - Major Pathway" "" "1" "0" "0.970" "0.985" "0.969" "0.940" "0.997" "0.937" "0.941" "0.919" "0.464" "9063.2" "8787.7" "8930.8" "8779.8" "8516.0" "9039.2" "8490.6" "8530.3" "8324.8" "4207.5" "" "" "" "" "" "" "" "" "" "" "8037.1" "7279.3" "7792.6" "6566.1" "7101.1" "8303.5" "7175.9" "7050.9" "7634.9" "4207.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "134.786" "55" "10" "89" "10" "149" "16.8" "4.22" "343.11" "10" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "17" "0" "1.003" "0.942" "1.020" "1.014" "1.094" "0.978" "0.991" "1.007" "0.613" "9672.5" "9705.6" "9109.7" "9864.6" "9806.1" "10578.3" "9460.3" "9585.5" "9744.0" "5924.6" "" "" "" "" "" "" "" "" "" "" "8577.4" "8039.6" "7948.6" "7377.4" "8177.0" "9717.3" "7995.5" "7923.1" "8936.5" "5924.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "134.660" "52" "10" "41" "10" "223" "24.7" "6.95" "155.28" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "63" "0" "0.970" "0.934" "0.911" "0.890" "0.908" "0.862" "0.913" "0.971" "0.688" "4441.7" "4307.6" "4146.6" "4048.3" "3954.4" "4031.1" "3826.9" "4055.3" "4314.9" "3056.1" "" "" "" "" "" "" "" "" "" "" "3938.8" "3568.2" "3618.1" "3027.6" "3297.5" "3703.0" "3234.3" "3352.0" "3957.4" "3056.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "134.567" "58" "12" "44" "12" "261" "29.0" "7.31" "160.37" "12" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "0.975" "1.020" "0.938" "0.985" "1.021" "1.011" "1.017" "1.041" "0.494" "5855.1" "5709.8" "5970.7" "5489.5" "5768.0" "5978.3" "5918.5" "5953.9" "6097.4" "2891.3" "" "" "" "" "" "" "" "" "" "" "5192.2" "4729.7" "5209.7" "4105.4" "4809.7" "5491.7" "5002.1" "4921.3" "5592.2" "2891.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "134.257" "41" "18" "37" "18" "557" "64.1" "5.08" "138.80" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "PKR-mediated signaling; ISG15 antiviral mechanism; RSV-host interactions" "" "3" "0" "1.026" "1.042" "0.990" "1.024" "1.056" "1.017" "1.045" "1.023" "0.571" "2872.6" "2947.9" "2992.2" "2844.7" "2942.9" "3034.0" "2920.1" "3001.6" "2939.0" "1640.1" "" "" "" "" "" "" "" "" "" "" "2547.4" "2441.9" "2610.8" "2127.5" "2453.9" "2787.1" "2468.0" "2481.0" "2695.5" "1640.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "High" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.000" "False" "134.239" "42" "16" "30" "16" "483" "55.8" "6.48" "122.99" "16" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "Nef Mediated CD4 Down-regulation; ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "Proximal tubule transport" "9" "0" "1.022" "0.993" "1.011" "1.015" "0.967" "1.033" "1.033" "0.999" "0.789" "3210.4" "3281.4" "3189.0" "3245.1" "3258.7" "3105.6" "3317.7" "3317.9" "3208.7" "2533.7" "" "" "" "" "" "" "" "" "" "" "2846.9" "2718.1" "2782.6" "2426.9" "2717.3" "2852.8" "2804.0" "2742.5" "2942.8" "2533.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "134.183" "50" "19" "83" "19" "334" "36.4" "7.36" "263.67" "19" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Gluconeogenesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "10" "0" "0.997" "0.987" "0.984" "0.997" "0.976" "0.986" "0.996" "0.950" "0.472" "8901.1" "8870.7" "8784.8" "8757.1" "8878.2" "8685.5" "8778.1" "8862.4" "8458.7" "4204.7" "" "" "" "" "" "" "" "" "" "" "7893.3" "7348.0" "7665.2" "6549.1" "7403.2" "7978.6" "7418.9" "7325.4" "7757.8" "4204.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "134.106" "55" "18" "36" "15" "389" "44.8" "5.38" "129.16" "18" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "8" "4" "1.243" "1.105" "1.224" "1.219" "1.122" "1.598" "1.500" "1.491" "0.795" "2402.5" "2985.7" "2653.9" "2939.5" "2929.1" "2695.4" "3840.3" "3604.1" "3580.9" "1908.9" "" "" "" "" "" "" "" "" "" "" "2130.5" "2473.2" "2315.7" "2198.3" "2442.5" "2476.0" "3245.7" "2979.0" "3284.2" "1908.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "134.014" "49" "20" "29" "19" "432" "46.5" "6.39" "119.14" "20" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "5" "1" "0.892" "0.950" "0.997" "1.013" "1.024" "1.368" "1.328" "1.285" "1.317" "3460.8" "3087.6" "3289.3" "3449.1" "3506.0" "3542.3" "4733.7" "4596.2" "4448.8" "4558.2" "" "" "" "" "" "" "" "" "" "" "3069.0" "2557.6" "2870.1" "2579.5" "2923.5" "3254.0" "4000.8" "3799.1" "4080.1" "4558.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "133.933" "30" "14" "31" "14" "582" "63.8" "9.32" "145.27" "14" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "3" "0" "1.025" "1.026" "1.009" "0.998" "1.013" "0.994" "1.039" "1.001" "0.327" "3956.7" "4057.0" "4057.7" "3990.7" "3948.9" "4008.4" "3932.6" "4111.2" "3961.9" "1292.9" "" "" "" "" "" "" "" "" "" "" "3508.7" "3360.7" "3540.5" "2984.5" "3292.9" "3682.1" "3323.7" "3398.2" "3633.6" "1292.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "133.045" "34" "15" "36" "15" "493" "54.5" "6.00" "155.30" "15" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "1.046" "1.047" "1.058" "1.014" "0.994" "1.059" "1.032" "1.014" "0.550" "4373.7" "4575.1" "4579.8" "4629.1" "4433.3" "4345.9" "4632.1" "4513.3" "4432.7" "2407.1" "" "" "" "" "" "" "" "" "" "" "3878.5" "3789.8" "3996.1" "3461.9" "3696.8" "3992.1" "3914.9" "3730.6" "4065.4" "2407.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "133.037" "36" "22" "28" "22" "742" "82.8" "5.10" "121.01" "22" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "0.979" "0.955" "0.926" "0.900" "0.971" "0.861" "0.876" "0.913" "1.183" "3599.0" "3524.6" "3438.1" "3332.6" "3237.7" "3495.1" "3100.1" "3152.8" "3286.1" "4259.3" "" "" "" "" "" "" "" "" "" "" "3191.5" "2919.6" "2999.9" "2492.4" "2699.8" "3210.6" "2620.1" "2606.0" "3013.8" "4259.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "132.849" "40" "10" "89" "10" "290" "33.5" "4.32" "349.44" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "Histone modifications; VEGFA-VEGFR2 signaling" "4" "0" "1.037" "1.040" "0.969" "1.023" "0.972" "0.964" "1.056" "1.025" "0.585" "10011.5" "10377.3" "10408.3" "9703.6" "10241.9" "9726.7" "9652.5" "10574.5" "10264.4" "5852.7" "" "" "" "" "" "" "" "" "" "" "8878.0" "8596.0" "9081.8" "7257.0" "8540.4" "8935.1" "8157.9" "8740.6" "9413.8" "5852.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "132.617" "25" "24" "37" "24" "1034" "117.1" "7.87" "127.49" "24" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "0.971" "0.954" "0.935" "0.888" "0.850" "0.822" "0.870" "0.896" "0.587" "3601.9" "3498.3" "3435.8" "3368.4" "3197.6" "3061.2" "2961.1" "3132.5" "3226.7" "2114.6" "" "" "" "" "" "" "" "" "" "" "3194.1" "2897.8" "2997.9" "2519.1" "2666.4" "2812.0" "2502.6" "2589.2" "2959.4" "2114.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "132.556" "43" "15" "21" "15" "457" "50.2" "8.31" "92.74" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "" "Iron-sulfur cluster biogenesis" "1" "0" "1.049" "1.075" "1.067" "1.080" "1.086" "1.053" "1.077" "0.982" "0.518" "2766.8" "2903.5" "2975.0" "2951.0" "2988.3" "3005.7" "2914.2" "2979.5" "2717.5" "1432.9" "" "" "" "" "" "" "" "" "" "" "2453.5" "2405.1" "2595.8" "2207.0" "2491.8" "2761.1" "2463.0" "2462.8" "2492.3" "1432.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.000" "False" "132.347" "11" "30" "30" "30" "2620" "294.2" "6.14" "111.14" "30" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "Ub-specific processing proteases" "" "1" "0" "1.022" "0.948" "1.065" "1.047" "1.012" "1.118" "1.042" "1.008" "1.830" "2366.2" "2419.4" "2244.0" "2520.7" "2478.5" "2393.9" "2644.5" "2465.7" "2386.3" "4330.9" "" "" "" "" "" "" "" "" "" "" "2098.3" "2004.1" "1958.0" "1885.2" "2066.7" "2199.1" "2235.0" "2038.1" "2188.6" "4330.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "132.088" "39" "18" "42" "18" "508" "56.9" "8.15" "160.51" "18" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "5" "0" "1.007" "1.027" "1.053" "1.058" "1.060" "1.022" "1.051" "0.981" "0.507" "4907.8" "4941.8" "5041.6" "5169.1" "5190.7" "5201.3" "5017.5" "5157.4" "4815.6" "2488.4" "" "" "" "" "" "" "" "" "" "" "4352.2" "4093.6" "4399.1" "3865.8" "4328.3" "4777.9" "4240.6" "4263.0" "4416.6" "2488.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "131.922" "39" "17" "38" "17" "443" "51.6" "5.53" "138.68" "17" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "Ciliary landscape" "6" "0" "0.990" "1.044" "0.975" "1.032" "1.044" "1.007" "1.025" "0.979" "0.528" "4545.7" "4500.7" "4744.8" "4430.1" "4690.5" "4746.8" "4578.3" "4659.5" "4449.4" "2400.7" "" "" "" "" "" "" "" "" "" "" "4031.0" "3728.1" "4140.0" "3313.1" "3911.3" "4360.5" "3869.4" "3851.4" "4080.7" "2400.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "131.839" "42" "12" "29" "12" "400" "43.4" "5.10" "129.50" "12" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "COPII-mediated vesicle transport; Signaling by ALK fusions and activated point mutants" "" "2" "0" "1.084" "1.098" "1.189" "1.128" "1.005" "1.008" "1.160" "1.105" "0.604" "2479.6" "2688.9" "2722.7" "2949.0" "2796.0" "2492.7" "2500.2" "2875.4" "2740.5" "1498.4" "" "" "" "" "" "" "" "" "" "" "2198.8" "2227.3" "2375.7" "2205.5" "2331.4" "2289.9" "2113.0" "2376.7" "2513.4" "1498.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "131.764" "51" "21" "72" "7" "285" "32.9" "4.72" "226.97" "21" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "7" "3" "0.968" "0.930" "1.002" "0.957" "0.942" "0.973" "0.977" "0.976" "0.886" "3459.6" "3347.8" "3215.9" "3466.3" "3312.0" "3260.4" "3366.9" "3379.2" "3378.1" "3065.7" "" "" "" "" "" "" "" "" "" "" "3067.9" "2773.2" "2806.0" "2592.3" "2761.7" "2995.0" "2845.6" "2793.2" "3098.2" "3065.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "131.680" "58" "11" "31" "9" "286" "32.9" "5.85" "155.62" "11" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "7" "2" "1.024" "0.958" "0.956" "0.972" "0.984" "1.120" "0.996" "0.977" "0.653" "2202.5" "2255.2" "2109.8" "2106.4" "2139.9" "2168.0" "2467.7" "2193.6" "2151.4" "1437.3" "" "" "" "" "" "" "" "" "" "" "1953.1" "1868.1" "1840.9" "1575.3" "1784.4" "1991.6" "2085.6" "1813.2" "1973.1" "1437.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "131.560" "35" "18" "29" "18" "587" "63.5" "4.68" "118.46" "18" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "12" "0" "0.995" "0.963" "1.035" "0.973" "0.995" "1.012" "0.852" "0.964" "3.074" "2960.9" "2946.1" "2852.2" "3065.6" "2880.8" "2946.0" "2996.1" "2521.4" "2853.2" "9100.2" "" "" "" "" "" "" "" "" "" "" "2625.6" "2440.4" "2488.7" "2292.7" "2402.2" "2706.2" "2532.2" "2084.1" "2616.8" "9100.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "131.539" "38" "12" "33" "5" "449" "49.2" "6.30" "136.19" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "6" "6" "1.054" "1.063" "1.026" "1.041" "0.986" "1.082" "0.574" "0.964" "10.186" "1554.5" "1639.0" "1652.0" "1595.7" "1618.8" "1532.6" "1681.9" "892.4" "1498.8" "15834.9" "" "" "" "" "" "" "" "" "" "" "1378.5" "1357.6" "1441.5" "1193.3" "1349.9" "1407.9" "1421.5" "737.6" "1374.6" "15834.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "131.355" "27" "14" "38" "14" "584" "65.4" "7.61" "155.82" "14" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle in senescence" "3" "0" "1.117" "1.105" "1.056" "1.121" "1.181" "1.048" "1.046" "1.016" "0.620" "4566.9" "5101.9" "5045.4" "4824.8" "5119.2" "5395.5" "4784.4" "4778.3" "4639.9" "2830.5" "" "" "" "" "" "" "" "" "" "" "4049.8" "4226.1" "4402.4" "3608.3" "4268.7" "4956.3" "4043.6" "3949.6" "4255.5" "2830.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "131.032" "30" "14" "42" "11" "601" "63.8" "5.22" "164.06" "14" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "3" "1.072" "1.045" "1.041" "1.131" "1.076" "1.092" "1.043" "1.052" "0.718" "2487.6" "2666.1" "2598.5" "2590.6" "2812.5" "2677.5" "2716.6" "2594.9" "2617.8" "1786.9" "" "" "" "" "" "" "" "" "" "" "2205.9" "2208.4" "2267.3" "1937.4" "2345.3" "2459.5" "2296.0" "2144.9" "2400.9" "1786.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "131.030" "23" "19" "34" "17" "871" "97.6" "5.81" "142.79" "19" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "" "2" "0" "1.042" "1.012" "1.008" "1.011" "1.020" "0.971" "0.993" "0.901" "0.938" "3529.6" "3679.4" "3570.4" "3558.2" "3569.1" "3601.2" "3427.7" "3503.2" "3180.0" "3309.3" "" "" "" "" "" "" "" "" "" "" "3130.0" "3047.8" "3115.3" "2661.1" "2976.1" "3308.1" "2897.0" "2895.6" "2916.5" "3309.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "130.856" "58" "14" "74" "14" "249" "28.7" "6.02" "282.77" "14" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Antigen processing: Ubiquitination & Proteasome degradation; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "1.000" "1.002" "0.979" "1.002" "1.042" "0.983" "1.026" "1.047" "0.504" "9568.7" "9571.0" "9587.1" "9364.8" "9586.2" "9974.4" "9407.1" "9819.0" "10014.4" "4823.7" "" "" "" "" "" "" "" "" "" "" "8485.4" "7928.1" "8365.2" "7003.6" "7993.6" "9162.6" "7950.5" "8116.1" "9184.5" "4823.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "130.057" "30" "25" "49" "24" "825" "94.8" "6.55" "174.46" "25" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "Purine salvage" "" "1" "1" "1.032" "1.052" "1.046" "1.065" "1.050" "1.053" "1.077" "1.019" "0.568" "4735.8" "4885.4" "4981.7" "4953.8" "5041.7" "4974.2" "4986.1" "5099.4" "4826.5" "2688.9" "" "" "" "" "" "" "" "" "" "" "4199.6" "4046.8" "4346.8" "3704.8" "4204.1" "4569.4" "4214.1" "4215.0" "4426.6" "2688.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "130.011" "35" "30" "45" "16" "759" "87.6" "8.13" "154.00" "30" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "1.028" "0.955" "0.986" "0.973" "0.981" "0.973" "0.952" "0.975" "2.069" "1396.5" "1436.0" "1334.1" "1376.6" "1359.3" "1369.4" "1358.9" "1329.3" "1361.4" "2888.7" "" "" "" "" "" "" "" "" "" "" "1238.4" "1189.5" "1164.0" "1029.5" "1133.4" "1257.9" "1148.4" "1098.8" "1248.6" "2888.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "129.942" "24" "26" "35" "26" "1292" "141.2" "5.12" "129.69" "26" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.983" "0.979" "1.012" "0.966" "0.926" "1.064" "0.958" "1.007" "2.122" "3328.8" "3271.4" "3258.1" "3370.0" "3216.6" "3083.4" "3541.7" "3189.8" "3350.9" "7062.8" "" "" "" "" "" "" "" "" "" "" "2951.9" "2709.8" "2842.8" "2520.3" "2682.2" "2832.4" "2993.3" "2636.6" "3073.2" "7062.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "High" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.000" "False" "129.803" "46" "23" "31" "23" "518" "58.4" "9.11" "119.78" "23" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.028" "1.032" "0.996" "1.020" "1.051" "1.010" "1.045" "1.000" "0.198" "3558.1" "3657.4" "3672.8" "3545.4" "3630.6" "3738.9" "3594.2" "3717.8" "3558.4" "704.6" "" "" "" "" "" "" "" "" "" "" "3155.3" "3029.6" "3204.7" "2651.5" "3027.4" "3434.6" "3037.7" "3073.0" "3263.5" "704.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "129.682" "43" "16" "27" "16" "399" "44.2" "4.73" "112.24" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Removal of the Flap Intermediate from the C-strand" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "16" "0" "1.034" "1.070" "0.982" "0.962" "1.026" "0.770" "0.737" "0.804" "1.165" "3961.3" "4096.6" "4240.3" "3888.7" "3812.0" "4062.4" "3048.3" "2918.5" "3185.0" "4614.8" "" "" "" "" "" "" "" "" "" "" "3512.8" "3393.4" "3699.8" "2908.3" "3178.7" "3731.8" "2576.3" "2412.4" "2921.1" "4614.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "129.554" "44" "10" "36" "10" "342" "36.7" "5.17" "158.69" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "RMTs methylate histone arginines; snRNP Assembly" "" "2" "0" "1.012" "0.998" "0.957" "1.062" "1.009" "1.024" "1.026" "0.886" "0.706" "2151.2" "2177.1" "2147.5" "2058.2" "2285.0" "2171.5" "2203.7" "2207.4" "1906.3" "1519.3" "" "" "" "" "" "" "" "" "" "" "1907.7" "1803.4" "1873.8" "1539.3" "1905.4" "1994.7" "1862.5" "1824.5" "1748.3" "1519.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "129.341" "42" "15" "38" "15" "306" "33.7" "5.08" "133.52" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "6" "0" "0.995" "0.939" "0.979" "0.901" "0.901" "0.902" "0.239" "0.898" "15.965" "1861.6" "1851.7" "1748.4" "1822.1" "1677.6" "1677.5" "1679.3" "444.5" "1672.5" "29720.4" "" "" "" "" "" "" "" "" "" "" "1650.8" "1533.8" "1525.5" "1362.7" "1398.9" "1540.9" "1419.3" "367.4" "1533.9" "29720.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "129.322" "32" "15" "34" "8" "616" "64.4" "7.25" "131.53" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.024" "1.012" "1.105" "1.043" "0.910" "1.084" "1.065" "1.028" "1.003" "751.7" "769.6" "760.4" "830.3" "784.1" "684.2" "814.8" "800.5" "772.5" "754.2" "" "" "" "" "" "" "" "" "" "" "666.6" "637.5" "663.5" "620.9" "653.8" "628.5" "688.7" "661.7" "708.5" "754.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "129.259" "60" "12" "51" "12" "218" "24.5" "5.94" "212.79" "12" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "RAB geranylgeranylation; TBC/RABGAPs" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "5" "0" "0.995" "1.033" "1.065" "1.035" "1.025" "1.022" "1.053" "0.930" "0.512" "6888.1" "6855.5" "7113.7" "7338.1" "7126.1" "7060.3" "7037.7" "7253.2" "6405.0" "3524.1" "" "" "" "" "" "" "" "" "" "" "6108.3" "5678.7" "6207.0" "5487.9" "5942.2" "6485.6" "5947.9" "5995.3" "5874.2" "3524.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.000" "False" "129.211" "21" "21" "41" "21" "1192" "129.9" "4.50" "151.35" "21" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Axonal growth inhibition (RHOA activation)" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "7" "0" "1.015" "1.009" "1.011" "1.021" "1.019" "1.028" "1.034" "1.010" "0.726" "4597.0" "4666.1" "4637.4" "4647.2" "4691.9" "4685.4" "4723.7" "4753.1" "4642.9" "3337.9" "" "" "" "" "" "" "" "" "" "" "4076.5" "3865.2" "4046.4" "3475.5" "3912.4" "4304.1" "3992.3" "3928.8" "4258.2" "3337.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "129.084" "40" "15" "23" "15" "468" "54.4" "5.68" "108.96" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "Detoxification of Reactive Oxygen Species" "" "1" "0" "0.944" "0.946" "0.926" "0.864" "0.768" "0.936" "0.893" "0.894" "0.880" "2359.8" "2228.2" "2232.2" "2185.3" "2039.6" "1813.2" "2208.5" "2107.6" "2110.0" "2076.7" "" "" "" "" "" "" "" "" "" "" "2092.6" "1845.8" "1947.7" "1634.3" "1700.7" "1665.7" "1866.6" "1742.0" "1935.2" "2076.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "129.032" "57" "15" "120" "10" "246" "28.2" "4.84" "368.91" "15" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "1.132" "1.052" "1.016" "1.065" "1.095" "0.966" "1.003" "1.041" "0.676" "3775.9" "4274.7" "3971.0" "3836.6" "4022.0" "4135.0" "3648.4" "3785.8" "3930.7" "2553.9" "" "" "" "" "" "" "" "" "" "" "3348.4" "3541.0" "3464.9" "2869.2" "3353.8" "3798.5" "3083.4" "3129.2" "3605.0" "2553.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "128.954" "46" "18" "29" "17" "523" "56.5" "6.42" "112.41" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "MHC class II antigen presentation; RHO GTPases Activate Formins; HCMV Early Events; Separation of Sister Chromatids; Neutrophil degranulation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "16" "1" "0.896" "1.016" "1.000" "0.952" "0.946" "1.212" "1.193" "1.192" "1.335" "3643.6" "3263.8" "3703.0" "3644.7" "3468.7" "3448.5" "4416.7" "4347.3" "4342.1" "4862.4" "" "" "" "" "" "" "" "" "" "" "3231.0" "2703.6" "3231.1" "2725.7" "2892.4" "3167.9" "3732.8" "3593.4" "3982.3" "4862.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "128.330" "42" "12" "52" "3" "327" "37.2" "6.19" "178.40" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Circadian Clock; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "19" "0" "0.976" "1.006" "1.043" "1.004" "0.983" "1.025" "1.003" "0.938" "0.741" "706.6" "689.5" "710.6" "736.8" "709.6" "694.9" "724.2" "708.4" "662.7" "523.4" "" "" "" "" "" "" "" "" "" "" "626.6" "571.2" "620.1" "551.0" "591.7" "638.3" "612.1" "585.6" "607.8" "523.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "128.208" "54" "14" "41" "14" "289" "33.7" "6.74" "170.05" "14" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "mRNA Splicing - Major Pathway" "" "1" "0" "0.948" "0.965" "0.966" "0.953" "1.004" "0.979" "0.988" "0.997" "0.472" "4341.5" "4117.4" "4190.5" "4194.1" "4138.2" "4359.2" "4250.3" "4287.8" "4327.9" "2047.6" "" "" "" "" "" "" "" "" "" "" "3850.0" "3410.6" "3656.4" "3136.6" "3450.7" "4004.5" "3592.1" "3544.2" "3969.3" "2047.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "127.987" "67" "15" "41" "15" "211" "24.2" "5.74" "151.05" "15" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "1.026" "1.004" "1.007" "1.007" "1.004" "1.043" "1.042" "1.064" "0.565" "3469.5" "3559.9" "3484.7" "3494.7" "3493.0" "3484.9" "3617.6" "3615.3" "3690.7" "1959.9" "" "" "" "" "" "" "" "" "" "" "3076.7" "2948.9" "3040.6" "2613.6" "2912.7" "3201.2" "3057.4" "2988.3" "3384.9" "1959.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "127.671" "31" "15" "24" "15" "543" "60.9" "5.91" "107.23" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "13" "0" "0.994" "1.076" "1.094" "1.078" "1.087" "1.662" "1.651" "1.654" "1.195" "2512.3" "2496.7" "2703.2" "2748.1" "2707.1" "2730.6" "4175.9" "4147.6" "4155.4" "3002.5" "" "" "" "" "" "" "" "" "" "" "2227.9" "2068.2" "2358.7" "2055.2" "2257.4" "2508.4" "3529.3" "3428.3" "3811.1" "3002.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.000" "False" "127.597" "23" "15" "27" "13" "767" "86.4" "6.89" "117.23" "15" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "" "Sterol regulatory element-binding proteins (SREBP) signaling" "1" "2" "1.035" "0.997" "1.085" "1.096" "1.045" "1.088" "1.044" "0.989" "1.623" "2481.1" "2567.8" "2473.0" "2690.9" "2718.4" "2592.5" "2698.5" "2590.9" "2453.5" "4025.6" "" "" "" "" "" "" "" "" "" "" "2200.2" "2127.0" "2157.8" "2012.4" "2266.8" "2381.5" "2280.6" "2141.6" "2250.2" "4025.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "127.592" "68" "11" "47" "6" "180" "20.5" "7.14" "189.33" "11" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium" "VEGFA-VEGFR2 signaling" "4" "0" "0.976" "0.991" "1.051" "1.056" "0.984" "1.093" "1.009" "0.869" "0.853" "2866.7" "2798.6" "2842.2" "3013.2" "3026.3" "2821.2" "3131.9" "2892.4" "2490.8" "2446.2" "" "" "" "" "" "" "" "" "" "" "2542.1" "2318.2" "2480.0" "2253.4" "2523.5" "2591.6" "2646.9" "2390.7" "2284.4" "2446.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "127.507" "41" "10" "22" "10" "327" "36.1" "5.73" "101.89" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "6" "0" "0.978" "0.968" "1.039" "1.017" "1.021" "1.036" "1.014" "0.906" "0.542" "3340.1" "3266.0" "3232.8" "3469.8" "3397.6" "3410.4" "3459.6" "3386.1" "3026.1" "1811.6" "" "" "" "" "" "" "" "" "" "" "2962.0" "2705.4" "2820.7" "2595.0" "2833.2" "3132.8" "2923.9" "2798.8" "2775.3" "1811.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "127.495" "52" "14" "47" "3" "330" "37.5" "6.33" "166.82" "14" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "15" "1" "0.956" "0.969" "1.018" "0.971" "0.934" "0.964" "0.896" "0.839" "0.686" "883.4" "844.3" "855.7" "899.0" "858.0" "825.0" "851.8" "791.7" "741.0" "605.6" "" "" "" "" "" "" "" "" "" "" "783.4" "699.4" "746.6" "672.3" "715.5" "757.9" "719.9" "654.4" "679.6" "605.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "127.360" "37" "15" "32" "14" "454" "51.4" "8.19" "121.01" "15" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan catabolism" "Tryptophan metabolism" "2" "1" "1.011" "1.003" "1.042" "1.045" "1.085" "1.009" "1.082" "0.944" "0.503" "4902.6" "4955.6" "4916.4" "5106.9" "5120.8" "5320.7" "4945.1" "5302.9" "4628.2" "2467.3" "" "" "" "" "" "" "" "" "" "" "4347.5" "4105.0" "4289.8" "3819.3" "4270.0" "4887.6" "4179.4" "4383.2" "4244.7" "2467.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "127.279" "19" "16" "22" "16" "1303" "140.2" "6.27" "101.93" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "0.971" "1.030" "0.980" "0.963" "0.909" "0.898" "0.890" "0.937" "0.710" "3333.5" "3236.8" "3432.6" "3266.2" "3211.5" "3031.4" "2994.5" "2966.2" "3123.7" "2368.2" "" "" "" "" "" "" "" "" "" "" "2956.1" "2681.2" "2995.1" "2442.7" "2678.0" "2784.7" "2530.8" "2451.8" "2864.9" "2368.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "127.237" "47" "14" "56" "12" "334" "37.9" "7.39" "205.04" "14" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "" "2" "0" "0.990" "1.009" "1.001" "0.999" "1.024" "1.030" "1.048" "1.000" "0.491" "4914.7" "4867.8" "4957.4" "4917.2" "4909.3" "5032.5" "5060.4" "5152.4" "4916.6" "2412.6" "" "" "" "" "" "" "" "" "" "" "4358.2" "4032.2" "4325.5" "3677.4" "4093.7" "4622.9" "4276.8" "4258.8" "4509.2" "2412.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "126.986" "40" "15" "30" "14" "463" "50.5" "9.52" "132.34" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "1" "0.950" "0.986" "1.016" "0.982" "0.985" "0.944" "0.992" "1.023" "0.927" "3482.7" "3308.6" "3434.3" "3538.0" "3421.1" "3431.6" "3288.5" "3455.4" "3562.7" "3227.5" "" "" "" "" "" "" "" "" "" "" "3088.4" "2740.6" "2996.6" "2645.9" "2852.7" "3152.3" "2779.3" "2856.1" "3267.5" "3227.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "126.964" "53" "12" "40" "10" "297" "34.1" "8.40" "167.11" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "50" "1" "0.980" "1.000" "1.017" "1.019" "1.042" "1.054" "1.038" "1.052" "2.358" "3865.8" "3788.3" "3864.6" "3931.8" "3939.7" "4027.2" "4073.1" "4013.5" "4067.2" "9115.4" "" "" "" "" "" "" "" "" "" "" "3428.1" "3138.1" "3372.0" "2940.5" "3285.2" "3699.4" "3442.4" "3317.5" "3730.2" "9115.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "126.790" "37" "20" "33" "20" "645" "73.5" "8.02" "129.41" "20" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.036" "1.040" "1.080" "1.141" "1.112" "1.115" "1.100" "0.970" "0.453" "3277.6" "3396.0" "3408.2" "3541.3" "3739.0" "3644.0" "3654.0" "3605.4" "3180.8" "1484.4" "" "" "" "" "" "" "" "" "" "" "2906.5" "2813.1" "2973.8" "2648.4" "3117.8" "3347.4" "3088.2" "2980.1" "2917.3" "1484.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "126.788" "70" "11" "83" "11" "135" "15.2" "7.01" "382.47" "11" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "PPAR signaling pathway; Fatty acid transporters" "5" "0" "0.992" "1.001" "0.991" "0.983" "0.962" "1.003" "1.022" "0.989" "0.486" "10768.9" "10679.7" "10783.7" "10675.3" "10589.4" "10361.7" "10800.8" "11009.6" "10650.5" "5238.2" "" "" "" "" "" "" "" "" "" "" "9549.6" "8846.6" "9409.3" "7983.7" "8830.1" "9518.4" "9128.4" "9100.2" "9768.0" "5238.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "126.604" "56" "11" "48" "11" "282" "31.4" "7.02" "210.88" "11" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Glutathione conjugation" "Phase I biotransformations, non-P450" "2" "0" "0.991" "1.028" "1.015" "1.034" "1.038" "1.052" "1.070" "1.003" "0.498" "5503.2" "5452.0" "5659.8" "5587.2" "5691.5" "5712.1" "5789.6" "5887.4" "5518.0" "2743.3" "" "" "" "" "" "" "" "" "" "" "4880.1" "4516.2" "4938.4" "4178.5" "4745.9" "5247.2" "4893.1" "4866.3" "5060.8" "2743.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.000" "False" "126.535" "36" "20" "44" "20" "666" "73.1" "5.59" "153.80" "20" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "TYROBP causal network in microglia" "11" "0" "1.001" "1.024" "0.976" "1.023" "1.032" "0.938" "0.968" "0.951" "0.815" "4970.1" "4972.9" "5089.2" "4851.6" "5084.5" "5126.7" "4660.4" "4809.9" "4724.7" "4049.3" "" "" "" "" "" "" "" "" "" "" "4407.3" "4119.3" "4440.6" "3628.4" "4239.8" "4709.5" "3938.8" "3975.7" "4333.2" "4049.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6803776007100694472" "False" "High" "IsMasterProtein" "P51580" "Thiopurine S-methyltransferase OS=Homo sapiens OX=9606 GN=TPMT PE=1 SV=1" "0.000" "False" "126.275" "55" "12" "34" "12" "245" "28.2" "6.23" "139.39" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf05724" "7172" "ENSG00000137364" "TPMT" "hsa:7172; O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; P51580; Q5VUK6; Q9UBE6; Q9UBT8; Q9UE62" "Azathioprine ADME; Methylation; Defective TPMT causes TPMT deficiency" "Metapathway biotransformation Phase I and II; Methylation pathways" "5" "0" "1.048" "1.051" "1.094" "1.078" "1.069" "1.092" "1.120" "1.009" "0.600" "2874.8" "3012.9" "3021.2" "3143.9" "3097.6" "3071.9" "3139.9" "3221.0" "2900.2" "1723.6" "" "" "" "" "" "" "" "" "" "" "2549.3" "2495.8" "2636.1" "2351.2" "2583.0" "2821.9" "2653.8" "2662.4" "2659.8" "1723.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559425132157333598" "False" "High" "IsMasterProtein" "P16152" "Carbonyl reductase [NADPH] 1 OS=Homo sapiens OX=9606 GN=CBR1 PE=1 SV=3" "0.000" "False" "126.182" "58" "12" "27" "12" "277" "30.4" "8.32" "111.84" "12" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00106" "873" "ENSG00000159228" "CBR1" "B2RBZ7; B4DFK7; hsa:873; P16152; Q3LHW8" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Nuclear receptors meta-pathway; NRF2 pathway; Omega-6-fatty acids in senescence; Prostaglandin synthesis and regulation" "5" "0" "1.106" "1.087" "1.157" "1.149" "1.138" "1.149" "1.146" "1.060" "0.754" "2206.3" "2441.0" "2398.9" "2552.5" "2534.3" "2509.9" "2534.8" "2529.4" "2338.9" "1662.6" "" "" "" "" "" "" "" "" "" "" "1956.5" "2022.0" "2093.1" "1908.9" "2113.2" "2305.6" "2142.3" "2090.7" "2145.1" "1662.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6687870354662644574" "False" "High" "IsMasterProtein" "Q8N3D4" "EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2" "0.000" "False" "126.160" "15" "18" "24" "18" "1523" "161.8" "4.83" "98.15" "18" "" "other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "254102" "ENSG00000173442" "EHBP1L1" "hsa:254102; Q8N3D4; Q8TB89; Q9H7M7" "" "" "0" "0" "1.048" "0.980" "1.057" "1.000" "0.976" "1.070" "0.947" "0.992" "1.917" "1858.4" "1946.8" "1821.7" "1965.2" "1858.1" "1812.9" "1987.9" "1760.2" "1844.1" "3562.7" "" "" "" "" "" "" "" "" "" "" "1648.0" "1612.6" "1589.5" "1469.7" "1549.4" "1665.4" "1680.1" "1454.9" "1691.3" "3562.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "126.084" "31" "14" "54" "14" "466" "51.7" "8.32" "174.27" "14" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.951" "0.980" "0.980" "0.973" "0.952" "1.040" "1.009" "0.971" "0.703" "5562.7" "5288.0" "5450.5" "5451.2" "5412.2" "5293.2" "5784.4" "5613.8" "5399.1" "3912.9" "" "" "" "" "" "" "" "" "" "" "4932.9" "4380.3" "4755.9" "4076.8" "4513.1" "4862.4" "4888.7" "4640.2" "4951.7" "3912.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2383613337026514959" "False" "High" "IsMasterProtein" "Q93052" "Lipoma-preferred partner OS=Homo sapiens OX=9606 GN=LPP PE=1 SV=1" "0.000" "False" "126.059" "37" "14" "27" "14" "612" "65.7" "7.37" "115.70" "14" "cell adhesion" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "4026" "ENSG00000145012" "LPP" "A1L4L6; D3DNV6; hsa:4026; Q8NFX5; Q93052" "" "MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement" "1" "0" "0.903" "0.903" "0.854" "0.860" "0.877" "0.731" "0.869" "0.886" "0.432" "2849.6" "2572.0" "2574.2" "2434.1" "2450.9" "2498.8" "2084.3" "2476.0" "2524.7" "1230.7" "" "" "" "" "" "" "" "" "" "" "2526.9" "2130.5" "2246.1" "1820.4" "2043.7" "2295.4" "1761.6" "2046.6" "2315.5" "1230.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "126.045" "49" "11" "33" "11" "293" "32.8" "7.50" "144.21" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.040" "0.995" "1.047" "1.059" "1.049" "1.029" "1.079" "0.937" "0.375" "3362.6" "3498.6" "3345.6" "3522.3" "3559.7" "3526.7" "3459.9" "3629.0" "3149.1" "1260.9" "" "" "" "" "" "" "" "" "" "" "2981.8" "2898.0" "2919.2" "2634.2" "2968.3" "3239.7" "2924.2" "2999.6" "2888.2" "1260.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "125.809" "31" "19" "32" "19" "736" "82.8" "7.31" "121.84" "19" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "0.947" "0.949" "0.929" "0.906" "0.898" "0.830" "0.889" "0.948" "0.871" "3269.8" "3096.9" "3104.2" "3036.9" "2962.1" "2935.3" "2712.5" "2908.5" "3099.5" "2847.7" "" "" "" "" "" "" "" "" "" "" "2899.6" "2565.4" "2708.6" "2271.2" "2470.0" "2696.4" "2292.5" "2404.0" "2842.7" "2847.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "125.688" "55" "8" "52" "8" "121" "13.6" "4.82" "209.71" "8" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "0.976" "0.975" "1.057" "0.989" "0.985" "0.980" "0.971" "0.966" "0.530" "3414.4" "3333.7" "3329.2" "3607.4" "3375.3" "3361.5" "3344.7" "3314.0" "3298.1" "1809.3" "" "" "" "" "" "" "" "" "" "" "3027.8" "2761.5" "2904.9" "2697.9" "2814.6" "3088.0" "2826.8" "2739.2" "3024.8" "1809.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "125.649" "59" "17" "40" "17" "297" "33.6" "6.96" "143.03" "17" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "1.000" "0.992" "1.023" "1.035" "1.064" "1.015" "1.031" "0.976" "0.588" "3605.1" "3604.9" "3577.0" "3689.0" "3732.8" "3837.4" "3658.7" "3715.3" "3517.0" "2119.6" "" "" "" "" "" "" "" "" "" "" "3197.0" "2986.1" "3121.1" "2758.9" "3112.6" "3525.1" "3092.2" "3070.9" "3225.6" "2119.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "High" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.000" "False" "125.634" "51" "11" "32" "11" "282" "31.5" "5.52" "125.88" "11" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "0.997" "0.995" "1.047" "1.034" "1.042" "0.908" "0.941" "0.911" "0.196" "2803.9" "2795.9" "2790.9" "2936.9" "2900.1" "2922.1" "2546.5" "2639.5" "2554.3" "549.1" "" "" "" "" "" "" "" "" "" "" "2486.4" "2316.0" "2435.2" "2196.4" "2418.3" "2684.2" "2152.2" "2181.7" "2342.7" "549.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "125.627" "65" "10" "39" "7" "215" "23.6" "8.15" "144.50" "10" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "16" "0" "1.055" "1.056" "1.104" "1.050" "1.075" "1.112" "1.012" "0.990" "0.667" "1519.9" "1603.6" "1605.7" "1677.2" "1596.3" "1633.5" "1690.5" "1538.7" "1504.7" "1013.7" "" "" "" "" "" "" "" "" "" "" "1347.8" "1328.3" "1401.0" "1254.4" "1331.1" "1500.6" "1428.8" "1271.8" "1380.0" "1013.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "High" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.000" "False" "125.522" "42" "14" "32" "14" "423" "47.7" "5.90" "136.89" "14" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.999" "0.972" "1.012" "0.991" "0.994" "1.015" "1.038" "1.000" "0.567" "3906.9" "3903.5" "3796.8" "3955.1" "3872.7" "3881.9" "3964.1" "4055.3" "3906.7" "2216.9" "" "" "" "" "" "" "" "" "" "" "3464.6" "3233.5" "3312.9" "2957.9" "3229.3" "3566.0" "3350.3" "3352.0" "3583.0" "2216.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908270249902800016" "False" "High" "IsMasterProtein" "P35573" "Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3" "0.000" "False" "125.487" "21" "32" "38" "32" "1532" "174.7" "6.76" "129.82" "32" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06202, Pf14699, Pf14701, Pf14702" "178" "ENSG00000162688" "AGL" "A6NCX7; A6NEK2; D3DT51; hsa:178; P35573; P78354; P78544; Q59H92; Q6AZ90; Q9UF08" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "Glycogen synthesis and degradation" "3" "0" "0.945" "0.927" "0.975" "0.963" "0.881" "1.090" "0.935" "1.005" "2.847" "2882.7" "2725.2" "2672.7" "2809.6" "2776.6" "2538.7" "3142.9" "2694.3" "2896.8" "8207.4" "" "" "" "" "" "" "" "" "" "" "2556.3" "2257.4" "2332.0" "2101.2" "2315.3" "2332.1" "2656.2" "2227.0" "2656.7" "8207.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6388610480367959150" "False" "High" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1" "0.000" "False" "125.484" "29" "9" "23" "9" "510" "55.0" "8.51" "117.70" "9" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "2q13 copy number variation syndrome" "6" "0" "0.948" "1.031" "1.014" "1.018" "0.999" "0.981" "1.016" "1.013" "0.423" "2160.6" "2047.8" "2228.5" "2190.0" "2200.3" "2158.5" "2119.2" "2195.6" "2189.5" "914.8" "" "" "" "" "" "" "" "" "" "" "1916.0" "1696.3" "1944.5" "1637.9" "1834.7" "1982.8" "1791.0" "1814.8" "2008.1" "914.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "125.401" "61" "15" "32" "15" "258" "29.0" "5.81" "117.71" "15" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Intra-Golgi traffic; Neutrophil degranulation" "Ciliary landscape; 22q11.2 copy number variation syndrome" "4" "0" "1.029" "1.006" "1.040" "1.019" "0.989" "1.000" "1.052" "1.080" "0.772" "2452.2" "2523.9" "2466.8" "2551.2" "2498.1" "2426.2" "2453.1" "2579.1" "2649.5" "1894.1" "" "" "" "" "" "" "" "" "" "" "2174.5" "2090.6" "2152.4" "1908.0" "2083.1" "2228.7" "2073.2" "2131.8" "2429.9" "1894.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "125.150" "50" "10" "34" "10" "271" "31.3" "4.94" "162.23" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "Ub-specific processing proteases; Ovarian tumor domain proteases" "" "2" "0" "1.082" "1.033" "1.052" "1.081" "1.206" "1.088" "1.065" "1.079" "0.819" "2329.1" "2520.9" "2406.7" "2449.6" "2517.4" "2809.0" "2533.7" "2480.2" "2513.5" "1908.7" "" "" "" "" "" "" "" "" "" "" "2065.4" "2088.2" "2099.9" "1832.0" "2099.2" "2580.4" "2141.4" "2050.0" "2305.3" "1908.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8005629595719536467" "False" "High" "IsMasterProtein" "Q12840" "Kinesin heavy chain isoform 5A OS=Homo sapiens OX=9606 GN=KIF5A PE=1 SV=2" "0.000" "False" "125.108" "17" "19" "55" "8" "1032" "117.3" "5.90" "175.15" "19" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3798" "ENSG00000155980" "KIF5A" "A6H8M5; hsa:3798; Q12840; Q4LE26" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Insulin processing; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "7" "0" "0.934" "0.917" "0.948" "0.869" "0.790" "0.839" "0.867" "0.924" "1.430" "737.4" "688.9" "676.0" "698.7" "640.5" "582.9" "618.6" "639.6" "681.0" "1054.1" "" "" "" "" "" "" "" "" "" "" "653.9" "570.6" "589.9" "522.6" "534.1" "535.4" "522.8" "528.7" "624.6" "1054.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "125.069" "52" "14" "48" "4" "323" "37.0" "6.54" "170.20" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "17" "12" "1.040" "1.040" "1.017" "1.064" "1.102" "1.018" "0.990" "0.944" "0.752" "3338.8" "3471.6" "3472.4" "3394.6" "3553.8" "3679.3" "3399.9" "3304.3" "3152.4" "2509.5" "" "" "" "" "" "" "" "" "" "" "2960.8" "2875.7" "3029.8" "2538.7" "2963.4" "3379.8" "2873.4" "2731.2" "2891.1" "2509.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "125.066" "65" "17" "31" "17" "296" "31.7" "6.55" "132.65" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "1.013" "0.977" "1.101" "1.050" "0.979" "1.061" "1.026" "0.868" "0.501" "2167.0" "2194.4" "2117.8" "2384.9" "2274.3" "2121.2" "2299.0" "2224.2" "1880.7" "1084.8" "" "" "" "" "" "" "" "" "" "" "1921.7" "1817.8" "1847.9" "1783.6" "1896.5" "1948.6" "1943.1" "1838.5" "1724.8" "1084.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "125.031" "28" "22" "33" "22" "847" "94.6" "6.25" "122.59" "22" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "1.026" "0.977" "0.976" "0.927" "1.005" "0.922" "0.619" "0.958" "7.661" "1908.6" "1958.6" "1864.2" "1863.4" "1769.5" "1918.5" "1759.8" "1181.6" "1828.4" "14622.2" "" "" "" "" "" "" "" "" "" "" "1692.5" "1622.4" "1626.6" "1393.6" "1475.5" "1762.3" "1487.3" "976.6" "1676.9" "14622.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "124.691" "48" "14" "39" "12" "375" "42.8" "4.69" "152.33" "14" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "2" "0.991" "1.023" "1.028" "1.003" "0.976" "0.957" "1.024" "0.987" "0.777" "5911.4" "5856.5" "6045.7" "6074.2" "5926.5" "5771.0" "5654.6" "6052.6" "5837.0" "4590.4" "" "" "" "" "" "" "" "" "" "" "5242.1" "4851.2" "5275.2" "4542.7" "4941.9" "5301.3" "4779.1" "5002.9" "5353.3" "4590.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "124.455" "36" "15" "64" "12" "378" "39.6" "9.01" "203.08" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "0" "0.962" "0.991" "0.886" "0.884" "0.978" "0.893" "0.801" "0.986" "3.028" "3504.7" "3371.8" "3471.7" "3106.7" "3098.2" "3428.8" "3128.1" "2805.7" "3456.1" "10613.2" "" "" "" "" "" "" "" "" "" "" "3107.9" "2793.0" "3029.3" "2323.4" "2583.5" "3149.7" "2643.7" "2319.1" "3169.7" "10613.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "124.122" "35" "17" "27" "16" "623" "62.0" "5.24" "105.99" "17" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "Formation of the cornified envelope" "" "2" "0" "0.683" "1.296" "4.360" "1.251" "1.882" "1.135" "0.548" "1.080" "1.638" "1446.9" "988.1" "1874.7" "6308.6" "1810.6" "2723.2" "1642.9" "792.9" "1562.6" "2369.7" "" "" "" "" "" "" "" "" "" "" "1283.1" "818.5" "1635.8" "4718.0" "1509.8" "2501.6" "1388.5" "655.4" "1433.1" "2369.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5079617610391410578" "False" "High" "IsMasterProtein" "Q3ZCM7" "Tubulin beta-8 chain OS=Homo sapiens OX=9606 GN=TUBB8 PE=1 SV=2" "0.000" "False" "124.118" "21" "10" "209" "1" "444" "49.7" "4.89" "529.26" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "347688" "ENSG00000261456" "TUBB8" "hsa:347688; Q3ZCM7; Q5SQX9; Q8WZ78" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Recruitment of NuMA to mitotic centrosomes; Cilium Assembly; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "31" "0" "0.969" "0.892" "1.053" "0.811" "0.914" "1.041" "0.842" "0.864" "0.655" "107.4" "104.0" "95.8" "113.1" "87.2" "98.2" "111.9" "90.4" "92.8" "70.3" "" "" "" "" "" "" "" "" "" "" "95.3" "86.2" "83.6" "84.6" "72.7" "90.2" "94.6" "74.7" "85.1" "70.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "124.044" "25" "16" "21" "16" "826" "92.4" "5.96" "98.00" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "HATs acetylate histones" "" "1" "0" "1.067" "1.022" "1.125" "1.117" "1.046" "1.049" "1.069" "0.897" "0.942" "1963.5" "2094.4" "2006.2" "2208.8" "2193.4" "2054.0" "2059.8" "2099.9" "1761.0" "1849.2" "" "" "" "" "" "" "" "" "" "" "1741.2" "1734.9" "1750.5" "1651.9" "1829.0" "1886.9" "1740.9" "1735.7" "1615.0" "1849.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.000" "False" "124.001" "22" "26" "34" "26" "1272" "141.3" "5.41" "115.49" "26" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "14" "0" "0.986" "0.931" "1.007" "0.938" "0.960" "0.968" "0.611" "0.955" "7.799" "1904.5" "1878.8" "1773.2" "1917.8" "1785.6" "1828.4" "1843.5" "1164.3" "1817.9" "14854.0" "" "" "" "" "" "" "" "" "" "" "1688.9" "1556.3" "1547.2" "1434.3" "1489.0" "1679.6" "1558.0" "962.4" "1667.3" "14854.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.000" "False" "123.869" "34" "14" "20" "14" "552" "63.2" "5.94" "91.06" "14" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.982" "0.943" "1.047" "1.026" "1.067" "1.025" "1.049" "0.978" "0.580" "2279.3" "2238.0" "2149.6" "2385.5" "2338.4" "2432.6" "2337.2" "2390.3" "2229.2" "1322.4" "" "" "" "" "" "" "" "" "" "" "2021.2" "1853.9" "1875.7" "1784.1" "1949.9" "2234.6" "1975.3" "1975.8" "2044.5" "1322.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "123.658" "54" "17" "37" "13" "350" "40.3" "6.96" "130.17" "17" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "" "3" "5" "1.052" "1.051" "1.041" "1.013" "1.044" "1.018" "1.048" "0.976" "0.572" "4056.2" "4267.8" "4264.4" "4224.0" "4109.8" "4234.2" "4130.6" "4252.7" "3960.0" "2318.8" "" "" "" "" "" "" "" "" "" "" "3597.0" "3535.2" "3720.9" "3159.0" "3427.0" "3889.6" "3491.0" "3515.1" "3631.9" "2318.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "123.377" "41" "18" "26" "18" "559" "59.8" "5.29" "104.84" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.022" "1.008" "0.945" "1.011" "1.048" "0.913" "0.812" "0.923" "3.041" "2404.3" "2457.5" "2423.7" "2273.0" "2430.5" "2519.3" "2194.6" "1952.8" "2218.2" "7311.8" "" "" "" "" "" "" "" "" "" "" "2132.1" "2035.7" "2114.8" "1699.9" "2026.7" "2314.3" "1854.8" "1614.1" "2034.4" "7311.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "123.256" "36" "19" "37" "8" "530" "58.9" "6.89" "136.57" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "12" "6" "0.988" "1.009" "1.045" "1.069" "1.030" "1.066" "1.081" "1.016" "0.681" "3777.3" "3733.5" "3811.6" "3947.0" "4038.8" "3891.6" "4027.4" "4082.0" "3839.1" "2571.7" "" "" "" "" "" "" "" "" "" "" "3349.6" "3092.7" "3325.8" "2951.9" "3367.8" "3574.9" "3403.8" "3374.0" "3521.0" "2571.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064398730154585057" "False" "High" "IsMasterProtein" "Q15061" "WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3" "0.000" "False" "122.955" "33" "20" "34" "20" "677" "74.8" "5.57" "122.10" "20" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04003" "23160" "ENSG00000163811" "WDR43" "hsa:23160; Q15061; Q15395; Q92577" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.983" "0.940" "0.995" "0.931" "0.941" "0.918" "0.970" "0.896" "0.223" "3591.9" "3530.6" "3376.1" "3573.1" "3343.2" "3380.0" "3299.0" "3482.5" "3216.9" "801.3" "" "" "" "" "" "" "" "" "" "" "3185.2" "2924.5" "2945.8" "2672.2" "2787.8" "3104.9" "2788.2" "2878.6" "2950.4" "801.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "122.826" "52" "15" "32" "14" "292" "33.5" "4.84" "124.36" "15" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "1" "0.993" "1.014" "0.909" "0.984" "1.050" "0.943" "1.014" "1.077" "0.702" "5225.0" "5186.9" "5296.2" "4750.2" "5143.5" "5487.5" "4927.9" "5296.3" "5627.0" "3666.3" "" "" "" "" "" "" "" "" "" "" "4633.4" "4296.6" "4621.2" "3552.5" "4289.0" "5040.9" "4164.8" "4377.8" "5160.7" "3666.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "122.790" "48" "13" "35" "13" "313" "34.8" "5.60" "127.44" "13" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "0.949" "0.953" "0.905" "0.894" "0.897" "1.045" "0.968" "1.027" "2.729" "3135.2" "2974.0" "2987.7" "2836.5" "2802.5" "2812.5" "3275.8" "3034.6" "3219.3" "8556.0" "" "" "" "" "" "" "" "" "" "" "2780.2" "2463.5" "2606.9" "2121.4" "2336.9" "2583.6" "2768.6" "2508.3" "2952.6" "8556.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "122.647" "56" "16" "37" "11" "360" "41.4" "6.98" "139.32" "16" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "NPAS4 regulates expression of target genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Recycling pathway of L1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; NCAM signaling for neurite out-growth; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "208" "4" "1.030" "1.006" "1.056" "1.064" "1.056" "1.050" "1.065" "0.983" "0.601" "3865.8" "3983.2" "3890.1" "4080.9" "4115.0" "4082.7" "4057.5" "4116.8" "3798.3" "2324.8" "" "" "" "" "" "" "" "" "" "" "3428.1" "3299.5" "3394.3" "3052.0" "3431.4" "3750.4" "3429.2" "3402.9" "3483.5" "2324.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "122.595" "36" "19" "33" "19" "507" "57.0" "6.37" "124.13" "19" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "1.013" "0.998" "1.055" "0.992" "0.937" "0.916" "0.978" "0.858" "0.585" "5403.5" "5476.0" "5394.4" "5699.4" "5357.7" "5061.1" "4947.8" "5286.0" "4636.3" "3158.7" "" "" "" "" "" "" "" "" "" "" "4791.7" "4536.0" "4706.9" "4262.4" "4467.6" "4649.2" "4181.7" "4369.2" "4252.1" "3158.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "122.434" "44" "17" "62" "17" "337" "37.5" "6.81" "215.92" "17" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "9" "0" "0.991" "1.009" "0.979" "0.971" "0.941" "0.971" "0.954" "0.938" "0.759" "9420.3" "9335.7" "9505.5" "9218.4" "9148.2" "8865.4" "9143.4" "8988.1" "8831.7" "7153.8" "" "" "" "" "" "" "" "" "" "" "8353.8" "7733.2" "8294.0" "6894.1" "7628.3" "8143.9" "7727.6" "7429.3" "8099.8" "7153.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "121.930" "48" "13" "29" "13" "344" "37.4" "6.24" "116.45" "13" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.175" "1.011" "1.158" "1.141" "1.129" "1.152" "1.064" "1.022" "0.536" "1701.6" "1999.8" "1720.6" "1970.9" "1941.3" "1921.4" "1960.7" "1810.4" "1738.5" "912.2" "" "" "" "" "" "" "" "" "" "" "1509.0" "1656.6" "1501.3" "1474.0" "1618.7" "1765.0" "1657.1" "1496.4" "1594.4" "912.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "121.748" "28" "22" "33" "21" "864" "97.0" "5.58" "120.95" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "Neurexins and neuroligins" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "4" "0" "1.010" "0.985" "0.951" "0.932" "0.965" "0.893" "0.970" "0.988" "0.943" "2853.7" "2882.3" "2810.7" "2715.1" "2660.3" "2754.4" "2548.2" "2768.8" "2818.0" "2690.5" "" "" "" "" "" "" "" "" "" "" "2530.6" "2387.5" "2452.5" "2030.5" "2218.3" "2530.3" "2153.7" "2288.6" "2584.5" "2690.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "121.740" "22" "26" "31" "26" "1309" "146.6" "6.13" "111.69" "26" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "" "Translation factors" "1" "0" "1.078" "1.018" "1.102" "1.030" "0.889" "1.049" "0.657" "1.019" "7.214" "1141.2" "1230.4" "1162.1" "1257.2" "1175.4" "1014.1" "1197.4" "749.8" "1162.8" "8232.0" "" "" "" "" "" "" "" "" "" "" "1012.0" "1019.2" "1014.0" "940.2" "980.1" "931.5" "1012.0" "619.8" "1066.4" "8232.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5381217781487520932" "False" "High" "IsMasterProtein" "Q99536" "Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2" "0.000" "False" "121.655" "45" "11" "30" "11" "393" "41.9" "6.29" "120.07" "11" "other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf08240, Pf13602" "10493" "ENSG00000108828" "VAT1" "A8K345; B0AZP7; B4DPX4; hsa:10493; Q13035; Q5BKZ7; Q96A39; Q99536; Q9BUT8" "Neutrophil degranulation" "" "1" "0" "1.043" "1.069" "1.071" "1.174" "1.091" "1.069" "1.076" "1.044" "0.634" "2034.0" "2122.3" "2174.1" "2178.2" "2388.6" "2219.0" "2174.5" "2189.2" "2123.0" "1288.7" "" "" "" "" "" "" "" "" "" "" "1803.7" "1758.0" "1897.0" "1629.0" "1991.7" "2038.4" "1837.8" "1809.5" "1947.1" "1288.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "121.577" "51" "11" "22" "9" "307" "35.1" "5.06" "107.83" "11" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "Processing of DNA double-strand break ends" "16p11.2 proximal deletion syndrome" "2" "0" "1.024" "1.020" "1.096" "1.067" "1.111" "1.040" "1.029" "0.944" "0.832" "1489.3" "1524.5" "1519.4" "1632.9" "1588.9" "1654.5" "1549.5" "1533.2" "1405.5" "1238.4" "" "" "" "" "" "" "" "" "" "" "1320.6" "1262.9" "1325.7" "1221.2" "1325.0" "1519.8" "1309.6" "1267.3" "1289.0" "1238.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "121.529" "28" "14" "23" "14" "580" "64.4" "6.42" "103.91" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "2" "0" "0.986" "0.989" "1.008" "0.966" "0.995" "0.947" "1.029" "0.950" "0.730" "1874.7" "1848.9" "1855.0" "1889.9" "1810.6" "1865.7" "1774.5" "1929.8" "1780.1" "1367.9" "" "" "" "" "" "" "" "" "" "" "1662.5" "1531.5" "1618.5" "1413.4" "1509.8" "1713.9" "1499.7" "1595.1" "1632.6" "1367.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "121.517" "71" "9" "36" "8" "151" "16.3" "5.67" "141.27" "9" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "8" "1" "0.943" "0.946" "0.978" "0.938" "0.999" "0.932" "0.947" "0.959" "0.514" "4816.5" "4541.5" "4557.7" "4710.1" "4515.8" "4812.5" "4490.4" "4563.3" "4618.4" "2474.0" "" "" "" "" "" "" "" "" "" "" "4271.2" "3761.9" "3976.8" "3522.5" "3765.6" "4420.8" "3795.1" "3771.9" "4235.7" "2474.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "121.472" "20" "18" "28" "18" "1132" "119.3" "5.60" "109.92" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "0.962" "0.976" "0.949" "0.916" "0.927" "0.926" "0.896" "0.897" "1.789" "2064.3" "1986.1" "2014.7" "1958.7" "1891.8" "1914.1" "1911.2" "1849.4" "1852.2" "3693.8" "" "" "" "" "" "" "" "" "" "" "1830.6" "1645.2" "1757.9" "1464.9" "1577.5" "1758.3" "1615.3" "1528.7" "1698.7" "3693.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "121.348" "59" "11" "36" "11" "258" "27.5" "6.05" "152.17" "11" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate pathway" "Pentose phosphate metabolism" "2" "0" "1.071" "1.061" "1.138" "1.137" "1.064" "1.080" "1.055" "0.971" "0.600" "3547.8" "3798.0" "3765.0" "4038.9" "4033.5" "3775.6" "3832.6" "3743.8" "3444.2" "2130.0" "" "" "" "" "" "" "" "" "" "" "3146.1" "3146.1" "3285.1" "3020.6" "3363.4" "3468.3" "3239.2" "3094.5" "3158.8" "2130.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7497019614434814723" "False" "High" "IsMasterProtein" "Q9NQH7" "Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1" "0.000" "False" "121.094" "31" "13" "34" "12" "507" "57.0" "6.83" "115.89" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00557, Pf05195" "63929" "ENSG00000196236" "XPNPEP3" "B2R9G1; B7Z790; B7Z7B2; hsa:63929; Q6I9V9; Q8NDA6; Q9BV27; Q9BVH0; Q9NQH7" "" "Ciliary landscape; Ciliopathies" "2" "0" "1.006" "1.051" "1.041" "1.071" "1.078" "1.056" "1.111" "1.021" "0.503" "3027.1" "3043.9" "3182.6" "3149.9" "3243.5" "3262.2" "3198.1" "3361.7" "3091.2" "1522.7" "" "" "" "" "" "" "" "" "" "" "2684.4" "2521.4" "2776.9" "2355.7" "2704.6" "2996.7" "2702.9" "2778.7" "2835.1" "1522.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479844659917987073" "False" "High" "IsMasterProtein" "Q9NQ48" "Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1" "0.000" "False" "121.043" "49" "14" "34" "14" "299" "34.6" "5.36" "144.64" "14" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15294" "54585" "ENSG00000163818" "LZTFL1" "B3KSI9; B4E0K7; hsa:54585; Q8TC61; Q9NQ48; Q9NQ56" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "5" "0" "0.987" "0.914" "0.930" "0.917" "0.907" "0.907" "0.923" "0.931" "0.713" "4561.8" "4504.1" "4169.1" "4242.4" "4184.9" "4139.2" "4138.1" "4212.6" "4245.1" "3253.5" "" "" "" "" "" "" "" "" "" "" "4045.3" "3731.0" "3637.7" "3172.7" "3489.6" "3802.3" "3497.3" "3482.0" "3893.3" "3253.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "120.806" "20" "15" "31" "11" "898" "102.3" "4.98" "124.85" "15" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "Postmitotic nuclear pore complex (NPC) reformation; Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" "22q11.2 copy number variation syndrome" "4" "2" "1.052" "1.016" "1.054" "1.019" "1.014" "1.050" "0.766" "0.987" "6.075" "1895.4" "1993.5" "1925.1" "1996.9" "1931.3" "1922.3" "1990.1" "1452.7" "1870.7" "11515.1" "" "" "" "" "" "" "" "" "" "" "1680.8" "1651.3" "1679.8" "1493.4" "1610.4" "1765.8" "1682.0" "1200.7" "1715.6" "11515.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "120.424" "25" "21" "24" "21" "919" "101.7" "5.62" "97.12" "21" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "14" "0" "1.061" "0.972" "1.072" "0.967" "0.924" "0.924" "0.521" "1.015" "8.574" "1536.4" "1629.4" "1494.1" "1647.6" "1485.1" "1419.3" "1419.8" "801.1" "1559.4" "13173.0" "" "" "" "" "" "" "" "" "" "" "1362.5" "1349.8" "1303.6" "1232.2" "1238.4" "1303.8" "1200.0" "662.1" "1430.2" "13173.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "120.353" "36" "20" "35" "18" "461" "51.0" "6.68" "124.65" "20" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "Prevention of phagosomal-lysosomal fusion" "16p11.2 proximal deletion syndrome" "2" "2" "0.959" "0.950" "0.958" "0.917" "0.877" "0.958" "0.299" "1.005" "14.502" "1297.2" "1243.5" "1232.2" "1242.7" "1189.7" "1137.4" "1243.3" "387.4" "1303.7" "18811.8" "" "" "" "" "" "" "" "" "" "" "1150.3" "1030.0" "1075.1" "929.3" "992.1" "1044.8" "1050.8" "320.2" "1195.7" "18811.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "120.113" "47" "15" "98" "8" "215" "24.9" "5.74" "336.89" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "20" "0" "0.955" "0.975" "1.024" "0.995" "0.949" "0.883" "1.011" "0.992" "0.556" "8131.2" "7763.8" "7930.9" "8329.2" "8092.3" "7719.6" "7179.8" "8221.8" "8067.4" "4518.8" "" "" "" "" "" "" "" "" "" "" "7210.6" "6431.2" "6920.1" "6229.1" "6747.9" "7091.3" "6068.1" "6795.9" "7398.9" "4518.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "120.093" "44" "15" "57" "15" "255" "28.4" "5.33" "196.28" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.047" "1.079" "0.960" "1.051" "1.031" "1.011" "1.023" "1.068" "0.512" "6901.9" "7227.4" "7446.6" "6623.5" "7253.4" "7115.8" "6978.1" "7061.6" "7368.2" "3536.0" "" "" "" "" "" "" "" "" "" "" "6120.5" "5986.8" "6497.6" "4953.5" "6048.3" "6536.7" "5897.6" "5836.9" "6757.6" "3536.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "120.027" "54" "13" "63" "13" "255" "27.8" "8.10" "220.83" "13" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "Respiratory electron transport; Protein methylation" "" "2" "0" "0.935" "0.928" "0.979" "0.940" "0.900" "0.953" "0.946" "0.897" "0.516" "5679.7" "5310.8" "5270.2" "5558.9" "5340.7" "5109.1" "5414.0" "5370.7" "5096.8" "2929.3" "" "" "" "" "" "" "" "" "" "" "5036.6" "4399.2" "4598.5" "4157.3" "4453.5" "4693.3" "4575.7" "4439.2" "4674.4" "2929.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "119.901" "29" "20" "26" "20" "841" "95.9" "5.11" "95.12" "20" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "1.014" "0.989" "0.990" "0.962" "0.987" "0.968" "0.907" "0.925" "1.457" "2379.0" "2411.7" "2353.5" "2354.9" "2288.2" "2348.9" "2303.3" "2158.6" "2200.6" "3465.7" "" "" "" "" "" "" "" "" "" "" "2109.7" "1997.8" "2053.5" "1761.2" "1908.0" "2157.7" "1946.6" "1784.2" "2018.3" "3465.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251900378438964283" "False" "High" "IsMasterProtein" "Q13188" "Serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=STK3 PE=1 SV=2" "0.000" "False" "119.573" "28" "13" "26" "5" "491" "56.3" "5.24" "101.00" "13" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6788" "ENSG00000104375" "STK3" "A8K722; B3KYA7; hsa:6788; Q13188; Q15445; Q15801; Q96FM6" "Signaling by Hippo" "MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "9" "0" "1.162" "1.060" "1.303" "1.286" "1.095" "1.260" "1.210" "1.021" "0.915" "243.0" "282.3" "257.7" "316.6" "312.6" "266.1" "306.3" "294.0" "248.2" "222.3" "" "" "" "" "" "" "" "" "" "" "215.5" "233.9" "224.9" "236.8" "260.7" "244.4" "258.8" "243.0" "227.6" "222.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "119.528" "28" "22" "50" "20" "671" "74.3" "7.49" "164.81" "22" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "0.993" "0.945" "0.966" "0.902" "0.885" "0.847" "0.876" "0.843" "0.493" "5327.9" "5292.7" "5033.0" "5145.0" "4804.3" "4716.2" "4510.6" "4667.0" "4494.0" "2626.9" "" "" "" "" "" "" "" "" "" "" "4724.7" "4384.2" "4391.5" "3847.8" "4006.1" "4332.4" "3812.1" "3857.6" "4121.6" "2626.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "119.497" "35" "23" "32" "23" "795" "87.1" "6.37" "116.13" "23" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "1.024" "0.981" "1.065" "1.023" "0.976" "1.057" "0.773" "0.941" "5.106" "1893.7" "1938.6" "1857.4" "2016.7" "1936.6" "1849.1" "2001.3" "1463.1" "1781.2" "9669.9" "" "" "" "" "" "" "" "" "" "" "1679.3" "1605.8" "1620.7" "1508.2" "1614.8" "1698.6" "1691.4" "1209.3" "1633.6" "9669.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "119.495" "25" "12" "61" "12" "443" "48.2" "8.66" "205.66" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "PTK6 Regulates Proteins Involved in RNA Processing" "Leptin signaling pathway; Primary ovarian insufficiency" "3" "0" "0.931" "0.943" "0.901" "0.890" "0.909" "0.895" "0.908" "0.923" "0.715" "6806.3" "6336.8" "6416.4" "6132.4" "6059.0" "6189.6" "6094.1" "6180.9" "6280.1" "4869.5" "" "" "" "" "" "" "" "" "" "" "6035.7" "5249.1" "5598.6" "4586.2" "5052.4" "5685.9" "5150.5" "5109.0" "5759.7" "4869.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "119.491" "39" "11" "75" "8" "249" "28.6" "4.09" "275.35" "11" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "HuR (ELAVL1) binds and stabilizes mRNA" "IL-18 signaling pathway" "2" "3" "1.016" "1.021" "1.003" "0.988" "1.042" "0.935" "0.985" "1.011" "0.553" "6952.9" "7062.3" "7098.5" "6974.2" "6868.3" "7246.6" "6498.1" "6846.1" "7031.7" "3847.4" "" "" "" "" "" "" "" "" "" "" "6165.7" "5850.0" "6193.8" "5215.8" "5727.2" "6656.8" "5492.0" "5658.8" "6449.1" "3847.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "119.487" "38" "13" "33" "13" "408" "44.9" "8.65" "132.52" "13" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "1" "0" "0.991" "0.989" "0.987" "1.048" "1.186" "1.157" "1.157" "1.183" "0.600" "3593.9" "3561.5" "3555.6" "3547.1" "3767.3" "4262.4" "4158.5" "4158.9" "4250.0" "2157.3" "" "" "" "" "" "" "" "" "" "" "3187.0" "2950.2" "3102.5" "2652.8" "3141.4" "3915.5" "3514.6" "3437.6" "3897.8" "2157.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "119.135" "74" "6" "40" "5" "127" "14.5" "5.38" "171.06" "6" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "1" "1.024" "1.033" "1.020" "1.023" "1.025" "1.028" "1.039" "1.072" "0.548" "4416.0" "4520.7" "4562.8" "4505.5" "4516.9" "4524.4" "4538.8" "4586.2" "4732.5" "2419.8" "" "" "" "" "" "" "" "" "" "" "3916.0" "3744.7" "3981.2" "3369.5" "3766.5" "4156.1" "3836.0" "3790.8" "4340.3" "2419.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "119.044" "59" "17" "24" "14" "335" "37.7" "5.15" "98.58" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "13" "3" "1.042" "1.015" "1.033" "1.117" "0.980" "0.970" "0.993" "1.020" "0.779" "3029.2" "3155.9" "3074.4" "3129.9" "3382.9" "2967.2" "2939.3" "3008.6" "3090.9" "2359.2" "" "" "" "" "" "" "" "" "" "" "2686.2" "2614.2" "2682.5" "2340.8" "2820.9" "2725.7" "2484.2" "2486.8" "2834.8" "2359.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "118.969" "34" "15" "42" "15" "471" "52.0" "8.00" "154.98" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; RHOBTB1 GTPase cycle" "" "5" "0" "1.019" "1.059" "1.043" "1.027" "1.036" "1.050" "1.039" "1.022" "0.787" "3134.0" "3194.5" "3318.2" "3268.6" "3218.7" "3247.4" "3290.8" "3255.1" "3201.9" "2464.9" "" "" "" "" "" "" "" "" "" "" "2779.2" "2646.2" "2895.3" "2444.5" "2683.9" "2983.1" "2781.2" "2690.6" "2936.6" "2464.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3854455294821174963" "False" "High" "IsMasterProtein" "Q969X6" "U3 small nucleolar RNA-associated protein 4 homolog OS=Homo sapiens OX=9606 GN=UTP4 PE=1 SV=1" "0.000" "False" "118.932" "33" "21" "32" "21" "686" "76.8" "8.85" "118.26" "21" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "84916" "ENSG00000141076; ENSG00000262788" "UTP4" "hsa:84916; Q8NCD9; Q8TF14; Q969X6; Q96SP0; Q96SR9; Q96SZ9; Q96T13; Q9BWK6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.067" "1.047" "1.021" "1.051" "1.027" "1.055" "1.043" "1.025" "0.230" "3369.9" "3594.9" "3528.7" "3442.1" "3541.7" "3460.3" "3556.6" "3515.6" "3453.1" "776.3" "" "" "" "" "" "" "" "" "" "" "2988.4" "2977.8" "3079.0" "2574.2" "2953.3" "3178.7" "3005.9" "2905.9" "3167.0" "776.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "118.844" "49" "14" "29" "14" "335" "36.0" "9.28" "122.47" "14" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "5" "0" "1.017" "0.998" "1.011" "1.015" "1.021" "0.893" "0.922" "0.865" "0.470" "3660.1" "3720.9" "3652.2" "3701.8" "3715.8" "3736.3" "3269.4" "3374.8" "3164.4" "1718.6" "" "" "" "" "" "" "" "" "" "" "3245.7" "3082.2" "3186.7" "2768.5" "3098.5" "3432.2" "2763.2" "2789.5" "2902.2" "1718.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "118.476" "77" "13" "48" "4" "201" "22.2" "5.73" "176.65" "13" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "COPII-mediated vesicle transport; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "0" "0.907" "0.801" "0.796" "0.713" "0.627" "0.626" "0.721" "0.775" "0.411" "3740.4" "3394.3" "2996.6" "2978.3" "2667.3" "2346.5" "2342.8" "2696.0" "2897.1" "1537.3" "" "" "" "" "" "" "" "" "" "" "3316.9" "2811.7" "2614.7" "2227.3" "2224.2" "2155.5" "1980.0" "2228.5" "2657.1" "1537.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "118.328" "33" "21" "26" "7" "662" "73.2" "7.18" "94.10" "21" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Neutrophil degranulation" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "3" "9" "1.014" "0.970" "1.002" "0.946" "0.950" "0.926" "0.575" "1.006" "7.355" "1869.4" "1895.1" "1812.4" "1872.9" "1768.0" "1775.7" "1731.6" "1074.1" "1881.5" "13749.4" "" "" "" "" "" "" "" "" "" "" "1657.8" "1569.8" "1581.4" "1400.7" "1474.3" "1631.1" "1463.5" "887.8" "1725.6" "13749.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "117.949" "14" "25" "30" "22" "1912" "217.9" "5.86" "105.10" "25" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "Rett syndrome; Effect of progerin on genes involved in progeria" "9" "3" "1.040" "0.949" "1.057" "0.979" "0.975" "0.906" "0.546" "0.926" "8.594" "1068.4" "1110.7" "1014.4" "1128.9" "1045.8" "1041.8" "968.1" "583.1" "989.6" "9181.7" "" "" "" "" "" "" "" "" "" "" "947.5" "920.0" "885.1" "844.3" "872.0" "957.0" "818.2" "482.0" "907.6" "9181.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "117.910" "39" "9" "26" "9" "324" "37.0" "6.77" "111.21" "9" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.953" "0.980" "1.020" "1.020" "1.035" "1.109" "1.122" "1.094" "0.746" "1603.9" "1529.3" "1571.5" "1636.4" "1636.6" "1660.8" "1778.0" "1800.0" "1754.2" "1196.4" "" "" "" "" "" "" "" "" "" "" "1422.3" "1266.8" "1371.2" "1223.8" "1364.7" "1525.6" "1502.7" "1487.8" "1608.8" "1196.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "117.584" "44" "14" "41" "10" "349" "39.5" "6.84" "156.40" "14" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "1.017" "1.061" "1.007" "1.030" "1.045" "0.958" "1.046" "0.965" "0.604" "4228.7" "4298.7" "4487.1" "4256.8" "4355.8" "4420.9" "4052.5" "4422.8" "4079.6" "2553.7" "" "" "" "" "" "" "" "" "" "" "3749.9" "3560.8" "3915.2" "3183.5" "3632.2" "4061.1" "3425.0" "3655.8" "3741.6" "2553.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "117.050" "36" "11" "28" "11" "363" "38.9" "5.07" "116.71" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "POLB-Dependent Long Patch Base Excision Repair" "" "1" "0" "1.052" "1.039" "1.001" "1.055" "1.051" "0.930" "1.007" "0.948" "0.737" "2577.1" "2711.3" "2676.7" "2579.1" "2720.1" "2707.3" "2397.7" "2596.1" "2441.9" "1900.4" "" "" "" "" "" "" "" "" "" "" "2285.3" "2245.9" "2335.5" "1928.8" "2268.2" "2486.9" "2026.5" "2145.9" "2239.5" "1900.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "116.818" "43" "10" "21" "10" "321" "35.9" "6.60" "93.93" "10" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "GDP-fucose biosynthesis" "" "1" "0" "1.034" "1.033" "1.091" "1.087" "1.091" "1.064" "1.089" "0.970" "0.519" "2268.8" "2345.4" "2342.6" "2475.8" "2465.9" "2475.6" "2413.5" "2471.1" "2201.6" "1177.1" "" "" "" "" "" "" "" "" "" "" "2011.9" "1942.8" "2044.1" "1851.6" "2056.2" "2274.1" "2039.8" "2042.5" "2019.2" "1177.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "116.778" "20" "18" "22" "18" "1081" "118.6" "4.96" "94.54" "18" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "1.013" "0.923" "1.029" "0.986" "0.953" "0.919" "0.628" "0.827" "5.257" "1938.0" "1964.1" "1788.8" "1994.2" "1911.6" "1847.8" "1781.5" "1216.8" "1603.3" "10188.2" "" "" "" "" "" "" "" "" "" "" "1718.6" "1627.0" "1560.8" "1491.4" "1594.1" "1697.4" "1505.7" "1005.8" "1470.4" "10188.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "116.761" "28" "13" "32" "13" "551" "59.2" "7.15" "118.17" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "0.968" "0.989" "0.969" "1.010" "1.013" "1.059" "1.080" "1.048" "0.489" "4385.3" "4243.1" "4337.6" "4250.5" "4430.9" "4441.4" "4645.1" "4736.1" "4596.7" "2144.8" "" "" "" "" "" "" "" "" "" "" "3888.8" "3514.7" "3784.7" "3178.8" "3694.8" "4080.0" "3925.9" "3914.7" "4215.8" "2144.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.000" "False" "116.724" "35" "9" "19" "9" "424" "44.3" "8.44" "95.40" "9" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "11" "0" "1.129" "1.052" "1.135" "1.078" "1.103" "1.089" "1.021" "0.968" "0.553" "1500.1" "1693.9" "1578.4" "1703.0" "1617.6" "1655.2" "1633.9" "1531.5" "1452.0" "828.9" "" "" "" "" "" "" "" "" "" "" "1330.2" "1403.2" "1377.2" "1273.6" "1348.9" "1520.5" "1380.9" "1265.9" "1331.7" "828.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "116.445" "27" "19" "30" "19" "704" "80.6" "6.64" "120.26" "19" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "Peptide ligand-binding receptors" "" "1" "0" "0.997" "1.027" "1.041" "1.033" "1.011" "1.097" "1.097" "1.069" "0.589" "4164.1" "4152.3" "4275.7" "4333.8" "4302.3" "4210.0" "4567.2" "4569.7" "4452.3" "2452.5" "" "" "" "" "" "" "" "" "" "" "3692.6" "3439.6" "3730.8" "3241.1" "3587.5" "3867.4" "3860.0" "3777.2" "4083.3" "2452.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4879961638611313513" "False" "High" "IsMasterProtein" "Q12765" "Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2" "0.000" "False" "116.036" "30" "11" "27" "11" "414" "46.4" "4.75" "109.04" "11" "protein metabolism;transport;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03577" "9805" "ENSG00000136193" "SCRN1" "A8K0E9; B4DHM0; B4DIP5; C9JPG0; hsa:9805; Q12765; Q25QX7; Q8IWD1" "" "" "0" "0" "0.901" "0.976" "0.891" "0.879" "0.929" "0.974" "0.963" "0.980" "1.240" "3070.2" "2765.4" "2997.2" "2736.5" "2697.5" "2853.3" "2988.9" "2957.8" "3009.9" "3808.0" "" "" "" "" "" "" "" "" "" "" "2722.6" "2290.7" "2615.2" "2046.6" "2249.3" "2621.1" "2526.1" "2444.9" "2760.5" "3808.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "115.620" "44" "12" "18" "12" "372" "42.0" "5.31" "87.17" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "17q12 copy number variation syndrome" "6" "0" "0.990" "0.985" "1.029" "1.017" "1.041" "1.070" "0.985" "1.024" "0.769" "1855.7" "1836.8" "1828.3" "1908.9" "1888.0" "1932.6" "1985.6" "1828.5" "1899.5" "1427.0" "" "" "" "" "" "" "" "" "" "" "1645.6" "1521.5" "1595.3" "1427.6" "1574.4" "1775.3" "1678.1" "1511.4" "1742.1" "1427.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "115.565" "52" "11" "41" "5" "207" "23.7" "9.07" "153.88" "11" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "10" "4" "0.944" "1.007" "0.990" "1.004" "1.068" "0.972" "1.034" "0.981" "0.703" "4272.8" "4035.4" "4300.9" "4228.4" "4290.2" "4561.8" "4154.7" "4420.0" "4189.5" "3004.3" "" "" "" "" "" "" "" "" "" "" "3789.0" "3342.7" "3752.8" "3162.3" "3577.5" "4190.5" "3511.4" "3653.4" "3842.3" "3004.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "115.449" "34" "20" "23" "19" "780" "86.1" "5.27" "98.44" "20" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "MET in type 1 papillary renal cell carcinoma" "8" "1" "1.016" "0.996" "1.035" "1.037" "1.024" "1.061" "1.039" "1.059" "0.726" "1786.5" "1814.3" "1779.2" "1849.2" "1852.5" "1829.1" "1895.9" "1856.8" "1891.6" "1297.5" "" "" "" "" "" "" "" "" "" "" "1584.2" "1502.9" "1552.4" "1383.0" "1544.8" "1680.2" "1602.3" "1534.8" "1734.8" "1297.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9112301912693417232" "False" "High" "IsMasterProtein" "Q13332" "Receptor-type tyrosine-protein phosphatase S OS=Homo sapiens OX=9606 GN=PTPRS PE=1 SV=3" "0.000" "False" "114.862" "14" "18" "21" "18" "1948" "216.9" "6.46" "97.93" "18" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf00102, Pf07679, Pf13927" "5802" "ENSG00000105426" "PTPRS" "hsa:5802; O75255; O75870; Q13332; Q15718; Q16341; Q2M3R7" "Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases; ECM proteoglycans; Signaling by NTRK3 (TRKC)" "" "4" "0" "1.125" "0.947" "1.100" "1.073" "0.933" "1.021" "0.992" "0.947" "0.835" "1669.7" "1878.0" "1580.5" "1836.1" "1791.7" "1557.1" "1704.0" "1655.7" "1581.9" "1394.9" "" "" "" "" "" "" "" "" "" "" "1480.7" "1555.7" "1379.1" "1373.1" "1494.0" "1430.3" "1440.2" "1368.6" "1450.8" "1394.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5402029241356858044" "False" "High" "IsMasterProtein" "P09936" "Ubiquitin carboxyl-terminal hydrolase isozyme L1 OS=Homo sapiens OX=9606 GN=UCHL1 PE=1 SV=2" "0.000" "False" "114.789" "49" "9" "42" "9" "223" "24.8" "5.48" "183.42" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01088" "7345" "ENSG00000154277" "UCHL1" "hsa:7345; P09936; Q4W5K6; Q71UM0" "UCH proteinases" "Proteasome degradation; Parkinson's disease pathway; Hepatitis C and hepatocellular carcinoma" "4" "0" "0.982" "0.975" "0.931" "0.929" "0.972" "0.977" "1.010" "1.009" "0.560" "5845.6" "5740.3" "5701.5" "5441.2" "5429.2" "5680.1" "5712.7" "5906.5" "5897.6" "3276.4" "" "" "" "" "" "" "" "" "" "" "5183.8" "4755.0" "4974.8" "4069.3" "4527.2" "5217.8" "4828.1" "4882.2" "5408.9" "3276.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "114.740" "41" "12" "19" "11" "380" "42.6" "8.62" "90.04" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "Base excision repair; DNA repair pathways, full network" "8" "0" "0.966" "0.879" "0.975" "0.910" "0.808" "1.014" "0.552" "0.973" "8.340" "1139.3" "1100.2" "1001.2" "1111.1" "1037.0" "920.8" "1154.8" "628.9" "1108.8" "9502.1" "" "" "" "" "" "" "" "" "" "" "1010.3" "911.3" "873.6" "830.9" "864.7" "845.8" "976.0" "519.8" "1016.9" "9502.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "114.683" "40" "12" "25" "12" "335" "37.4" "5.39" "104.43" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "Iron uptake and transport" "" "1" "0" "1.064" "1.082" "0.931" "0.983" "1.043" "0.926" "0.921" "0.941" "1.881" "2640.7" "2808.9" "2856.3" "2459.4" "2594.8" "2754.6" "2446.2" "2433.3" "2484.0" "4968.3" "" "" "" "" "" "" "" "" "" "" "2341.7" "2326.8" "2492.2" "1839.3" "2163.7" "2530.4" "2067.4" "2011.3" "2278.2" "4968.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "114.388" "19" "18" "29" "18" "1041" "115.9" "4.81" "113.05" "18" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "1.067" "1.041" "1.092" "1.089" "1.173" "0.918" "0.958" "0.855" "0.946" "2513.8" "2681.3" "2616.9" "2745.4" "2737.5" "2948.4" "2308.2" "2407.9" "2150.2" "2378.5" "" "" "" "" "" "" "" "" "" "" "2229.2" "2221.1" "2283.4" "2053.2" "2282.7" "2708.4" "1950.8" "1990.3" "1972.0" "2378.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "114.320" "18" "24" "30" "24" "1312" "153.8" "6.89" "112.52" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "29" "0" "1.270" "1.000" "1.043" "1.052" "1.066" "0.960" "0.857" "0.919" "2.058" "3297.5" "4188.9" "3296.5" "3439.3" "3469.7" "3515.1" "3166.4" "2824.3" "3030.4" "6786.2" "" "" "" "" "" "" "" "" "" "" "2924.1" "3469.9" "2876.4" "2572.2" "2893.2" "3229.0" "2676.1" "2334.5" "2779.3" "6786.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "114.132" "33" "13" "25" "13" "529" "57.8" "5.40" "113.96" "13" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "" "8" "0" "1.073" "1.000" "1.155" "1.066" "1.058" "1.082" "0.463" "1.084" "10.856" "1554.4" "1667.3" "1553.9" "1795.2" "1657.3" "1645.1" "1682.4" "720.3" "1685.2" "16874.8" "" "" "" "" "" "" "" "" "" "" "1378.4" "1381.1" "1355.9" "1342.6" "1382.0" "1511.2" "1421.9" "595.4" "1545.6" "16874.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "114.125" "54" "17" "44" "17" "224" "24.9" "4.82" "161.26" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "0.922" "0.962" "0.841" "0.952" "0.975" "0.905" "0.991" "1.032" "0.423" "7181.8" "6623.3" "6912.0" "6041.2" "6839.9" "7004.4" "6497.0" "7120.4" "7412.5" "3038.1" "" "" "" "" "" "" "" "" "" "" "6368.7" "5486.4" "6031.0" "4518.1" "5703.6" "6434.3" "5491.0" "5885.5" "6798.3" "3038.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "114.102" "22" "21" "29" "21" "1074" "116.9" "9.04" "117.46" "21" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "" "Exercise-induced circadian regulation" "1" "0" "0.975" "0.959" "0.996" "0.985" "0.945" "1.001" "0.971" "1.001" "1.454" "2764.0" "2694.1" "2651.8" "2751.7" "2722.7" "2611.7" "2765.7" "2682.9" "2768.0" "4018.7" "" "" "" "" "" "" "" "" "" "" "2451.0" "2231.7" "2313.8" "2057.9" "2270.3" "2399.2" "2337.4" "2217.6" "2538.7" "4018.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "113.874" "53" "14" "30" "14" "291" "31.8" "5.19" "97.30" "14" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.064" "1.037" "1.108" "1.070" "1.055" "1.082" "1.083" "1.014" "0.461" "2142.4" "2278.5" "2222.6" "2372.8" "2292.0" "2260.5" "2318.0" "2320.2" "2171.4" "986.9" "" "" "" "" "" "" "" "" "" "" "1899.8" "1887.4" "1939.4" "1774.5" "1911.2" "2076.5" "1959.1" "1917.8" "1991.5" "986.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "113.867" "32" "20" "30" "20" "665" "75.7" "6.84" "116.52" "20" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "1.026" "1.009" "0.943" "0.929" "0.991" "0.939" "0.815" "0.991" "3.255" "3098.0" "3178.3" "3126.5" "2922.4" "2877.7" "3069.1" "2908.2" "2524.3" "3071.5" "10082.5" "" "" "" "" "" "" "" "" "" "" "2747.3" "2632.7" "2728.1" "2185.5" "2399.6" "2819.3" "2457.9" "2086.5" "2817.0" "10082.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "113.614" "38" "15" "25" "15" "523" "57.5" "9.38" "92.51" "15" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Recycling of eIF2:GDP" "Translation factors; Primary ovarian insufficiency" "3" "0" "0.926" "0.962" "0.924" "0.919" "0.897" "1.078" "1.102" "1.084" "1.019" "1551.5" "1437.0" "1492.6" "1433.8" "1425.5" "1392.0" "1672.8" "1709.8" "1682.6" "1580.2" "" "" "" "" "" "" "" "" "" "" "1375.8" "1190.4" "1302.3" "1072.3" "1188.7" "1278.8" "1413.8" "1413.3" "1543.2" "1580.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "113.564" "60" "9" "20" "9" "245" "26.6" "4.68" "90.61" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "2" "0" "1.023" "0.987" "1.077" "1.092" "1.154" "1.203" "1.238" "1.016" "0.483" "2150.7" "2199.2" "2122.3" "2316.2" "2348.6" "2481.5" "2587.5" "2663.6" "2185.4" "1039.1" "" "" "" "" "" "" "" "" "" "" "1907.2" "1821.7" "1851.8" "1732.2" "1958.4" "2279.5" "2186.8" "2201.7" "2004.3" "1039.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4770714879888361237" "False" "High" "IsMasterProtein" "Q5GLZ8" "Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1" "0.000" "False" "113.471" "23" "21" "27" "21" "1057" "118.5" "6.19" "108.22" "21" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632" "26091" "ENSG00000148634" "HERC4" "hsa:26091; Q5GC98; Q5GC99; Q5GCA0; Q5GLZ8; Q8IXP9; Q9HCH9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.012" "1.006" "1.024" "0.998" "0.990" "1.019" "1.018" "0.941" "1.296" "2722.4" "2754.0" "2739.0" "2788.2" "2718.3" "2695.3" "2775.3" "2771.5" "2562.4" "3528.8" "" "" "" "" "" "" "" "" "" "" "2414.1" "2281.3" "2389.9" "2085.2" "2266.7" "2476.0" "2345.5" "2290.8" "2350.1" "3528.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "113.322" "21" "14" "29" "14" "802" "85.1" "6.79" "112.32" "14" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "1.000" "0.982" "1.074" "1.063" "0.999" "1.046" "1.032" "0.917" "0.607" "3076.0" "3077.3" "3022.0" "3302.5" "3270.2" "3073.2" "3218.5" "3174.7" "2820.7" "1867.1" "" "" "" "" "" "" "" "" "" "" "2727.7" "2549.1" "2636.9" "2469.9" "2726.9" "2823.1" "2720.1" "2624.1" "2587.0" "1867.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "113.307" "62" "14" "50" "14" "197" "22.6" "7.11" "176.45" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.943" "0.942" "0.888" "0.914" "0.970" "0.890" "0.933" "0.940" "0.507" "9263.5" "8737.8" "8730.1" "8228.4" "8469.0" "8988.9" "8243.8" "8646.7" "8709.1" "4700.2" "" "" "" "" "" "" "" "" "" "" "8214.7" "7238.0" "7617.5" "6153.7" "7062.0" "8257.3" "6967.3" "7147.1" "7987.4" "4700.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "113.276" "35" "9" "21" "9" "351" "38.5" "7.37" "106.94" "9" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.027" "1.020" "1.071" "1.015" "1.012" "0.996" "0.994" "0.988" "1.004" "2979.6" "3059.8" "3038.8" "3191.0" "3024.6" "3015.1" "2968.4" "2963.0" "2943.9" "2991.9" "" "" "" "" "" "" "" "" "" "" "2642.3" "2534.6" "2651.5" "2386.4" "2522.1" "2769.7" "2508.8" "2449.1" "2700.0" "2991.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "113.094" "38" "9" "22" "9" "380" "41.6" "5.27" "106.28" "9" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "0.999" "1.001" "0.933" "1.003" "1.006" "0.936" "0.951" "0.965" "0.665" "1539.0" "1537.1" "1540.3" "1436.3" "1543.2" "1547.6" "1440.4" "1464.2" "1484.9" "1023.4" "" "" "" "" "" "" "" "" "" "" "1364.8" "1273.3" "1344.0" "1074.2" "1286.9" "1421.7" "1217.3" "1210.2" "1361.9" "1023.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "113.093" "59" "9" "41" "9" "214" "22.1" "8.70" "168.27" "9" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "" "Selenium micronutrient network" "1" "0" "0.972" "1.062" "0.996" "0.996" "0.984" "1.046" "1.053" "1.022" "0.440" "5531.3" "5374.7" "5875.2" "5507.4" "5507.8" "5440.7" "5785.1" "5823.3" "5653.5" "2431.5" "" "" "" "" "" "" "" "" "" "" "4905.1" "4452.1" "5126.4" "4118.8" "4592.8" "4997.9" "4889.4" "4813.4" "5185.1" "2431.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "113.035" "69" "10" "42" "10" "178" "18.9" "7.49" "150.16" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "0.913" "0.899" "0.867" "0.863" "0.820" "0.756" "0.868" "0.902" "0.419" "6328.2" "5774.7" "5688.8" "5488.2" "5461.4" "5190.4" "4785.3" "5494.5" "5706.2" "2654.7" "" "" "" "" "" "" "" "" "" "" "5611.7" "4783.5" "4963.7" "4104.4" "4554.1" "4768.0" "4044.4" "4541.6" "5233.4" "2654.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "112.989" "72" "11" "33" "11" "165" "17.8" "9.42" "139.94" "11" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.056" "1.134" "1.069" "1.174" "1.252" "1.177" "1.155" "1.226" "0.286" "3412.9" "3602.5" "3871.3" "3649.2" "4005.3" "4274.3" "4016.7" "3941.1" "4184.6" "976.9" "" "" "" "" "" "" "" "" "" "" "3026.5" "2984.2" "3377.9" "2729.1" "3339.9" "3926.4" "3394.8" "3257.6" "3837.8" "976.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "112.958" "30" "14" "24" "12" "522" "59.0" "5.15" "95.53" "14" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "0.890" "0.938" "0.987" "0.961" "0.844" "1.213" "0.914" "1.083" "5.023" "1801.0" "1602.4" "1689.3" "1776.9" "1730.6" "1520.1" "2183.9" "1647.0" "1951.4" "9046.1" "" "" "" "" "" "" "" "" "" "" "1597.1" "1327.4" "1474.0" "1328.9" "1443.1" "1396.4" "1845.7" "1361.4" "1789.7" "9046.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6750207652327358618" "False" "High" "IsMasterProtein" "O43719" "17S U2 SnRNP complex component HTATSF1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "0.000" "False" "112.877" "34" "25" "31" "25" "755" "85.8" "4.40" "107.61" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "mRNA Splicing - Major Pathway" "" "1" "0" "0.941" "0.913" "0.887" "0.842" "0.949" "0.871" "0.701" "0.896" "4.925" "3783.6" "3561.1" "3456.2" "3355.8" "3184.9" "3591.5" "3294.7" "2651.1" "3388.7" "18634.1" "" "" "" "" "" "" "" "" "" "" "3355.2" "2949.8" "3015.7" "2509.7" "2655.8" "3299.2" "2784.5" "2191.3" "3107.9" "18634.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "112.835" "27" "25" "36" "25" "972" "112.2" "6.64" "128.47" "25" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "0.831" "0.840" "0.806" "0.840" "0.793" "0.869" "0.883" "0.856" "0.751" "5490.9" "4564.4" "4612.9" "4424.0" "4614.2" "4354.7" "4771.3" "4845.9" "4702.2" "4124.9" "" "" "" "" "" "" "" "" "" "" "4869.2" "3780.9" "4025.0" "3308.6" "3847.6" "4000.3" "4032.5" "4005.4" "4312.6" "4124.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "112.814" "39" "11" "24" "11" "376" "42.5" "6.84" "87.72" "11" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "1.063" "1.039" "1.120" "1.114" "1.070" "1.101" "1.080" "1.024" "0.701" "1892.9" "2011.6" "1967.3" "2120.2" "2108.4" "2025.0" "2083.8" "2043.8" "1938.8" "1326.1" "" "" "" "" "" "" "" "" "" "" "1678.6" "1666.3" "1716.6" "1585.6" "1758.1" "1860.1" "1761.1" "1689.4" "1778.1" "1326.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "112.779" "41" "14" "32" "14" "406" "46.9" "5.26" "122.60" "14" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "Neutrophil degranulation" "" "1" "0" "1.078" "0.997" "1.009" "1.040" "1.091" "0.846" "0.857" "0.820" "0.704" "3097.4" "3339.6" "3088.9" "3123.7" "3219.8" "3378.2" "2621.5" "2654.8" "2538.9" "2181.9" "" "" "" "" "" "" "" "" "" "" "2746.7" "2766.3" "2695.2" "2336.1" "2684.9" "3103.3" "2215.6" "2194.4" "2328.5" "2181.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "112.410" "50" "11" "34" "11" "224" "25.2" "9.28" "140.25" "11" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "0.879" "0.857" "0.837" "0.773" "0.758" "0.716" "0.813" "0.845" "0.459" "6499.7" "5710.5" "5568.9" "5443.2" "5025.5" "4929.8" "4654.6" "5281.7" "5491.2" "2981.7" "" "" "" "" "" "" "" "" "" "" "5763.8" "4730.3" "4859.1" "4070.8" "4190.6" "4528.5" "3933.9" "4365.7" "5036.2" "2981.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "112.386" "27" "16" "31" "16" "706" "79.1" "6.32" "118.13" "16" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "Miscellaneous transport and binding events; RHOD GTPase cycle; RHOF GTPase cycle" "" "3" "0" "1.008" "1.027" "1.058" "1.049" "1.026" "1.049" "1.050" "0.981" "0.557" "3525.5" "3553.5" "3621.4" "3729.0" "3697.9" "3615.8" "3698.7" "3700.0" "3457.0" "1963.2" "" "" "" "" "" "" "" "" "" "" "3126.3" "2943.5" "3159.9" "2788.8" "3083.5" "3321.5" "3126.0" "3058.3" "3170.5" "1963.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "112.198" "47" "16" "31" "15" "385" "42.2" "8.46" "118.10" "16" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "Citric acid cycle (TCA cycle)" "TCA cycle (aka Krebs or citric acid cycle)" "2" "0" "1.018" "1.028" "0.990" "1.013" "1.011" "0.978" "1.058" "0.973" "0.725" "2705.8" "2753.6" "2781.1" "2678.8" "2741.3" "2735.5" "2647.4" "2861.7" "2631.5" "1961.9" "" "" "" "" "" "" "" "" "" "" "2399.4" "2280.9" "2426.7" "2003.4" "2285.9" "2512.9" "2237.5" "2365.4" "2413.5" "1961.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "112.007" "24" "17" "27" "17" "717" "82.9" "8.12" "108.95" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "0.994" "1.017" "0.971" "0.982" "0.960" "1.104" "1.100" "1.041" "0.785" "3689.3" "3668.5" "3750.2" "3584.0" "3621.5" "3540.0" "4073.3" "4057.9" "3840.0" "2894.5" "" "" "" "" "" "" "" "" "" "" "3271.6" "3038.8" "3272.2" "2680.3" "3019.8" "3251.9" "3442.6" "3354.1" "3521.8" "2894.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "111.803" "36" "11" "16" "11" "432" "47.5" "6.99" "72.93" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "Valproic acid pathway" "3" "0" "0.983" "1.024" "1.007" "1.060" "1.125" "1.065" "1.158" "1.076" "0.555" "2325.7" "2287.2" "2380.5" "2341.2" "2464.7" "2615.6" "2476.7" "2692.7" "2503.3" "1290.2" "" "" "" "" "" "" "" "" "" "" "2062.4" "1894.6" "2077.1" "1750.9" "2055.2" "2402.7" "2093.2" "2225.7" "2295.9" "1290.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "111.652" "25" "17" "23" "17" "900" "101.1" "6.16" "92.60" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "" "2" "0" "1.076" "0.960" "1.126" "1.007" "0.933" "1.224" "0.617" "1.192" "11.097" "935.6" "1006.6" "897.9" "1053.1" "941.9" "872.5" "1145.3" "576.8" "1115.0" "10382.1" "" "" "" "" "" "" "" "" "" "" "829.7" "833.8" "783.5" "787.6" "785.4" "801.5" "967.9" "476.8" "1022.6" "10382.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "111.635" "27" "18" "24" "18" "833" "91.2" "8.34" "91.91" "18" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "14" "0" "0.897" "0.972" "0.944" "0.900" "0.884" "1.047" "0.964" "1.050" "2.363" "1421.4" "1274.3" "1381.2" "1341.8" "1279.2" "1256.4" "1488.6" "1370.2" "1492.1" "3359.1" "" "" "" "" "" "" "" "" "" "" "1260.4" "1055.5" "1205.1" "1003.5" "1066.7" "1154.2" "1258.1" "1132.5" "1368.5" "3359.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "111.473" "24" "12" "54" "9" "526" "53.4" "9.36" "207.74" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "5" "3" "0.955" "0.965" "0.924" "0.924" "0.963" "0.903" "0.980" "0.970" "0.472" "7846.7" "7495.1" "7573.5" "7246.5" "7248.6" "7555.9" "7085.6" "7687.5" "7609.1" "3705.2" "" "" "" "" "" "" "" "" "" "" "6958.3" "6208.6" "6608.2" "5419.4" "6044.4" "6941.0" "5988.5" "6354.2" "6978.6" "3705.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285905538601848760" "False" "High" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.000" "False" "111.353" "17" "17" "22" "17" "1235" "135.3" "4.60" "86.60" "17" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "HATs acetylate histones" "" "1" "0" "0.987" "0.984" "0.977" "0.967" "1.002" "0.934" "0.897" "0.912" "1.061" "1452.1" "1433.6" "1428.6" "1418.6" "1403.9" "1454.8" "1355.8" "1302.4" "1324.4" "1540.6" "" "" "" "" "" "" "" "" "" "" "1287.7" "1187.5" "1246.5" "1060.9" "1170.7" "1336.4" "1145.9" "1076.5" "1214.7" "1540.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "111.182" "47" "13" "21" "13" "390" "42.9" "8.72" "93.50" "13" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial Fatty Acid Beta-Oxidation" "Mitochondrial fatty acid synthesis pathway" "2" "0" "1.024" "0.992" "1.103" "1.075" "1.064" "1.125" "1.054" "1.009" "0.542" "1134.0" "1161.7" "1125.2" "1250.9" "1218.6" "1207.0" "1276.2" "1195.8" "1144.4" "614.1" "" "" "" "" "" "" "" "" "" "" "1005.6" "962.3" "981.8" "935.5" "1016.1" "1108.7" "1078.6" "988.4" "1049.5" "614.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "110.991" "28" "11" "21" "11" "450" "50.8" "7.43" "87.16" "11" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "1.066" "1.030" "1.009" "1.108" "1.144" "1.054" "1.072" "0.964" "0.545" "1745.3" "1860.5" "1797.4" "1760.3" "1933.6" "1996.9" "1838.9" "1871.6" "1682.3" "951.9" "" "" "" "" "" "" "" "" "" "" "1547.7" "1541.1" "1568.3" "1316.5" "1612.4" "1834.4" "1554.2" "1547.0" "1542.9" "951.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "110.936" "61" "9" "40" "9" "193" "20.6" "8.57" "158.74" "9" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MTF1 activates gene expression" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "3" "0" "0.944" "0.990" "0.948" "0.984" "1.026" "1.012" "1.076" "1.034" "0.458" "5608.7" "5296.5" "5550.8" "5319.0" "5518.3" "5753.2" "5677.5" "6035.4" "5797.3" "2569.9" "" "" "" "" "" "" "" "" "" "" "4973.7" "4387.4" "4843.4" "3977.9" "4601.5" "5284.9" "4798.4" "4988.7" "5317.0" "2569.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097285546309815512" "False" "High" "IsMasterProtein" "Q8NEB9" "Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1" "0.000" "False" "110.791" "20" "16" "25" "16" "887" "101.5" "6.81" "96.65" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792" "5289" "ENSG00000078142" "PIK3C3" "hsa:5289; Q15134; Q8NEB9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "AMP-activated protein kinase signaling; Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Microglia pathogen phagocytosis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "24" "0" "1.038" "0.996" "1.069" "1.071" "1.012" "1.078" "1.052" "1.052" "1.459" "1940.6" "2014.1" "1933.1" "2073.7" "2077.8" "1964.7" "2092.1" "2040.8" "2041.4" "2830.5" "" "" "" "" "" "" "" "" "" "" "1720.9" "1668.3" "1686.7" "1550.9" "1732.6" "1804.8" "1768.2" "1686.9" "1872.2" "2830.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "110.718" "48" "7" "35" "7" "183" "20.3" "4.72" "139.85" "7" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "0.964" "0.994" "0.990" "0.988" "0.987" "0.897" "1.033" "0.977" "0.442" "3192.1" "3075.9" "3173.6" "3159.2" "3153.5" "3150.6" "2863.6" "3298.6" "3119.5" "1409.5" "" "" "" "" "" "" "" "" "" "" "2830.7" "2547.9" "2769.1" "2362.7" "2629.6" "2894.2" "2420.2" "2726.5" "2861.0" "1409.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "110.494" "27" "25" "30" "15" "977" "107.5" "7.03" "98.44" "25" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "21" "7" "0.995" "0.973" "1.000" "0.981" "0.961" "1.000" "0.956" "0.876" "0.926" "2442.5" "2430.5" "2376.1" "2441.7" "2395.5" "2348.0" "2441.6" "2334.4" "2138.7" "2262.1" "" "" "" "" "" "" "" "" "" "" "2166.0" "2013.3" "2073.2" "1826.1" "1997.5" "2156.9" "2063.5" "1929.6" "1961.5" "2262.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "110.395" "45" "17" "33" "17" "389" "43.8" "6.92" "101.35" "17" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "5" "0" "1.035" "0.998" "1.034" "1.047" "1.064" "1.058" "1.053" "0.976" "0.528" "1654.6" "1712.9" "1652.0" "1710.9" "1732.7" "1761.0" "1750.2" "1742.6" "1615.8" "874.0" "" "" "" "" "" "" "" "" "" "" "1467.3" "1418.9" "1441.4" "1279.5" "1444.8" "1617.6" "1479.2" "1440.4" "1481.9" "874.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "110.347" "52" "13" "43" "12" "316" "35.8" "6.98" "160.22" "13" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Pregnenolone biosynthesis; Fructose biosynthesis" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "7" "0" "0.998" "1.055" "1.011" "1.009" "1.048" "1.024" "1.086" "1.006" "0.485" "3667.4" "3660.1" "3867.5" "3708.0" "3702.1" "3841.9" "3754.3" "3982.3" "3690.7" "1779.6" "" "" "" "" "" "" "" "" "" "" "3252.2" "3031.8" "3374.6" "2773.1" "3087.1" "3529.2" "3173.0" "3291.7" "3384.9" "1779.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "110.345" "29" "21" "28" "17" "859" "97.1" "9.19" "92.49" "21" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; Pre-NOTCH Transcription and Translation; MAPK6/MAPK4 signaling; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "24" "2" "1.012" "0.981" "1.036" "1.017" "0.968" "1.031" "0.967" "1.029" "0.739" "2263.6" "2291.5" "2220.2" "2344.6" "2302.5" "2191.5" "2334.0" "2189.2" "2328.4" "1673.2" "" "" "" "" "" "" "" "" "" "" "2007.3" "1898.1" "1937.2" "1753.4" "1920.0" "2013.1" "1972.6" "1809.5" "2135.5" "1673.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "110.306" "42" "10" "24" "10" "289" "32.2" "4.96" "98.92" "10" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "" "7" "0" "1.011" "1.030" "0.915" "0.927" "0.910" "0.882" "0.772" "0.861" "2.325" "3023.8" "3056.2" "3116.0" "2767.9" "2801.6" "2750.8" "2666.1" "2335.0" "2603.1" "7030.9" "" "" "" "" "" "" "" "" "" "" "2681.5" "2531.6" "2718.9" "2070.0" "2336.1" "2526.9" "2253.2" "1930.1" "2387.4" "7030.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "110.304" "42" "10" "23" "10" "314" "34.6" "8.24" "94.75" "10" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "1.057" "0.992" "1.074" "1.080" "1.059" "1.044" "1.047" "1.017" "0.574" "2084.5" "2202.6" "2067.2" "2238.5" "2252.0" "2207.7" "2176.9" "2182.5" "2120.0" "1195.8" "" "" "" "" "" "" "" "" "" "" "1848.5" "1824.5" "1803.7" "1674.1" "1877.8" "2028.0" "1839.8" "1803.9" "1944.3" "1195.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "110.268" "10" "24" "25" "22" "2863" "318.9" "5.60" "89.73" "24" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "1" "1.002" "0.971" "1.043" "0.966" "0.899" "1.059" "0.909" "0.984" "2.326" "1648.9" "1651.9" "1601.4" "1719.2" "1592.3" "1482.0" "1746.2" "1498.4" "1622.4" "3835.4" "" "" "" "" "" "" "" "" "" "" "1462.2" "1368.3" "1397.3" "1285.7" "1327.8" "1361.4" "1475.9" "1238.5" "1488.0" "3835.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "109.963" "31" "21" "27" "21" "718" "83.1" "5.17" "103.48" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "1.023" "0.978" "0.953" "0.979" "1.007" "1.022" "1.019" "1.090" "1.606" "2026.5" "2072.4" "1981.2" "1931.1" "1983.1" "2039.7" "2070.1" "2065.6" "2209.6" "3253.8" "" "" "" "" "" "" "" "" "" "" "1797.0" "1716.7" "1728.7" "1444.2" "1653.7" "1873.7" "1749.5" "1707.4" "2026.5" "3253.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "109.629" "34" "14" "19" "14" "463" "51.8" "5.45" "80.59" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "Hijack of ubiquitination by SARS-CoV-2" "5" "0" "0.957" "0.984" "1.040" "1.022" "0.953" "1.290" "1.113" "1.117" "3.052" "1717.8" "1643.3" "1690.9" "1787.3" "1755.8" "1636.3" "2215.3" "1911.4" "1919.1" "5242.7" "" "" "" "" "" "" "" "" "" "" "1523.3" "1361.2" "1475.4" "1336.7" "1464.1" "1503.1" "1872.3" "1579.9" "1760.1" "5242.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9193943049168300683" "False" "High" "IsMasterProtein" "Q02818" "Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4" "0.000" "False" "109.556" "47" "18" "30" "18" "461" "53.8" "5.25" "124.13" "18" "signal transduction" "ER/Golgi" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "" "4924" "ENSG00000104805" "NUCB1" "B2RD64; hsa:4924; Q02818; Q15838; Q7Z4J7; Q9BUR1" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "1.076" "1.012" "1.011" "1.058" "1.110" "0.817" "0.879" "0.944" "0.596" "2986.8" "3212.8" "3023.6" "3020.0" "3158.8" "3314.6" "2439.1" "2625.9" "2819.0" "1778.9" "" "" "" "" "" "" "" "" "" "" "2648.6" "2661.3" "2638.3" "2258.6" "2634.0" "3044.8" "2061.4" "2170.5" "2585.4" "1778.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "109.537" "42" "7" "37" "7" "224" "24.3" "4.83" "191.39" "7" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.950" "0.953" "0.924" "0.918" "0.984" "0.930" "0.919" "0.945" "0.507" "6388.8" "6066.6" "6091.4" "5905.2" "5864.4" "6284.7" "5940.4" "5873.8" "6039.3" "3239.8" "" "" "" "" "" "" "" "" "" "" "5665.5" "5025.3" "5315.1" "4416.3" "4890.1" "5773.2" "5020.6" "4855.1" "5538.9" "3239.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.000" "False" "109.510" "10" "25" "25" "25" "2610" "289.2" "5.35" "91.83" "25" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.063" "1.052" "1.007" "0.993" "0.976" "1.084" "0.928" "1.064" "3.952" "1730.8" "1839.8" "1821.0" "1743.3" "1718.3" "1690.1" "1875.6" "1606.5" "1841.8" "6839.8" "" "" "" "" "" "" "" "" "" "" "1534.8" "1524.0" "1588.9" "1303.7" "1432.8" "1552.5" "1585.2" "1327.9" "1689.2" "6839.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "109.470" "61" "14" "34" "14" "243" "26.7" "9.66" "124.25" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.006" "0.996" "1.080" "1.070" "0.923" "0.995" "0.919" "0.916" "2.016" "3230.9" "3251.2" "3218.7" "3490.5" "3455.8" "2980.7" "3216.0" "2970.8" "2961.0" "6512.6" "" "" "" "" "" "" "" "" "" "" "2865.1" "2693.1" "2808.4" "2610.5" "2881.6" "2738.1" "2718.1" "2455.6" "2715.7" "6512.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "109.384" "46" "13" "25" "13" "397" "44.8" "7.08" "117.35" "13" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "4" "0" "0.982" "0.898" "0.910" "0.892" "0.813" "0.896" "0.845" "0.969" "2.158" "1963.5" "1927.4" "1762.4" "1785.8" "1752.0" "1596.7" "1759.6" "1659.1" "1902.3" "4237.4" "" "" "" "" "" "" "" "" "" "" "1741.1" "1596.5" "1537.8" "1335.5" "1460.9" "1466.7" "1487.1" "1371.3" "1744.6" "4237.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "109.049" "36" "9" "36" "7" "282" "31.3" "9.83" "170.87" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "2" "0.952" "0.906" "0.902" "0.866" "0.831" "0.847" "0.914" "0.853" "0.426" "6330.8" "6025.4" "5733.0" "5709.5" "5481.8" "5259.1" "5363.7" "5788.7" "5399.3" "2696.9" "" "" "" "" "" "" "" "" "" "" "5614.0" "4991.1" "5002.3" "4269.9" "4571.0" "4831.1" "4533.2" "4784.8" "4951.9" "2696.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "108.972" "33" "15" "20" "15" "667" "75.9" "6.98" "78.03" "15" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Platelet degranulation" "Leukocyte-intrinsic Hippo pathway functions" "2" "0" "1.014" "0.936" "1.162" "1.023" "0.943" "1.056" "1.065" "0.952" "1.995" "1649.5" "1672.1" "1544.3" "1916.3" "1687.7" "1556.3" "1742.2" "1756.3" "1570.9" "3291.0" "" "" "" "" "" "" "" "" "" "" "1462.7" "1385.1" "1347.5" "1433.2" "1407.3" "1429.6" "1472.4" "1451.7" "1440.8" "3291.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "108.904" "44" "11" "29" "11" "205" "22.9" "6.55" "121.68" "11" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Downstream TCR signaling; Interleukin-1 signaling; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.079" "1.111" "1.094" "1.115" "1.122" "1.114" "1.129" "1.053" "0.613" "4220.1" "4554.2" "4689.7" "4618.0" "4705.2" "4736.8" "4701.8" "4765.4" "4445.8" "2587.8" "" "" "" "" "" "" "" "" "" "" "3742.3" "3772.4" "4092.0" "3453.7" "3923.5" "4351.3" "3973.8" "3939.0" "4077.4" "2587.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "108.848" "27" "23" "30" "21" "765" "90.7" "9.31" "103.57" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "SUMOylation of DNA replication proteins" "Ebola virus infection in host; 15q25 copy number variation" "3" "0" "1.075" "1.015" "1.050" "1.029" "1.064" "1.019" "0.657" "0.951" "6.493" "1707.8" "1835.1" "1732.7" "1793.6" "1757.3" "1817.1" "1740.0" "1122.0" "1623.5" "11088.3" "" "" "" "" "" "" "" "" "" "" "1514.4" "1520.1" "1511.9" "1341.3" "1465.3" "1669.2" "1470.5" "927.4" "1489.0" "11088.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "108.748" "32" "13" "39" "13" "400" "43.4" "7.23" "134.72" "13" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "11" "0" "1.087" "1.040" "1.055" "1.092" "1.049" "1.096" "1.123" "1.016" "0.589" "4758.0" "5169.8" "4949.5" "5021.6" "5196.4" "4990.2" "5216.2" "5341.8" "4836.3" "2800.9" "" "" "" "" "" "" "" "" "" "" "4219.3" "4282.4" "4318.7" "3755.5" "4333.1" "4584.0" "4408.5" "4415.3" "4435.6" "2800.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "108.636" "35" "19" "30" "17" "522" "58.7" "6.33" "115.61" "19" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "1" "1.004" "1.020" "1.103" "1.042" "0.944" "1.213" "1.289" "1.249" "0.741" "3795.7" "3812.7" "3873.0" "4187.2" "3955.1" "3582.5" "4603.7" "4891.7" "4742.3" "2813.4" "" "" "" "" "" "" "" "" "" "" "3365.9" "3158.2" "3379.4" "3131.5" "3298.0" "3290.9" "3890.8" "4043.4" "4349.3" "2813.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.000" "False" "108.531" "32" "8" "25" "8" "328" "35.2" "8.48" "105.82" "8" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "RHOBTB2 GTPase cycle" "" "1" "0" "0.995" "0.997" "1.069" "1.051" "1.015" "1.085" "1.073" "1.034" "1.052" "2853.8" "2839.3" "2845.2" "3051.0" "2999.1" "2897.8" "3097.3" "3061.5" "2950.2" "3001.2" "" "" "" "" "" "" "" "" "" "" "2530.7" "2351.9" "2482.6" "2281.7" "2500.9" "2662.0" "2617.7" "2530.5" "2705.7" "3001.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "108.528" "24" "12" "18" "12" "737" "80.9" "5.83" "92.34" "12" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "" "3" "0" "1.030" "1.001" "1.048" "1.041" "1.034" "1.050" "1.022" "0.978" "0.598" "2060.5" "2123.0" "2063.5" "2158.9" "2144.7" "2130.3" "2163.0" "2106.0" "2015.8" "1233.0" "" "" "" "" "" "" "" "" "" "" "1827.2" "1758.6" "1800.5" "1614.6" "1788.4" "1956.9" "1828.1" "1740.7" "1848.8" "1233.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4862457629609710254" "False" "High" "IsMasterProtein" "Q5SW79" "Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1" "0.000" "False" "108.454" "16" "23" "28" "23" "1584" "175.2" "7.11" "91.55" "23" "" "cytosol;cytoskeleton;other cell component" "" "Pf00498, Pf15308" "9859" "ENSG00000143702; ENSG00000276725" "CEP170" "hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09" "" "Ciliary landscape" "1" "0" "1.001" "0.926" "0.941" "0.903" "0.877" "0.846" "0.863" "0.897" "1.171" "2193.7" "2194.9" "2030.3" "2064.5" "1980.6" "1922.9" "1855.3" "1893.0" "1967.1" "2567.9" "" "" "" "" "" "" "" "" "" "" "1945.3" "1818.2" "1771.5" "1544.0" "1651.5" "1766.4" "1568.0" "1564.7" "1804.1" "2567.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099504193891774007" "False" "High" "IsMasterProtein" "Q13557" "Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3" "0.000" "False" "108.255" "32" "14" "26" "11" "499" "56.3" "7.25" "97.87" "14" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "817" "ENSG00000145349" "CAMK2D" "A8MVS8; hsa:817; Q13557; Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9" "Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Signaling by BRAF and RAF1 fusions; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; ErbB signaling pathway" "33" "2" "0.991" "0.917" "1.033" "1.019" "1.091" "0.962" "0.927" "0.975" "1.449" "2236.2" "2216.7" "2050.7" "2309.5" "2278.0" "2439.9" "2150.9" "2074.0" "2180.8" "3241.1" "" "" "" "" "" "" "" "" "" "" "1983.0" "1836.2" "1789.3" "1727.2" "1899.5" "2241.3" "1817.8" "1714.3" "2000.1" "3241.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "107.988" "37" "17" "24" "14" "519" "58.4" "5.12" "97.48" "17" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "Golgi Associated Vesicle Biogenesis" "" "1" "2" "0.926" "0.952" "1.031" "0.981" "0.894" "1.227" "1.084" "1.092" "2.327" "1873.0" "1734.7" "1782.2" "1931.9" "1837.5" "1673.5" "2297.3" "2030.6" "2044.5" "4358.8" "" "" "" "" "" "" "" "" "" "" "1660.9" "1437.0" "1555.1" "1444.8" "1532.2" "1537.3" "1941.6" "1678.5" "1875.1" "4358.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "107.973" "43" "14" "37" "14" "297" "34.3" "9.72" "134.00" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.951" "1.000" "0.905" "1.003" "1.164" "0.913" "0.934" "0.936" "0.811" "4700.3" "4468.1" "4701.8" "4254.6" "4716.2" "5472.0" "4290.1" "4391.4" "4399.7" "3814.1" "" "" "" "" "" "" "" "" "" "" "4168.1" "3701.1" "4102.5" "3181.9" "3932.7" "5026.7" "3625.8" "3629.8" "4035.1" "3814.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "107.773" "44" "6" "24" "6" "192" "21.2" "5.22" "100.17" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "Release of apoptotic factors from the mitochondria; Pyroptosis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "48" "0" "1.019" "1.004" "1.043" "1.052" "1.030" "1.036" "1.042" "0.997" "0.815" "2851.9" "2906.8" "2863.2" "2974.7" "3001.1" "2938.1" "2954.0" "2971.2" "2844.4" "2324.3" "" "" "" "" "" "" "" "" "" "" "2529.0" "2407.8" "2498.3" "2224.7" "2502.5" "2699.0" "2496.6" "2455.9" "2608.7" "2324.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "107.755" "66" "9" "38" "9" "190" "20.1" "9.26" "148.51" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "0.944" "0.952" "1.028" "0.964" "0.961" "0.960" "0.992" "0.975" "0.485" "3062.6" "2892.5" "2914.9" "3146.9" "2951.2" "2942.7" "2939.0" "3038.8" "2984.8" "1485.4" "" "" "" "" "" "" "" "" "" "" "2715.9" "2396.0" "2543.4" "2353.5" "2460.9" "2703.2" "2483.9" "2511.8" "2737.4" "1485.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "107.698" "41" "17" "37" "17" "390" "43.3" "8.06" "126.57" "17" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "17" "0" "0.909" "0.961" "0.959" "0.950" "0.881" "0.935" "0.923" "0.905" "0.909" "5412.0" "4919.8" "5203.0" "5187.4" "5142.7" "4770.5" "5059.6" "4997.5" "4899.8" "4919.7" "" "" "" "" "" "" "" "" "" "" "4799.2" "4075.4" "4539.8" "3879.5" "4288.3" "4382.3" "4276.1" "4130.8" "4493.8" "4919.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "107.522" "30" "18" "31" "18" "558" "66.4" "8.84" "112.82" "18" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "mRNA Splicing - Major Pathway" "" "1" "0" "0.951" "0.969" "0.956" "0.944" "0.993" "0.913" "0.895" "0.941" "0.524" "3195.5" "3040.5" "3095.6" "3056.4" "3015.0" "3173.1" "2916.9" "2860.9" "3005.7" "1675.5" "" "" "" "" "" "" "" "" "" "" "2833.7" "2518.6" "2701.1" "2285.8" "2514.1" "2914.8" "2465.2" "2364.7" "2756.7" "1675.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3625950205882740020" "False" "High" "IsMasterProtein" "Q9NWQ8" "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 OS=Homo sapiens OX=9606 GN=PAG1 PE=1 SV=2" "0.000" "False" "107.480" "34" "11" "21" "11" "432" "47.0" "4.65" "93.62" "11" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15347" "55824" "ENSG00000076641" "PAG1" "A8K1A3; hsa:55824; Q2M1Z9; Q5BKU4; Q9NWQ8; Q9NYK0" "Phosphorylation of CD3 and TCR zeta chains; GAB1 signalosome" "" "2" "0" "1.022" "1.044" "0.982" "1.046" "1.082" "0.911" "0.997" "1.000" "0.443" "2837.3" "2900.2" "2961.1" "2787.5" "2967.3" "3069.0" "2583.8" "2829.4" "2837.4" "1256.8" "" "" "" "" "" "" "" "" "" "" "2516.1" "2402.4" "2583.7" "2084.7" "2474.3" "2819.2" "2183.7" "2338.7" "2602.3" "1256.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "107.447" "23" "7" "26" "7" "419" "49.5" "5.69" "110.33" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "HATs acetylate histones" "Ethanol effects on histone modifications" "2" "0" "1.073" "1.068" "1.101" "1.063" "1.056" "1.118" "1.131" "1.043" "1.173" "2780.3" "2983.4" "2969.1" "3059.9" "2954.1" "2937.1" "3108.1" "3143.7" "2899.4" "3260.0" "" "" "" "" "" "" "" "" "" "" "2465.5" "2471.3" "2590.7" "2288.4" "2463.3" "2698.1" "2626.9" "2598.5" "2659.2" "3260.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815926444524445653" "False" "High" "IsMasterProtein" "Q7Z406" "Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2" "0.000" "False" "107.266" "6" "14" "40" "2" "1995" "227.7" "5.60" "155.11" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "79784" "ENSG00000105357" "MYH14" "B0I1S2; C3TTN4; hsa:79784; Q5CZ75; Q6XYE4; Q76B62; Q7Z406; Q8WV23; Q96I22; Q9BT27; Q9BW35; Q9H882" "EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases activate PAKs" "" "6" "0" "0.923" "0.785" "1.080" "0.968" "1.060" "0.946" "1.088" "0.737" "0.607" "113.2" "104.5" "88.9" "122.3" "109.6" "120.0" "107.1" "123.2" "83.5" "68.8" "" "" "" "" "" "" "" "" "" "" "100.4" "86.6" "77.6" "91.5" "91.4" "110.2" "90.6" "101.8" "76.5" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "107.113" "29" "19" "30" "19" "677" "76.2" "7.03" "105.11" "19" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "DNA repair pathways, full network" "5" "0" "1.078" "0.970" "1.009" "0.993" "1.016" "0.958" "0.976" "0.933" "0.720" "3086.8" "3328.6" "2993.4" "3115.8" "3064.9" "3135.5" "2956.7" "3011.8" "2878.5" "2223.7" "" "" "" "" "" "" "" "" "" "" "2737.3" "2757.3" "2611.9" "2330.2" "2555.7" "2880.3" "2498.9" "2489.5" "2640.0" "2223.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "107.044" "47" "9" "22" "9" "212" "24.7" "8.19" "97.43" "9" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "1.007" "1.044" "1.036" "1.045" "1.053" "1.140" "1.173" "1.125" "1.144" "2956.4" "2977.5" "3085.7" "3062.3" "3089.9" "3111.8" "3370.4" "3467.8" "3326.2" "3383.1" "" "" "" "" "" "" "" "" "" "" "2621.7" "2466.4" "2692.4" "2290.2" "2576.5" "2858.5" "2848.6" "2866.4" "3050.6" "3383.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "107.027" "55" "8" "31" "8" "194" "21.4" "5.66" "136.03" "8" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "Purine catabolism; Ribavirin ADME" "" "2" "0" "1.032" "1.058" "1.022" "1.103" "1.119" "1.105" "1.079" "1.118" "0.576" "1915.0" "1977.2" "2025.6" "1956.7" "2112.0" "2143.5" "2116.5" "2066.9" "2141.4" "1102.2" "" "" "" "" "" "" "" "" "" "" "1698.2" "1637.9" "1767.4" "1463.3" "1761.2" "1969.1" "1788.8" "1708.4" "1963.9" "1102.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "106.950" "35" "17" "27" "17" "707" "78.5" "4.87" "104.80" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "1.012" "0.969" "1.020" "0.991" "0.913" "1.000" "1.014" "1.031" "0.808" "1951.1" "1975.5" "1890.1" "1990.2" "1934.3" "1781.0" "1951.8" "1978.1" "2011.7" "1576.7" "" "" "" "" "" "" "" "" "" "" "1730.2" "1636.4" "1649.2" "1488.4" "1613.0" "1636.1" "1649.6" "1635.0" "1845.0" "1576.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "High" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.000" "False" "106.712" "44" "12" "28" "12" "314" "36.0" "4.61" "121.16" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "1.005" "1.002" "1.040" "0.986" "1.027" "1.039" "0.990" "0.976" "1.118" "3660.1" "3677.1" "3667.8" "3805.9" "3609.3" "3758.7" "3804.1" "3624.5" "3571.3" "4090.3" "" "" "" "" "" "" "" "" "" "" "3245.7" "3045.9" "3200.3" "2846.3" "3009.7" "3452.7" "3215.1" "2995.9" "3275.4" "4090.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "106.671" "23" "19" "29" "19" "777" "86.1" "6.16" "104.46" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "16" "0" "0.993" "1.020" "0.943" "0.958" "1.004" "0.920" "0.951" "0.986" "1.493" "3664.1" "3639.2" "3736.6" "3456.2" "3511.8" "3679.7" "3369.6" "3482.9" "3613.7" "5470.4" "" "" "" "" "" "" "" "" "" "" "3249.2" "3014.5" "3260.4" "2584.8" "2928.4" "3380.2" "2847.8" "2878.8" "3314.2" "5470.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "106.646" "48" "18" "43" "14" "341" "39.8" "6.89" "152.86" "18" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "6" "4" "0.991" "0.965" "1.004" "1.006" "0.992" "0.998" "1.017" "0.937" "0.483" "3987.8" "3950.5" "3848.4" "4004.8" "4013.7" "3956.6" "3979.3" "4056.0" "3738.5" "1927.6" "" "" "" "" "" "" "" "" "" "" "3536.3" "3272.4" "3357.9" "2995.0" "3346.8" "3634.6" "3363.2" "3352.6" "3428.7" "1927.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "106.588" "33" "16" "35" "16" "582" "64.8" "5.29" "117.57" "16" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "0.984" "0.984" "0.988" "0.979" "0.953" "0.993" "1.012" "0.988" "0.703" "2385.4" "2347.3" "2346.4" "2355.8" "2335.1" "2274.0" "2367.7" "2414.7" "2356.1" "1678.1" "" "" "" "" "" "" "" "" "" "" "2115.3" "1944.4" "2047.3" "1761.8" "1947.2" "2089.0" "2001.1" "1995.9" "2160.8" "1678.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "106.527" "18" "22" "25" "22" "1401" "157.1" "6.61" "88.47" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "Condensation of Prometaphase Chromosomes" "" "1" "0" "0.998" "0.864" "1.130" "0.947" "0.865" "1.014" "0.536" "0.909" "7.374" "784.0" "782.3" "677.1" "886.1" "742.4" "678.2" "794.8" "420.0" "712.3" "5781.0" "" "" "" "" "" "" "" "" "" "" "695.2" "648.0" "590.8" "662.7" "619.0" "623.0" "671.7" "347.2" "653.3" "5781.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "106.451" "10" "26" "27" "26" "2671" "292.5" "7.43" "96.04" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "" "1" "0" "0.977" "0.844" "1.130" "0.939" "0.904" "1.012" "0.331" "0.964" "12.393" "727.2" "710.4" "613.9" "821.6" "682.6" "657.5" "736.2" "240.6" "700.9" "9012.7" "" "" "" "" "" "" "" "" "" "" "644.9" "588.5" "535.6" "614.4" "569.2" "604.0" "622.2" "198.9" "642.8" "9012.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "106.432" "34" "12" "28" "12" "433" "48.3" "7.47" "103.27" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "33" "0" "0.989" "1.045" "1.013" "1.005" "1.035" "1.090" "1.100" "1.084" "0.591" "4701.1" "4649.1" "4912.8" "4762.1" "4725.3" "4865.0" "5126.3" "5170.9" "5093.9" "2778.1" "" "" "" "" "" "" "" "" "" "" "4168.9" "3851.1" "4286.6" "3561.4" "3940.2" "4469.0" "4332.6" "4274.1" "4671.8" "2778.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "106.380" "16" "15" "22" "15" "953" "106.3" "8.32" "91.83" "15" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "0.963" "0.892" "0.922" "0.865" "0.850" "0.789" "0.810" "0.847" "0.658" "2753.1" "2651.6" "2454.6" "2539.1" "2381.1" "2341.5" "2172.7" "2230.6" "2332.8" "1810.9" "" "" "" "" "" "" "" "" "" "" "2441.4" "2196.4" "2141.7" "1898.9" "1985.5" "2150.9" "1836.2" "1843.7" "2139.5" "1810.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6134268530089920080" "False" "High" "IsMasterProtein" "P09668" "Pro-cathepsin H OS=Homo sapiens OX=9606 GN=CTSH PE=1 SV=4" "0.000" "False" "106.367" "33" "10" "32" "10" "335" "37.4" "8.07" "126.35" "10" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1512" "ENSG00000103811" "CTSH" "B2RBK0; hsa:1512; P09668; Q96NY6; Q9BUM7" "MHC class II antigen presentation; Neutrophil degranulation; Surfactant metabolism" "" "3" "0" "1.013" "1.062" "0.968" "1.048" "1.110" "0.978" "1.021" "1.027" "0.558" "3160.4" "3200.0" "3357.5" "3058.7" "3311.1" "3507.7" "3090.9" "3228.1" "3246.0" "1763.7" "" "" "" "" "" "" "" "" "" "" "2802.6" "2650.7" "2929.6" "2287.5" "2761.0" "3222.2" "2612.3" "2668.2" "2977.0" "1763.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "106.250" "49" "13" "28" "13" "305" "33.7" "7.33" "102.25" "13" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Recycling of eIF2:GDP" "Translation factors" "2" "0" "1.024" "1.011" "1.057" "1.061" "1.048" "1.065" "1.063" "0.961" "0.585" "4081.4" "4179.9" "4125.1" "4314.0" "4331.8" "4276.3" "4346.7" "4338.4" "3922.7" "2389.7" "" "" "" "" "" "" "" "" "" "" "3619.3" "3462.4" "3599.4" "3226.3" "3612.1" "3928.2" "3673.6" "3586.0" "3597.7" "2389.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "106.225" "45" "8" "51" "8" "227" "26.3" "6.34" "222.77" "8" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "11" "0" "0.995" "0.972" "0.858" "0.966" "0.936" "0.994" "1.049" "1.024" "0.681" "6121.3" "6087.7" "5952.3" "5253.8" "5911.0" "5729.3" "6083.2" "6422.5" "6267.1" "4169.1" "" "" "" "" "" "" "" "" "" "" "5428.2" "5042.8" "5193.7" "3929.1" "4929.0" "5263.0" "5141.3" "5308.6" "5747.8" "4169.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "106.158" "38" "17" "29" "17" "593" "66.5" "8.09" "96.21" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Mitochondrial tRNA aminoacylation" "Amino acid metabolism" "2" "0" "1.025" "1.001" "1.055" "1.079" "1.033" "1.023" "1.055" "0.981" "0.497" "1856.4" "1903.0" "1858.7" "1959.3" "2003.5" "1918.5" "1899.1" "1958.4" "1821.4" "922.4" "" "" "" "" "" "" "" "" "" "" "1646.3" "1576.4" "1621.8" "1465.3" "1670.7" "1762.4" "1605.1" "1618.8" "1670.5" "922.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "105.919" "37" "12" "24" "8" "375" "41.6" "7.74" "89.50" "12" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "FGFR2 alternative splicing" "" "1" "0" "1.055" "1.114" "1.081" "1.075" "1.048" "1.097" "1.161" "1.220" "0.771" "1739.1" "1835.5" "1936.6" "1880.8" "1868.9" "1822.4" "1907.2" "2018.5" "2121.3" "1341.3" "" "" "" "" "" "" "" "" "" "" "1542.2" "1520.5" "1689.8" "1406.6" "1558.4" "1674.1" "1611.9" "1668.4" "1945.5" "1341.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254459010250463691" "False" "High" "IsMasterProtein" "Cont_Q3ZBD7" "Glucose-6-phosphate isomerase OS=Bos taurus OX=9913 GN=GPI PE=2 SV=4" "0.000" "True" "105.903" "19" "9" "53" "2" "557" "62.8" "7.71" "220.56" "9" "other metabolic processes;signal transduction" "non-structural extracellular;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "104995211; 109572099; 280808" "ENSBTAG00000006396" "GPI" "A0A6B0R509; A0A6P3HXC3; A0A6P5DB13; biu:109572099; bta:280808; F1MD19; O46595; Q3ZBD7" "TP53 Regulates Metabolic Genes; Neutrophil degranulation; Gluconeogenesis; Glycolysis" "Glycolysis and gluconeogenesis; Cori cycle" "6" "0" "0.881" "0.876" "1.009" "0.885" "1.108" "0.911" "1.068" "0.920" "0.490" "1535.5" "1352.5" "1345.7" "1549.4" "1359.1" "1700.8" "1398.2" "1639.3" "1412.8" "752.2" "" "" "" "" "" "" "" "" "" "" "1361.6" "1120.3" "1174.2" "1158.7" "1133.3" "1562.4" "1181.7" "1355.0" "1295.7" "752.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "105.852" "17" "19" "22" "19" "1401" "151.6" "5.86" "75.14" "19" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.090" "1.035" "1.037" "1.029" "1.037" "0.982" "0.918" "0.918" "1.531" "1534.8" "1672.5" "1588.5" "1591.4" "1579.7" "1591.0" "1507.0" "1409.2" "1408.5" "2349.3" "" "" "" "" "" "" "" "" "" "" "1361.0" "1385.5" "1386.0" "1190.1" "1317.3" "1461.5" "1273.7" "1164.8" "1291.8" "2349.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "105.846" "36" "13" "21" "13" "485" "53.3" "7.34" "100.58" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "" "17q12 copy number variation syndrome" "1" "0" "0.992" "0.995" "1.074" "1.076" "1.053" "1.146" "1.114" "1.078" "0.783" "1931.5" "1915.3" "1921.7" "2074.4" "2078.7" "2034.3" "2213.2" "2152.4" "2081.7" "1511.6" "" "" "" "" "" "" "" "" "" "" "1712.8" "1586.6" "1676.8" "1551.4" "1733.4" "1868.8" "1870.5" "1779.1" "1909.2" "1511.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "105.511" "56" "12" "69" "12" "217" "25.2" "6.32" "224.31" "12" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "73" "0" "0.931" "0.937" "0.942" "0.932" "0.979" "0.871" "0.925" "0.914" "0.627" "7601.4" "7074.8" "7123.2" "7162.9" "7081.6" "7445.6" "6621.0" "7028.4" "6946.1" "4767.3" "" "" "" "" "" "" "" "" "" "" "6740.8" "5860.4" "6215.4" "5356.9" "5905.1" "6839.6" "5595.8" "5809.5" "6370.5" "4767.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "High" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.000" "False" "105.495" "40" "13" "22" "12" "391" "45.1" "7.74" "93.80" "13" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "22" "1" "0.973" "0.964" "1.004" "1.008" "0.985" "0.939" "0.960" "0.899" "1.591" "2398.4" "2334.3" "2312.9" "2408.6" "2416.5" "2363.4" "2252.7" "2303.5" "2156.3" "3815.5" "" "" "" "" "" "" "" "" "" "" "2126.8" "1933.6" "2018.1" "1801.3" "2015.0" "2171.1" "1903.9" "1904.0" "1977.6" "3815.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "105.473" "22" "25" "30" "25" "1056" "119.1" "5.64" "105.98" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "" "3" "0" "1.044" "0.941" "1.070" "0.945" "0.951" "1.050" "0.361" "1.019" "11.605" "1698.4" "1772.7" "1598.3" "1817.2" "1605.5" "1614.4" "1783.4" "612.5" "1729.8" "19710.4" "" "" "" "" "" "" "" "" "" "" "1506.1" "1468.4" "1394.6" "1359.0" "1338.8" "1483.0" "1507.2" "506.3" "1586.5" "19710.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "105.322" "17" "20" "37" "19" "1313" "140.2" "9.57" "135.45" "20" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "2" "0" "0.940" "0.925" "0.902" "0.862" "0.884" "0.908" "0.920" "0.950" "0.862" "3783.0" "3555.2" "3500.5" "3411.7" "3261.7" "3344.3" "3433.4" "3480.2" "3595.0" "3260.9" "" "" "" "" "" "" "" "" "" "" "3354.7" "2945.0" "3054.4" "2551.5" "2719.8" "3072.1" "2901.8" "2876.6" "3297.1" "3260.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "105.051" "39" "19" "28" "19" "503" "57.6" "7.14" "104.03" "19" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "0.989" "0.941" "0.955" "0.908" "0.934" "0.958" "0.903" "0.856" "0.909" "3135.1" "3101.9" "2949.5" "2993.7" "2845.5" "2928.2" "3004.7" "2831.7" "2683.0" "2850.6" "" "" "" "" "" "" "" "" "" "" "2780.1" "2569.5" "2573.6" "2238.9" "2372.8" "2689.9" "2539.4" "2340.6" "2460.7" "2850.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "104.909" "78" "14" "46" "5" "205" "22.7" "6.21" "160.23" "14" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "8" "0.976" "0.975" "0.956" "0.962" "1.000" "0.933" "0.944" "0.859" "0.458" "7226.9" "7051.0" "7044.6" "6911.6" "6951.7" "7227.4" "6743.0" "6822.7" "6205.1" "3306.6" "" "" "" "" "" "" "" "" "" "" "6408.7" "5840.7" "6146.8" "5168.9" "5796.8" "6639.2" "5698.9" "5639.4" "5690.9" "3306.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "104.901" "44" "12" "28" "12" "312" "35.1" "6.13" "113.74" "12" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "" "2" "0" "1.040" "1.001" "1.033" "0.973" "0.974" "0.968" "0.992" "0.941" "0.558" "2866.3" "2982.3" "2867.8" "2962.2" "2789.2" "2791.3" "2775.0" "2844.3" "2696.7" "1600.4" "" "" "" "" "" "" "" "" "" "" "2541.8" "2470.4" "2502.3" "2215.3" "2325.8" "2564.1" "2345.3" "2351.0" "2473.3" "1600.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "104.841" "32" "11" "55" "10" "332" "36.2" "8.21" "205.23" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "" "Pre-implantation embryo; mRNA processing" "2" "0" "0.986" "0.949" "0.955" "0.946" "0.912" "0.895" "0.947" "0.946" "0.498" "7649.3" "7544.8" "7255.4" "7304.9" "7234.2" "6975.4" "6846.7" "7246.2" "7239.0" "3808.0" "" "" "" "" "" "" "" "" "" "" "6783.3" "6249.7" "6330.7" "5463.1" "6032.4" "6407.7" "5786.5" "5989.5" "6639.2" "3808.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "104.786" "30" "18" "23" "18" "708" "80.5" "5.90" "91.83" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "31" "0" "0.981" "0.973" "1.002" "1.029" "0.991" "1.139" "0.942" "0.971" "1.097" "2529.1" "2481.6" "2461.1" "2533.1" "2603.4" "2505.6" "2879.8" "2381.4" "2456.0" "2775.3" "" "" "" "" "" "" "" "" "" "" "2242.8" "2055.7" "2147.4" "1894.4" "2170.9" "2301.7" "2433.9" "1968.4" "2252.4" "2775.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "104.774" "22" "19" "21" "19" "1046" "116.9" "6.70" "82.98" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "8" "0" "1.015" "1.030" "1.073" "1.070" "1.058" "1.208" "1.104" "1.143" "3.323" "1507.7" "1530.8" "1553.4" "1617.1" "1613.8" "1594.9" "1820.7" "1665.2" "1723.5" "5009.9" "" "" "" "" "" "" "" "" "" "" "1337.0" "1268.0" "1355.4" "1209.4" "1345.7" "1465.1" "1538.8" "1376.4" "1580.7" "5009.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "104.565" "31" "11" "34" "11" "369" "41.3" "5.27" "119.62" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.912" "0.964" "0.868" "0.856" "0.843" "1.041" "0.923" "0.994" "2.706" "4747.4" "4330.2" "4577.7" "4121.4" "4065.9" "4002.8" "4943.7" "4383.7" "4717.6" "12844.1" "" "" "" "" "" "" "" "" "" "" "4209.9" "3586.9" "3994.2" "3082.2" "3390.4" "3677.0" "4178.2" "3623.4" "4326.7" "12844.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "104.475" "26" "20" "25" "20" "910" "101.9" "7.17" "92.68" "20" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "Signaling by BRAF and RAF1 fusions" "VEGFA-VEGFR2 signaling" "2" "0" "1.020" "0.888" "1.059" "0.945" "0.901" "1.066" "0.446" "0.937" "9.605" "1223.5" "1247.7" "1085.9" "1295.7" "1156.0" "1102.5" "1303.7" "545.1" "1146.8" "11751.5" "" "" "" "" "" "" "" "" "" "" "1085.0" "1033.5" "947.5" "969.0" "964.0" "1012.8" "1101.8" "450.6" "1051.8" "11751.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "104.474" "22" "19" "24" "19" "923" "102.8" "5.22" "90.24" "19" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "Regulation of HSF1-mediated heat shock response" "TAR syndrome" "2" "0" "0.956" "0.966" "1.025" "0.998" "0.953" "0.982" "0.517" "0.973" "9.410" "1267.9" "1212.2" "1224.7" "1299.6" "1265.4" "1207.8" "1244.9" "655.9" "1233.1" "11931.4" "" "" "" "" "" "" "" "" "" "" "1124.4" "1004.1" "1068.6" "972.0" "1055.2" "1109.5" "1052.1" "542.1" "1130.9" "11931.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "104.303" "34" "17" "29" "17" "568" "65.5" "6.19" "103.16" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.996" "1.034" "1.041" "1.035" "1.003" "0.963" "0.984" "0.992" "0.670" "2547.5" "2538.5" "2633.3" "2651.0" "2637.5" "2554.3" "2452.6" "2505.5" "2526.8" "1705.9" "" "" "" "" "" "" "" "" "" "" "2259.0" "2102.8" "2297.7" "1982.6" "2199.3" "2346.4" "2072.9" "2071.0" "2317.4" "1705.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5279606303405418158" "False" "High" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "0.000" "False" "104.192" "25" "21" "28" "19" "898" "105.3" "7.30" "106.43" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "MAPK signaling pathway" "4" "1" "0.992" "0.933" "0.870" "0.762" "0.800" "0.734" "0.755" "0.858" "2.146" "2108.4" "2092.3" "1967.8" "1835.3" "1607.2" "1686.8" "1547.9" "1590.8" "1807.9" "4524.4" "" "" "" "" "" "" "" "" "" "" "1869.6" "1733.1" "1717.0" "1372.5" "1340.2" "1549.5" "1308.2" "1314.9" "1658.1" "4524.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "104.172" "51" "10" "18" "10" "259" "28.5" "6.24" "74.67" "10" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "1.048" "0.948" "1.058" "1.019" "1.057" "1.040" "1.042" "0.912" "0.659" "1542.3" "1615.8" "1461.5" "1631.5" "1572.2" "1629.8" "1604.4" "1607.2" "1406.3" "1016.0" "" "" "" "" "" "" "" "" "" "" "1367.7" "1338.4" "1275.2" "1220.2" "1311.0" "1497.2" "1356.0" "1328.4" "1289.7" "1016.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "104.064" "33" "13" "31" "7" "443" "49.3" "5.69" "107.58" "13" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "Apoptotic cleavage of cellular proteins" "" "2" "6" "0.969" "0.978" "0.910" "0.964" "1.013" "0.993" "1.072" "1.078" "0.862" "3678.0" "3564.6" "3595.8" "3346.7" "3544.6" "3726.6" "3653.9" "3942.3" "3965.9" "3172.2" "" "" "" "" "" "" "" "" "" "" "3261.6" "2952.7" "3137.5" "2502.9" "2955.7" "3423.3" "3088.2" "3258.6" "3637.3" "3172.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4348390061636338319" "False" "High" "IsMasterProtein" "Q9HAW4" "Claspin OS=Homo sapiens OX=9606 GN=CLSPN PE=1 SV=3" "0.000" "False" "104.043" "16" "17" "20" "17" "1339" "151.0" "4.82" "74.75" "17" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "63967" "ENSG00000092853" "CLSPN" "A6NFL4; hsa:63967; Q1RMC6; Q2KHM3; Q5VYG0; Q6P6H5; Q8IWI1; Q9HAW4" "Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Ub-specific processing proteases; Apoptotic cleavage of cellular proteins" "" "4" "0" "1.004" "0.978" "0.952" "0.969" "0.926" "0.968" "0.964" "1.022" "0.929" "1905.1" "1913.1" "1863.2" "1813.7" "1845.6" "1763.5" "1843.2" "1836.0" "1947.0" "1769.5" "" "" "" "" "" "" "" "" "" "" "1689.4" "1584.7" "1625.7" "1356.4" "1539.0" "1620.0" "1557.8" "1517.6" "1785.6" "1769.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "103.769" "50" "13" "33" "13" "307" "34.5" "6.70" "124.55" "13" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "22q11.2 copy number variation syndrome" "5" "0" "1.018" "1.013" "0.967" "0.991" "0.962" "0.980" "1.005" "1.032" "0.620" "3589.9" "3655.4" "3636.7" "3471.7" "3555.9" "3452.8" "3518.6" "3606.8" "3704.8" "2226.0" "" "" "" "" "" "" "" "" "" "" "3183.4" "3028.0" "3173.2" "2596.3" "2965.1" "3171.8" "2973.8" "2981.3" "3397.8" "2226.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "103.663" "71" "15" "66" "15" "201" "23.0" "5.21" "228.21" "15" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "RAC3 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RHOH GTPase cycle" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "9" "0" "0.970" "1.049" "0.931" "1.017" "0.982" "0.965" "1.003" "1.035" "0.816" "7936.6" "7700.9" "8328.8" "7385.8" "8068.3" "7796.4" "7656.6" "7960.4" "8211.9" "6478.6" "" "" "" "" "" "" "" "" "" "" "7038.0" "6379.1" "7267.3" "5523.6" "6727.8" "7161.9" "6471.0" "6579.9" "7531.4" "6478.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "103.663" "32" "14" "26" "14" "562" "58.2" "8.63" "106.42" "14" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "0.976" "1.025" "0.963" "0.933" "0.894" "0.826" "0.928" "1.017" "0.717" "1981.3" "1934.3" "2030.3" "1907.2" "1848.2" "1771.4" "1636.8" "1839.5" "2014.7" "1420.3" "" "" "" "" "" "" "" "" "" "" "1756.9" "1602.3" "1771.6" "1426.3" "1541.1" "1627.3" "1383.4" "1520.4" "1847.7" "1420.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819475231177228561" "False" "High" "IsMasterProtein" "O94966" "Ubiquitin carboxyl-terminal hydrolase 19 OS=Homo sapiens OX=9606 GN=USP19 PE=1 SV=2" "0.000" "False" "103.648" "20" "19" "22" "19" "1318" "145.6" "6.28" "84.78" "19" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf01753, Pf04969, Pf16602" "10869" "ENSG00000172046" "USP19" "A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8; hsa:10869; O94966; Q3KQW4; Q641Q9; Q6NZY8; Q86XV9" "Ub-specific processing proteases" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "2" "0" "1.107" "1.046" "1.141" "1.059" "1.004" "1.026" "0.978" "0.997" "1.149" "1028.0" "1138.4" "1075.1" "1172.5" "1088.6" "1031.8" "1054.7" "1005.4" "1025.2" "1181.5" "" "" "" "" "" "" "" "" "" "" "911.6" "943.0" "938.1" "876.9" "907.8" "947.8" "891.4" "831.0" "940.2" "1181.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "103.234" "40" "12" "23" "12" "396" "42.4" "6.46" "97.11" "12" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "1.019" "1.026" "1.097" "1.085" "1.104" "1.165" "1.175" "1.048" "0.666" "1797.1" "1831.5" "1843.6" "1970.9" "1950.5" "1983.1" "2093.3" "2111.1" "1882.7" "1196.6" "" "" "" "" "" "" "" "" "" "" "1593.6" "1517.1" "1608.7" "1474.0" "1626.4" "1821.7" "1769.2" "1745.0" "1726.7" "1196.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "102.945" "28" "15" "23" "15" "652" "70.7" "7.90" "88.14" "15" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis" "" "4" "0" "0.994" "1.068" "1.028" "1.020" "1.056" "1.009" "1.016" "0.977" "0.604" "3153.9" "3134.7" "3369.0" "3241.3" "3217.8" "3330.4" "3183.4" "3204.0" "3081.8" "1905.4" "" "" "" "" "" "" "" "" "" "" "2796.8" "2596.6" "2939.7" "2424.0" "2683.2" "3059.3" "2690.5" "2648.4" "2826.5" "1905.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "102.868" "61" "12" "50" "12" "169" "19.4" "8.81" "159.97" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "" "Metapathway biotransformation Phase I and II" "1" "0" "0.999" "1.025" "1.004" "0.981" "1.029" "1.016" "1.042" "1.000" "0.492" "5106.9" "5099.3" "5234.5" "5129.8" "5008.3" "5256.0" "5188.0" "5323.4" "5107.4" "2513.4" "" "" "" "" "" "" "" "" "" "" "4528.7" "4224.0" "4567.4" "3836.4" "4176.3" "4828.3" "4384.7" "4400.1" "4684.2" "2513.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7578805457300167027" "False" "High" "IsMasterProtein" "Q6WKZ4" "Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3" "0.000" "False" "102.859" "16" "18" "22" "18" "1283" "137.1" "5.43" "86.34" "18" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf09457" "80223" "ENSG00000156675" "RAB11FIP1" "hsa:80223; J3KNP0; Q307T1; Q6AZK4; Q6WKZ2; Q6WKZ4; Q6WKZ6; Q86YV4; Q8TDL1; Q9H642" "" "" "0" "0" "1.011" "0.982" "0.911" "0.918" "0.899" "0.905" "0.896" "0.979" "0.976" "1620.4" "1638.9" "1592.0" "1476.5" "1486.8" "1456.1" "1465.7" "1452.0" "1586.6" "1581.7" "" "" "" "" "" "" "" "" "" "" "1437.0" "1357.6" "1389.1" "1104.2" "1239.8" "1337.6" "1238.8" "1200.2" "1455.1" "1581.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "102.705" "18" "13" "27" "13" "783" "87.3" "9.28" "101.45" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "4" "0" "1.018" "0.982" "0.985" "0.952" "0.942" "0.942" "0.967" "0.991" "0.936" "4019.1" "4090.1" "3946.0" "3957.5" "3826.4" "3787.2" "3784.4" "3887.6" "3982.8" "3760.8" "" "" "" "" "" "" "" "" "" "" "3564.0" "3388.0" "3443.0" "2959.7" "3190.7" "3479.0" "3198.4" "3213.4" "3652.8" "3760.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "102.699" "31" "10" "22" "10" "358" "40.5" "6.18" "92.83" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "2" "0" "0.987" "1.041" "1.021" "1.056" "1.141" "1.096" "1.155" "1.121" "0.551" "3164.3" "3124.3" "3292.5" "3231.9" "3340.6" "3609.7" "3467.1" "3655.6" "3545.8" "1743.6" "" "" "" "" "" "" "" "" "" "" "2806.0" "2588.0" "2872.9" "2417.0" "2785.6" "3315.9" "2930.3" "3021.6" "3252.0" "1743.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "102.478" "21" "21" "29" "21" "1102" "128.2" "5.55" "104.85" "21" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Regulation of TP53 Degradation; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "10" "0" "1.214" "0.907" "1.312" "1.132" "0.941" "1.113" "0.597" "0.956" "7.845" "1171.6" "1422.8" "1062.4" "1536.7" "1326.2" "1102.2" "1304.2" "699.9" "1119.5" "9191.4" "" "" "" "" "" "" "" "" "" "" "1038.9" "1178.6" "927.0" "1149.3" "1105.9" "1012.5" "1102.3" "578.5" "1026.7" "9191.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "High" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.000" "False" "102.449" "49" "8" "22" "8" "273" "29.3" "8.18" "102.06" "8" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "Ion transport by P-type ATPases" "" "1" "0" "1.013" "1.083" "1.102" "1.075" "1.051" "1.049" "1.045" "1.031" "0.595" "2416.8" "2447.5" "2616.3" "2663.7" "2598.6" "2539.1" "2534.7" "2526.2" "2492.1" "1437.1" "" "" "" "" "" "" "" "" "" "" "2143.2" "2027.4" "2282.8" "1992.1" "2166.9" "2332.4" "2142.2" "2088.1" "2285.6" "1437.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "102.377" "28" "10" "27" "10" "386" "42.9" "5.30" "103.45" "10" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Branched-chain amino acid catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "4" "0" "1.029" "1.068" "1.002" "1.076" "1.118" "1.052" "0.994" "0.919" "0.499" "2622.0" "2696.8" "2799.8" "2627.2" "2821.1" "2932.4" "2758.3" "2606.2" "2410.1" "1308.8" "" "" "" "" "" "" "" "" "" "" "2325.2" "2233.9" "2442.9" "1964.8" "2352.4" "2693.7" "2331.2" "2154.2" "2210.4" "1308.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5376062369618088086" "False" "High" "IsMasterProtein" "P01834" "Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2" "0.000" "False" "102.330" "79" "5" "17" "5" "107" "11.8" "6.52" "98.62" "5" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07654" "" "" "IGKC" "A0A075B6H6; A0A087X130; P01834" "Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "" "19" "0" "1.038" "1.119" "0.966" "1.113" "1.196" "0.932" "0.973" "1.051" "1.497" "2014.4" "2091.1" "2254.8" "1945.5" "2241.1" "2409.8" "1877.7" "1960.7" "2118.0" "3016.2" "" "" "" "" "" "" "" "" "" "" "1786.3" "1732.2" "1967.4" "1455.0" "1868.8" "2213.7" "1586.9" "1620.7" "1942.5" "3016.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040349963704556613" "False" "High" "IsMasterProtein" "P30154" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3" "0.000" "False" "102.308" "30" "16" "28" "9" "601" "66.2" "4.94" "98.53" "16" "other biological processes" "other membranes;other cell component" "enzyme regulator activity" "Pf02985, Pf13646" "5519" "ENSG00000137713" "PPP2R1B" "A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; hsa:5519; O75620; P30154; Q8NHV8" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DARPP-32 events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "40" "0" "0.973" "0.882" "1.029" "0.909" "0.930" "0.955" "0.622" "0.940" "6.521" "891.8" "867.3" "786.6" "917.5" "810.4" "829.4" "852.0" "554.5" "838.1" "5815.1" "" "" "" "" "" "" "" "" "" "" "790.8" "718.4" "686.3" "686.1" "675.8" "761.9" "720.1" "458.4" "768.7" "5815.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "102.306" "27" "16" "34" "16" "608" "65.8" "6.73" "124.00" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Estrogen-dependent gene expression; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "15" "0" "1.095" "1.099" "1.121" "1.154" "1.085" "1.080" "1.109" "1.026" "0.537" "3441.5" "3769.3" "3781.0" "3857.2" "3971.2" "3733.7" "3717.1" "3817.2" "3531.9" "1847.2" "" "" "" "" "" "" "" "" "" "" "3051.9" "3122.3" "3299.1" "2884.7" "3311.5" "3429.8" "3141.5" "3155.2" "3239.3" "1847.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "102.190" "26" "9" "29" "9" "429" "47.4" "5.60" "96.26" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; HATs acetylate histones; DNA Damage Recognition in GG-NER" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "10" "0" "1.000" "0.946" "0.972" "0.965" "1.015" "1.050" "1.001" "0.949" "1.056" "4061.0" "4061.3" "3841.9" "3948.7" "3918.0" "4121.7" "4263.5" "4063.2" "3855.2" "4289.2" "" "" "" "" "" "" "" "" "" "" "3601.2" "3364.2" "3352.2" "2953.1" "3267.1" "3786.2" "3603.3" "3358.5" "3535.8" "4289.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "102.152" "35" "10" "66" "7" "251" "28.8" "4.06" "240.02" "10" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "1.012" "1.061" "0.985" "1.033" "0.983" "0.926" "0.933" "0.999" "0.659" "5085.9" "5148.6" "5396.1" "5010.4" "5255.2" "4998.9" "4707.4" "4745.4" "5080.3" "3351.1" "" "" "" "" "" "" "" "" "" "" "4510.1" "4264.9" "4708.3" "3747.1" "4382.1" "4592.0" "3978.5" "3922.4" "4659.4" "3351.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "102.115" "59" "14" "49" "13" "216" "23.7" "9.41" "146.16" "14" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "4" "1" "0.963" "1.048" "0.962" "0.970" "0.989" "1.055" "1.052" "1.132" "1.111" "5682.7" "5473.9" "5956.8" "5465.8" "5513.0" "5619.0" "5997.5" "5979.1" "6435.5" "6315.0" "" "" "" "" "" "" "" "" "" "" "5039.3" "4534.3" "5197.6" "4087.7" "4597.1" "5161.6" "5068.8" "4942.2" "5902.3" "6315.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "102.036" "46" "15" "21" "15" "361" "39.3" "7.18" "84.28" "15" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "1.016" "1.016" "1.060" "1.031" "0.990" "1.043" "1.036" "1.013" "0.514" "1692.4" "1719.4" "1720.0" "1794.3" "1744.9" "1674.8" "1765.8" "1752.8" "1714.5" "869.9" "" "" "" "" "" "" "" "" "" "" "1500.8" "1424.3" "1500.8" "1341.9" "1455.0" "1538.5" "1492.4" "1448.8" "1572.4" "869.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1756895692335459560" "False" "High" "IsMasterProtein" "O95865" "Putative hydrolase DDAH2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1" "0.000" "False" "101.941" "54" "12" "20" "12" "285" "29.6" "6.01" "83.96" "12" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "" "23564" "ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076" "DDAH2" "A2BEZ7; hsa:23564; O95865" "" "Nitric oxide metabolism in cystic fibrosis" "1" "0" "1.019" "0.979" "1.016" "1.035" "1.049" "1.082" "1.084" "1.061" "0.509" "1466.9" "1495.1" "1436.6" "1490.6" "1517.8" "1538.5" "1587.6" "1590.5" "1556.7" "746.0" "" "" "" "" "" "" "" "" "" "" "1300.8" "1238.5" "1253.5" "1114.8" "1265.7" "1413.2" "1341.8" "1314.7" "1427.7" "746.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562653879591220854" "False" "High" "IsMasterProtein" "P09488" "Glutathione S-transferase Mu 1 OS=Homo sapiens OX=9606 GN=GSTM1 PE=1 SV=3" "0.000" "False" "101.926" "67" "15" "40" "5" "218" "25.7" "6.70" "137.58" "15" "other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00043, Pf02798" "2944" "ENSG00000134184" "GSTM1" "hsa:2944; P09488; Q5GHG0; Q6FH88; Q8TC98; Q9UC96" "Paracetamol ADME; Glutathione conjugation; Azathioprine ADME" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; Benzene metabolism; Estrogen metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "10" "4" "1.027" "1.063" "1.021" "1.061" "1.043" "1.094" "1.098" "1.075" "0.745" "4081.8" "4193.7" "4339.2" "4166.8" "4329.5" "4258.6" "4467.5" "4480.7" "4386.8" "3040.6" "" "" "" "" "" "" "" "" "" "" "3619.6" "3473.8" "3786.1" "3116.2" "3610.2" "3912.0" "3775.7" "3703.6" "4023.3" "3040.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6332903783671194577" "False" "High" "IsMasterProtein" "P62070" "Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1" "0.000" "False" "101.852" "53" "10" "31" "8" "204" "23.4" "6.01" "121.83" "10" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00071" "22800" "ENSG00000133818" "RRAS2" "B2R9Z3; B7Z5Z2; B7Z6C4; B7Z7H6; hsa:22800; P17082; P62070" "RND1 GTPase cycle" "MAPK signaling pathway; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGFR tyrosine kinase inhibitor resistance; Regulation of actin cytoskeleton" "6" "3" "1.103" "1.022" "1.121" "1.064" "1.022" "1.025" "0.962" "0.916" "0.443" "2608.8" "2878.2" "2666.3" "2924.8" "2775.0" "2665.3" "2672.8" "2509.5" "2389.5" "1155.2" "" "" "" "" "" "" "" "" "" "" "2313.4" "2384.2" "2326.5" "2187.3" "2314.0" "2448.4" "2259.0" "2074.3" "2191.5" "1155.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "101.830" "50" "12" "43" "11" "228" "26.2" "8.25" "140.70" "12" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "" "Gastric cancer network 2" "1" "1" "1.012" "1.057" "0.901" "0.989" "0.998" "0.997" "1.042" "1.021" "0.721" "5093.2" "5156.4" "5381.3" "4591.1" "5034.9" "5083.6" "5078.0" "5305.9" "5198.4" "3673.7" "" "" "" "" "" "" "" "" "" "" "4516.5" "4271.3" "4695.5" "3433.6" "4198.4" "4669.8" "4291.7" "4385.7" "4767.7" "3673.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-525798378457225330" "False" "High" "IsMasterProtein" "P0CG39" "POTE ankyrin domain family member J OS=Homo sapiens OX=9606 GN=POTEJ PE=1 SV=1" "0.000" "False" "101.821" "11" "9" "94" "3" "1038" "117.3" "5.97" "309.10" "9" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022, Pf12796, Pf14915" "653781" "ENSG00000222038" "POTEJ" "hsa:653781; P0CG39" "" "" "0" "0" "0.401" "0.395" "0.366" "0.356" "0.420" "0.402" "0.397" "0.380" "0.215" "1523.7" "610.5" "602.4" "557.3" "543.2" "639.4" "612.6" "604.3" "578.9" "327.2" "" "" "" "" "" "" "" "" "" "" "1351.2" "505.7" "525.6" "416.8" "453.0" "587.4" "517.7" "499.5" "530.9" "327.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "101.773" "14" "19" "26" "19" "1729" "181.7" "4.86" "98.43" "19" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "1.006" "0.967" "1.016" "0.975" "1.007" "1.033" "1.071" "1.067" "0.689" "2186.2" "2199.2" "2114.3" "2221.3" "2130.6" "2201.4" "2258.9" "2341.7" "2333.3" "1507.1" "" "" "" "" "" "" "" "" "" "" "1938.7" "1821.7" "1844.8" "1661.2" "1776.6" "2022.3" "1909.1" "1935.6" "2140.0" "1507.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "101.699" "31" "10" "26" "10" "434" "46.7" "4.42" "99.24" "10" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "Nucleotide-binding oligomerization domain (NOD) pathway" "5" "0" "0.974" "0.980" "0.992" "0.973" "1.023" "1.021" "0.993" "0.921" "0.829" "3112.5" "3031.2" "3050.9" "3087.2" "3028.6" "3185.5" "3179.1" "3090.3" "2866.4" "2579.7" "" "" "" "" "" "" "" "" "" "" "2760.1" "2510.9" "2662.0" "2308.8" "2525.4" "2926.2" "2686.8" "2554.4" "2628.9" "2579.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "101.670" "56" "13" "31" "13" "234" "25.5" "8.51" "109.12" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Pyrimidine salvage; G1/S-Specific Transcription" "Fluoropyrimidine activity; Pyrimidine metabolism" "4" "0" "1.023" "1.018" "1.036" "1.054" "1.021" "1.406" "1.450" "1.330" "0.631" "2581.2" "2639.6" "2627.2" "2673.3" "2719.8" "2634.8" "3630.2" "3742.7" "3431.9" "1628.2" "" "" "" "" "" "" "" "" "" "" "2288.9" "2186.5" "2292.4" "1999.3" "2267.9" "2420.3" "3068.1" "3093.6" "3147.6" "1628.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8297311667808919408" "False" "High" "IsMasterProtein" "Q14651" "Plastin-1 OS=Homo sapiens OX=9606 GN=PLS1 PE=1 SV=2" "0.000" "False" "101.628" "28" "16" "34" "11" "629" "70.2" "5.41" "139.42" "16" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00036, Pf00307, Pf13405" "5357" "ENSG00000120756" "PLS1" "A8K2Q1; D3DNG3; hsa:5357; Q14651; Q8NEG6" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "1" "1.008" "0.990" "1.043" "0.979" "0.946" "1.074" "1.049" "0.961" "1.008" "1031.3" "1039.4" "1020.6" "1075.5" "1009.7" "975.6" "1108.1" "1082.2" "990.8" "1039.6" "" "" "" "" "" "" "" "" "" "" "914.5" "861.0" "890.5" "804.3" "841.9" "896.2" "936.5" "894.5" "908.7" "1039.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "101.521" "59" "6" "28" "6" "112" "12.5" "4.78" "127.76" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "22" "0" "1.026" "1.081" "0.852" "0.994" "1.056" "0.948" "1.041" "1.103" "0.865" "3078.3" "3157.4" "3328.7" "2622.3" "3060.9" "3249.8" "2917.1" "3203.6" "3394.8" "2661.5" "" "" "" "" "" "" "" "" "" "" "2729.7" "2615.4" "2904.4" "1961.1" "2552.4" "2985.3" "2465.4" "2648.0" "3113.5" "2661.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "101.517" "44" "10" "31" "10" "295" "32.8" "4.87" "151.05" "10" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.943" "0.912" "0.885" "0.925" "0.843" "0.812" "0.788" "0.855" "0.843" "2726.3" "2569.7" "2486.8" "2413.5" "2520.6" "2299.4" "2214.2" "2148.6" "2329.7" "2297.8" "" "" "" "" "" "" "" "" "" "" "2417.6" "2128.6" "2169.8" "1805.0" "2101.8" "2112.3" "1871.4" "1776.0" "2136.7" "2297.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "101.302" "22" "22" "32" "22" "1037" "117.3" "6.92" "111.21" "22" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "Mitochondrial protein import" "" "1" "0" "0.968" "0.941" "0.968" "0.959" "0.969" "1.049" "1.015" "1.059" "1.349" "2457.3" "2379.6" "2312.8" "2378.3" "2355.6" "2379.9" "2578.6" "2494.2" "2603.2" "3314.9" "" "" "" "" "" "" "" "" "" "" "2179.1" "1971.2" "2018.0" "1778.7" "1964.3" "2186.2" "2179.3" "2061.6" "2387.5" "3314.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "101.222" "32" "12" "51" "12" "374" "39.7" "7.49" "173.66" "12" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Ethanol oxidation" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "3" "0" "1.008" "1.085" "0.988" "1.039" "1.044" "1.035" "1.082" "1.064" "0.576" "3917.3" "3950.0" "4249.6" "3869.4" "4070.2" "4088.8" "4053.5" "4237.8" "4168.6" "2256.4" "" "" "" "" "" "" "" "" "" "" "3473.7" "3272.0" "3708.0" "2893.8" "3394.0" "3756.0" "3425.9" "3502.8" "3823.2" "2256.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "101.192" "20" "19" "25" "19" "1094" "118.2" "7.06" "89.30" "19" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.031" "0.967" "0.994" "0.984" "0.874" "0.972" "0.637" "0.996" "6.247" "1320.6" "1361.9" "1276.8" "1313.3" "1299.0" "1154.8" "1283.0" "841.4" "1315.9" "8250.5" "" "" "" "" "" "" "" "" "" "" "1171.1" "1128.1" "1114.0" "982.1" "1083.2" "1060.8" "1084.4" "695.5" "1206.8" "8250.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "101.016" "40" "9" "30" "9" "265" "30.5" "6.33" "113.24" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "mRNA Splicing - Major Pathway" "" "1" "0" "0.942" "0.932" "0.905" "0.890" "0.896" "0.845" "0.959" "0.956" "0.455" "2812.3" "2650.3" "2620.5" "2545.3" "2503.3" "2520.9" "2376.9" "2697.2" "2689.1" "1278.5" "" "" "" "" "" "" "" "" "" "" "2493.9" "2195.3" "2286.5" "1903.6" "2087.5" "2315.7" "2008.9" "2229.4" "2466.3" "1278.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.000" "False" "100.853" "23" "15" "20" "13" "797" "87.2" "5.36" "90.65" "15" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "1" "1.036" "1.026" "1.051" "1.058" "1.019" "1.004" "0.995" "0.966" "0.858" "1512.3" "1567.0" "1552.4" "1590.1" "1600.7" "1540.5" "1518.6" "1505.1" "1460.7" "1297.5" "" "" "" "" "" "" "" "" "" "" "1341.1" "1298.1" "1354.5" "1189.2" "1334.8" "1415.1" "1283.4" "1244.1" "1339.7" "1297.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "100.641" "23" "15" "24" "14" "709" "81.0" "6.87" "87.17" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "" "12" "0" "1.035" "0.955" "1.068" "1.086" "0.988" "0.998" "1.015" "0.896" "0.374" "1605.3" "1661.4" "1533.0" "1714.8" "1742.8" "1586.2" "1602.3" "1629.5" "1438.7" "600.6" "" "" "" "" "" "" "" "" "" "" "1423.5" "1376.2" "1337.6" "1282.5" "1453.3" "1457.1" "1354.2" "1346.9" "1319.4" "600.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "100.551" "54" "16" "45" "16" "358" "38.8" "5.77" "173.84" "16" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "" "TAR syndrome" "1" "0" "0.953" "0.983" "0.989" "0.974" "0.885" "0.947" "0.986" "1.027" "0.504" "3169.3" "3020.9" "3114.5" "3134.5" "3085.5" "2805.2" "3000.4" "3124.9" "3254.6" "1596.2" "" "" "" "" "" "" "" "" "" "" "2810.4" "2502.4" "2717.6" "2344.2" "2572.9" "2576.9" "2535.9" "2582.9" "2984.9" "1596.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "100.499" "32" "11" "27" "11" "432" "48.5" "6.54" "102.76" "11" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "27" "0" "0.940" "0.996" "1.003" "0.993" "1.005" "1.178" "1.169" "1.221" "0.664" "1628.5" "1530.6" "1622.1" "1633.3" "1617.8" "1637.0" "1918.5" "1903.1" "1988.7" "1081.9" "" "" "" "" "" "" "" "" "" "" "1444.2" "1267.9" "1415.4" "1221.5" "1349.0" "1503.8" "1621.4" "1573.0" "1823.9" "1081.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "100.499" "27" "11" "19" "7" "519" "57.5" "6.58" "81.90" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "2" "0" "0.940" "0.897" "0.873" "0.897" "0.899" "0.819" "0.843" "0.929" "0.899" "1677.4" "1576.5" "1504.8" "1463.5" "1504.1" "1508.1" "1372.9" "1413.9" "1559.1" "1508.8" "" "" "" "" "" "" "" "" "" "" "1487.5" "1305.9" "1313.0" "1094.5" "1254.2" "1385.3" "1160.3" "1168.7" "1429.9" "1508.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563010740913614584" "False" "High" "IsMasterProtein" "Q96EB6" "NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2" "0.000" "False" "100.369" "25" "17" "23" "17" "747" "81.6" "4.67" "89.94" "17" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23411" "ENSG00000096717" "SIRT1" "hsa:23411; Q2XNF6; Q5JVQ0; Q96EB6; Q9GZR9; Q9Y6F0" "SIRT1 negatively regulates rRNA expression; Regulation of HSF1-mediated heat shock response; Heme signaling; Circadian Clock; Regulation of FOXO transcriptional activity by acetylation" "Androgen receptor signaling pathway; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Melatonin metabolism and effects; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Interactions between LOXL4 and oxidative stress pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; CAMKK2 pathway; 3q29 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Inclusion body myositis; Prostaglandin and leukotriene metabolism in senescence ; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; 10q11.21q11.23 copy number variation syndrome; TAR syndrome; Omega-6-fatty acids in senescence" "27" "0" "1.008" "0.982" "1.007" "0.937" "0.928" "0.928" "0.903" "0.935" "1.411" "3077.8" "3102.4" "3021.5" "3100.6" "2884.3" "2854.7" "2857.2" "2777.9" "2879.0" "4341.2" "" "" "" "" "" "" "" "" "" "" "2729.3" "2569.8" "2636.4" "2318.8" "2405.1" "2622.4" "2414.8" "2296.2" "2640.4" "4341.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "100.228" "41" "16" "24" "13" "444" "49.3" "7.23" "85.24" "16" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "2" "0.972" "1.001" "1.034" "1.016" "1.078" "1.382" "1.311" "1.342" "1.838" "2223.2" "2161.3" "2224.9" "2299.6" "2259.7" "2396.0" "3073.2" "2914.2" "2982.9" "4085.7" "" "" "" "" "" "" "" "" "" "" "1971.5" "1790.3" "1941.4" "1719.8" "1884.3" "2201.0" "2597.3" "2408.8" "2735.7" "4085.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5527327330749920032" "False" "High" "IsMasterProtein" "P61019" "Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1" "0.000" "False" "100.125" "68" "12" "27" "5" "212" "23.5" "6.54" "103.86" "12" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "5862" "ENSG00000104388" "RAB2A" "B2R5W8; B4DMQ5; hsa:5862; P08886; P61019" "RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "4" "7" "1.080" "1.020" "1.001" "0.993" "1.038" "0.996" "0.979" "0.913" "0.473" "2765.7" "2987.0" "2819.7" "2769.0" "2747.2" "2871.6" "2754.8" "2707.6" "2525.2" "1307.3" "" "" "" "" "" "" "" "" "" "" "2452.5" "2474.3" "2460.3" "2070.8" "2290.8" "2637.9" "2328.3" "2238.1" "2315.9" "1307.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196973949191465790" "False" "High" "IsMasterProtein" "P07686" "Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=4" "0.000" "False" "100.031" "34" "18" "30" "17" "556" "63.1" "6.76" "107.49" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3074" "ENSG00000049860" "HEXB" "hsa:3074; P07686" "Neutrophil degranulation; CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXB causes GM2G2" "Glycosaminoglycan degradation" "7" "0" "1.032" "1.030" "1.029" "1.051" "1.015" "1.025" "1.054" "1.032" "0.542" "2725.2" "2813.0" "2808.1" "2803.1" "2862.9" "2766.4" "2792.3" "2873.6" "2813.4" "1476.3" "" "" "" "" "" "" "" "" "" "" "2416.7" "2330.1" "2450.2" "2096.3" "2387.3" "2541.3" "2359.9" "2375.2" "2580.3" "1476.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "99.945" "37" "15" "28" "15" "460" "52.3" "7.34" "108.37" "15" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "1.053" "1.074" "1.030" "1.086" "1.122" "1.049" "1.095" "1.144" "0.774" "2162.7" "2277.6" "2322.0" "2227.2" "2348.9" "2426.0" "2269.5" "2368.9" "2474.9" "1675.0" "" "" "" "" "" "" "" "" "" "" "1917.9" "1886.7" "2026.1" "1665.6" "1958.6" "2228.5" "1918.1" "1958.1" "2269.9" "1675.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "99.892" "39" "10" "22" "8" "356" "39.4" "7.20" "95.90" "10" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "1.063" "1.005" "1.115" "1.111" "1.062" "1.113" "1.061" "0.995" "0.618" "934.6" "993.0" "938.8" "1042.3" "1038.6" "992.9" "1040.6" "991.2" "930.0" "577.9" "" "" "" "" "" "" "" "" "" "" "828.8" "822.6" "819.2" "779.5" "866.1" "912.1" "879.5" "819.3" "852.9" "577.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "99.754" "43" "11" "31" "11" "299" "32.8" "4.34" "121.86" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "TAR syndrome" "3" "0" "1.012" "0.997" "0.978" "0.965" "0.968" "0.906" "0.951" "1.013" "0.644" "3061.5" "3096.7" "3051.8" "2993.9" "2953.1" "2962.3" "2773.5" "2911.0" "3100.5" "1970.4" "" "" "" "" "" "" "" "" "" "" "2714.9" "2565.2" "2662.9" "2239.1" "2462.4" "2721.2" "2344.0" "2406.2" "2843.6" "1970.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4007751392279359432" "False" "High" "IsMasterProtein" "Q562R1" "Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2" "0.000" "False" "99.742" "26" "11" "315" "3" "376" "42.0" "5.59" "1075.16" "11" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "345651" "ENSG00000169067" "ACTBL2" "B2RPJ1; hsa:345651; Q562R1; Q562R2; Q562S9; Q562X8" "" "" "0" "0" "1.153" "1.149" "1.097" "1.157" "1.152" "1.034" "1.096" "1.070" "0.779" "186.5" "214.9" "214.3" "204.5" "215.6" "214.8" "192.8" "204.4" "199.4" "145.2" "" "" "" "" "" "" "" "" "" "" "165.3" "178.0" "187.0" "152.9" "179.8" "197.3" "162.9" "168.9" "182.9" "145.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "99.526" "15" "16" "19" "16" "1101" "118.5" "4.81" "77.55" "16" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle" "" "4" "0" "0.994" "0.985" "0.949" "0.926" "0.939" "0.921" "0.914" "1.022" "1.508" "2131.8" "2119.0" "2100.8" "2023.8" "1974.8" "2001.5" "1964.1" "1948.6" "2178.4" "3214.0" "" "" "" "" "" "" "" "" "" "" "1890.4" "1755.3" "1833.0" "1513.5" "1646.7" "1838.6" "1659.9" "1610.7" "1997.9" "3214.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "99.324" "41" "13" "27" "13" "405" "44.5" "6.70" "108.85" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "12" "0" "1.035" "1.042" "1.109" "1.083" "1.082" "1.083" "1.107" "1.059" "0.590" "2894.3" "2996.3" "3014.6" "3210.9" "3134.8" "3131.3" "3133.5" "3202.8" "3064.8" "1708.6" "" "" "" "" "" "" "" "" "" "" "2566.6" "2482.0" "2630.4" "2401.3" "2614.0" "2876.4" "2648.3" "2647.3" "2810.9" "1708.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "99.191" "31" "13" "24" "13" "489" "54.8" "5.16" "101.39" "13" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "Neddylation; KEAP1-NFE2L2 pathway" "3q29 copy number variation syndrome" "3" "0" "1.005" "1.008" "0.975" "0.998" "1.005" "0.987" "1.017" "1.009" "0.836" "2960.2" "2974.4" "2982.5" "2887.4" "2954.4" "2975.4" "2922.0" "3011.4" "2985.4" "2474.7" "" "" "" "" "" "" "" "" "" "" "2625.0" "2463.8" "2602.4" "2159.4" "2463.6" "2733.2" "2469.5" "2489.2" "2738.0" "2474.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "99.076" "38" "6" "27" "6" "205" "23.0" "4.74" "125.38" "6" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "0.970" "0.960" "0.998" "1.023" "0.967" "0.961" "1.008" "0.971" "0.462" "3107.4" "3012.8" "2982.4" "3102.3" "3178.4" "3005.1" "2985.3" "3131.4" "3015.9" "1437.0" "" "" "" "" "" "" "" "" "" "" "2755.5" "2495.7" "2602.3" "2320.1" "2650.4" "2760.5" "2523.1" "2588.3" "2766.0" "1437.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "99.059" "37" "6" "37" "6" "282" "31.3" "4.84" "183.20" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "8" "0" "0.937" "0.888" "0.913" "0.892" "0.843" "1.007" "0.966" "0.946" "1.117" "5182.6" "4857.0" "4604.0" "4729.2" "4624.9" "4370.3" "5217.5" "5005.9" "4901.7" "5788.7" "" "" "" "" "" "" "" "" "" "" "4595.8" "4023.3" "4017.2" "3536.8" "3856.5" "4014.6" "4409.7" "4137.7" "4495.5" "5788.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "99.047" "62" "10" "54" "10" "170" "18.7" "5.03" "205.02" "10" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "1.063" "1.032" "1.099" "1.070" "1.066" "1.019" "1.047" "0.987" "0.594" "3876.0" "4120.5" "3998.5" "4259.2" "4146.4" "4131.5" "3951.1" "4059.0" "3825.8" "2301.8" "" "" "" "" "" "" "" "" "" "" "3437.2" "3413.2" "3488.9" "3185.3" "3457.5" "3795.3" "3339.3" "3355.1" "3508.8" "2301.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "98.814" "34" "13" "26" "13" "455" "51.8" "6.35" "94.24" "13" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.952" "0.996" "0.938" "0.949" "0.971" "0.945" "0.999" "1.060" "0.485" "2870.4" "2731.6" "2858.1" "2693.3" "2723.1" "2786.9" "2713.2" "2866.5" "3042.3" "1392.1" "" "" "" "" "" "" "" "" "" "" "2545.4" "2262.7" "2493.8" "2014.2" "2270.7" "2560.0" "2293.1" "2369.4" "2790.2" "1392.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "98.810" "67" "9" "40" "9" "125" "14.3" "6.04" "123.90" "9" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "0.930" "0.926" "0.964" "0.883" "0.808" "0.818" "0.951" "0.899" "0.444" "6677.5" "6211.2" "6183.1" "6435.1" "5893.0" "5393.8" "5459.0" "6351.3" "6005.0" "2967.6" "" "" "" "" "" "" "" "" "" "" "5921.5" "5145.1" "5395.0" "4812.6" "4914.0" "4954.8" "4613.7" "5249.8" "5507.4" "2967.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "98.761" "42" "13" "44" "13" "288" "32.8" "7.17" "169.99" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "1.050" "1.070" "1.099" "1.077" "0.986" "1.132" "1.075" "1.059" "0.555" "2931.7" "3077.9" "3138.1" "3222.6" "3158.9" "2889.6" "3318.5" "3150.3" "3105.8" "1627.8" "" "" "" "" "" "" "" "" "" "" "2599.8" "2549.6" "2738.1" "2410.1" "2634.1" "2654.5" "2804.6" "2604.0" "2848.4" "1627.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "98.733" "39" "11" "23" "11" "335" "36.4" "6.35" "94.73" "11" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.037" "0.991" "1.093" "1.048" "1.033" "1.029" "1.057" "0.899" "0.527" "2634.1" "2731.0" "2610.4" "2878.3" "2760.4" "2721.1" "2711.7" "2784.5" "2368.2" "1387.5" "" "" "" "" "" "" "" "" "" "" "2335.9" "2262.2" "2277.7" "2152.6" "2301.8" "2499.6" "2291.8" "2301.6" "2172.0" "1387.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "98.703" "61" "10" "33" "10" "198" "21.7" "5.59" "115.30" "10" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "" "5" "0" "1.026" "1.041" "0.990" "1.061" "1.024" "1.000" "1.047" "1.048" "0.548" "4788.7" "4914.9" "4983.5" "4741.6" "5080.6" "4905.2" "4788.4" "5014.5" "5020.3" "2623.7" "" "" "" "" "" "" "" "" "" "" "4246.6" "4071.2" "4348.3" "3546.1" "4236.5" "4505.9" "4047.0" "4144.8" "4604.3" "2623.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "98.688" "46" "7" "22" "7" "198" "22.1" "5.30" "99.37" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "0.955" "0.972" "0.961" "0.959" "1.015" "0.969" "0.992" "0.974" "0.452" "2824.9" "2696.7" "2746.6" "2716.2" "2708.6" "2868.0" "2737.1" "2802.7" "2750.1" "1277.2" "" "" "" "" "" "" "" "" "" "" "2505.1" "2233.8" "2396.5" "2031.3" "2258.6" "2634.6" "2313.2" "2316.6" "2522.2" "1277.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "98.685" "31" "14" "31" "13" "589" "64.1" "8.22" "110.89" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "4" "1" "1.270" "0.974" "1.195" "1.049" "1.075" "0.972" "0.261" "1.016" "19.102" "619.0" "786.1" "603.0" "739.8" "649.6" "665.5" "601.4" "161.5" "628.6" "11823.1" "" "" "" "" "" "" "" "" "" "" "548.9" "651.1" "526.2" "553.3" "541.7" "611.4" "508.3" "133.5" "576.5" "11823.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "98.606" "56" "9" "35" "9" "154" "16.0" "5.60" "158.53" "9" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "1.029" "1.010" "1.050" "1.074" "1.011" "0.998" "1.034" "1.030" "0.523" "3570.1" "3672.7" "3607.1" "3748.6" "3835.2" "3607.9" "3562.4" "3692.0" "3676.4" "1867.4" "" "" "" "" "" "" "" "" "" "" "3165.9" "3042.2" "3147.3" "2803.4" "3198.0" "3314.2" "3010.8" "3051.7" "3371.7" "1867.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "98.396" "38" "19" "24" "19" "567" "65.0" "5.67" "94.08" "19" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "2" "0" "1.002" "1.004" "1.063" "1.008" "0.979" "1.022" "1.059" "0.978" "0.670" "2156.1" "2159.7" "2164.9" "2291.9" "2172.4" "2111.3" "2204.0" "2283.2" "2108.1" "1444.7" "" "" "" "" "" "" "" "" "" "" "1912.0" "1789.0" "1889.0" "1714.0" "1811.5" "1939.4" "1862.7" "1887.2" "1933.4" "1444.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "98.326" "28" "11" "48" "8" "409" "43.1" "4.84" "156.27" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "8" "3" "0.965" "0.988" "1.009" "0.939" "0.965" "0.965" "0.981" "0.956" "0.502" "5550.6" "5354.6" "5486.6" "5603.3" "5209.3" "5358.4" "5354.8" "5447.9" "5307.6" "2786.8" "" "" "" "" "" "" "" "" "" "" "4922.2" "4435.5" "4787.3" "4190.5" "4343.8" "4922.2" "4525.7" "4503.0" "4867.8" "2786.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "98.297" "22" "23" "26" "22" "963" "109.9" "5.57" "92.35" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "1.031" "1.012" "0.916" "0.847" "0.856" "0.824" "0.564" "0.817" "5.969" "1753.3" "1807.3" "1774.1" "1605.6" "1485.2" "1501.7" "1444.3" "988.3" "1431.8" "10465.4" "" "" "" "" "" "" "" "" "" "" "1554.8" "1497.0" "1548.0" "1200.7" "1238.4" "1379.4" "1220.7" "816.9" "1313.2" "10465.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.000" "False" "98.207" "9" "16" "20" "16" "2090" "213.5" "7.47" "74.72" "16" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA" "TGF-beta signaling pathway" "30" "0" "1.040" "0.999" "1.014" "0.997" "0.962" "1.064" "0.881" "1.052" "3.878" "1104.8" "1148.5" "1104.0" "1120.4" "1101.8" "1063.0" "1175.1" "973.5" "1162.4" "4284.3" "" "" "" "" "" "" "" "" "" "" "979.7" "951.4" "963.3" "837.9" "918.8" "976.5" "993.1" "804.7" "1066.0" "4284.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8845776874603627941" "False" "High" "IsMasterProtein" "Q92930" "Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2" "0.000" "False" "98.184" "51" "10" "39" "4" "207" "23.6" "9.07" "145.40" "10" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "51762" "ENSG00000166128" "RAB8B" "hsa:51762; Q5JPC4; Q92930; Q9P293" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "Ectoderm differentiation; Ectoderm differentiation" "5" "0" "0.998" "1.019" "0.988" "0.955" "1.059" "1.014" "1.002" "1.146" "0.721" "1456.7" "1453.6" "1484.6" "1439.0" "1391.4" "1543.3" "1477.5" "1460.1" "1669.6" "1050.7" "" "" "" "" "" "" "" "" "" "" "1291.8" "1204.1" "1295.4" "1076.2" "1160.2" "1417.7" "1248.7" "1206.9" "1531.3" "1050.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516016884332694472" "False" "High" "IsMasterProtein" "O60361" "Putative nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME2P1 PE=5 SV=1" "0.000" "False" "98.147" "66" "8" "69" "1" "137" "15.5" "8.57" "231.23" "8" "other metabolic processes;other biological processes" "" "kinase activity;other molecular function" "Pf00334" "" "" "NME2P1" "O60361" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "0.914" "0.930" "0.907" "0.976" "1.039" "0.892" "1.119" "0.872" "0.210" "932.9" "852.6" "867.4" "846.1" "910.3" "969.0" "832.0" "1043.8" "813.8" "196.3" "" "" "" "" "" "" "" "" "" "" "827.3" "706.3" "756.8" "632.8" "759.1" "890.1" "703.2" "862.8" "746.4" "196.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "98.071" "36" "13" "27" "7" "376" "42.6" "6.64" "108.42" "13" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; Recruitment of NuMA to mitotic centrosomes; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "HDAC6 interactions in the central nervous system" "12" "6" "1.001" "0.984" "1.019" "1.022" "1.032" "1.019" "1.030" "0.940" "0.815" "3658.3" "3661.3" "3599.0" "3728.1" "3737.9" "3773.8" "3729.5" "3766.5" "3437.3" "2980.4" "" "" "" "" "" "" "" "" "" "" "3244.1" "3032.9" "3140.3" "2788.1" "3116.9" "3466.6" "3152.0" "3113.3" "3152.5" "2980.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "98.045" "48" "11" "51" "8" "271" "30.5" "6.29" "181.63" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Neutrophil degranulation" "Selenium micronutrient network" "2" "0" "1.090" "1.090" "1.084" "1.147" "1.159" "1.118" "1.146" "1.122" "0.464" "1443.6" "1573.6" "1573.8" "1564.5" "1655.4" "1673.7" "1613.6" "1653.9" "1620.2" "670.2" "" "" "" "" "" "" "" "" "" "" "1280.1" "1303.5" "1373.3" "1170.0" "1380.4" "1537.4" "1363.8" "1367.1" "1486.0" "670.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "97.857" "42" "15" "25" "13" "404" "46.8" "6.76" "95.30" "15" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "Golgi Associated Vesicle Biogenesis" "" "1" "3" "0.911" "0.911" "0.913" "0.940" "0.845" "1.164" "0.992" "1.107" "3.271" "2152.4" "1960.4" "1961.8" "1966.2" "2023.8" "1817.8" "2506.0" "2136.2" "2382.6" "7040.4" "" "" "" "" "" "" "" "" "" "" "1908.7" "1623.9" "1711.8" "1470.4" "1687.6" "1669.9" "2118.0" "1765.7" "2185.2" "7040.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7324571001266765675" "False" "High" "IsMasterProtein" "P29350" "Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1" "0.000" "False" "97.764" "30" "17" "20" "17" "595" "67.5" "7.78" "77.05" "17" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00102" "5777" "ENSG00000111679" "PTPN6" "A8K306; G3V0F8; hsa:5777; P29350; Q969V8; Q9UK67" "Neutrophil degranulation; PD-1 signaling; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; Signaling by ALK; Regulation of KIT signaling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Interleukin-37 signaling; Platelet sensitization by LDL; PECAM1 interactions; Nuclear events stimulated by ALK signaling in cancer" "Prolactin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; IL-3 signaling pathway; Kit receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways" "33" "0" "0.999" "1.005" "1.075" "1.028" "1.029" "0.965" "0.061" "1.028" "21.007" "651.0" "650.1" "654.1" "699.6" "669.5" "669.6" "628.4" "39.5" "668.9" "13676.1" "" "" "" "" "" "" "" "" "" "" "577.3" "538.5" "570.8" "523.2" "558.3" "615.1" "531.1" "32.6" "613.5" "13676.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "97.728" "32" "17" "33" "17" "559" "61.5" "7.50" "126.05" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "0.993" "0.979" "0.986" "0.977" "1.019" "1.118" "1.145" "1.089" "0.619" "3836.8" "3809.0" "3757.2" "3784.4" "3747.0" "3908.7" "4290.1" "4394.4" "4179.3" "2373.2" "" "" "" "" "" "" "" "" "" "" "3402.4" "3155.2" "3278.3" "2830.2" "3124.5" "3590.6" "3625.8" "3632.2" "3833.0" "2373.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "97.669" "29" "17" "25" "17" "664" "72.6" "7.39" "97.20" "17" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "1.007" "1.020" "1.028" "1.030" "1.075" "1.110" "1.137" "1.083" "0.510" "2489.4" "2505.7" "2540.3" "2559.9" "2564.0" "2676.3" "2763.9" "2830.9" "2696.5" "1269.7" "" "" "" "" "" "" "" "" "" "" "2207.6" "2075.6" "2216.5" "1914.4" "2138.0" "2458.4" "2335.9" "2339.9" "2473.1" "1269.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "97.649" "85" "14" "117" "14" "102" "10.9" "8.92" "401.62" "14" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "RHOG GTPase cycle" "" "1" "0" "0.956" "0.987" "0.982" "0.978" "0.927" "0.943" "0.998" "0.995" "0.392" "15960.1" "15251.0" "15754.5" "15671.1" "15615.8" "14790.6" "15043.8" "15928.2" "15881.0" "6262.7" "" "" "" "" "" "" "" "" "" "" "14153.1" "12633.1" "13746.5" "11719.9" "13021.5" "13586.8" "12714.4" "13165.8" "14565.1" "6262.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "97.561" "47" "15" "21" "15" "404" "45.5" "5.07" "80.86" "15" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "FCGR3A-mediated IL10 synthesis; Factors involved in megakaryocyte development and platelet production; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "22" "0" "1.038" "1.054" "1.026" "1.036" "1.089" "1.207" "1.158" "1.104" "0.751" "1786.1" "1854.7" "1882.9" "1832.7" "1851.0" "1944.4" "2156.5" "2068.3" "1971.3" "1341.8" "" "" "" "" "" "" "" "" "" "" "1583.9" "1536.4" "1643.0" "1370.6" "1543.5" "1786.1" "1822.6" "1709.6" "1808.0" "1341.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "97.556" "40" "12" "27" "12" "339" "39.2" "5.38" "106.87" "12" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "" "16p11.2 proximal deletion syndrome" "1" "0" "0.946" "0.895" "0.961" "0.929" "0.994" "0.963" "0.896" "0.931" "1.264" "1596.2" "1509.7" "1429.0" "1533.4" "1483.1" "1585.9" "1536.6" "1430.1" "1485.8" "2018.0" "" "" "" "" "" "" "" "" "" "" "1415.5" "1250.6" "1246.9" "1146.8" "1236.7" "1456.8" "1298.7" "1182.0" "1362.7" "2018.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386147216843783893" "False" "High" "IsMasterProtein" "Q9NUU7" "ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1" "0.000" "False" "97.530" "34" "16" "25" "16" "478" "53.9" "6.58" "92.15" "16" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55308" "ENSG00000168872" "DDX19A" "B2RPL0; B4DRZ7; hsa:55308; Q53FM0; Q9NUU7" "" "" "0" "0" "1.084" "1.021" "1.059" "1.059" "1.084" "1.282" "1.118" "1.231" "3.656" "2498.6" "2707.3" "2552.0" "2645.1" "2645.2" "2709.5" "3202.0" "2793.7" "3075.8" "9133.7" "" "" "" "" "" "" "" "" "" "" "2215.7" "2242.6" "2226.8" "1978.2" "2205.8" "2489.0" "2706.2" "2309.2" "2820.9" "9133.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "97.515" "27" "16" "38" "16" "586" "65.4" "8.97" "126.86" "16" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "1.044" "1.038" "1.032" "1.028" "1.021" "1.059" "1.062" "1.076" "0.754" "3937.8" "4111.6" "4087.7" "4065.1" "4047.7" "4021.7" "4171.5" "4182.7" "4238.8" "2967.6" "" "" "" "" "" "" "" "" "" "" "3491.9" "3405.9" "3566.7" "3040.1" "3375.2" "3694.4" "3525.6" "3457.3" "3887.5" "2967.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6289921617317730415" "False" "High" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "0.000" "False" "97.367" "45" "14" "22" "14" "364" "40.3" "7.08" "82.35" "14" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "Circadian Clock" "" "1" "0" "1.021" "1.000" "0.988" "0.975" "0.948" "1.042" "0.811" "0.997" "4.879" "1542.0" "1574.3" "1542.6" "1522.8" "1504.2" "1462.3" "1607.5" "1250.9" "1537.2" "7524.2" "" "" "" "" "" "" "" "" "" "" "1367.4" "1304.1" "1346.0" "1138.8" "1254.3" "1343.3" "1358.6" "1034.0" "1409.9" "7524.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "97.308" "45" "8" "32" "6" "183" "20.8" "5.33" "131.39" "8" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "RNA Polymerase I Promoter Escape; Transcriptional Regulation by E2F6; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "6" "2" "0.948" "0.968" "0.946" "0.914" "0.962" "0.933" "0.871" "0.915" "1.336" "4229.1" "4008.0" "4094.2" "4000.5" "3863.4" "4070.4" "3944.0" "3683.2" "3867.8" "5650.3" "" "" "" "" "" "" "" "" "" "" "3750.3" "3320.0" "3572.4" "2991.9" "3221.5" "3739.2" "3333.3" "3044.4" "3547.3" "5650.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.000" "False" "97.296" "42" "13" "25" "13" "314" "35.8" "8.50" "96.04" "13" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "0.969" "1.099" "0.879" "0.952" "1.054" "1.015" "1.081" "1.079" "0.754" "2929.6" "2838.3" "3220.1" "2574.7" "2789.0" "3088.9" "2974.4" "3167.8" "3162.1" "2208.2" "" "" "" "" "" "" "" "" "" "" "2597.9" "2351.1" "2809.7" "1925.5" "2325.6" "2837.5" "2513.8" "2618.4" "2900.1" "2208.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "97.209" "51" "8" "33" "8" "219" "24.3" "4.94" "137.83" "8" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "Phosphate bond hydrolysis by NUDT proteins" "" "1" "0" "1.009" "1.051" "0.981" "1.035" "1.083" "0.980" "1.066" "1.055" "0.490" "5266.7" "5314.3" "5537.7" "5168.9" "5452.8" "5706.0" "5161.3" "5613.7" "5556.0" "2583.1" "" "" "" "" "" "" "" "" "" "" "4670.4" "4402.1" "4831.9" "3865.7" "4546.9" "5241.6" "4362.1" "4640.1" "5095.6" "2583.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "97.169" "46" "16" "19" "16" "386" "43.8" "7.20" "73.74" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "Network map of SARS-CoV-2 signaling pathway" "3" "0" "1.091" "1.023" "1.159" "1.130" "1.035" "1.180" "1.134" "1.028" "1.279" "1586.0" "1729.9" "1622.4" "1838.6" "1792.5" "1641.1" "1871.2" "1798.9" "1630.6" "2029.2" "" "" "" "" "" "" "" "" "" "" "1406.4" "1432.9" "1415.6" "1375.1" "1494.7" "1507.6" "1581.5" "1487.0" "1495.5" "2029.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5022575274388480768" "False" "High" "IsMasterProtein" "P28161" "Glutathione S-transferase Mu 2 OS=Homo sapiens OX=9606 GN=GSTM2 PE=1 SV=2" "0.000" "False" "97.119" "63" "15" "28" "9" "218" "25.7" "6.37" "99.09" "15" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00043, Pf02798" "2946" "ENSG00000213366" "GSTM2" "B4DRY4; E9PEM9; hsa:2946; P28161; Q2M318; Q5TZY5; Q8WWE1" "Glutathione conjugation" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; FOXA2 pathway; Metapathway biotransformation Phase I and II" "6" "7" "0.993" "1.019" "0.992" "1.003" "0.999" "0.987" "1.055" "1.031" "0.612" "4438.7" "4407.1" "4524.9" "4404.0" "4453.4" "4434.0" "4380.3" "4681.1" "4576.6" "2718.7" "" "" "" "" "" "" "" "" "" "" "3936.2" "3650.6" "3948.2" "3293.6" "3713.6" "4073.2" "3702.0" "3869.3" "4197.4" "2718.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4593935513655895610" "False" "High" "IsMasterProtein" "Q13614" "Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4" "0.000" "False" "97.118" "30" "17" "23" "16" "643" "73.3" "7.40" "75.50" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "8898" "ENSG00000087053" "MTMR2" "A6NN98; hsa:8898; Q13614; Q9UPS9" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane" "Intracellular trafficking proteins involved in CMT neuropathy" "5" "0" "1.011" "1.031" "0.909" "1.058" "1.007" "0.977" "1.014" "0.984" "0.572" "3189.5" "3224.6" "3289.2" "2900.4" "3375.7" "3212.5" "3117.0" "3234.0" "3138.9" "1825.0" "" "" "" "" "" "" "" "" "" "" "2828.4" "2671.1" "2870.0" "2169.1" "2814.9" "2951.0" "2634.4" "2673.1" "2878.8" "1825.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "97.086" "35" "15" "40" "14" "482" "54.1" "5.55" "121.99" "15" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "1.044" "1.054" "0.972" "1.037" "0.988" "1.040" "0.997" "1.005" "0.979" "3623.5" "3784.0" "3819.6" "3523.7" "3759.1" "3578.9" "3767.2" "3611.3" "3640.5" "3548.5" "" "" "" "" "" "" "" "" "" "" "3213.3" "3134.5" "3332.8" "2635.3" "3134.6" "3287.6" "3183.9" "2985.0" "3338.9" "3548.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "96.969" "18" "19" "20" "14" "1214" "132.8" "5.69" "84.73" "19" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "7" "4" "0.980" "0.937" "1.028" "0.928" "0.918" "0.935" "0.412" "0.938" "10.057" "1479.1" "1449.0" "1386.0" "1520.2" "1372.7" "1357.9" "1382.9" "609.1" "1387.6" "14875.1" "" "" "" "" "" "" "" "" "" "" "1311.6" "1200.3" "1209.4" "1136.9" "1144.6" "1247.4" "1168.8" "503.4" "1272.6" "14875.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "96.827" "39" "13" "24" "13" "367" "41.0" "9.00" "87.33" "13" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Neutrophil degranulation; Voltage gated Potassium channels" "Metapathway biotransformation Phase I and II" "3" "0" "1.071" "1.062" "1.051" "1.109" "1.050" "1.044" "0.989" "0.983" "0.609" "1666.2" "1785.3" "1769.7" "1751.9" "1848.2" "1749.5" "1739.6" "1647.2" "1637.7" "1015.1" "" "" "" "" "" "" "" "" "" "" "1477.6" "1478.9" "1544.1" "1310.2" "1541.1" "1607.2" "1470.2" "1361.5" "1502.0" "1015.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851715051474233643" "False" "High" "IsMasterProtein" "Q9P2A4" "ABI gene family member 3 OS=Homo sapiens OX=9606 GN=ABI3 PE=1 SV=2" "0.000" "False" "96.730" "37" "11" "25" "11" "366" "39.0" "5.08" "100.24" "11" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "cytoskeletal activity;other molecular function" "Pf07815, Pf14604" "51225" "ENSG00000108798" "ABI3" "C9IZN8; hsa:51225; Q9H0P6; Q9P2A4" "" "" "0" "0" "0.983" "0.986" "1.003" "1.044" "1.002" "0.976" "1.027" "0.952" "0.697" "1600.7" "1574.3" "1577.9" "1605.3" "1671.5" "1603.8" "1561.5" "1643.7" "1523.4" "1116.0" "" "" "" "" "" "" "" "" "" "" "1419.5" "1304.1" "1376.8" "1200.5" "1393.8" "1473.3" "1319.7" "1358.6" "1397.2" "1116.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "High" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.000" "False" "96.719" "41" "11" "20" "11" "374" "42.5" "5.63" "79.38" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "1.076" "0.985" "1.050" "0.998" "0.923" "1.030" "0.765" "0.900" "4.632" "1214.8" "1307.4" "1196.5" "1276.2" "1213.0" "1121.5" "1251.1" "929.7" "1093.0" "5627.6" "" "" "" "" "" "" "" "" "" "" "1077.3" "1082.9" "1044.0" "954.4" "1011.4" "1030.2" "1057.4" "768.4" "1002.5" "5627.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "96.689" "27" "12" "22" "12" "538" "59.1" "5.10" "87.26" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Kleefstra syndrome" "8" "0" "1.027" "1.007" "1.042" "1.051" "1.044" "1.087" "1.074" "1.003" "0.628" "2002.4" "2057.0" "2016.7" "2086.8" "2104.5" "2091.5" "2177.3" "2150.6" "2008.7" "1258.5" "" "" "" "" "" "" "" "" "" "" "1775.7" "1703.9" "1759.7" "1560.7" "1754.8" "1921.2" "1840.2" "1777.6" "1842.2" "1258.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "96.641" "31" "15" "29" "15" "535" "57.2" "8.28" "97.75" "15" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Degradation of GABA" "Fragile X syndrome" "2" "0" "1.021" "0.963" "0.971" "0.998" "1.022" "1.010" "1.011" "0.960" "0.410" "3507.5" "3580.3" "3376.0" "3406.7" "3499.9" "3584.4" "3544.0" "3545.3" "3367.7" "1436.8" "" "" "" "" "" "" "" "" "" "" "3110.4" "2965.8" "2945.7" "2547.8" "2918.4" "3292.7" "2995.2" "2930.5" "3088.6" "1436.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "96.387" "33" "12" "23" "12" "454" "50.1" "8.25" "84.80" "12" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "1.022" "0.991" "1.023" "1.006" "1.077" "1.081" "1.076" "0.942" "0.529" "2606.5" "2663.0" "2584.3" "2665.4" "2620.9" "2806.3" "2816.7" "2805.9" "2454.8" "1379.9" "" "" "" "" "" "" "" "" "" "" "2311.4" "2205.9" "2254.9" "1993.4" "2185.5" "2577.9" "2380.6" "2319.3" "2251.4" "1379.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "96.374" "24" "9" "18" "5" "521" "57.9" "4.96" "89.92" "9" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "Leptin signaling pathway" "3" "0" "1.026" "1.014" "1.024" "1.079" "1.080" "1.012" "1.038" "1.016" "1.229" "739.7" "758.7" "749.8" "757.3" "798.5" "798.7" "748.4" "768.0" "751.5" "909.3" "" "" "" "" "" "" "" "" "" "" "656.0" "628.5" "654.3" "566.3" "665.9" "733.7" "632.6" "634.8" "689.3" "909.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174842833444890787" "False" "High" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "0.000" "False" "96.334" "22" "18" "23" "18" "913" "105.3" "5.68" "82.90" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.923" "0.845" "0.857" "0.748" "0.713" "0.808" "0.683" "0.995" "3.874" "1433.0" "1322.2" "1210.7" "1227.6" "1071.2" "1022.0" "1157.3" "978.0" "1425.9" "5550.6" "" "" "" "" "" "" "" "" "" "" "1270.7" "1095.2" "1056.4" "918.1" "893.2" "938.9" "978.1" "808.4" "1307.7" "5550.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "96.254" "29" "16" "18" "15" "708" "79.8" "5.74" "73.15" "16" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "Synthesis of PIPs at the plasma membrane" "" "1" "1" "1.059" "0.987" "1.097" "1.041" "0.968" "1.086" "0.864" "0.982" "3.856" "1037.8" "1098.8" "1024.1" "1138.4" "1080.3" "1005.1" "1127.1" "896.7" "1018.9" "4001.3" "" "" "" "" "" "" "" "" "" "" "920.3" "910.2" "893.5" "851.3" "900.8" "923.3" "952.6" "741.2" "934.4" "4001.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.000" "False" "96.128" "35" "20" "27" "20" "603" "69.9" "8.18" "95.72" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "1.051" "1.023" "1.076" "1.052" "1.069" "1.042" "1.048" "1.015" "0.679" "1653.3" "1737.5" "1691.7" "1779.1" "1739.0" "1767.6" "1722.2" "1732.7" "1678.4" "1121.8" "" "" "" "" "" "" "" "" "" "" "1466.1" "1439.2" "1476.1" "1330.5" "1450.1" "1623.7" "1455.5" "1432.2" "1539.3" "1121.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "96.040" "40" "8" "34" "8" "270" "29.2" "6.15" "146.47" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Meiotic recombination; Regulation of HSF1-mediated heat shock response; Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "38" "0" "1.015" "1.032" "1.164" "1.185" "1.137" "1.490" "1.551" "1.473" "1.003" "3094.0" "3140.6" "3191.8" "3600.0" "3665.2" "3516.5" "4611.0" "4797.6" "4556.9" "3103.2" "" "" "" "" "" "" "" "" "" "" "2743.7" "2601.5" "2785.0" "2692.3" "3056.3" "3230.3" "3897.0" "3965.5" "4179.3" "3103.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "96.021" "54" "16" "42" "11" "270" "31.8" "6.55" "126.49" "16" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "" "2" "0" "0.967" "0.973" "0.916" "0.923" "0.995" "0.955" "1.000" "0.922" "0.497" "3278.3" "3169.4" "3189.3" "3002.1" "3024.9" "3261.5" "3130.5" "3277.4" "3022.3" "1627.9" "" "" "" "" "" "" "" "" "" "" "2907.2" "2625.4" "2782.8" "2245.1" "2522.3" "2996.1" "2645.8" "2709.0" "2771.8" "1627.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "95.978" "84" "8" "33" "8" "114" "12.8" "5.25" "143.62" "8" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "0.953" "0.936" "0.875" "0.880" "0.917" "0.848" "0.914" "0.919" "0.562" "6883.4" "6561.6" "6443.5" "6020.7" "6059.0" "6311.9" "5835.7" "6289.4" "6329.3" "3870.6" "" "" "" "" "" "" "" "" "" "" "6104.1" "5435.3" "5622.3" "4502.7" "5052.4" "5798.2" "4932.1" "5198.6" "5804.8" "3870.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "95.918" "41" "14" "24" "14" "377" "41.9" "6.65" "84.69" "14" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "1.015" "1.060" "1.057" "1.060" "1.062" "1.052" "1.098" "1.059" "0.491" "2397.6" "2434.3" "2542.5" "2534.4" "2542.5" "2547.1" "2522.9" "2633.2" "2539.3" "1177.8" "" "" "" "" "" "" "" "" "" "" "2126.1" "2016.4" "2218.4" "1895.4" "2120.1" "2339.8" "2132.2" "2176.6" "2328.9" "1177.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5091177938667012153" "False" "High" "IsMasterProtein" "P41743" "Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2" "0.000" "False" "95.840" "32" "15" "24" "12" "596" "68.2" "5.85" "92.00" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5584" "ENSG00000163558" "PRKCI" "D3DNQ4; hsa:5584; P41743; Q8WW06" "KEAP1-NFE2L2 pathway; Tight junction interactions; Pre-NOTCH Transcription and Translation; p75NTR recruits signalling complexes" "Glioblastoma signaling pathways; Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Chronic hyperglycemia impairment of neuron function" "15" "4" "1.041" "1.019" "1.074" "1.065" "1.072" "1.080" "1.088" "1.078" "1.264" "1458.8" "1518.5" "1486.4" "1566.5" "1553.5" "1564.2" "1575.6" "1587.1" "1572.0" "1844.6" "" "" "" "" "" "" "" "" "" "" "1293.6" "1257.9" "1297.0" "1171.6" "1295.4" "1436.9" "1331.6" "1311.8" "1441.7" "1844.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "95.839" "59" "8" "32" "8" "182" "20.4" "7.24" "138.91" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Trafficking of myristoylated proteins to the cilium" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "5" "0" "1.048" "1.048" "1.137" "1.092" "1.037" "1.087" "1.121" "1.062" "0.535" "2053.1" "2151.9" "2152.6" "2334.4" "2242.6" "2128.7" "2231.5" "2301.7" "2181.1" "1099.1" "" "" "" "" "" "" "" "" "" "" "1820.6" "1782.5" "1878.2" "1745.8" "1870.1" "1955.5" "1886.0" "1902.5" "2000.4" "1099.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5513100547130879649" "False" "High" "IsMasterProtein" "P13797" "Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4" "0.000" "False" "95.698" "15" "10" "98" "1" "630" "70.8" "5.60" "324.92" "10" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf13499" "5358" "ENSG00000102024" "PLS3" "A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6" "" "" "0" "0" "0.974" "1.083" "1.079" "0.935" "1.024" "1.097" "1.091" "0.879" "0.502" "337.7" "328.9" "365.8" "364.3" "315.7" "346.0" "370.5" "368.5" "296.8" "169.4" "" "" "" "" "" "" "" "" "" "" "299.5" "272.5" "319.2" "272.5" "263.3" "317.8" "313.2" "304.6" "272.2" "169.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "95.542" "39" "7" "27" "7" "230" "24.7" "6.77" "110.69" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "RAS processing; eNOS activation" "" "2" "0" "1.006" "1.024" "1.002" "1.031" "1.020" "0.989" "1.030" "0.970" "0.486" "3893.5" "3916.8" "3986.0" "3900.3" "4014.2" "3970.4" "3851.9" "4010.4" "3776.4" "1893.4" "" "" "" "" "" "" "" "" "" "" "3452.7" "3244.5" "3478.0" "2916.9" "3347.3" "3647.2" "3255.5" "3314.9" "3463.5" "1893.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "95.521" "41" "12" "21" "12" "323" "37.1" "5.92" "93.44" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "mRNA Splicing - Major Pathway" "" "1" "0" "1.029" "1.077" "0.993" "1.012" "1.036" "0.939" "0.964" "1.040" "0.761" "1052.1" "1082.5" "1132.6" "1045.0" "1064.7" "1089.7" "987.7" "1014.0" "1094.6" "800.8" "" "" "" "" "" "" "" "" "" "" "932.9" "896.7" "988.2" "781.5" "887.8" "1001.0" "834.7" "838.1" "1003.9" "800.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "95.464" "31" "7" "24" "7" "273" "28.9" "7.81" "96.49" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "Regulation of PTEN stability and activity; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "0.920" "0.914" "0.931" "0.924" "0.938" "0.928" "0.926" "0.850" "0.614" "2207.7" "2031.7" "2017.4" "2054.5" "2040.5" "2069.8" "2047.7" "2043.3" "1877.4" "1356.0" "" "" "" "" "" "" "" "" "" "" "1957.7" "1683.0" "1760.3" "1536.5" "1701.5" "1901.3" "1730.7" "1688.9" "1721.8" "1356.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "95.386" "56" "10" "17" "10" "244" "25.8" "7.37" "75.79" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "Phenylalanine metabolism" "" "1" "0" "1.014" "1.020" "1.086" "1.085" "1.092" "1.144" "1.142" "1.002" "0.496" "1578.1" "1600.6" "1610.1" "1713.3" "1713.0" "1722.9" "1804.8" "1802.1" "1581.0" "783.0" "" "" "" "" "" "" "" "" "" "" "1399.4" "1325.8" "1404.9" "1281.3" "1428.4" "1582.7" "1525.3" "1489.6" "1450.0" "783.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "95.176" "50" "9" "18" "9" "205" "22.9" "4.63" "80.00" "9" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "Neutrophil degranulation" "" "1" "0" "0.961" "0.976" "0.934" "0.972" "1.033" "0.928" "0.952" "0.959" "0.690" "2087.7" "2006.6" "2038.5" "1951.0" "2029.3" "2156.5" "1938.2" "1987.4" "2002.7" "1440.6" "" "" "" "" "" "" "" "" "" "" "1851.4" "1662.2" "1778.7" "1459.1" "1692.2" "1980.9" "1638.1" "1642.7" "1836.8" "1440.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "95.106" "48" "13" "48" "13" "239" "27.4" "5.73" "158.36" "13" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Ub-specific processing proteases; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity" "Proteasome degradation" "61" "0" "1.009" "1.018" "1.059" "0.975" "1.109" "1.035" "1.056" "0.970" "0.513" "6538.9" "6595.1" "6655.6" "6925.3" "6376.7" "7249.0" "6765.9" "6902.7" "6341.2" "3352.2" "" "" "" "" "" "" "" "" "" "" "5798.6" "5463.1" "5807.3" "5179.2" "5317.3" "6659.0" "5718.3" "5705.6" "5815.8" "3352.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "95.100" "38" "9" "19" "9" "264" "29.6" "6.15" "74.16" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "Ciliary landscape" "5" "0" "1.043" "1.053" "1.038" "1.112" "1.021" "1.069" "1.036" "1.045" "0.566" "1239.3" "1292.8" "1304.6" "1285.8" "1378.3" "1265.6" "1325.4" "1284.4" "1294.7" "700.9" "" "" "" "" "" "" "" "" "" "" "1099.0" "1070.9" "1138.3" "961.6" "1149.3" "1162.6" "1120.2" "1061.6" "1187.4" "700.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "95.043" "34" "15" "28" "15" "501" "54.1" "8.66" "100.20" "15" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "Amino acid metabolism" "5" "0" "0.990" "0.986" "1.008" "0.992" "0.990" "1.014" "1.002" "0.984" "0.436" "3991.0" "3950.7" "3936.5" "4023.0" "3960.6" "3953.0" "4046.4" "3998.1" "3927.4" "1741.6" "" "" "" "" "" "" "" "" "" "" "3539.2" "3272.6" "3434.8" "3008.7" "3302.6" "3631.3" "3419.8" "3304.7" "3602.0" "1741.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "High" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.000" "False" "95.037" "45" "14" "29" "14" "360" "39.6" "8.09" "108.72" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "Amino acids regulate mTORC1" "" "1" "0" "1.131" "0.993" "1.036" "1.059" "1.079" "0.987" "0.969" "0.895" "0.735" "3147.8" "3561.0" "3125.6" "3260.7" "3332.9" "3397.3" "3108.0" "3050.9" "2816.9" "2313.2" "" "" "" "" "" "" "" "" "" "" "2791.4" "2949.8" "2727.3" "2438.6" "2779.2" "3120.8" "2626.7" "2521.8" "2583.5" "2313.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "94.865" "31" "15" "27" "15" "452" "51.3" "8.32" "95.90" "15" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "Mitochondrial protein import" "" "1" "0" "1.045" "0.988" "1.042" "0.984" "0.888" "0.924" "0.913" "0.972" "0.938" "2715.4" "2837.7" "2683.4" "2829.0" "2671.9" "2410.9" "2508.6" "2479.6" "2640.5" "2548.2" "" "" "" "" "" "" "" "" "" "" "2407.9" "2350.6" "2341.4" "2115.7" "2228.0" "2214.6" "2120.2" "2049.6" "2421.7" "2548.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778501702482241288" "False" "High" "IsMasterProtein" "P41182" "B-cell lymphoma 6 protein OS=Homo sapiens OX=9606 GN=BCL6 PE=1 SV=1" "0.000" "False" "94.745" "26" "17" "26" "17" "706" "78.8" "7.94" "106.01" "17" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "604" "ENSG00000113916" "BCL6" "A7E241; B8PSA7; D3DNV5; hsa:604; P41182" "Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; FOXO-mediated transcription of cell death genes" "B cell receptor signaling pathway; Vitamin D receptor pathway; MECP2 and associated Rett syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Extrafollicular and follicular B cell activation by SARS-CoV-2; DNA damage response (only ATM dependent)" "9" "0" "1.012" "1.009" "1.032" "1.026" "0.961" "0.902" "0.888" "0.878" "0.899" "2102.5" "2126.9" "2121.2" "2170.4" "2157.7" "2021.1" "1896.4" "1867.2" "1846.9" "1889.2" "" "" "" "" "" "" "" "" "" "" "1864.4" "1761.8" "1850.8" "1623.2" "1799.2" "1856.6" "1602.7" "1543.4" "1693.8" "1889.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "94.664" "56" "13" "32" "13" "227" "25.6" "9.16" "115.08" "13" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "Factors involved in megakaryocyte development and platelet production" "" "1" "0" "0.998" "0.992" "1.032" "1.024" "1.031" "1.075" "1.094" "0.972" "0.412" "4132.2" "4125.1" "4097.4" "4265.1" "4231.0" "4259.8" "4443.2" "4521.2" "4016.9" "1704.1" "" "" "" "" "" "" "" "" "" "" "3664.4" "3417.0" "3575.1" "3189.8" "3528.1" "3913.1" "3755.2" "3737.1" "3684.0" "1704.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "94.603" "42" "13" "23" "13" "372" "42.4" "5.80" "90.50" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "0.980" "0.996" "1.111" "1.018" "0.993" "1.029" "1.026" "1.018" "0.659" "1872.0" "1834.6" "1865.3" "2079.4" "1906.4" "1858.8" "1926.0" "1920.6" "1905.3" "1234.3" "" "" "" "" "" "" "" "" "" "" "1660.1" "1519.7" "1627.6" "1555.1" "1589.7" "1707.5" "1627.8" "1587.5" "1747.4" "1234.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.000" "False" "94.498" "33" "14" "30" "14" "464" "50.8" "8.21" "98.62" "14" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "7" "0" "0.937" "0.971" "1.002" "1.011" "1.044" "1.089" "1.095" "1.020" "0.287" "2581.5" "2420.1" "2505.5" "2587.8" "2609.5" "2695.6" "2811.1" "2827.9" "2634.3" "741.7" "" "" "" "" "" "" "" "" "" "" "2289.2" "2004.7" "2186.2" "1935.3" "2176.0" "2476.2" "2375.8" "2337.5" "2416.0" "741.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "94.485" "20" "21" "24" "20" "1041" "119.2" "6.80" "89.76" "21" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.934" "0.884" "0.920" "0.855" "0.905" "0.862" "0.754" "0.859" "2.203" "2759.9" "2578.9" "2440.5" "2540.4" "2360.4" "2496.5" "2378.0" "2081.3" "2371.5" "6080.2" "" "" "" "" "" "" "" "" "" "" "2447.5" "2136.2" "2129.5" "1899.9" "1968.3" "2293.3" "2009.8" "1720.3" "2175.0" "6080.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4396257609671438072" "False" "High" "IsMasterProtein" "Q8IZL8" "Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2" "0.000" "False" "94.427" "13" "12" "16" "12" "1130" "119.6" "4.34" "64.86" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08166, Pf08167" "27043" "ENSG00000141456" "PELP1" "hsa:27043; O15450; Q5EGN3; Q6NTE6; Q8IZL8; Q96FT1; Q9BU60" "Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression" "" "2" "0" "1.197" "1.058" "1.324" "1.212" "1.024" "0.937" "0.935" "0.825" "0.368" "1045.1" "1251.3" "1105.7" "1383.5" "1267.1" "1070.6" "979.1" "977.6" "862.5" "384.7" "" "" "" "" "" "" "" "" "" "" "926.8" "1036.5" "964.8" "1034.7" "1056.6" "983.4" "827.5" "808.0" "791.0" "384.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "94.264" "25" "14" "23" "13" "637" "72.7" "6.09" "88.94" "14" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "17" "0" "1.063" "0.946" "1.049" "0.976" "0.986" "1.068" "1.059" "0.883" "0.679" "1497.5" "1592.5" "1416.2" "1571.0" "1461.6" "1476.2" "1600.1" "1585.4" "1322.7" "1017.3" "" "" "" "" "" "" "" "" "" "" "1328.0" "1319.2" "1235.7" "1174.9" "1218.8" "1356.0" "1352.3" "1310.4" "1213.1" "1017.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "94.198" "48" "12" "20" "11" "343" "38.8" "5.69" "70.98" "12" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "mRNA Splicing - Major Pathway" "" "1" "1" "0.943" "0.995" "0.952" "0.953" "1.035" "0.927" "1.019" "1.055" "0.404" "2189.4" "2064.7" "2179.4" "2085.1" "2086.4" "2266.0" "2029.4" "2231.9" "2309.6" "883.5" "" "" "" "" "" "" "" "" "" "" "1941.5" "1710.3" "1901.6" "1559.4" "1739.8" "2081.5" "1715.2" "1844.8" "2118.2" "883.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "94.165" "37" "8" "19" "8" "276" "30.0" "5.30" "81.02" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.038" "1.028" "1.051" "1.045" "1.019" "1.085" "1.039" "0.975" "0.374" "2543.1" "2640.9" "2613.1" "2672.4" "2656.3" "2590.7" "2760.5" "2641.3" "2480.7" "950.7" "" "" "" "" "" "" "" "" "" "" "2255.2" "2187.6" "2280.0" "1998.6" "2215.0" "2379.9" "2333.1" "2183.2" "2275.2" "950.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "93.922" "19" "17" "28" "17" "975" "112.5" "5.25" "100.62" "17" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "1.035" "0.977" "1.015" "1.004" "0.962" "0.961" "0.994" "0.881" "0.843" "2674.9" "2767.3" "2612.3" "2714.0" "2686.5" "2573.1" "2571.9" "2658.7" "2357.4" "2254.3" "" "" "" "" "" "" "" "" "" "" "2372.0" "2292.3" "2279.4" "2029.7" "2240.2" "2363.7" "2173.6" "2197.6" "2162.1" "2254.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "93.878" "25" "11" "22" "8" "557" "59.6" "9.16" "89.05" "11" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "5" "2" "0.988" "0.991" "0.952" "0.938" "0.965" "0.932" "0.733" "0.973" "4.585" "1320.2" "1304.9" "1308.7" "1256.6" "1238.5" "1273.4" "1230.2" "967.9" "1284.3" "6053.6" "" "" "" "" "" "" "" "" "" "" "1170.7" "1080.9" "1141.9" "939.8" "1032.7" "1169.8" "1039.7" "800.0" "1177.9" "6053.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "93.815" "13" "17" "21" "15" "1490" "164.1" "9.44" "81.34" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "TP53 Regulates Transcription of DNA Repair Genes" "17q12 copy number variation syndrome" "2" "1" "0.932" "0.943" "1.019" "0.944" "0.910" "0.875" "0.947" "0.934" "0.672" "2204.5" "2055.4" "2079.8" "2246.3" "2081.9" "2005.5" "1929.9" "2086.9" "2058.3" "1481.6" "" "" "" "" "" "" "" "" "" "" "1954.9" "1702.6" "1814.7" "1679.9" "1736.0" "1842.3" "1631.1" "1724.9" "1887.8" "1481.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "93.805" "35" "13" "19" "13" "431" "48.3" "6.58" "76.15" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.081" "1.057" "1.160" "1.017" "1.042" "1.131" "1.114" "1.123" "0.708" "2201.9" "2380.5" "2328.0" "2553.7" "2238.7" "2295.4" "2490.6" "2454.0" "2472.2" "1558.5" "" "" "" "" "" "" "" "" "" "" "1952.6" "1971.9" "2031.3" "1909.8" "1866.8" "2108.6" "2104.9" "2028.4" "2267.4" "1558.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.000" "False" "93.595" "7" "18" "21" "18" "2799" "309.2" "5.85" "66.51" "18" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "" "Mesodermal commitment pathway" "1" "0" "1.031" "1.075" "1.144" "1.006" "0.986" "1.075" "0.901" "0.998" "3.117" "237.9" "245.2" "255.7" "272.1" "239.2" "234.5" "255.7" "214.4" "237.5" "741.6" "" "" "" "" "" "" "" "" "" "" "211.0" "203.1" "223.1" "203.5" "199.5" "215.4" "216.1" "177.2" "217.8" "741.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "93.577" "54" "11" "24" "11" "217" "24.3" "8.12" "96.87" "11" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "Mitochondrial protein import" "" "1" "0" "1.000" "0.998" "0.902" "0.876" "0.992" "0.855" "0.877" "0.921" "0.642" "2958.0" "2957.2" "2953.4" "2666.7" "2591.9" "2934.5" "2529.4" "2593.1" "2725.1" "1898.2" "" "" "" "" "" "" "" "" "" "" "2623.1" "2449.6" "2577.0" "1994.3" "2161.3" "2695.7" "2137.7" "2143.4" "2499.3" "1898.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "93.554" "44" "10" "43" "9" "305" "30.8" "9.29" "140.91" "10" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "1.009" "0.982" "1.029" "0.987" "1.022" "1.012" "0.600" "1.011" "8.326" "1157.2" "1167.7" "1136.7" "1190.5" "1142.6" "1183.0" "1171.4" "694.2" "1170.0" "9635.6" "" "" "" "" "" "" "" "" "" "" "1026.2" "967.2" "991.8" "890.4" "952.8" "1086.7" "990.0" "573.8" "1073.1" "9635.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4495210949063335174" "False" "High" "IsMasterProtein" "Q7L576" "Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1" "0.000" "False" "93.442" "14" "19" "29" "1" "1253" "145.1" "6.90" "93.81" "19" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf05994, Pf07159" "23191" "ENSG00000273749; ENSG00000288461" "CYFIP1" "A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway" "15" "0" "1.194" "1.237" "0.856" "1.092" "1.135" "1.129" "1.186" "2.226" "0.993" "118.9" "141.9" "147.1" "101.7" "129.8" "134.9" "134.2" "141.0" "264.6" "118.1" "" "" "" "" "" "" "" "" "" "" "105.4" "117.6" "128.3" "76.1" "108.3" "123.9" "113.4" "116.5" "242.7" "118.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036533815918111608" "False" "High" "IsMasterProtein" "Q9NP72" "Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1" "0.000" "False" "93.147" "60" "11" "20" "11" "206" "23.0" "5.24" "82.04" "11" "cell organization and biogenesis;transport;developmental processes;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "22931" "ENSG00000099246" "RAB18" "B3KMC7; B7Z333; D3DRW1; hsa:22931; Q53FX8; Q56UN9; Q6FIH1; Q9NP72" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPI-independent Golgi-to-ER retrograde traffic" "" "4" "0" "1.010" "1.027" "1.073" "1.037" "1.023" "1.012" "0.985" "0.931" "0.490" "2447.0" "2472.0" "2513.0" "2626.2" "2538.5" "2502.3" "2475.9" "2409.6" "2277.4" "1199.1" "" "" "" "" "" "" "" "" "" "" "2169.9" "2047.7" "2192.7" "1964.1" "2116.7" "2298.6" "2092.5" "1991.7" "2088.7" "1199.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "93.084" "43" "14" "31" "14" "351" "39.0" "6.16" "112.40" "14" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Recycling of eIF2:GDP" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "5" "0" "1.000" "1.034" "1.067" "1.049" "0.993" "1.056" "1.071" "1.003" "0.728" "2292.6" "2293.2" "2370.1" "2445.9" "2404.1" "2277.3" "2420.4" "2454.5" "2300.0" "1668.6" "" "" "" "" "" "" "" "" "" "" "2033.1" "1899.5" "2068.0" "1829.2" "2004.7" "2092.0" "2045.6" "2028.9" "2109.4" "1668.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "93.076" "22" "20" "29" "19" "893" "97.8" "5.66" "103.45" "20" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "1.035" "0.997" "1.058" "1.046" "1.086" "1.218" "1.203" "1.184" "0.662" "2484.0" "2570.3" "2476.3" "2627.2" "2598.4" "2696.8" "3024.9" "2988.8" "2941.2" "1644.5" "" "" "" "" "" "" "" "" "" "" "2202.7" "2129.1" "2160.7" "1964.8" "2166.7" "2477.3" "2556.5" "2470.4" "2697.5" "1644.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "93.039" "46" "10" "20" "10" "200" "22.4" "5.44" "83.20" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "" "3" "0" "1.050" "1.058" "1.078" "1.067" "1.046" "1.052" "1.034" "1.037" "0.638" "2307.9" "2422.5" "2442.3" "2487.1" "2461.5" "2414.3" "2428.1" "2387.4" "2393.2" "1473.2" "" "" "" "" "" "" "" "" "" "" "2046.6" "2006.7" "2131.1" "1860.0" "2052.6" "2217.8" "2052.1" "1973.3" "2194.9" "1473.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.000" "False" "92.975" "49" "11" "23" "10" "263" "28.3" "8.38" "92.71" "11" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "1" "0.986" "1.012" "1.004" "0.958" "1.019" "1.024" "1.023" "0.986" "0.723" "1762.7" "1738.3" "1783.1" "1770.5" "1688.2" "1796.7" "1804.8" "1802.7" "1737.2" "1274.4" "" "" "" "" "" "" "" "" "" "" "1563.1" "1439.9" "1555.8" "1324.1" "1407.8" "1650.5" "1525.4" "1490.1" "1593.3" "1274.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "92.775" "22" "14" "23" "14" "623" "71.2" "7.37" "86.56" "14" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "NFE2L2 regulating MDR associated enzymes" "VEGFA-VEGFR2 signaling" "2" "0" "1.005" "1.017" "1.234" "1.260" "1.267" "1.843" "1.637" "1.560" "1.376" "1725.1" "1734.0" "1754.9" "2128.5" "2173.5" "2186.1" "3178.9" "2824.0" "2691.6" "2373.6" "" "" "" "" "" "" "" "" "" "" "1529.8" "1436.4" "1531.2" "1591.8" "1812.4" "2008.1" "2686.7" "2334.2" "2468.6" "2373.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "92.621" "30" "15" "21" "15" "542" "63.2" "5.11" "84.32" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "Protein hydroxylation" "" "1" "0" "0.978" "0.969" "1.010" "1.035" "1.068" "1.083" "1.073" "1.039" "1.070" "2594.1" "2536.1" "2514.9" "2619.6" "2685.0" "2770.2" "2809.7" "2782.3" "2694.4" "2776.8" "" "" "" "" "" "" "" "" "" "" "2300.4" "2100.8" "2194.4" "1959.1" "2239.0" "2544.8" "2374.6" "2299.8" "2471.1" "2776.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "92.607" "27" "18" "27" "17" "703" "77.6" "6.95" "92.78" "18" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "0.955" "0.913" "0.914" "0.960" "0.885" "0.882" "0.706" "0.886" "3.339" "1369.7" "1308.7" "1250.0" "1251.8" "1314.6" "1211.6" "1207.9" "967.3" "1213.2" "4572.9" "" "" "" "" "" "" "" "" "" "" "1214.6" "1084.1" "1090.7" "936.2" "1096.2" "1113.0" "1020.9" "799.5" "1112.7" "4572.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "92.578" "45" "12" "20" "12" "272" "28.2" "6.28" "81.42" "12" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.033" "0.997" "1.105" "1.062" "0.998" "1.042" "1.061" "0.890" "0.352" "1798.0" "1857.6" "1793.4" "1987.6" "1909.1" "1794.1" "1873.2" "1908.2" "1600.8" "632.9" "" "" "" "" "" "" "" "" "" "" "1594.5" "1538.7" "1564.9" "1486.4" "1592.0" "1648.1" "1583.2" "1577.2" "1468.1" "632.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "92.577" "26" "13" "25" "13" "544" "61.5" "5.47" "89.51" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "1.087" "1.053" "1.071" "1.075" "1.085" "1.121" "1.086" "1.065" "0.674" "2281.4" "2479.0" "2402.0" "2444.4" "2453.5" "2474.5" "2557.2" "2476.9" "2430.5" "1538.3" "" "" "" "" "" "" "" "" "" "" "2023.1" "2053.5" "2095.9" "1828.1" "2045.9" "2273.1" "2161.2" "2047.4" "2229.1" "1538.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "92.533" "9" "13" "18" "13" "1833" "193.9" "6.76" "66.37" "13" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "" "18" "0" "0.989" "1.006" "0.998" "1.010" "1.081" "0.966" "1.033" "0.977" "0.748" "1164.4" "1151.5" "1171.9" "1161.6" "1176.6" "1259.1" "1125.0" "1202.3" "1138.2" "870.9" "" "" "" "" "" "" "" "" "" "" "1032.6" "953.8" "1022.5" "868.7" "981.1" "1156.6" "950.8" "993.8" "1043.8" "870.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "92.520" "40" "8" "20" "8" "250" "27.4" "8.60" "89.03" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "Vitamin B12 metabolism" "3" "0" "1.043" "0.992" "1.070" "1.047" "1.109" "1.050" "1.118" "1.065" "0.517" "1903.8" "1985.9" "1889.2" "2037.8" "1994.1" "2111.1" "1999.4" "2128.0" "2028.2" "984.5" "" "" "" "" "" "" "" "" "" "" "1688.3" "1645.0" "1648.5" "1524.0" "1662.8" "1939.3" "1689.8" "1758.9" "1860.2" "984.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "92.379" "46" "10" "28" "10" "193" "21.8" "6.10" "110.15" "10" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; VEGFA-VEGFR2 Pathway; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "71" "0" "0.904" "1.023" "0.872" "0.939" "0.988" "0.884" "0.871" "1.034" "0.756" "3897.0" "3523.4" "3987.5" "3398.2" "3661.2" "3848.6" "3443.9" "3394.2" "4030.6" "2945.1" "" "" "" "" "" "" "" "" "" "" "3455.8" "2918.6" "3479.3" "2541.4" "3052.9" "3535.4" "2910.6" "2805.6" "3696.7" "2945.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "92.330" "44" "18" "23" "18" "441" "49.4" "9.91" "94.43" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "1.004" "0.989" "0.929" "0.904" "0.854" "0.732" "0.707" "0.764" "1.011" "3346.5" "3360.1" "3309.5" "3107.7" "3025.2" "2858.6" "2448.0" "2367.2" "2558.0" "3381.7" "" "" "" "" "" "" "" "" "" "" "2967.6" "2783.3" "2887.7" "2324.2" "2522.6" "2626.0" "2069.0" "1956.6" "2346.1" "3381.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "92.276" "44" "11" "32" "11" "226" "26.1" "8.00" "111.83" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "Insulin receptor recycling; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Transferrin endocytosis and recycling; Ion channel transport" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "7" "0" "0.997" "1.006" "1.040" "1.005" "0.984" "1.023" "1.011" "0.994" "0.737" "2829.5" "2820.0" "2846.8" "2941.8" "2843.3" "2785.4" "2894.2" "2859.4" "2811.7" "2086.3" "" "" "" "" "" "" "" "" "" "" "2509.1" "2336.0" "2484.0" "2200.1" "2371.0" "2558.7" "2446.0" "2363.5" "2578.7" "2086.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "92.259" "27" "14" "58" "2" "427" "49.1" "5.68" "164.55" "14" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.017" "0.903" "0.984" "0.928" "0.930" "1.056" "0.079" "1.091" "13.428" "128.1" "130.3" "115.7" "126.0" "118.9" "119.1" "135.3" "10.2" "139.8" "1720.7" "" "" "" "" "" "" "" "" "" "" "113.6" "107.9" "101.0" "94.3" "99.1" "109.5" "114.4" "8.4" "128.2" "1720.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "92.145" "46" "8" "18" "8" "268" "28.1" "8.27" "83.21" "8" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "" "Gastric cancer network 1" "1" "0" "0.968" "0.971" "1.004" "0.972" "1.017" "0.952" "0.990" "0.958" "0.397" "2550.2" "2468.6" "2476.0" "2561.6" "2478.3" "2592.3" "2428.0" "2525.8" "2444.0" "1013.1" "" "" "" "" "" "" "" "" "" "" "2261.5" "2044.9" "2160.4" "1915.7" "2066.6" "2381.3" "2052.0" "2087.7" "2241.5" "1013.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "High" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.000" "False" "92.095" "34" "11" "27" "11" "314" "35.8" "4.74" "104.52" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Macroautophagy" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "6" "0" "0.964" "1.010" "0.939" "0.963" "1.052" "1.018" "1.044" "1.044" "0.711" "2651.5" "2555.7" "2679.1" "2489.0" "2552.7" "2790.4" "2699.5" "2767.5" "2767.0" "1885.7" "" "" "" "" "" "" "" "" "" "" "2351.3" "2117.0" "2337.6" "1861.4" "2128.6" "2563.3" "2281.5" "2287.5" "2537.7" "1885.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "91.928" "13" "17" "23" "17" "1720" "194.7" "7.03" "81.36" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "0.952" "0.878" "1.071" "0.938" "0.971" "1.339" "1.296" "1.211" "1.251" "1921.6" "1829.8" "1687.6" "2058.7" "1801.9" "1865.7" "2573.1" "2491.2" "2326.9" "2404.7" "" "" "" "" "" "" "" "" "" "" "1704.0" "1515.7" "1472.5" "1539.6" "1502.6" "1713.9" "2174.7" "2059.1" "2134.0" "2404.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "91.865" "11" "20" "21" "20" "2240" "243.7" "7.88" "78.64" "20" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "1.045" "0.990" "1.006" "1.002" "0.979" "0.982" "0.977" "1.004" "0.972" "2573.7" "2690.4" "2547.5" "2590.1" "2578.4" "2518.6" "2528.0" "2514.8" "2583.7" "2501.0" "" "" "" "" "" "" "" "" "" "" "2282.3" "2228.6" "2222.8" "1937.0" "2150.1" "2313.6" "2136.6" "2078.6" "2369.6" "2501.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "91.843" "41" "13" "23" "13" "337" "38.6" "6.38" "94.14" "13" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "1.036" "1.076" "1.063" "1.147" "1.058" "1.040" "1.059" "1.052" "0.571" "1660.0" "1719.5" "1786.8" "1764.7" "1904.8" "1757.0" "1725.8" "1757.9" "1746.3" "947.1" "" "" "" "" "" "" "" "" "" "" "1472.1" "1424.3" "1559.1" "1319.8" "1588.3" "1614.0" "1458.6" "1453.0" "1601.6" "947.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "91.597" "27" "13" "17" "13" "583" "62.8" "6.44" "66.85" "13" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "Interleukin receptor SHC signaling; RET signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signalling to RAS; Constitutive Signaling by Overexpressed ERBB2; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "65" "0" "1.006" "0.969" "0.984" "1.007" "0.995" "0.955" "0.964" "0.914" "0.657" "2136.1" "2149.2" "2068.9" "2102.2" "2151.3" "2126.1" "2039.6" "2059.6" "1952.3" "1404.4" "" "" "" "" "" "" "" "" "" "" "1894.3" "1780.3" "1805.2" "1572.2" "1793.9" "1953.1" "1723.8" "1702.4" "1790.5" "1404.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "91.557" "43" "7" "19" "7" "215" "24.7" "8.51" "84.16" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "COPI-dependent Golgi-to-ER retrograde traffic; ER-Phagosome pathway; COPII-mediated vesicle transport; Cargo concentration in the ER" "" "4" "0" "1.086" "1.069" "1.079" "1.118" "1.134" "1.091" "1.132" "1.017" "0.496" "2177.9" "2364.7" "2328.9" "2350.1" "2434.6" "2470.7" "2375.2" "2465.0" "2215.9" "1079.7" "" "" "" "" "" "" "" "" "" "" "1931.3" "1958.8" "2032.1" "1757.6" "2030.2" "2269.6" "2007.4" "2037.5" "2032.3" "1079.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3208052669097016746" "False" "High" "IsMasterProtein" "P51608" "Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2 PE=1 SV=1" "0.000" "False" "91.367" "33" "14" "18" "14" "486" "52.4" "9.95" "68.21" "14" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429" "4204" "ENSG00000169057" "MECP2" "hsa:4204; O15233; P51608; Q6QHH9; Q7Z384" "" "Ectoderm differentiation; MECP2 and associated Rett syndrome; Lung fibrosis; Rett syndrome; Transcription co-factors SKI and SKIL protein partners; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Neurogenesis regulation in the olfactory epithelium; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "10" "0" "0.975" "0.952" "0.969" "0.961" "0.950" "0.983" "0.984" "0.972" "0.629" "1970.8" "1922.0" "1875.5" "1909.2" "1893.7" "1871.8" "1937.5" "1938.5" "1915.6" "1239.4" "" "" "" "" "" "" "" "" "" "" "1747.6" "1592.1" "1636.4" "1427.9" "1579.1" "1719.4" "1637.5" "1602.3" "1756.9" "1239.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "91.360" "36" "8" "17" "8" "336" "35.3" "8.13" "85.27" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "1.039" "1.016" "1.051" "1.065" "1.095" "1.023" "1.084" "1.021" "0.408" "1725.1" "1792.9" "1752.7" "1813.8" "1836.6" "1888.7" "1764.2" "1870.6" "1762.0" "703.4" "" "" "" "" "" "" "" "" "" "" "1529.8" "1485.1" "1529.3" "1356.5" "1531.4" "1735.0" "1491.0" "1546.2" "1616.0" "703.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "91.331" "44" "15" "32" "15" "309" "35.8" "6.80" "120.20" "15" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "Vitamin B5 (pantothenate) metabolism" "" "1" "0" "1.058" "1.025" "1.046" "1.074" "1.020" "1.009" "1.008" "0.979" "0.826" "3177.3" "3362.3" "3257.0" "3322.5" "3413.4" "3241.2" "3206.5" "3203.4" "3110.9" "2623.3" "" "" "" "" "" "" "" "" "" "" "2817.6" "2785.2" "2841.9" "2484.8" "2846.3" "2977.4" "2710.0" "2647.8" "2853.1" "2623.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "91.322" "37" "19" "38" "14" "572" "61.6" "8.38" "129.64" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "1.005" "0.960" "0.976" "0.944" "0.937" "1.014" "0.938" "1.024" "2.222" "1570.9" "1578.1" "1507.4" "1533.9" "1483.4" "1471.3" "1593.2" "1473.6" "1608.8" "3491.0" "" "" "" "" "" "" "" "" "" "" "1393.1" "1307.3" "1315.3" "1147.2" "1236.9" "1351.6" "1346.5" "1218.1" "1475.4" "3491.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6698557715673705148" "False" "High" "IsMasterProtein" "Q6P3W7" "SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1" "0.000" "False" "91.306" "21" "16" "21" "16" "929" "103.6" "8.22" "83.55" "16" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "55681" "ENSG00000136021" "SCYL2" "A8KAB5; hsa:55681; Q6P3W7; Q96EF4; Q96ST4; Q9H7V5; Q9NVH3; Q9P2I7" "" "" "0" "0" "1.050" "1.023" "1.061" "1.040" "0.978" "1.057" "1.030" "0.961" "0.718" "1444.8" "1516.7" "1478.7" "1532.7" "1503.3" "1413.2" "1527.9" "1488.1" "1388.9" "1036.9" "" "" "" "" "" "" "" "" "" "" "1281.2" "1256.4" "1290.3" "1146.2" "1253.6" "1298.2" "1291.3" "1230.0" "1273.8" "1036.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "91.285" "28" "11" "22" "11" "403" "44.0" "7.23" "74.58" "11" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.983" "0.988" "1.026" "1.050" "1.040" "1.007" "1.027" "0.946" "0.528" "2317.6" "2278.5" "2290.0" "2377.6" "2432.6" "2409.8" "2334.5" "2381.1" "2193.4" "1223.0" "" "" "" "" "" "" "" "" "" "" "2055.2" "1887.4" "1998.2" "1778.1" "2028.5" "2213.7" "1973.0" "1968.2" "2011.6" "1223.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "91.266" "18" "11" "28" "11" "547" "59.0" "6.89" "105.39" "11" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "10" "0" "0.997" "1.025" "1.042" "0.996" "1.006" "1.025" "1.047" "1.033" "0.479" "3989.3" "3975.5" "4088.7" "4155.0" "3973.1" "4014.3" "4090.1" "4175.9" "4122.7" "1909.0" "" "" "" "" "" "" "" "" "" "" "3537.6" "3293.1" "3567.6" "3107.4" "3313.0" "3687.6" "3456.8" "3451.7" "3781.0" "1909.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "91.265" "41" "10" "15" "10" "308" "33.9" "4.84" "67.09" "10" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "NoRC negatively regulates rRNA expression" "" "1" "0" "0.995" "0.994" "0.984" "0.949" "0.893" "0.855" "0.927" "0.953" "0.655" "2044.3" "2034.7" "2032.7" "2010.7" "1939.5" "1824.6" "1748.5" "1896.0" "1947.2" "1339.6" "" "" "" "" "" "" "" "" "" "" "1812.8" "1685.4" "1773.6" "1503.7" "1617.3" "1676.1" "1477.7" "1567.2" "1785.8" "1339.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3980314117452886183" "False" "High" "IsMasterProtein" "P62979" "Ubiquitin-ribosomal protein eS31 fusion protein OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2" "0.000" "False" "91.258" "54" "10" "243" "1" "156" "18.0" "9.64" "779.36" "10" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01599" "6233" "ENSG00000143947" "RPS27A" "hsa:6233; P02248; P02249; P02250; P14798; P62979; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BQ77; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Cargo recognition for clathrin-mediated endocytosis; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; Signaling by ALK fusions and activated point mutants; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Interferon alpha/beta signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "Cytoplasmic ribosomal proteins" "203" "8" "0.996" "0.992" "0.998" "1.000" "1.127" "0.989" "1.010" "1.028" "0.679" "19894.4" "19813.4" "19732.0" "19861.3" "19884.9" "22421.0" "19683.6" "20096.5" "20455.4" "13513.7" "" "" "" "" "" "" "" "" "" "" "17642.0" "16412.4" "17217.2" "14853.6" "16581.3" "20596.2" "16635.8" "16611.2" "18760.4" "13513.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "91.216" "57" "8" "55" "3" "147" "16.5" "7.93" "195.12" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "19" "7" "1.025" "1.002" "1.001" "1.020" "1.034" "1.024" "1.017" "1.025" "0.666" "3100.7" "3178.6" "3107.7" "3103.8" "3163.4" "3206.8" "3175.4" "3152.6" "3178.4" "2065.3" "" "" "" "" "" "" "" "" "" "" "2749.6" "2633.0" "2711.6" "2321.2" "2637.8" "2945.8" "2683.7" "2605.8" "2915.0" "2065.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "91.121" "14" "9" "22" "8" "721" "82.1" "6.95" "99.58" "9" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.897" "0.824" "0.859" "0.804" "0.792" "0.652" "0.762" "0.764" "0.447" "2231.6" "2001.4" "1838.0" "1916.9" "1794.4" "1767.0" "1455.6" "1700.1" "1706.0" "997.2" "" "" "" "" "" "" "" "" "" "" "1978.9" "1657.8" "1603.8" "1433.6" "1496.3" "1623.2" "1230.2" "1405.2" "1564.6" "997.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641944312381893453" "False" "High" "IsMasterProtein" "Q8IYB7" "DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4" "0.000" "False" "91.050" "26" "21" "24" "21" "885" "99.2" "6.10" "86.85" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17216, Pf17849, Pf17877" "129563" "ENSG00000144535" "DIS3L2" "hsa:129563; Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8IYB7; Q8N9K9" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "1" "0" "1.021" "1.012" "0.988" "0.992" "1.043" "0.975" "0.969" "0.980" "1.207" "2343.3" "2393.6" "2371.8" "2314.7" "2324.3" "2443.0" "2285.3" "2269.9" "2297.1" "2829.2" "" "" "" "" "" "" "" "" "" "" "2078.0" "1982.7" "2069.5" "1731.1" "1938.1" "2244.2" "1931.4" "1876.2" "2106.8" "2829.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.000" "False" "90.994" "38" "14" "27" "14" "415" "46.9" "6.21" "89.80" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "Metalloprotease DUBs" "" "1" "0" "1.006" "1.025" "0.984" "1.012" "1.050" "0.994" "1.032" "1.040" "0.567" "3081.3" "3099.2" "3157.4" "3032.1" "3119.4" "3235.2" "3061.7" "3180.9" "3203.7" "1747.2" "" "" "" "" "" "" "" "" "" "" "2732.4" "2567.2" "2754.9" "2267.6" "2601.2" "2971.9" "2587.7" "2629.2" "2938.3" "1747.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "90.987" "19" "16" "21" "16" "879" "99.3" "6.35" "79.55" "16" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "Regulation of pyruvate dehydrogenase (PDH) complex" "" "1" "0" "1.006" "0.996" "1.026" "1.018" "1.085" "1.052" "1.022" "0.909" "0.475" "2609.6" "2625.4" "2598.3" "2678.3" "2657.3" "2830.7" "2744.3" "2668.3" "2372.1" "1238.7" "" "" "" "" "" "" "" "" "" "" "2314.1" "2174.8" "2267.2" "2003.0" "2215.8" "2600.3" "2319.4" "2205.5" "2175.6" "1238.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "90.913" "36" "10" "19" "10" "316" "36.0" "5.92" "76.69" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "1.065" "0.981" "1.124" "1.095" "1.059" "1.080" "1.062" "0.935" "0.621" "1459.8" "1554.0" "1432.1" "1641.5" "1598.5" "1546.3" "1577.3" "1550.9" "1365.3" "906.2" "" "" "" "" "" "" "" "" "" "" "1294.5" "1287.3" "1249.6" "1227.7" "1333.0" "1420.4" "1333.1" "1281.9" "1252.2" "906.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "90.902" "32" "12" "18" "12" "491" "52.4" "5.10" "78.54" "12" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "mRNA Splicing - Major Pathway" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "4" "0" "0.950" "0.995" "0.946" "0.975" "0.962" "0.976" "0.947" "0.965" "0.615" "2457.0" "2334.0" "2445.3" "2324.2" "2395.8" "2364.8" "2396.9" "2326.1" "2371.1" "1510.0" "" "" "" "" "" "" "" "" "" "" "2178.8" "1933.4" "2133.7" "1738.2" "1997.8" "2172.3" "2025.8" "1922.7" "2174.6" "1510.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "90.885" "48" "15" "23" "14" "370" "41.5" "8.18" "93.42" "15" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "1.032" "1.001" "1.091" "1.063" "1.060" "1.070" "1.096" "0.959" "0.525" "1868.6" "1928.9" "1871.2" "2037.9" "1986.5" "1980.3" "2000.3" "2047.1" "1792.7" "981.7" "" "" "" "" "" "" "" "" "" "" "1657.0" "1597.8" "1632.7" "1524.1" "1656.5" "1819.2" "1690.6" "1692.1" "1644.1" "981.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "90.780" "35" "12" "23" "8" "386" "42.9" "7.74" "95.63" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "FGFR2 alternative splicing" "" "1" "2" "1.004" "0.938" "0.936" "0.881" "0.855" "0.878" "0.961" "0.961" "0.565" "2275.5" "2285.6" "2134.0" "2128.8" "2003.7" "1944.5" "1998.8" "2187.7" "2185.7" "1286.6" "" "" "" "" "" "" "" "" "" "" "2017.9" "1893.3" "1862.0" "1592.1" "1670.8" "1786.2" "1689.3" "1808.3" "2004.6" "1286.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "90.455" "50" "8" "24" "8" "204" "22.6" "9.45" "100.35" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "" "TAR syndrome" "1" "0" "0.942" "0.974" "0.968" "0.943" "0.957" "0.936" "0.961" "0.959" "0.471" "3370.5" "3174.5" "3281.4" "3261.2" "3179.0" "3224.1" "3154.4" "3240.7" "3233.0" "1587.4" "" "" "" "" "" "" "" "" "" "" "2988.9" "2629.6" "2863.2" "2438.9" "2650.8" "2961.7" "2666.0" "2678.7" "2965.1" "1587.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "90.454" "34" "5" "21" "5" "237" "26.2" "4.11" "93.72" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "snRNP Assembly" "" "1" "0" "1.140" "0.977" "1.182" "1.121" "0.997" "1.191" "1.122" "1.038" "0.656" "1090.3" "1243.1" "1064.7" "1288.5" "1221.9" "1087.2" "1298.1" "1223.0" "1131.7" "715.1" "" "" "" "" "" "" "" "" "" "" "966.8" "1029.7" "929.0" "963.7" "1018.9" "998.7" "1097.1" "1010.9" "1038.0" "715.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "90.449" "62" "13" "102" "13" "149" "17.3" "5.97" "318.20" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Nuclear signaling by ERBB4" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "7" "0" "0.978" "0.981" "0.962" "1.021" "0.922" "0.921" "1.042" "1.064" "0.476" "11393.4" "11147.6" "11176.1" "10960.0" "11631.1" "10499.7" "10488.7" "11867.6" "12123.1" "5424.3" "" "" "" "" "" "" "" "" "" "" "10103.4" "9234.1" "9751.7" "8196.7" "9698.7" "9645.2" "8864.6" "9809.4" "11118.5" "5424.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4237010065397601257" "False" "High" "IsMasterProtein" "A0A2R8YFR7" "DH domain-containing protein OS=Homo sapiens OX=9606 GN=LOC107987545 PE=4 SV=1" "0.000" "False" "90.405" "12" "12" "20" "5" "1487" "164.0" "5.60" "82.31" "12" "signal transduction" "nucleus;other cell component" "enzyme regulator activity" "Pf00621, Pf15441" "" "" "" "" "" "" "0" "6" "1.004" "0.953" "1.062" "0.959" "0.994" "1.043" "0.992" "0.991" "1.218" "1244.9" "1250.5" "1186.5" "1321.5" "1194.2" "1237.4" "1298.0" "1235.5" "1234.2" "1516.2" "" "" "" "" "" "" "" "" "" "" "1103.9" "1035.8" "1035.3" "988.3" "995.8" "1136.7" "1097.0" "1021.2" "1131.9" "1516.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "90.369" "54" "13" "34" "13" "222" "25.1" "4.70" "140.14" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "0.945" "0.935" "0.980" "0.926" "0.991" "0.906" "0.934" "0.924" "0.573" "5198.2" "4911.7" "4860.0" "5093.7" "4812.6" "5149.0" "4708.8" "4857.6" "4800.6" "2976.2" "" "" "" "" "" "" "" "" "" "" "4609.7" "4068.6" "4240.6" "3809.4" "4013.1" "4729.9" "3979.7" "4015.2" "4402.8" "2976.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179525910857735181" "False" "High" "IsMasterProtein" "P49590" "Histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" "0.000" "False" "90.209" "32" "15" "25" "7" "506" "56.9" "8.24" "83.17" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf03129, Pf13393" "23438" "ENSG00000112855" "HARS2" "B4DDY8; hsa:23438; P49590" "Mitochondrial tRNA aminoacylation" "Primary ovarian insufficiency" "2" "0" "1.059" "1.082" "1.130" "1.140" "1.105" "1.190" "1.197" "1.166" "0.567" "998.1" "1057.4" "1079.5" "1128.1" "1137.8" "1102.5" "1187.3" "1194.3" "1163.8" "566.2" "" "" "" "" "" "" "" "" "" "" "885.1" "875.9" "941.9" "843.6" "948.8" "1012.8" "1003.4" "987.2" "1067.4" "566.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "90.093" "36" "10" "18" "10" "359" "39.3" "5.21" "73.16" "10" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "1.015" "0.939" "0.985" "0.950" "0.899" "0.971" "0.797" "0.810" "2.121" "910.9" "924.4" "855.4" "897.0" "865.7" "818.6" "884.6" "725.8" "738.0" "1932.4" "" "" "" "" "" "" "" "" "" "" "807.8" "765.8" "746.3" "670.8" "721.9" "752.0" "747.7" "599.9" "676.9" "1932.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "90.070" "45" "14" "27" "14" "312" "33.6" "5.62" "99.07" "14" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "Cytosolic iron-sulfur cluster assembly" "" "1" "0" "0.991" "1.030" "0.973" "0.972" "1.018" "0.977" "0.986" "0.997" "0.971" "4026.1" "3991.8" "4148.4" "3917.5" "3911.7" "4098.0" "3934.9" "3969.2" "4012.7" "3909.0" "" "" "" "" "" "" "" "" "" "" "3570.3" "3306.6" "3619.7" "2929.8" "3261.8" "3764.5" "3325.7" "3280.8" "3680.2" "3909.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "90.041" "59" "10" "55" "10" "177" "19.5" "7.71" "181.48" "10" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "0.924" "0.954" "0.901" "0.868" "1.013" "0.860" "0.988" "0.975" "0.507" "4403.6" "4069.5" "4201.9" "3965.5" "3823.2" "4461.6" "3785.7" "4350.6" "4294.8" "2230.8" "" "" "" "" "" "" "" "" "" "" "3905.0" "3371.0" "3666.4" "2965.6" "3188.0" "4098.5" "3199.5" "3596.0" "3938.9" "2230.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "89.984" "32" "14" "28" "14" "501" "58.8" "5.38" "99.98" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "mRNA Splicing - Major Pathway" "Exercise-induced circadian regulation; mRNA processing" "3" "0" "1.110" "0.982" "1.085" "1.008" "1.007" "1.027" "0.904" "0.913" "2.017" "1209.3" "1342.7" "1187.1" "1312.0" "1218.8" "1217.6" "1242.3" "1093.4" "1104.6" "2438.8" "" "" "" "" "" "" "" "" "" "" "1072.4" "1112.2" "1035.8" "981.2" "1016.3" "1118.5" "1050.0" "903.8" "1013.0" "2438.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "89.971" "32" "13" "25" "13" "485" "53.4" "7.58" "97.72" "13" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "" "Ciliary landscape" "1" "0" "1.011" "0.942" "0.984" "0.960" "0.912" "0.943" "0.948" "0.917" "0.702" "2702.6" "2731.0" "2547.1" "2658.9" "2594.0" "2465.2" "2548.6" "2562.9" "2478.6" "1897.4" "" "" "" "" "" "" "" "" "" "" "2396.6" "2262.2" "2222.5" "1988.5" "2163.0" "2264.6" "2154.0" "2118.4" "2273.2" "1897.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832303337719112949" "False" "High" "IsMasterProtein" "Q15154" "Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1 PE=1 SV=6" "0.000" "False" "89.895" "11" "21" "24" "20" "2024" "228.4" "5.02" "83.90" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15717" "5108" "ENSG00000078674" "PCM1" "A6NNN6; B4DYD5; E7ETA6; E7EV56; hsa:5108; Q15154; Q58F13; Q6P1K7; Q8NB85; Q9BWC1; Q9H4A2" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Prader-Willi and Angelman syndrome; Joubert syndrome" "9" "0" "0.977" "1.035" "1.024" "0.969" "1.002" "0.961" "0.975" "1.029" "0.804" "2439.5" "2383.1" "2524.7" "2498.4" "2364.2" "2445.2" "2343.4" "2378.5" "2510.2" "1960.4" "" "" "" "" "" "" "" "" "" "" "2163.3" "1974.0" "2202.9" "1868.4" "1971.4" "2246.2" "1980.5" "1966.0" "2302.2" "1960.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "89.754" "3" "5" "45" "5" "2078" "205.3" "9.58" "184.52" "5" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "0.999" "1.013" "0.986" "0.986" "1.029" "0.997" "0.992" "0.986" "0.553" "5440.9" "5433.8" "5512.8" "5364.5" "5364.9" "5599.0" "5422.2" "5397.5" "5367.1" "3007.7" "" "" "" "" "" "" "" "" "" "" "4824.9" "4501.1" "4810.2" "4011.9" "4473.6" "5143.3" "4582.6" "4461.4" "4922.4" "3007.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "89.732" "37" "12" "34" "12" "369" "39.1" "6.30" "123.60" "12" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "1.070" "1.031" "1.105" "1.103" "1.049" "1.039" "1.083" "0.939" "0.567" "3408.6" "3647.4" "3514.7" "3767.1" "3761.2" "3575.7" "3541.6" "3692.9" "3201.3" "1933.4" "" "" "" "" "" "" "" "" "" "" "3022.7" "3021.3" "3066.7" "2817.3" "3136.4" "3284.7" "2993.2" "3052.5" "2936.0" "1933.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "89.710" "67" "11" "23" "11" "204" "23.4" "5.49" "82.47" "11" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "1.026" "0.959" "1.030" "0.986" "0.967" "0.998" "0.998" "0.974" "0.565" "1998.0" "2049.5" "1916.5" "2058.4" "1970.0" "1932.7" "1994.8" "1993.4" "1946.5" "1128.1" "" "" "" "" "" "" "" "" "" "" "1771.8" "1697.7" "1672.2" "1539.4" "1642.7" "1775.4" "1686.0" "1647.7" "1785.2" "1128.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "High" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.000" "False" "89.661" "30" "16" "22" "16" "608" "68.1" "6.38" "89.49" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "" "3" "0" "1.017" "1.072" "0.981" "1.067" "1.064" "1.033" "1.077" "1.075" "0.901" "2756.5" "2802.6" "2955.4" "2703.0" "2940.2" "2933.0" "2847.8" "2969.2" "2963.1" "2482.8" "" "" "" "" "" "" "" "" "" "" "2444.4" "2321.5" "2578.7" "2021.5" "2451.7" "2694.3" "2406.8" "2454.3" "2717.6" "2482.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.000" "False" "89.533" "22" "15" "18" "13" "815" "92.5" "5.31" "73.42" "15" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "0" "1.120" "1.114" "1.112" "1.136" "1.056" "1.037" "1.099" "1.006" "1.605" "1126.7" "1261.9" "1255.2" "1253.0" "1280.5" "1190.3" "1168.1" "1237.8" "1133.3" "1808.3" "" "" "" "" "" "" "" "" "" "" "999.2" "1045.3" "1095.2" "937.1" "1067.7" "1093.5" "987.2" "1023.1" "1039.4" "1808.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "89.528" "36" "9" "28" "9" "255" "28.4" "8.62" "99.41" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "mRNA processing" "3" "0" "1.025" "1.006" "1.032" "1.011" "1.007" "1.026" "0.995" "0.990" "0.591" "2831.8" "2902.2" "2849.2" "2921.0" "2863.1" "2852.5" "2906.6" "2817.6" "2802.8" "1674.1" "" "" "" "" "" "" "" "" "" "" "2511.2" "2404.0" "2486.0" "2184.5" "2387.4" "2620.4" "2456.5" "2329.0" "2570.5" "1674.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "89.517" "23" "11" "19" "11" "721" "80.3" "5.08" "83.95" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Recycling of eIF2:GDP" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "5" "0" "0.971" "0.959" "1.030" "1.055" "1.027" "1.241" "1.259" "1.161" "1.157" "1857.0" "1804.0" "1780.9" "1912.9" "1959.4" "1907.1" "2303.9" "2337.2" "2156.4" "2148.0" "" "" "" "" "" "" "" "" "" "" "1646.8" "1494.3" "1553.9" "1430.6" "1633.8" "1751.9" "1947.2" "1931.9" "1977.7" "2148.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "89.405" "38" "11" "38" "10" "198" "21.9" "5.97" "140.84" "11" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "6" "0" "0.991" "1.089" "0.977" "0.989" "1.006" "1.033" "1.046" "0.990" "0.558" "3633.2" "3601.6" "3957.7" "3550.8" "3594.4" "3656.1" "3752.6" "3799.3" "3597.0" "2026.4" "" "" "" "" "" "" "" "" "" "" "3221.8" "2983.4" "3453.2" "2655.5" "2997.2" "3358.5" "3171.5" "3140.4" "3298.9" "2026.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "89.371" "30" "18" "29" "11" "614" "69.1" "8.92" "93.71" "18" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; SUMOylation of transcription cofactors; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "Ciliary landscape" "6" "0" "1.066" "1.029" "1.017" "0.945" "1.053" "0.716" "0.367" "0.739" "8.091" "725.1" "773.2" "746.1" "737.4" "685.0" "763.2" "518.9" "266.3" "536.1" "5867.1" "" "" "" "" "" "" "" "" "" "" "643.0" "640.5" "651.0" "551.5" "571.2" "701.1" "438.6" "220.1" "491.6" "5867.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "89.230" "27" "12" "16" "12" "594" "66.5" "5.59" "72.08" "12" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "" "6" "0" "1.062" "1.019" "1.016" "1.033" "1.113" "1.001" "0.988" "1.033" "0.939" "1487.9" "1579.9" "1516.0" "1512.2" "1537.0" "1656.6" "1489.4" "1469.4" "1536.7" "1397.3" "" "" "" "" "" "" "" "" "" "" "1319.4" "1308.7" "1322.8" "1130.9" "1281.6" "1521.7" "1258.8" "1214.6" "1409.3" "1397.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "89.158" "38" "9" "31" "9" "277" "29.9" "7.68" "116.39" "9" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "Ub-specific processing proteases; Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "1.010" "1.026" "1.004" "1.085" "0.993" "1.030" "1.050" "1.097" "0.490" "3668.9" "3705.8" "3765.9" "3681.9" "3980.5" "3644.8" "3778.6" "3852.3" "4024.2" "1798.5" "" "" "" "" "" "" "" "" "" "" "3253.5" "3069.7" "3286.0" "2753.6" "3319.2" "3348.2" "3193.5" "3184.2" "3690.7" "1798.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "89.083" "24" "11" "18" "6" "524" "59.0" "5.91" "65.12" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "16" "3" "1.040" "1.008" "1.028" "1.051" "1.001" "1.033" "1.005" "0.955" "0.818" "1047.7" "1089.7" "1055.9" "1077.1" "1101.1" "1048.7" "1082.6" "1053.1" "1000.5" "857.4" "" "" "" "" "" "" "" "" "" "" "929.1" "902.7" "921.3" "805.5" "918.2" "963.3" "915.0" "870.5" "917.6" "857.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "88.883" "37" "12" "23" "7" "420" "46.7" "8.78" "101.92" "12" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Regulation of HSF1-mediated heat shock response; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "95" "6" "0.998" "1.068" "1.012" "1.060" "1.101" "0.973" "1.035" "0.964" "0.814" "3763.9" "3754.5" "4018.4" "3810.4" "3990.9" "4142.6" "3663.1" "3896.0" "3627.7" "3063.2" "" "" "" "" "" "" "" "" "" "" "3337.7" "3110.1" "3506.3" "2849.7" "3327.9" "3805.4" "3095.9" "3220.3" "3327.1" "3063.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "88.875" "16" "14" "19" "14" "1118" "121.8" "8.88" "75.12" "14" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.909" "0.914" "0.921" "0.886" "0.847" "0.857" "0.895" "1.019" "1.729" "1591.9" "1447.8" "1455.5" "1465.9" "1409.7" "1348.9" "1364.0" "1424.6" "1621.4" "2752.6" "" "" "" "" "" "" "" "" "" "" "1411.6" "1199.3" "1270.0" "1096.3" "1175.5" "1239.1" "1152.8" "1177.5" "1487.1" "2752.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "88.867" "56" "10" "29" "7" "201" "23.0" "8.29" "103.50" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "" "3" "0" "0.989" "0.999" "0.947" "0.997" "1.056" "0.935" "0.955" "0.966" "0.512" "1513.7" "1497.1" "1511.5" "1433.8" "1509.5" "1598.3" "1415.8" "1446.0" "1461.8" "775.2" "" "" "" "" "" "" "" "" "" "" "1342.3" "1240.1" "1318.9" "1072.3" "1258.7" "1468.2" "1196.6" "1195.2" "1340.6" "775.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "88.854" "56" "10" "26" "10" "225" "25.0" "5.69" "101.45" "10" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "6" "0" "1.042" "1.008" "1.090" "1.091" "1.044" "1.093" "1.091" "1.004" "0.551" "2088.5" "2176.1" "2104.6" "2277.0" "2279.1" "2179.7" "2281.9" "2278.3" "2096.7" "1151.3" "" "" "" "" "" "" "" "" "" "" "1852.0" "1802.6" "1836.4" "1702.9" "1900.4" "2002.3" "1928.5" "1883.2" "1923.0" "1151.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "88.676" "41" "8" "30" "8" "196" "22.2" "5.57" "115.52" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "1.044" "1.075" "1.107" "1.123" "1.151" "1.234" "1.328" "1.295" "0.742" "2064.3" "2155.1" "2219.1" "2285.4" "2318.1" "2376.2" "2547.4" "2742.0" "2672.6" "1531.5" "" "" "" "" "" "" "" "" "" "" "1830.6" "1785.1" "1936.2" "1709.2" "1933.0" "2182.8" "2152.9" "2266.4" "2451.2" "1531.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "88.630" "42" "7" "57" "7" "172" "19.6" "4.93" "226.77" "7" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "0.956" "0.975" "0.930" "0.943" "0.994" "0.883" "0.932" "0.902" "0.624" "7173.0" "6858.2" "6992.8" "6669.7" "6764.2" "7128.5" "6336.2" "6686.8" "6466.7" "4475.1" "" "" "" "" "" "" "" "" "" "" "6360.9" "5681.0" "6101.6" "4988.1" "5640.4" "6548.3" "5355.1" "5527.1" "5930.9" "4475.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.000" "False" "88.623" "55" "12" "25" "12" "274" "28.6" "7.72" "94.39" "12" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "Glutamate and glutamine metabolism" "" "1" "0" "1.044" "1.021" "1.110" "1.093" "1.047" "1.086" "1.048" "1.006" "0.664" "1383.1" "1443.3" "1412.8" "1534.9" "1512.2" "1448.1" "1501.5" "1449.1" "1391.2" "918.1" "" "" "" "" "" "" "" "" "" "" "1226.5" "1195.6" "1232.7" "1147.9" "1261.0" "1330.2" "1269.0" "1197.8" "1276.0" "918.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "88.605" "22" "14" "25" "3" "611" "66.7" "7.36" "89.63" "14" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "Bicarbonate transporters" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "4" "0" "1.026" "0.968" "1.112" "1.015" "1.005" "1.019" "0.919" "0.848" "0.521" "280.1" "287.3" "271.2" "311.5" "284.2" "281.5" "285.5" "257.5" "237.5" "146.1" "" "" "" "" "" "" "" "" "" "" "248.4" "238.0" "236.6" "233.0" "237.0" "258.6" "241.3" "212.8" "217.8" "146.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.000" "False" "88.592" "34" "16" "18" "16" "534" "60.6" "7.31" "70.62" "16" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "10" "0" "1.033" "1.042" "1.064" "1.071" "1.031" "1.054" "1.070" "1.046" "1.104" "2199.9" "2272.7" "2292.6" "2341.3" "2356.6" "2267.8" "2319.3" "2353.2" "2300.7" "2429.7" "" "" "" "" "" "" "" "" "" "" "1950.9" "1882.6" "2000.4" "1751.0" "1965.0" "2083.3" "1960.2" "1945.1" "2110.1" "2429.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "High" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.000" "False" "88.574" "49" "9" "15" "9" "305" "33.6" "5.47" "71.63" "9" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease" "" "5" "0" "1.071" "1.037" "1.090" "1.079" "1.092" "1.128" "1.183" "1.039" "0.883" "1348.5" "1444.0" "1397.9" "1470.0" "1455.0" "1472.7" "1521.2" "1595.5" "1401.5" "1191.0" "" "" "" "" "" "" "" "" "" "" "1195.8" "1196.1" "1219.8" "1099.3" "1213.2" "1352.9" "1285.7" "1318.8" "1285.4" "1191.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "88.539" "23" "17" "23" "16" "952" "102.9" "7.58" "79.81" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "SUMOylation of DNA damage response and repair proteins; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "13" "0" "1.013" "0.944" "1.052" "1.002" "0.979" "0.982" "0.954" "0.909" "0.756" "2018.7" "2044.9" "1906.2" "2122.9" "2022.8" "1976.3" "1983.4" "1925.0" "1834.0" "1526.9" "" "" "" "" "" "" "" "" "" "" "1790.2" "1693.9" "1663.2" "1587.6" "1686.8" "1815.4" "1676.3" "1591.1" "1682.1" "1526.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "88.513" "37" "15" "40" "15" "503" "51.2" "11.47" "140.50" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "" "5" "0" "1.009" "1.005" "1.037" "1.008" "1.016" "0.919" "0.961" "0.976" "0.717" "3604.4" "3636.0" "3623.8" "3736.0" "3634.5" "3663.4" "3312.2" "3462.9" "3519.0" "2585.6" "" "" "" "" "" "" "" "" "" "" "3196.3" "3011.9" "3162.0" "2794.0" "3030.7" "3365.3" "2799.4" "2862.3" "3227.4" "2585.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "88.490" "33" "16" "28" "16" "504" "56.2" "5.48" "111.81" "16" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "61" "0" "1.090" "1.035" "1.124" "1.134" "1.032" "1.112" "1.012" "0.992" "1.324" "2352.1" "2564.8" "2434.2" "2643.3" "2667.4" "2427.6" "2614.6" "2380.6" "2332.2" "3114.7" "" "" "" "" "" "" "" "" "" "" "2085.8" "2124.6" "2123.9" "1976.8" "2224.3" "2230.1" "2209.8" "1967.7" "2138.9" "3114.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "88.475" "20" "18" "24" "18" "963" "108.1" "6.44" "83.60" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.055" "1.024" "1.136" "1.071" "1.064" "1.023" "1.017" "0.985" "0.576" "1203.8" "1269.7" "1232.4" "1367.2" "1289.5" "1280.2" "1231.4" "1224.5" "1185.7" "693.7" "" "" "" "" "" "" "" "" "" "" "1067.5" "1051.8" "1075.3" "1022.5" "1075.3" "1176.0" "1040.7" "1012.2" "1087.4" "693.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1403066018753267541" "False" "High" "IsMasterProtein" "Q96RU3" "Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2" "0.000" "False" "88.471" "26" "14" "20" "14" "617" "71.3" "5.72" "77.95" "14" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "23048" "ENSG00000187239" "FNBP1" "B7ZL12; E9PGQ4; hsa:23048; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q96RU3; Q9H8H8; Q9NWD1" "Clathrin-mediated endocytosis; CDC42 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "" "5" "0" "0.991" "0.957" "1.004" "1.004" "0.930" "0.966" "0.583" "0.957" "7.281" "1373.7" "1360.6" "1315.2" "1379.7" "1379.6" "1277.4" "1327.0" "800.7" "1313.9" "10001.4" "" "" "" "" "" "" "" "" "" "" "1218.2" "1127.1" "1147.5" "1031.8" "1150.4" "1173.4" "1121.6" "661.9" "1205.1" "10001.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-599104977835536313" "False" "High" "IsMasterProtein" "P28799" "Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2" "0.000" "False" "88.372" "27" "13" "22" "13" "593" "63.5" "6.83" "79.71" "13" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00396" "2896" "ENSG00000030582" "GRN" "D3DX55; hsa:2896; P23781; P23782; P23783; P23784; P28799; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0" "Neutrophil degranulation" "IL-18 signaling pathway" "2" "0" "0.982" "0.967" "0.942" "0.999" "1.046" "0.948" "0.986" "1.011" "0.575" "1936.4" "1901.2" "1873.4" "1824.4" "1934.0" "2024.9" "1836.2" "1909.3" "1957.7" "1112.9" "" "" "" "" "" "" "" "" "" "" "1717.1" "1574.9" "1634.6" "1364.4" "1612.7" "1860.1" "1551.9" "1578.2" "1795.5" "1112.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.000" "False" "88.329" "57" "4" "28" "2" "89" "10.4" "7.40" "134.35" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "Neutrophil degranulation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "28" "2" "0.966" "1.007" "0.959" "1.019" "1.035" "1.018" "1.041" "1.112" "1.250" "2713.6" "2621.2" "2731.3" "2602.1" "2764.6" "2807.6" "2762.3" "2824.3" "3017.3" "3392.6" "" "" "" "" "" "" "" "" "" "" "2406.3" "2171.3" "2383.2" "1946.0" "2305.3" "2579.1" "2334.6" "2334.5" "2767.3" "3392.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "88.232" "59" "9" "25" "6" "215" "23.7" "8.13" "104.11" "9" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "9" "0" "1.096" "1.078" "1.103" "1.102" "1.072" "1.080" "1.086" "1.049" "0.579" "1200.3" "1316.1" "1294.4" "1323.8" "1322.8" "1287.1" "1296.1" "1303.5" "1259.7" "694.6" "" "" "" "" "" "" "" "" "" "" "1064.4" "1090.2" "1129.5" "990.0" "1103.1" "1182.4" "1095.4" "1077.4" "1155.3" "694.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "88.166" "33" "9" "16" "9" "285" "31.6" "5.31" "72.44" "9" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.144" "0.985" "1.103" "1.054" "1.047" "0.999" "1.004" "0.985" "0.519" "2392.1" "2736.9" "2357.0" "2639.7" "2520.7" "2504.9" "2390.0" "2402.3" "2356.7" "1242.6" "" "" "" "" "" "" "" "" "" "" "2121.3" "2267.1" "2056.6" "1974.1" "2101.9" "2301.1" "2019.9" "1985.7" "2161.4" "1242.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "88.149" "31" "14" "24" "14" "483" "57.7" "9.48" "92.01" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "" "6" "0" "0.903" "0.903" "0.927" "0.851" "0.961" "0.904" "0.860" "0.910" "1.185" "2226.5" "2011.5" "2009.7" "2064.8" "1893.8" "2138.5" "2013.7" "1915.6" "2027.1" "2637.5" "" "" "" "" "" "" "" "" "" "" "1974.4" "1666.2" "1753.6" "1544.2" "1579.1" "1964.5" "1701.9" "1583.4" "1859.1" "2637.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "88.120" "40" "12" "23" "12" "320" "35.6" "6.13" "89.34" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.988" "1.060" "0.968" "1.003" "1.024" "1.051" "0.998" "1.072" "1.333" "1825.1" "1802.5" "1935.4" "1766.8" "1831.2" "1869.3" "1917.3" "1822.0" "1955.7" "2433.6" "" "" "" "" "" "" "" "" "" "" "1618.5" "1493.1" "1688.8" "1321.3" "1527.0" "1717.2" "1620.5" "1506.0" "1793.7" "2433.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4762125104752177783" "False" "High" "IsMasterProtein" "A0JNW5" "Bridge-like lipid transfer protein family member 3B OS=Homo sapiens OX=9606 GN=BLTP3B PE=1 SV=2" "0.000" "False" "88.073" "14" "18" "20" "17" "1464" "164.1" "6.32" "72.44" "18" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf12624" "23074" "ENSG00000111647" "BLTP3B" "A0JNW5; A0PJE5; hsa:23074; O75183; Q8NDL1; Q96C30; Q9BTS5; Q9H0F1" "RND2 GTPase cycle" "" "1" "0" "0.942" "0.878" "0.928" "0.924" "0.899" "0.927" "0.909" "0.942" "0.740" "2034.8" "1916.9" "1786.3" "1889.1" "1881.0" "1828.6" "1885.6" "1848.8" "1917.1" "1506.3" "" "" "" "" "" "" "" "" "" "" "1804.4" "1587.9" "1558.6" "1412.8" "1568.5" "1679.8" "1593.7" "1528.1" "1758.2" "1506.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "88.017" "34" "9" "24" "9" "334" "36.6" "8.27" "96.31" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Neddylation; RMTs methylate histone arginines; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "Pleural mesothelioma; Kleefstra syndrome" "10" "0" "1.012" "1.001" "0.987" "0.959" "0.988" "0.990" "1.003" "0.959" "0.738" "3043.6" "3080.0" "3047.8" "3004.6" "2920.2" "3005.7" "3011.7" "3052.5" "2919.7" "2247.5" "" "" "" "" "" "" "" "" "" "" "2699.0" "2551.3" "2659.4" "2247.1" "2435.0" "2761.1" "2545.4" "2523.1" "2677.7" "2247.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "87.806" "40" "13" "23" "13" "394" "44.4" "5.40" "88.80" "13" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "" "2" "0" "1.035" "1.013" "0.970" "0.957" "0.985" "0.905" "0.923" "0.957" "0.891" "3055.6" "3163.9" "3094.1" "2963.9" "2924.7" "3009.3" "2764.7" "2820.7" "2923.5" "2722.3" "" "" "" "" "" "" "" "" "" "" "2709.6" "2620.8" "2699.8" "2216.6" "2438.8" "2764.4" "2336.6" "2331.5" "2681.2" "2722.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1983440514863483257" "False" "High" "IsMasterProtein" "O15523" "ATP-dependent RNA helicase DDX3Y OS=Homo sapiens OX=9606 GN=DDX3Y PE=1 SV=2" "0.000" "False" "87.767" "27" "17" "19" "3" "660" "73.1" "7.55" "70.85" "17" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "8653" "ENSG00000067048" "DDX3Y" "B4DK29; B4DXX7; hsa:8653; O15523; Q8IYV7" "" "Novel intracellular components of RIG-I-like receptor pathway" "1" "0" "1.076" "1.086" "1.187" "1.163" "1.090" "1.050" "1.101" "1.147" "2.157" "141.2" "151.9" "153.3" "167.5" "164.2" "153.9" "148.2" "155.4" "161.9" "304.4" "" "" "" "" "" "" "" "" "" "" "125.2" "125.8" "133.8" "125.3" "136.9" "141.4" "125.2" "128.5" "148.5" "304.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "87.734" "40" "12" "18" "12" "354" "38.2" "5.62" "71.00" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "1.003" "1.062" "1.020" "1.063" "1.060" "0.957" "1.019" "0.976" "0.758" "2172.6" "2180.1" "2306.8" "2215.2" "2309.1" "2302.8" "2078.3" "2213.6" "2120.7" "1647.3" "" "" "" "" "" "" "" "" "" "" "1926.6" "1805.9" "2012.8" "1656.6" "1925.5" "2115.3" "1756.5" "1829.7" "1945.0" "1647.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "87.722" "45" "10" "30" "10" "227" "26.2" "8.82" "106.36" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "0.989" "1.097" "0.992" "1.012" "1.049" "1.008" "0.988" "1.093" "0.486" "3367.9" "3331.5" "3693.9" "3339.4" "3409.7" "3531.7" "3394.9" "3327.1" "3682.2" "1638.2" "" "" "" "" "" "" "" "" "" "" "2986.6" "2759.6" "3223.1" "2497.5" "2843.3" "3244.3" "2869.2" "2750.1" "3377.1" "1638.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "87.548" "45" "10" "23" "10" "227" "26.0" "7.91" "96.26" "10" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "1.041" "0.981" "0.922" "0.956" "0.958" "0.883" "0.940" "0.997" "0.808" "3710.2" "3861.4" "3638.0" "3419.4" "3548.8" "3553.6" "3276.1" "3486.3" "3699.2" "2998.9" "" "" "" "" "" "" "" "" "" "" "3290.1" "3198.6" "3174.3" "2557.3" "2959.2" "3264.4" "2768.9" "2881.7" "3392.7" "2998.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "87.443" "38" "9" "20" "8" "346" "36.9" "6.87" "78.61" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "1.101" "0.961" "1.035" "1.034" "1.018" "0.991" "0.408" "0.955" "10.984" "797.9" "878.6" "766.8" "825.5" "824.7" "811.9" "791.0" "325.4" "762.0" "8763.9" "" "" "" "" "" "" "" "" "" "" "707.5" "727.8" "669.1" "617.4" "687.7" "745.8" "668.6" "269.0" "698.9" "8763.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "87.371" "23" "14" "30" "14" "669" "69.4" "9.67" "106.69" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "RUNX2 regulates bone development" "Ciliary landscape" "2" "0" "1.076" "1.052" "0.995" "1.030" "1.033" "1.025" "0.806" "1.035" "4.808" "1535.0" "1650.9" "1614.5" "1526.6" "1580.8" "1585.9" "1573.6" "1237.7" "1588.0" "7379.4" "" "" "" "" "" "" "" "" "" "" "1361.2" "1367.5" "1408.7" "1141.7" "1318.2" "1456.9" "1329.9" "1023.0" "1456.4" "7379.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "87.285" "44" "12" "40" "12" "248" "27.7" "10.36" "147.13" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "0.975" "0.954" "0.965" "1.036" "1.045" "0.946" "0.977" "0.992" "0.495" "4544.6" "4430.8" "4333.7" "4385.1" "4707.0" "4747.4" "4300.6" "4438.2" "4506.4" "2248.2" "" "" "" "" "" "" "" "" "" "" "4030.0" "3670.3" "3781.4" "3279.5" "3925.0" "4361.0" "3634.7" "3668.5" "4133.0" "2248.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "87.178" "53" "12" "24" "12" "247" "28.2" "9.36" "97.09" "12" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "7" "0" "1.003" "0.905" "0.929" "0.939" "0.967" "0.975" "0.948" "0.908" "0.500" "2429.4" "2436.5" "2198.5" "2256.6" "2282.4" "2349.9" "2368.1" "2303.9" "2205.4" "1214.1" "" "" "" "" "" "" "" "" "" "" "2154.3" "2018.3" "1918.3" "1687.7" "1903.2" "2158.6" "2001.4" "1904.4" "2022.6" "1214.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "87.063" "40" "9" "18" "9" "318" "35.5" "8.12" "81.92" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "10" "0" "0.889" "0.929" "0.897" "0.850" "0.868" "0.842" "0.726" "0.841" "3.013" "1898.2" "1687.0" "1764.0" "1703.4" "1613.1" "1648.2" "1598.7" "1378.6" "1596.7" "5719.2" "" "" "" "" "" "" "" "" "" "" "1683.3" "1397.5" "1539.1" "1273.9" "1345.1" "1514.0" "1351.2" "1139.5" "1464.4" "5719.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "86.846" "40" "12" "30" "11" "326" "36.9" "6.46" "100.31" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "30" "0" "0.990" "0.976" "0.970" "0.922" "0.919" "0.921" "0.947" "0.999" "0.704" "3751.3" "3714.8" "3660.3" "3637.1" "3458.4" "3446.8" "3453.9" "3552.3" "3746.3" "2639.8" "" "" "" "" "" "" "" "" "" "" "3326.6" "3077.2" "3193.8" "2720.0" "2883.8" "3166.3" "2919.1" "2936.2" "3435.9" "2639.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "86.706" "46" "16" "22" "15" "364" "40.7" "8.88" "79.18" "16" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Protein hydroxylation" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.035" "1.059" "1.120" "1.056" "1.006" "1.108" "1.075" "0.984" "1.002" "2005.1" "2074.8" "2122.9" "2245.3" "2116.5" "2016.8" "2222.2" "2155.3" "1973.5" "2008.4" "" "" "" "" "" "" "" "" "" "" "1778.0" "1718.7" "1852.3" "1679.2" "1764.9" "1852.7" "1878.1" "1781.5" "1810.0" "2008.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "86.570" "25" "12" "16" "12" "630" "68.0" "5.01" "64.22" "12" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "8" "0" "1.098" "1.040" "1.048" "1.115" "1.071" "1.045" "1.001" "1.240" "0.757" "1183.2" "1299.0" "1230.3" "1240.5" "1319.2" "1267.5" "1236.1" "1184.3" "1467.2" "895.9" "" "" "" "" "" "" "" "" "" "" "1049.3" "1076.0" "1073.5" "927.7" "1100.0" "1164.4" "1044.7" "978.9" "1345.7" "895.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "86.504" "55" "11" "28" "11" "228" "25.7" "7.25" "107.27" "11" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.928" "0.974" "0.944" "0.931" "0.979" "0.979" "0.994" "0.964" "0.629" "1786.4" "1658.6" "1740.6" "1685.9" "1663.6" "1749.7" "1748.3" "1776.0" "1722.9" "1124.0" "" "" "" "" "" "" "" "" "" "" "1584.1" "1373.9" "1518.8" "1260.8" "1387.2" "1607.3" "1477.6" "1468.0" "1580.2" "1124.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137341147702067960" "False" "High" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "0.000" "False" "86.504" "32" "12" "18" "12" "426" "46.6" "8.05" "67.67" "12" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Branched-chain amino acid catabolism" "Valproic acid pathway" "2" "0" "0.969" "0.988" "0.968" "1.021" "1.057" "1.085" "1.058" "1.057" "0.532" "1482.9" "1436.4" "1465.3" "1434.8" "1513.6" "1567.9" "1609.6" "1568.3" "1567.3" "788.4" "" "" "" "" "" "" "" "" "" "" "1315.0" "1189.8" "1278.5" "1073.0" "1262.2" "1440.3" "1360.3" "1296.3" "1437.4" "788.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2868911152044451366" "False" "High" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "0.000" "False" "86.494" "15" "18" "23" "18" "1358" "153.0" "7.17" "90.24" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "25" "0" "1.046" "1.034" "1.102" "1.075" "0.968" "1.056" "1.078" "1.010" "1.378" "1849.4" "1934.2" "1912.5" "2038.5" "1988.6" "1789.6" "1953.4" "1993.2" "1867.9" "2548.0" "" "" "" "" "" "" "" "" "" "" "1640.0" "1602.2" "1668.8" "1524.6" "1658.2" "1644.0" "1650.9" "1647.5" "1713.2" "2548.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "86.471" "53" "6" "24" "6" "158" "18.0" "8.66" "102.71" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "SUMOylation of RNA binding proteins; Formation of Incision Complex in GG-NER; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Meiotic synapsis; PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "27" "0" "0.942" "0.999" "0.933" "0.969" "1.001" "1.028" "1.017" "1.028" "0.748" "3357.8" "3163.3" "3356.1" "3134.4" "3252.6" "3361.8" "3450.9" "3416.4" "3451.5" "2512.8" "" "" "" "" "" "" "" "" "" "" "2977.6" "2620.3" "2928.3" "2344.1" "2712.3" "3088.2" "2916.5" "2823.9" "3165.5" "2512.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "86.407" "40" "10" "16" "10" "306" "33.9" "8.57" "69.92" "10" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "Glucuronidation" "" "1" "0" "0.997" "1.048" "1.001" "1.060" "1.166" "1.021" "1.098" "1.045" "0.470" "1859.9" "1854.1" "1949.0" "1861.3" "1971.3" "2169.3" "1899.0" "2041.7" "1943.2" "874.0" "" "" "" "" "" "" "" "" "" "" "1649.4" "1535.8" "1700.6" "1392.0" "1643.8" "1992.8" "1605.0" "1687.6" "1782.2" "874.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "86.389" "28" "9" "17" "9" "380" "42.1" "5.63" "81.03" "9" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; tRNA processing in the nucleus; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "1.032" "0.996" "1.128" "1.104" "1.083" "1.098" "1.070" "1.044" "0.653" "1523.6" "1572.9" "1517.0" "1718.6" "1682.1" "1649.9" "1673.4" "1630.3" "1591.0" "995.0" "" "" "" "" "" "" "" "" "" "" "1351.1" "1302.9" "1323.7" "1285.3" "1402.6" "1515.6" "1414.3" "1347.6" "1459.2" "995.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "86.361" "48" "9" "21" "9" "214" "24.6" "10.08" "76.23" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "15" "0" "1.100" "1.054" "1.067" "1.096" "0.994" "1.098" "1.011" "1.059" "0.858" "1913.7" "2105.6" "2017.4" "2041.9" "2097.9" "1901.6" "2102.0" "1935.2" "2026.2" "1642.5" "" "" "" "" "" "" "" "" "" "" "1697.0" "1744.1" "1760.3" "1527.0" "1749.4" "1746.8" "1776.5" "1599.6" "1858.3" "1642.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "86.283" "9" "18" "19" "17" "2440" "270.0" "7.11" "77.46" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "30" "1" "1.006" "1.146" "1.005" "1.016" "0.957" "0.914" "0.901" "0.912" "1.274" "1313.0" "1320.6" "1504.2" "1319.2" "1333.9" "1256.7" "1200.2" "1182.8" "1197.2" "1672.4" "" "" "" "" "" "" "" "" "" "" "1164.3" "1093.9" "1312.5" "986.6" "1112.3" "1154.4" "1014.4" "977.7" "1098.0" "1672.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.000" "False" "86.170" "9" "14" "18" "14" "1845" "204.2" "7.12" "60.97" "14" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "1.211" "0.880" "1.075" "0.990" "0.917" "1.036" "0.571" "0.923" "6.778" "637.6" "771.8" "560.9" "685.6" "630.9" "584.5" "660.7" "364.2" "588.2" "4321.5" "" "" "" "" "" "" "" "" "" "" "565.4" "639.3" "489.4" "512.7" "526.1" "536.9" "558.4" "301.1" "539.5" "4321.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5172052490398288729" "False" "High" "IsMasterProtein" "Q9H9S4" "Calcium-binding protein 39-like OS=Homo sapiens OX=9606 GN=CAB39L PE=1 SV=3" "0.000" "False" "86.114" "42" "16" "33" "12" "337" "39.1" "8.40" "110.83" "16" "signal transduction" "cytosol;other cell component" "enzyme regulator activity" "Pf08569" "81617" "ENSG00000102547" "CAB39L" "hsa:81617; Q5TAW6; Q6WG71; Q96FG1; Q9BZ33; Q9H9S4" "Energy dependent regulation of mTOR by LKB1-AMPK" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "2" "0" "1.007" "0.954" "0.983" "0.953" "0.952" "0.924" "0.974" "0.896" "0.570" "2631.5" "2649.4" "2511.8" "2588.0" "2508.6" "2506.1" "2431.0" "2563.5" "2359.0" "1498.8" "" "" "" "" "" "" "" "" "" "" "2333.6" "2194.6" "2191.7" "1935.5" "2091.8" "2302.2" "2054.6" "2118.9" "2163.5" "1498.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "86.097" "15" "15" "17" "13" "1069" "121.7" "5.25" "73.74" "15" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "TBC/RABGAPs" "" "1" "1" "0.939" "0.958" "0.918" "0.975" "0.968" "0.933" "0.919" "0.912" "1.415" "2624.8" "2464.4" "2514.0" "2409.5" "2558.7" "2541.2" "2448.8" "2411.0" "2392.6" "3712.9" "" "" "" "" "" "" "" "" "" "" "2327.6" "2041.4" "2193.6" "1802.0" "2133.6" "2334.4" "2069.6" "1992.9" "2194.4" "3712.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "86.057" "22" "12" "19" "12" "660" "71.9" "7.97" "76.19" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "0.992" "0.988" "0.997" "0.968" "0.994" "1.081" "1.042" "1.014" "0.757" "1609.8" "1597.3" "1590.2" "1604.2" "1557.7" "1600.7" "1740.0" "1677.9" "1632.8" "1218.5" "" "" "" "" "" "" "" "" "" "" "1427.5" "1323.1" "1387.6" "1199.8" "1298.9" "1470.4" "1470.6" "1386.9" "1497.5" "1218.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.000" "False" "85.946" "22" "12" "20" "12" "798" "87.1" "5.31" "83.71" "12" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "VEGFA-VEGFR2 signaling" "3" "0" "1.014" "1.041" "0.965" "1.008" "1.040" "0.992" "0.978" "1.057" "1.332" "2638.7" "2676.4" "2746.1" "2547.1" "2659.5" "2744.9" "2616.8" "2580.1" "2790.2" "3515.9" "" "" "" "" "" "" "" "" "" "" "2339.9" "2217.0" "2396.1" "1904.9" "2217.7" "2521.5" "2211.6" "2132.6" "2559.0" "3515.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "85.918" "43" "13" "25" "13" "336" "38.3" "4.98" "95.20" "13" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "7" "0" "1.032" "1.053" "1.075" "1.081" "1.070" "1.015" "1.047" "1.070" "0.605" "2566.7" "2649.5" "2701.5" "2757.9" "2775.1" "2747.4" "2605.6" "2686.8" "2747.2" "1554.1" "" "" "" "" "" "" "" "" "" "" "2276.1" "2194.7" "2357.2" "2062.6" "2314.1" "2523.8" "2202.1" "2220.8" "2519.6" "1554.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "High" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.000" "False" "85.918" "26" "14" "23" "14" "648" "71.9" "6.21" "90.45" "14" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "1.013" "1.048" "1.014" "1.062" "0.987" "1.033" "1.065" "1.043" "0.806" "1625.9" "1647.6" "1704.0" "1648.5" "1726.9" "1604.6" "1679.8" "1730.9" "1695.6" "1310.8" "" "" "" "" "" "" "" "" "" "" "1441.8" "1364.8" "1486.8" "1232.8" "1440.0" "1474.0" "1419.7" "1430.7" "1555.1" "1310.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "85.753" "20" "18" "20" "18" "958" "108.9" "7.14" "80.54" "18" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.141" "0.976" "1.120" "0.981" "1.031" "1.034" "0.671" "0.991" "6.939" "743.7" "848.8" "725.5" "833.0" "729.8" "766.8" "769.2" "499.2" "737.1" "5161.1" "" "" "" "" "" "" "" "" "" "" "659.5" "703.1" "633.1" "623.0" "608.6" "704.4" "650.1" "412.6" "676.1" "5161.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "85.699" "58" "8" "50" "3" "145" "16.4" "8.09" "185.96" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER" "" "7" "0" "0.952" "0.963" "1.001" "0.975" "0.970" "1.018" "0.991" "0.944" "0.682" "1373.3" "1308.0" "1323.0" "1375.2" "1339.1" "1332.1" "1397.8" "1361.1" "1296.7" "936.6" "" "" "" "" "" "" "" "" "" "" "1217.8" "1083.5" "1154.4" "1028.5" "1116.6" "1223.7" "1181.4" "1125.0" "1189.3" "936.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "85.699" "21" "17" "26" "17" "923" "104.1" "5.57" "88.84" "17" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "0.992" "0.972" "1.022" "0.987" "0.972" "1.106" "0.990" "0.953" "1.665" "2344.6" "2325.8" "2278.1" "2395.6" "2315.1" "2278.5" "2593.4" "2320.5" "2235.3" "3902.5" "" "" "" "" "" "" "" "" "" "" "2079.1" "1926.6" "1987.8" "1791.6" "1930.5" "2093.0" "2191.9" "1918.1" "2050.1" "3902.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "85.678" "36" "11" "16" "11" "363" "39.7" "8.02" "59.93" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "1.085" "1.038" "1.152" "1.101" "1.168" "1.545" "1.392" "1.434" "2.371" "952.2" "1033.2" "988.6" "1097.0" "1048.7" "1112.1" "1471.5" "1325.9" "1365.1" "2257.3" "" "" "" "" "" "" "" "" "" "" "844.4" "855.9" "862.6" "820.4" "874.4" "1021.6" "1243.6" "1096.0" "1251.9" "2257.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.000" "False" "85.528" "38" "10" "20" "10" "330" "37.6" "6.42" "73.07" "10" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "5" "0" "1.064" "1.026" "1.033" "0.981" "1.018" "1.018" "0.816" "0.967" "4.401" "1322.7" "1406.7" "1357.6" "1366.7" "1298.1" "1346.7" "1346.7" "1079.4" "1278.9" "5821.1" "" "" "" "" "" "" "" "" "" "" "1172.9" "1165.3" "1184.6" "1022.1" "1082.4" "1237.1" "1138.2" "892.2" "1173.0" "5821.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "85.467" "39" "5" "41" "3" "115" "11.7" "4.54" "190.57" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "16" "3" "1.047" "1.050" "1.045" "1.088" "1.140" "1.179" "1.167" "1.242" "0.395" "5099.3" "5337.5" "5352.7" "5328.8" "5548.3" "5813.4" "6010.1" "5950.7" "6334.8" "2013.1" "" "" "" "" "" "" "" "" "" "" "4522.0" "4421.3" "4670.5" "3985.2" "4626.5" "5340.2" "5079.5" "4918.7" "5809.9" "2013.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "85.396" "29" "11" "17" "11" "452" "50.2" "6.47" "76.96" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Recycling of eIF2:GDP" "Translation factors; Primary ovarian insufficiency" "3" "0" "0.947" "0.948" "0.978" "0.979" "0.967" "1.173" "1.166" "1.157" "1.219" "1452.2" "1375.3" "1376.6" "1420.2" "1421.4" "1405.0" "1703.1" "1693.8" "1680.2" "1770.0" "" "" "" "" "" "" "" "" "" "" "1287.8" "1139.2" "1201.1" "1062.1" "1185.2" "1290.7" "1439.4" "1400.0" "1541.0" "1770.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6640745081908687038" "False" "High" "IsMasterProtein" "O75521" "Enoyl-CoA delta isomerase 2 OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" "0.000" "False" "85.286" "29" "9" "17" "9" "394" "43.6" "9.00" "70.93" "9" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00378, Pf00887" "10455" "ENSG00000198721" "ECI2" "hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55" "" "" "0" "0" "0.956" "0.999" "1.072" "1.007" "1.037" "1.067" "1.049" "1.045" "0.593" "1768.0" "1689.4" "1766.4" "1894.8" "1779.7" "1833.3" "1887.2" "1855.4" "1848.2" "1049.2" "" "" "" "" "" "" "" "" "" "" "1567.8" "1399.4" "1541.3" "1417.1" "1484.0" "1684.1" "1595.0" "1533.6" "1695.1" "1049.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "85.180" "46" "12" "19" "12" "228" "26.2" "6.44" "81.04" "12" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "Small interfering RNA (siRNA) biogenesis" "" "1" "0" "1.022" "1.016" "1.057" "1.046" "1.037" "1.051" "1.048" "0.946" "0.656" "3194.4" "3264.5" "3244.2" "3374.9" "3341.6" "3314.1" "3357.7" "3346.5" "3023.1" "2096.9" "" "" "" "" "" "" "" "" "" "" "2832.7" "2704.1" "2830.7" "2524.0" "2786.5" "3044.4" "2837.8" "2766.1" "2772.6" "2096.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "85.114" "27" "19" "25" "13" "772" "87.6" "8.41" "92.57" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "" "miRNA regulation of DNA damage response; DNA damage response" "2" "6" "0.972" "0.986" "0.915" "0.959" "0.946" "0.974" "0.950" "0.972" "1.295" "2357.3" "2290.3" "2325.0" "2156.5" "2261.4" "2230.7" "2296.0" "2240.2" "2292.4" "3052.3" "" "" "" "" "" "" "" "" "" "" "2090.4" "1897.2" "2028.6" "1612.7" "1885.7" "2049.1" "1940.5" "1851.7" "2102.4" "3052.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "85.108" "51" "7" "16" "6" "153" "16.9" "6.60" "76.24" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "2" "0" "0.935" "0.908" "0.970" "0.886" "0.809" "0.870" "0.892" "0.929" "0.459" "1565.4" "1464.4" "1421.5" "1519.0" "1387.4" "1266.6" "1362.5" "1396.0" "1454.5" "718.5" "" "" "" "" "" "" "" "" "" "" "1388.2" "1213.0" "1240.3" "1136.0" "1156.9" "1163.5" "1151.6" "1153.9" "1334.0" "718.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "85.082" "45" "11" "21" "11" "233" "26.0" "4.79" "81.68" "11" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "0.968" "0.947" "0.933" "0.833" "0.790" "0.757" "0.832" "0.861" "0.936" "2642.6" "2558.8" "2501.3" "2464.9" "2202.3" "2087.9" "1999.1" "2197.5" "2276.0" "2473.8" "" "" "" "" "" "" "" "" "" "" "2343.4" "2119.6" "2182.5" "1843.4" "1836.4" "1917.9" "1689.6" "1816.4" "2087.4" "2473.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "High" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.000" "False" "84.982" "67" "10" "17" "10" "182" "20.6" "5.21" "70.45" "10" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "1.027" "1.003" "0.952" "0.927" "0.912" "0.900" "1.021" "1.017" "0.372" "1399.6" "1437.1" "1404.4" "1333.1" "1297.9" "1276.9" "1260.2" "1429.7" "1424.0" "520.7" "" "" "" "" "" "" "" "" "" "" "1241.2" "1190.4" "1225.4" "997.0" "1082.2" "1173.0" "1065.1" "1181.7" "1306.0" "520.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772663144839085983" "False" "High" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3" "0.000" "False" "84.860" "42" "13" "22" "13" "403" "45.8" "9.39" "83.23" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6790" "ENSG00000087586" "AURKA" "E1P5F9; hsa:6790; O14965; O60445; O75873; Q9BQD6; Q9UPG5" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA" "Gastric cancer network 1; EGF/EGFR signaling pathway; p53 transcriptional gene network; HDAC6 interactions in the central nervous system" "12" "0" "0.971" "0.986" "0.983" "0.963" "0.993" "0.963" "0.919" "0.909" "0.988" "1293.7" "1256.0" "1275.8" "1271.1" "1246.5" "1285.1" "1246.0" "1188.9" "1176.1" "1278.0" "" "" "" "" "" "" "" "" "" "" "1147.2" "1040.4" "1113.2" "950.6" "1039.4" "1180.5" "1053.1" "982.7" "1078.6" "1278.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "84.838" "47" "8" "20" "8" "225" "24.3" "7.94" "78.65" "8" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "Ciliary landscape" "3" "0" "1.031" "1.003" "1.124" "1.072" "1.080" "1.084" "1.102" "0.996" "0.403" "2438.4" "2514.3" "2445.0" "2741.5" "2613.6" "2633.2" "2643.5" "2686.4" "2427.8" "982.0" "" "" "" "" "" "" "" "" "" "" "2162.4" "2082.7" "2133.4" "2050.3" "2179.4" "2418.9" "2234.2" "2220.5" "2226.6" "982.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "84.825" "9" "20" "23" "20" "2346" "265.4" "6.37" "81.38" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "24" "0" "1.017" "0.917" "1.119" "0.964" "0.934" "1.034" "0.508" "0.961" "9.525" "1073.9" "1092.0" "984.5" "1202.0" "1035.6" "1003.0" "1110.7" "545.5" "1032.5" "10229.6" "" "" "" "" "" "" "" "" "" "" "952.3" "904.5" "859.1" "898.9" "863.6" "921.3" "938.7" "450.9" "946.9" "10229.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "84.823" "12" "15" "24" "15" "1151" "131.6" "4.98" "80.24" "15" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "0.964" "0.952" "0.959" "0.957" "0.976" "1.019" "0.938" "0.967" "2.643" "1734.5" "1672.8" "1650.6" "1663.2" "1660.7" "1693.1" "1767.3" "1627.5" "1678.1" "4584.5" "" "" "" "" "" "" "" "" "" "" "1538.1" "1385.7" "1440.2" "1243.9" "1384.8" "1555.3" "1493.7" "1345.3" "1539.0" "4584.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.000" "False" "84.786" "23" "13" "19" "13" "702" "78.2" "6.62" "82.49" "13" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "0.990" "1.005" "1.031" "1.028" "1.015" "0.948" "1.013" "0.984" "0.577" "1249.1" "1236.5" "1255.5" "1288.4" "1283.9" "1268.3" "1183.6" "1265.0" "1229.2" "720.4" "" "" "" "" "" "" "" "" "" "" "1107.7" "1024.3" "1095.5" "963.6" "1070.6" "1165.0" "1000.4" "1045.6" "1127.4" "720.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696526329741067639" "False" "High" "IsMasterProtein" "Q14344" "Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens OX=9606 GN=GNA13 PE=1 SV=2" "0.000" "False" "84.777" "44" "15" "21" "14" "377" "44.0" "8.00" "81.65" "15" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "10672" "ENSG00000120063" "GNA13" "B2R977; B7Z7R0; F5H1G8; hsa:10672; Q14344; Q8TD70" "G alpha (12/13) signalling events; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; Thrombin signalling through proteinase activated receptors (PARs); Thromboxane signalling through TP receptor" "Thyroid stimulating hormone (TSH) signaling pathway; G protein signaling pathways; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; G13 signaling pathway" "11" "1" "1.102" "0.976" "1.098" "1.158" "1.074" "1.097" "1.068" "1.049" "1.343" "604.4" "666.0" "590.2" "663.8" "699.9" "649.0" "662.9" "645.7" "633.8" "811.5" "" "" "" "" "" "" "" "" "" "" "536.0" "551.7" "515.0" "496.4" "583.6" "596.2" "560.3" "533.7" "581.2" "811.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "84.705" "34" "13" "16" "13" "432" "48.5" "6.09" "65.09" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "" "Male infertility" "1" "0" "0.997" "0.923" "1.222" "1.155" "1.072" "2.208" "1.744" "1.686" "3.440" "567.9" "566.0" "523.9" "694.2" "656.0" "608.7" "1253.7" "990.2" "957.5" "1953.4" "" "" "" "" "" "" "" "" "" "" "503.6" "468.9" "457.1" "519.2" "547.0" "559.1" "1059.6" "818.5" "878.2" "1953.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "84.657" "25" "18" "25" "17" "775" "87.7" "7.15" "83.29" "18" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "3" "0" "0.988" "0.968" "1.167" "0.986" "0.972" "1.097" "0.675" "0.977" "6.768" "880.7" "870.0" "852.5" "1027.9" "868.2" "856.1" "965.9" "594.7" "860.1" "5960.1" "" "" "" "" "" "" "" "" "" "" "781.0" "720.7" "743.9" "768.8" "723.9" "786.4" "816.4" "491.5" "788.9" "5960.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "84.615" "39" "11" "36" "11" "310" "34.6" "6.52" "118.03" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "0.937" "0.862" "0.889" "0.856" "0.774" "0.827" "0.892" "0.943" "0.610" "3792.3" "3554.5" "3270.8" "3371.2" "3245.2" "2937.0" "3137.4" "3382.8" "3574.5" "2313.1" "" "" "" "" "" "" "" "" "" "" "3362.9" "2944.4" "2853.9" "2521.2" "2706.1" "2698.0" "2651.6" "2796.2" "3278.3" "2313.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.000" "False" "84.537" "39" "11" "19" "11" "319" "36.6" "6.30" "81.60" "11" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "1.023" "0.903" "0.955" "0.918" "0.922" "1.082" "0.889" "0.853" "0.917" "1468.0" "1501.7" "1326.3" "1402.5" "1348.2" "1353.7" "1587.8" "1304.7" "1252.9" "1345.6" "" "" "" "" "" "" "" "" "" "" "1301.8" "1243.9" "1157.3" "1048.9" "1124.2" "1243.5" "1342.0" "1078.5" "1149.1" "1345.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "84.360" "32" "12" "29" "12" "375" "42.6" "8.56" "108.57" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "5" "0" "0.995" "0.961" "1.025" "0.955" "0.976" "0.954" "0.896" "0.919" "1.701" "3452.7" "3436.8" "3316.4" "3539.5" "3298.9" "3370.4" "3292.9" "3093.6" "3172.1" "5873.9" "" "" "" "" "" "" "" "" "" "" "3061.8" "2846.8" "2893.7" "2647.0" "2750.8" "3096.1" "2783.0" "2557.1" "2909.3" "5873.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "84.329" "45" "11" "23" "11" "240" "26.7" "5.20" "86.36" "11" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "RHOD GTPase cycle" "" "1" "0" "0.996" "1.005" "0.966" "0.926" "0.960" "0.872" "0.896" "0.888" "0.758" "3601.9" "3587.6" "3618.4" "3480.8" "3337.1" "3458.1" "3141.9" "3228.5" "3198.5" "2729.7" "" "" "" "" "" "" "" "" "" "" "3194.1" "2971.8" "3157.2" "2603.2" "2782.7" "3176.6" "2655.4" "2668.6" "2933.4" "2729.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "84.261" "40" "8" "26" "8" "261" "29.8" "5.55" "122.49" "8" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "0.997" "1.002" "1.030" "1.034" "0.999" "0.966" "0.960" "1.024" "0.633" "3065.7" "3055.5" "3072.0" "3158.6" "3169.4" "3062.2" "2960.9" "2942.0" "3139.0" "1941.6" "" "" "" "" "" "" "" "" "" "" "2718.6" "2531.0" "2680.4" "2362.2" "2642.9" "2812.9" "2502.5" "2431.8" "2878.9" "1941.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "84.101" "51" "14" "18" "14" "372" "40.5" "6.25" "74.99" "14" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.965" "0.974" "1.043" "1.011" "1.074" "1.019" "1.026" "0.968" "0.523" "1172.3" "1130.9" "1141.4" "1222.9" "1184.9" "1259.2" "1194.5" "1202.9" "1135.4" "613.0" "" "" "" "" "" "" "" "" "" "" "1039.6" "936.8" "995.9" "914.6" "988.0" "1156.7" "1009.5" "994.3" "1041.3" "613.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "84.087" "33" "13" "29" "8" "393" "43.4" "6.62" "104.45" "13" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "102" "0" "1.029" "0.995" "1.090" "1.052" "1.053" "1.099" "1.144" "1.004" "0.578" "1655.6" "1703.6" "1646.9" "1803.9" "1742.3" "1743.5" "1818.9" "1894.8" "1663.0" "956.4" "" "" "" "" "" "" "" "" "" "" "1468.2" "1411.2" "1437.0" "1349.1" "1452.9" "1601.6" "1537.3" "1566.2" "1525.2" "956.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "83.831" "23" "19" "26" "19" "876" "100.6" "5.96" "91.75" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "" "2" "0" "1.024" "0.947" "1.117" "1.004" "0.965" "0.988" "0.469" "0.938" "8.978" "1271.8" "1302.4" "1204.5" "1420.4" "1277.3" "1227.5" "1256.2" "596.1" "1193.3" "11419.1" "" "" "" "" "" "" "" "" "" "" "1127.8" "1078.9" "1051.0" "1062.3" "1065.1" "1127.6" "1061.7" "492.7" "1094.4" "11419.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076863243069163850" "False" "High" "IsMasterProtein" "Q8WX93" "Palladin OS=Homo sapiens OX=9606 GN=PALLD PE=1 SV=3" "0.000" "False" "83.790" "11" "12" "12" "12" "1383" "150.5" "7.09" "56.73" "12" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf07679" "23022" "ENSG00000129116" "PALLD" "B3KTG2; B5MD56; B7ZMM5; hsa:23022; Q7L3E0; Q7Z3W0; Q86WE8; Q8N1M2; Q8WX93; Q9UGA0; Q9UQF5; Q9Y2J6; Q9Y3E9" "" "" "0" "0" "0.986" "1.036" "0.998" "0.961" "0.953" "1.033" "0.833" "1.020" "3.093" "1084.7" "1069.2" "1123.9" "1082.1" "1042.0" "1033.4" "1120.8" "903.6" "1105.9" "3355.3" "" "" "" "" "" "" "" "" "" "" "961.9" "885.7" "980.6" "809.3" "868.8" "949.3" "947.3" "746.9" "1014.3" "3355.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "83.741" "31" "8" "19" "8" "302" "32.8" "8.54" "81.33" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "5" "0" "1.027" "1.040" "1.032" "1.057" "1.032" "1.059" "1.082" "1.026" "0.418" "2994.2" "3074.8" "3113.1" "3089.9" "3165.3" "3089.5" "3170.6" "3238.9" "3071.6" "1250.6" "" "" "" "" "" "" "" "" "" "" "2655.2" "2547.0" "2716.3" "2310.9" "2639.4" "2838.0" "2679.6" "2677.2" "2817.0" "1250.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "83.713" "18" "14" "16" "14" "1015" "114.3" "5.59" "67.81" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "Condensation of Prometaphase Chromosomes" "" "1" "0" "0.950" "0.920" "1.036" "0.904" "0.880" "0.945" "0.428" "0.984" "8.865" "921.8" "876.1" "848.2" "955.1" "833.5" "810.8" "871.0" "394.4" "906.6" "8171.9" "" "" "" "" "" "" "" "" "" "" "817.5" "725.7" "740.1" "714.3" "695.0" "744.8" "736.1" "326.0" "831.5" "8171.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "High" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.000" "False" "83.627" "27" "17" "23" "17" "592" "67.5" "4.60" "87.02" "17" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "Maturation of spike protein; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Calnexin/calreticulin cycle; Maturation of spike protein" "15q11q13 copy number variation" "9" "0" "1.100" "0.943" "1.093" "1.046" "1.220" "1.091" "1.073" "1.221" "1.954" "2448.6" "2693.6" "2308.4" "2675.1" "2561.1" "2986.6" "2671.7" "2628.1" "2989.5" "4783.7" "" "" "" "" "" "" "" "" "" "" "2171.4" "2231.3" "2014.1" "2000.6" "2135.6" "2743.5" "2258.0" "2172.3" "2741.8" "4783.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "83.580" "53" "10" "26" "10" "180" "19.6" "6.02" "87.19" "10" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "" "3" "0" "1.064" "1.075" "1.052" "1.052" "1.046" "1.052" "1.048" "1.013" "0.526" "1995.6" "2124.3" "2145.2" "2100.4" "2099.4" "2087.8" "2099.0" "2091.3" "2021.7" "1050.0" "" "" "" "" "" "" "" "" "" "" "1769.7" "1759.7" "1871.8" "1570.8" "1750.6" "1917.9" "1774.0" "1728.6" "1854.1" "1050.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "83.560" "63" "9" "28" "9" "154" "16.6" "6.58" "109.08" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.977" "0.949" "0.995" "0.914" "0.892" "0.889" "0.989" "0.958" "0.510" "3197.5" "3123.0" "3034.7" "3181.3" "2922.4" "2853.0" "2843.3" "3161.0" "3063.0" "1631.8" "" "" "" "" "" "" "" "" "" "" "2835.5" "2586.9" "2647.9" "2379.2" "2436.9" "2620.8" "2403.0" "2612.8" "2809.2" "1631.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2236702861585061595" "False" "High" "IsMasterProtein" "P57721" "Poly(rC)-binding protein 3 OS=Homo sapiens OX=9606 GN=PCBP3 PE=1 SV=2" "0.000" "False" "83.550" "21" "7" "19" "1" "371" "39.4" "8.07" "71.75" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity" "Pf00013, Pf07650" "54039" "ENSG00000183570" "PCBP3" "A8MPS2; A8MQ26; B7WNN9; B7WPC1; P57721; Q8N9K6; Q96EP6" "" "" "0" "0" "1.194" "1.093" "0.990" "1.026" "1.077" "1.172" "0.927" "1.115" "4.943" "168.8" "201.6" "184.6" "167.2" "173.3" "181.9" "198.0" "156.5" "188.2" "834.5" "" "" "" "" "" "" "" "" "" "" "149.7" "167.0" "161.0" "125.0" "144.5" "167.1" "167.3" "129.4" "172.6" "834.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "83.528" "42" "9" "25" "9" "224" "25.2" "4.92" "104.97" "9" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "0.974" "0.995" "0.969" "0.974" "0.976" "0.990" "0.988" "0.977" "0.526" "3250.8" "3164.8" "3234.9" "3150.3" "3165.4" "3172.7" "3219.1" "3212.1" "3175.8" "1708.4" "" "" "" "" "" "" "" "" "" "" "2882.7" "2621.6" "2822.6" "2356.0" "2639.5" "2914.4" "2720.6" "2655.1" "2912.6" "1708.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115574768027660471" "False" "High" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=4" "0.000" "False" "83.518" "33" "15" "22" "14" "517" "57.2" "6.99" "83.39" "15" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "219" "ENSG00000137124" "ALDH1B1" "B2R8F0; hsa:219; P30837; Q8WX76; Q9BV45" "Mitochondrial protein degradation; Ethanol oxidation" "" "2" "0" "1.024" "0.998" "1.007" "1.037" "1.073" "1.029" "1.036" "1.061" "1.145" "1319.0" "1350.1" "1316.3" "1328.0" "1367.4" "1414.8" "1356.7" "1366.5" "1399.9" "1510.2" "" "" "" "" "" "" "" "" "" "" "1169.6" "1118.4" "1148.5" "993.2" "1140.3" "1299.6" "1146.6" "1129.5" "1283.9" "1510.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "83.482" "13" "12" "20" "12" "1011" "113.7" "7.28" "74.63" "12" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "" "2" "0" "1.047" "1.053" "1.017" "1.055" "1.117" "1.028" "1.022" "0.968" "0.526" "1827.8" "1913.5" "1925.2" "1858.6" "1928.3" "2041.7" "1878.9" "1867.2" "1770.1" "962.1" "" "" "" "" "" "" "" "" "" "" "1620.9" "1585.1" "1679.9" "1390.0" "1608.0" "1875.5" "1588.0" "1543.4" "1623.4" "962.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062683060595135562" "False" "High" "IsMasterProtein" "Q9NVE7" "4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1" "0.000" "False" "83.320" "21" "14" "15" "14" "773" "85.9" "6.28" "62.62" "14" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01937, Pf03630" "55229" "ENSG00000157881; ENSG00000273494" "PANK4" "B9DI84; hsa:55229; Q53EU3; Q5TA84; Q7RTX3; Q9H3X5; Q9NVE7" "Vitamin B5 (pantothenate) metabolism" "1p36 copy number variation syndrome" "2" "0" "0.931" "0.930" "1.016" "0.935" "0.974" "1.318" "1.286" "1.172" "1.348" "1533.7" "1427.2" "1427.1" "1558.9" "1433.3" "1494.1" "2021.7" "1972.6" "1797.3" "2067.6" "" "" "" "" "" "" "" "" "" "" "1360.1" "1182.3" "1245.2" "1165.8" "1195.2" "1372.5" "1708.6" "1630.5" "1648.4" "2067.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2085339884306235514" "False" "High" "IsMasterProtein" "Q13501" "Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1" "0.000" "False" "83.319" "32" "10" "26" "10" "440" "47.7" "5.22" "101.70" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00564, Pf00569, Pf16577" "8878" "ENSG00000161011; ENSG00000284099" "SQSTM1" "A6NFN7; B2R661; B3KUW5; hsa:8878; Q13446; Q13501; Q9BUV7; Q9BVS6; Q9UEU1" "Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; Nuclear events mediated by NFE2L2; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy" "IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome; Opioid receptor pathways; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; HDAC6 interactions in the central nervous system" "24" "0" "0.978" "1.080" "0.950" "0.998" "1.015" "1.056" "1.055" "1.105" "1.207" "1314.9" "1286.3" "1419.9" "1248.7" "1312.8" "1334.2" "1388.1" "1387.9" "1452.7" "1587.5" "" "" "" "" "" "" "" "" "" "" "1166.1" "1065.5" "1238.9" "933.9" "1094.7" "1225.6" "1173.2" "1147.2" "1332.3" "1587.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "83.285" "51" "12" "16" "12" "295" "33.2" "5.36" "64.43" "12" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "8" "0" "1.003" "0.983" "0.979" "1.019" "1.054" "1.006" "1.004" "1.053" "0.977" "1508.7" "1513.4" "1483.3" "1477.0" "1538.1" "1590.1" "1518.1" "1514.8" "1588.5" "1474.7" "" "" "" "" "" "" "" "" "" "" "1337.9" "1253.7" "1294.3" "1104.6" "1282.6" "1460.7" "1283.0" "1252.1" "1456.9" "1474.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "High" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.000" "False" "83.175" "48" "4" "18" "4" "126" "13.9" "10.32" "81.67" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.072" "0.985" "1.146" "1.042" "0.927" "1.174" "1.028" "0.916" "0.552" "1239.0" "1327.6" "1220.6" "1419.6" "1291.5" "1148.2" "1455.1" "1273.4" "1134.8" "684.2" "" "" "" "" "" "" "" "" "" "" "1098.7" "1099.8" "1065.0" "1061.6" "1076.9" "1054.8" "1229.8" "1052.6" "1040.8" "684.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "83.126" "38" "10" "20" "10" "339" "37.8" "4.97" "81.85" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "Cytosolic iron-sulfur cluster assembly" "2q11.2 copy number variation syndrome" "2" "0" "1.005" "0.995" "1.023" "1.038" "1.004" "1.020" "1.018" "0.940" "0.727" "1946.5" "1955.9" "1937.7" "1990.8" "2020.9" "1953.4" "1985.7" "1980.7" "1830.0" "1414.6" "" "" "" "" "" "" "" "" "" "" "1726.2" "1620.2" "1690.8" "1488.8" "1685.2" "1794.5" "1678.2" "1637.2" "1678.3" "1414.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "83.108" "38" "12" "25" "12" "380" "39.8" "8.94" "105.65" "12" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "Integrin-mediated cell adhesion; Focal adhesion" "5" "0" "0.978" "0.885" "0.970" "0.930" "0.876" "0.919" "0.603" "0.954" "7.083" "1334.4" "1305.1" "1180.6" "1294.3" "1241.0" "1168.8" "1226.1" "804.8" "1273.1" "9451.3" "" "" "" "" "" "" "" "" "" "" "1183.3" "1081.1" "1030.2" "968.0" "1034.8" "1073.6" "1036.2" "665.2" "1167.6" "9451.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "879339039440763847" "False" "High" "IsMasterProtein" "A6NI72" "Putative neutrophil cytosol factor 1B OS=Homo sapiens OX=9606 GN=NCF1B PE=5 SV=2" "0.000" "False" "83.061" "31" "10" "14" "10" "391" "44.8" "9.13" "58.40" "10" "other metabolic processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "" "" "NCF1B" "A6NI72" "" "" "0" "0" "1.051" "0.909" "1.007" "0.998" "0.955" "0.968" "0.228" "0.925" "14.349" "562.8" "591.5" "511.6" "566.7" "561.7" "537.5" "544.5" "128.2" "520.6" "8075.0" "" "" "" "" "" "" "" "" "" "" "499.1" "490.0" "446.4" "423.8" "468.4" "493.7" "460.2" "106.0" "477.5" "8075.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6736379060781022662" "False" "High" "IsMasterProtein" "P21399" "Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3" "0.000" "False" "83.061" "20" "18" "24" "18" "889" "98.3" "6.68" "75.69" "18" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "48" "ENSG00000122729" "ACO1" "D3DRK7; hsa:48; P21399; Q14652; Q5VZA7" "Iron uptake and transport" "Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)" "3" "0" "1.047" "1.058" "1.080" "1.053" "1.050" "1.068" "1.063" "0.984" "0.973" "2601.7" "2723.6" "2752.2" "2809.0" "2740.5" "2731.2" "2779.2" "2765.4" "2560.9" "2531.2" "" "" "" "" "" "" "" "" "" "" "2307.2" "2256.1" "2401.5" "2100.7" "2285.2" "2508.9" "2348.9" "2285.8" "2348.7" "2531.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "83.047" "26" "21" "23" "21" "819" "93.4" "5.72" "77.20" "21" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "ISG15 antiviral mechanism; HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.982" "0.877" "0.949" "0.880" "0.849" "1.000" "0.650" "0.981" "6.965" "1839.1" "1805.4" "1613.3" "1746.2" "1619.1" "1560.6" "1838.6" "1195.9" "1805.0" "12809.6" "" "" "" "" "" "" "" "" "" "" "1630.9" "1495.5" "1407.7" "1305.9" "1350.1" "1433.6" "1553.9" "988.5" "1655.4" "12809.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "83.038" "35" "12" "30" "12" "352" "39.9" "4.53" "120.64" "12" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "1.027" "1.087" "1.028" "1.028" "1.085" "1.032" "1.052" "1.106" "0.817" "2736.9" "2810.7" "2975.3" "2813.5" "2812.6" "2968.8" "2823.9" "2878.0" "3027.9" "2234.8" "" "" "" "" "" "" "" "" "" "" "2427.0" "2328.3" "2596.1" "2104.2" "2345.4" "2727.2" "2386.6" "2378.9" "2777.0" "2234.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7384087443166083849" "False" "High" "IsMasterProtein" "O14562" "Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2" "0.000" "False" "82.976" "31" "9" "20" "9" "309" "33.4" "5.77" "75.77" "9" "" "" "" "Pf00240" "56061" "ENSG00000103353" "UBFD1" "A8MW58; D3DWF2; hsa:56061; O14562" "" "" "0" "0" "0.917" "0.911" "0.878" "0.870" "0.872" "0.831" "0.919" "0.927" "0.773" "2954.7" "2709.6" "2692.7" "2592.8" "2570.4" "2577.9" "2456.6" "2714.8" "2738.8" "2284.3" "" "" "" "" "" "" "" "" "" "" "2620.1" "2244.5" "2349.5" "1939.1" "2143.4" "2368.1" "2076.2" "2244.0" "2511.8" "2284.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "82.957" "28" "15" "31" "15" "565" "65.3" "8.91" "111.72" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "mRNA Splicing - Major Pathway" "" "1" "0" "1.016" "0.995" "0.995" "0.972" "1.009" "0.988" "0.971" "0.977" "0.528" "3540.8" "3599.1" "3524.0" "3524.1" "3439.9" "3574.4" "3497.5" "3439.7" "3458.2" "1868.8" "" "" "" "" "" "" "" "" "" "" "3139.9" "2981.3" "3074.9" "2635.5" "2868.4" "3283.5" "2955.9" "2843.1" "3171.6" "1868.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "82.891" "42" "12" "31" "11" "239" "27.1" "5.90" "116.47" "12" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "10" "1" "0.972" "0.951" "0.954" "0.966" "0.979" "0.969" "0.977" "0.979" "0.429" "2849.4" "2769.7" "2710.6" "2719.7" "2752.6" "2788.5" "2760.5" "2783.6" "2788.7" "1223.5" "" "" "" "" "" "" "" "" "" "" "2526.8" "2294.3" "2365.1" "2034.0" "2295.3" "2561.5" "2333.0" "2300.8" "2557.6" "1223.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "82.886" "32" "13" "20" "13" "502" "52.9" "6.64" "70.09" "13" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "13" "0" "0.936" "0.976" "0.961" "0.949" "0.927" "1.059" "0.967" "1.024" "2.125" "2098.0" "1964.2" "2047.2" "2015.5" "1990.8" "1945.9" "2221.9" "2029.4" "2147.6" "4457.8" "" "" "" "" "" "" "" "" "" "" "1860.5" "1627.0" "1786.3" "1507.3" "1660.0" "1787.5" "1877.9" "1677.5" "1969.6" "4457.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "High" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.000" "False" "82.877" "29" "12" "23" "12" "482" "53.5" "8.51" "82.61" "12" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.003" "1.021" "1.032" "1.042" "1.053" "1.008" "1.033" "0.985" "0.523" "3106.2" "3115.9" "3172.2" "3205.7" "3236.8" "3272.1" "3132.6" "3209.4" "3058.9" "1625.4" "" "" "" "" "" "" "" "" "" "" "2754.5" "2581.0" "2767.9" "2397.4" "2699.1" "3005.8" "2647.5" "2652.8" "2805.4" "1625.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "82.791" "49" "10" "16" "10" "211" "23.8" "6.70" "72.53" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Regulation of HSF1-mediated heat shock response" "Pleural mesothelioma" "2" "0" "1.000" "0.963" "0.999" "1.039" "1.077" "1.142" "1.051" "1.068" "1.450" "2300.1" "2300.4" "2213.9" "2297.6" "2389.6" "2477.5" "2627.7" "2417.1" "2456.1" "3334.5" "" "" "" "" "" "" "" "" "" "" "2039.7" "1905.5" "1931.8" "1718.3" "1992.6" "2275.8" "2220.8" "1997.9" "2252.6" "3334.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "82.580" "31" "11" "35" "11" "399" "45.3" "7.75" "122.62" "11" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "1.018" "1.000" "0.952" "1.027" "1.074" "1.011" "1.087" "0.975" "0.496" "4017.0" "4089.4" "4016.7" "3824.8" "4125.9" "4312.6" "4062.8" "4365.6" "3915.5" "1994.0" "" "" "" "" "" "" "" "" "" "" "3562.2" "3387.5" "3504.8" "2860.5" "3440.4" "3961.6" "3433.7" "3608.4" "3591.0" "1994.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "82.506" "22" "11" "19" "11" "656" "75.0" "5.55" "73.54" "11" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SUMOylation of DNA replication proteins; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "1.007" "0.979" "1.070" "1.059" "1.019" "0.994" "1.007" "0.916" "0.584" "2005.9" "2019.8" "1963.5" "2146.6" "2124.8" "2043.3" "1993.8" "2019.6" "1836.7" "1172.3" "" "" "" "" "" "" "" "" "" "" "1778.8" "1673.1" "1713.3" "1605.4" "1771.8" "1877.0" "1685.1" "1669.3" "1684.5" "1172.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "82.332" "29" "12" "27" "8" "482" "55.1" "5.48" "104.72" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Potential therapeutics for SARS; Estrogen-dependent gene expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "56" "5" "0.977" "0.987" "0.875" "0.884" "0.941" "0.883" "0.853" "0.935" "2.374" "3081.6" "3011.4" "3041.3" "2697.7" "2725.5" "2900.7" "2722.4" "2628.9" "2881.8" "7316.4" "" "" "" "" "" "" "" "" "" "" "2732.7" "2494.5" "2653.7" "2017.5" "2272.7" "2664.6" "2300.8" "2173.0" "2643.0" "7316.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "112556207330102298" "False" "High" "IsMasterProtein" "P15259" "Phosphoglycerate mutase 2 OS=Homo sapiens OX=9606 GN=PGAM2 PE=1 SV=3" "0.000" "False" "82.314" "23" "7" "56" "1" "253" "28.7" "8.88" "184.11" "7" "other metabolic processes;signal transduction;other biological processes" "cytosol" "other molecular function" "Pf00300" "5224" "ENSG00000164708" "PGAM2" "hsa:5224; P15259" "Glycolysis; Gluconeogenesis" "Aerobic glycolysis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "82.314" "54" "11" "25" "11" "210" "23.7" "6.42" "92.31" "11" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.010" "1.039" "1.026" "1.031" "1.003" "0.960" "1.080" "1.081" "0.564" "3944.1" "3983.4" "4099.1" "4046.4" "4066.7" "3955.2" "3786.0" "4261.2" "4264.7" "2226.1" "" "" "" "" "" "" "" "" "" "" "3497.5" "3299.7" "3576.6" "3026.2" "3391.1" "3633.3" "3199.8" "3522.1" "3911.3" "2226.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3785691322693480288" "False" "High" "IsMasterProtein" "O95834" "Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1" "0.000" "False" "82.194" "24" "14" "18" "14" "649" "70.6" "6.32" "69.69" "14" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "24139" "ENSG00000125746" "EML2" "B7Z3I2; B7Z3Q9; hsa:24139; K7ERL7; O95834; Q59EN8; Q8N5A2; Q9UG50" "" "" "0" "0" "1.024" "1.010" "1.062" "1.054" "1.021" "1.146" "1.107" "0.978" "0.699" "1821.8" "1865.6" "1840.3" "1935.3" "1919.3" "1859.6" "2087.1" "2017.0" "1781.2" "1274.0" "" "" "" "" "" "" "" "" "" "" "1615.6" "1545.4" "1605.8" "1447.4" "1600.4" "1708.3" "1763.9" "1667.2" "1633.6" "1274.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "82.018" "77" "7" "60" "7" "105" "11.7" "4.92" "250.24" "7" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "20" "0" "1.011" "1.006" "1.033" "1.012" "1.003" "1.054" "1.039" "1.045" "0.488" "7341.5" "7420.1" "7386.3" "7585.3" "7428.6" "7362.7" "7734.3" "7624.4" "7672.4" "3579.1" "" "" "" "" "" "" "" "" "" "" "6510.3" "6146.5" "6444.9" "5672.8" "6194.4" "6763.5" "6536.8" "6302.1" "7036.6" "3579.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "81.990" "31" "14" "21" "14" "505" "54.4" "7.65" "65.35" "14" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "1.016" "1.015" "1.232" "1.102" "0.995" "1.118" "0.689" "0.970" "6.996" "1085.6" "1102.6" "1102.2" "1337.6" "1196.1" "1080.7" "1213.5" "748.2" "1052.9" "7595.1" "" "" "" "" "" "" "" "" "" "" "962.7" "913.3" "961.7" "1000.4" "997.4" "992.7" "1025.6" "618.4" "965.6" "7595.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.000" "False" "81.988" "18" "16" "17" "16" "963" "104.8" "7.74" "68.00" "16" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "Nef mediated downregulation of MHC class I complex cell surface expression" "" "1" "0" "0.994" "1.028" "1.011" "0.978" "0.988" "0.946" "0.954" "0.958" "1.322" "1675.4" "1665.7" "1722.6" "1694.2" "1639.2" "1656.1" "1585.6" "1598.0" "1604.6" "2215.0" "" "" "" "" "" "" "" "" "" "" "1485.8" "1379.8" "1503.0" "1267.0" "1366.9" "1521.3" "1340.1" "1320.8" "1471.6" "2215.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3943470923424525784" "False" "High" "IsMasterProtein" "Q14116" "Interleukin-18 OS=Homo sapiens OX=9606 GN=IL18 PE=1 SV=1" "0.000" "False" "81.899" "59" "11" "27" "11" "193" "22.3" "4.67" "93.97" "11" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol" "signal transduction activity or receptor binding" "Pf00340" "3606" "ENSG00000150782" "IL18" "hsa:3606; O75599; Q14116; Q6FGY3; Q6WWJ7" "Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Purinergic signaling in leishmaniasis infection; Pyroptosis; Interleukin-18 signaling; Interleukin-1 processing" "Nucleotide-binding oligomerization domain (NOD) pathway; Corticotropin-releasing hormone signaling pathway; IL1 and megakaryocytes in obesity; Development and heterogeneity of the ILC family; TYROBP causal network in microglia; Cytosolic DNA-sensing pathway; IL-18 signaling pathway; Overview of proinflammatory and profibrotic mediators; Lung pathology of COVID-19; Hypertrophy model; Inflammatory bowel disease signaling" "17" "0" "0.991" "0.983" "1.000" "0.975" "0.993" "0.985" "1.015" "0.993" "0.505" "3385.0" "3353.5" "3327.6" "3383.9" "3301.8" "3360.3" "3332.7" "3434.6" "3361.6" "1708.3" "" "" "" "" "" "" "" "" "" "" "3001.7" "2777.9" "2903.5" "2530.7" "2753.2" "3086.8" "2816.7" "2838.9" "3083.0" "1708.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "81.891" "32" "14" "29" "9" "400" "44.4" "6.55" "116.33" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "88" "3" "1.037" "1.050" "1.077" "1.090" "1.084" "1.131" "1.172" "1.120" "0.997" "2226.1" "2307.5" "2338.1" "2397.7" "2425.7" "2412.7" "2517.9" "2609.8" "2494.3" "2219.1" "" "" "" "" "" "" "" "" "" "" "1974.1" "1911.5" "2040.1" "1793.1" "2022.7" "2216.3" "2128.0" "2157.2" "2287.6" "2219.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "81.746" "27" "15" "21" "15" "625" "68.2" "6.42" "80.00" "15" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.986" "1.049" "0.954" "0.973" "0.983" "1.005" "1.029" "1.089" "0.785" "2329.6" "2295.9" "2443.2" "2221.4" "2266.8" "2290.9" "2340.6" "2396.5" "2537.2" "1829.0" "" "" "" "" "" "" "" "" "" "" "2065.9" "1901.8" "2131.8" "1661.3" "1890.2" "2104.4" "1978.2" "1980.9" "2327.0" "1829.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "81.653" "15" "18" "19" "18" "1314" "140.6" "5.03" "71.17" "18" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "" "17q12 copy number variation syndrome" "1" "0" "0.977" "0.954" "0.994" "0.968" "0.927" "0.879" "0.920" "0.970" "1.133" "2928.9" "2862.4" "2794.1" "2910.3" "2835.2" "2716.1" "2574.8" "2695.4" "2841.8" "3318.0" "" "" "" "" "" "" "" "" "" "" "2597.3" "2371.1" "2438.0" "2176.5" "2364.2" "2495.0" "2176.1" "2227.9" "2606.4" "3318.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167076474534668157" "False" "High" "IsMasterProtein" "Q15398" "Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2" "0.000" "False" "81.642" "19" "15" "19" "15" "846" "95.1" "9.00" "71.81" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf03359" "9787" "ENSG00000126787" "DLGAP5" "A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58" "NOTCH3 Intracellular Domain Regulates Transcription" "Complement system in neuronal development and plasticity" "2" "0" "1.009" "0.991" "0.964" "0.911" "0.971" "0.890" "0.720" "0.941" "3.100" "1618.4" "1632.4" "1604.0" "1559.8" "1475.0" "1571.7" "1440.5" "1165.3" "1522.2" "5017.1" "" "" "" "" "" "" "" "" "" "" "1435.2" "1352.2" "1399.6" "1166.5" "1230.0" "1443.8" "1217.5" "963.2" "1396.1" "5017.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "81.553" "45" "8" "23" "8" "219" "23.3" "5.03" "84.63" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Type II interferon signaling" "61" "0" "1.056" "1.025" "1.102" "1.087" "1.012" "1.064" "1.007" "0.949" "0.599" "1989.3" "2100.0" "2038.4" "2192.3" "2161.7" "2012.4" "2116.8" "2004.1" "1887.3" "1190.8" "" "" "" "" "" "" "" "" "" "" "1764.1" "1739.5" "1778.6" "1639.5" "1802.6" "1848.6" "1789.0" "1656.6" "1730.9" "1190.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "81.465" "43" "9" "14" "9" "302" "33.8" "5.49" "62.74" "9" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Metabolism of polyamines" "Methionine de novo and salvage pathway; Amino acid metabolism" "3" "0" "0.854" "0.872" "0.811" "0.808" "0.693" "0.776" "0.580" "0.782" "4.064" "1305.3" "1115.3" "1137.8" "1058.1" "1054.5" "904.3" "1012.6" "757.0" "1020.8" "5304.6" "" "" "" "" "" "" "" "" "" "" "1157.5" "923.9" "992.8" "791.3" "879.3" "830.7" "855.8" "625.7" "936.2" "5304.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "81.233" "25" "9" "64" "4" "417" "44.8" "8.54" "258.19" "9" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Glycolysis; Gluconeogenesis" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "0" "0.983" "1.044" "0.950" "0.991" "1.058" "0.893" "1.042" "0.902" "0.463" "686.8" "675.4" "717.2" "652.5" "680.5" "726.7" "613.5" "715.9" "619.5" "318.1" "" "" "" "" "" "" "" "" "" "" "609.0" "559.5" "625.8" "487.9" "567.5" "667.6" "518.5" "591.7" "568.2" "318.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "81.207" "36" "16" "24" "15" "419" "48.1" "6.68" "88.92" "16" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "0" "0.935" "0.923" "0.951" "0.924" "0.893" "1.012" "0.953" "0.980" "2.539" "2488.0" "2327.3" "2296.1" "2367.0" "2300.0" "2222.4" "2517.7" "2370.0" "2439.1" "6317.1" "" "" "" "" "" "" "" "" "" "" "2206.3" "1927.8" "2003.4" "1770.2" "1917.9" "2041.5" "2127.8" "1959.0" "2237.0" "6317.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "80.859" "49" "10" "16" "10" "279" "29.3" "8.57" "65.90" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "1.078" "1.031" "1.139" "1.150" "1.058" "1.113" "1.015" "0.903" "0.739" "1078.7" "1163.3" "1112.2" "1228.3" "1241.1" "1141.7" "1200.3" "1095.0" "974.6" "797.2" "" "" "" "" "" "" "" "" "" "" "956.6" "963.6" "970.5" "918.6" "1034.9" "1048.8" "1014.5" "905.1" "893.8" "797.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "80.840" "32" "8" "19" "8" "329" "36.5" "4.64" "83.14" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "0.999" "0.960" "1.008" "1.010" "0.937" "0.992" "0.939" "0.933" "0.902" "2293.5" "2291.4" "2201.5" "2312.8" "2317.2" "2149.1" "2274.7" "2154.3" "2140.0" "2069.4" "" "" "" "" "" "" "" "" "" "" "2033.8" "1898.0" "1920.9" "1729.7" "1932.2" "1974.2" "1922.5" "1780.7" "1962.7" "2069.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "80.759" "38" "12" "23" "12" "311" "34.0" "6.71" "78.97" "12" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "Coenzyme A biosynthesis" "" "1" "0" "1.054" "1.028" "1.092" "1.073" "1.068" "1.117" "1.135" "0.992" "0.590" "1520.3" "1601.9" "1562.7" "1660.6" "1631.8" "1624.5" "1698.6" "1725.6" "1507.5" "896.7" "" "" "" "" "" "" "" "" "" "" "1348.2" "1326.9" "1363.5" "1241.9" "1360.7" "1492.3" "1435.6" "1426.3" "1382.6" "896.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "80.733" "24" "15" "21" "15" "701" "75.7" "6.77" "73.17" "15" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "RAC1 GTPase cycle" "" "1" "0" "1.010" "1.009" "1.045" "1.029" "1.000" "1.031" "1.005" "1.028" "0.970" "1923.9" "1943.2" "1941.5" "2009.6" "1979.9" "1924.0" "1983.0" "1932.6" "1978.4" "1866.5" "" "" "" "" "" "" "" "" "" "" "1706.1" "1609.6" "1694.1" "1502.9" "1650.9" "1767.4" "1675.9" "1597.4" "1814.5" "1866.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "80.704" "33" "11" "24" "9" "415" "45.6" "5.58" "97.31" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome" "5" "0" "1.076" "0.911" "1.099" "0.945" "0.899" "0.985" "0.473" "0.885" "9.996" "1128.6" "1214.8" "1027.7" "1239.8" "1066.4" "1014.5" "1112.1" "534.2" "999.0" "11282.4" "" "" "" "" "" "" "" "" "" "" "1000.9" "1006.3" "896.7" "927.2" "889.2" "931.9" "939.9" "441.6" "916.2" "11282.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.000" "False" "80.610" "30" "15" "21" "15" "547" "62.2" "8.88" "81.73" "15" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "HATs acetylate histones" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "3" "0" "1.058" "1.045" "0.998" "1.027" "1.044" "1.032" "1.034" "0.954" "0.914" "1214.7" "1285.6" "1269.4" "1211.8" "1247.8" "1268.8" "1253.1" "1255.7" "1158.8" "1110.4" "" "" "" "" "" "" "" "" "" "" "1077.2" "1064.9" "1107.6" "906.3" "1040.5" "1165.5" "1059.0" "1037.9" "1062.8" "1110.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "80.353" "36" "12" "19" "12" "420" "46.9" "8.54" "78.38" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "mRNA Splicing - Major Pathway" "" "1" "0" "0.999" "1.012" "0.945" "0.996" "1.036" "0.984" "0.888" "1.014" "2.074" "1913.5" "1911.2" "1936.5" "1808.9" "1905.5" "1983.3" "1883.7" "1699.9" "1940.8" "3968.9" "" "" "" "" "" "" "" "" "" "" "1696.9" "1583.1" "1689.7" "1352.8" "1588.9" "1821.9" "1592.0" "1405.0" "1779.9" "3968.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3013067335374835843" "False" "High" "IsMasterProtein" "Q13153" "Serine/threonine-protein kinase PAK 1 OS=Homo sapiens OX=9606 GN=PAK1 PE=1 SV=2" "0.000" "False" "80.189" "23" "10" "22" "6" "545" "60.6" "5.76" "90.07" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5058" "ENSG00000149269" "PAK1" "hsa:5058; O75561; Q13153; Q13567; Q32M53; Q32M54; Q86W79" "CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOU GTPase cycle; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; MAPK6/MAPK4 signaling; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; Generation of second messenger molecules; RHOQ GTPase cycle; RHOV GTPase cycle; EPHB-mediated forward signaling; Ephrin signaling; G beta:gamma signalling through CDC42; Sema3A PAK dependent Axon repulsion; Signal transduction by L1; DSCAM interactions; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Androgen receptor network in prostate cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway; T-cell receptor signaling pathway" "56" "0" "1.055" "0.930" "1.088" "1.099" "1.074" "1.166" "1.162" "1.140" "0.567" "538.4" "567.7" "500.9" "586.0" "591.7" "578.0" "627.5" "625.5" "614.0" "305.4" "" "" "" "" "" "" "" "" "" "" "477.4" "470.3" "437.0" "438.2" "493.4" "530.9" "530.3" "517.0" "563.1" "305.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "79.972" "43" "12" "33" "12" "241" "27.5" "6.60" "119.35" "12" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "7" "0" "1.025" "1.016" "1.034" "1.002" "1.047" "1.062" "1.087" "1.026" "0.544" "5973.5" "6121.2" "6069.3" "6173.9" "5986.9" "6252.4" "6343.4" "6490.9" "6127.3" "3251.2" "" "" "" "" "" "" "" "" "" "" "5297.2" "5070.5" "5295.8" "4617.3" "4992.2" "5743.5" "5361.2" "5365.2" "5619.6" "3251.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "79.956" "17" "19" "19" "19" "1098" "123.8" "8.65" "69.17" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.076" "0.964" "1.028" "1.010" "1.043" "1.033" "0.474" "0.950" "9.317" "1262.4" "1358.9" "1217.2" "1297.3" "1275.3" "1316.6" "1304.3" "597.8" "1198.8" "11761.0" "" "" "" "" "" "" "" "" "" "" "1119.4" "1125.6" "1062.1" "970.2" "1063.4" "1209.5" "1102.3" "494.1" "1099.5" "11761.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "79.893" "38" "11" "14" "11" "326" "36.1" "9.17" "59.48" "11" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "HuR (ELAVL1) binds and stabilizes mRNA" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "10" "0" "1.006" "0.976" "1.002" "0.985" "0.956" "1.012" "0.655" "0.922" "6.589" "728.8" "733.1" "711.1" "730.0" "717.5" "697.0" "737.3" "477.6" "671.7" "4802.0" "" "" "" "" "" "" "" "" "" "" "646.3" "607.3" "620.5" "545.9" "598.3" "640.3" "623.1" "394.8" "616.1" "4802.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8147219015132361751" "False" "High" "IsMasterProtein" "Q96A19" "Coiled-coil domain-containing protein 102A OS=Homo sapiens OX=9606 GN=CCDC102A PE=1 SV=2" "0.000" "False" "79.860" "27" "14" "18" "14" "550" "62.6" "5.58" "73.25" "14" "" "cytoskeleton" "" "Pf01576" "92922" "ENSG00000135736" "CCDC102A" "hsa:92922; Q96A19; Q9BT74" "" "" "0" "0" "0.965" "0.939" "0.945" "0.996" "1.001" "0.957" "0.933" "0.933" "0.822" "1253.4" "1209.7" "1176.7" "1183.9" "1248.6" "1255.0" "1199.4" "1169.3" "1169.1" "1029.9" "" "" "" "" "" "" "" "" "" "" "1111.5" "1002.0" "1026.7" "885.4" "1041.1" "1152.9" "1013.7" "966.5" "1072.3" "1029.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134922039646345365" "False" "High" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "0.000" "False" "79.834" "18" "11" "19" "11" "726" "79.4" "5.55" "72.03" "11" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "Platelet degranulation" "" "1" "0" "0.895" "0.939" "0.969" "0.943" "0.912" "1.068" "0.999" "0.953" "1.247" "954.0" "853.4" "895.4" "924.3" "899.9" "869.7" "1019.3" "952.8" "909.4" "1189.7" "" "" "" "" "" "" "" "" "" "" "846.0" "706.9" "781.3" "691.3" "750.4" "798.9" "861.4" "787.5" "834.0" "1189.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "79.688" "8" "16" "19" "15" "2647" "280.6" "6.06" "68.90" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "14" "0" "1.030" "0.968" "1.045" "0.937" "0.937" "0.962" "0.742" "1.000" "4.166" "1180.3" "1215.5" "1142.7" "1233.1" "1106.0" "1105.5" "1135.9" "875.4" "1180.4" "4916.9" "" "" "" "" "" "" "" "" "" "" "1046.7" "1006.9" "997.0" "922.2" "922.2" "1015.5" "960.0" "723.6" "1082.6" "4916.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "High" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.000" "False" "79.654" "58" "11" "14" "11" "207" "23.1" "6.93" "58.11" "11" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "0.991" "0.960" "1.013" "1.021" "1.029" "1.063" "1.054" "0.957" "0.483" "1672.6" "1658.4" "1605.1" "1693.8" "1707.6" "1721.6" "1777.4" "1762.6" "1600.3" "807.4" "" "" "" "" "" "" "" "" "" "" "1483.2" "1373.7" "1400.5" "1266.7" "1423.9" "1581.5" "1502.2" "1456.9" "1467.7" "807.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3321226471008760" "False" "High" "IsMasterProtein" "Q9Y2Q3" "Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3" "0.000" "False" "79.487" "50" "10" "20" "10" "226" "25.5" "8.41" "75.53" "10" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01323" "373156" "ENSG00000197448" "GSTK1" "B4DIH1; B4DSY2; hsa:373156; Q6P4H0; Q7Z520; Q9P1S4; Q9Y2Q3" "Peroxisomal protein import; Glutathione conjugation" "Metapathway biotransformation Phase I and II" "3" "0" "1.049" "1.048" "1.015" "1.024" "1.071" "1.016" "1.002" "1.037" "0.909" "2787.8" "2923.8" "2921.6" "2830.2" "2853.5" "2985.4" "2833.7" "2794.3" "2891.1" "2534.9" "" "" "" "" "" "" "" "" "" "" "2472.2" "2421.9" "2549.2" "2116.6" "2379.4" "2742.4" "2394.9" "2309.7" "2651.5" "2534.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "High" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.000" "False" "79.442" "45" "13" "19" "13" "334" "38.4" "6.04" "70.12" "13" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "Cyclin A/B1/B2 associated events during G2/M transition" "" "1" "0" "0.941" "0.956" "0.981" "0.973" "0.931" "1.008" "1.004" "0.981" "0.801" "2158.5" "2030.7" "2063.2" "2117.8" "2099.2" "2009.3" "2174.8" "2167.1" "2118.2" "1729.9" "" "" "" "" "" "" "" "" "" "" "1914.1" "1682.1" "1800.2" "1583.9" "1750.4" "1845.8" "1838.1" "1791.3" "1942.7" "1729.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "79.393" "55" "7" "36" "7" "152" "17.1" "6.57" "126.13" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "28" "0" "1.080" "1.049" "0.936" "1.072" "1.010" "1.078" "1.072" "1.135" "0.649" "3408.8" "3682.7" "3576.6" "3191.7" "3653.7" "3444.6" "3676.2" "3652.9" "3870.1" "2213.0" "" "" "" "" "" "" "" "" "" "" "3022.9" "3050.6" "3120.7" "2387.0" "3046.7" "3164.2" "3107.0" "3019.4" "3549.4" "2213.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "79.392" "25" "9" "18" "9" "475" "53.5" "9.09" "78.55" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "7" "0" "1.011" "1.021" "0.960" "1.057" "1.025" "1.099" "1.061" "1.032" "1.211" "1915.2" "1936.3" "1955.5" "1839.0" "2024.9" "1962.6" "2105.3" "2032.4" "1975.6" "2318.8" "" "" "" "" "" "" "" "" "" "" "1698.3" "1603.9" "1706.3" "1375.3" "1688.5" "1802.9" "1779.3" "1680.0" "1811.9" "2318.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "676002530395001225" "False" "High" "IsMasterProtein" "Q14766" "Latent-transforming growth factor beta-binding protein 1 OS=Homo sapiens OX=9606 GN=LTBP1 PE=1 SV=4" "0.000" "False" "79.322" "12" "17" "20" "17" "1721" "186.7" "5.96" "67.15" "17" "signal transduction;other biological processes" "extracellular matrix;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00683, Pf07645, Pf12662" "4052" "ENSG00000049323" "LTBP1" "A1L3V1; hsa:4052; P22064; Q14766; Q53SD8; Q53SF3; Q53SG1; Q59HF7; Q8TD95" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Molecules associated with elastic fibres; TGF-beta receptor signaling activates SMADs" "Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling" "7" "0" "1.038" "0.971" "0.958" "0.937" "0.889" "0.760" "0.835" "0.869" "0.533" "1692.1" "1756.7" "1642.5" "1621.4" "1584.7" "1504.3" "1285.8" "1412.6" "1470.3" "902.3" "" "" "" "" "" "" "" "" "" "" "1500.5" "1455.1" "1433.1" "1212.6" "1321.4" "1381.9" "1086.7" "1167.6" "1348.4" "902.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3006741669515463279" "False" "High" "IsMasterProtein" "Q8WUD1" "Ras-related protein Rab-2B OS=Homo sapiens OX=9606 GN=RAB2B PE=1 SV=1" "0.000" "False" "79.190" "54" "10" "17" "3" "216" "24.2" "7.83" "65.59" "10" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "84932" "ENSG00000129472" "RAB2B" "B2RD03; D3DS24; hsa:84932; Q6NZ33; Q8WUD1" "RAB geranylgeranylation" "" "1" "0" "0.998" "0.916" "1.066" "1.092" "0.983" "1.058" "0.998" "1.051" "0.792" "243.8" "243.2" "223.4" "259.9" "266.3" "239.8" "258.0" "243.4" "256.2" "193.0" "" "" "" "" "" "" "" "" "" "" "216.2" "201.5" "194.9" "194.4" "222.1" "220.3" "218.1" "201.2" "235.0" "193.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "79.125" "34" "9" "22" "9" "239" "25.3" "4.92" "81.95" "9" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.074" "1.087" "1.045" "1.088" "1.030" "1.141" "1.090" "1.122" "0.654" "1641.5" "1762.5" "1784.7" "1715.3" "1785.2" "1691.3" "1872.4" "1788.9" "1842.0" "1072.9" "" "" "" "" "" "" "" "" "" "" "1455.7" "1459.9" "1557.2" "1282.8" "1488.7" "1553.6" "1582.5" "1478.7" "1689.4" "1072.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "79.090" "18" "15" "19" "15" "941" "107.2" "6.46" "76.36" "15" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "" "1" "0" "1.017" "1.052" "1.001" "1.055" "1.062" "1.078" "1.056" "1.025" "1.788" "2335.2" "2375.7" "2457.0" "2337.6" "2464.0" "2480.0" "2518.0" "2466.4" "2393.9" "4176.1" "" "" "" "" "" "" "" "" "" "" "2070.8" "1967.9" "2143.8" "1748.2" "2054.6" "2278.1" "2128.1" "2038.7" "2195.5" "4176.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "79.010" "22" "11" "17" "10" "583" "66.2" "8.18" "63.67" "11" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "RHOD GTPase cycle; RHOF GTPase cycle" "Influence of laminopathies on Wnt signaling" "3" "1" "1.011" "1.039" "1.033" "1.043" "1.078" "1.014" "1.144" "1.110" "0.600" "1590.7" "1607.7" "1653.5" "1643.4" "1659.0" "1714.7" "1613.2" "1819.2" "1766.2" "954.0" "" "" "" "" "" "" "" "" "" "" "1410.6" "1331.8" "1442.8" "1229.1" "1383.4" "1575.1" "1363.4" "1503.7" "1619.8" "954.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8632288723347516488" "False" "High" "IsMasterProtein" "Q03013" "Glutathione S-transferase Mu 4 OS=Homo sapiens OX=9606 GN=GSTM4 PE=1 SV=3" "0.000" "False" "79.005" "50" "12" "25" "3" "218" "25.5" "5.90" "86.41" "12" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00043, Pf02798" "2948" "ENSG00000168765" "GSTM4" "A8K765; hsa:2948; Q03013; Q05465; Q32NC1; Q4JNT8; Q6FH87" "Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)" "Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "78.931" "14" "15" "18" "15" "1189" "133.2" "7.59" "69.05" "15" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Synthesis of IP3 and IP4 in the cytosol; PECAM1 interactions" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "13" "0" "1.070" "1.081" "1.041" "1.059" "0.989" "0.986" "0.751" "1.022" "4.823" "904.3" "967.6" "977.3" "941.2" "957.6" "894.7" "891.3" "678.8" "923.8" "4362.1" "" "" "" "" "" "" "" "" "" "" "802.0" "801.5" "852.7" "703.9" "798.5" "821.9" "753.3" "561.1" "847.3" "4362.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "78.881" "48" "8" "21" "8" "160" "18.7" "4.54" "82.70" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Potential therapeutics for SARS; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "12" "0" "1.045" "1.014" "0.971" "0.985" "0.904" "0.950" "0.800" "0.872" "3.909" "1990.5" "2081.0" "2018.5" "1932.8" "1960.8" "1798.5" "1890.4" "1592.0" "1735.6" "7781.1" "" "" "" "" "" "" "" "" "" "" "1765.2" "1723.8" "1761.3" "1445.5" "1635.0" "1652.2" "1597.7" "1315.9" "1591.8" "7781.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.000" "False" "78.818" "45" "10" "20" "8" "208" "23.6" "5.54" "70.36" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "" "7" "1" "0.980" "0.996" "1.013" "1.023" "0.973" "0.958" "0.984" "0.871" "0.492" "1797.0" "1760.6" "1789.3" "1820.2" "1837.5" "1748.2" "1721.0" "1768.5" "1565.9" "884.2" "" "" "" "" "" "" "" "" "" "" "1593.5" "1458.4" "1561.2" "1361.2" "1532.2" "1605.9" "1454.5" "1461.8" "1436.1" "884.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3242855938982215798" "False" "High" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "0.000" "False" "78.815" "48" "16" "21" "16" "344" "39.4" "7.68" "76.75" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "" "Primary ovarian insufficiency" "1" "0" "1.036" "1.071" "1.038" "1.043" "1.115" "1.048" "1.125" "1.050" "0.484" "2279.0" "2360.8" "2440.5" "2365.8" "2377.2" "2540.3" "2389.3" "2563.3" "2393.6" "1102.9" "" "" "" "" "" "" "" "" "" "" "2021.0" "1955.6" "2129.5" "1769.3" "1982.3" "2333.5" "2019.3" "2118.7" "2195.3" "1102.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4005780129157962021" "False" "High" "IsMasterProtein" "Q9BUR4" "Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1" "0.000" "False" "78.740" "28" "10" "13" "10" "548" "59.3" "4.58" "58.41" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "55135" "ENSG00000141499" "WRAP53" "B3KPR9; D3DTQ4; hsa:55135; Q08ET9; Q9BUR4; Q9NW09" "Association of TriC/CCT with target proteins during biosynthesis; Telomere Extension By Telomerase" "" "2" "0" "1.036" "0.961" "1.029" "0.977" "0.910" "0.986" "0.976" "0.976" "0.704" "648.8" "672.5" "623.7" "667.9" "634.2" "590.5" "639.7" "633.6" "633.1" "456.5" "" "" "" "" "" "" "" "" "" "" "575.4" "557.1" "544.2" "499.5" "528.9" "542.5" "540.7" "523.7" "580.7" "456.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "78.705" "34" "10" "20" "10" "348" "38.8" "4.91" "84.01" "10" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.044" "1.035" "1.108" "1.157" "1.109" "1.213" "1.242" "1.166" "0.695" "2298.2" "2398.8" "2378.5" "2546.5" "2659.7" "2549.6" "2786.7" "2854.8" "2679.6" "1596.3" "" "" "" "" "" "" "" "" "" "" "2038.0" "1987.1" "2075.3" "1904.5" "2217.8" "2342.1" "2355.2" "2359.7" "2457.6" "1596.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "78.682" "26" "9" "18" "9" "359" "39.6" "7.17" "70.47" "9" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin activation and detoxification" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "3" "0" "1.077" "1.048" "1.138" "1.135" "1.027" "1.093" "1.119" "1.028" "0.739" "1355.1" "1459.2" "1419.9" "1541.6" "1537.5" "1391.7" "1480.8" "1516.7" "1393.7" "1002.0" "" "" "" "" "" "" "" "" "" "" "1201.7" "1208.7" "1238.9" "1152.9" "1282.1" "1278.5" "1251.5" "1253.7" "1278.2" "1002.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "78.624" "50" "7" "20" "7" "172" "19.3" "5.54" "89.11" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.059" "1.076" "1.126" "1.089" "1.076" "0.984" "1.050" "0.933" "0.585" "2545.2" "2695.8" "2739.4" "2865.8" "2771.1" "2738.4" "2503.7" "2672.1" "2375.8" "1488.9" "" "" "" "" "" "" "" "" "" "" "2257.1" "2233.0" "2390.3" "2143.2" "2310.7" "2515.5" "2116.0" "2208.7" "2178.9" "1488.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "78.593" "27" "10" "22" "10" "367" "40.8" "6.14" "85.72" "10" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "1.069" "1.122" "1.124" "1.124" "1.063" "1.143" "1.129" "1.052" "0.544" "1333.8" "1425.2" "1497.1" "1499.7" "1499.6" "1417.3" "1524.3" "1506.2" "1402.6" "726.3" "" "" "" "" "" "" "" "" "" "" "1182.8" "1180.6" "1306.3" "1121.6" "1250.5" "1302.0" "1288.3" "1244.9" "1286.4" "726.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "78.451" "22" "12" "19" "12" "498" "54.3" "5.53" "73.86" "12" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Regulation of actin cytoskeleton" "8" "0" "0.951" "0.933" "0.935" "0.901" "0.866" "0.936" "0.961" "0.945" "0.660" "2147.6" "2042.9" "2002.9" "2007.9" "1933.9" "1860.6" "2009.2" "2063.6" "2028.7" "1417.7" "" "" "" "" "" "" "" "" "" "" "1904.4" "1692.2" "1747.6" "1501.6" "1612.6" "1709.2" "1698.1" "1705.7" "1860.6" "1417.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "78.416" "66" "12" "24" "12" "154" "17.5" "6.11" "94.57" "12" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "0.924" "0.985" "0.945" "0.974" "0.981" "0.929" "1.038" "0.987" "0.455" "2581.0" "2384.2" "2542.5" "2439.1" "2514.7" "2532.3" "2396.6" "2680.1" "2548.1" "1174.1" "" "" "" "" "" "" "" "" "" "" "2288.7" "1975.0" "2218.4" "1824.1" "2096.9" "2326.2" "2025.5" "2215.3" "2337.0" "1174.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7228226931451830335" "False" "High" "IsMasterProtein" "O15084" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5" "0.000" "False" "78.376" "15" "11" "14" "9" "1053" "112.9" "6.25" "59.62" "11" "" "cytosol;nucleus" "" "Pf00023, Pf12796" "23243" "ENSG00000206560" "ANKRD28" "B4DES5; hsa:23243; O15084; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "2" "0.985" "0.960" "0.999" "0.993" "0.880" "0.945" "0.969" "0.902" "0.993" "1092.3" "1075.6" "1048.8" "1090.7" "1085.0" "961.1" "1032.1" "1057.9" "985.5" "1084.7" "" "" "" "" "" "" "" "" "" "" "968.6" "891.0" "915.1" "815.7" "904.8" "882.9" "872.3" "874.5" "903.8" "1084.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "78.357" "35" "6" "27" "6" "199" "21.5" "5.24" "127.25" "6" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "1.004" "1.006" "1.010" "1.009" "1.025" "0.962" "1.052" "1.064" "0.518" "2973.8" "2985.5" "2991.7" "3002.1" "3001.3" "3049.1" "2861.3" "3129.6" "3165.1" "1539.2" "" "" "" "" "" "" "" "" "" "" "2637.1" "2473.0" "2610.4" "2245.2" "2502.7" "2801.0" "2418.3" "2586.8" "2902.8" "1539.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193140464994973163" "False" "High" "IsMasterProtein" "P49711" "Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1" "0.000" "False" "78.233" "19" "13" "27" "13" "727" "82.7" "6.96" "88.52" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10664" "ENSG00000102974" "CTCF" "B5MC38; hsa:10664; P49711; Q53XI7; Q59EL8" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "MECP2 and associated Rett syndrome; Prion disease pathway; Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "0.967" "1.003" "0.982" "0.901" "0.851" "0.831" "0.908" "0.964" "0.596" "1833.1" "1772.7" "1838.3" "1800.1" "1651.1" "1559.6" "1522.9" "1664.6" "1767.0" "1091.7" "" "" "" "" "" "" "" "" "" "" "1625.6" "1468.4" "1604.0" "1346.2" "1376.8" "1432.7" "1287.1" "1375.9" "1620.6" "1091.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.000" "False" "78.214" "15" "15" "18" "15" "1224" "136.6" "6.92" "70.33" "15" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "RHOH GTPase cycle" "" "1" "0" "0.953" "0.918" "0.993" "0.918" "0.897" "0.923" "0.870" "0.847" "0.903" "2088.6" "1991.0" "1917.5" "2073.3" "1918.3" "1874.3" "1928.6" "1816.7" "1769.3" "1886.5" "" "" "" "" "" "" "" "" "" "" "1852.2" "1649.2" "1673.1" "1550.6" "1599.6" "1721.8" "1630.0" "1501.6" "1622.7" "1886.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "High" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.000" "False" "78.042" "14" "15" "16" "15" "1328" "149.2" "6.74" "62.87" "15" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "5" "0" "0.934" "0.924" "0.984" "0.935" "0.870" "0.909" "0.628" "0.892" "5.905" "792.7" "740.0" "732.8" "779.9" "741.5" "690.0" "720.6" "497.5" "707.2" "4680.6" "" "" "" "" "" "" "" "" "" "" "703.0" "613.0" "639.4" "583.3" "618.3" "633.8" "609.0" "411.2" "648.6" "4680.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.000" "False" "77.850" "51" "8" "15" "8" "211" "23.3" "5.01" "65.78" "8" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "Insulin signaling" "13" "0" "1.036" "0.963" "1.051" "0.994" "0.970" "1.017" "1.000" "1.057" "0.543" "1825.8" "1892.3" "1759.1" "1918.9" "1814.8" "1771.1" "1856.8" "1826.6" "1930.0" "991.6" "" "" "" "" "" "" "" "" "" "" "1619.1" "1567.5" "1534.9" "1435.0" "1513.3" "1626.9" "1569.3" "1509.8" "1770.0" "991.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "77.825" "37" "15" "21" "15" "382" "43.9" "7.46" "85.65" "15" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.026" "1.010" "0.975" "0.966" "1.019" "0.950" "0.919" "0.925" "1.852" "3332.3" "3419.9" "3364.7" "3250.6" "3218.0" "3396.8" "3164.7" "3061.8" "3080.8" "6172.8" "" "" "" "" "" "" "" "" "" "" "2955.0" "2832.9" "2935.9" "2431.0" "2683.4" "3120.4" "2674.6" "2530.8" "2825.5" "6172.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "77.727" "31" "13" "21" "13" "456" "52.1" "6.21" "78.39" "13" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "Processing of Capped Intron-Containing Pre-mRNA" "1p36 copy number variation syndrome" "2" "0" "0.941" "0.951" "0.963" "0.956" "0.998" "0.958" "1.017" "0.966" "0.559" "2576.9" "2424.3" "2450.6" "2480.6" "2464.7" "2570.9" "2469.4" "2620.9" "2489.7" "1441.0" "" "" "" "" "" "" "" "" "" "" "2285.1" "2008.2" "2138.2" "1855.2" "2055.2" "2361.6" "2087.0" "2166.3" "2283.4" "1441.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "77.700" "52" "12" "28" "12" "212" "23.8" "8.27" "96.71" "12" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "3" "0" "0.969" "0.990" "1.021" "0.991" "0.985" "1.026" "1.052" "0.967" "0.508" "3655.7" "3541.3" "3618.5" "3732.4" "3624.5" "3600.7" "3751.9" "3844.9" "3534.5" "1857.5" "" "" "" "" "" "" "" "" "" "" "3241.8" "2933.4" "3157.4" "2791.3" "3022.4" "3307.7" "3171.0" "3178.1" "3241.6" "1857.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "77.495" "51" "6" "28" "6" "144" "16.6" "7.81" "106.58" "6" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "0.932" "0.946" "0.930" "0.927" "0.953" "0.935" "0.977" "0.903" "0.439" "4192.4" "3908.1" "3965.2" "3898.7" "3885.6" "3995.7" "3918.7" "4094.7" "3783.8" "1840.9" "" "" "" "" "" "" "" "" "" "" "3717.7" "3237.3" "3459.8" "2915.7" "3240.0" "3670.5" "3311.9" "3384.6" "3470.3" "1840.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "77.488" "38" "9" "28" "9" "204" "23.2" "5.11" "101.24" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "12" "0" "1.107" "1.120" "1.005" "1.125" "1.109" "1.043" "1.049" "1.103" "0.805" "3867.7" "4281.2" "4332.1" "3886.7" "4349.3" "4287.7" "4034.7" "4055.3" "4266.3" "3113.4" "" "" "" "" "" "" "" "" "" "" "3429.8" "3546.3" "3780.0" "2906.7" "3626.7" "3938.8" "3410.0" "3352.0" "3912.7" "3113.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "77.475" "56" "10" "19" "10" "244" "26.7" "9.17" "69.49" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.012" "1.002" "0.991" "1.034" "1.084" "1.037" "0.988" "0.891" "0.390" "1581.3" "1600.8" "1584.4" "1566.7" "1635.1" "1713.9" "1639.4" "1563.1" "1409.2" "616.7" "" "" "" "" "" "" "" "" "" "" "1402.3" "1326.0" "1382.5" "1171.7" "1363.4" "1574.4" "1385.5" "1292.0" "1292.4" "616.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "77.416" "15" "17" "20" "12" "1105" "122.8" "5.76" "68.08" "17" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "1.027" "0.966" "1.009" "0.963" "0.987" "0.925" "0.693" "0.985" "5.364" "1223.0" "1255.5" "1181.2" "1233.5" "1177.5" "1207.4" "1131.3" "847.3" "1204.6" "6560.7" "" "" "" "" "" "" "" "" "" "" "1084.6" "1040.0" "1030.7" "922.5" "981.9" "1109.1" "956.1" "700.3" "1104.8" "6560.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "77.357" "23" "6" "95" "6" "111" "12.2" "3.78" "318.86" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.013" "0.970" "1.142" "1.042" "1.177" "0.907" "1.022" "1.018" "0.484" "8686.3" "8800.4" "8424.2" "9918.7" "9052.7" "10223.3" "7877.1" "8877.1" "8845.4" "4202.3" "" "" "" "" "" "" "" "" "" "" "7702.8" "7289.8" "7350.5" "7417.9" "7548.8" "9391.2" "6657.4" "7337.6" "8112.5" "4202.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1707111681236337832" "False" "High" "IsMasterProtein" "Q96BY7" "Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5" "0.000" "False" "77.351" "9" "19" "23" "18" "2078" "232.6" "5.76" "69.91" "19" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624, Pf13329" "55102" "ENSG00000066739" "ATG2B" "hsa:55102; Q6ZRE7; Q96BY7; Q96DQ3; Q9NW80" "" "Alzheimer's disease and miRNA effects; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Alzheimer's disease" "3" "1" "1.043" "1.027" "1.012" "1.084" "0.988" "1.034" "1.011" "1.001" "0.782" "1597.9" "1666.9" "1641.2" "1617.5" "1731.9" "1579.3" "1651.5" "1616.0" "1599.7" "1249.5" "" "" "" "" "" "" "" "" "" "" "1417.0" "1380.8" "1432.0" "1209.7" "1444.2" "1450.8" "1395.8" "1335.7" "1467.2" "1249.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "77.077" "20" "13" "17" "13" "805" "90.3" "5.40" "60.18" "13" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "6" "0" "1.001" "0.928" "1.115" "0.942" "0.909" "0.972" "0.522" "0.992" "9.036" "409.6" "409.9" "380.3" "456.7" "385.7" "372.5" "398.1" "213.8" "406.3" "3701.4" "" "" "" "" "" "" "" "" "" "" "363.2" "339.5" "331.8" "341.5" "321.7" "342.2" "336.5" "176.7" "372.6" "3701.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "77.033" "37" "9" "17" "9" "322" "35.5" "5.48" "69.71" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Regulation of HSF1-mediated heat shock response; Separation of Sister Chromatids; HCMV Late Events; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Postmitotic nuclear pore complex (NPC) reformation" "Sterol regulatory element-binding proteins (SREBP) signaling" "40" "0" "1.016" "1.053" "1.087" "1.033" "1.035" "1.063" "1.039" "0.972" "1.111" "1458.8" "1482.0" "1535.9" "1585.9" "1506.2" "1510.0" "1550.5" "1515.6" "1418.2" "1621.0" "" "" "" "" "" "" "" "" "" "" "1293.7" "1227.6" "1340.2" "1186.1" "1256.0" "1387.1" "1310.4" "1252.8" "1300.6" "1621.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "77.031" "31" "13" "20" "12" "517" "59.1" "5.97" "76.49" "13" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "1" "1.035" "1.077" "1.054" "1.097" "1.049" "1.032" "1.029" "0.921" "0.503" "753.8" "780.4" "811.9" "794.5" "826.6" "790.6" "777.7" "776.0" "694.5" "379.4" "" "" "" "" "" "" "" "" "" "" "668.4" "646.4" "708.4" "594.2" "689.3" "726.2" "657.3" "641.4" "636.9" "379.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5793722554403523201" "False" "High" "IsMasterProtein" "Q14764" "Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4" "0.000" "False" "76.817" "17" "13" "16" "13" "893" "99.3" "5.48" "63.06" "13" "transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01505, Pf11978, Pf17794, Pf17795, Pf17796" "9961" "ENSG00000013364" "MVP" "hsa:9961; Q14764; Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1" "Neutrophil degranulation" "16p11.2 proximal deletion syndrome" "2" "0" "1.037" "0.906" "1.217" "1.043" "0.980" "1.118" "1.043" "1.087" "1.214" "1950.9" "2022.7" "1768.2" "2374.3" "2034.1" "1911.4" "2180.3" "2035.5" "2120.3" "2368.1" "" "" "" "" "" "" "" "" "" "" "1730.0" "1675.5" "1542.9" "1775.7" "1696.2" "1755.8" "1842.7" "1682.4" "1944.6" "2368.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.000" "False" "76.731" "40" "12" "17" "12" "369" "39.2" "9.83" "63.54" "12" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "2" "0" "1.040" "0.983" "1.080" "1.051" "0.981" "1.153" "1.076" "1.002" "0.636" "1279.0" "1330.1" "1257.9" "1381.9" "1343.7" "1254.6" "1474.1" "1376.1" "1281.8" "813.1" "" "" "" "" "" "" "" "" "" "" "1134.2" "1101.8" "1097.5" "1033.5" "1120.4" "1152.5" "1245.8" "1137.5" "1175.5" "813.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "76.708" "34" "16" "18" "16" "494" "56.4" "6.96" "61.89" "16" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Regulation of HSF1-mediated heat shock response" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "4" "0" "0.954" "0.914" "0.960" "0.887" "0.891" "0.963" "0.242" "0.994" "14.765" "529.8" "505.3" "484.5" "508.8" "469.8" "472.0" "510.0" "128.2" "526.6" "7822.8" "" "" "" "" "" "" "" "" "" "" "469.8" "418.6" "422.7" "380.5" "391.8" "433.6" "431.1" "105.9" "483.0" "7822.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "76.621" "11" "20" "21" "20" "1830" "211.8" "6.87" "67.91" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "Neutrophil degranulation; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "Chemokine signaling pathway" "8" "0" "1.028" "0.910" "1.032" "0.969" "0.919" "0.960" "0.514" "0.933" "8.436" "606.2" "623.2" "551.7" "625.6" "587.2" "557.3" "581.8" "311.7" "565.9" "5114.5" "" "" "" "" "" "" "" "" "" "" "537.6" "516.3" "481.4" "467.8" "489.6" "511.9" "491.7" "257.7" "519.0" "5114.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "High" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.000" "False" "76.538" "21" "8" "15" "8" "535" "59.8" "5.08" "68.65" "8" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "Nuclear Receptor transcription pathway" "" "1" "0" "1.109" "1.056" "1.132" "1.122" "1.099" "1.098" "1.127" "1.000" "0.962" "1166.7" "1293.8" "1231.9" "1320.5" "1309.0" "1281.9" "1281.6" "1314.2" "1166.3" "1122.2" "" "" "" "" "" "" "" "" "" "" "1034.6" "1071.7" "1074.9" "987.5" "1091.5" "1177.5" "1083.1" "1086.3" "1069.6" "1122.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7220942742966589684" "False" "High" "IsMasterProtein" "P01130" "Low-density lipoprotein receptor OS=Homo sapiens OX=9606 GN=LDLR PE=1 SV=1" "0.000" "False" "76.494" "21" "16" "23" "15" "860" "95.3" "5.05" "78.12" "16" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00057, Pf00058, Pf14670" "3949" "ENSG00000130164" "LDLR" "B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7; hsa:3949; P01130; Q53ZD9; Q59FQ1; Q9UDH7" "Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Cholesterol metabolism; Enterocyte cholesterol metabolism; DNA damage response (only ATM dependent)" "27" "0" "0.983" "0.951" "1.007" "0.951" "0.940" "0.862" "0.869" "0.851" "0.640" "1858.6" "1827.2" "1767.4" "1872.3" "1767.6" "1747.8" "1602.5" "1615.5" "1581.0" "1190.3" "" "" "" "" "" "" "" "" "" "" "1648.1" "1513.6" "1542.1" "1400.3" "1473.9" "1605.6" "1354.4" "1335.3" "1450.0" "1190.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492366251309725518" "False" "High" "IsMasterProtein" "Q9BZ23" "Pantothenate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PANK2 PE=1 SV=3" "0.000" "False" "76.483" "18" "8" "10" "4" "570" "62.6" "9.28" "51.05" "8" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf03630" "80025" "ENSG00000125779" "PANK2" "B1AK33; B2Z3X0; D3DVZ0; hsa:80025; Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9BZ23; Q9HAF2" "Coenzyme A biosynthesis" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "3" "0" "1.096" "1.081" "1.081" "1.154" "1.120" "1.090" "1.126" "1.081" "0.838" "586.4" "642.5" "633.8" "634.1" "676.7" "657.0" "639.3" "660.0" "633.9" "491.4" "" "" "" "" "" "" "" "" "" "" "520.0" "532.2" "553.0" "474.2" "564.3" "603.5" "540.3" "545.6" "581.4" "491.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3054856418516569750" "False" "High" "IsMasterProtein" "Q8IZ07" "Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3" "0.000" "False" "76.441" "25" "12" "17" "12" "590" "67.6" "5.02" "63.98" "12" "other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11904, Pf12796" "88455" "ENSG00000076513" "ANKRD13A" "hsa:88455; O60736; Q8IZ07" "" "" "0" "0" "0.972" "0.849" "1.005" "0.845" "0.821" "0.975" "0.792" "0.788" "1.376" "1488.9" "1447.4" "1264.8" "1496.0" "1257.4" "1223.0" "1451.8" "1178.8" "1173.8" "2049.1" "" "" "" "" "" "" "" "" "" "" "1320.3" "1199.0" "1103.6" "1118.8" "1048.5" "1123.5" "1227.0" "974.4" "1076.5" "2049.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1274747088330592999" "False" "High" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "0.000" "False" "76.424" "16" "14" "19" "4" "939" "103.9" "6.96" "66.40" "14" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "18" "0" "1.030" "0.920" "1.023" "1.041" "1.014" "1.034" "0.980" "0.923" "0.815" "523.7" "539.3" "481.9" "535.5" "545.1" "530.8" "541.7" "513.3" "483.4" "427.0" "" "" "" "" "" "" "" "" "" "" "464.4" "446.7" "420.5" "400.5" "454.6" "487.6" "457.8" "424.3" "443.3" "427.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656538987652310722" "False" "High" "IsMasterProtein" "Q86X29" "Lipolysis-stimulated lipoprotein receptor OS=Homo sapiens OX=9606 GN=LSR PE=1 SV=4" "0.000" "False" "76.409" "23" "12" "18" "12" "649" "71.4" "7.97" "71.88" "12" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "" "Pf05624" "51599" "ENSG00000105699" "LSR" "A6NDW3; B4DKL4; E9PHD4; hsa:51599; O00112; O00426; Q6ZT80; Q86X29; Q8NBM0; Q9BT33; Q9UQL3" "LDL clearance; VLDL clearance" "" "2" "0" "1.012" "0.962" "0.977" "0.970" "0.974" "0.979" "0.962" "1.060" "0.478" "1759.5" "1781.1" "1693.5" "1719.4" "1706.4" "1712.9" "1723.3" "1693.0" "1864.7" "841.7" "" "" "" "" "" "" "" "" "" "" "1560.3" "1475.4" "1477.6" "1285.9" "1422.9" "1573.5" "1456.4" "1399.4" "1710.2" "841.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "76.357" "32" "11" "23" "11" "299" "33.6" "4.81" "89.98" "11" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "0.910" "0.830" "0.825" "0.744" "0.702" "0.641" "0.777" "0.783" "0.386" "3414.2" "3107.2" "2833.5" "2815.7" "2540.8" "2398.1" "2188.4" "2652.5" "2674.2" "1318.0" "" "" "" "" "" "" "" "" "" "" "3027.6" "2573.8" "2472.4" "2105.8" "2118.7" "2202.9" "1849.5" "2192.5" "2452.6" "1318.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "76.355" "36" "13" "29" "7" "416" "46.5" "5.29" "76.23" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "Apoptotic cleavage of cellular proteins" "" "1" "1" "0.979" "0.982" "1.063" "1.084" "1.078" "1.220" "0.982" "1.199" "3.339" "292.4" "286.1" "287.0" "310.8" "317.0" "315.3" "356.6" "287.2" "350.6" "976.3" "" "" "" "" "" "" "" "" "" "" "259.3" "237.0" "250.4" "232.5" "264.4" "289.6" "301.4" "237.4" "321.6" "976.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.000" "False" "76.263" "22" "17" "19" "17" "812" "89.0" "8.44" "68.42" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "1.016" "1.025" "0.980" "1.002" "1.015" "0.999" "0.990" "1.055" "1.242" "1570.9" "1595.8" "1610.4" "1539.2" "1574.9" "1593.8" "1569.6" "1556.0" "1657.0" "1950.6" "" "" "" "" "" "" "" "" "" "" "1393.1" "1321.8" "1405.2" "1151.1" "1313.2" "1464.1" "1326.6" "1286.1" "1519.7" "1950.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "76.263" "32" "11" "27" "11" "331" "37.5" "8.34" "96.49" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "MHC class II antigen presentation; Neutrophil degranulation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "" "6" "0" "0.965" "0.998" "0.922" "0.927" "1.047" "0.864" "0.952" "0.962" "0.562" "4540.1" "4381.9" "4530.9" "4184.9" "4208.7" "4755.4" "3922.4" "4322.0" "4365.8" "2552.8" "" "" "" "" "" "" "" "" "" "" "4026.1" "3629.8" "3953.4" "3129.8" "3509.5" "4368.4" "3315.1" "3572.4" "4004.1" "2552.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.000" "False" "76.228" "29" "14" "20" "14" "531" "59.7" "5.40" "78.15" "14" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "" "IL-18 signaling pathway" "1" "0" "0.949" "0.923" "0.935" "0.912" "0.973" "0.871" "0.882" "0.854" "0.619" "1969.6" "1869.8" "1818.3" "1841.8" "1795.9" "1916.7" "1714.9" "1738.0" "1681.4" "1218.2" "" "" "" "" "" "" "" "" "" "" "1746.6" "1548.8" "1586.5" "1377.4" "1497.5" "1760.7" "1449.4" "1436.6" "1542.1" "1218.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1890779364620067180" "False" "High" "IsMasterProtein" "Q96CD2" "Phosphopantothenoylcysteine decarboxylase OS=Homo sapiens OX=9606 GN=PPCDC PE=1 SV=2" "0.000" "False" "76.139" "43" "7" "13" "7" "204" "22.4" "6.10" "50.65" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02441" "60490" "ENSG00000138621" "PPCDC" "hsa:60490; Q96CD2; Q96SX0; Q9HC17" "Coenzyme A biosynthesis" "" "1" "0" "1.024" "1.036" "1.030" "1.037" "1.043" "1.061" "0.996" "1.071" "0.738" "1259.7" "1289.6" "1305.5" "1296.8" "1306.1" "1313.7" "1336.3" "1255.0" "1349.6" "929.1" "" "" "" "" "" "" "" "" "" "" "1117.1" "1068.3" "1139.1" "969.9" "1089.1" "1206.8" "1129.4" "1037.3" "1237.8" "929.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "76.100" "38" "11" "16" "11" "415" "46.7" "6.81" "77.52" "11" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.028" "1.101" "1.065" "1.142" "1.058" "1.058" "1.037" "1.013" "0.606" "1940.9" "1996.2" "2136.6" "2066.2" "2217.4" "2053.9" "2054.1" "2012.2" "1965.8" "1176.4" "" "" "" "" "" "" "" "" "" "" "1721.2" "1653.5" "1864.3" "1545.3" "1849.0" "1886.7" "1736.1" "1663.2" "1802.9" "1176.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629403927496459035" "False" "High" "IsMasterProtein" "P62987" "Ubiquitin-ribosomal protein eL40 fusion protein OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2" "0.000" "False" "76.092" "59" "10" "243" "1" "128" "14.7" "9.83" "773.04" "10" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01020" "7311" "ENSG00000221983" "UBA52" "hsa:7311; P02248; P02249; P02250; P14793; P62987; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "Major pathway of rRNA processing in the nucleolus and cytosol; Membrane binding and targetting of GAG proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Peroxisomal protein import; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PLK1 Activity at G2/M Transition; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Ovarian tumor domain proteases; Regulation of signaling by CBL; Signaling by CSF1 (M-CSF) in myeloid cells; FCERI mediated NF-kB activation; Cyclin D associated events in G1; Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Regulation of innate immune responses to cytosolic DNA; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; MAP3K8 (TPL2)-dependent MAPK1/3 activation; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Metalloprotease DUBs; Regulation of necroptotic cell death; APC-Cdc20 mediated degradation of Nek2A; Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; HDR through Homologous Recombination (HRR); TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "DNA replication; Cytoplasmic ribosomal proteins" "199" "0" "0.931" "1.010" "0.832" "1.069" "1.248" "0.928" "0.987" "1.047" "0.319" "181.2" "168.7" "183.0" "150.7" "193.6" "226.1" "168.2" "178.9" "189.8" "57.8" "" "" "" "" "" "" "" "" "" "" "160.7" "139.8" "159.7" "112.7" "161.5" "207.7" "142.1" "147.9" "174.0" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "76.074" "52" "11" "22" "11" "219" "24.3" "6.21" "84.88" "11" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "" "3" "0" "1.090" "1.018" "1.067" "1.051" "1.075" "1.061" "1.069" "0.948" "1.553" "1781.4" "1941.2" "1813.2" "1900.7" "1872.6" "1915.8" "1890.4" "1904.5" "1689.2" "2766.3" "" "" "" "" "" "" "" "" "" "" "1579.7" "1608.0" "1582.1" "1421.5" "1561.5" "1759.9" "1597.7" "1574.2" "1549.2" "2766.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "76.026" "51" "10" "33" "10" "183" "20.9" "7.69" "121.33" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; TGF-beta receptor signaling activates SMADs" "" "5" "0" "0.971" "1.001" "0.911" "0.903" "0.884" "0.944" "0.944" "0.977" "1.363" "4084.1" "3963.7" "4089.0" "3722.4" "3688.9" "3611.4" "3854.5" "3855.9" "3988.7" "5565.7" "" "" "" "" "" "" "" "" "" "" "3621.7" "3283.4" "3567.8" "2783.9" "3076.1" "3317.4" "3257.7" "3187.1" "3658.2" "5565.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3824226989303919527" "False" "High" "IsMasterProtein" "Q68EM7" "Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1" "0.000" "False" "75.983" "17" "14" "19" "14" "881" "95.4" "7.62" "70.34" "14" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "55114" "ENSG00000140750; ENSG00000288353" "ARHGAP17" "A8K6M6; hsa:55114; Q68EM7; Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "" "6" "0" "1.060" "1.007" "1.057" "1.007" "0.955" "1.016" "0.435" "1.052" "10.525" "733.0" "777.2" "737.9" "775.1" "737.8" "699.9" "744.9" "318.9" "770.8" "7714.5" "" "" "" "" "" "" "" "" "" "" "650.0" "643.8" "643.8" "579.7" "615.2" "643.0" "629.5" "263.6" "707.0" "7714.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "75.971" "23" "11" "13" "11" "635" "72.0" "8.25" "55.36" "11" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "Potential therapeutics for SARS; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Integrin signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "30" "0" "1.050" "0.939" "1.045" "1.025" "1.053" "1.072" "0.350" "1.079" "15.686" "478.4" "502.5" "449.3" "500.0" "490.6" "503.9" "512.8" "167.2" "516.0" "7505.1" "" "" "" "" "" "" "" "" "" "" "424.3" "416.3" "392.1" "373.9" "409.1" "462.9" "433.4" "138.2" "473.3" "7505.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "75.887" "18" "18" "23" "18" "940" "99.0" "9.17" "57.66" "18" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "0.915" "0.889" "0.764" "0.797" "0.695" "0.656" "0.726" "0.814" "0.808" "1742.6" "1593.9" "1549.8" "1330.5" "1388.0" "1210.9" "1142.9" "1264.3" "1418.7" "1408.8" "" "" "" "" "" "" "" "" "" "" "1545.3" "1320.3" "1352.3" "995.0" "1157.4" "1112.4" "965.9" "1045.0" "1301.1" "1408.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "75.782" "42" "6" "30" "6" "127" "14.4" "9.60" "124.70" "6" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "0.947" "0.946" "0.936" "0.943" "0.941" "0.938" "0.953" "0.941" "0.448" "3469.9" "3284.6" "3283.3" "3248.3" "3273.7" "3264.3" "3254.3" "3306.6" "3266.3" "1554.4" "" "" "" "" "" "" "" "" "" "" "3077.0" "2720.8" "2864.9" "2429.3" "2729.8" "2998.6" "2750.4" "2733.1" "2995.7" "1554.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7061207721996529093" "False" "High" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "0.000" "False" "75.751" "40" "13" "22" "13" "320" "35.9" "5.05" "73.93" "13" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Platelet degranulation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "4" "0" "0.950" "0.985" "0.964" "0.906" "0.867" "0.969" "0.623" "0.940" "6.726" "1992.3" "1891.7" "1963.1" "1921.2" "1804.9" "1727.0" "1930.8" "1240.3" "1873.7" "13399.9" "" "" "" "" "" "" "" "" "" "" "1766.7" "1567.0" "1712.9" "1436.8" "1505.0" "1586.5" "1631.8" "1025.2" "1718.4" "13399.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "75.733" "28" "9" "23" "9" "404" "44.8" "4.84" "87.32" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.028" "1.113" "1.048" "1.143" "1.115" "1.216" "1.285" "1.245" "0.745" "1379.0" "1417.7" "1534.3" "1445.3" "1575.9" "1537.8" "1676.9" "1772.3" "1716.6" "1027.2" "" "" "" "" "" "" "" "" "" "" "1222.9" "1174.4" "1338.8" "1080.9" "1314.1" "1412.6" "1417.2" "1464.9" "1574.4" "1027.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634316393020217319" "False" "High" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "0.000" "False" "75.646" "22" "15" "25" "15" "725" "83.6" "7.05" "83.43" "15" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.964" "0.901" "1.018" "0.898" "0.930" "1.059" "0.993" "0.962" "1.051" "876.4" "844.9" "790.0" "892.1" "787.1" "814.7" "927.8" "870.4" "843.4" "921.1" "" "" "" "" "" "" "" "" "" "" "777.2" "699.9" "689.3" "667.2" "656.3" "748.4" "784.1" "719.5" "773.5" "921.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "75.628" "19" "9" "16" "5" "521" "57.8" "4.94" "71.65" "9" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "" "2" "2" "1.045" "1.009" "1.082" "1.066" "1.092" "0.973" "0.982" "0.881" "1.589" "2331.1" "2436.8" "2351.7" "2521.6" "2486.0" "2546.7" "2267.1" "2290.0" "2054.2" "3703.5" "" "" "" "" "" "" "" "" "" "" "2067.1" "2018.5" "2051.9" "1885.8" "2073.0" "2339.4" "1916.1" "1892.9" "1884.0" "3703.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7883409800749118824" "False" "High" "IsMasterProtein" "Q7KZ85" "Transcription elongation factor SPT6 OS=Homo sapiens OX=9606 GN=SUPT6H PE=1 SV=2" "0.000" "False" "75.600" "10" "14" "18" "14" "1726" "198.9" "4.91" "60.41" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00575, Pf14632, Pf14633, Pf14635, Pf14639, Pf14641, Pf17674" "6830" "ENSG00000109111" "SUPT6H" "A7E2B4; hsa:6830; Q15737; Q6GMQ4; Q7KYW9; Q7KZ85; Q7LDK4; Q8N526; Q92775; Q96AH3; Q9BTH9; Q9BTI2" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "1.036" "0.985" "1.024" "0.928" "0.997" "1.033" "0.597" "0.954" "7.888" "618.0" "640.4" "608.4" "633.1" "573.6" "615.9" "638.5" "369.1" "589.6" "4874.7" "" "" "" "" "" "" "" "" "" "" "548.0" "530.5" "530.9" "473.5" "478.3" "565.8" "539.7" "305.1" "540.8" "4874.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "75.562" "32" "12" "17" "12" "425" "48.0" "4.81" "66.26" "12" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "0.939" "0.996" "0.922" "0.883" "0.973" "0.950" "0.986" "1.044" "1.214" "2496.0" "2344.9" "2486.7" "2300.8" "2203.7" "2427.8" "2371.6" "2460.2" "2604.7" "3030.9" "" "" "" "" "" "" "" "" "" "" "2213.4" "1942.4" "2169.8" "1720.7" "1837.6" "2230.2" "2004.3" "2033.6" "2388.9" "3030.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "75.468" "24" "17" "24" "15" "668" "75.0" "9.66" "83.03" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in progeria" "7" "1" "0.939" "1.005" "0.954" "0.900" "0.910" "0.923" "0.784" "1.030" "3.413" "1359.9" "1276.8" "1366.5" "1297.5" "1223.7" "1237.5" "1255.1" "1066.3" "1400.6" "4641.2" "" "" "" "" "" "" "" "" "" "" "1205.9" "1057.6" "1192.4" "970.4" "1020.4" "1136.8" "1060.7" "881.3" "1284.5" "4641.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "High" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.000" "False" "75.447" "35" "10" "15" "10" "259" "30.1" "5.34" "59.70" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "Neddylation" "" "1" "0" "0.968" "1.022" "0.936" "0.969" "0.948" "0.932" "0.995" "0.988" "0.851" "2368.8" "2293.1" "2422.0" "2216.3" "2295.8" "2244.7" "2206.7" "2356.5" "2340.9" "2016.7" "" "" "" "" "" "" "" "" "" "" "2100.6" "1899.5" "2113.3" "1657.5" "1914.4" "2062.0" "1865.0" "1947.9" "2147.0" "2016.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "75.371" "45" "12" "24" "12" "254" "28.9" "5.45" "90.14" "12" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "0.907" "0.867" "0.879" "0.884" "0.803" "0.791" "0.893" "0.913" "0.463" "3892.9" "3530.6" "3375.7" "3421.4" "3443.0" "3127.2" "3077.7" "3477.4" "3554.8" "1803.2" "" "" "" "" "" "" "" "" "" "" "3452.1" "2924.6" "2945.4" "2558.7" "2871.0" "2872.7" "2601.2" "2874.3" "3260.2" "1803.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "75.351" "35" "10" "18" "10" "359" "38.4" "5.50" "71.75" "10" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "4" "0" "1.082" "1.054" "0.795" "1.190" "0.902" "1.116" "1.094" "0.815" "0.478" "1886.1" "2041.2" "1987.5" "1499.6" "2243.8" "1700.6" "2105.0" "2063.6" "1537.5" "902.1" "" "" "" "" "" "" "" "" "" "" "1672.5" "1690.8" "1734.2" "1121.5" "1871.0" "1562.1" "1779.1" "1705.7" "1410.1" "902.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "75.301" "33" "9" "27" "9" "222" "24.7" "8.25" "107.00" "9" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "10" "0" "0.939" "1.018" "0.970" "1.027" "1.058" "1.024" "1.095" "1.020" "0.372" "3299.5" "3099.5" "3357.9" "3200.5" "3390.2" "3490.6" "3378.8" "3613.0" "3366.0" "1226.0" "" "" "" "" "" "" "" "" "" "" "2926.0" "2567.4" "2929.9" "2393.5" "2827.0" "3206.5" "2855.7" "2986.4" "3087.1" "1226.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3677224009341935597" "False" "High" "IsMasterProtein" "P48729" "Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2" "0.000" "False" "75.244" "31" "9" "12" "9" "337" "38.9" "9.57" "54.33" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1452" "ENSG00000113712" "CSNK1A1" "D3DQG0; D3DQG1; hsa:1452; P48729; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein" "Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development" "32" "0" "0.963" "0.960" "1.048" "1.031" "1.037" "1.039" "1.002" "0.905" "1.474" "1115.5" "1073.7" "1071.3" "1168.7" "1150.2" "1156.3" "1159.3" "1117.6" "1009.2" "1643.8" "" "" "" "" "" "" "" "" "" "" "989.2" "889.4" "934.8" "874.0" "959.1" "1062.2" "979.8" "923.7" "925.5" "1643.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "75.204" "53" "9" "19" "9" "230" "26.2" "4.92" "79.25" "9" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "UCH proteinases; Neddylation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "Proteasome degradation" "4" "0" "1.039" "1.067" "0.942" "0.989" "1.052" "0.988" "1.021" "1.088" "0.877" "2255.6" "2343.5" "2406.3" "2123.8" "2230.6" "2372.7" "2228.0" "2303.7" "2454.6" "1979.1" "" "" "" "" "" "" "" "" "" "" "2000.2" "1941.3" "2099.6" "1588.3" "1860.0" "2179.6" "1883.1" "1904.1" "2251.2" "1979.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "75.186" "16" "15" "21" "14" "955" "108.6" "10.15" "69.49" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "Interactome of polycomb repressive complex 2 (PRC2)" "3" "1" "1.070" "1.048" "1.053" "1.004" "1.059" "0.938" "1.067" "1.057" "0.771" "2439.2" "2610.5" "2557.0" "2569.5" "2448.0" "2584.2" "2287.4" "2601.8" "2579.2" "1881.4" "" "" "" "" "" "" "" "" "" "" "2163.0" "2162.4" "2231.1" "1921.6" "2041.3" "2373.9" "1933.3" "2150.6" "2365.5" "1881.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4229859227879041997" "False" "High" "IsMasterProtein" "P16278" "Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2" "0.000" "False" "75.165" "16" "9" "16" "9" "677" "76.0" "6.57" "62.65" "9" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01301, Pf21317, Pf21467" "2720" "ENSG00000170266" "GLB1" "B2R7H8; B7Z6B0; hsa:2720; P16278; P16279" "Neutrophil degranulation; HS-GAG degradation; Sialic acid metabolism; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B" "Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence" "12" "0" "1.166" "1.054" "1.121" "1.189" "1.165" "1.127" "1.109" "1.024" "0.657" "1421.7" "1658.1" "1499.1" "1594.3" "1691.1" "1656.1" "1602.0" "1576.9" "1456.5" "934.1" "" "" "" "" "" "" "" "" "" "" "1260.7" "1373.5" "1308.0" "1192.3" "1410.1" "1521.3" "1353.9" "1303.4" "1335.8" "934.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "75.134" "27" "8" "19" "8" "352" "39.9" "6.54" "89.08" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "10" "0" "0.962" "0.998" "0.905" "0.980" "0.998" "0.966" "0.886" "0.965" "1.533" "1771.1" "1703.0" "1767.1" "1602.2" "1735.2" "1767.1" "1711.2" "1569.5" "1709.1" "2715.9" "" "" "" "" "" "" "" "" "" "" "1570.6" "1410.7" "1541.9" "1198.2" "1447.0" "1623.3" "1446.3" "1297.3" "1567.5" "2715.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "75.102" "37" "10" "19" "10" "278" "30.7" "5.49" "80.79" "10" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "Trafficking and processing of endosomal TLR" "" "1" "0" "0.972" "1.007" "0.939" "0.937" "1.061" "0.955" "0.985" "1.024" "0.449" "2717.5" "2642.4" "2736.9" "2551.3" "2545.9" "2883.6" "2595.2" "2677.4" "2783.6" "1219.8" "" "" "" "" "" "" "" "" "" "" "2409.8" "2188.9" "2388.1" "1908.0" "2122.9" "2648.9" "2193.3" "2213.1" "2553.0" "1219.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "74.976" "21" "20" "23" "20" "916" "102.8" "4.91" "78.69" "20" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "0.995" "0.972" "0.993" "0.896" "0.968" "0.971" "0.963" "0.947" "0.694" "2888.9" "2875.5" "2806.7" "2868.4" "2589.8" "2795.2" "2806.0" "2781.8" "2734.7" "2004.2" "" "" "" "" "" "" "" "" "" "" "2561.8" "2381.9" "2449.0" "2145.2" "2159.6" "2567.7" "2371.6" "2299.4" "2508.1" "2004.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "74.945" "39" "18" "32" "5" "391" "42.3" "10.05" "105.83" "18" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "RND2 GTPase cycle; mRNA Splicing - Major Pathway; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "8" "11" "0.951" "0.878" "0.871" "0.837" "0.864" "0.825" "0.778" "0.930" "1.796" "2615.4" "2488.0" "2295.5" "2277.2" "2187.8" "2260.3" "2157.4" "2035.5" "2432.5" "4697.7" "" "" "" "" "" "" "" "" "" "" "2319.3" "2060.9" "2002.9" "1703.0" "1824.4" "2076.3" "1823.4" "1682.5" "2231.0" "4697.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "74.907" "31" "8" "22" "8" "298" "32.2" "7.39" "77.86" "8" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "0.998" "0.998" "1.035" "1.013" "1.014" "1.053" "1.047" "0.943" "0.496" "3293.8" "3287.0" "3287.5" "3408.4" "3336.7" "3341.5" "3467.6" "3447.5" "3105.7" "1634.2" "" "" "" "" "" "" "" "" "" "" "2920.8" "2722.8" "2868.5" "2549.1" "2782.4" "3069.5" "2930.7" "2849.6" "2848.4" "1634.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "74.899" "37" "13" "17" "13" "423" "48.6" "7.30" "63.89" "13" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "MHC class II antigen presentation; Neutrophil degranulation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "5" "0" "0.992" "0.944" "0.974" "0.928" "0.964" "0.956" "0.946" "0.933" "1.441" "1286.0" "1275.3" "1213.7" "1252.9" "1193.2" "1239.0" "1229.6" "1216.7" "1200.3" "1853.7" "" "" "" "" "" "" "" "" "" "" "1140.4" "1056.4" "1059.0" "937.0" "995.0" "1138.2" "1039.2" "1005.7" "1100.8" "1853.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "74.892" "47" "14" "33" "14" "358" "40.6" "5.94" "107.28" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "7" "0" "1.036" "1.005" "1.043" "1.066" "1.046" "1.081" "1.036" "0.961" "0.596" "3449.6" "3574.3" "3465.3" "3598.3" "3676.2" "3607.4" "3730.1" "3575.0" "3313.7" "2055.2" "" "" "" "" "" "" "" "" "" "" "3059.0" "2960.8" "3023.6" "2691.1" "3065.4" "3313.8" "3152.5" "2955.0" "3039.1" "2055.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "460406497697363824" "False" "High" "IsMasterProtein" "P61018" "Ras-related protein Rab-4B OS=Homo sapiens OX=9606 GN=RAB4B PE=1 SV=1" "0.000" "False" "74.844" "54" "10" "17" "7" "213" "23.6" "6.06" "66.46" "10" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53916" "ENSG00000167578" "RAB4B" "hsa:53916; P22750; P61018; Q7Z514; Q9HBR6" "Neutrophil degranulation; RAB geranylgeranylation; MET receptor recycling" "Intracellular trafficking proteins involved in CMT neuropathy" "4" "1" "1.075" "1.076" "1.118" "1.153" "1.122" "1.035" "1.073" "0.988" "0.551" "1115.1" "1198.9" "1199.4" "1246.9" "1286.1" "1251.6" "1153.7" "1197.0" "1101.6" "614.4" "" "" "" "" "" "" "" "" "" "" "988.9" "993.1" "1046.6" "932.6" "1072.5" "1149.7" "975.0" "989.4" "1010.4" "614.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5102173735616793815" "False" "High" "IsMasterProtein" "Q9BWH6" "RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3" "0.000" "False" "74.707" "14" "16" "20" "16" "1393" "152.7" "6.38" "68.48" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08620, Pf08621" "26015" "ENSG00000103932" "RPAP1" "hsa:26015; Q9BWH6; Q9H9I2; Q9NSQ5; Q9P2E4; Q9UFS7" "" "" "0" "0" "1.077" "0.972" "1.105" "1.094" "1.006" "1.097" "1.032" "0.975" "1.677" "1041.6" "1121.6" "1012.6" "1150.8" "1139.7" "1047.4" "1142.3" "1074.6" "1016.0" "1746.3" "" "" "" "" "" "" "" "" "" "" "923.7" "929.1" "883.5" "860.6" "950.4" "962.2" "965.5" "888.2" "931.8" "1746.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196663768808374141" "False" "High" "IsMasterProtein" "Q9UBP6" "tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1" "0.000" "False" "74.675" "34" "7" "23" "7" "276" "31.5" "7.64" "77.88" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02390" "4234" "ENSG00000037897" "METTL1" "B2RBX1; H7BXF2; hsa:4234; Q14105; Q53FS9; Q9UBP6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.018" "0.935" "1.021" "0.915" "0.996" "0.898" "0.947" "0.822" "0.488" "1103.7" "1123.6" "1032.4" "1126.4" "1010.3" "1099.1" "991.0" "1045.3" "907.2" "538.4" "" "" "" "" "" "" "" "" "" "" "978.8" "930.7" "900.8" "842.4" "842.4" "1009.6" "837.5" "864.1" "832.0" "538.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "74.624" "43" "12" "32" "12" "248" "27.4" "7.23" "114.75" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "Translation factors; 7q11.23 copy number variation syndrome" "7" "0" "0.968" "0.993" "0.986" "0.942" "1.004" "0.899" "0.980" "1.001" "0.842" "3344.8" "3236.4" "3322.8" "3296.4" "3150.4" "3358.5" "3005.9" "3277.2" "3347.2" "2815.1" "" "" "" "" "" "" "" "" "" "" "2966.1" "2680.9" "2899.3" "2465.2" "2627.0" "3085.1" "2540.4" "2708.9" "3069.8" "2815.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "74.603" "46" "11" "15" "11" "303" "33.8" "6.74" "66.13" "11" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Downstream signal transduction; Regulation of signaling by CBL; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "22" "0" "1.022" "1.048" "1.028" "0.993" "0.972" "0.966" "0.844" "0.908" "2.895" "1323.1" "1352.0" "1386.2" "1360.3" "1314.3" "1286.6" "1278.6" "1116.1" "1201.1" "3830.8" "" "" "" "" "" "" "" "" "" "" "1173.3" "1120.0" "1209.6" "1017.3" "1095.9" "1181.9" "1080.6" "922.5" "1101.6" "3830.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "74.503" "21" "9" "19" "7" "514" "55.4" "6.90" "69.76" "9" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "Potential therapeutics for SARS; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "" "4" "0" "1.026" "0.960" "1.125" "1.038" "1.039" "1.115" "1.119" "1.039" "0.621" "1106.9" "1135.5" "1062.5" "1245.6" "1149.1" "1150.5" "1234.3" "1238.7" "1149.8" "687.1" "" "" "" "" "" "" "" "" "" "" "981.6" "940.6" "927.1" "931.5" "958.2" "1056.9" "1043.2" "1023.9" "1054.6" "687.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "74.327" "41" "9" "25" "7" "200" "23.0" "8.37" "77.90" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "0.904" "0.958" "0.889" "0.912" "0.988" "0.931" "0.981" "0.935" "0.476" "2260.2" "2042.2" "2165.3" "2010.0" "2061.4" "2233.7" "2104.6" "2217.4" "2113.7" "1076.1" "" "" "" "" "" "" "" "" "" "" "2004.3" "1691.7" "1889.3" "1503.2" "1718.9" "2051.9" "1778.7" "1832.8" "1938.5" "1076.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "74.306" "52" "14" "20" "14" "264" "29.9" "9.73" "69.90" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.995" "0.982" "1.029" "0.967" "0.727" "0.868" "0.894" "0.990" "1.816" "2101.7" "2091.8" "2064.7" "2163.7" "2033.0" "1528.7" "1823.5" "1879.3" "2081.3" "3816.5" "" "" "" "" "" "" "" "" "" "" "1863.8" "1732.7" "1801.6" "1618.1" "1695.3" "1404.3" "1541.2" "1553.4" "1908.8" "3816.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "74.273" "47" "15" "23" "14" "351" "38.4" "7.02" "86.24" "15" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Synthesis of PA" "Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "1" "0.994" "1.031" "1.031" "0.995" "0.986" "0.941" "0.933" "0.916" "0.582" "2234.1" "2221.2" "2304.0" "2303.2" "2222.8" "2203.6" "2102.0" "2084.3" "2047.4" "1299.6" "" "" "" "" "" "" "" "" "" "" "1981.2" "1839.9" "2010.4" "1722.5" "1853.5" "2024.2" "1776.5" "1722.8" "1877.7" "1299.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "74.222" "39" "14" "22" "13" "340" "38.0" "8.63" "78.19" "14" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "Nuclear receptors meta-pathway; NRF2 pathway" "7" "0" "0.965" "0.893" "0.930" "0.859" "0.825" "0.978" "0.791" "1.005" "4.299" "2040.9" "1968.6" "1821.6" "1898.2" "1752.8" "1682.8" "1995.2" "1613.6" "2051.3" "8774.3" "" "" "" "" "" "" "" "" "" "" "1809.9" "1630.7" "1589.5" "1419.6" "1461.6" "1545.8" "1686.3" "1333.7" "1881.3" "8774.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "74.192" "12" "15" "16" "14" "1447" "164.6" "8.47" "57.49" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "1" "0.913" "0.884" "0.947" "0.903" "0.929" "0.868" "0.507" "0.901" "7.744" "713.3" "651.4" "630.8" "675.7" "644.1" "662.6" "619.0" "361.8" "643.0" "5523.3" "" "" "" "" "" "" "" "" "" "" "632.5" "539.6" "550.4" "505.3" "537.1" "608.7" "523.2" "299.1" "589.7" "5523.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4946696058487786946" "False" "High" "IsMasterProtein" "Q9UHJ6" "Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=4" "0.000" "False" "74.102" "24" "8" "15" "8" "478" "51.5" "6.83" "52.91" "8" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00370" "23729" "ENSG00000197417" "SHPK" "B2R640; Q8WUH3; Q9UHJ6" "Pentose phosphate pathway" "" "1" "0" "1.100" "1.084" "1.103" "1.192" "1.067" "1.185" "1.120" "0.952" "1.191" "985.8" "1083.9" "1068.4" "1087.1" "1175.4" "1051.8" "1168.1" "1104.2" "938.5" "1174.1" "" "" "" "" "" "" "" "" "" "" "874.2" "897.8" "932.2" "813.0" "980.2" "966.2" "987.2" "912.7" "860.7" "1174.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "74.070" "24" "14" "16" "14" "689" "79.5" "7.28" "59.70" "14" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "G alpha (s) signalling events; G alpha (q) signalling events; Activation of SMO; Cargo recognition for clathrin-mediated endocytosis; Calmodulin induced events" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "9" "0" "1.061" "0.959" "1.117" "1.049" "1.000" "1.228" "1.038" "0.981" "1.194" "1356.7" "1440.0" "1300.6" "1515.3" "1422.9" "1356.2" "1666.5" "1408.8" "1331.4" "1620.3" "" "" "" "" "" "" "" "" "" "" "1203.1" "1192.9" "1134.8" "1133.2" "1186.5" "1245.8" "1408.4" "1164.4" "1221.1" "1620.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "74.062" "60" "9" "10" "9" "202" "21.2" "5.15" "49.32" "9" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.026" "0.932" "0.926" "0.929" "0.896" "0.973" "0.938" "0.916" "0.737" "970.5" "995.5" "905.0" "899.1" "901.7" "869.8" "944.7" "910.5" "888.8" "715.4" "" "" "" "" "" "" "" "" "" "" "860.6" "824.6" "789.6" "672.4" "751.9" "799.0" "798.4" "752.6" "815.1" "715.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "132073470049357313" "False" "High" "IsMasterProtein" "Q58FF6" "Putative heat shock protein HSP 90-beta 4 OS=Homo sapiens OX=9606 GN=HSP90AB4P PE=5 SV=1" "0.000" "False" "74.020" "10" "8" "90" "1" "505" "58.2" "4.73" "246.27" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00183" "" "" "HSP90AB4P" "Q58FF6" "" "" "0" "0" "1.108" "1.244" "1.373" "1.594" "1.451" "1.356" "1.373" "0.980" "1.841" "144.0" "159.6" "179.1" "197.8" "229.6" "208.9" "195.4" "197.8" "141.2" "265.2" "" "" "" "" "" "" "" "" "" "" "127.7" "132.2" "156.3" "147.9" "191.5" "191.9" "165.1" "163.5" "129.5" "265.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "High" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.000" "False" "74.011" "15" "11" "13" "11" "979" "104.7" "6.29" "57.54" "11" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "" "Alstrom syndrome" "1" "0" "1.060" "1.080" "1.062" "1.085" "1.078" "1.080" "1.022" "1.077" "0.850" "733.1" "777.1" "792.0" "778.6" "795.1" "790.5" "791.8" "749.1" "789.7" "622.8" "" "" "" "" "" "" "" "" "" "" "650.1" "643.7" "691.0" "582.3" "663.0" "726.1" "669.2" "619.2" "724.3" "622.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "73.998" "41" "10" "16" "10" "297" "33.7" "7.14" "66.10" "10" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "ERBB2 Regulates Cell Motility" "" "1" "0" "1.010" "1.036" "0.979" "0.972" "0.988" "1.050" "1.082" "1.090" "0.813" "1241.3" "1253.6" "1286.4" "1214.7" "1207.0" "1226.1" "1304.0" "1343.2" "1352.8" "1009.8" "" "" "" "" "" "" "" "" "" "" "1100.8" "1038.4" "1122.5" "908.5" "1006.5" "1126.3" "1102.1" "1110.2" "1240.7" "1009.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "73.977" "35" "12" "21" "12" "379" "44.4" "5.08" "77.21" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "9" "0" "1.056" "1.001" "1.005" "1.099" "1.100" "1.145" "1.147" "1.112" "0.637" "1620.8" "1712.3" "1623.1" "1628.8" "1781.9" "1782.8" "1856.4" "1859.9" "1801.8" "1032.9" "" "" "" "" "" "" "" "" "" "" "1437.3" "1418.4" "1416.2" "1218.1" "1485.8" "1637.7" "1568.9" "1537.3" "1652.5" "1032.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869717489525171844" "False" "High" "IsMasterProtein" "O60306" "RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4" "0.000" "False" "73.965" "9" "13" "16" "13" "1485" "171.2" "6.37" "60.61" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf16399, Pf21143, Pf21144" "9716" "ENSG00000021776" "AQR" "A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "5" "0" "1.023" "0.985" "1.037" "1.036" "1.091" "1.025" "0.958" "0.963" "1.989" "1464.5" "1497.5" "1443.1" "1519.3" "1517.1" "1598.1" "1501.3" "1402.5" "1410.5" "2913.5" "" "" "" "" "" "" "" "" "" "" "1298.7" "1240.5" "1259.2" "1136.2" "1265.1" "1468.1" "1268.9" "1159.3" "1293.6" "2913.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5775967720321499285" "False" "High" "IsMasterProtein" "Q99879" "Histone H2B type 1-M OS=Homo sapiens OX=9606 GN=H2BC14 PE=1 SV=3" "0.000" "False" "73.963" "65" "11" "46" "3" "126" "14.0" "10.32" "154.11" "11" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8342" "ENSG00000273703" "H2BC14" "hsa:8342; Q6NWQ3; Q99879" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Deposition of new CENPA-containing nucleosomes at the centromere; Ub-specific processing proteases; HATs acetylate histones; E3 ubiquitin ligases ubiquitinate target proteins; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "" "45" "9" "0.614" "0.585" "0.565" "0.605" "0.531" "0.519" "0.548" "0.554" "0.394" "8500.6" "5220.0" "4972.3" "4804.1" "5142.0" "4517.3" "4410.5" "4656.5" "4710.7" "3349.0" "" "" "" "" "" "" "" "" "" "" "7538.1" "4324.0" "4338.6" "3592.8" "4287.7" "4149.6" "3727.6" "3848.9" "4320.4" "3349.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "73.940" "25" "13" "34" "13" "501" "55.8" "7.53" "100.85" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "37" "0" "1.010" "0.983" "1.015" "1.007" "1.000" "0.922" "0.926" "0.947" "0.626" "2129.2" "2150.8" "2092.8" "2161.3" "2144.1" "2129.5" "1962.5" "1972.5" "2016.6" "1333.0" "" "" "" "" "" "" "" "" "" "" "1888.1" "1781.6" "1826.0" "1616.4" "1787.9" "1956.2" "1658.7" "1630.4" "1849.5" "1333.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "73.918" "26" "10" "41" "7" "363" "39.6" "4.58" "128.42" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "6" "0" "1.022" "0.984" "1.003" "0.973" "0.973" "1.027" "1.005" "0.988" "0.592" "2444.5" "2498.4" "2405.8" "2450.8" "2378.4" "2379.4" "2509.3" "2455.7" "2414.1" "1446.4" "" "" "" "" "" "" "" "" "" "" "2167.8" "2069.6" "2099.2" "1832.9" "1983.3" "2185.7" "2120.8" "2029.8" "2214.1" "1446.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "73.832" "59" "8" "30" "6" "151" "16.9" "4.65" "115.77" "8" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Ciliary landscape" "8" "3" "0.967" "0.975" "1.000" "1.003" "1.025" "1.032" "1.057" "1.108" "0.915" "3299.0" "3188.9" "3215.3" "3299.7" "3308.9" "3381.8" "3405.6" "3487.1" "3654.6" "3018.0" "" "" "" "" "" "" "" "" "" "" "2925.5" "2641.5" "2805.5" "2467.7" "2759.2" "3106.5" "2878.3" "2882.4" "3351.8" "3018.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "High" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.000" "False" "73.759" "24" "11" "17" "11" "559" "61.6" "6.46" "66.24" "11" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "8" "0" "1.034" "0.958" "1.053" "1.008" "0.997" "1.021" "1.032" "0.920" "0.619" "1615.5" "1670.7" "1547.5" "1701.4" "1629.1" "1611.3" "1649.5" "1667.6" "1486.2" "999.7" "" "" "" "" "" "" "" "" "" "" "1432.6" "1383.9" "1350.3" "1272.4" "1358.4" "1480.2" "1394.1" "1378.4" "1363.0" "999.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "73.714" "34" "5" "13" "5" "184" "20.7" "7.99" "58.61" "5" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.070" "1.073" "1.029" "1.046" "1.109" "1.124" "1.118" "1.037" "0.573" "1029.5" "1101.8" "1104.8" "1059.5" "1077.1" "1141.9" "1157.3" "1150.9" "1067.2" "589.7" "" "" "" "" "" "" "" "" "" "" "912.9" "912.7" "964.0" "792.3" "898.1" "1048.9" "978.1" "951.3" "978.7" "589.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-930823423680918184" "False" "High" "IsMasterProtein" "Q53H82" "Endoribonuclease LACTB2 OS=Homo sapiens OX=9606 GN=LACTB2 PE=1 SV=2" "0.000" "False" "73.561" "35" "9" "17" "9" "288" "32.8" "6.80" "65.29" "9" "" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00753, Pf17778" "51110" "ENSG00000147592" "LACTB2" "A8K2D6; hsa:51110; Q53H82; Q9Y392" "" "" "0" "0" "1.029" "0.987" "0.990" "1.006" "1.077" "0.978" "1.000" "1.057" "0.506" "1317.7" "1355.3" "1300.4" "1304.2" "1326.1" "1419.1" "1288.4" "1317.2" "1393.0" "667.4" "" "" "" "" "" "" "" "" "" "" "1168.5" "1122.7" "1134.7" "975.4" "1105.8" "1303.6" "1088.9" "1088.7" "1277.6" "667.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "High" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.000" "False" "73.550" "52" "13" "16" "13" "320" "36.2" "6.16" "61.48" "13" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "0.980" "0.994" "0.962" "1.002" "1.035" "1.019" "1.016" "1.031" "1.576" "897.4" "879.5" "892.1" "863.4" "898.8" "928.9" "914.4" "911.6" "925.6" "1414.4" "" "" "" "" "" "" "" "" "" "" "795.8" "728.6" "778.4" "645.7" "749.5" "853.3" "772.8" "753.5" "848.9" "1414.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "73.529" "35" "10" "21" "10" "305" "35.1" "5.69" "80.19" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "0.983" "0.994" "0.959" "0.969" "0.966" "0.896" "0.945" "0.871" "0.793" "2079.7" "2043.9" "2066.6" "1995.1" "2014.2" "2008.2" "1864.2" "1965.1" "1811.9" "1649.0" "" "" "" "" "" "" "" "" "" "" "1844.2" "1693.1" "1803.2" "1492.1" "1679.6" "1844.7" "1575.5" "1624.3" "1661.8" "1649.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574193745658390357" "False" "High" "IsMasterProtein" "P46926" "Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens OX=9606 GN=GNPDA1 PE=1 SV=1" "0.000" "False" "73.469" "48" "10" "15" "7" "289" "32.6" "6.92" "63.48" "10" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01182" "10007" "ENSG00000113552" "GNPDA1" "B7Z3X4; D3DQE7; hsa:10007; P46926" "Glycolysis" "" "1" "4" "1.079" "1.072" "1.071" "1.113" "1.098" "1.046" "1.104" "0.992" "0.700" "1168.4" "1260.4" "1252.3" "1251.4" "1300.7" "1283.2" "1221.6" "1290.2" "1159.2" "817.9" "" "" "" "" "" "" "" "" "" "" "1036.1" "1044.0" "1092.7" "935.9" "1084.6" "1178.7" "1032.4" "1066.5" "1063.2" "817.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "73.360" "35" "6" "16" "5" "185" "21.4" "4.93" "69.82" "6" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "HCMV Early Events" "Effect of progerin on genes involved in progeria" "2" "0" "0.923" "0.908" "1.017" "0.914" "0.983" "0.843" "0.877" "0.876" "0.486" "1452.5" "1341.1" "1319.6" "1476.4" "1327.9" "1427.6" "1224.3" "1273.9" "1271.9" "705.7" "" "" "" "" "" "" "" "" "" "" "1288.0" "1110.9" "1151.4" "1104.2" "1107.3" "1311.4" "1034.7" "1053.0" "1166.5" "705.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "73.336" "30" "13" "23" "12" "412" "45.7" "6.48" "80.62" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "" "1" "0" "0.930" "0.956" "0.946" "0.962" "0.970" "0.969" "0.884" "0.991" "2.451" "2442.0" "2271.2" "2334.3" "2309.2" "2349.7" "2367.8" "2367.2" "2158.6" "2420.6" "5986.4" "" "" "" "" "" "" "" "" "" "" "2165.5" "1881.4" "2036.8" "1727.0" "1959.3" "2175.1" "2000.6" "1784.2" "2220.0" "5986.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "73.309" "59" "8" "47" "8" "148" "17.2" "9.60" "151.71" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "Mitochondrial protein degradation; Transcriptional activation of mitochondrial biogenesis" "" "2" "0" "1.019" "1.031" "0.995" "1.047" "1.105" "1.024" "1.072" "1.026" "0.404" "5968.6" "6084.2" "6153.0" "5939.6" "6251.1" "6596.1" "6109.9" "6397.6" "6123.4" "2411.2" "" "" "" "" "" "" "" "" "" "" "5292.8" "5039.8" "5368.8" "4442.1" "5212.5" "6059.2" "5163.8" "5288.1" "5616.0" "2411.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "73.222" "49" "8" "17" "8" "166" "19.2" "7.34" "76.24" "8" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "mRNA Splicing - Major Pathway" "" "1" "0" "0.963" "0.966" "0.933" "0.916" "0.929" "0.809" "0.884" "0.933" "0.381" "2939.0" "2831.1" "2838.2" "2741.1" "2690.8" "2729.2" "2378.9" "2597.5" "2743.1" "1119.2" "" "" "" "" "" "" "" "" "" "" "2606.3" "2345.1" "2476.5" "2050.0" "2243.8" "2507.1" "2010.5" "2147.0" "2515.8" "1119.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "73.084" "17" "15" "17" "15" "1000" "111.0" "5.54" "59.57" "15" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "COPII-mediated vesicle transport" "" "1" "0" "1.099" "1.033" "1.082" "1.114" "1.004" "1.080" "0.800" "1.016" "6.322" "502.8" "552.4" "519.3" "544.1" "560.2" "505.0" "543.1" "402.4" "511.0" "3178.8" "" "" "" "" "" "" "" "" "" "" "445.9" "457.6" "453.1" "406.9" "467.1" "463.9" "459.0" "332.6" "468.7" "3178.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "High" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.000" "False" "73.075" "28" "9" "19" "9" "386" "43.3" "6.01" "81.21" "9" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "1.045" "1.086" "1.023" "1.051" "1.052" "0.972" "1.005" "1.083" "1.396" "2263.3" "2364.1" "2456.8" "2315.7" "2379.8" "2381.1" "2200.4" "2274.1" "2451.0" "3158.6" "" "" "" "" "" "" "" "" "" "" "2007.0" "1958.3" "2143.7" "1731.8" "1984.5" "2187.3" "1859.7" "1879.7" "2247.9" "3158.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "73.023" "20" "11" "27" "6" "585" "63.8" "9.04" "88.85" "11" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "2" "0.991" "1.014" "0.966" "1.003" "0.991" "0.994" "1.039" "1.044" "0.672" "1677.7" "1662.8" "1701.6" "1621.2" "1683.1" "1662.0" "1668.3" "1742.5" "1751.8" "1127.8" "" "" "" "" "" "" "" "" "" "" "1487.8" "1377.4" "1484.8" "1212.5" "1403.5" "1526.8" "1409.9" "1440.3" "1606.7" "1127.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "73.017" "22" "13" "20" "13" "709" "79.6" "5.41" "77.49" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Caspase activation via Dependence Receptors in the absence of ligand" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "3" "0" "1.093" "1.022" "0.998" "0.976" "1.017" "0.964" "0.932" "1.020" "2.373" "992.3" "1084.5" "1014.0" "990.1" "968.5" "1008.9" "956.2" "924.7" "1011.8" "2354.5" "" "" "" "" "" "" "" "" "" "" "879.9" "898.3" "884.7" "740.4" "807.6" "926.8" "808.2" "764.4" "928.0" "2354.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.000" "False" "72.892" "24" "10" "16" "10" "496" "53.3" "7.77" "65.91" "10" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "Neutrophil degranulation" "5q35 copy number variation" "2" "0" "1.092" "1.004" "1.112" "1.101" "0.983" "1.025" "0.992" "0.945" "1.432" "1453.9" "1587.1" "1459.2" "1616.4" "1601.3" "1429.1" "1490.2" "1442.1" "1374.3" "2081.8" "" "" "" "" "" "" "" "" "" "" "1289.3" "1314.7" "1273.2" "1208.8" "1335.3" "1312.8" "1259.5" "1192.0" "1260.4" "2081.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "72.849" "30" "10" "19" "10" "377" "41.9" "9.16" "71.29" "10" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "4" "0" "1.018" "0.995" "0.981" "1.074" "1.084" "1.011" "1.085" "0.984" "0.371" "2079.1" "2116.9" "2068.8" "2039.3" "2233.3" "2253.5" "2101.3" "2256.8" "2045.2" "771.9" "" "" "" "" "" "" "" "" "" "" "1843.7" "1753.6" "1805.1" "1525.1" "1862.3" "2070.1" "1775.9" "1865.4" "1875.7" "771.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "72.805" "37" "8" "16" "8" "253" "28.1" "9.54" "60.15" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation" "" "2" "0" "1.005" "1.020" "0.993" "1.019" "0.997" "0.968" "1.020" "0.963" "0.551" "2366.6" "2378.7" "2413.4" "2350.1" "2411.1" "2359.6" "2291.7" "2415.0" "2278.4" "1304.5" "" "" "" "" "" "" "" "" "" "" "2098.6" "1970.4" "2105.8" "1757.6" "2010.5" "2167.6" "1936.9" "1996.1" "2089.6" "1304.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "72.707" "49" "9" "15" "6" "218" "24.4" "6.07" "59.92" "9" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; TBC/RABGAPs; MET receptor recycling" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "9" "0" "1.056" "1.008" "1.020" "1.069" "1.058" "0.970" "0.997" "0.875" "0.588" "387.1" "408.8" "390.2" "394.8" "414.0" "409.6" "375.4" "386.1" "338.5" "227.7" "" "" "" "" "" "" "" "" "" "" "343.3" "338.7" "340.4" "295.3" "345.2" "376.2" "317.3" "319.1" "310.5" "227.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "72.516" "46" "9" "25" "9" "289" "31.4" "7.36" "118.44" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.078" "1.076" "1.133" "1.181" "1.051" "1.101" "1.095" "1.109" "0.651" "1816.9" "1958.3" "1955.5" "2058.5" "2145.0" "1909.2" "2001.0" "1990.4" "2014.7" "1182.5" "" "" "" "" "" "" "" "" "" "" "1611.2" "1622.1" "1706.3" "1539.5" "1788.6" "1753.8" "1691.2" "1645.2" "1847.7" "1182.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2640936912706823496" "False" "High" "IsMasterProtein" "O14490" "Disks large-associated protein 1 OS=Homo sapiens OX=9606 GN=DLGAP1 PE=1 SV=1" "0.000" "False" "72.512" "9" "8" "14" "8" "977" "108.8" "7.08" "57.69" "8" "cell-cell signaling" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "9229" "ENSG00000170579" "DLGAP1" "A8MWN8; B2RMU8; B7WPA1; B7Z2H2; B7Z2I2; B7Z9Y4; hsa:9229; O14489; O14490; P78335" "Neurexins and neuroligins" "Disruption of postsynaptic signaling by CNV" "2" "0" "1.065" "1.037" "1.020" "1.046" "1.010" "0.905" "0.854" "0.879" "1.123" "1725.6" "1838.2" "1789.2" "1760.0" "1805.5" "1743.3" "1561.1" "1474.2" "1517.1" "1938.0" "" "" "" "" "" "" "" "" "" "" "1530.2" "1522.7" "1561.2" "1316.3" "1505.6" "1601.5" "1319.4" "1218.6" "1391.4" "1938.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "72.510" "21" "7" "15" "7" "404" "43.4" "4.88" "65.99" "7" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "0.964" "0.926" "0.909" "0.879" "0.819" "0.758" "0.905" "0.891" "0.487" "2394.6" "2307.5" "2217.8" "2175.5" "2104.1" "1961.0" "1814.6" "2167.9" "2134.5" "1165.2" "" "" "" "" "" "" "" "" "" "" "2123.5" "1911.4" "1935.1" "1627.0" "1754.5" "1801.4" "1533.6" "1791.9" "1957.6" "1165.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "72.391" "38" "11" "22" "9" "298" "33.9" "8.68" "77.45" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "CDK-mediated phosphorylation and removal of Cdc6; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "47" "0" "1.064" "1.001" "1.137" "1.076" "1.024" "1.170" "1.209" "1.020" "0.785" "2020.5" "2149.4" "2022.0" "2298.0" "2174.2" "2069.1" "2364.2" "2443.6" "2061.5" "1585.6" "" "" "" "" "" "" "" "" "" "" "1791.7" "1780.5" "1764.3" "1718.6" "1813.0" "1900.7" "1998.1" "2019.8" "1890.6" "1585.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "72.381" "27" "11" "20" "6" "440" "47.5" "6.77" "75.72" "11" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "Deactivation of the beta-catenin transactivating complex; SUMOylation of transcription cofactors; Repression of WNT target genes; Signaling by TCF7L2 mutants" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "14" "3" "1.023" "1.017" "1.031" "1.055" "1.019" "1.055" "1.031" "0.951" "0.554" "1799.3" "1840.5" "1830.1" "1855.3" "1897.7" "1833.8" "1898.5" "1854.7" "1711.4" "996.4" "" "" "" "" "" "" "" "" "" "" "1595.6" "1524.6" "1596.9" "1387.5" "1582.4" "1684.5" "1604.5" "1533.0" "1569.6" "996.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "72.356" "51" "7" "19" "7" "142" "16.0" "4.31" "86.39" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "Mitochondrial protein import" "" "1" "0" "0.957" "1.020" "1.030" "1.037" "1.113" "1.007" "1.081" "1.029" "0.264" "3401.0" "3254.5" "3467.5" "3501.8" "3527.2" "3786.7" "3423.8" "3678.1" "3500.4" "896.8" "" "" "" "" "" "" "" "" "" "" "3015.9" "2695.9" "3025.6" "2618.9" "2941.2" "3478.5" "2893.6" "3040.2" "3210.3" "896.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "High" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.000" "False" "72.350" "18" "11" "14" "11" "718" "78.9" "8.27" "55.88" "11" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "" "3" "0" "1.103" "1.026" "1.151" "1.142" "1.035" "1.174" "1.115" "0.953" "0.747" "886.1" "977.3" "908.9" "1020.1" "1011.7" "917.2" "1040.6" "988.2" "844.1" "662.0" "" "" "" "" "" "" "" "" "" "" "785.8" "809.5" "793.0" "762.9" "843.6" "842.6" "879.5" "816.8" "774.2" "662.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "72.321" "29" "15" "25" "14" "474" "53.2" "7.08" "79.23" "15" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "0.989" "1.017" "0.985" "1.062" "1.031" "1.028" "1.035" "1.087" "0.623" "1986.7" "1965.1" "2021.4" "1957.6" "2110.0" "2047.8" "2041.5" "2057.0" "2159.5" "1237.0" "" "" "" "" "" "" "" "" "" "" "1761.8" "1627.8" "1763.8" "1464.0" "1759.5" "1881.1" "1725.4" "1700.3" "1980.5" "1237.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3244624518097785869" "False" "High" "IsMasterProtein" "Q676U5" "Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2" "0.000" "False" "72.310" "30" "15" "17" "15" "607" "68.2" "6.64" "63.55" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf08614" "55054" "ENSG00000085978; ENSG00000281089" "ATG16L1" "A3EXK9; A3EXL0; B6ZDH0; hsa:55054; Q676U5; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619" "Macroautophagy" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "8" "0" "0.952" "0.976" "1.039" "1.048" "1.072" "0.988" "1.024" "0.934" "0.572" "1845.8" "1758.1" "1802.3" "1917.6" "1933.6" "1978.8" "1823.2" "1890.6" "1724.5" "1056.6" "" "" "" "" "" "" "" "" "" "" "1636.8" "1456.3" "1572.6" "1434.1" "1612.4" "1817.8" "1540.9" "1562.7" "1581.6" "1056.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.000" "False" "72.273" "22" "6" "13" "6" "421" "44.9" "7.52" "56.72" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "22q11.2 copy number variation syndrome" "4" "0" "1.172" "1.133" "1.081" "0.997" "1.006" "1.014" "0.124" "0.956" "18.924" "235.3" "275.7" "266.5" "254.2" "234.5" "236.8" "238.5" "29.2" "224.8" "4452.2" "" "" "" "" "" "" "" "" "" "" "208.6" "228.4" "232.6" "190.1" "195.5" "217.5" "201.6" "24.1" "206.2" "4452.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "72.254" "25" "14" "17" "14" "650" "72.5" "8.05" "56.71" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "0.996" "0.995" "0.947" "0.920" "0.980" "0.798" "0.749" "0.768" "1.681" "1494.6" "1489.3" "1487.2" "1415.3" "1375.2" "1465.3" "1192.6" "1120.2" "1148.1" "2512.6" "" "" "" "" "" "" "" "" "" "" "1325.4" "1233.7" "1297.6" "1058.5" "1146.7" "1346.1" "1008.0" "925.9" "1052.9" "2512.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.000" "False" "72.246" "39" "9" "15" "9" "268" "29.3" "8.91" "59.26" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "" "2" "0" "1.008" "1.015" "1.065" "1.066" "1.007" "0.990" "1.076" "0.939" "0.469" "1276.6" "1286.4" "1295.4" "1359.5" "1360.7" "1285.7" "1263.2" "1373.7" "1199.0" "598.6" "" "" "" "" "" "" "" "" "" "" "1132.1" "1065.6" "1130.3" "1016.7" "1134.6" "1181.0" "1067.6" "1135.5" "1099.6" "598.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588161142439279914" "False" "High" "IsMasterProtein" "Q96RG2" "PAS domain-containing serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=PASK PE=1 SV=3" "0.000" "False" "72.242" "12" "11" "13" "11" "1323" "142.8" "4.86" "50.50" "11" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13426" "23178" "ENSG00000115687" "PASK" "G5E9F1; hsa:23178; Q05BE4; Q68DY3; Q6GSJ5; Q86XH6; Q96RG2; Q99763; Q9UFR7" "" "2q37 copy number variation syndrome" "1" "0" "1.123" "1.055" "1.105" "1.097" "1.075" "1.131" "1.064" "1.060" "1.193" "728.8" "818.4" "768.8" "805.1" "799.8" "783.4" "824.6" "775.3" "772.4" "869.2" "" "" "" "" "" "" "" "" "" "" "646.3" "677.9" "670.8" "602.1" "666.9" "719.7" "696.9" "640.8" "708.4" "869.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "72.228" "34" "10" "20" "10" "309" "34.4" "7.33" "64.24" "10" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "" "1" "0" "1.029" "0.987" "1.084" "1.068" "1.081" "1.055" "1.075" "1.027" "0.635" "1274.0" "1310.7" "1258.0" "1380.9" "1360.3" "1377.7" "1343.8" "1369.5" "1308.8" "809.1" "" "" "" "" "" "" "" "" "" "" "1129.8" "1085.7" "1097.7" "1032.7" "1134.3" "1265.6" "1135.7" "1132.0" "1200.4" "809.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "72.100" "12" "14" "17" "14" "1278" "141.6" "5.81" "51.69" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; XBP1(S) activates chaperone genes" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "8" "0" "1.144" "0.840" "0.926" "0.875" "0.877" "1.089" "0.622" "0.979" "5.090" "792.5" "906.7" "665.5" "734.0" "693.1" "695.3" "863.2" "492.7" "775.5" "4033.5" "" "" "" "" "" "" "" "" "" "" "702.8" "751.1" "580.7" "548.9" "577.9" "638.7" "729.5" "407.2" "711.2" "4033.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "72.090" "36" "11" "31" "11" "264" "29.4" "6.98" "102.46" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "1.015" "1.026" "1.028" "1.076" "1.040" "1.058" "1.090" "0.994" "0.538" "4733.1" "4806.0" "4857.8" "4864.0" "5091.2" "4924.3" "5007.0" "5158.2" "4706.6" "2548.4" "" "" "" "" "" "" "" "" "" "" "4197.2" "3981.1" "4238.7" "3637.6" "4245.3" "4523.5" "4231.7" "4263.6" "4316.6" "2548.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "72.023" "23" "11" "27" "11" "407" "42.1" "5.07" "99.85" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Ub-specific processing proteases; UCH proteinases" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "4" "0" "0.911" "0.946" "0.920" "0.900" "0.906" "1.053" "1.005" "1.090" "1.259" "3674.1" "3348.4" "3474.2" "3379.1" "3307.9" "3330.5" "3868.5" "3692.5" "4005.4" "4626.6" "" "" "" "" "" "" "" "" "" "" "3258.1" "2773.6" "3031.4" "2527.1" "2758.4" "3059.4" "3269.5" "3052.1" "3673.5" "4626.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.000" "False" "71.929" "54" "13" "24" "13" "239" "27.5" "8.29" "83.66" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "1.000" "1.022" "0.999" "1.084" "1.157" "0.723" "0.709" "0.735" "0.773" "2863.9" "2863.2" "2927.3" "2861.2" "3103.9" "3314.6" "2071.6" "2030.4" "2104.5" "2215.0" "" "" "" "" "" "" "" "" "" "" "2539.7" "2371.7" "2554.2" "2139.8" "2588.2" "3044.8" "1750.8" "1678.2" "1930.1" "2215.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "High" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.000" "False" "71.895" "24" "10" "11" "9" "527" "58.0" "6.43" "45.27" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "1" "0.975" "0.970" "1.009" "1.054" "0.968" "1.145" "0.664" "1.047" "8.189" "485.6" "473.5" "471.1" "490.2" "511.7" "469.9" "556.1" "322.2" "508.7" "3976.6" "" "" "" "" "" "" "" "" "" "" "430.6" "392.2" "411.0" "366.6" "426.7" "431.7" "470.0" "266.3" "466.5" "3976.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "71.877" "18" "14" "16" "14" "793" "91.0" "7.18" "58.79" "14" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "0.951" "0.974" "0.972" "0.995" "1.097" "1.050" "1.083" "1.005" "0.552" "1906.0" "1813.2" "1857.0" "1852.0" "1896.7" "2090.6" "2001.9" "2063.7" "1915.2" "1052.1" "" "" "" "" "" "" "" "" "" "" "1690.2" "1502.0" "1620.3" "1385.1" "1581.6" "1920.5" "1691.9" "1705.8" "1756.5" "1052.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "71.798" "26" "11" "15" "11" "465" "52.5" "7.39" "56.00" "11" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "1.062" "1.059" "1.147" "1.076" "1.020" "1.028" "1.059" "0.948" "0.643" "1490.5" "1583.5" "1578.4" "1709.0" "1604.2" "1520.2" "1532.7" "1578.6" "1412.7" "958.6" "" "" "" "" "" "" "" "" "" "" "1321.7" "1311.7" "1377.3" "1278.1" "1337.7" "1396.4" "1295.3" "1304.8" "1295.6" "958.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "71.752" "73" "6" "30" "6" "95" "10.8" "6.52" "123.57" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "1.017" "1.008" "1.074" "1.012" "1.035" "1.044" "1.078" "0.916" "0.434" "4491.5" "4568.2" "4527.5" "4824.1" "4544.6" "4648.9" "4689.9" "4842.4" "4115.5" "1951.2" "" "" "" "" "" "" "" "" "" "" "3983.0" "3784.1" "3950.5" "3607.8" "3789.6" "4270.5" "3963.7" "4002.6" "3774.4" "1951.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "71.676" "23" "9" "15" "8" "524" "56.5" "7.50" "62.30" "9" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "7" "0" "1.058" "0.997" "1.074" "1.149" "1.152" "1.182" "1.231" "1.202" "0.670" "792.4" "838.1" "790.4" "850.7" "910.5" "912.5" "936.3" "975.6" "952.6" "530.7" "" "" "" "" "" "" "" "" "" "" "702.7" "694.3" "689.7" "636.2" "759.2" "838.2" "791.3" "806.4" "873.6" "530.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "71.604" "36" "7" "26" "7" "218" "25.0" "4.93" "101.54" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "" "6" "0" "1.008" "0.971" "0.994" "0.943" "0.968" "0.951" "0.941" "0.941" "0.614" "2571.0" "2591.3" "2495.6" "2555.7" "2424.6" "2488.8" "2444.2" "2419.4" "2418.5" "1578.6" "" "" "" "" "" "" "" "" "" "" "2279.9" "2146.5" "2177.5" "1911.4" "2021.8" "2286.3" "2065.7" "1999.8" "2218.1" "1578.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "71.544" "18" "15" "18" "15" "824" "91.8" "7.02" "59.39" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle; 2q21.1 copy number variation syndrome" "20" "0" "0.942" "0.954" "0.958" "0.956" "0.919" "0.908" "0.857" "0.935" "1.474" "1706.7" "1607.5" "1627.9" "1634.5" "1631.2" "1567.8" "1549.6" "1462.9" "1595.2" "2514.8" "" "" "" "" "" "" "" "" "" "" "1513.4" "1331.6" "1420.4" "1222.4" "1360.2" "1440.2" "1309.7" "1209.2" "1463.0" "2514.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "71.497" "14" "11" "13" "8" "930" "103.5" "5.97" "53.72" "11" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "1" "0.985" "0.967" "0.894" "0.902" "0.968" "0.845" "0.846" "0.909" "1.294" "1653.0" "1628.2" "1598.6" "1477.5" "1491.5" "1599.5" "1397.4" "1397.8" "1501.9" "2138.8" "" "" "" "" "" "" "" "" "" "" "1465.8" "1348.7" "1394.9" "1105.0" "1243.7" "1469.4" "1181.0" "1155.4" "1377.4" "2138.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "71.467" "43" "11" "30" "11" "246" "28.1" "6.77" "108.65" "11" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "5" "0" "1.013" "1.004" "0.995" "0.982" "1.065" "0.825" "0.850" "0.825" "0.600" "4068.0" "4120.8" "4084.3" "4048.2" "3993.8" "4333.1" "3358.1" "3457.0" "3356.8" "2439.7" "" "" "" "" "" "" "" "" "" "" "3607.4" "3413.5" "3563.8" "3027.5" "3330.3" "3980.4" "2838.1" "2857.5" "3078.6" "2439.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "High" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.000" "False" "71.462" "29" "13" "15" "13" "505" "55.4" "4.88" "60.67" "13" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "0.979" "1.018" "0.894" "0.943" "0.925" "0.980" "0.864" "1.024" "1.705" "1766.4" "1729.0" "1798.2" "1579.3" "1665.4" "1633.7" "1730.9" "1525.4" "1808.9" "3011.6" "" "" "" "" "" "" "" "" "" "" "1566.4" "1432.3" "1569.0" "1181.1" "1388.7" "1500.7" "1462.9" "1260.8" "1659.0" "3011.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7223228418441482962" "False" "High" "IsMasterProtein" "Q15648" "Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4" "0.000" "False" "71.425" "11" "15" "17" "15" "1581" "168.4" "8.73" "65.86" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10744" "5469" "ENSG00000125686" "MED1" "A2RRQ6; hsa:5469; O43810; O75447; Q15648; Q6P9H7; Q6PK58; Q9HD39" "Estrogen-dependent gene expression; Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "Energy metabolism; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Non-genomic actions of 1,25 dihydroxyvitamin D3; 17q12 copy number variation syndrome" "18" "0" "0.913" "0.908" "0.838" "0.807" "0.816" "0.796" "0.817" "0.876" "1.052" "1221.9" "1115.5" "1109.0" "1024.5" "986.4" "997.3" "972.6" "998.2" "1070.9" "1285.8" "" "" "" "" "" "" "" "" "" "" "1083.6" "924.0" "967.7" "766.2" "822.5" "916.1" "822.0" "825.1" "982.2" "1285.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864595288643475005" "False" "High" "IsMasterProtein" "P61011" "Signal recognition particle subunit SRP54 OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "0.000" "False" "71.423" "26" "11" "13" "11" "504" "55.7" "8.75" "53.79" "11" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "SRP-dependent cotranslational protein targeting to membrane" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "0.983" "0.999" "1.022" "1.030" "0.983" "1.007" "0.918" "0.994" "1.520" "1748.5" "1718.7" "1745.9" "1787.4" "1801.8" "1719.4" "1759.9" "1605.0" "1738.7" "2657.2" "" "" "" "" "" "" "" "" "" "" "1550.5" "1423.7" "1523.4" "1336.7" "1502.5" "1579.5" "1487.4" "1326.6" "1594.6" "2657.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "71.319" "62" "8" "37" "8" "118" "13.5" "9.91" "128.26" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "1.000" "0.983" "1.007" "0.983" "0.967" "0.968" "1.008" "0.987" "0.613" "4690.8" "4688.7" "4613.2" "4724.3" "4612.8" "4535.1" "4538.5" "4727.7" "4630.0" "2876.9" "" "" "" "" "" "" "" "" "" "" "4159.7" "3883.9" "4025.3" "3533.2" "3846.4" "4166.0" "3835.7" "3907.8" "4246.4" "2876.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "71.184" "42" "14" "28" "14" "253" "29.8" "9.06" "88.87" "14" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.934" "0.973" "0.900" "0.885" "0.941" "0.874" "0.907" "0.916" "0.924" "4276.6" "3994.0" "4159.8" "3848.2" "3783.5" "4022.8" "3736.7" "3879.3" "3918.5" "3950.8" "" "" "" "" "" "" "" "" "" "" "3792.4" "3308.5" "3629.6" "2877.9" "3154.9" "3695.4" "3158.1" "3206.5" "3593.8" "3950.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "High" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.000" "False" "71.182" "12" "10" "19" "10" "1029" "118.2" "8.47" "63.12" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "mRNA Splicing - Major Pathway" "" "1" "0" "0.992" "0.996" "0.991" "1.031" "1.030" "1.054" "1.058" "1.006" "1.280" "1410.3" "1398.8" "1404.9" "1397.4" "1453.8" "1453.1" "1486.3" "1491.7" "1418.5" "1805.6" "" "" "" "" "" "" "" "" "" "" "1250.7" "1158.7" "1225.9" "1045.1" "1212.2" "1334.8" "1256.2" "1233.0" "1301.0" "1805.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "High" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.000" "False" "71.090" "55" "8" "13" "8" "172" "19.7" "5.00" "56.15" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "0.995" "0.923" "0.985" "0.951" "0.970" "1.034" "1.020" "1.031" "0.629" "1877.2" "1867.7" "1732.7" "1849.5" "1785.0" "1820.8" "1940.7" "1915.0" "1934.6" "1181.0" "" "" "" "" "" "" "" "" "" "" "1664.6" "1547.1" "1511.8" "1383.2" "1488.5" "1672.6" "1640.2" "1582.8" "1774.3" "1181.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7145479494712382587" "False" "High" "IsMasterProtein" "P80217" "Interferon-induced 35 kDa protein OS=Homo sapiens OX=9606 GN=IFI35 PE=1 SV=5" "0.000" "False" "71.069" "51" "12" "16" "12" "286" "31.5" "6.09" "65.58" "12" "stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "3430" "ENSG00000068079" "IFI35" "C9JGX1; hsa:3430; P80217; Q92984; Q99537; Q9BV98" "Interferon alpha/beta signaling" "Immune response to tuberculosis" "2" "0" "1.001" "0.971" "1.071" "0.978" "0.972" "1.044" "1.053" "1.052" "0.516" "796.1" "796.7" "773.1" "852.4" "778.5" "773.4" "831.0" "838.3" "837.3" "411.1" "" "" "" "" "" "" "" "" "" "" "705.9" "660.0" "674.6" "637.5" "649.2" "710.5" "702.3" "692.9" "767.9" "411.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "70.956" "32" "13" "14" "13" "476" "54.4" "8.25" "57.62" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "18" "0" "1.030" "1.037" "0.867" "0.831" "0.833" "0.769" "0.807" "0.727" "0.766" "2087.8" "2149.6" "2166.1" "1809.7" "1735.0" "1738.3" "1604.5" "1685.3" "1517.2" "1599.1" "" "" "" "" "" "" "" "" "" "" "1851.4" "1780.7" "1890.0" "1353.4" "1446.7" "1596.8" "1356.1" "1393.0" "1391.4" "1599.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.000" "False" "70.942" "17" "13" "15" "13" "1023" "112.6" "8.40" "61.65" "13" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "1.077" "1.036" "1.071" "1.046" "1.030" "0.996" "0.947" "1.051" "1.675" "1132.5" "1219.5" "1173.7" "1213.3" "1184.8" "1166.2" "1128.1" "1072.1" "1190.2" "1897.2" "" "" "" "" "" "" "" "" "" "" "1004.3" "1010.1" "1024.1" "907.4" "988.0" "1071.2" "953.4" "886.2" "1091.6" "1897.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7294352330531963904" "False" "High" "IsMasterProtein" "Q99439" "Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4" "0.000" "False" "70.898" "34" "10" "19" "10" "309" "33.7" "7.33" "70.31" "10" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00402" "1265" "ENSG00000064666" "CNN2" "A5D8U8; A6NFI4; D6W5X9; hsa:1265; Q92578; Q99439" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Myometrial relaxation and contraction pathways; Burn wound healing" "4" "0" "0.978" "1.008" "0.977" "0.977" "0.978" "0.962" "0.863" "0.951" "3.138" "1964.5" "1921.4" "1979.4" "1919.0" "1919.8" "1920.5" "1888.9" "1694.9" "1868.6" "6165.4" "" "" "" "" "" "" "" "" "" "" "1742.1" "1591.6" "1727.1" "1435.1" "1600.8" "1764.2" "1596.4" "1400.9" "1713.8" "6165.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "High" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.000" "False" "70.878" "60" "6" "15" "6" "124" "13.7" "8.28" "72.36" "6" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.982" "0.990" "0.823" "0.881" "1.012" "0.894" "1.049" "0.959" "0.293" "1326.1" "1301.9" "1312.2" "1091.7" "1168.5" "1342.3" "1185.7" "1391.7" "1271.2" "388.2" "" "" "" "" "" "" "" "" "" "" "1176.0" "1078.4" "1145.0" "816.5" "974.4" "1233.0" "1002.1" "1150.4" "1165.8" "388.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172225001989641453" "False" "High" "IsMasterProtein" "Q9UNW1" "Multiple inositol polyphosphate phosphatase 1 OS=Homo sapiens OX=9606 GN=MINPP1 PE=1 SV=1" "0.000" "False" "70.845" "25" "11" "14" "11" "487" "55.0" "7.81" "58.71" "11" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00328" "9562" "ENSG00000107789" "MINPP1" "F5H683; hsa:9562; O95172; O95286; Q59EJ2; Q9UGA3; Q9UNW1" "Synthesis of IPs in the ER lumen" "" "1" "0" "1.032" "0.990" "1.056" "1.030" "1.090" "1.077" "1.139" "1.053" "0.530" "2087.6" "2154.8" "2066.2" "2205.5" "2150.4" "2275.5" "2247.6" "2377.6" "2197.8" "1107.4" "" "" "" "" "" "" "" "" "" "" "1851.3" "1784.9" "1802.9" "1649.5" "1793.2" "2090.3" "1899.6" "1965.3" "2015.7" "1107.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "70.789" "25" "7" "29" "7" "240" "24.6" "11.19" "86.80" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "0.975" "1.016" "1.083" "1.014" "1.010" "1.092" "1.044" "0.975" "0.757" "2345.5" "2287.4" "2383.0" "2539.8" "2377.4" "2368.3" "2562.4" "2449.6" "2287.6" "1776.6" "" "" "" "" "" "" "" "" "" "" "2080.0" "1894.8" "2079.3" "1899.4" "1982.4" "2175.5" "2165.7" "2024.8" "2098.0" "1776.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "70.681" "23" "10" "15" "10" "546" "59.2" "4.36" "53.52" "10" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "" "VEGFA-VEGFR2 signaling; mRNA processing" "2" "0" "1.029" "1.094" "0.978" "1.030" "0.813" "0.924" "0.579" "0.762" "6.602" "1765.5" "1815.8" "1931.3" "1727.0" "1817.8" "1435.2" "1631.3" "1022.3" "1345.9" "11655.9" "" "" "" "" "" "" "" "" "" "" "1565.6" "1504.1" "1685.2" "1291.6" "1515.8" "1318.4" "1378.7" "845.0" "1234.4" "11655.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3537193466780696360" "False" "High" "IsMasterProtein" "P30047" "GTP cyclohydrolase 1 feedback regulatory protein OS=Homo sapiens OX=9606 GN=GCHFR PE=1 SV=3" "0.000" "False" "70.648" "58" "3" "19" "3" "84" "9.7" "6.54" "88.98" "3" "other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf06399" "2644" "ENSG00000137880" "GCHFR" "B2R4L6; B7ZLM8; hsa:2644; P30047; Q2M1Q2; Q99749" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "1" "0" "1.046" "1.095" "1.026" "1.078" "1.153" "1.074" "1.112" "1.116" "0.597" "1786.7" "1868.4" "1956.8" "1832.8" "1926.2" "2060.5" "1918.0" "1986.3" "1993.4" "1067.5" "" "" "" "" "" "" "" "" "" "" "1584.4" "1547.7" "1707.4" "1370.7" "1606.1" "1892.8" "1621.1" "1641.8" "1828.3" "1067.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "70.582" "25" "13" "23" "13" "437" "51.5" "9.94" "81.39" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.005" "0.985" "0.927" "0.999" "0.908" "1.028" "1.019" "1.110" "1.318" "2772.8" "2787.7" "2732.6" "2570.2" "2769.3" "2517.1" "2849.8" "2825.3" "3078.9" "3654.9" "" "" "" "" "" "" "" "" "" "" "2458.9" "2309.2" "2384.3" "1922.1" "2309.2" "2312.2" "2408.5" "2335.3" "2823.8" "3654.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "70.578" "71" "11" "53" "11" "142" "15.9" "5.67" "187.17" "11" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "Neutrophil degranulation" "" "1" "0" "0.982" "1.008" "0.975" "0.971" "0.990" "1.007" "0.999" "0.967" "0.696" "5732.7" "5628.7" "5777.4" "5589.8" "5565.0" "5675.7" "5773.6" "5725.3" "5544.7" "3989.0" "" "" "" "" "" "" "" "" "" "" "5083.6" "4662.5" "5041.1" "4180.5" "4640.4" "5213.8" "4879.6" "4732.4" "5085.2" "3989.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "741210737454912212" "False" "High" "IsMasterProtein" "Q7Z7A4" "PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1" "0.000" "False" "70.392" "19" "9" "17" "9" "578" "64.9" "9.35" "67.10" "9" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf02205" "54899" "ENSG00000168297" "PXK" "hsa:54899; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q7Z7A4; Q96CA3; Q96R07; Q9NXB8" "" "" "0" "0" "1.006" "0.997" "1.126" "1.003" "0.976" "1.041" "0.818" "0.898" "2.333" "387.8" "390.2" "386.8" "436.7" "389.0" "378.4" "403.8" "317.3" "348.2" "904.8" "" "" "" "" "" "" "" "" "" "" "343.9" "323.2" "337.5" "326.6" "324.4" "347.6" "341.3" "262.2" "319.3" "904.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "70.352" "40" "11" "21" "11" "327" "35.9" "7.74" "81.85" "11" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "1.096" "0.991" "1.043" "1.074" "1.085" "1.016" "0.989" "0.926" "0.545" "1807.1" "1980.0" "1791.5" "1885.0" "1941.1" "1959.9" "1836.7" "1788.1" "1672.5" "984.0" "" "" "" "" "" "" "" "" "" "" "1602.5" "1640.1" "1563.2" "1409.7" "1618.6" "1800.4" "1552.3" "1478.0" "1533.9" "984.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.000" "False" "70.104" "16" "16" "18" "16" "1094" "121.2" "6.04" "60.90" "16" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "" "2" "0" "1.021" "0.992" "1.025" "0.958" "0.909" "1.034" "0.917" "0.990" "2.807" "962.1" "982.4" "954.0" "986.5" "921.8" "874.4" "994.7" "882.3" "952.7" "2700.6" "" "" "" "" "" "" "" "" "" "" "853.2" "813.7" "832.4" "737.8" "768.6" "803.2" "840.7" "729.3" "873.7" "2700.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "69.760" "47" "10" "18" "10" "249" "27.4" "8.06" "59.03" "10" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.952" "0.927" "0.910" "0.920" "0.981" "0.907" "0.872" "0.959" "1.871" "1744.8" "1660.9" "1617.6" "1588.0" "1604.5" "1711.9" "1582.4" "1521.4" "1673.1" "3263.9" "" "" "" "" "" "" "" "" "" "" "1547.2" "1375.8" "1411.5" "1187.6" "1337.9" "1572.6" "1337.4" "1257.5" "1534.4" "3263.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8009088926221679389" "False" "High" "IsMasterProtein" "P40616" "ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1" "0.000" "False" "69.738" "41" "6" "14" "6" "181" "20.4" "5.72" "66.23" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00025" "400" "ENSG00000120805" "ARL1" "B4DWW1; hsa:400; P40616; P80417; Q53XB1" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.129" "1.058" "1.199" "1.219" "1.039" "1.392" "1.272" "1.229" "1.187" "1318.9" "1489.3" "1396.1" "1582.0" "1608.0" "1370.8" "1836.0" "1678.2" "1620.5" "1565.7" "" "" "" "" "" "" "" "" "" "" "1169.6" "1233.7" "1218.1" "1183.1" "1340.9" "1259.2" "1551.7" "1387.1" "1486.2" "1565.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "69.580" "18" "15" "19" "14" "898" "103.3" "5.80" "64.88" "15" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "1" "1.059" "1.016" "1.058" "1.119" "1.072" "1.102" "1.094" "0.982" "0.623" "1054.4" "1116.7" "1071.0" "1115.8" "1179.6" "1130.1" "1161.9" "1153.1" "1035.5" "656.8" "" "" "" "" "" "" "" "" "" "" "935.0" "925.0" "934.5" "834.5" "983.7" "1038.1" "982.0" "953.1" "949.7" "656.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "High" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.000" "False" "69.499" "29" "12" "14" "12" "514" "57.2" "9.17" "66.69" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "mRNA Splicing - Major Pathway" "" "1" "0" "0.996" "0.946" "0.925" "0.954" "1.019" "0.907" "0.950" "0.920" "0.820" "1485.0" "1478.9" "1405.2" "1373.5" "1417.2" "1513.8" "1346.4" "1411.3" "1366.6" "1217.4" "" "" "" "" "" "" "" "" "" "" "1316.9" "1225.0" "1226.1" "1027.2" "1181.8" "1390.6" "1137.9" "1166.6" "1253.4" "1217.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "69.408" "11" "17" "20" "11" "1647" "184.5" "7.88" "61.03" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "13" "1" "1.074" "1.075" "1.096" "0.993" "1.050" "1.050" "0.630" "1.070" "9.820" "474.9" "510.0" "510.5" "520.3" "471.7" "498.7" "498.7" "299.1" "508.3" "4663.3" "" "" "" "" "" "" "" "" "" "" "421.1" "422.5" "445.5" "389.1" "393.3" "458.1" "421.4" "247.2" "466.2" "4663.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "69.364" "19" "15" "20" "15" "838" "93.9" "6.39" "69.59" "15" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "RHOH GTPase cycle" "Gastric cancer network 2" "2" "0" "1.015" "1.007" "1.001" "1.095" "1.049" "1.116" "1.020" "1.028" "0.949" "1322.9" "1343.2" "1332.3" "1324.6" "1448.1" "1387.8" "1476.7" "1349.4" "1360.1" "1255.0" "" "" "" "" "" "" "" "" "" "" "1173.1" "1112.6" "1162.5" "990.6" "1207.6" "1274.8" "1248.1" "1115.4" "1247.4" "1255.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4422070484711978078" "False" "High" "IsMasterProtein" "O95684" "Centrosomal protein 43 OS=Homo sapiens OX=9606 GN=CEP43 PE=1 SV=1" "0.000" "False" "69.363" "25" "7" "11" "7" "399" "43.0" "4.81" "48.57" "7" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09398" "11116" "ENSG00000213066" "CEP43" "A8K1D1; B2R705; hsa:11116; O95684; Q49AI0; Q5R3F6; Q96EW1" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "11" "0" "1.013" "0.940" "0.944" "0.913" "0.861" "0.862" "0.914" "0.967" "1.305" "996.0" "1009.4" "935.8" "940.7" "909.0" "857.7" "858.2" "909.9" "963.4" "1299.7" "" "" "" "" "" "" "" "" "" "" "883.3" "836.2" "816.6" "703.5" "758.0" "787.9" "725.3" "752.1" "883.6" "1299.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.000" "False" "69.351" "20" "13" "16" "13" "771" "87.9" "7.87" "64.39" "13" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.050" "1.031" "1.048" "1.015" "0.927" "0.829" "0.847" "0.823" "0.584" "1573.6" "1652.6" "1621.6" "1649.3" "1596.8" "1458.8" "1304.3" "1332.9" "1295.5" "919.1" "" "" "" "" "" "" "" "" "" "" "1395.4" "1368.9" "1415.0" "1233.5" "1331.5" "1340.1" "1102.4" "1101.7" "1188.2" "919.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6346583217180848630" "False" "High" "IsMasterProtein" "P09601" "Heme oxygenase 1 OS=Homo sapiens OX=9606 GN=HMOX1 PE=1 SV=1" "0.000" "False" "69.350" "30" "7" "17" "7" "288" "32.8" "8.25" "69.61" "7" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01126" "3162" "ENSG00000100292" "HMOX1" "hsa:3162; P09601" "Heme signaling; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Cytoprotection by HMOX1; Interleukin-4 and Interleukin-13 signaling; Regulation of HMOX1 expression and activity; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Iron uptake and transport; Heme degradation" "Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Overview of nanoparticle effects; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Lung fibrosis; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; IL-10 anti-inflammatory signaling pathway ; IL-18 signaling pathway; CAMKK2 pathway; Opioid receptor pathways; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Urotensin-II-mediated signaling pathway" "25" "0" "1.018" "1.014" "1.074" "1.019" "1.012" "1.020" "0.990" "1.013" "0.599" "1271.9" "1295.0" "1289.7" "1366.1" "1295.4" "1287.5" "1297.3" "1258.6" "1288.6" "761.5" "" "" "" "" "" "" "" "" "" "" "1127.9" "1072.7" "1125.3" "1021.7" "1080.2" "1182.7" "1096.4" "1040.3" "1181.9" "761.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "315483607845859686" "False" "High" "IsMasterProtein" "Q9BRF8" "Serine/threonine-protein phosphatase CPPED1 OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3" "0.000" "False" "69.329" "32" "7" "11" "7" "314" "35.5" "6.20" "55.57" "7" "" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf00149" "55313" "ENSG00000103381" "CPPED1" "B4DQ68; hsa:55313; Q6MZY9; Q9BRF8; Q9H9M9; Q9NUT6" "Neutrophil degranulation" "" "1" "0" "0.995" "0.987" "1.023" "0.946" "1.017" "1.010" "0.985" "0.856" "0.521" "1687.1" "1678.3" "1665.4" "1725.5" "1596.7" "1715.0" "1703.2" "1662.5" "1444.6" "879.6" "" "" "" "" "" "" "" "" "" "" "1496.0" "1390.3" "1453.2" "1290.5" "1331.4" "1575.4" "1439.5" "1374.2" "1324.9" "879.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "69.307" "41" "13" "19" "12" "298" "33.0" "9.22" "65.99" "13" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria" "4" "0" "0.962" "0.954" "0.963" "1.022" "1.105" "0.950" "1.033" "0.949" "0.468" "2900.8" "2790.7" "2766.5" "2793.3" "2963.4" "3205.5" "2756.8" "2997.3" "2751.5" "1356.6" "" "" "" "" "" "" "" "" "" "" "2572.4" "2311.7" "2413.9" "2089.0" "2471.1" "2944.6" "2329.9" "2477.5" "2523.5" "1356.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720179589779934486" "False" "High" "IsMasterProtein" "O96007" "Molybdopterin synthase catalytic subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1" "0.000" "False" "69.283" "41" "6" "12" "6" "188" "20.9" "5.44" "56.71" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02391" "4338" "ENSG00000164172" "MOCS2" "hsa:4338; O96007; Q6IAI3" "Molybdenum cofactor biosynthesis" "Metabolic Epileptic Disorders" "2" "0" "1.090" "1.105" "1.027" "1.091" "1.051" "1.106" "1.120" "1.058" "0.575" "1758.5" "1916.3" "1942.3" "1806.3" "1919.2" "1847.7" "1945.5" "1968.8" "1860.1" "1011.6" "" "" "" "" "" "" "" "" "" "" "1559.4" "1587.4" "1694.8" "1350.9" "1600.4" "1697.3" "1644.3" "1627.3" "1706.0" "1011.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "69.267" "31" "9" "21" "9" "249" "28.7" "10.84" "78.42" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "49" "0" "0.979" "1.008" "0.989" "0.976" "0.807" "0.889" "0.937" "1.048" "1.736" "3971.4" "3888.8" "4001.5" "3928.4" "3876.7" "3204.6" "3531.6" "3722.7" "4160.3" "6893.9" "" "" "" "" "" "" "" "" "" "" "3521.8" "3221.3" "3491.5" "2937.9" "3232.6" "2943.8" "2984.7" "3077.0" "3815.6" "6893.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2146106311129589736" "False" "High" "IsMasterProtein" "P35244" "Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1" "0.000" "False" "69.250" "45" "4" "17" "4" "121" "13.6" "5.08" "67.81" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08661" "6119" "ENSG00000106399" "RPA3" "hsa:6119; P35244; Q549U6" "HSF1 activation; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "36" "0" "1.066" "1.020" "1.178" "1.160" "1.174" "1.506" "1.501" "1.435" "1.007" "1408.3" "1501.2" "1437.1" "1659.0" "1633.1" "1652.8" "2121.0" "2113.9" "2020.4" "1418.8" "" "" "" "" "" "" "" "" "" "" "1248.8" "1243.6" "1254.0" "1240.7" "1361.8" "1518.3" "1792.6" "1747.3" "1853.0" "1418.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "High" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.000" "False" "69.147" "21" "14" "20" "14" "710" "81.4" "8.05" "70.51" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "1.011" "0.975" "1.004" "0.980" "1.039" "0.905" "0.887" "0.899" "1.121" "1549.9" "1566.3" "1510.6" "1556.6" "1518.2" "1610.5" "1402.4" "1374.4" "1393.1" "1737.1" "" "" "" "" "" "" "" "" "" "" "1374.4" "1297.4" "1318.1" "1164.2" "1266.0" "1479.5" "1185.2" "1136.1" "1277.7" "1737.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541335516874274105" "False" "High" "IsMasterProtein" "Q14527" "Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2" "0.000" "False" "69.129" "16" "15" "16" "15" "1009" "113.9" "8.60" "61.49" "15" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf08797, Pf13923" "6596" "ENSG00000071794" "HLTF" "D3DNH3; Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9" "E3 ubiquitin ligases ubiquitinate target proteins" "Retinoblastoma gene in cancer" "2" "0" "0.890" "0.861" "0.882" "0.838" "0.841" "0.876" "0.834" "0.925" "2.560" "2019.3" "1796.8" "1739.6" "1780.0" "1692.0" "1698.5" "1769.3" "1684.4" "1867.3" "5168.7" "" "" "" "" "" "" "" "" "" "" "1790.7" "1488.4" "1517.9" "1331.2" "1410.9" "1560.3" "1495.4" "1392.3" "1712.5" "5168.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "69.091" "15" "16" "20" "16" "1150" "132.7" "5.76" "65.11" "16" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "mRNA Splicing - Major Pathway" "" "1" "0" "1.191" "0.719" "0.686" "0.702" "0.691" "0.929" "0.585" "0.736" "2.972" "2157.9" "2569.3" "1550.9" "1481.0" "1514.3" "1490.1" "2004.0" "1261.5" "1588.8" "6413.5" "" "" "" "" "" "" "" "" "" "" "1913.6" "2128.3" "1353.2" "1107.6" "1262.8" "1368.8" "1693.7" "1042.7" "1457.2" "6413.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "69.064" "12" "6" "44" "1" "446" "49.9" "6.05" "146.50" "6" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "32" "0" "0.972" "0.926" "1.133" "1.022" "0.965" "0.947" "0.935" "0.759" "0.746" "550.2" "534.9" "509.3" "623.5" "562.2" "531.0" "521.3" "514.5" "417.6" "410.2" "" "" "" "" "" "" "" "" "" "" "487.9" "443.1" "444.4" "466.3" "468.8" "487.7" "440.6" "425.3" "383.0" "410.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286201540320348411" "False" "High" "IsMasterProtein" "Q92990" "Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2" "0.000" "False" "69.043" "25" "15" "19" "15" "594" "68.2" "5.33" "68.01" "15" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf08568" "11146" "ENSG00000174842" "GLMN" "hsa:11146; Q5VVC3; Q92990; Q9BVE8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.004" "0.996" "1.061" "0.968" "0.911" "1.113" "1.046" "1.030" "2.049" "1965.0" "1973.3" "1957.7" "2084.4" "1901.2" "1790.3" "2186.3" "2055.5" "2024.6" "4026.4" "" "" "" "" "" "" "" "" "" "" "1742.5" "1634.6" "1708.2" "1558.9" "1585.4" "1644.6" "1847.8" "1699.0" "1856.8" "4026.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "68.996" "31" "6" "26" "6" "182" "20.7" "8.69" "114.51" "6" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Platelet degranulation" "Orexin receptor pathway" "2" "0" "0.942" "0.975" "0.929" "0.959" "1.030" "0.976" "0.989" "0.981" "0.421" "3674.4" "3460.5" "3581.9" "3412.7" "3522.1" "3784.6" "3587.2" "3633.4" "3603.6" "1545.4" "" "" "" "" "" "" "" "" "" "" "3258.4" "2866.5" "3125.4" "2552.3" "2936.9" "3476.5" "3031.7" "3003.3" "3305.0" "1545.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "68.952" "65" "9" "23" "9" "138" "15.6" "7.61" "77.95" "9" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "0.988" "0.964" "0.906" "0.925" "0.938" "0.890" "0.958" "1.045" "0.737" "2437.5" "2408.3" "2350.1" "2207.4" "2253.8" "2285.7" "2169.7" "2335.4" "2547.7" "1797.3" "" "" "" "" "" "" "" "" "" "" "2161.5" "1994.9" "2050.6" "1650.9" "1879.3" "2099.7" "1833.7" "1930.3" "2336.6" "1797.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "68.879" "18" "14" "21" "13" "706" "79.9" "6.68" "75.61" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "9" "1" "1.043" "0.985" "1.104" "1.056" "1.061" "1.231" "1.047" "1.144" "2.774" "1364.7" "1423.1" "1344.8" "1506.6" "1440.6" "1447.5" "1679.6" "1428.8" "1561.7" "3785.8" "" "" "" "" "" "" "" "" "" "" "1210.2" "1178.8" "1173.4" "1126.8" "1201.3" "1329.7" "1419.5" "1181.0" "1432.3" "3785.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "68.867" "59" "13" "33" "13" "148" "16.4" "9.95" "105.59" "13" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "0.861" "0.838" "0.836" "0.789" "0.702" "0.714" "0.769" "0.788" "0.468" "4724.9" "4070.3" "3959.9" "3951.7" "3728.4" "3317.5" "3376.0" "3632.0" "3725.4" "2211.9" "" "" "" "" "" "" "" "" "" "" "4190.0" "3371.7" "3455.2" "2955.3" "3109.0" "3047.5" "2853.2" "3002.1" "3416.7" "2211.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "68.797" "52" "12" "18" "12" "244" "28.1" "6.65" "73.16" "12" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "tRNA processing in the nucleus" "" "1" "0" "0.954" "1.027" "0.862" "0.952" "1.017" "0.985" "0.962" "0.954" "1.100" "1735.5" "1655.5" "1782.8" "1495.7" "1652.4" "1764.4" "1710.0" "1669.1" "1656.4" "1908.2" "" "" "" "" "" "" "" "" "" "" "1539.0" "1371.4" "1555.6" "1118.6" "1377.9" "1620.8" "1445.2" "1379.6" "1519.2" "1908.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "68.656" "25" "12" "15" "12" "607" "68.6" "5.80" "66.00" "12" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "0.972" "0.858" "0.886" "0.862" "0.839" "1.135" "0.959" "1.021" "2.353" "1663.1" "1616.2" "1427.0" "1473.7" "1434.4" "1395.5" "1887.5" "1595.0" "1698.2" "3913.5" "" "" "" "" "" "" "" "" "" "" "1474.8" "1338.8" "1245.1" "1102.2" "1196.1" "1281.9" "1595.2" "1318.4" "1557.4" "3913.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "68.653" "15" "9" "15" "9" "706" "79.2" "6.44" "54.57" "9" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "Nicotinate metabolism" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "3" "0" "1.072" "0.999" "1.159" "1.077" "1.046" "1.106" "1.020" "0.889" "0.563" "1230.9" "1319.2" "1229.4" "1426.3" "1325.1" "1287.5" "1361.9" "1255.0" "1094.7" "693.5" "" "" "" "" "" "" "" "" "" "" "1091.5" "1092.7" "1072.7" "1066.7" "1105.0" "1182.7" "1151.0" "1037.4" "1004.0" "693.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "68.594" "25" "11" "14" "11" "508" "57.5" "7.80" "56.37" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "Cytosolic tRNA aminoacylation" "" "1" "0" "1.022" "0.995" "0.980" "1.085" "1.043" "1.105" "0.802" "0.982" "5.649" "656.1" "670.5" "652.6" "643.1" "711.5" "684.0" "724.9" "526.2" "644.3" "3706.1" "" "" "" "" "" "" "" "" "" "" "581.8" "555.4" "569.4" "481.0" "593.3" "628.3" "612.6" "434.9" "590.9" "3706.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "68.573" "50" "8" "34" "8" "129" "14.6" "8.88" "108.63" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.965" "0.951" "0.919" "0.977" "0.949" "0.890" "0.940" "0.892" "0.495" "3092.4" "2984.4" "2941.2" "2841.3" "3022.1" "2934.9" "2751.7" "2906.8" "2758.4" "1532.2" "" "" "" "" "" "" "" "" "" "" "2742.2" "2472.2" "2566.4" "2124.9" "2520.0" "2696.1" "2325.6" "2402.7" "2529.8" "1532.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "68.564" "29" "8" "17" "8" "347" "38.3" "7.64" "77.39" "8" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "0.985" "0.911" "0.945" "0.983" "0.925" "0.945" "0.994" "1.016" "0.837" "2144.2" "2112.4" "1952.9" "2025.6" "2108.0" "1984.4" "2025.2" "2132.4" "2178.4" "1794.5" "" "" "" "" "" "" "" "" "" "" "1901.4" "1749.8" "1704.0" "1514.9" "1757.8" "1822.9" "1711.6" "1762.6" "1997.9" "1794.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6132827760965537069" "False" "High" "IsMasterProtein" "Q7Z3D6" "D-glutamate cyclase, mitochondrial OS=Homo sapiens OX=9606 GN=DGLUCY PE=1 SV=2" "0.000" "False" "68.384" "27" "13" "15" "13" "616" "66.4" "6.79" "61.94" "13" "other metabolic processes" "mitochondrion" "other molecular function" "Pf07286, Pf14336" "80017" "ENSG00000133943" "DGLUCY" "B3KUI7; hsa:80017; Q7Z3D6; Q86SW3; Q86SX8; Q86SX9; Q86T08; Q86TV5; Q96GW5; Q9H7G0; Q9H8Y9; Q9H9W6" "" "" "0" "0" "1.081" "1.005" "1.069" "1.057" "1.063" "1.044" "1.008" "0.983" "0.720" "1650.5" "1784.0" "1659.5" "1763.7" "1743.8" "1754.1" "1722.6" "1663.5" "1622.6" "1188.2" "" "" "" "" "" "" "" "" "" "" "1463.7" "1477.8" "1448.0" "1319.0" "1454.1" "1611.3" "1455.8" "1375.0" "1488.2" "1188.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "68.244" "31" "10" "13" "10" "451" "51.1" "6.14" "57.28" "10" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Alstrom syndrome" "8" "0" "1.061" "1.055" "1.085" "1.056" "1.054" "1.194" "0.984" "1.060" "1.969" "864.2" "916.8" "912.0" "937.7" "912.2" "910.7" "1032.1" "850.6" "916.1" "1701.5" "" "" "" "" "" "" "" "" "" "" "766.3" "759.5" "795.8" "701.2" "760.6" "836.6" "872.3" "703.1" "840.2" "1701.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "68.204" "54" "9" "55" "9" "108" "12.8" "5.29" "163.82" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "Post-chaperonin tubulin folding pathway" "VEGFA-VEGFR2 signaling" "2" "0" "0.979" "0.998" "0.976" "1.011" "0.963" "0.942" "1.005" "0.995" "0.473" "7136.9" "6989.5" "7124.0" "6967.1" "7213.8" "6871.2" "6721.8" "7175.0" "7098.2" "3379.2" "" "" "" "" "" "" "" "" "" "" "6328.9" "5789.7" "6216.1" "5210.5" "6015.4" "6312.0" "5681.0" "5930.7" "6510.0" "3379.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "68.129" "56" "7" "20" "7" "140" "14.9" "10.51" "76.86" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "15" "0" "1.017" "1.041" "1.050" "1.057" "1.047" "1.016" "0.933" "0.919" "1.517" "1312.3" "1334.6" "1366.7" "1378.4" "1387.7" "1374.1" "1332.7" "1224.3" "1206.3" "1990.3" "" "" "" "" "" "" "" "" "" "" "1163.8" "1105.5" "1192.5" "1030.9" "1157.2" "1262.2" "1126.4" "1012.0" "1106.4" "1990.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "68.129" "48" "7" "26" "7" "154" "16.8" "5.24" "109.87" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Hypusine synthesis from eIF5A-lysine" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "3" "0" "0.954" "1.002" "0.986" "0.938" "0.895" "0.958" "0.849" "0.924" "2.268" "2800.6" "2673.1" "2807.1" "2760.4" "2628.2" "2506.6" "2684.0" "2378.6" "2588.5" "6352.3" "" "" "" "" "" "" "" "" "" "" "2483.5" "2214.2" "2449.3" "2064.4" "2191.6" "2302.6" "2268.4" "1966.1" "2374.0" "6352.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "68.081" "29" "9" "20" "9" "350" "37.9" "8.73" "80.70" "9" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "4" "0" "0.993" "0.968" "1.035" "1.023" "1.034" "1.036" "1.000" "0.924" "0.601" "2355.0" "2338.2" "2279.1" "2437.9" "2408.1" "2434.2" "2440.4" "2355.9" "2175.9" "1416.0" "" "" "" "" "" "" "" "" "" "" "2088.4" "1936.8" "1988.6" "1823.2" "2008.1" "2236.1" "2062.5" "1947.3" "1995.6" "1416.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6043879365308815932" "False" "High" "IsMasterProtein" "O75818" "Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3" "0.000" "False" "68.040" "26" "8" "13" "8" "363" "41.8" "6.67" "52.15" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08584" "10799" "ENSG00000124787" "RPP40" "hsa:10799; O75818; Q5VX97; Q8WVK8" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "0.994" "1.055" "0.969" "1.031" "1.036" "0.971" "1.027" "1.038" "0.479" "1448.8" "1439.6" "1527.9" "1403.3" "1493.2" "1501.4" "1406.3" "1488.6" "1503.4" "694.4" "" "" "" "" "" "" "" "" "" "" "1284.8" "1192.5" "1333.2" "1049.5" "1245.1" "1379.2" "1188.5" "1230.5" "1378.8" "694.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "68.038" "60" "9" "44" "1" "126" "13.9" "10.32" "145.33" "9" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Replacement of protamines by nucleosomes in the male pronucleus" "" "44" "0" "1.255" "1.294" "0.849" "1.315" "1.342" "0.985" "1.038" "1.308" "1.102" "211.1" "265.1" "273.2" "179.4" "277.6" "283.3" "207.9" "219.1" "276.1" "232.7" "" "" "" "" "" "" "" "" "" "" "187.2" "219.6" "238.4" "134.1" "231.4" "260.3" "175.7" "181.1" "253.3" "232.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "67.959" "45" "7" "16" "7" "174" "19.9" "5.72" "74.49" "7" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "6" "0" "0.894" "0.913" "0.835" "0.841" "0.891" "0.802" "0.858" "0.842" "0.685" "2221.8" "1986.5" "2029.3" "1854.3" "1868.2" "1978.8" "1782.3" "1906.4" "1870.9" "1522.7" "" "" "" "" "" "" "" "" "" "" "1970.3" "1645.5" "1770.7" "1386.8" "1557.8" "1817.7" "1506.3" "1575.8" "1715.8" "1522.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "67.871" "12" "12" "15" "12" "1053" "117.6" "5.86" "57.59" "12" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "" "Vitamin D receptor pathway" "1" "0" "1.021" "1.000" "1.041" "1.022" "0.973" "0.986" "0.922" "0.920" "0.688" "1807.2" "1845.5" "1807.1" "1880.6" "1847.1" "1758.6" "1781.0" "1667.1" "1663.3" "1243.3" "" "" "" "" "" "" "" "" "" "" "1602.6" "1528.7" "1576.8" "1406.5" "1540.2" "1615.4" "1505.2" "1378.0" "1525.5" "1243.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.000" "False" "67.865" "48" "6" "23" "6" "154" "17.3" "6.33" "90.04" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.954" "1.035" "0.939" "0.978" "1.000" "0.987" "0.997" "0.996" "0.478" "3639.6" "3471.5" "3768.0" "3418.7" "3557.7" "3639.2" "3594.0" "3628.6" "3624.7" "1738.7" "" "" "" "" "" "" "" "" "" "" "3227.5" "2875.7" "3287.7" "2556.8" "2966.7" "3343.0" "3037.5" "2999.3" "3324.3" "1738.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "67.856" "31" "7" "28" "7" "256" "27.7" "7.78" "102.21" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Detoxification of Reactive Oxygen Species" "Selenium micronutrient network" "2" "0" "0.937" "0.947" "0.984" "0.972" "1.042" "1.038" "1.033" "1.025" "0.351" "2011.8" "1886.0" "1904.8" "1979.8" "1955.8" "2096.7" "2087.9" "2077.8" "2061.2" "707.1" "" "" "" "" "" "" "" "" "" "" "1784.0" "1562.2" "1662.0" "1480.6" "1630.8" "1926.0" "1764.6" "1717.4" "1890.4" "707.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "67.856" "27" "9" "15" "9" "348" "38.3" "6.73" "63.47" "9" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Galactose catabolism; Defective GALE causes EDG" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "4" "0" "1.039" "1.003" "1.155" "1.071" "1.073" "1.059" "1.090" "0.917" "0.543" "1281.7" "1331.7" "1285.1" "1480.7" "1372.6" "1375.2" "1357.9" "1396.9" "1175.4" "696.1" "" "" "" "" "" "" "" "" "" "" "1136.6" "1103.1" "1121.3" "1107.3" "1144.5" "1263.3" "1147.7" "1154.6" "1078.0" "696.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174498408520760419" "False" "High" "IsMasterProtein" "Q02241" "Kinesin-like protein KIF23 OS=Homo sapiens OX=9606 GN=KIF23 PE=1 SV=3" "0.000" "False" "67.839" "17" "14" "16" "14" "960" "110.0" "8.51" "60.40" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf16540" "9493" "ENSG00000137807" "KIF23" "B4E1K0; hsa:9493; Q02241; Q8WVP0" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Mitotic Telophase/Cytokinesis" "Pleural mesothelioma" "5" "0" "0.954" "0.893" "0.955" "0.889" "0.823" "0.933" "0.787" "0.896" "2.319" "1388.7" "1324.7" "1239.7" "1325.6" "1234.0" "1142.3" "1295.5" "1092.8" "1243.8" "3220.2" "" "" "" "" "" "" "" "" "" "" "1231.5" "1097.3" "1081.7" "991.4" "1029.0" "1049.3" "1094.9" "903.3" "1140.7" "3220.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "67.730" "31" "9" "23" "9" "313" "34.0" "4.87" "80.24" "9" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "0.956" "0.949" "0.841" "0.856" "0.916" "0.863" "0.819" "0.922" "1.819" "3292.5" "3146.7" "3124.4" "2769.6" "2819.0" "3016.7" "2840.1" "2696.9" "3036.1" "5990.7" "" "" "" "" "" "" "" "" "" "" "2919.7" "2606.5" "2726.2" "2071.3" "2350.6" "2771.2" "2400.3" "2229.2" "2784.5" "5990.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4563498728879559184" "False" "High" "IsMasterProtein" "Q9BW71" "HIRA-interacting protein 3 OS=Homo sapiens OX=9606 GN=HIRIP3 PE=1 SV=3" "0.000" "False" "67.723" "19" "12" "13" "12" "556" "61.9" "8.54" "50.33" "12" "cell organization and biogenesis" "nucleus" "" "Pf09649" "8479" "ENSG00000149929" "HIRIP3" "H3BSR3; hsa:8479; O75707; O75708; Q9BW71" "" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "2" "0" "0.966" "0.983" "1.041" "0.943" "1.084" "0.963" "0.981" "1.086" "0.518" "939.2" "907.5" "923.6" "977.6" "885.3" "1018.1" "904.6" "921.1" "1019.7" "486.8" "" "" "" "" "" "" "" "" "" "" "832.9" "751.8" "805.9" "731.1" "738.2" "935.2" "764.5" "761.4" "935.2" "486.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "67.549" "30" "8" "14" "7" "322" "34.9" "6.44" "59.90" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "" "Exercise-induced circadian regulation" "1" "0" "1.017" "1.072" "0.946" "1.070" "1.134" "1.020" "1.105" "1.053" "0.588" "1472.8" "1498.3" "1578.1" "1393.9" "1576.5" "1670.6" "1502.8" "1627.7" "1551.5" "866.1" "" "" "" "" "" "" "" "" "" "" "1306.1" "1241.2" "1377.0" "1042.4" "1314.6" "1534.6" "1270.1" "1345.4" "1422.9" "866.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "67.481" "38" "12" "13" "12" "380" "43.2" "9.33" "55.75" "12" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "16" "0" "0.992" "1.004" "0.999" "1.020" "0.979" "0.994" "0.973" "1.031" "1.194" "1409.4" "1398.1" "1414.7" "1408.5" "1437.8" "1380.0" "1401.4" "1371.3" "1453.3" "1682.7" "" "" "" "" "" "" "" "" "" "" "1249.8" "1158.1" "1234.4" "1053.4" "1198.9" "1267.7" "1184.4" "1133.5" "1332.8" "1682.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "67.471" "19" "12" "19" "12" "703" "76.2" "6.48" "76.39" "12" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "6" "0" "0.967" "0.934" "1.001" "0.960" "0.934" "0.910" "0.915" "0.916" "0.663" "1187.2" "1148.2" "1108.7" "1188.8" "1139.7" "1109.2" "1080.9" "1085.8" "1087.8" "786.7" "" "" "" "" "" "" "" "" "" "" "1052.8" "951.1" "967.4" "889.0" "950.4" "1019.0" "913.6" "897.5" "997.7" "786.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.000" "False" "67.440" "28" "11" "13" "11" "542" "59.6" "9.35" "51.13" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "17" "0" "1.060" "1.060" "0.974" "0.936" "1.019" "0.869" "0.701" "0.892" "4.324" "599.7" "635.5" "635.7" "584.1" "561.3" "611.2" "521.2" "420.5" "534.8" "2593.3" "" "" "" "" "" "" "" "" "" "" "531.8" "526.4" "554.7" "436.8" "468.0" "561.4" "440.5" "347.5" "490.5" "2593.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5446146544739154360" "False" "High" "IsMasterProtein" "Q15654" "Thyroid receptor-interacting protein 6 OS=Homo sapiens OX=9606 GN=TRIP6 PE=1 SV=3" "0.000" "False" "67.428" "33" "11" "12" "11" "476" "50.3" "7.37" "55.97" "11" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00412" "7205" "ENSG00000087077" "TRIP6" "A4D2E7; F2ZC07; F2ZC08; hsa:7205; O15170; O15275; Q15654; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4" "" "" "0" "0" "0.938" "0.958" "0.969" "0.929" "0.950" "0.889" "0.922" "0.938" "0.768" "1124.6" "1054.8" "1077.8" "1089.2" "1044.7" "1068.5" "999.5" "1037.4" "1055.0" "863.5" "" "" "" "" "" "" "" "" "" "" "997.3" "873.8" "940.4" "814.6" "871.1" "981.5" "844.8" "857.5" "967.5" "863.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "67.286" "23" "12" "14" "12" "642" "72.9" "5.87" "52.60" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "1.111" "1.068" "1.101" "1.053" "1.066" "1.128" "1.032" "1.150" "3.848" "607.3" "674.9" "648.8" "668.8" "639.5" "647.2" "685.0" "627.0" "698.2" "2337.1" "" "" "" "" "" "" "" "" "" "" "538.6" "559.1" "566.1" "500.2" "533.3" "594.6" "578.9" "518.2" "640.3" "2337.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "67.280" "32" "8" "20" "8" "268" "30.0" "5.14" "78.28" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; The role of GTSE1 in G2/M progression after G2 checkpoint; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "16" "0" "0.971" "0.994" "0.831" "0.930" "0.981" "0.930" "0.948" "0.947" "1.094" "2476.8" "2405.0" "2462.3" "2059.0" "2302.4" "2429.5" "2302.2" "2348.9" "2346.2" "2708.5" "" "" "" "" "" "" "" "" "" "" "2196.4" "1992.2" "2148.5" "1539.9" "1919.9" "2231.8" "1945.7" "1941.5" "2151.8" "2708.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7482733620363159602" "False" "High" "IsMasterProtein" "Q9BVS5" "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2" "0.000" "False" "66.980" "23" "10" "18" "10" "477" "52.9" "6.62" "67.41" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf08704" "55006" "ENSG00000171103" "TRMT61B" "hsa:55006; Q9BVS5; Q9H0Q9; Q9NWS7" "tRNA modification in the mitochondrion" "" "1" "0" "1.025" "1.035" "1.090" "1.064" "1.012" "1.053" "1.012" "1.001" "0.510" "1731.3" "1774.0" "1791.8" "1887.6" "1841.2" "1752.5" "1822.8" "1751.7" "1733.0" "883.6" "" "" "" "" "" "" "" "" "" "" "1535.2" "1469.5" "1563.4" "1411.7" "1535.3" "1609.8" "1540.6" "1447.9" "1589.4" "883.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "66.965" "40" "13" "21" "12" "301" "33.4" "5.60" "68.06" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "Neutrophil degranulation; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "6" "1" "0.938" "0.943" "0.903" "0.838" "0.888" "0.838" "0.898" "0.939" "0.659" "3312.7" "3107.3" "3123.5" "2990.8" "2776.2" "2941.7" "2777.0" "2974.0" "3110.2" "2182.6" "" "" "" "" "" "" "" "" "" "" "2937.7" "2574.0" "2725.4" "2236.7" "2315.0" "2702.3" "2347.0" "2458.3" "2852.4" "2182.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2093622632730469128" "False" "High" "IsMasterProtein" "Q15418" "Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2" "0.000" "False" "66.957" "21" "13" "16" "9" "735" "82.7" "7.83" "63.22" "13" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6195" "ENSG00000117676; ENSG00000281877" "RPS6KA1" "A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4; hsa:6195; Q15418; Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2" "Recycling pathway of L1; Senescence-Associated Secretory Phenotype (SASP); RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; TYROBP causal network in microglia; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map" "26" "1" "0.942" "0.946" "0.969" "0.927" "0.922" "0.972" "0.775" "0.913" "3.124" "922.5" "868.6" "872.8" "893.6" "854.7" "850.3" "896.8" "714.6" "842.7" "2882.2" "" "" "" "" "" "" "" "" "" "" "818.0" "719.5" "761.5" "668.3" "712.7" "781.1" "757.9" "590.7" "772.8" "2882.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5358245641494386502" "False" "High" "IsMasterProtein" "Q14012" "Calcium/calmodulin-dependent protein kinase type 1 OS=Homo sapiens OX=9606 GN=CAMK1 PE=1 SV=1" "0.000" "False" "66.851" "28" "8" "14" "8" "370" "41.3" "5.29" "51.31" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00069" "8536" "ENSG00000134072" "CAMK1" "hsa:8536; Q14012; Q3KPF6" "Negative regulation of NMDA receptor-mediated neuronal transmission; Activation of RAC1 downstream of NMDARs" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Physico-chemical features and toxicity-associated pathways; Clear cell renal cell carcinoma pathways; Fragile X syndrome; CAMKK2 pathway; Calcium regulation in cardiac cells" "8" "0" "1.051" "1.042" "0.990" "1.055" "0.970" "1.162" "1.030" "1.074" "1.236" "822.7" "865.0" "857.3" "814.7" "867.9" "798.3" "955.8" "847.2" "883.8" "1016.9" "" "" "" "" "" "" "" "" "" "" "729.6" "716.6" "748.0" "609.3" "723.7" "733.3" "807.8" "700.3" "810.6" "1016.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "High" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.000" "False" "66.838" "24" "11" "14" "11" "538" "60.6" "7.24" "56.74" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "0.998" "0.964" "0.984" "0.970" "0.970" "0.950" "0.881" "0.939" "1.973" "1163.6" "1160.8" "1122.2" "1144.8" "1128.9" "1128.8" "1105.4" "1025.1" "1093.2" "2295.5" "" "" "" "" "" "" "" "" "" "" "1031.8" "961.5" "979.2" "856.2" "941.4" "1036.9" "934.2" "847.3" "1002.6" "2295.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "66.834" "30" "6" "14" "6" "257" "26.9" "11.15" "59.10" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "" "7" "0" "0.965" "1.001" "1.007" "0.917" "0.900" "1.005" "0.915" "0.935" "0.440" "1502.2" "1449.4" "1503.3" "1512.8" "1378.2" "1351.7" "1510.3" "1374.0" "1404.5" "661.7" "" "" "" "" "" "" "" "" "" "" "1332.2" "1200.6" "1311.7" "1131.3" "1149.2" "1241.7" "1276.5" "1135.7" "1288.1" "661.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027894993262294813" "False" "High" "IsMasterProtein" "Q13131" "5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4" "0.000" "False" "66.824" "24" "11" "15" "11" "559" "64.0" "8.12" "59.06" "11" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf16579, Pf21147" "5562" "ENSG00000132356" "PRKAA1" "A8MTQ6; B2R7E1; hsa:5562; O00286; Q13131; Q5D0E1; Q86VS1; Q9UNQ4" "Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Thyroxine (thyroid hormone) production; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation ; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Pleural mesothelioma; Affected pathways in Duchenne muscular dystrophy; ADHD and autism (ASD) linked metabolic pathways and SNP" "36" "0" "1.005" "0.999" "0.972" "0.963" "0.962" "0.968" "1.018" "1.012" "1.007" "1002.7" "1007.9" "1002.1" "974.4" "965.4" "964.9" "970.1" "1021.1" "1015.1" "1009.5" "" "" "" "" "" "" "" "" "" "" "889.2" "834.9" "874.4" "728.7" "805.0" "886.3" "819.9" "844.1" "930.9" "1009.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "66.785" "30" "11" "15" "11" "445" "48.1" "7.12" "55.57" "11" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "3" "0" "0.980" "0.976" "0.975" "0.995" "1.026" "0.990" "1.000" "0.971" "0.562" "1392.4" "1364.7" "1359.4" "1357.1" "1385.1" "1428.2" "1378.1" "1392.6" "1352.4" "782.9" "" "" "" "" "" "" "" "" "" "" "1234.8" "1130.4" "1186.2" "1015.0" "1155.0" "1312.0" "1164.7" "1151.1" "1240.4" "782.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749149961980637251" "False" "High" "IsMasterProtein" "P27361" "Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4" "0.000" "False" "66.679" "39" "14" "19" "9" "379" "43.1" "6.74" "66.00" "14" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "5595" "ENSG00000102882" "MAPK3" "A8CZ58; B0LPG3; hsa:5595; P27361; Q8NHX1" "FCGR3A-mediated phagocytosis; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; NCAM signaling for neurite out-growth; ISG15 antiviral mechanism; Signal transduction by L1; Suppression of apoptosis; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Polycystic kidney disease pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; 2q11.2 copy number variation syndrome; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "178" "0" "0.998" "1.020" "1.059" "0.979" "1.047" "1.199" "1.090" "1.082" "1.868" "601.1" "599.6" "613.4" "636.7" "588.3" "629.6" "720.8" "655.2" "650.2" "1122.7" "" "" "" "" "" "" "" "" "" "" "533.0" "496.7" "535.2" "476.2" "490.6" "578.4" "609.2" "541.5" "596.3" "1122.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "66.559" "28" "9" "20" "9" "346" "39.0" "8.47" "80.28" "9" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "RNA polymerase II transcribes snRNA genes; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "43" "0" "1.031" "1.015" "1.092" "1.023" "1.013" "1.004" "1.016" "0.967" "0.657" "1854.5" "1912.0" "1883.0" "2025.8" "1896.2" "1878.8" "1861.7" "1884.6" "1792.4" "1218.7" "" "" "" "" "" "" "" "" "" "" "1644.5" "1583.8" "1643.1" "1515.0" "1581.2" "1725.8" "1573.5" "1557.8" "1643.9" "1218.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "66.545" "40" "12" "43" "12" "246" "29.1" "9.72" "130.53" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Mitochondrial protein degradation; Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "9" "0" "0.887" "0.886" "0.860" "0.790" "0.799" "0.686" "0.831" "0.837" "0.361" "7707.6" "6837.1" "6826.2" "6626.3" "6091.6" "6157.1" "5290.8" "6405.7" "6451.2" "2781.4" "" "" "" "" "" "" "" "" "" "" "6835.0" "5663.5" "5956.2" "4955.6" "5079.6" "5655.9" "4471.6" "5294.8" "5916.6" "2781.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "66.526" "23" "16" "19" "14" "620" "69.9" "5.59" "70.12" "16" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "6" "0" "1.034" "0.876" "0.965" "0.897" "0.877" "0.885" "0.855" "0.873" "0.725" "1992.9" "2060.9" "1746.1" "1923.2" "1787.6" "1747.6" "1763.0" "1704.4" "1740.4" "1443.9" "" "" "" "" "" "" "" "" "" "" "1767.3" "1707.1" "1523.6" "1438.3" "1490.7" "1605.4" "1490.0" "1408.8" "1596.2" "1443.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "66.500" "57" "7" "18" "7" "135" "14.7" "5.50" "70.33" "7" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Immune infiltration in pancreatic cancer" "3" "0" "0.945" "0.993" "0.962" "0.973" "1.102" "0.975" "0.962" "0.991" "0.538" "2991.1" "2827.0" "2969.4" "2878.7" "2910.6" "3296.2" "2915.6" "2876.8" "2962.7" "1608.2" "" "" "" "" "" "" "" "" "" "" "2652.5" "2341.8" "2590.9" "2152.9" "2427.1" "3027.9" "2464.1" "2377.9" "2717.2" "1608.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "66.380" "22" "8" "24" "3" "453" "52.0" "6.39" "87.04" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "MASTL Facilitates Mitotic Progression" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "3" "0" "0.790" "0.928" "1.007" "1.176" "1.184" "0.922" "0.898" "0.948" "1.387" "84.0" "66.4" "78.0" "84.6" "98.8" "99.5" "77.5" "75.5" "79.7" "116.6" "" "" "" "" "" "" "" "" "" "" "74.5" "55.0" "68.1" "63.3" "82.4" "91.4" "65.5" "62.4" "73.1" "116.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "309589120852016759" "False" "High" "IsMasterProtein" "P54922" "ADP-ribosylhydrolase ARH1 OS=Homo sapiens OX=9606 GN=ADPRH PE=1 SV=1" "0.000" "False" "66.328" "28" "8" "20" "8" "357" "39.5" "6.52" "63.55" "8" "protein metabolism;other metabolic processes" "non-structural extracellular" "other molecular function" "Pf03747" "141" "ENSG00000144843" "ADPRH" "B2R8H1; D3DN83; hsa:141; P54922" "" "" "0" "0" "0.996" "0.980" "1.025" "1.046" "1.052" "1.008" "1.049" "0.958" "0.659" "1491.4" "1486.1" "1461.3" "1529.4" "1560.3" "1569.4" "1502.6" "1563.8" "1428.7" "983.2" "" "" "" "" "" "" "" "" "" "" "1322.5" "1231.0" "1275.1" "1143.8" "1301.1" "1441.6" "1269.9" "1292.6" "1310.3" "983.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "66.286" "14" "18" "26" "18" "1220" "132.9" "6.89" "80.78" "18" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "6" "0" "1.154" "1.092" "1.065" "1.021" "1.009" "0.992" "0.829" "1.143" "4.035" "1745.3" "2014.1" "1906.7" "1859.1" "1782.7" "1760.3" "1732.1" "1446.8" "1994.4" "7041.7" "" "" "" "" "" "" "" "" "" "" "1547.7" "1668.4" "1663.7" "1390.4" "1486.6" "1617.0" "1463.9" "1195.9" "1829.1" "7041.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491250249564736583" "False" "High" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "0.000" "False" "66.256" "20" "11" "18" "11" "561" "64.9" "6.14" "70.58" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "" "3" "0" "0.994" "1.001" "1.029" "1.060" "1.071" "1.091" "1.064" "0.947" "0.632" "2177.6" "2163.9" "2180.4" "2240.5" "2308.7" "2332.3" "2375.3" "2316.2" "2061.6" "1376.3" "" "" "" "" "" "" "" "" "" "" "1931.0" "1792.5" "1902.5" "1675.6" "1925.1" "2142.5" "2007.5" "1914.5" "1890.8" "1376.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5199956621996248182" "False" "High" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "0.000" "False" "66.249" "39" "4" "9" "4" "108" "12.6" "9.52" "43.14" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "5" "0" "1.048" "1.025" "1.066" "1.069" "1.123" "1.091" "1.136" "1.122" "0.359" "915.8" "959.3" "938.8" "976.6" "979.0" "1028.4" "999.6" "1040.3" "1027.7" "328.7" "" "" "" "" "" "" "" "" "" "" "812.1" "794.7" "819.1" "730.3" "816.4" "944.7" "844.8" "859.9" "942.5" "328.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "66.227" "38" "10" "15" "10" "323" "37.6" "7.15" "62.45" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "39" "0" "0.968" "0.942" "1.012" "0.966" "0.988" "0.977" "0.942" "0.788" "0.658" "1346.7" "1303.0" "1269.1" "1363.2" "1300.3" "1330.9" "1315.2" "1268.6" "1061.0" "885.6" "" "" "" "" "" "" "" "" "" "" "1194.2" "1079.3" "1107.3" "1019.5" "1084.2" "1222.6" "1111.6" "1048.6" "973.1" "885.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "66.137" "12" "15" "15" "14" "1354" "158.1" "5.90" "50.71" "15" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; EPHB-mediated forward signaling; Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; RND3 GTPase cycle; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle; Apoptotic cleavage of cellular proteins" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "35" "0" "1.031" "0.981" "1.038" "0.990" "1.019" "0.976" "0.834" "1.004" "3.097" "1420.2" "1463.6" "1393.8" "1474.2" "1406.3" "1447.9" "1385.9" "1184.0" "1425.5" "4398.0" "" "" "" "" "" "" "" "" "" "" "1259.4" "1212.4" "1216.2" "1102.5" "1172.7" "1330.0" "1171.3" "978.7" "1307.4" "4398.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "66.131" "26" "6" "16" "6" "320" "34.5" "5.33" "51.09" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis" "2" "0" "0.931" "0.993" "1.049" "0.959" "0.945" "1.054" "1.039" "0.993" "0.636" "791.0" "736.0" "785.8" "829.7" "758.3" "747.1" "833.7" "821.6" "785.4" "502.7" "" "" "" "" "" "" "" "" "" "" "701.4" "609.7" "685.6" "620.5" "632.4" "686.3" "704.6" "679.1" "720.4" "502.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210442272290705579" "False" "High" "IsMasterProtein" "P09493" "Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2" "0.000" "False" "66.052" "35" "13" "34" "3" "284" "32.7" "4.74" "106.63" "13" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00261" "7168" "ENSG00000140416" "TPM1" "B7Z5T7; D9YZV2; D9YZV3; D9YZV8; hsa:7168; P09493; P09494; P10469; Q6DV89; Q6DV90; Q7Z6L8; Q86W64; Q96IK2; Q9UCI1; Q9UCI2; Q9UCY9; Q9Y427" "Smooth Muscle Contraction; Striated Muscle Contraction" "Vitamin D receptor pathway; Striated muscle contraction pathway; Cell lineage map for neuronal differentiation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7154338873387211180" "False" "High" "IsMasterProtein" "Q8TDQ7" "Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1" "0.000" "False" "66.028" "40" "7" "12" "4" "276" "31.1" "6.95" "53.72" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01182" "132789" "ENSG00000163281" "GNPDA2" "B4DJF3; hsa:132789; Q2VYF1; Q59EA7; Q8NCZ8; Q8TDQ7; Q96BJ4; Q96NC6" "Glycolysis" "" "1" "0" "1.055" "1.030" "1.131" "1.051" "1.053" "1.143" "1.127" "1.001" "0.519" "430.0" "453.7" "442.7" "486.3" "451.8" "452.7" "491.4" "484.6" "430.4" "223.2" "" "" "" "" "" "" "" "" "" "" "381.3" "375.8" "386.3" "363.7" "376.8" "415.9" "415.3" "400.6" "394.7" "223.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "66.008" "31" "13" "15" "13" "572" "61.2" "6.67" "63.50" "13" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "" "Integrin-mediated cell adhesion; Focal adhesion" "2" "0" "0.993" "0.880" "0.889" "0.858" "0.871" "1.005" "0.931" "0.892" "0.466" "1892.3" "1878.6" "1665.1" "1681.5" "1624.4" "1649.0" "1902.7" "1761.5" "1688.7" "882.0" "" "" "" "" "" "" "" "" "" "" "1678.1" "1556.1" "1452.8" "1257.5" "1354.6" "1514.7" "1608.1" "1456.0" "1548.7" "882.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "65.954" "40" "9" "21" "9" "217" "24.8" "9.94" "78.57" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.952" "1.032" "0.957" "1.051" "1.157" "1.066" "1.047" "1.028" "0.359" "3088.1" "2940.9" "3187.4" "2954.1" "3246.7" "3572.7" "3292.7" "3232.5" "3174.7" "1109.2" "" "" "" "" "" "" "" "" "" "" "2738.5" "2436.1" "2781.1" "2209.2" "2707.3" "3282.0" "2782.9" "2671.9" "2911.6" "1109.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "65.894" "18" "8" "10" "8" "528" "60.6" "5.06" "45.27" "8" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.967" "0.984" "0.962" "1.002" "0.964" "0.989" "0.890" "0.926" "2.068" "744.1" "719.2" "732.2" "715.7" "745.8" "717.3" "735.7" "662.1" "689.2" "1538.7" "" "" "" "" "" "" "" "" "" "" "659.9" "595.8" "638.9" "535.3" "621.9" "658.9" "621.7" "547.3" "632.1" "1538.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7032726270839277036" "False" "High" "IsMasterProtein" "P27144" "Adenylate kinase 4, mitochondrial OS=Homo sapiens OX=9606 GN=AK4 PE=1 SV=1" "0.000" "False" "65.890" "45" "9" "26" "9" "223" "25.3" "8.40" "89.67" "9" "other metabolic processes;stress response;other biological processes" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "205" "ENSG00000162433" "AK4" "B2R927; D3DQ62; hsa:205; P27144; Q6IBH4; Q6NXQ5; Q8IUU9" "Interconversion of nucleotide di- and triphosphates" "CCL18 signaling pathway" "2" "0" "1.019" "0.995" "1.011" "1.059" "1.033" "1.055" "1.059" "1.006" "0.485" "3278.1" "3338.9" "3262.2" "3314.5" "3470.1" "3385.4" "3457.9" "3471.0" "3297.5" "1590.6" "" "" "" "" "" "" "" "" "" "" "2906.9" "2765.8" "2846.5" "2478.8" "2893.6" "3109.9" "2922.5" "2869.1" "3024.3" "1590.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "High" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.000" "False" "65.855" "23" "6" "14" "6" "376" "42.5" "5.57" "68.28" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "mRNA Splicing - Major Pathway" "" "1" "0" "0.964" "0.958" "0.948" "0.962" "1.039" "0.952" "0.989" "1.007" "0.521" "2334.2" "2250.1" "2235.3" "2213.0" "2246.5" "2424.6" "2221.0" "2308.6" "2350.2" "1216.2" "" "" "" "" "" "" "" "" "" "" "2069.9" "1863.8" "1950.4" "1655.0" "1873.2" "2227.3" "1877.1" "1908.2" "2155.4" "1216.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "65.808" "18" "12" "16" "12" "727" "83.9" "6.38" "61.36" "12" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "" "Primary ovarian insufficiency" "1" "0" "1.010" "0.987" "1.067" "1.065" "1.114" "1.145" "1.214" "1.050" "0.825" "1519.5" "1534.1" "1499.1" "1621.1" "1618.2" "1693.5" "1739.6" "1844.0" "1595.2" "1253.3" "" "" "" "" "" "" "" "" "" "" "1347.5" "1270.7" "1308.1" "1212.3" "1349.4" "1555.6" "1470.2" "1524.2" "1463.0" "1253.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "65.799" "52" "6" "24" "6" "163" "17.2" "9.16" "105.38" "6" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "RHOD GTPase cycle" "" "1" "0" "1.030" "1.009" "1.042" "1.022" "0.982" "0.994" "1.005" "1.002" "0.452" "2494.3" "2570.3" "2517.6" "2599.3" "2549.2" "2450.3" "2479.0" "2506.6" "2500.4" "1127.2" "" "" "" "" "" "" "" "" "" "" "2211.9" "2129.1" "2196.7" "1943.9" "2125.7" "2250.9" "2095.1" "2071.9" "2293.2" "1127.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "65.746" "18" "11" "12" "11" "805" "87.7" "4.88" "53.20" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "1.043" "1.013" "1.029" "1.049" "0.990" "1.077" "1.069" "1.110" "0.721" "1355.4" "1413.9" "1373.0" "1394.1" "1422.3" "1341.9" "1459.5" "1449.4" "1503.9" "977.6" "" "" "" "" "" "" "" "" "" "" "1202.0" "1171.2" "1198.0" "1042.6" "1186.0" "1232.7" "1233.5" "1198.1" "1379.3" "977.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "65.631" "30" "10" "24" "7" "351" "40.7" "4.97" "83.87" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "6" "0" "0.996" "1.008" "1.036" "1.054" "1.040" "1.039" "1.033" "0.989" "0.547" "1016.9" "1012.5" "1025.3" "1053.9" "1071.8" "1057.1" "1056.3" "1050.5" "1006.1" "556.5" "" "" "" "" "" "" "" "" "" "" "901.7" "838.7" "894.6" "788.2" "893.7" "971.1" "892.8" "868.3" "922.7" "556.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4307491490075501206" "False" "High" "IsMasterProtein" "P32322" "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" "0.000" "False" "65.620" "44" "11" "14" "10" "319" "33.3" "7.61" "55.11" "11" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "5831" "ENSG00000183010" "PYCR1" "A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4" "Glutamate and glutamine metabolism" "Amino acid metabolism; Metabolic reprogramming in colon cancer" "3" "1" "0.974" "0.981" "0.977" "0.922" "0.863" "0.811" "0.932" "0.960" "0.584" "1186.9" "1155.5" "1164.8" "1159.4" "1094.1" "1024.5" "962.9" "1106.0" "1139.4" "693.5" "" "" "" "" "" "" "" "" "" "" "1052.6" "957.2" "1016.3" "867.1" "912.3" "941.2" "813.8" "914.2" "1045.0" "693.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2576467063852337379" "False" "High" "IsMasterProtein" "Q12912" "Inositol 1,4,5-triphosphate receptor associated 2 OS=Homo sapiens OX=9606 GN=IRAG2 PE=1 SV=3" "0.000" "False" "65.519" "26" "14" "20" "14" "555" "62.1" "5.85" "77.09" "14" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf05781" "4033" "ENSG00000118308" "IRAG2" "A0AVM2; B4E077; hsa:4033; Q12912; Q8N301" "Neutrophil degranulation" "" "1" "0" "0.972" "1.002" "0.959" "0.957" "0.925" "0.931" "0.884" "0.947" "0.757" "2120.8" "2060.6" "2124.7" "2034.3" "2030.3" "1960.8" "1974.1" "1874.8" "2009.2" "1605.6" "" "" "" "" "" "" "" "" "" "" "1880.7" "1706.9" "1853.9" "1521.4" "1693.0" "1801.2" "1668.4" "1549.7" "1842.7" "1605.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "High" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.000" "False" "65.439" "24" "14" "18" "14" "578" "65.5" "8.21" "65.50" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.098" "1.038" "1.143" "1.118" "1.038" "1.152" "1.074" "1.081" "0.778" "1774.2" "1947.5" "1842.0" "2027.7" "1983.5" "1841.5" "2044.3" "1904.6" "1917.2" "1380.7" "" "" "" "" "" "" "" "" "" "" "1573.3" "1613.2" "1607.3" "1516.5" "1654.0" "1691.7" "1727.8" "1574.3" "1758.3" "1380.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "65.414" "25" "14" "17" "14" "603" "68.2" "8.91" "57.91" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Mitotic Telophase/Cytokinesis; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "30" "0" "1.058" "1.024" "1.072" "1.088" "1.025" "0.947" "0.924" "0.933" "0.881" "1562.6" "1653.2" "1600.7" "1674.7" "1700.1" "1601.8" "1480.0" "1443.4" "1458.5" "1377.2" "" "" "" "" "" "" "" "" "" "" "1385.7" "1369.4" "1396.7" "1252.4" "1417.6" "1471.5" "1250.9" "1193.1" "1337.7" "1377.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3455107625301328378" "False" "High" "IsMasterProtein" "Q86TX2" "Acyl-coenzyme A thioesterase 1 OS=Homo sapiens OX=9606 GN=ACOT1 PE=1 SV=1" "0.000" "False" "65.369" "33" "11" "13" "11" "421" "46.2" "7.34" "51.35" "11" "other metabolic processes" "cytosol" "other molecular function" "Pf04775, Pf08840" "641371" "ENSG00000184227" "ACOT1" "A1L173; hsa:641371; Q3I5F9; Q86TX2" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.056" "0.988" "1.062" "0.998" "0.940" "1.068" "1.010" "0.993" "1.520" "815.0" "860.6" "805.5" "865.4" "813.4" "766.1" "870.4" "823.1" "809.0" "1239.1" "" "" "" "" "" "" "" "" "" "" "722.7" "712.9" "702.9" "647.2" "678.3" "703.8" "735.7" "680.3" "742.0" "1239.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.000" "False" "65.302" "28" "7" "12" "7" "360" "39.8" "6.61" "47.58" "7" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "Synthesis of GDP-mannose" "N-glycan biosynthesis" "2" "0" "0.996" "0.993" "1.065" "1.124" "0.995" "1.090" "1.046" "0.944" "0.582" "951.2" "947.9" "944.6" "1012.8" "1069.2" "946.8" "1037.0" "995.4" "897.8" "553.7" "" "" "" "" "" "" "" "" "" "" "843.5" "785.2" "824.2" "757.4" "891.6" "869.7" "876.4" "822.8" "823.4" "553.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "65.285" "36" "8" "20" "8" "245" "26.4" "6.52" "74.15" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.135" "0.995" "1.063" "1.131" "1.032" "1.067" "1.040" "0.956" "0.592" "2365.6" "2684.0" "2353.1" "2514.8" "2676.2" "2440.5" "2523.1" "2460.6" "2261.6" "1400.2" "" "" "" "" "" "" "" "" "" "" "2097.8" "2223.3" "2053.2" "1880.7" "2231.6" "2241.9" "2132.4" "2033.9" "2074.2" "1400.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "65.280" "18" "11" "13" "11" "684" "77.4" "5.60" "48.91" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "1.037" "0.973" "1.022" "0.956" "0.938" "0.992" "0.962" "0.948" "1.760" "1303.3" "1351.5" "1267.9" "1331.4" "1246.0" "1222.9" "1292.3" "1254.0" "1234.9" "2293.9" "" "" "" "" "" "" "" "" "" "" "1155.8" "1119.5" "1106.3" "995.7" "1039.0" "1123.4" "1092.2" "1036.6" "1132.6" "2293.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "65.252" "66" "7" "26" "7" "123" "13.9" "5.52" "88.35" "7" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "1.029" "1.080" "1.048" "1.021" "0.999" "1.050" "1.054" "1.050" "0.823" "1772.0" "1822.7" "1913.5" "1856.3" "1808.6" "1770.5" "1860.0" "1868.4" "1860.6" "1457.8" "" "" "" "" "" "" "" "" "" "" "1571.3" "1509.8" "1669.6" "1388.3" "1508.1" "1626.4" "1572.0" "1544.4" "1706.4" "1457.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "65.249" "33" "9" "11" "9" "356" "38.1" "9.83" "47.77" "9" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "1.078" "1.028" "1.185" "1.106" "1.026" "1.126" "1.062" "0.944" "0.637" "851.3" "918.1" "875.3" "1008.6" "941.8" "873.8" "958.9" "904.0" "803.5" "542.6" "" "" "" "" "" "" "" "" "" "" "754.9" "760.5" "763.7" "754.3" "785.3" "802.6" "810.4" "747.2" "736.9" "542.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4785395366368004219" "False" "High" "IsMasterProtein" "Q15274" "Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens OX=9606 GN=QPRT PE=1 SV=3" "0.000" "False" "65.158" "34" "8" "15" "8" "297" "30.8" "6.21" "58.95" "8" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01729, Pf02749" "23475" "ENSG00000103485" "QPRT" "hsa:23475; Q15274; Q53XW7; Q96G22; Q9BSG6" "Nicotinate metabolism" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome; Kynurenine pathway and links to cell senescence" "5" "0" "1.013" "1.022" "1.071" "1.086" "1.030" "1.091" "1.077" "1.013" "0.566" "2008.5" "2035.0" "2052.4" "2152.0" "2180.9" "2069.3" "2192.0" "2163.0" "2035.6" "1135.9" "" "" "" "" "" "" "" "" "" "" "1781.1" "1685.7" "1790.8" "1609.4" "1818.6" "1900.9" "1852.6" "1787.9" "1866.9" "1135.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "High" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.000" "False" "65.138" "51" "6" "12" "6" "133" "15.2" "5.22" "60.07" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.077" "1.073" "1.152" "1.020" "1.025" "1.096" "1.102" "1.080" "0.476" "861.1" "927.4" "923.8" "991.9" "878.7" "882.2" "943.5" "949.0" "929.6" "410.1" "" "" "" "" "" "" "" "" "" "" "763.6" "768.2" "806.0" "741.8" "732.7" "810.4" "797.4" "784.4" "852.6" "410.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "65.048" "41" "10" "16" "10" "275" "30.3" "8.22" "64.50" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "Ciliary landscape" "5" "0" "1.063" "1.020" "1.120" "1.125" "1.078" "1.130" "1.048" "0.933" "0.549" "1121.3" "1191.9" "1144.1" "1256.2" "1261.8" "1208.5" "1267.6" "1174.7" "1045.9" "615.6" "" "" "" "" "" "" "" "" "" "" "994.4" "987.3" "998.3" "939.5" "1052.2" "1110.2" "1071.3" "971.0" "959.2" "615.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "65.018" "78" "6" "22" "6" "126" "13.8" "6.95" "88.77" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "1.005" "1.003" "1.017" "0.952" "0.937" "1.010" "0.938" "0.940" "0.519" "2126.7" "2137.4" "2133.7" "2163.8" "2024.1" "1992.1" "2148.7" "1995.8" "1999.3" "1102.7" "" "" "" "" "" "" "" "" "" "" "1885.9" "1770.5" "1861.8" "1618.3" "1687.8" "1829.9" "1816.0" "1649.7" "1833.6" "1102.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-849081801659546262" "False" "High" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "0.000" "False" "65.006" "41" "15" "20" "15" "357" "41.4" "8.78" "66.78" "15" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "" "Cholesterol metabolism" "1" "0" "0.996" "0.961" "0.991" "0.959" "0.942" "0.979" "0.971" "0.947" "0.461" "1938.8" "1931.5" "1862.8" "1920.9" "1860.0" "1825.5" "1898.9" "1882.2" "1835.8" "894.3" "" "" "" "" "" "" "" "" "" "" "1719.3" "1600.0" "1625.4" "1436.6" "1551.0" "1676.9" "1604.8" "1555.8" "1683.7" "894.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.000" "False" "64.997" "45" "10" "13" "10" "222" "25.6" "8.73" "49.00" "10" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "mRNA Splicing - Major Pathway" "" "1" "0" "0.973" "0.960" "0.966" "0.920" "0.965" "0.886" "0.928" "0.923" "0.746" "1789.1" "1740.5" "1716.7" "1728.4" "1646.7" "1727.0" "1584.9" "1660.5" "1651.3" "1334.3" "" "" "" "" "" "" "" "" "" "" "1586.5" "1441.8" "1497.9" "1292.6" "1373.1" "1586.4" "1339.5" "1372.5" "1514.5" "1334.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "64.987" "27" "9" "20" "9" "419" "46.3" "6.95" "72.35" "9" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Tyrosine catabolism" "Amino acid metabolism" "2" "0" "1.002" "0.994" "1.055" "1.037" "1.050" "1.054" "1.054" "0.937" "0.437" "1789.1" "1792.5" "1778.0" "1887.1" "1855.9" "1878.4" "1885.0" "1885.5" "1677.1" "781.3" "" "" "" "" "" "" "" "" "" "" "1586.6" "1484.8" "1551.4" "1411.3" "1547.6" "1725.5" "1593.1" "1558.5" "1538.1" "781.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "64.903" "12" "12" "20" "11" "1037" "111.0" "5.03" "68.24" "12" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "29" "0" "1.126" "0.952" "1.213" "1.112" "1.036" "1.188" "1.139" "1.060" "0.839" "1019.9" "1148.7" "971.1" "1237.5" "1134.5" "1057.0" "1211.9" "1161.6" "1081.3" "856.0" "" "" "" "" "" "" "" "" "" "" "904.4" "951.5" "847.3" "925.5" "946.0" "971.0" "1024.3" "960.1" "991.7" "856.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "64.627" "29" "7" "21" "7" "268" "28.3" "5.20" "77.61" "7" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion" "4" "0" "1.005" "1.051" "1.045" "1.082" "0.980" "1.091" "1.031" "1.064" "0.643" "1998.8" "2008.2" "2101.6" "2088.6" "2162.0" "1958.4" "2180.3" "2061.8" "2126.8" "1285.4" "" "" "" "" "" "" "" "" "" "" "1772.5" "1663.5" "1833.8" "1562.0" "1802.8" "1799.0" "1842.7" "1704.2" "1950.6" "1285.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246938043361698856" "False" "High" "IsMasterProtein" "O94842" "TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1" "0.000" "False" "64.601" "18" "10" "17" "8" "621" "66.2" "5.06" "71.71" "10" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "9878" "ENSG00000092203" "TOX4" "B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842" "" "" "0" "2" "0.941" "0.953" "0.963" "0.955" "0.957" "0.876" "0.836" "0.879" "0.882" "2132.4" "2005.6" "2033.1" "2053.3" "2036.0" "2041.7" "1868.9" "1781.7" "1874.0" "1881.8" "" "" "" "" "" "" "" "" "" "" "1891.0" "1661.4" "1774.0" "1535.6" "1697.8" "1875.5" "1579.5" "1472.7" "1718.7" "1881.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "64.547" "34" "11" "14" "9" "372" "42.8" "8.79" "54.52" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "20" "0" "1.000" "0.970" "1.124" "1.031" "1.050" "1.091" "1.039" "1.011" "1.170" "1135.9" "1135.6" "1101.4" "1276.8" "1171.4" "1192.3" "1239.0" "1180.1" "1148.2" "1328.7" "" "" "" "" "" "" "" "" "" "" "1007.3" "940.7" "961.0" "954.8" "976.8" "1095.3" "1047.1" "975.5" "1053.1" "1328.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "64.496" "27" "7" "18" "7" "340" "38.1" "5.41" "76.80" "7" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "0.956" "1.007" "0.924" "0.999" "1.071" "0.929" "1.023" "1.041" "0.499" "1641.0" "1568.2" "1652.5" "1515.5" "1640.0" "1756.7" "1525.3" "1678.8" "1707.9" "818.9" "" "" "" "" "" "" "" "" "" "" "1455.2" "1299.0" "1441.9" "1133.4" "1367.5" "1613.7" "1289.1" "1387.6" "1566.4" "818.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "64.495" "44" "7" "21" "5" "158" "17.3" "6.35" "79.62" "7" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "0.930" "0.970" "1.021" "0.926" "1.053" "1.013" "1.019" "1.018" "0.482" "1317.5" "1224.9" "1278.3" "1345.6" "1220.6" "1386.9" "1334.1" "1342.5" "1341.6" "635.7" "" "" "" "" "" "" "" "" "" "" "1168.4" "1014.6" "1115.4" "1006.3" "1017.8" "1274.0" "1127.6" "1109.7" "1230.4" "635.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "64.454" "26" "7" "16" "7" "315" "35.1" "6.70" "68.61" "7" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "1.010" "0.966" "1.031" "1.027" "1.070" "1.005" "0.994" "0.923" "0.614" "1729.0" "1745.8" "1669.6" "1782.7" "1775.1" "1850.3" "1737.9" "1719.2" "1596.0" "1061.3" "" "" "" "" "" "" "" "" "" "" "1533.2" "1446.1" "1456.8" "1333.2" "1480.2" "1699.7" "1468.8" "1421.0" "1463.8" "1061.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "64.412" "13" "17" "19" "17" "1369" "155.1" "8.09" "60.50" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.936" "0.907" "0.992" "0.914" "1.063" "1.115" "1.083" "1.110" "1.111" "1766.0" "1653.0" "1602.4" "1752.6" "1614.1" "1876.8" "1969.9" "1913.1" "1959.5" "1962.0" "" "" "" "" "" "" "" "" "" "" "1566.1" "1369.3" "1398.2" "1310.7" "1345.9" "1724.1" "1664.9" "1581.3" "1797.1" "1962.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3301543360737881129" "False" "High" "IsMasterProtein" "Q9Y281" "Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1" "0.000" "False" "64.095" "49" "9" "38" "3" "166" "18.7" "7.88" "119.72" "9" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1073" "ENSG00000165410" "CFL2" "G3V5P4; hsa:1073; Q9Y281" "" "Leptin signaling pathway; Microtubule cytoskeleton regulation; Regulation of actin cytoskeleton; G13 signaling pathway" "4" "0" "1.009" "0.877" "0.918" "0.894" "1.002" "0.850" "0.892" "0.812" "0.445" "1616.0" "1630.6" "1418.0" "1483.7" "1444.3" "1618.9" "1373.8" "1441.1" "1311.9" "719.0" "" "" "" "" "" "" "" "" "" "" "1433.0" "1350.7" "1237.3" "1109.6" "1204.3" "1487.1" "1161.1" "1191.2" "1203.2" "719.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "64.015" "27" "8" "26" "8" "326" "36.7" "5.92" "91.78" "8" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; tRNA processing in the nucleus; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "0.999" "0.978" "0.977" "1.026" "1.020" "0.928" "0.972" "0.932" "0.729" "2304.9" "2303.3" "2253.8" "2252.0" "2365.0" "2351.0" "2138.2" "2239.9" "2148.6" "1680.4" "" "" "" "" "" "" "" "" "" "" "2043.9" "1907.9" "1966.5" "1684.2" "1972.1" "2159.7" "1807.1" "1851.5" "1970.6" "1680.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.000" "False" "63.758" "13" "13" "13" "13" "1129" "125.9" "5.62" "49.83" "13" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "" "Mesodermal commitment pathway" "1" "0" "1.062" "0.948" "0.979" "0.922" "0.857" "0.909" "0.640" "0.897" "4.719" "1203.4" "1277.9" "1140.9" "1178.7" "1109.6" "1031.7" "1093.6" "769.6" "1079.4" "5679.3" "" "" "" "" "" "" "" "" "" "" "1067.2" "1058.5" "995.5" "881.5" "925.3" "947.7" "924.3" "636.1" "990.0" "5679.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6312780505627043912" "False" "High" "IsMasterProtein" "Q96E39" "RNA binding motif protein, X-linked-like-1 OS=Homo sapiens OX=9606 GN=RBMXL1 PE=1 SV=1" "0.000" "False" "63.757" "33" "15" "23" "2" "390" "42.1" "9.89" "77.87" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf08081" "494115" "ENSG00000213516" "RBMXL1" "hsa:494115; Q96E39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8171743116231663867" "False" "High" "IsMasterProtein" "A5YM69" "Rho guanine nucleotide exchange factor 35 OS=Homo sapiens OX=9606 GN=ARHGEF35 PE=1 SV=1" "0.000" "False" "63.757" "28" "9" "15" "2" "484" "53.3" "4.31" "62.62" "9" "" "" "" "Pf15441" "445328" "ENSG00000213214" "ARHGEF35" "A5YM69; hsa:445328; Q6ZUI2" "NRAGE signals death through JNK; G alpha (12/13) signalling events" "" "2" "0" "1.021" "1.039" "1.039" "0.863" "1.047" "0.968" "1.109" "1.231" "0.641" "46.9" "47.8" "48.7" "48.7" "40.4" "49.1" "45.4" "52.0" "57.7" "30.1" "" "" "" "" "" "" "" "" "" "" "41.6" "39.6" "42.5" "36.4" "33.7" "45.1" "38.3" "43.0" "52.9" "30.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7100532501288988865" "False" "High" "IsMasterProtein" "P55795" "Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1" "0.000" "False" "63.686" "20" "7" "21" "1" "449" "49.2" "6.30" "76.16" "7" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00076, Pf08080" "3188" "ENSG00000126945" "HNRNPH2" "A1L400; P55795; Q9HHA7" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "63.569" "47" "8" "33" "8" "168" "19.7" "8.43" "118.38" "8" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "1.039" "1.026" "1.083" "1.049" "1.087" "1.054" "1.073" "0.922" "0.524" "4112.3" "4274.7" "4219.0" "4452.8" "4314.6" "4468.7" "4335.7" "4414.1" "3793.5" "2153.6" "" "" "" "" "" "" "" "" "" "" "3646.7" "3540.9" "3681.2" "3330.1" "3597.8" "4105.0" "3664.4" "3648.6" "3479.2" "2153.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "63.511" "49" "10" "19" "10" "198" "22.4" "6.92" "71.49" "10" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "" "8" "0" "1.013" "0.992" "0.988" "0.996" "0.952" "1.014" "1.043" "0.948" "0.549" "3458.0" "3503.4" "3429.8" "3416.6" "3445.7" "3290.8" "3505.2" "3605.9" "3278.1" "1898.2" "" "" "" "" "" "" "" "" "" "" "3066.5" "2902.0" "2992.7" "2555.2" "2873.2" "3023.0" "2962.5" "2980.5" "3006.5" "1898.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "63.463" "16" "13" "13" "13" "944" "103.0" "6.07" "51.48" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "1.136" "0.896" "1.046" "1.016" "0.934" "1.045" "0.581" "0.899" "8.118" "492.3" "559.5" "441.0" "514.9" "500.5" "459.8" "514.7" "286.2" "442.9" "3996.7" "" "" "" "" "" "" "" "" "" "" "436.6" "463.4" "384.8" "385.1" "417.3" "422.4" "435.0" "236.5" "406.2" "3996.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "63.446" "32" "10" "17" "9" "393" "42.8" "8.50" "68.45" "10" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "TCA cycle (aka Krebs or citric acid cycle)" "3" "0" "1.029" "1.036" "1.041" "1.045" "1.003" "1.003" "1.040" "1.035" "0.599" "1372.2" "1412.3" "1422.1" "1427.8" "1433.3" "1377.0" "1375.8" "1427.0" "1420.2" "821.9" "" "" "" "" "" "" "" "" "" "" "1216.9" "1169.9" "1240.8" "1067.8" "1195.2" "1264.9" "1162.8" "1179.6" "1302.6" "821.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "63.431" "45" "9" "17" "9" "224" "24.4" "7.50" "62.89" "9" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "1.012" "0.911" "1.023" "0.900" "0.964" "0.966" "0.923" "0.921" "0.638" "1493.0" "1511.1" "1360.6" "1528.0" "1343.3" "1439.9" "1442.0" "1377.4" "1374.7" "953.1" "" "" "" "" "" "" "" "" "" "" "1324.0" "1251.7" "1187.2" "1142.7" "1120.1" "1322.7" "1218.7" "1138.5" "1260.8" "953.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062207759292809652" "False" "High" "IsMasterProtein" "Q13191" "E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens OX=9606 GN=CBLB PE=1 SV=2" "0.000" "False" "63.419" "15" "13" "20" "9" "982" "109.4" "7.88" "69.53" "13" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02262, Pf02761, Pf02762" "868" "ENSG00000114423" "CBLB" "A8K9S7; B7WNM4; Q13191; Q13192; Q13193; Q3LIC0; Q63Z43; Q8IVC5" "Antigen processing: Ubiquitination & Proteasome degradation" "Angiopoietin-like protein 8 regulatory pathway; Fibrin complement receptor 3 signaling pathway; EGF/EGFR signaling pathway; Measles virus infection; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor signaling pathway" "9" "0" "0.974" "0.948" "1.019" "0.951" "0.956" "0.875" "0.845" "0.882" "1.777" "758.9" "738.8" "719.6" "773.7" "721.9" "725.6" "663.7" "641.5" "669.2" "1348.7" "" "" "" "" "" "" "" "" "" "" "673.0" "612.0" "627.9" "578.6" "602.0" "666.5" "560.9" "530.3" "613.8" "1348.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "63.375" "24" "7" "13" "7" "391" "42.1" "9.00" "57.94" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "RUNX1 regulates transcription of genes involved in BCR signaling" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "4" "0" "1.059" "1.044" "0.968" "1.060" "0.965" "0.872" "0.849" "0.980" "1.130" "1080.5" "1144.7" "1128.4" "1046.2" "1145.3" "1042.6" "942.3" "917.7" "1059.1" "1220.5" "" "" "" "" "" "" "" "" "" "" "958.1" "948.2" "984.6" "782.4" "955.0" "957.7" "796.4" "758.5" "971.4" "1220.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "63.365" "29" "11" "15" "11" "399" "44.2" "5.10" "59.62" "11" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "10" "0" "1.059" "1.012" "1.098" "1.055" "1.089" "1.140" "1.150" "1.002" "0.482" "2263.3" "2396.5" "2290.1" "2484.1" "2388.7" "2464.3" "2580.3" "2602.5" "2267.1" "1091.6" "" "" "" "" "" "" "" "" "" "" "2007.0" "1985.1" "1998.2" "1857.8" "1991.9" "2263.7" "2180.7" "2151.2" "2079.2" "1091.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "63.354" "26" "9" "13" "9" "403" "43.8" "5.78" "51.21" "9" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "1.015" "1.025" "0.997" "1.011" "1.009" "0.949" "1.003" "1.011" "0.952" "1533.1" "1556.2" "1571.3" "1528.6" "1550.8" "1547.2" "1454.9" "1537.5" "1550.6" "1459.0" "" "" "" "" "" "" "" "" "" "" "1359.6" "1289.1" "1371.0" "1143.2" "1293.1" "1421.3" "1229.6" "1270.9" "1422.1" "1459.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.000" "False" "63.011" "29" "8" "14" "8" "266" "29.8" "6.84" "50.34" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "HATs acetylate histones" "" "1" "0" "0.992" "0.953" "0.929" "1.009" "1.054" "0.958" "1.011" "0.845" "0.660" "961.1" "953.7" "916.0" "892.5" "969.4" "1013.4" "920.7" "971.7" "812.6" "634.3" "" "" "" "" "" "" "" "" "" "" "852.3" "790.0" "799.2" "667.5" "808.4" "930.9" "778.2" "803.2" "745.2" "634.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "62.983" "33" "14" "17" "14" "403" "46.1" "10.18" "54.47" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.957" "0.906" "0.913" "0.871" "0.900" "0.812" "0.825" "0.806" "1.069" "1781.7" "1704.4" "1614.7" "1626.3" "1552.4" "1603.9" "1446.8" "1470.1" "1435.8" "1904.6" "" "" "" "" "" "" "" "" "" "" "1580.0" "1411.8" "1408.9" "1216.3" "1294.5" "1473.3" "1222.8" "1215.1" "1316.8" "1904.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "62.971" "19" "6" "13" "6" "350" "39.4" "5.53" "53.75" "6" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "10" "0" "1.023" "0.991" "0.971" "1.043" "1.020" "1.053" "1.039" "0.993" "0.553" "1908.5" "1953.1" "1891.0" "1853.6" "1990.2" "1947.3" "2008.9" "1982.4" "1894.7" "1054.9" "" "" "" "" "" "" "" "" "" "" "1692.4" "1617.8" "1650.0" "1386.3" "1659.6" "1788.8" "1697.9" "1638.6" "1737.7" "1054.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.000" "False" "62.936" "32" "9" "15" "9" "306" "33.9" "8.59" "57.55" "9" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "1.053" "1.085" "0.867" "0.917" "1.035" "0.671" "0.757" "0.808" "0.955" "2574.9" "2710.2" "2792.6" "2232.2" "2360.6" "2663.8" "1728.8" "1950.4" "2080.5" "2459.0" "" "" "" "" "" "" "" "" "" "" "2283.4" "2245.0" "2436.7" "1669.4" "1968.4" "2447.0" "1461.1" "1612.1" "1908.1" "2459.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "62.884" "35" "11" "16" "11" "352" "39.6" "5.19" "57.96" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "RND3 GTPase cycle; Striated Muscle Contraction; RHOBTB2 GTPase cycle" "VEGFA-VEGFR2 signaling" "4" "0" "0.985" "0.872" "0.944" "0.923" "0.900" "0.890" "0.820" "0.976" "2.971" "1170.6" "1152.4" "1020.4" "1105.3" "1080.5" "1053.2" "1042.1" "959.3" "1143.0" "3477.8" "" "" "" "" "" "" "" "" "" "" "1038.0" "954.6" "890.3" "826.6" "901.0" "967.4" "880.7" "792.9" "1048.3" "3477.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "62.881" "24" "14" "21" "14" "553" "60.1" "6.64" "72.05" "14" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "0.973" "0.983" "0.949" "0.936" "0.879" "0.914" "0.857" "0.926" "1.085" "790.7" "769.3" "777.0" "750.6" "739.7" "694.7" "723.0" "677.2" "731.9" "857.8" "" "" "" "" "" "" "" "" "" "" "701.1" "637.2" "677.9" "561.3" "616.8" "638.2" "611.0" "559.8" "671.3" "857.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.000" "False" "62.814" "44" "9" "17" "9" "268" "29.0" "6.43" "61.23" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "1.023" "0.985" "1.007" "1.110" "1.032" "1.129" "1.097" "1.040" "0.494" "1980.1" "2025.2" "1950.8" "1994.8" "2197.9" "2043.4" "2236.4" "2172.8" "2059.4" "978.3" "" "" "" "" "" "" "" "" "" "" "1755.9" "1677.6" "1702.2" "1491.8" "1832.8" "1877.1" "1890.1" "1795.9" "1888.8" "978.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621085061721332365" "False" "High" "IsMasterProtein" "P48382" "DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1" "0.000" "False" "62.761" "19" "11" "16" "11" "616" "65.3" "9.29" "52.63" "11" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf14621, Pf18326" "5993" "ENSG00000143390" "RFX5" "B7Z848; D3DV19; E9PFU4; hsa:5993; P48382; Q5VWC3" "" "Prion disease pathway; IL-18 signaling pathway" "2" "0" "1.037" "0.981" "1.007" "1.000" "0.958" "1.008" "0.943" "0.992" "1.257" "1067.7" "1106.8" "1047.3" "1075.3" "1067.4" "1023.0" "1076.5" "1006.8" "1059.7" "1342.1" "" "" "" "" "" "" "" "" "" "" "946.8" "916.8" "913.8" "804.2" "890.1" "939.7" "909.9" "832.2" "971.9" "1342.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4097484419734302186" "False" "High" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "0.000" "False" "62.760" "22" "14" "16" "14" "628" "68.7" "5.69" "56.81" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf21198, Pf21257" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Deactivation of the beta-catenin transactivating complex; Formation of the beta-catenin:TCF transactivating complex; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Kleefstra syndrome" "7" "0" "0.955" "0.867" "0.899" "0.820" "0.823" "0.755" "0.783" "0.871" "1.111" "1619.1" "1546.2" "1404.2" "1456.3" "1328.3" "1333.1" "1223.2" "1267.2" "1410.3" "1799.6" "" "" "" "" "" "" "" "" "" "" "1435.8" "1280.8" "1225.2" "1089.1" "1107.6" "1224.6" "1033.8" "1047.4" "1293.4" "1799.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "62.706" "31" "8" "15" "8" "374" "41.7" "4.92" "55.59" "8" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "0.957" "0.957" "0.973" "1.017" "0.955" "0.963" "0.971" "0.966" "0.547" "1138.6" "1089.2" "1089.1" "1108.1" "1158.1" "1087.1" "1096.4" "1105.9" "1100.0" "623.3" "" "" "" "" "" "" "" "" "" "" "1009.7" "902.3" "950.3" "828.7" "965.7" "998.6" "926.6" "914.1" "1008.9" "623.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "62.681" "37" "9" "12" "9" "308" "34.5" "5.12" "52.39" "9" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.208" "1.271" "1.065" "1.274" "1.093" "1.070" "1.058" "1.182" "1.103" "611.2" "738.5" "776.9" "651.0" "778.7" "667.8" "654.1" "646.4" "722.7" "674.3" "" "" "" "" "" "" "" "" "" "" "542.0" "611.7" "677.9" "486.9" "649.3" "613.5" "552.8" "534.3" "662.8" "674.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "62.664" "28" "11" "20" "10" "346" "39.2" "5.71" "77.08" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "Post-chaperonin tubulin folding pathway" "" "1" "0" "0.937" "0.835" "0.933" "0.844" "0.804" "0.874" "0.845" "0.844" "0.773" "1815.5" "1700.6" "1515.4" "1693.8" "1531.5" "1460.4" "1587.0" "1534.3" "1533.0" "1403.6" "" "" "" "" "" "" "" "" "" "" "1609.9" "1408.7" "1322.2" "1266.7" "1277.1" "1341.6" "1341.3" "1268.2" "1406.0" "1403.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.000" "False" "62.607" "17" "2" "17" "2" "173" "18.9" "4.88" "80.02" "2" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "Glycine degradation" "" "2" "0" "1.038" "1.023" "1.001" "1.027" "1.023" "1.008" "1.074" "1.097" "0.401" "1661.1" "1725.0" "1699.4" "1662.7" "1706.1" "1698.9" "1675.2" "1784.0" "1821.8" "665.5" "" "" "" "" "" "" "" "" "" "" "1473.1" "1428.9" "1482.8" "1243.5" "1422.6" "1560.7" "1415.8" "1474.6" "1670.8" "665.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "62.569" "6" "11" "15" "11" "2357" "251.7" "5.80" "58.72" "11" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "COPII-mediated vesicle transport" "" "1" "0" "0.961" "0.962" "0.876" "0.879" "0.860" "0.895" "0.930" "1.043" "1.003" "1466.3" "1409.4" "1411.1" "1284.8" "1289.4" "1260.5" "1312.6" "1363.4" "1529.2" "1470.6" "" "" "" "" "" "" "" "" "" "" "1300.3" "1167.4" "1231.2" "960.8" "1075.2" "1157.9" "1109.4" "1127.0" "1402.5" "1470.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "62.492" "24" "9" "11" "9" "442" "49.7" "5.14" "48.21" "9" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "" "NF1 copy number variation syndrome" "1" "0" "1.069" "0.924" "1.003" "0.892" "0.831" "0.946" "0.537" "0.908" "6.734" "982.4" "1050.4" "907.5" "985.4" "876.8" "816.5" "929.0" "527.9" "892.2" "6615.1" "" "" "" "" "" "" "" "" "" "" "871.2" "870.1" "791.9" "737.0" "731.1" "750.0" "785.1" "436.4" "818.3" "6615.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6837951581036984725" "False" "High" "IsMasterProtein" "P33241" "Lymphocyte-specific protein 1 OS=Homo sapiens OX=9606 GN=LSP1 PE=1 SV=1" "0.000" "False" "62.434" "42" "10" "14" "10" "339" "37.2" "4.74" "56.07" "10" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton" "cytoskeletal activity" "Pf02029" "4046" "ENSG00000130592; ENSG00000288199" "LSP1" "B3KPP1; B3KRR6; E9PBV6; E9PFP3; hsa:4046; P33241; Q16096; Q53H48; Q6FHM3; Q9BUY8" "" "" "0" "0" "0.864" "0.916" "0.949" "0.938" "0.973" "0.887" "0.980" "0.965" "0.491" "1108.3" "958.1" "1015.2" "1052.1" "1039.4" "1078.7" "983.5" "1086.5" "1070.0" "543.8" "" "" "" "" "" "" "" "" "" "" "982.8" "793.7" "885.8" "786.8" "866.7" "990.9" "831.2" "898.1" "981.3" "543.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "62.339" "19" "12" "15" "12" "707" "78.7" "9.01" "55.97" "12" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "1.024" "0.985" "1.081" "1.084" "1.009" "1.073" "1.086" "0.985" "0.511" "1085.8" "1111.4" "1069.7" "1173.9" "1177.3" "1095.4" "1165.6" "1179.6" "1069.2" "555.0" "" "" "" "" "" "" "" "" "" "" "962.9" "920.6" "933.3" "877.9" "981.7" "1006.2" "985.1" "975.0" "980.6" "555.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580559568770530829" "False" "High" "IsMasterProtein" "Q14135" "Transcription cofactor vestigial-like protein 4 OS=Homo sapiens OX=9606 GN=VGLL4 PE=1 SV=4" "0.000" "False" "62.124" "46" "9" "14" "9" "290" "30.9" "8.22" "57.52" "9" "other biological processes" "nucleus" "other molecular function" "Pf15245" "9686" "ENSG00000144560" "VGLL4" "B4DTS7; hsa:9686; J3KN68; Q14135; Q7L5V0; Q9BQ78" "" "Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "2" "0" "0.945" "0.960" "1.019" "0.992" "0.975" "0.863" "0.913" "0.899" "0.506" "1292.4" "1221.1" "1241.1" "1317.4" "1282.4" "1260.2" "1114.7" "1179.8" "1162.0" "653.8" "" "" "" "" "" "" "" "" "" "" "1146.1" "1011.5" "1082.9" "985.2" "1069.4" "1157.6" "942.1" "975.2" "1065.7" "653.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "62.086" "20" "5" "11" "3" "327" "35.1" "5.27" "49.84" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "ADORA2B mediated anti-inflammatory cytokines production; Transcriptional regulation of granulopoiesis; FCGR3A-mediated IL10 synthesis; HCMV Early Events; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "85" "0" "0.889" "0.919" "0.891" "0.885" "0.876" "0.936" "0.931" "0.954" "0.465" "485.1" "431.3" "446.0" "432.2" "429.2" "425.0" "453.8" "451.4" "462.8" "225.7" "" "" "" "" "" "" "" "" "" "" "430.1" "357.2" "389.1" "323.3" "357.9" "390.4" "383.5" "373.1" "424.5" "225.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "62.058" "45" "7" "25" "5" "117" "13.7" "8.10" "78.84" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "TBC/RABGAPs; Macroautophagy" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "5" "2" "0.993" "1.064" "0.934" "0.972" "1.055" "0.998" "1.066" "1.043" "0.730" "2164.8" "2150.6" "2302.3" "2021.3" "2104.0" "2283.8" "2161.4" "2307.9" "2258.3" "1580.1" "" "" "" "" "" "" "" "" "" "" "1919.7" "1781.5" "2008.8" "1511.6" "1754.5" "2097.9" "1826.8" "1907.6" "2071.2" "1580.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "62.051" "19" "17" "17" "17" "986" "111.5" "7.27" "53.36" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "Pathogenic Escherichia coli infection" "5" "0" "1.214" "0.986" "1.200" "1.235" "0.993" "1.013" "0.612" "1.074" "7.019" "757.4" "919.5" "747.1" "908.6" "935.7" "752.2" "767.3" "463.9" "813.4" "5316.4" "" "" "" "" "" "" "" "" "" "" "671.7" "761.7" "651.9" "679.5" "780.2" "690.9" "648.5" "383.4" "746.0" "5316.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7964397888877464485" "False" "High" "IsMasterProtein" "P50897" "Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1" "0.000" "False" "62.005" "32" "7" "14" "7" "306" "34.2" "6.52" "62.88" "7" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02089" "5538" "ENSG00000131238" "PPT1" "B4DY24; hsa:5538; P50897; Q6FGQ4" "Fatty acyl-CoA biosynthesis" "" "1" "0" "0.993" "1.076" "0.933" "1.015" "1.138" "1.018" "1.114" "1.156" "0.794" "1231.8" "1223.1" "1325.6" "1149.7" "1249.8" "1401.3" "1254.2" "1372.8" "1423.8" "978.1" "" "" "" "" "" "" "" "" "" "" "1092.3" "1013.2" "1156.7" "859.9" "1042.1" "1287.3" "1060.0" "1134.7" "1305.8" "978.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "61.999" "14" "11" "17" "10" "841" "92.8" "10.11" "64.55" "11" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "1" "1.034" "1.006" "0.940" "0.925" "0.880" "0.948" "0.940" "0.978" "1.040" "1050.2" "1085.5" "1056.3" "987.0" "971.5" "924.6" "996.1" "986.9" "1026.7" "1091.9" "" "" "" "" "" "" "" "" "" "" "931.3" "899.2" "921.6" "738.2" "810.1" "849.3" "841.8" "815.8" "941.6" "1091.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "61.987" "50" "11" "14" "10" "201" "23.4" "6.64" "53.10" "11" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Purine catabolism; Pyrimidine catabolism" "Pyrimidine metabolism" "3" "1" "0.966" "0.904" "1.025" "1.022" "0.997" "0.999" "0.991" "1.033" "0.497" "1384.9" "1338.1" "1252.4" "1419.2" "1414.9" "1381.1" "1384.0" "1372.7" "1430.6" "688.0" "" "" "" "" "" "" "" "" "" "" "1228.1" "1108.4" "1092.8" "1061.4" "1179.8" "1268.7" "1169.7" "1134.7" "1312.1" "688.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "61.920" "46" "5" "29" "5" "104" "12.3" "5.92" "100.96" "5" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "0.935" "0.955" "0.886" "0.922" "0.986" "0.983" "1.056" "1.080" "0.421" "5635.7" "5268.6" "5384.3" "4992.6" "5196.6" "5557.9" "5539.8" "5954.0" "6085.7" "2372.7" "" "" "" "" "" "" "" "" "" "" "4997.6" "4364.2" "4698.1" "3733.8" "4333.2" "5105.5" "4682.0" "4921.4" "5581.4" "2372.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "61.910" "12" "13" "16" "9" "1066" "114.1" "7.08" "50.78" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Neddylation" "Male infertility" "2" "2" "1.030" "1.025" "0.941" "0.998" "1.010" "0.987" "0.965" "0.996" "1.332" "1671.4" "1722.0" "1713.0" "1573.1" "1667.6" "1687.4" "1649.6" "1612.1" "1664.0" "2226.7" "" "" "" "" "" "" "" "" "" "" "1482.2" "1426.4" "1494.6" "1176.4" "1390.6" "1550.1" "1394.2" "1332.5" "1526.1" "2226.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "61.823" "18" "14" "17" "14" "822" "91.3" "6.80" "62.55" "14" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "1.042" "1.005" "1.063" "1.055" "0.980" "1.114" "0.953" "0.974" "3.111" "1409.4" "1467.9" "1415.8" "1497.7" "1487.4" "1381.0" "1569.9" "1342.6" "1372.4" "4384.6" "" "" "" "" "" "" "" "" "" "" "1249.8" "1215.9" "1235.4" "1120.0" "1240.3" "1268.6" "1326.9" "1109.7" "1258.7" "4384.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1141422113329583141" "False" "High" "IsMasterProtein" "Q04446" "1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3" "0.000" "False" "61.789" "23" "15" "16" "15" "702" "80.4" "6.32" "58.75" "15" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00128, Pf02806, Pf02922" "2632" "ENSG00000114480" "GBE1" "B3KWV3; hsa:2632; Q04446; Q96EN0" "Glycogen synthesis; Glycogen storage disease type IV (GBE1)" "Glycogen synthesis and degradation; Disorders of galactose metabolism" "4" "0" "1.014" "0.986" "1.036" "0.974" "0.946" "1.011" "0.463" "1.000" "13.045" "738.6" "749.0" "728.4" "765.3" "719.6" "699.0" "746.3" "342.2" "738.7" "9634.5" "" "" "" "" "" "" "" "" "" "" "654.9" "620.5" "635.5" "572.4" "600.0" "642.1" "630.8" "282.8" "677.5" "9634.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "High" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.000" "False" "61.691" "12" "8" "13" "8" "750" "83.1" "6.93" "50.28" "8" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "Vitamin B12 metabolism; Amino acid metabolism" "6" "0" "1.108" "1.048" "1.070" "1.057" "1.106" "1.063" "1.094" "1.060" "0.794" "1298.8" "1439.5" "1361.0" "1389.4" "1372.6" "1436.7" "1381.0" "1420.9" "1377.3" "1030.9" "" "" "" "" "" "" "" "" "" "" "1151.7" "1192.5" "1187.5" "1039.1" "1144.6" "1319.8" "1167.2" "1174.5" "1263.1" "1030.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.000" "False" "61.637" "18" "5" "15" "5" "460" "50.5" "8.25" "67.09" "5" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "B cell receptor signaling pathway" "3" "0" "0.930" "0.936" "0.927" "0.958" "0.958" "0.850" "0.871" "0.891" "0.475" "752.7" "700.2" "704.5" "698.0" "720.7" "721.1" "639.6" "655.6" "670.5" "357.7" "" "" "" "" "" "" "" "" "" "" "667.4" "580.0" "614.7" "522.0" "601.0" "662.4" "540.6" "541.9" "614.9" "357.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3247337186477247949" "False" "High" "IsMasterProtein" "Q9UQR1" "Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2" "0.000" "False" "61.635" "16" "10" "21" "10" "794" "88.9" "6.48" "55.75" "10" "stress response;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7707" "ENSG00000163848" "ZNF148" "D3DN27; O00389; O43591; Q58EY5; Q6PJ98; Q9UQR1" "" "" "0" "0" "1.014" "0.914" "0.984" "0.939" "0.848" "0.907" "0.949" "0.941" "0.992" "581.8" "590.1" "531.9" "572.7" "546.5" "493.1" "527.5" "552.3" "547.6" "577.1" "" "" "" "" "" "" "" "" "" "" "516.0" "488.8" "464.2" "428.3" "455.7" "453.0" "445.8" "456.5" "502.2" "577.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "61.616" "48" "7" "19" "7" "182" "20.6" "4.92" "62.83" "7" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "0.982" "0.983" "0.935" "0.897" "0.982" "1.016" "1.010" "0.985" "0.543" "1170.6" "1149.0" "1150.1" "1094.0" "1049.9" "1149.8" "1189.1" "1181.7" "1152.9" "635.5" "" "" "" "" "" "" "" "" "" "" "1038.0" "951.8" "1003.5" "818.2" "875.5" "1056.2" "1005.0" "976.8" "1057.4" "635.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "61.611" "21" "9" "20" "4" "483" "50.9" "8.75" "82.09" "9" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "18" "0" "1.072" "1.028" "1.113" "1.138" "1.091" "1.080" "1.063" "1.059" "0.768" "879.6" "943.2" "904.0" "979.1" "1001.1" "959.3" "950.4" "934.9" "931.6" "675.2" "" "" "" "" "" "" "" "" "" "" "780.0" "781.3" "788.8" "732.2" "834.8" "881.2" "803.2" "772.7" "854.4" "675.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "High" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.000" "False" "61.605" "21" "7" "17" "7" "392" "44.3" "8.65" "74.91" "7" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Branched-chain amino acid catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "3" "0" "1.025" "0.971" "1.112" "1.072" "1.074" "1.111" "1.013" "0.785" "0.414" "1528.8" "1567.7" "1485.1" "1700.5" "1639.2" "1642.6" "1698.1" "1548.4" "1199.7" "633.2" "" "" "" "" "" "" "" "" "" "" "1355.7" "1298.6" "1295.8" "1271.7" "1366.9" "1508.9" "1435.2" "1279.8" "1100.3" "633.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "61.569" "11" "14" "15" "14" "1508" "168.5" "6.62" "53.50" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "1.015" "0.961" "0.990" "0.992" "0.926" "0.993" "0.818" "0.878" "2.804" "576.0" "584.8" "553.8" "570.2" "571.6" "533.5" "571.8" "471.5" "505.6" "1615.4" "" "" "" "" "" "" "" "" "" "" "510.8" "484.4" "483.2" "426.4" "476.6" "490.1" "483.3" "389.7" "463.7" "1615.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828949100496623215" "False" "High" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "0.000" "False" "61.569" "34" "12" "15" "12" "425" "47.8" "5.68" "60.57" "12" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "7" "0" "0.966" "0.965" "0.998" "0.991" "1.034" "0.926" "0.869" "0.985" "1.525" "1645.7" "1589.5" "1588.5" "1641.9" "1631.6" "1701.5" "1523.3" "1430.7" "1621.4" "2509.8" "" "" "" "" "" "" "" "" "" "" "1459.4" "1316.7" "1386.0" "1227.9" "1360.5" "1563.0" "1287.4" "1182.5" "1487.1" "2509.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "61.558" "33" "8" "23" "6" "225" "25.5" "9.72" "85.74" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA Splicing - Major Pathway" "mRNA processing; Ciliary landscape" "3" "0" "0.914" "0.971" "0.944" "0.933" "0.951" "0.923" "0.934" "0.908" "0.570" "2046.4" "1870.2" "1986.5" "1930.9" "1909.6" "1946.3" "1888.2" "1912.2" "1857.8" "1166.2" "" "" "" "" "" "" "" "" "" "" "1814.7" "1549.2" "1733.3" "1444.1" "1592.4" "1787.9" "1595.8" "1580.6" "1703.9" "1166.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "61.543" "31" "10" "16" "10" "386" "43.2" "7.17" "62.01" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "0.958" "1.048" "0.988" "0.935" "0.948" "1.155" "1.040" "1.056" "1.392" "2221.8" "2127.6" "2329.0" "2194.4" "2076.5" "2106.8" "2566.4" "2311.3" "2346.7" "3093.8" "" "" "" "" "" "" "" "" "" "" "1970.2" "1762.4" "2032.1" "1641.1" "1731.5" "1935.3" "2169.0" "1910.4" "2152.2" "3093.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "61.542" "36" "10" "15" "6" "355" "40.4" "5.54" "56.42" "10" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "22" "2" "1.103" "1.057" "0.961" "1.107" "1.066" "1.097" "1.047" "1.290" "1.607" "782.3" "863.1" "827.2" "751.6" "866.2" "833.9" "857.9" "819.3" "1009.2" "1257.1" "" "" "" "" "" "" "" "" "" "" "693.7" "714.9" "721.8" "562.1" "722.3" "766.1" "725.1" "677.2" "925.6" "1257.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.000" "False" "61.435" "24" "8" "20" "6" "284" "33.3" "9.31" "68.97" "8" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "2" "1.015" "1.103" "0.919" "1.104" "1.161" "0.932" "1.038" "1.048" "0.428" "3398.4" "3448.9" "3748.7" "3124.3" "3750.6" "3945.8" "3165.7" "3528.7" "3562.6" "1453.8" "" "" "" "" "" "" "" "" "" "" "3013.6" "2856.9" "3271.0" "2336.6" "3127.5" "3624.6" "2675.5" "2916.7" "3267.4" "1453.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "High" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.000" "False" "61.394" "31" "6" "16" "6" "195" "21.6" "6.34" "54.45" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "13" "0" "0.998" "1.013" "0.973" "1.044" "1.054" "1.000" "0.973" "0.936" "0.664" "1529.1" "1525.7" "1548.5" "1488.3" "1596.7" "1611.7" "1529.4" "1487.7" "1431.3" "1015.8" "" "" "" "" "" "" "" "" "" "" "1355.9" "1263.8" "1351.1" "1113.1" "1331.5" "1480.5" "1292.6" "1229.7" "1312.7" "1015.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "61.370" "35" "10" "17" "10" "285" "33.3" "5.86" "59.53" "10" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "0.969" "0.938" "0.941" "0.908" "0.966" "0.909" "0.934" "0.960" "0.456" "2448.7" "2372.0" "2298.0" "2303.1" "2223.9" "2365.2" "2226.8" "2287.1" "2350.7" "1117.2" "" "" "" "" "" "" "" "" "" "" "2171.5" "1964.9" "2005.1" "1722.4" "1854.4" "2172.7" "1882.0" "1890.5" "2155.9" "1117.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "61.341" "43" "7" "18" "7" "222" "25.4" "10.02" "69.39" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.064" "0.991" "1.002" "1.017" "1.051" "0.970" "1.021" "0.954" "0.827" "1201.3" "1278.8" "1190.5" "1203.1" "1221.8" "1263.0" "1165.7" "1226.8" "1146.4" "993.8" "" "" "" "" "" "" "" "" "" "" "1065.3" "1059.3" "1038.7" "899.8" "1018.9" "1160.2" "985.2" "1014.0" "1051.4" "993.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3045251361027418727" "False" "High" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "0.000" "False" "61.323" "24" "9" "10" "8" "492" "54.1" "6.38" "43.20" "9" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "14" "0" "0.965" "1.025" "1.037" "0.970" "0.924" "1.146" "1.107" "1.105" "1.589" "644.6" "621.9" "660.8" "668.7" "624.9" "595.4" "738.8" "713.6" "712.1" "1024.2" "" "" "" "" "" "" "" "" "" "" "571.6" "515.1" "576.5" "500.1" "521.1" "547.0" "624.4" "589.9" "653.1" "1024.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7453155325725910333" "False" "High" "IsMasterProtein" "Q9Y2K2" "Serine/threonine-protein kinase SIK3 OS=Homo sapiens OX=9606 GN=SIK3 PE=1 SV=4" "0.000" "False" "61.240" "12" "14" "18" "14" "1321" "144.8" "6.79" "56.61" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069" "23387" "ENSG00000160584" "SIK3" "A1A5A8; H0Y494; hsa:23387; J3KPC8; Q59FY2; Q5M9N1; Q6P3R6; Q8IYM8; Q9HA50; Q9Y2K2" "" "" "0" "0" "1.048" "0.936" "1.072" "1.139" "1.123" "1.285" "1.171" "1.144" "1.108" "1000.8" "1048.6" "936.3" "1072.5" "1139.7" "1124.3" "1285.6" "1171.4" "1144.8" "1108.4" "" "" "" "" "" "" "" "" "" "" "887.5" "868.6" "816.9" "802.1" "950.3" "1032.8" "1086.5" "968.3" "1050.0" "1108.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "61.214" "6" "14" "15" "8" "2442" "265.2" "8.53" "58.08" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Heme signaling; NFE2L2 regulating anti-oxidant/detoxification enzymes; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; NPAS4 regulates expression of target genes; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Formation of the beta-catenin:TCF transactivating complex; SUMOylation of transcription cofactors; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Pre-NOTCH Transcription and Translation; Activation of gene expression by SREBF (SREBP); HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "74" "4" "0.910" "0.948" "0.908" "0.878" "0.896" "0.835" "0.852" "0.874" "1.032" "1828.0" "1662.9" "1733.1" "1660.7" "1605.8" "1638.7" "1526.1" "1556.7" "1597.5" "1886.3" "" "" "" "" "" "" "" "" "" "" "1621.0" "1377.4" "1512.2" "1242.0" "1339.0" "1505.3" "1289.8" "1286.7" "1465.1" "1886.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "High" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.000" "False" "61.209" "23" "12" "17" "11" "529" "60.7" "5.16" "59.36" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "7" "0" "1.015" "1.007" "1.106" "1.046" "1.081" "1.117" "1.018" "0.984" "0.672" "1085.8" "1102.4" "1093.1" "1200.9" "1135.4" "1174.0" "1213.2" "1105.7" "1068.3" "730.2" "" "" "" "" "" "" "" "" "" "" "962.9" "913.2" "953.8" "898.1" "946.8" "1078.4" "1025.4" "913.9" "979.8" "730.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6149624510723031081" "False" "High" "IsMasterProtein" "P30043" "Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3" "0.000" "False" "61.099" "43" "6" "12" "6" "206" "22.1" "7.65" "45.68" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13460" "645" "ENSG00000090013" "BLVRB" "A6NKD8; B2R5C6; hsa:645; P30043; P32078; P53005; Q32LZ2" "Cytoprotection by HMOX1; Heme degradation" "Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway" "5" "0" "0.942" "0.880" "1.083" "0.971" "0.983" "1.138" "1.044" "1.048" "1.579" "537.4" "506.2" "472.9" "582.0" "521.7" "528.0" "611.5" "561.0" "563.4" "848.7" "" "" "" "" "" "" "" "" "" "" "476.6" "419.3" "412.6" "435.3" "435.0" "485.1" "516.8" "463.7" "516.7" "848.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "61.084" "47" "5" "9" "5" "158" "18.0" "6.74" "42.32" "5" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.949" "0.872" "1.024" "0.978" "0.922" "1.015" "0.891" "0.940" "3.095" "494.0" "469.0" "431.0" "505.9" "483.2" "455.7" "501.3" "440.1" "464.4" "1528.9" "" "" "" "" "" "" "" "" "" "" "438.1" "388.5" "376.1" "378.4" "403.0" "418.6" "423.7" "363.7" "425.9" "1528.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "61.051" "20" "10" "12" "10" "677" "73.3" "4.84" "54.25" "10" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "1.019" "0.980" "1.069" "0.965" "0.967" "1.047" "0.799" "0.993" "5.233" "920.4" "937.5" "902.4" "983.5" "888.2" "890.2" "963.7" "735.7" "913.7" "4816.5" "" "" "" "" "" "" "" "" "" "" "816.2" "776.5" "787.4" "735.5" "740.7" "817.8" "814.5" "608.1" "838.0" "4816.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "60.975" "51" "10" "13" "9" "191" "22.2" "5.86" "50.54" "10" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6; Factors involved in megakaryocyte development and platelet production" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "5" "1" "0.981" "0.970" "0.914" "0.975" "0.998" "0.981" "0.915" "0.965" "1.352" "1231.2" "1207.9" "1194.7" "1125.1" "1200.9" "1229.2" "1207.2" "1126.1" "1187.6" "1664.2" "" "" "" "" "" "" "" "" "" "" "1091.8" "1000.6" "1042.4" "841.4" "1001.4" "1129.1" "1020.3" "930.8" "1089.2" "1664.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-221730190353322517" "False" "High" "IsMasterProtein" "Q9UL63" "Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2" "0.000" "False" "60.972" "15" "8" "12" "8" "735" "84.7" "6.34" "45.77" "8" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf06588, Pf13415" "4289" "ENSG00000128585" "MKLN1" "A4D1M8; A6NG43; hsa:4289; Q9NSK4; Q9NUS8; Q9UL63" "" "Ciliary landscape" "1" "0" "1.102" "1.062" "1.158" "1.129" "1.121" "1.087" "1.054" "0.998" "1.093" "690.9" "761.3" "733.6" "799.8" "780.2" "774.2" "751.0" "728.3" "689.5" "754.9" "" "" "" "" "" "" "" "" "" "" "612.7" "630.6" "640.1" "598.2" "650.6" "711.2" "634.7" "602.0" "632.3" "754.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "60.929" "17" "7" "9" "7" "493" "57.8" "5.63" "41.19" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Antigen processing: Ubiquitination & Proteasome degradation" "Modulators of TCR signaling and T cell activation" "2" "0" "1.008" "0.989" "1.029" "1.005" "1.049" "0.943" "0.932" "0.969" "1.247" "718.2" "724.1" "710.1" "738.7" "722.0" "753.7" "677.4" "669.1" "696.0" "895.6" "" "" "" "" "" "" "" "" "" "" "636.9" "599.8" "619.6" "552.5" "602.0" "692.4" "572.5" "553.0" "638.3" "895.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2659505507426523226" "False" "High" "IsMasterProtein" "P0CAP2" "DNA-directed RNA polymerase II subunit GRINL1A OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1" "0.000" "False" "60.920" "32" "10" "11" "10" "368" "41.7" "6.39" "43.38" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15328" "81488" "ENSG00000255529" "POLR2M" "hsa:81488; P0CAP2; Q6EER8; Q6EES2; Q6EEV3; Q6EF00; Q6EF01; Q6EF02; Q6EF46; Q6EFN8; Q6EM48; Q6K046; Q6K050; Q6K051; Q6ZQZ3; Q8NC58; Q8NCF3; Q96DI5; Q96JB7; Q96NF5; Q9Y3V6" "" "" "0" "0" "0.970" "0.963" "0.977" "0.962" "0.987" "0.892" "0.894" "0.897" "0.736" "1426.3" "1383.9" "1373.6" "1393.7" "1372.5" "1407.4" "1272.2" "1275.3" "1278.9" "1050.3" "" "" "" "" "" "" "" "" "" "" "1264.8" "1146.4" "1198.6" "1042.3" "1144.5" "1292.8" "1075.3" "1054.1" "1173.0" "1050.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "60.862" "27" "7" "20" "7" "261" "28.1" "5.91" "76.92" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "1.027" "1.135" "0.985" "1.031" "1.075" "1.043" "1.084" "1.115" "0.552" "2591.6" "2660.3" "2942.3" "2552.8" "2671.7" "2786.4" "2704.1" "2808.2" "2890.3" "1430.1" "" "" "" "" "" "" "" "" "" "" "2298.2" "2203.7" "2567.3" "1909.1" "2227.9" "2559.6" "2285.4" "2321.2" "2650.8" "1430.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "60.855" "44" "8" "21" "8" "188" "21.0" "5.14" "81.07" "8" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "Glutathione synthesis and recycling" "" "1" "0" "0.932" "0.988" "0.947" "0.961" "0.962" "0.977" "0.991" "0.994" "0.464" "3524.7" "3285.8" "3484.1" "3337.9" "3388.5" "3391.7" "3444.4" "3492.3" "3504.4" "1634.8" "" "" "" "" "" "" "" "" "" "" "3125.6" "2721.8" "3040.0" "2496.3" "2825.5" "3115.7" "2911.0" "2886.6" "3214.1" "1634.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "60.777" "39" "13" "22" "13" "360" "40.2" "10.33" "73.38" "13" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "0.994" "0.965" "1.021" "0.962" "0.909" "0.937" "1.003" "1.010" "0.572" "1611.0" "1602.1" "1555.3" "1644.1" "1549.6" "1463.8" "1509.7" "1616.5" "1627.8" "921.9" "" "" "" "" "" "" "" "" "" "" "1428.6" "1327.1" "1357.1" "1229.5" "1292.2" "1344.6" "1276.0" "1336.1" "1492.9" "921.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "High" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.000" "False" "60.769" "27" "10" "16" "10" "429" "48.7" "5.60" "55.40" "10" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Neutrophil degranulation; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "4" "0" "1.017" "1.033" "1.003" "1.056" "1.002" "1.013" "1.010" "1.025" "0.565" "1980.1" "2012.9" "2045.8" "1986.4" "2091.8" "1984.6" "2005.9" "1999.3" "2030.3" "1117.9" "" "" "" "" "" "" "" "" "" "" "1755.9" "1667.4" "1785.1" "1485.5" "1744.2" "1823.1" "1695.3" "1652.6" "1862.1" "1117.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "60.658" "38" "10" "17" "10" "290" "33.1" "6.55" "59.86" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "Small interfering RNA (siRNA) biogenesis" "" "1" "0" "0.930" "1.013" "0.901" "0.915" "0.903" "0.888" "0.925" "0.937" "0.716" "1757.4" "1633.9" "1780.8" "1584.0" "1607.5" "1587.3" "1561.4" "1626.0" "1646.5" "1258.7" "" "" "" "" "" "" "" "" "" "" "1558.5" "1353.4" "1553.8" "1184.6" "1340.5" "1458.1" "1319.6" "1344.0" "1510.1" "1258.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "60.646" "22" "13" "21" "13" "582" "64.8" "8.46" "71.78" "13" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "6" "0" "1.007" "1.006" "1.058" "0.985" "1.023" "1.004" "0.998" "0.975" "0.887" "1919.0" "1932.5" "1931.2" "2030.4" "1889.7" "1962.3" "1927.0" "1915.3" "1870.5" "1702.4" "" "" "" "" "" "" "" "" "" "" "1701.7" "1600.8" "1685.0" "1518.4" "1575.7" "1802.6" "1628.7" "1583.1" "1715.5" "1702.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "60.598" "35" "8" "41" "8" "184" "20.8" "5.31" "128.49" "8" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "Pyruvate metabolism" "" "1" "0" "0.973" "1.002" "1.017" "0.985" "0.957" "0.999" "1.053" "0.967" "0.477" "3774.9" "3672.0" "3780.7" "3838.8" "3719.9" "3614.3" "3772.9" "3976.1" "3651.4" "1799.4" "" "" "" "" "" "" "" "" "" "" "3347.5" "3041.7" "3298.9" "2870.9" "3101.9" "3320.1" "3188.7" "3286.5" "3348.9" "1799.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "60.593" "51" "9" "16" "9" "181" "20.6" "8.87" "61.78" "9" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "Neutrophil degranulation" "" "1" "0" "0.999" "1.009" "0.971" "1.054" "1.013" "0.819" "0.825" "0.837" "0.490" "2201.2" "2198.3" "2221.5" "2138.4" "2319.0" "2228.7" "1803.0" "1816.4" "1841.3" "1078.7" "" "" "" "" "" "" "" "" "" "" "1952.0" "1821.0" "1938.4" "1599.2" "1933.8" "2047.3" "1523.9" "1501.3" "1688.8" "1078.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364566389234349396" "False" "High" "IsMasterProtein" "Q04727" "Transducin-like enhancer protein 4 OS=Homo sapiens OX=9606 GN=TLE4 PE=1 SV=3" "0.000" "False" "60.429" "19" "13" "16" "7" "773" "83.7" "7.50" "63.03" "13" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7091" "ENSG00000106829" "TLE4" "F8W6T6; hsa:7091; Q04727; Q3ZCS1; Q5T1Y2; Q6PCB3; Q9BZ07; Q9BZ08; Q9BZ09; Q9NSL3; Q9ULF9" "NOTCH1 Intracellular Domain Regulates Transcription; Deactivation of the beta-catenin transactivating complex; Formation of the beta-catenin:TCF transactivating complex; Repression of WNT target genes" "" "4" "0" "0.981" "0.996" "0.878" "0.947" "1.103" "0.914" "1.013" "0.973" "0.765" "1006.1" "986.6" "1001.8" "883.1" "952.9" "1109.7" "920.0" "1019.3" "979.1" "770.0" "" "" "" "" "" "" "" "" "" "" "892.2" "817.3" "874.1" "660.4" "794.6" "1019.4" "777.6" "842.5" "897.9" "770.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248162455227524541" "False" "High" "IsMasterProtein" "Q92636" "Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2" "0.000" "False" "60.408" "15" "14" "16" "14" "917" "104.3" "6.23" "61.65" "14" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02138, Pf02893" "8439" "ENSG00000035681" "NSMAF" "B4DFB0; E9PCH0; hsa:8439; Q8IW26; Q92636" "TNFR1-mediated ceramide production" "TNF-alpha signaling pathway; Orexin receptor pathway" "3" "0" "1.050" "1.021" "1.042" "1.009" "1.060" "1.024" "1.010" "0.936" "0.931" "1807.4" "1897.3" "1844.6" "1882.9" "1823.0" "1915.7" "1851.3" "1825.7" "1692.1" "1683.4" "" "" "" "" "" "" "" "" "" "" "1602.7" "1571.7" "1609.5" "1408.1" "1520.1" "1759.8" "1564.6" "1509.1" "1551.8" "1683.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "60.383" "8" "6" "13" "2" "839" "94.5" "5.88" "56.42" "6" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "60.229" "27" "12" "17" "12" "419" "48.2" "5.71" "66.46" "12" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "76" "0" "0.983" "0.961" "0.982" "0.968" "0.960" "0.870" "0.900" "0.938" "0.808" "1924.4" "1892.4" "1850.3" "1890.3" "1863.7" "1847.1" "1674.6" "1731.7" "1804.6" "1555.4" "" "" "" "" "" "" "" "" "" "" "1706.6" "1567.6" "1614.4" "1413.7" "1554.1" "1696.8" "1415.3" "1431.4" "1655.0" "1555.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "60.220" "20" "15" "17" "15" "782" "87.9" "6.13" "56.38" "15" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "1.016" "0.987" "1.085" "1.002" "1.015" "1.000" "1.023" "0.896" "0.595" "1294.6" "1314.7" "1277.4" "1404.6" "1297.6" "1313.8" "1294.6" "1324.9" "1160.6" "770.2" "" "" "" "" "" "" "" "" "" "" "1148.0" "1089.0" "1114.6" "1050.5" "1082.0" "1206.8" "1094.2" "1095.1" "1064.4" "770.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "60.200" "18" "11" "14" "9" "655" "74.3" "6.16" "50.39" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "Maturation of nucleoprotein; Replacement of protamines by nucleosomes in the male pronucleus" "VEGFA-VEGFR2 signaling; mRNA processing" "4" "0" "0.976" "0.926" "1.031" "0.965" "0.943" "1.077" "0.895" "0.898" "2.290" "1309.4" "1278.2" "1212.1" "1350.2" "1263.4" "1234.7" "1410.0" "1172.1" "1175.5" "2998.0" "" "" "" "" "" "" "" "" "" "" "1161.2" "1058.8" "1057.7" "1009.8" "1053.5" "1134.2" "1191.7" "968.8" "1078.1" "2998.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7522921008615735421" "False" "High" "IsMasterProtein" "O75152" "Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3" "0.000" "False" "60.116" "16" "11" "13" "11" "810" "89.1" "8.37" "56.76" "11" "other metabolic processes;transport" "nucleus" "other molecular function" "Pf15663" "9877" "ENSG00000058673" "ZC3H11A" "hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.022" "0.941" "0.986" "0.884" "0.867" "0.856" "0.565" "0.892" "6.988" "713.7" "729.3" "671.3" "704.0" "630.7" "618.8" "611.1" "403.4" "636.7" "4987.3" "" "" "" "" "" "" "" "" "" "" "632.9" "604.1" "585.7" "526.5" "525.9" "568.4" "516.5" "333.5" "583.9" "4987.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "60.059" "57" "8" "19" "3" "181" "20.5" "8.82" "69.62" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "4" "1.014" "1.028" "1.017" "1.070" "1.086" "1.052" "1.043" "0.963" "0.539" "1177.5" "1194.5" "1210.4" "1197.2" "1259.4" "1278.6" "1238.4" "1228.2" "1134.4" "634.9" "" "" "" "" "" "" "" "" "" "" "1044.2" "989.5" "1056.1" "895.4" "1050.2" "1174.5" "1046.6" "1015.2" "1040.4" "634.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "60.033" "60" "7" "20" "7" "125" "13.8" "6.07" "70.15" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "0.881" "0.877" "0.744" "0.795" "0.734" "0.755" "0.893" "0.949" "0.482" "4525.5" "3987.7" "3969.4" "3366.8" "3599.6" "3323.5" "3417.5" "4041.1" "4292.7" "2179.2" "" "" "" "" "" "" "" "" "" "" "4013.2" "3303.2" "3463.5" "2517.9" "3001.6" "3053.0" "2888.3" "3340.2" "3937.0" "2179.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "60.032" "30" "13" "22" "13" "424" "46.6" "8.51" "71.29" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "HATs acetylate histones" "Mesodermal commitment pathway" "2" "0" "1.024" "1.003" "0.975" "1.005" "1.018" "0.950" "0.954" "0.923" "0.689" "2535.5" "2595.1" "2542.6" "2472.2" "2549.1" "2580.1" "2408.2" "2419.1" "2340.4" "1747.2" "" "" "" "" "" "" "" "" "" "" "2248.4" "2149.7" "2218.5" "1848.9" "2125.6" "2370.1" "2035.3" "1999.5" "2146.5" "1747.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "59.986" "49" "8" "15" "8" "181" "21.2" "7.49" "53.50" "8" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "G alpha (i) signalling events" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "4" "0" "1.074" "1.037" "1.078" "0.999" "1.041" "0.984" "0.992" "0.990" "0.897" "1048.7" "1126.4" "1088.0" "1130.8" "1047.4" "1091.9" "1032.1" "1040.3" "1038.1" "940.2" "" "" "" "" "" "" "" "" "" "" "930.0" "933.1" "949.3" "845.7" "873.4" "1003.1" "872.2" "859.9" "952.1" "940.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "59.966" "57" "7" "13" "7" "165" "19.0" "5.21" "55.25" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "1.068" "1.028" "1.035" "1.059" "1.022" "1.069" "1.056" "1.043" "0.689" "1421.0" "1517.9" "1460.3" "1470.6" "1504.7" "1451.8" "1519.5" "1500.4" "1482.4" "978.4" "" "" "" "" "" "" "" "" "" "" "1260.1" "1257.3" "1274.2" "1099.8" "1254.7" "1333.6" "1284.2" "1240.2" "1359.5" "978.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "59.953" "16" "7" "20" "7" "478" "50.7" "9.10" "66.19" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "0.953" "1.015" "1.023" "0.968" "1.020" "1.021" "1.022" "0.948" "0.567" "1376.8" "1312.1" "1396.9" "1408.9" "1332.1" "1404.0" "1405.7" "1406.6" "1305.1" "781.1" "" "" "" "" "" "" "" "" "" "" "1220.9" "1086.9" "1218.9" "1053.7" "1110.8" "1289.7" "1188.0" "1162.7" "1196.9" "781.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "59.876" "11" "9" "12" "9" "962" "109.9" "5.39" "47.83" "9" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "tRNA processing in the nucleus" "" "1" "0" "1.042" "0.969" "1.062" "0.993" "0.965" "1.125" "0.662" "0.920" "6.743" "516.5" "538.4" "500.5" "548.7" "512.9" "498.2" "580.9" "342.1" "475.4" "3482.5" "" "" "" "" "" "" "" "" "" "" "458.0" "446.0" "436.7" "410.4" "427.7" "457.6" "490.9" "282.7" "436.0" "3482.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-60388765585118576" "False" "High" "IsMasterProtein" "Q9H875" "PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1" "0.000" "False" "59.854" "58" "10" "13" "10" "184" "21.0" "9.79" "55.18" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06658" "79706" "ENSG00000128563" "PRKRIP1" "B4DGM2; hsa:79706; Q8NDM6; Q96CF8; Q9H875" "mRNA Splicing - Major Pathway" "" "1" "0" "0.935" "0.897" "0.985" "0.904" "0.889" "0.828" "0.899" "0.888" "0.550" "1432.3" "1338.8" "1285.0" "1410.4" "1294.9" "1273.4" "1185.9" "1287.8" "1272.5" "788.1" "" "" "" "" "" "" "" "" "" "" "1270.2" "1109.0" "1121.2" "1054.8" "1079.7" "1169.8" "1002.2" "1064.4" "1167.0" "788.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "59.789" "19" "8" "18" "8" "419" "48.2" "6.15" "66.51" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "9" "0" "0.923" "0.817" "0.953" "0.847" "0.818" "0.931" "0.189" "0.829" "14.638" "760.9" "702.2" "621.6" "724.9" "644.3" "622.3" "708.3" "143.7" "631.0" "11138.2" "" "" "" "" "" "" "" "" "" "" "674.8" "581.7" "542.4" "542.1" "537.3" "571.6" "598.6" "118.8" "578.7" "11138.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "59.788" "43" "6" "16" "6" "158" "18.3" "7.88" "70.17" "6" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.018" "1.005" "1.067" "1.031" "1.023" "0.985" "0.981" "0.977" "0.921" "1465.0" "1490.6" "1472.4" "1563.6" "1510.6" "1499.2" "1442.6" "1436.5" "1431.6" "1348.6" "" "" "" "" "" "" "" "" "" "" "1299.1" "1234.8" "1284.7" "1169.4" "1259.6" "1377.2" "1219.2" "1187.4" "1313.0" "1348.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "59.783" "41" "7" "15" "7" "186" "20.5" "5.41" "57.18" "7" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "8" "0" "0.985" "0.995" "0.981" "1.003" "1.078" "1.044" "1.068" "1.044" "0.524" "2503.1" "2466.0" "2489.9" "2454.3" "2510.8" "2697.8" "2613.8" "2672.4" "2613.5" "1310.7" "" "" "" "" "" "" "" "" "" "" "2219.7" "2042.7" "2172.6" "1835.5" "2093.7" "2478.3" "2209.0" "2208.9" "2396.9" "1310.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "59.779" "50" "10" "26" "7" "200" "22.5" "8.38" "93.60" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "5" "1" "0.979" "1.030" "0.985" "0.986" "0.994" "0.971" "1.012" "0.935" "0.691" "2210.7" "2163.4" "2276.7" "2176.5" "2179.4" "2197.9" "2145.7" "2237.2" "2067.1" "1527.8" "" "" "" "" "" "" "" "" "" "" "1960.4" "1792.1" "1986.5" "1627.8" "1817.3" "2019.0" "1813.5" "1849.2" "1895.8" "1527.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991774416485678648" "False" "High" "IsMasterProtein" "P51948" "CDK-activating kinase assembly factor MAT1 OS=Homo sapiens OX=9606 GN=MNAT1 PE=1 SV=1" "0.000" "False" "59.720" "24" "8" "14" "8" "309" "35.8" "6.09" "56.83" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf06391, Pf17121" "4331" "ENSG00000020426" "MNAT1" "G3V1U8; hsa:4331; P51948; Q15817; Q6ICQ7" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "38" "0" "1.051" "0.998" "1.079" "1.027" "1.035" "1.041" "1.016" "0.971" "0.688" "1627.1" "1710.3" "1624.1" "1755.0" "1671.7" "1683.8" "1693.4" "1653.2" "1580.1" "1119.5" "" "" "" "" "" "" "" "" "" "" "1442.9" "1416.8" "1417.1" "1312.5" "1393.9" "1546.8" "1431.2" "1366.5" "1449.2" "1119.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "59.700" "17" "12" "13" "12" "843" "100.1" "6.32" "50.59" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "mRNA Splicing - Major Pathway" "" "1" "0" "1.091" "0.979" "1.069" "0.944" "1.008" "0.992" "0.893" "0.971" "3.521" "958.7" "1045.7" "938.1" "1024.7" "905.1" "966.1" "951.4" "856.3" "931.1" "3375.1" "" "" "" "" "" "" "" "" "" "" "850.1" "866.2" "818.5" "766.3" "754.7" "887.5" "804.1" "707.8" "854.0" "3375.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6687881647514235914" "False" "High" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "0.000" "False" "59.683" "27" "7" "11" "7" "362" "39.3" "5.52" "46.45" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Retrograde transport at the Trans-Golgi-Network" "Metapathway biotransformation Phase I and II" "2" "0" "0.969" "1.024" "1.027" "0.998" "1.010" "1.205" "1.166" "1.101" "1.025" "1047.3" "1014.8" "1072.2" "1075.9" "1045.5" "1057.8" "1262.2" "1220.9" "1153.1" "1073.8" "" "" "" "" "" "" "" "" "" "" "928.7" "840.6" "935.5" "804.6" "871.8" "971.7" "1066.8" "1009.2" "1057.5" "1073.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.000" "False" "59.595" "44" "8" "23" "8" "231" "24.7" "7.23" "83.95" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "L1CAM interactions" "" "1" "0" "1.015" "1.056" "1.025" "1.041" "1.016" "1.076" "1.063" "1.050" "0.677" "2684.0" "2722.9" "2833.7" "2752.0" "2795.3" "2728.0" "2888.4" "2852.6" "2819.1" "1815.8" "" "" "" "" "" "" "" "" "" "" "2380.1" "2255.5" "2472.6" "2058.2" "2330.9" "2506.0" "2441.1" "2357.9" "2585.5" "1815.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3718082725162177882" "False" "High" "IsMasterProtein" "O95822" "Malonyl-CoA decarboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=MLYCD PE=1 SV=3" "0.000" "False" "59.577" "23" "10" "13" "10" "493" "55.0" "8.95" "50.82" "10" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05292, Pf17408" "23417" "ENSG00000103150" "MLYCD" "hsa:23417; O95822; Q9UNU5; Q9Y3F2" "" "" "0" "0" "1.060" "1.012" "1.158" "1.078" "1.099" "1.085" "1.018" "0.918" "0.541" "1313.7" "1392.3" "1329.1" "1520.9" "1416.5" "1444.0" "1425.7" "1337.8" "1206.5" "710.7" "" "" "" "" "" "" "" "" "" "" "1164.9" "1153.3" "1159.7" "1137.5" "1181.2" "1326.5" "1204.9" "1105.8" "1106.5" "710.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "59.537" "41" "9" "22" "9" "234" "26.1" "7.78" "68.32" "9" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "0.970" "0.985" "0.955" "0.979" "1.009" "0.989" "1.026" "1.023" "0.523" "2412.3" "2340.5" "2375.7" "2303.1" "2362.6" "2435.0" "2386.0" "2475.8" "2467.1" "1260.9" "" "" "" "" "" "" "" "" "" "" "2139.2" "1938.8" "2072.9" "1722.4" "1970.1" "2236.9" "2016.5" "2046.4" "2262.7" "1260.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3672343249527762985" "False" "High" "IsMasterProtein" "Q9H8M7" "Ubiquitin carboxyl-terminal hydrolase MINDY-3 OS=Homo sapiens OX=9606 GN=MINDY3 PE=1 SV=1" "0.000" "False" "59.510" "18" "8" "15" "8" "445" "49.7" "4.77" "55.67" "8" "protein metabolism;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13898" "80013" "ENSG00000148481" "MINDY3" "Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; Q9H8M7" "" "" "0" "0" "0.972" "0.951" "0.906" "0.895" "0.900" "0.843" "0.901" "0.916" "0.544" "2297.5" "2233.7" "2184.6" "2082.3" "2055.7" "2066.6" "1936.8" "2071.1" "2104.6" "1249.3" "" "" "" "" "" "" "" "" "" "" "2037.4" "1850.3" "1906.1" "1557.3" "1714.2" "1898.4" "1636.9" "1711.9" "1930.2" "1249.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "59.438" "32" "12" "14" "12" "400" "46.5" "5.24" "57.81" "12" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "TBC/RABGAPs" "" "1" "0" "1.024" "0.964" "1.053" "1.036" "1.036" "1.040" "1.094" "1.024" "0.617" "1171.2" "1198.7" "1128.8" "1232.8" "1213.4" "1213.7" "1218.3" "1281.1" "1199.0" "723.1" "" "" "" "" "" "" "" "" "" "" "1038.6" "992.9" "984.9" "922.0" "1011.8" "1114.9" "1029.6" "1058.9" "1099.7" "723.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952691654267697192" "False" "High" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "0.000" "False" "59.402" "19" "9" "11" "9" "660" "74.4" "8.16" "41.61" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "TYSND1 cleaves peroxisomal proteins" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "8" "0" "1.067" "1.023" "1.020" "1.087" "1.065" "1.040" "1.137" "1.011" "0.449" "787.1" "839.6" "805.1" "802.8" "855.6" "838.0" "818.2" "895.0" "795.5" "353.7" "" "" "" "" "" "" "" "" "" "" "697.9" "695.5" "702.5" "600.4" "713.4" "769.8" "691.5" "739.8" "729.6" "353.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "59.400" "53" "8" "14" "8" "190" "20.7" "9.54" "52.78" "8" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "1.075" "1.076" "1.154" "1.117" "1.135" "1.236" "1.177" "1.099" "0.769" "374.0" "402.1" "402.4" "431.5" "417.8" "424.5" "462.3" "440.2" "410.9" "287.5" "" "" "" "" "" "" "" "" "" "" "331.6" "333.1" "351.2" "322.7" "348.4" "390.0" "390.7" "363.8" "376.9" "287.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.000" "False" "59.383" "43" "9" "18" "9" "205" "23.5" "5.08" "72.17" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "13" "0" "1.067" "1.024" "1.031" "0.986" "0.990" "0.898" "0.828" "0.744" "1.991" "1996.3" "2129.3" "2043.7" "2057.5" "1968.2" "1976.2" "1793.3" "1653.8" "1484.7" "3973.9" "" "" "" "" "" "" "" "" "" "" "1770.3" "1763.8" "1783.3" "1538.7" "1641.2" "1815.4" "1515.6" "1367.0" "1361.7" "3973.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3022549876159517749" "False" "High" "IsMasterProtein" "Q9H8W4" "Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1" "0.000" "False" "59.333" "41" "7" "10" "7" "249" "27.8" "8.21" "45.99" "7" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00169, Pf01363" "79666" "ENSG00000175895" "PLEKHF2" "hsa:79666; Q9H8W4" "" "" "0" "0" "1.063" "1.080" "1.046" "1.077" "1.047" "1.091" "0.749" "1.041" "5.213" "441.3" "469.1" "476.8" "461.9" "475.5" "462.1" "481.5" "330.7" "459.4" "2300.7" "" "" "" "" "" "" "" "" "" "" "391.4" "388.6" "416.0" "345.4" "396.5" "424.5" "406.9" "273.3" "421.4" "2300.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "59.257" "22" "9" "29" "3" "434" "49.7" "6.67" "90.88" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "" "2q37 copy number variation syndrome" "1" "0" "1.048" "0.994" "1.108" "1.138" "1.084" "1.017" "0.976" "1.005" "0.570" "338.4" "354.7" "336.2" "375.1" "385.0" "366.7" "344.1" "330.3" "340.1" "192.9" "" "" "" "" "" "" "" "" "" "" "300.1" "293.8" "293.4" "280.5" "321.0" "336.8" "290.8" "273.0" "311.9" "192.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "59.256" "39" "10" "15" "10" "329" "37.6" "5.33" "53.10" "10" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "TGF-beta signaling pathway" "3" "0" "1.055" "0.962" "1.029" "1.021" "0.993" "0.976" "0.748" "1.009" "5.706" "861.6" "909.3" "829.1" "886.8" "879.7" "855.2" "840.9" "644.2" "869.1" "4916.4" "" "" "" "" "" "" "" "" "" "" "764.0" "753.2" "723.4" "663.2" "733.5" "785.6" "710.7" "532.5" "797.1" "4916.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "59.235" "31" "7" "13" "7" "244" "27.3" "5.15" "46.82" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "Post-chaperonin tubulin folding pathway" "" "1" "0" "1.045" "0.968" "0.905" "0.912" "0.928" "0.953" "0.858" "0.936" "3.506" "781.0" "816.0" "756.0" "706.6" "712.2" "724.6" "744.2" "670.1" "730.8" "2737.8" "" "" "" "" "" "" "" "" "" "" "692.5" "675.9" "659.6" "528.5" "593.9" "665.6" "629.0" "553.9" "670.3" "2737.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7428234003778738305" "False" "High" "IsMasterProtein" "Q9BRT2" "Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1" "0.000" "False" "59.206" "67" "8" "12" "8" "126" "14.9" "7.37" "49.95" "8" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf20180" "84300" "ENSG00000137288" "UQCC2" "B2R4I0; Q9BRT2" "" "Mitochondrial complex III assembly" "1" "0" "0.978" "0.961" "0.971" "1.048" "1.077" "0.980" "1.086" "1.067" "0.398" "1292.7" "1264.0" "1241.9" "1255.1" "1354.5" "1392.3" "1266.7" "1404.3" "1378.8" "514.3" "" "" "" "" "" "" "" "" "" "" "1146.3" "1047.0" "1083.7" "938.7" "1129.5" "1279.0" "1070.5" "1160.7" "1264.6" "514.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.000" "False" "58.970" "52" "6" "10" "6" "142" "16.3" "4.79" "43.74" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism" "42" "0" "0.985" "0.958" "1.000" "1.003" "1.012" "0.924" "0.898" "0.901" "0.553" "1010.3" "995.4" "968.1" "1010.0" "1013.4" "1022.2" "933.7" "906.8" "910.6" "558.9" "" "" "" "" "" "" "" "" "" "" "895.9" "824.5" "844.7" "755.4" "845.0" "939.0" "789.1" "749.5" "835.1" "558.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "58.924" "39" "6" "16" "6" "172" "19.2" "5.40" "58.94" "6" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "0.996" "1.014" "0.948" "0.996" "1.107" "0.991" "1.015" "1.103" "0.918" "886.6" "883.2" "899.1" "840.4" "883.5" "981.4" "878.3" "900.0" "977.9" "813.9" "" "" "" "" "" "" "" "" "" "" "786.3" "731.6" "784.5" "628.5" "736.7" "901.5" "742.3" "743.9" "896.9" "813.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "58.921" "64" "7" "26" "7" "105" "11.7" "9.57" "92.51" "7" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "36" "0" "0.953" "1.004" "0.947" "0.985" "0.971" "0.970" "1.049" "0.993" "0.519" "1894.8" "1806.3" "1903.3" "1794.1" "1865.7" "1840.4" "1837.1" "1988.3" "1881.0" "982.6" "" "" "" "" "" "" "" "" "" "" "1680.3" "1496.2" "1660.7" "1341.8" "1555.7" "1690.6" "1552.7" "1643.5" "1725.1" "982.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747633478491734615" "False" "High" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "0.000" "False" "58.910" "30" "9" "13" "9" "349" "39.0" "6.52" "55.32" "9" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "1.061" "1.020" "1.115" "1.069" "1.071" "1.096" "1.049" "0.952" "0.567" "1216.6" "1290.4" "1241.4" "1356.1" "1300.1" "1302.9" "1333.7" "1276.7" "1158.3" "689.3" "" "" "" "" "" "" "" "" "" "" "1078.9" "1068.9" "1083.2" "1014.2" "1084.1" "1196.9" "1127.2" "1055.3" "1062.3" "689.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "58.905" "26" "8" "9" "8" "454" "49.8" "5.10" "44.02" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "Negative regulation of NMDA receptor-mediated neuronal transmission" "" "1" "0" "0.998" "0.990" "1.075" "1.007" "0.946" "1.038" "0.947" "0.978" "1.494" "554.4" "553.2" "548.8" "595.7" "558.3" "524.5" "575.6" "524.9" "542.3" "828.2" "" "" "" "" "" "" "" "" "" "" "491.6" "458.2" "478.8" "445.5" "465.6" "481.8" "486.5" "433.9" "497.4" "828.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469861955524626528" "False" "High" "IsMasterProtein" "Q9BTX7" "Alpha-tocopherol transfer protein-like OS=Homo sapiens OX=9606 GN=TTPAL PE=1 SV=2" "0.000" "False" "58.900" "30" "8" "15" "8" "342" "38.5" "6.44" "57.33" "8" "" "" "other molecular function" "Pf00650, Pf03765" "79183" "ENSG00000124120" "TTPAL" "E1P5X3; hsa:79183; Q5QPC1; Q9BTX7; Q9H1G2; Q9NQG8" "" "" "0" "0" "1.088" "1.059" "1.004" "1.058" "1.049" "1.048" "1.023" "1.007" "0.677" "829.6" "902.8" "878.6" "832.8" "877.9" "870.0" "869.5" "848.8" "835.0" "561.3" "" "" "" "" "" "" "" "" "" "" "735.6" "747.8" "766.6" "622.8" "732.0" "799.2" "734.8" "701.6" "765.8" "561.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "58.888" "23" "10" "21" "10" "416" "46.1" "6.52" "77.47" "10" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "Complement and coagulation cascades; NRF2 pathway" "8" "0" "1.140" "1.030" "0.901" "1.159" "0.908" "1.134" "1.229" "1.043" "0.559" "2653.2" "3023.7" "2733.0" "2389.4" "3075.0" "2409.5" "3009.4" "3260.0" "2767.1" "1483.2" "" "" "" "" "" "" "" "" "" "" "2352.8" "2504.7" "2384.7" "1786.9" "2564.1" "2213.4" "2543.4" "2694.6" "2537.8" "1483.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "58.843" "21" "8" "14" "8" "452" "50.9" "6.54" "58.88" "8" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "5" "0" "0.954" "0.958" "1.022" "1.013" "1.034" "1.159" "1.195" "1.009" "0.697" "2095.8" "1998.6" "2008.0" "2142.3" "2123.9" "2166.2" "2429.8" "2503.6" "2115.3" "1460.7" "" "" "" "" "" "" "" "" "" "" "1858.5" "1655.6" "1752.1" "1602.1" "1771.1" "1989.9" "2053.6" "2069.4" "1940.0" "1460.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1849398190907063362" "False" "High" "IsMasterProtein" "P35813" "Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1" "0.000" "False" "58.764" "25" "8" "14" "7" "382" "42.4" "5.36" "53.79" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5494" "ENSG00000100614" "PPM1A" "B5BU11; hsa:5494; J3KNM0; O75551; P35813" "Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "TGF-beta signaling pathway; MAPK signaling pathway" "4" "1" "0.990" "0.985" "1.032" "0.974" "0.975" "0.961" "0.976" "0.938" "1.272" "952.2" "943.1" "938.0" "983.1" "927.2" "928.6" "914.7" "929.0" "892.9" "1211.0" "" "" "" "" "" "" "" "" "" "" "844.4" "781.2" "818.5" "735.2" "773.1" "853.0" "773.1" "767.9" "818.9" "1211.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2749057131699299074" "False" "High" "IsMasterProtein" "Q9BSY4" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 OS=Homo sapiens OX=9606 GN=CHCHD5 PE=1 SV=1" "0.000" "False" "58.748" "62" "5" "15" "5" "110" "12.4" "6.73" "62.97" "5" "other metabolic processes" "mitochondrion" "" "Pf06747, Pf16860" "84269" "ENSG00000125611" "CHCHD5" "hsa:84269; Q585T4; Q8N8C4; Q9BSY4" "Mitochondrial protein import" "2q13 copy number variation syndrome" "2" "0" "0.986" "0.992" "1.102" "1.043" "0.988" "1.092" "0.988" "1.020" "0.726" "666.9" "657.5" "661.9" "734.8" "695.4" "658.9" "728.3" "658.7" "680.1" "484.4" "" "" "" "" "" "" "" "" "" "" "591.4" "544.7" "577.5" "549.5" "579.9" "605.3" "615.5" "544.5" "623.7" "484.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "58.715" "11" "9" "11" "8" "920" "106.1" "9.98" "44.21" "9" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "" "Interactome of polycomb repressive complex 2 (PRC2)" "1" "0" "1.021" "1.037" "1.015" "0.954" "1.013" "0.969" "0.991" "0.976" "0.600" "883.3" "901.6" "915.7" "896.7" "842.9" "894.5" "855.6" "875.6" "862.5" "530.0" "" "" "" "" "" "" "" "" "" "" "783.3" "746.8" "799.0" "670.6" "702.9" "821.7" "723.1" "723.7" "791.1" "530.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "58.706" "44" "6" "14" "5" "142" "16.7" "5.29" "61.14" "6" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "1" "1.056" "1.130" "1.041" "1.140" "1.053" "1.104" "1.089" "1.218" "0.573" "2778.4" "2934.4" "3140.4" "2892.0" "3168.0" "2925.3" "3066.4" "3024.9" "3383.0" "1590.7" "" "" "" "" "" "" "" "" "" "" "2463.8" "2430.7" "2740.2" "2162.8" "2641.6" "2687.2" "2591.6" "2500.3" "3102.7" "1590.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "58.583" "39" "8" "14" "8" "237" "26.8" "6.87" "57.22" "8" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "Mitochondrial RNA degradation" "" "1" "0" "0.924" "0.934" "0.976" "0.954" "1.042" "0.958" "0.994" "0.964" "0.426" "1530.2" "1414.2" "1428.6" "1493.8" "1460.3" "1593.8" "1466.0" "1521.7" "1474.8" "652.2" "" "" "" "" "" "" "" "" "" "" "1357.0" "1171.4" "1246.5" "1117.1" "1217.7" "1464.1" "1239.0" "1257.8" "1352.6" "652.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4655855300014543961" "False" "High" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "0.000" "False" "58.565" "27" "11" "12" "11" "500" "55.6" "7.18" "43.68" "11" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Somitogenesis; Formation of paraxial mesoderm; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway" "20" "0" "1.051" "0.986" "1.069" "1.056" "1.123" "1.046" "1.095" "1.017" "0.565" "803.9" "844.5" "792.9" "859.8" "849.3" "902.6" "840.7" "880.6" "817.8" "453.9" "" "" "" "" "" "" "" "" "" "" "712.9" "699.5" "691.8" "643.0" "708.2" "829.1" "710.5" "727.9" "750.0" "453.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967759419043337591" "False" "High" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "0.000" "False" "58.504" "19" "10" "14" "10" "578" "63.7" "7.36" "52.06" "10" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "Peroxisomal protein import; Alpha-oxidation of phytanate" "" "2" "0" "1.013" "0.920" "0.978" "0.924" "0.962" "0.903" "0.896" "0.923" "0.539" "1456.1" "1475.6" "1340.1" "1424.0" "1346.1" "1400.6" "1314.5" "1305.0" "1344.6" "784.2" "" "" "" "" "" "" "" "" "" "" "1291.2" "1222.3" "1169.3" "1065.0" "1122.5" "1286.6" "1111.0" "1078.7" "1233.2" "784.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "58.490" "30" "13" "20" "13" "435" "49.6" "9.54" "70.23" "13" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Potential therapeutics for SARS; MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "21" "0" "0.948" "1.033" "1.033" "1.012" "0.967" "0.967" "1.031" "0.965" "0.857" "2196.6" "2082.4" "2268.7" "2269.9" "2223.9" "2124.8" "2124.0" "2265.1" "2120.4" "1882.4" "" "" "" "" "" "" "" "" "" "" "1947.9" "1724.9" "1979.6" "1697.6" "1854.4" "1951.9" "1795.1" "1872.2" "1944.7" "1882.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "58.458" "41" "8" "18" "8" "157" "17.8" "11.25" "64.98" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.030" "1.005" "0.977" "1.007" "0.949" "0.914" "0.878" "0.941" "1.233" "2508.1" "2582.3" "2519.4" "2450.3" "2526.0" "2379.2" "2292.1" "2201.3" "2361.3" "3091.9" "" "" "" "" "" "" "" "" "" "" "2224.1" "2139.0" "2198.3" "1832.5" "2106.3" "2185.6" "1937.2" "1819.5" "2165.6" "3091.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8263203131680576726" "False" "High" "IsMasterProtein" "Cont_P13717" "Nuclease OS=Serratia marcescens OX=615 GN=nucA PE=1 SV=2" "0.000" "True" "58.419" "37" "6" "7" "6" "266" "28.9" "7.42" "36.40" "6" "" "non-structural extracellular" "nucleic acid binding activity;other molecular function" "Pf01223" "66715254" "" "nucA" "A0A2V4G0H5; A0A5C7C9X8; A0A656VIL2; P13717" "" "" "0" "0" "0.891" "0.868" "0.921" "0.904" "1.039" "0.944" "0.893" "0.795" "0.411" "1271.8" "1133.8" "1103.8" "1171.3" "1149.4" "1321.0" "1200.0" "1136.1" "1010.7" "522.9" "" "" "" "" "" "" "" "" "" "" "1127.8" "939.2" "963.1" "876.0" "958.5" "1213.5" "1014.2" "939.1" "927.0" "522.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4353551603118957972" "False" "High" "IsMasterProtein" "P34949" "Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2" "0.000" "False" "58.374" "18" "6" "11" "6" "423" "46.6" "5.95" "45.18" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01238, Pf20511, Pf20512" "4351" "ENSG00000178802" "MPI" "A8K8K9; hsa:4351; P34949; Q96AB0" "Synthesis of GDP-mannose; Defective MPI causes MPI-CDG" "N-glycan biosynthesis" "3" "0" "1.041" "0.972" "1.039" "0.986" "0.979" "0.885" "0.949" "0.986" "1.718" "749.9" "780.2" "729.2" "778.9" "739.4" "733.8" "664.0" "711.5" "739.7" "1288.6" "" "" "" "" "" "" "" "" "" "" "665.0" "646.3" "636.3" "582.5" "616.6" "674.1" "561.1" "588.1" "678.4" "1288.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "58.356" "31" "6" "14" "6" "182" "21.5" "6.60" "55.00" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Transcriptional regulation of granulopoiesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Estrogen-dependent gene expression; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; RUNX2 regulates osteoblast differentiation; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "27" "0" "1.053" "0.928" "1.062" "1.013" "0.861" "1.061" "0.811" "0.917" "4.038" "1349.1" "1420.7" "1251.5" "1432.1" "1366.2" "1161.3" "1431.4" "1094.5" "1237.5" "5447.8" "" "" "" "" "" "" "" "" "" "" "1196.3" "1176.9" "1092.0" "1071.0" "1139.2" "1066.8" "1209.8" "904.6" "1135.0" "5447.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "58.348" "13" "13" "14" "12" "968" "112.1" "6.95" "50.29" "13" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "" "4" "0" "0.958" "0.893" "0.985" "0.933" "0.926" "0.901" "0.494" "0.983" "7.614" "1007.5" "965.3" "899.5" "992.0" "940.1" "932.7" "907.6" "497.2" "990.5" "7671.0" "" "" "" "" "" "" "" "" "" "" "893.4" "799.6" "784.9" "741.9" "783.9" "856.8" "767.1" "411.0" "908.4" "7671.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "58.338" "15" "9" "12" "8" "863" "98.2" "6.46" "49.87" "9" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "" "Lung fibrosis" "1" "0" "0.911" "0.841" "0.978" "0.835" "0.748" "1.178" "1.007" "0.990" "3.112" "815.7" "743.4" "685.7" "798.0" "680.8" "610.2" "960.5" "821.3" "807.9" "2538.7" "" "" "" "" "" "" "" "" "" "" "723.3" "615.8" "598.3" "596.8" "567.7" "560.5" "811.8" "678.8" "740.9" "2538.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "58.308" "59" "6" "19" "6" "125" "14.2" "5.26" "68.76" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "Eukaryotic Translation Termination; rRNA modification in the nucleus and cytosol; tRNA modification in the nucleus and cytosol; Methylation" "" "4" "0" "1.057" "1.059" "1.088" "1.101" "1.028" "1.079" "1.053" "0.978" "0.677" "1176.3" "1243.8" "1245.2" "1279.6" "1295.0" "1209.5" "1269.3" "1238.8" "1150.4" "796.6" "" "" "" "" "" "" "" "" "" "" "1043.2" "1030.3" "1086.5" "957.0" "1079.8" "1111.1" "1072.7" "1024.0" "1055.0" "796.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "58.308" "20" "9" "11" "9" "535" "59.8" "5.05" "38.28" "9" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "0.998" "0.885" "1.016" "0.974" "0.946" "0.918" "0.902" "0.881" "1.039" "705.7" "704.1" "624.9" "716.8" "687.6" "667.9" "647.6" "636.3" "621.9" "733.1" "" "" "" "" "" "" "" "" "" "" "625.8" "583.3" "545.2" "536.1" "573.4" "613.6" "547.4" "525.9" "570.3" "733.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "58.297" "35" "11" "17" "11" "293" "31.3" "10.24" "58.63" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Regulation of expression of SLITs and ROBOs; Protein methylation; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; RMTs methylate histone arginines; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "22" "0" "0.976" "1.027" "1.062" "1.043" "0.845" "0.897" "0.812" "0.926" "2.544" "1308.6" "1277.3" "1343.7" "1389.3" "1364.5" "1106.3" "1173.8" "1062.9" "1211.8" "3329.0" "" "" "" "" "" "" "" "" "" "" "1160.4" "1058.1" "1172.4" "1039.0" "1137.8" "1016.2" "992.0" "878.5" "1111.4" "3329.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "58.267" "39" "5" "28" "5" "176" "18.4" "9.44" "96.48" "5" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "0.919" "0.912" "0.930" "0.868" "0.874" "0.863" "0.907" "0.888" "0.409" "2330.1" "2141.2" "2124.8" "2165.9" "2021.9" "2035.3" "2010.5" "2113.2" "2068.7" "952.1" "" "" "" "" "" "" "" "" "" "" "2066.2" "1773.6" "1854.0" "1619.8" "1686.0" "1869.7" "1699.2" "1746.7" "1897.3" "952.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "58.265" "35" "10" "14" "10" "285" "33.0" "5.17" "54.47" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "5" "0" "0.981" "0.973" "1.002" "1.003" "1.026" "0.975" "0.991" "0.974" "0.739" "1282.8" "1258.5" "1248.8" "1285.6" "1286.2" "1315.7" "1250.5" "1271.0" "1249.5" "948.5" "" "" "" "" "" "" "" "" "" "" "1137.6" "1042.5" "1089.6" "961.5" "1072.6" "1208.6" "1056.8" "1050.6" "1146.0" "948.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "568464796837822948" "False" "High" "IsMasterProtein" "O43823" "A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1" "0.000" "False" "58.244" "19" "11" "14" "11" "692" "76.1" "5.15" "50.74" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "10270" "ENSG00000105127" "AKAP8" "hsa:10270; O43823" "" "G protein signaling pathways" "1" "0" "0.988" "0.913" "0.968" "0.929" "0.960" "1.009" "0.901" "1.025" "2.621" "1775.1" "1753.9" "1620.4" "1717.6" "1649.1" "1704.7" "1790.8" "1599.7" "1818.7" "4652.0" "" "" "" "" "" "" "" "" "" "" "1574.1" "1452.8" "1413.8" "1284.5" "1375.1" "1566.0" "1513.5" "1322.3" "1668.0" "4652.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3739343134974919134" "False" "High" "IsMasterProtein" "Q92804" "TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1" "0.000" "False" "58.224" "20" "7" "27" "4" "592" "61.8" "8.02" "95.48" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8148" "ENSG00000270647; ENSG00000276833" "TAF15" "B2R837; hsa:8148; Q86X94; Q92751; Q92804" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "17q12 copy number variation syndrome" "10" "0" "1.040" "0.928" "0.765" "0.941" "1.009" "0.988" "0.907" "0.989" "0.740" "544.8" "566.7" "505.4" "416.8" "512.7" "549.6" "538.1" "494.3" "539.1" "403.2" "" "" "" "" "" "" "" "" "" "" "483.2" "469.4" "441.0" "311.7" "427.5" "504.9" "454.8" "408.5" "494.4" "403.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "58.137" "26" "7" "9" "7" "368" "40.9" "7.83" "43.53" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "30" "0" "1.016" "1.010" "0.990" "1.025" "1.001" "0.996" "0.929" "0.992" "1.498" "924.4" "939.4" "933.8" "914.8" "947.5" "924.9" "920.9" "858.8" "916.8" "1384.4" "" "" "" "" "" "" "" "" "" "" "819.8" "778.2" "814.7" "684.2" "790.1" "849.6" "778.3" "709.9" "840.8" "1384.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "58.124" "32" "12" "17" "12" "372" "41.9" "7.31" "53.16" "12" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "GDP-fucose biosynthesis" "" "1" "0" "0.960" "0.991" "0.941" "0.970" "1.001" "0.927" "1.017" "0.907" "0.557" "2025.5" "1945.1" "2007.2" "1905.3" "1965.2" "2026.5" "1878.3" "2059.4" "1837.6" "1127.9" "" "" "" "" "" "" "" "" "" "" "1796.1" "1611.2" "1751.3" "1424.9" "1638.7" "1861.6" "1587.5" "1702.2" "1685.3" "1127.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "58.030" "39" "10" "24" "10" "213" "23.9" "8.76" "78.07" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "Macroautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "0.919" "0.970" "0.894" "0.911" "0.940" "0.945" "0.963" "0.971" "0.535" "5157.1" "4738.0" "5002.0" "4610.5" "4696.7" "4845.5" "4872.6" "4965.9" "5008.5" "2759.0" "" "" "" "" "" "" "" "" "" "" "4573.2" "3924.7" "4364.5" "3448.1" "3916.4" "4451.2" "4118.1" "4104.7" "4593.5" "2759.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "57.959" "27" "13" "15" "13" "492" "57.2" "5.92" "52.35" "13" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "mRNA Splicing - Major Pathway" "" "1" "0" "1.050" "0.993" "0.993" "0.971" "0.978" "0.979" "0.893" "0.946" "2.274" "1661.6" "1744.8" "1650.3" "1650.5" "1613.5" "1624.4" "1627.1" "1484.6" "1571.4" "3778.1" "" "" "" "" "" "" "" "" "" "" "1473.5" "1445.3" "1440.0" "1234.3" "1345.5" "1492.2" "1375.1" "1227.1" "1441.2" "3778.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5634495844004760" "False" "High" "IsMasterProtein" "O60907" "F-box-like/WD repeat-containing protein TBL1X OS=Homo sapiens OX=9606 GN=TBL1X PE=1 SV=3" "0.000" "False" "57.893" "19" "7" "12" "1" "577" "62.5" "6.55" "59.83" "7" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "6907" "ENSG00000101849" "TBL1X" "A8K044; A8K4J7; hsa:6907; O60907; Q86UY2" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "Ectoderm differentiation; Ectoderm differentiation; Rett syndrome" "22" "0" "1.043" "0.785" "1.299" "0.906" "0.894" "1.117" "1.021" "0.939" "0.730" "84.1" "87.7" "66.0" "109.3" "76.2" "75.2" "94.0" "85.8" "79.0" "61.4" "" "" "" "" "" "" "" "" "" "" "74.6" "72.7" "57.6" "81.7" "63.5" "69.1" "79.4" "71.0" "72.5" "61.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3281625266906913156" "False" "High" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "0.000" "False" "57.885" "7" "15" "15" "15" "2002" "224.2" "5.55" "51.39" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "0" "1.025" "1.039" "1.013" "1.031" "1.069" "1.114" "1.039" "1.096" "1.755" "1578.8" "1618.5" "1640.4" "1599.4" "1628.1" "1687.6" "1759.2" "1640.1" "1731.2" "2771.1" "" "" "" "" "" "" "" "" "" "" "1400.1" "1340.7" "1431.3" "1196.1" "1357.6" "1550.2" "1486.8" "1355.7" "1587.7" "2771.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1864245465552936513" "False" "High" "IsMasterProtein" "Cont_Q5KR48" "Tropomyosin beta chain OS=Bos taurus OX=9913 GN=TPM2 PE=2 SV=1" "0.000" "True" "57.865" "32" "13" "29" "1" "284" "32.8" "4.70" "89.58" "13" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00261" "100471103; 101114931; 101353128; 101382361; 101614872; 101678214; 101831872; 101976903; 102178827; 102505904; 102542609; 102737237; 102917563; 102952315; 102988158; 103084875; 103265468; 103741541; 104993015; 105067328; 107147810; 109270167; 109563013; 109693368; 22004; 481598; 497015; 500450" "ENSAMEG00000009574; ENSBGRG00000004079; ENSBIXG00000019614; ENSBIXG00005009306; ENSBTAG00000011424; ENSCAFG00000002086; ENSCAFG00030010468; ENSCAFG00040011963; ENSCCNG00000000211; ENSCGRG00001005345; ENSCHIG00000014590; ENSCWAG00000004599; ENSEASG00005013988; ENSFCAG00000012746; ENSJJAG00000000463; ENSLCNG00005021139; ENSMMMG00000006919; ENSMMNG00015018288; ENSMMSG00000015633; ENSMSIG00000018778; ENSMUSG00000028464; ENSNGAG00000009787; ENSOARG00000011889; ENSPCTG00005019723; ENSPEMG00000017305; ENSPLOG00000014611; ENSPTIG00000007337; ENSRNOG00000016731; ENSRNOG00055016972; ENSRNOG00060003924; ENSRNOG00065009935; ENSSDAG00000021965; ENSSSCG00000005316; ENSSSCG00005046181; ENSSSCG00015006618; ENSSSCG00030049128; ENSSSCG00045014334; ENSSSCG00055011546; ENSSSCG00060020399; ENSSSCG00065049969; ENSSSCG00070027162; ENSSTOG00000005060; ENSTSYG00000032896; ENSUPAG00010017829; ENSVVUG00000023722" "LOC101353128; LOC111145591; TLN1; Tpm2; TPM2" "A0A068BCW7; A0A1U7TMR0; A0A1U8CH40; A0A250XXQ4; A0A287D3T9; A0A2U3VCL3; A0A2U3YUX6; A0A2Y9DCZ9; A0A2Y9ETA1; A0A2Y9J9C1; A0A2Y9QKP5; A0A340X3W8; A0A341CVS1; A0A384CEW4; A0A3Q7MNR9; A0A3Q7TH41; A0A452EN00; A0A480T5S2; A0A485PDX6; A0A4W2CPF2; A0A4X1VW25; A0A5E4A5W7; A0A5G2QMK3; A0A5N3WLQ3; A0A5N3X4X0; A0A667I0K7; A0A6I9I5W3; A0A6J0DVY9; A0A6J0WJ96; A0A6J1XS23; A0A6J2EMR2; A0A6J3RJC1; A0A6P3E836; A0A6P3HYL3; A0A6P5C7T4; A0A6P5PJW6; A0A8B6YIA5; A0A8B7AAV4; A0A8B9WKC4; A0A8C0N098; A0A8C2LHJ6; A0A8C3VSF0; A0A8C4M4N0; A0A8C5JXI0; A0A8C5Z1J8; A0A8C6FC53; A0A8C6FP91; A0A8C6HI82; A0A8C6QP27; A0A8C8XN44; A0A8C9JQT4; A0A8C9QML5; A0A8D1QBT1; A0A8D2I2M6; A0A8M1MSU2; A0A8U0MM24; A0A9V1FVP9; A0A9W3EM47; A0AA41MDA9; bbis:104993015; biu:109563013; bta:497015; ccan:109693368; cfr:102505904; E2RAH4; G1LSK6; lww:102737237; M3WH86; mmu:22004; mpuf:101678214; ngi:103741541; oas:101114931; oro:101382361; P02560; P06395; P46901; P58774; P58775; P58776; ptg:102952315; Q3SX28; Q5KR48; rno:500450; tmu:101353128; vpc:102542609; W5PQL7" "Striated Muscle Contraction; Smooth Muscle Contraction; Smooth Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Smooth Muscle Contraction" "Striated muscle contraction; Striated muscle contraction" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "57.847" "14" "11" "13" "11" "875" "98.5" "6.73" "51.13" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "Amino acids regulate mTORC1" "" "1" "0" "1.037" "1.019" "1.057" "1.003" "1.069" "1.009" "1.009" "0.930" "0.743" "962.6" "998.5" "980.7" "1017.9" "965.4" "1028.6" "971.2" "971.4" "895.1" "715.1" "" "" "" "" "" "" "" "" "" "" "853.6" "827.1" "855.7" "761.2" "805.0" "944.9" "820.8" "802.9" "820.9" "715.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "57.837" "33" "10" "14" "10" "313" "35.1" "7.69" "49.79" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "1.005" "1.055" "1.015" "1.031" "1.062" "1.021" "1.018" "1.000" "0.734" "1921.1" "1930.6" "2026.7" "1949.3" "1981.1" "2039.6" "1961.1" "1954.8" "1922.0" "1410.9" "" "" "" "" "" "" "" "" "" "" "1703.6" "1599.2" "1768.4" "1457.9" "1652.0" "1873.6" "1657.5" "1615.8" "1762.7" "1410.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516150800733119915" "False" "High" "IsMasterProtein" "P55011" "Solute carrier family 12 member 2 OS=Homo sapiens OX=9606 GN=SLC12A2 PE=1 SV=1" "0.000" "False" "57.743" "7" "5" "8" "5" "1212" "131.4" "6.40" "41.02" "5" "cell-cell signaling;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522, Pf08403" "6558" "ENSG00000064651" "SLC12A2" "hsa:6558; P55011; Q8N713; Q8WWH7" "Cation-coupled Chloride cotransporters" "Polycystic kidney disease pathway" "2" "0" "1.072" "0.983" "1.059" "1.028" "0.942" "1.004" "0.992" "0.975" "0.711" "935.6" "1002.6" "919.5" "991.2" "962.1" "881.1" "939.8" "928.1" "912.5" "665.3" "" "" "" "" "" "" "" "" "" "" "829.6" "830.5" "802.3" "741.3" "802.3" "809.4" "794.3" "767.2" "836.9" "665.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.000" "False" "57.727" "66" "6" "12" "6" "137" "14.5" "8.68" "47.09" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "Threonine catabolism" "" "1" "0" "1.017" "1.100" "1.114" "1.107" "1.196" "1.055" "1.087" "1.164" "0.554" "1298.3" "1320.7" "1428.2" "1446.1" "1437.7" "1552.4" "1369.9" "1410.7" "1511.9" "719.0" "" "" "" "" "" "" "" "" "" "" "1151.3" "1094.0" "1246.2" "1081.5" "1198.8" "1426.0" "1157.8" "1166.0" "1386.6" "719.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8904894331141024633" "False" "High" "IsMasterProtein" "Q04726" "Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2" "0.000" "False" "57.656" "18" "13" "16" "7" "772" "83.4" "7.20" "56.58" "13" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7090" "ENSG00000140332" "TLE3" "B4DPT0; E9PD64; F8W964; hsa:7090; Q04726; Q6PI57; Q8IVV6; Q8WVR2; Q9HCM5" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent gene expression; Repression of WNT target genes" "White fat cell differentiation" "5" "4" "0.989" "0.928" "0.955" "0.901" "0.916" "0.871" "0.906" "0.876" "0.644" "1957.1" "1935.0" "1815.3" "1868.9" "1764.1" "1791.8" "1704.1" "1772.2" "1714.8" "1260.2" "" "" "" "" "" "" "" "" "" "" "1735.5" "1602.9" "1583.9" "1397.7" "1471.0" "1646.0" "1440.3" "1464.8" "1572.7" "1260.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "57.651" "9" "14" "17" "6" "1585" "176.5" "5.38" "60.58" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "ISG15 antiviral mechanism" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "3" "1" "0.997" "0.923" "0.961" "0.905" "0.932" "0.944" "0.762" "0.881" "2.825" "808.7" "806.6" "746.3" "776.9" "732.1" "754.1" "763.5" "616.0" "712.5" "2284.2" "" "" "" "" "" "" "" "" "" "" "717.2" "668.2" "651.2" "581.0" "610.4" "692.7" "645.3" "509.2" "653.4" "2284.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022881073250375863" "False" "High" "IsMasterProtein" "P16455" "Methylated-DNA--protein-cysteine methyltransferase OS=Homo sapiens OX=9606 GN=MGMT PE=1 SV=1" "0.000" "False" "57.640" "40" "7" "14" "7" "207" "21.6" "8.10" "60.64" "7" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01035, Pf02870" "4255" "ENSG00000170430" "MGMT" "P16455; Q5VY78" "MGMT-mediated DNA damage reversal" "Direct reversal repair; DNA repair pathways, full network; p53 transcriptional gene network" "4" "0" "0.967" "1.030" "0.974" "1.002" "1.036" "0.918" "0.966" "0.928" "0.661" "1837.5" "1777.3" "1892.3" "1790.1" "1841.1" "1903.1" "1686.7" "1775.4" "1705.9" "1213.8" "" "" "" "" "" "" "" "" "" "" "1629.5" "1472.2" "1651.1" "1338.8" "1535.2" "1748.2" "1425.5" "1467.5" "1564.5" "1213.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386801928701098306" "False" "High" "IsMasterProtein" "Q6ULP2" "Aftiphilin OS=Homo sapiens OX=9606 GN=AFTPH PE=1 SV=3" "0.000" "False" "57.639" "13" "10" "13" "10" "936" "102.1" "4.54" "47.28" "10" "transport" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15045" "54812" "ENSG00000119844" "AFTPH" "D6W5E9; hsa:54812; Q6ULP2; Q6ZM66; Q86VW3; Q8TCF3; Q9H7E3; Q9HAB9; Q9NXS4" "" "" "0" "0" "1.028" "1.007" "1.102" "0.995" "0.935" "0.989" "0.943" "0.850" "1.125" "1055.2" "1084.9" "1062.5" "1162.5" "1049.8" "986.6" "1043.3" "995.0" "897.0" "1187.5" "" "" "" "" "" "" "" "" "" "" "935.7" "898.7" "927.1" "869.4" "875.4" "906.3" "881.8" "822.4" "822.7" "1187.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "57.638" "20" "7" "15" "7" "403" "44.5" "7.03" "60.85" "7" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.011" "0.995" "1.110" "1.062" "0.987" "1.097" "1.138" "0.971" "0.765" "896.8" "906.9" "892.0" "995.6" "952.1" "884.7" "983.6" "1020.4" "870.9" "686.3" "" "" "" "" "" "" "" "" "" "" "795.3" "751.2" "778.4" "744.6" "793.9" "812.7" "831.3" "843.4" "798.8" "686.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3796638279955905475" "False" "High" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.000" "False" "57.634" "31" "11" "14" "11" "417" "46.3" "7.37" "56.39" "11" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "" "5" "0" "1.019" "0.985" "0.978" "1.005" "1.006" "0.979" "1.017" "0.999" "0.732" "1725.9" "1759.0" "1700.3" "1688.6" "1734.3" "1736.6" "1688.8" "1755.2" "1725.0" "1263.8" "" "" "" "" "" "" "" "" "" "" "1530.5" "1457.1" "1483.6" "1262.8" "1446.2" "1595.2" "1427.3" "1450.8" "1582.0" "1263.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "57.585" "40" "5" "22" "5" "103" "11.4" "11.36" "82.17" "5" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of chromatin organization proteins; Processing of DNA double-strand break ends; HCMV Late Events; Amyloid fiber formation; Meiotic synapsis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "52" "0" "0.740" "0.726" "0.661" "0.729" "0.653" "0.620" "0.614" "0.668" "0.552" "4163.5" "3083.0" "3022.9" "2752.9" "3033.7" "2720.8" "2583.1" "2555.5" "2782.4" "2296.6" "" "" "" "" "" "" "" "" "" "" "3692.1" "2553.8" "2637.6" "2058.8" "2529.7" "2499.4" "2183.1" "2112.3" "2551.9" "2296.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "57.573" "41" "9" "22" "9" "180" "20.3" "4.96" "68.57" "9" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "" "2" "0" "1.040" "0.988" "1.000" "1.039" "1.039" "1.055" "1.030" "0.956" "0.590" "1645.0" "1710.1" "1626.0" "1645.5" "1709.4" "1709.4" "1735.1" "1694.1" "1573.1" "970.3" "" "" "" "" "" "" "" "" "" "" "1458.8" "1416.6" "1418.7" "1230.6" "1425.4" "1570.3" "1466.4" "1400.3" "1442.8" "970.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "57.534" "40" "6" "15" "5" "172" "19.5" "6.34" "52.34" "6" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "0.958" "1.013" "0.963" "0.986" "1.040" "0.997" "1.029" "0.890" "0.478" "1858.0" "1780.0" "1882.7" "1790.1" "1832.1" "1933.1" "1851.6" "1911.4" "1652.9" "887.4" "" "" "" "" "" "" "" "" "" "" "1647.7" "1474.5" "1642.7" "1338.8" "1527.7" "1775.7" "1564.9" "1579.9" "1515.9" "887.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.000" "False" "57.492" "68" "7" "13" "7" "111" "12.0" "9.83" "54.26" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "Termination of translesion DNA synthesis" "" "1" "0" "0.985" "1.025" "1.056" "1.138" "1.071" "1.788" "1.956" "1.898" "0.624" "1562.8" "1539.0" "1601.4" "1649.9" "1778.0" "1673.3" "2794.0" "3056.2" "2966.2" "976.0" "" "" "" "" "" "" "" "" "" "" "1385.9" "1274.8" "1397.3" "1233.9" "1482.6" "1537.1" "2361.4" "2526.2" "2720.4" "976.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1694766210594215776" "False" "High" "IsMasterProtein" "P10301" "Ras-related protein R-Ras OS=Homo sapiens OX=9606 GN=RRAS PE=1 SV=1" "0.000" "False" "57.458" "21" "4" "16" "2" "218" "23.5" "6.93" "69.31" "4" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00071" "6237" "ENSG00000126458" "RRAS" "hsa:6237; P10301; Q6FH12" "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema4D mediated inhibition of cell attachment and migration" "G protein signaling pathways; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; MAPK cascade; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGFR tyrosine kinase inhibitor resistance; Angiotensin II receptor type 1 pathway; Regulation of actin cytoskeleton" "13" "0" "1.081" "1.048" "1.019" "1.104" "1.009" "1.133" "1.034" "1.084" "0.601" "160.8" "173.8" "168.6" "163.8" "177.5" "162.2" "182.1" "166.3" "174.3" "96.7" "" "" "" "" "" "" "" "" "" "" "142.6" "144.0" "147.1" "122.5" "148.0" "149.0" "153.9" "137.4" "159.8" "96.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7392710609967527407" "False" "High" "IsMasterProtein" "Q96BH1" "E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1" "0.000" "False" "57.448" "30" "11" "16" "11" "459" "51.2" "6.54" "59.33" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf05773, Pf13639" "64320" "ENSG00000163481" "RNF25" "A8K0D6; hsa:64320; Q53HQ5; Q96BH1; Q9H874" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.999" "1.012" "0.974" "0.988" "1.020" "0.956" "0.976" "1.004" "0.726" "1662.3" "1660.6" "1682.7" "1618.7" "1642.4" "1696.0" "1588.7" "1622.7" "1668.6" "1207.4" "" "" "" "" "" "" "" "" "" "" "1474.1" "1375.6" "1468.2" "1210.6" "1369.6" "1558.0" "1342.7" "1341.3" "1530.3" "1207.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.000" "False" "57.326" "18" "7" "8" "7" "571" "60.6" "6.54" "38.94" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Ovarian tumor domain proteases; Negative regulators of DDX58/IFIH1 signaling" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "4" "0" "1.058" "0.987" "1.082" "1.075" "1.030" "1.107" "1.090" "1.080" "0.914" "605.4" "640.8" "597.3" "654.9" "650.9" "623.7" "670.1" "659.8" "654.1" "553.6" "" "" "" "" "" "" "" "" "" "" "536.9" "530.8" "521.2" "489.8" "542.7" "573.0" "566.3" "545.4" "599.9" "553.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "High" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.000" "False" "57.310" "49" "9" "10" "9" "275" "29.6" "8.10" "40.03" "9" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "0.967" "0.984" "1.004" "1.018" "0.974" "1.074" "1.035" "0.953" "1.217" "798.4" "772.5" "785.9" "801.4" "812.9" "777.7" "857.2" "826.7" "761.1" "971.4" "" "" "" "" "" "" "" "" "" "" "708.0" "639.9" "685.8" "599.3" "677.9" "714.4" "724.5" "683.4" "698.1" "971.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "57.296" "20" "11" "14" "7" "579" "62.3" "8.79" "54.32" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "4" "0.983" "0.976" "0.950" "1.056" "0.961" "0.947" "0.940" "0.921" "1.058" "1874.8" "1843.0" "1829.0" "1781.5" "1979.8" "1801.3" "1775.7" "1762.6" "1726.4" "1983.6" "" "" "" "" "" "" "" "" "" "" "1662.6" "1526.6" "1595.9" "1332.3" "1650.9" "1654.7" "1500.8" "1456.9" "1583.4" "1983.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3524975929259860741" "False" "High" "IsMasterProtein" "Q86X27" "Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1" "0.000" "False" "57.257" "19" "10" "13" "10" "583" "65.1" "8.73" "50.34" "10" "signal transduction" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00169, Pf00617" "55103" "ENSG00000116191" "RALGPS2" "B7Z7B1; hsa:55103; Q5T5Z1; Q5VZ67; Q86X27; Q9NW78" "" "" "0" "0" "1.039" "0.975" "1.004" "0.979" "0.975" "0.959" "0.909" "0.968" "1.432" "1647.0" "1710.4" "1606.3" "1653.9" "1613.0" "1606.2" "1579.4" "1497.4" "1594.1" "2358.5" "" "" "" "" "" "" "" "" "" "" "1460.5" "1416.8" "1401.6" "1236.9" "1345.1" "1475.5" "1334.8" "1237.7" "1462.0" "2358.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8914003618785624230" "False" "High" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "0.000" "False" "57.242" "39" "8" "15" "8" "225" "26.1" "5.66" "52.75" "8" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.011" "1.009" "0.988" "0.980" "1.057" "0.996" "0.959" "0.987" "1.458" "1570.9" "1588.0" "1584.6" "1551.7" "1539.5" "1660.6" "1564.0" "1506.7" "1550.4" "2291.1" "" "" "" "" "" "" "" "" "" "" "1393.1" "1315.4" "1382.7" "1160.5" "1283.7" "1525.4" "1321.9" "1245.4" "1421.9" "2291.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107589471447250441" "False" "High" "IsMasterProtein" "Q9NV06" "DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2" "0.000" "False" "57.202" "25" "9" "11" "9" "445" "51.4" "9.19" "42.06" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04158, Pf08662" "25879" "ENSG00000164934" "DCAF13" "hsa:25879; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NV06; Q9NZX3" "Major pathway of rRNA processing in the nucleolus and cytosol; Neddylation; rRNA modification in the nucleus and cytosol" "" "3" "0" "1.005" "0.952" "1.064" "0.978" "0.948" "0.805" "0.763" "0.821" "0.511" "940.9" "945.2" "895.9" "1001.4" "920.1" "892.3" "757.8" "718.0" "772.9" "480.7" "" "" "" "" "" "" "" "" "" "" "834.3" "783.0" "781.7" "748.9" "767.2" "819.7" "640.5" "593.5" "708.8" "480.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6268671224724585393" "False" "High" "IsMasterProtein" "P56945" "Breast cancer anti-estrogen resistance protein 1 OS=Homo sapiens OX=9606 GN=BCAR1 PE=1 SV=2" "0.000" "False" "57.184" "14" "9" "11" "9" "870" "93.3" "5.67" "45.54" "9" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00018, Pf08824, Pf12026" "9564" "ENSG00000050820" "BCAR1" "B3KWD7; B4DEV4; B4DGB5; B4DIW5; B7Z7X7; E9PCL5; E9PCV2; F5GXA2; F5GXV6; F5H7Z0; F8WA69; hsa:9564; P56945; Q6QEF7" "Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; p130Cas linkage to MAPK signaling for integrins" "Integrin-mediated cell adhesion; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; miR-509-3p alteration of YAP1/ECM axis; EGF/EGFR signaling pathway; Gastrin signaling pathway; Regulation of actin cytoskeleton; GDNF signaling; NPHP1 deletion syndrome" "15" "0" "0.987" "0.966" "0.973" "0.959" "0.981" "1.007" "0.855" "0.922" "1.278" "932.1" "920.4" "900.8" "906.8" "894.3" "914.0" "938.7" "797.2" "859.6" "1191.0" "" "" "" "" "" "" "" "" "" "" "826.6" "762.4" "786.0" "678.2" "745.7" "839.6" "793.4" "659.0" "788.4" "1191.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1819125433981479748" "False" "High" "IsMasterProtein" "Q15404" "Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3" "0.000" "False" "57.161" "32" "9" "21" "9" "277" "31.5" "8.65" "66.35" "9" "signal transduction;other biological processes" "cytosol;other cell component" "" "Pf13855" "6251" "ENSG00000148484" "RSU1" "A8KA46; D3DRU3; hsa:6251; Q15404; Q6FI17" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "" "1" "0" "1.026" "0.992" "0.986" "0.993" "1.009" "0.945" "0.961" "0.986" "0.860" "2316.3" "2377.2" "2297.1" "2284.3" "2300.2" "2337.6" "2189.9" "2227.0" "2283.5" "1992.6" "" "" "" "" "" "" "" "" "" "" "2054.1" "1969.2" "2004.3" "1708.4" "1918.1" "2147.3" "1850.8" "1840.8" "2094.3" "1992.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "491541445040481155" "False" "High" "IsMasterProtein" "P02545" "Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1" "0.000" "False" "56.984" "20" "12" "13" "11" "664" "74.1" "7.02" "48.93" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "4000" "ENSG00000160789" "LMNA" "B4DI32; D3DVB0; D6RAQ3; E7EUI9; hsa:4000; P02545; P02546; Q5I6Y4; Q5I6Y6; Q5TCJ2; Q5TCJ3; Q6UYC3; Q969I8; Q96JA2" "Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes" "Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Primary ovarian insufficiency; 7q11.23 distal copy number variation" "14" "0" "0.975" "0.936" "0.958" "0.992" "0.962" "0.972" "0.912" "0.999" "0.716" "633.2" "617.1" "592.4" "606.3" "627.9" "609.4" "615.5" "577.5" "632.7" "453.6" "" "" "" "" "" "" "" "" "" "" "561.5" "511.2" "516.9" "453.4" "523.6" "559.8" "520.2" "477.3" "580.3" "453.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "56.982" "23" "10" "18" "6" "488" "55.3" "5.91" "70.14" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Regulation of TP53 Activity through Acetylation; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "30" "0" "1.025" "1.037" "0.935" "0.931" "0.998" "1.017" "1.005" "1.009" "0.994" "1426.4" "1461.9" "1479.7" "1333.7" "1328.4" "1423.4" "1450.5" "1433.9" "1439.9" "1417.5" "" "" "" "" "" "" "" "" "" "" "1264.9" "1211.0" "1291.2" "997.5" "1107.7" "1307.6" "1225.9" "1185.2" "1320.6" "1417.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965361047709710571" "False" "High" "IsMasterProtein" "Q58FG1" "Putative heat shock protein HSP 90-alpha A4 OS=Homo sapiens OX=9606 GN=HSP90AA4P PE=5 SV=1" "0.000" "False" "56.900" "11" "5" "86" "1" "418" "47.7" "5.19" "319.79" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00183, Pf13589" "" "" "HSP90AA4P" "Q58FG1" "" "" "0" "0" "1.015" "0.880" "0.996" "0.862" "1.085" "1.044" "0.991" "0.741" "1.490" "125.6" "127.5" "110.6" "125.1" "108.3" "136.3" "131.1" "124.5" "93.1" "187.2" "" "" "" "" "" "" "" "" "" "" "111.4" "105.6" "96.5" "93.6" "90.3" "125.2" "110.8" "102.9" "85.4" "187.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869941848494998165" "False" "High" "IsMasterProtein" "O75170" "Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2" "0.000" "False" "56.890" "16" "11" "11" "10" "966" "104.9" "4.87" "44.34" "11" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04499" "9701" "ENSG00000100239" "PPP6R2" "A6PVG3; B7Z7T3; hsa:9701; O75170; Q5U5P3; Q7Z2L2; Q7Z5G5; Q7Z731; Q9UGB9" "" "" "0" "0" "1.036" "0.993" "1.061" "1.035" "0.952" "0.992" "0.984" "0.987" "0.649" "561.7" "581.7" "558.0" "595.7" "581.6" "534.7" "557.1" "552.7" "554.3" "364.8" "" "" "" "" "" "" "" "" "" "" "498.1" "481.8" "486.8" "445.5" "485.0" "491.2" "470.8" "456.9" "508.4" "364.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "56.847" "33" "12" "14" "12" "421" "46.1" "9.99" "55.95" "12" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "1.016" "1.016" "1.026" "0.975" "0.949" "1.086" "1.025" "1.078" "0.915" "988.8" "1004.2" "1005.0" "1014.6" "963.7" "938.2" "1073.9" "1014.0" "1066.0" "904.9" "" "" "" "" "" "" "" "" "" "" "876.9" "831.8" "877.0" "758.8" "803.6" "861.8" "907.6" "838.1" "977.7" "904.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575991461264525713" "False" "High" "IsMasterProtein" "Q99933" "BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4" "0.000" "False" "56.808" "27" "8" "15" "8" "345" "38.8" "7.81" "60.51" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf02179" "573" "ENSG00000107262" "BAG1" "hsa:573; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q99933; Q9Y2V4" "Regulation of HSF1-mediated heat shock response" "Androgen receptor signaling pathway" "2" "0" "0.991" "1.012" "1.067" "0.991" "0.996" "1.022" "0.965" "1.002" "0.554" "1213.8" "1203.2" "1228.4" "1295.1" "1202.8" "1208.4" "1240.8" "1171.9" "1216.7" "673.0" "" "" "" "" "" "" "" "" "" "" "1076.4" "996.6" "1071.8" "968.5" "1003.0" "1110.1" "1048.7" "968.7" "1115.9" "673.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "56.779" "68" "10" "14" "10" "160" "18.3" "6.30" "53.88" "10" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "11" "0" "0.974" "0.907" "0.947" "0.916" "0.972" "0.933" "0.937" "0.928" "0.513" "1378.8" "1342.4" "1251.1" "1306.0" "1262.6" "1340.4" "1287.1" "1291.6" "1280.0" "706.8" "" "" "" "" "" "" "" "" "" "" "1222.7" "1112.0" "1091.6" "976.7" "1052.9" "1231.3" "1087.8" "1067.6" "1174.0" "706.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4707319533501773453" "False" "High" "IsMasterProtein" "O95260" "Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2" "0.000" "False" "56.752" "26" "11" "17" "11" "518" "59.1" "7.93" "66.95" "11" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04376, Pf04377" "11101" "ENSG00000107669" "ATE1" "hsa:11101; O95260; O95261; Q5SQQ3; Q8WW04" "" "" "0" "0" "1.101" "1.021" "0.938" "0.962" "0.979" "0.832" "0.843" "0.846" "0.938" "2840.8" "3128.9" "2899.3" "2663.8" "2731.8" "2781.3" "2363.5" "2393.6" "2403.2" "2665.1" "" "" "" "" "" "" "" "" "" "" "2519.2" "2591.8" "2529.8" "1992.2" "2278.0" "2555.0" "1997.5" "1978.5" "2204.0" "2665.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "56.743" "48" "12" "26" "12" "249" "28.4" "9.23" "93.17" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "Eukaryotic transcription initiation" "33" "0" "0.967" "0.987" "0.920" "0.931" "0.946" "0.884" "0.930" "0.938" "0.690" "4109.4" "3971.8" "4057.6" "3780.7" "3826.0" "3886.7" "3633.2" "3823.1" "3856.3" "2835.0" "" "" "" "" "" "" "" "" "" "" "3644.1" "3290.1" "3540.4" "2827.4" "3190.3" "3570.4" "3070.6" "3160.1" "3536.7" "2835.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "56.670" "24" "13" "20" "13" "475" "51.8" "7.85" "71.83" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.975" "0.929" "1.038" "0.981" "0.959" "0.967" "0.929" "0.790" "0.424" "2994.7" "2918.7" "2782.2" "3108.7" "2937.9" "2873.1" "2896.6" "2781.7" "2366.0" "1271.1" "" "" "" "" "" "" "" "" "" "" "2655.6" "2417.7" "2427.6" "2324.9" "2449.8" "2639.3" "2448.1" "2299.3" "2169.9" "1271.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "High" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.000" "False" "56.665" "37" "10" "15" "10" "307" "33.9" "6.29" "51.70" "10" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "0.968" "1.023" "0.932" "0.885" "0.924" "0.996" "1.014" "1.121" "2.874" "963.3" "932.5" "985.4" "898.0" "852.7" "889.6" "959.3" "976.9" "1079.7" "2768.1" "" "" "" "" "" "" "" "" "" "" "854.2" "772.4" "859.8" "671.6" "711.0" "817.2" "810.8" "807.5" "990.2" "2768.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "56.516" "29" "8" "10" "8" "327" "35.6" "7.97" "39.80" "8" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "" "22q11.2 copy number variation syndrome" "1" "0" "1.048" "0.933" "1.094" "1.013" "0.917" "0.862" "0.906" "0.847" "0.496" "958.9" "1004.5" "894.9" "1048.8" "971.6" "879.6" "826.3" "868.6" "811.8" "476.1" "" "" "" "" "" "" "" "" "" "" "850.3" "832.1" "780.8" "784.4" "810.2" "808.0" "698.3" "718.0" "744.5" "476.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.000" "False" "56.473" "16" "8" "18" "8" "599" "60.9" "9.33" "67.43" "8" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "1.027" "0.970" "1.012" "1.015" "1.045" "1.037" "1.007" "1.052" "0.677" "869.8" "893.3" "843.3" "880.6" "883.2" "909.4" "902.2" "875.8" "915.1" "589.2" "" "" "" "" "" "" "" "" "" "" "771.3" "740.0" "735.8" "658.6" "736.5" "835.3" "762.5" "723.9" "839.2" "589.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.000" "False" "56.401" "35" "4" "7" "4" "213" "23.1" "8.51" "39.45" "4" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "0.995" "0.953" "0.973" "0.984" "1.060" "0.963" "1.044" "1.035" "0.468" "680.2" "676.8" "648.3" "661.9" "669.5" "720.7" "655.2" "710.3" "704.3" "318.3" "" "" "" "" "" "" "" "" "" "" "603.2" "560.6" "565.6" "495.0" "558.3" "662.1" "553.7" "587.1" "646.0" "318.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-367492356169293166" "False" "High" "IsMasterProtein" "Q12965" "Unconventional myosin-Ie OS=Homo sapiens OX=9606 GN=MYO1E PE=1 SV=2" "0.000" "False" "56.385" "12" "13" "14" "13" "1108" "127.0" "8.92" "48.85" "13" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00063, Pf06017" "4643" "ENSG00000157483" "MYO1E" "hsa:4643; Q12965; Q14778" "" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "2" "0" "1.035" "0.934" "1.244" "1.077" "0.953" "1.128" "0.409" "1.052" "12.214" "586.1" "606.5" "547.5" "729.3" "631.2" "558.6" "660.8" "239.6" "616.6" "7157.9" "" "" "" "" "" "" "" "" "" "" "519.7" "502.4" "477.7" "545.4" "526.3" "513.2" "558.5" "198.0" "565.5" "7157.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "56.380" "27" "14" "19" "14" "514" "57.6" "9.42" "56.95" "14" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "1.040" "1.046" "1.176" "1.028" "1.065" "0.990" "1.059" "1.068" "0.922" "1246.6" "1297.0" "1303.9" "1466.3" "1281.1" "1327.6" "1233.6" "1320.6" "1330.9" "1149.1" "" "" "" "" "" "" "" "" "" "" "1105.5" "1074.4" "1137.7" "1096.6" "1068.3" "1219.6" "1042.6" "1091.5" "1220.7" "1149.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6367954742648610470" "False" "High" "IsMasterProtein" "Cont_E1BJK2" "Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB1 PE=3 SV=1" "0.000" "True" "56.308" "10" "7" "88" "1" "450" "50.0" "5.11" "234.41" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "541271" "ENSBIXG00000020524; ENSBTAG00000018785" "TUBB1" "A0A4W2CSS1; bta:541271; E1BJK2" "" "Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway" "2" "0" "1.078" "0.994" "1.211" "0.863" "0.955" "1.112" "1.052" "0.865" "0.511" "173.0" "186.4" "171.9" "209.5" "149.3" "165.2" "192.3" "181.9" "149.6" "88.4" "" "" "" "" "" "" "" "" "" "" "153.4" "154.4" "150.0" "156.7" "124.5" "151.7" "162.5" "150.4" "137.2" "88.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.000" "False" "56.269" "21" "14" "15" "14" "701" "80.6" "7.56" "52.33" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "1.002" "1.029" "0.893" "0.970" "0.988" "0.938" "0.945" "1.008" "1.325" "1510.5" "1512.8" "1554.2" "1348.7" "1465.5" "1492.7" "1416.1" "1427.1" "1522.7" "2002.0" "" "" "" "" "" "" "" "" "" "" "1339.4" "1253.1" "1356.1" "1008.6" "1222.0" "1371.2" "1196.8" "1179.6" "1396.5" "2002.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "56.228" "40" "10" "16" "10" "272" "31.4" "5.91" "47.61" "10" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "" "Ciliary landscape" "1" "0" "0.977" "0.977" "0.890" "0.873" "0.932" "1.017" "0.922" "1.008" "2.076" "969.1" "946.9" "947.2" "863.0" "846.2" "903.7" "985.1" "893.3" "977.3" "2011.5" "" "" "" "" "" "" "" "" "" "" "859.4" "784.4" "826.5" "645.4" "705.6" "830.1" "832.5" "738.4" "896.3" "2011.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5885544299660582153" "False" "High" "IsMasterProtein" "P19971" "Thymidine phosphorylase OS=Homo sapiens OX=9606 GN=TYMP PE=1 SV=2" "0.000" "False" "56.187" "21" "8" "9" "8" "482" "49.9" "5.53" "40.54" "8" "cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00591, Pf02885, Pf07831" "1890" "ENSG00000025708" "TYMP" "A8MW15; H9KVA0; hsa:1890; P19971; Q13390; Q8WVB7" "Pyrimidine salvage; Pyrimidine catabolism" "Fluoropyrimidine activity; Bladder cancer; Pyrimidine metabolism" "5" "0" "1.247" "1.038" "1.149" "1.370" "1.174" "1.079" "1.059" "0.992" "0.600" "1133.3" "1412.8" "1176.8" "1302.6" "1552.2" "1330.1" "1222.5" "1200.2" "1124.3" "680.2" "" "" "" "" "" "" "" "" "" "" "1005.0" "1170.3" "1026.8" "974.1" "1294.3" "1221.9" "1033.2" "992.1" "1031.2" "680.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062599375234318027" "False" "High" "IsMasterProtein" "Q02447" "Transcription factor Sp3 OS=Homo sapiens OX=9606 GN=SP3 PE=1 SV=3" "0.000" "False" "56.183" "13" "7" "11" "7" "781" "81.9" "5.26" "46.82" "7" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6670" "ENSG00000172845" "SP3" "A0AVL9; B4E2B7; hsa:6670; Q02447; Q69B26; Q69B27; Q8TD56; Q8WWU4; Q9BQR1" "SUMOylation of transcription factors" "Selenium metabolism and selenoproteins; MECP2 and associated Rett syndrome; Non-genomic actions of 1,25 dihydroxyvitamin D3; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "0.938" "1.081" "0.952" "0.904" "0.918" "1.006" "0.999" "1.045" "0.868" "1340.3" "1256.7" "1449.4" "1275.3" "1211.0" "1230.4" "1348.0" "1338.7" "1401.3" "1163.0" "" "" "" "" "" "" "" "" "" "" "1188.6" "1041.0" "1264.7" "953.8" "1009.8" "1130.3" "1139.3" "1106.5" "1285.1" "1163.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "56.157" "16" "14" "15" "14" "907" "102.3" "7.14" "49.23" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "ISG15 antiviral mechanism" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "4" "0" "0.929" "0.960" "1.074" "0.921" "0.941" "0.939" "0.510" "0.940" "8.224" "707.7" "657.7" "679.1" "760.0" "651.9" "665.9" "664.8" "360.7" "665.4" "5820.2" "" "" "" "" "" "" "" "" "" "" "627.6" "544.8" "592.5" "568.4" "543.6" "611.7" "561.8" "298.2" "610.3" "5820.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "56.155" "12" "16" "17" "15" "1357" "156.2" "5.64" "56.12" "16" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHO GTPases activate KTN1" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "11" "0" "0.971" "0.995" "0.898" "0.914" "0.884" "0.811" "0.850" "0.903" "1.034" "1132.0" "1099.4" "1125.8" "1016.5" "1035.1" "1000.5" "918.4" "962.5" "1022.3" "1170.5" "" "" "" "" "" "" "" "" "" "" "1003.9" "910.7" "982.3" "760.2" "863.2" "919.0" "776.2" "795.6" "937.6" "1170.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "56.145" "24" "11" "13" "10" "523" "58.7" "6.67" "48.30" "11" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "1.020" "0.968" "1.015" "0.985" "0.978" "1.015" "0.826" "0.992" "4.111" "1251.1" "1275.5" "1210.8" "1270.4" "1232.3" "1223.3" "1269.9" "1033.3" "1241.3" "5142.8" "" "" "" "" "" "" "" "" "" "" "1109.5" "1056.6" "1056.5" "950.1" "1027.6" "1123.7" "1073.2" "854.1" "1138.5" "5142.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.000" "False" "56.111" "19" "7" "10" "6" "479" "52.6" "5.05" "44.97" "7" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "MAPK signaling pathway" "4" "0" "0.990" "0.909" "1.016" "1.033" "0.979" "0.874" "0.924" "0.893" "0.920" "686.4" "679.4" "623.8" "697.2" "709.1" "672.3" "599.7" "634.2" "612.9" "631.3" "" "" "" "" "" "" "" "" "" "" "608.7" "562.8" "544.3" "521.4" "591.3" "617.6" "506.8" "524.2" "562.2" "631.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4994086141420822230" "False" "High" "IsMasterProtein" "P02794" "Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2" "0.000" "False" "56.075" "45" "7" "15" "7" "183" "21.2" "5.55" "55.68" "7" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2495" "ENSG00000167996" "FTH1" "B3KNR5; hsa:2495; P02794; Q3KRA8; Q3SWW1" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Iron metabolism disorders" "9" "0" "1.026" "0.936" "0.994" "1.036" "0.994" "0.974" "1.001" "0.991" "0.653" "1516.0" "1554.8" "1419.1" "1506.3" "1570.5" "1507.0" "1476.1" "1517.4" "1502.1" "989.6" "" "" "" "" "" "" "" "" "" "" "1344.4" "1287.9" "1238.2" "1126.5" "1309.6" "1384.3" "1247.5" "1254.2" "1377.6" "989.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "56.072" "51" "3" "17" "3" "87" "10.0" "6.57" "71.55" "3" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Mitochondrial Fatty Acid Beta-Oxidation" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "6" "0" "0.949" "0.987" "0.933" "1.002" "1.035" "0.961" "1.027" "0.994" "0.492" "3059.2" "2902.0" "3018.0" "2852.8" "3064.0" "3165.2" "2940.6" "3140.5" "3041.9" "1506.3" "" "" "" "" "" "" "" "" "" "" "2712.9" "2403.9" "2633.4" "2133.5" "2554.9" "2907.6" "2485.3" "2595.9" "2789.9" "1506.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088997935077204775" "False" "High" "IsMasterProtein" "Q03393" "6-pyruvoyl tetrahydrobiopterin synthase OS=Homo sapiens OX=9606 GN=PTS PE=1 SV=1" "0.000" "False" "56.022" "56" "7" "18" "7" "145" "16.4" "6.68" "71.32" "7" "other metabolic processes;developmental processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01242" "5805" "ENSG00000150787" "PTS" "B0YJ87; hsa:5805; Q03393; Q8WVG8" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "1" "0" "0.990" "1.007" "0.984" "1.028" "0.962" "1.031" "1.080" "1.038" "0.617" "2998.6" "2968.1" "3018.9" "2951.4" "3081.4" "2884.8" "3091.5" "3239.2" "3111.9" "1851.1" "" "" "" "" "" "" "" "" "" "" "2659.1" "2458.6" "2634.2" "2207.3" "2569.5" "2650.0" "2612.8" "2677.4" "2854.0" "1851.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.000" "False" "55.989" "13" "13" "19" "11" "975" "113.6" "5.94" "58.64" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "ATM signaling in development and disease" "3" "2" "0.970" "0.813" "0.997" "0.877" "0.860" "0.905" "0.647" "0.866" "5.466" "960.8" "932.2" "781.3" "958.3" "842.4" "826.2" "869.5" "621.6" "832.5" "5251.7" "" "" "" "" "" "" "" "" "" "" "852.1" "772.2" "681.7" "716.7" "702.5" "758.9" "734.8" "513.8" "763.5" "5251.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-313217822058437387" "False" "High" "IsMasterProtein" "P55789" "FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2" "0.000" "False" "55.974" "34" "7" "13" "7" "205" "23.4" "7.62" "49.33" "7" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf04777" "2671" "ENSG00000127554; ENSG00000291944" "GFER" "hsa:2671; P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40" "Mitochondrial protein import" "" "1" "0" "0.957" "0.956" "1.005" "0.974" "1.006" "0.946" "1.015" "1.001" "0.367" "891.4" "853.3" "852.5" "895.8" "868.1" "896.8" "843.4" "905.1" "892.6" "327.4" "" "" "" "" "" "" "" "" "" "" "790.5" "706.8" "743.8" "670.0" "723.9" "823.9" "712.8" "748.1" "818.7" "327.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "55.963" "58" "10" "27" "9" "131" "15.5" "8.29" "97.06" "10" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "0.954" "0.948" "0.968" "0.946" "0.978" "0.918" "0.951" "0.900" "0.441" "4426.2" "4224.0" "4197.9" "4286.7" "4189.1" "4328.9" "4062.0" "4210.2" "3984.4" "1951.1" "" "" "" "" "" "" "" "" "" "" "3925.0" "3499.0" "3662.8" "3205.9" "3493.1" "3976.6" "3433.0" "3480.1" "3654.2" "1951.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159799509992601123" "False" "High" "IsMasterProtein" "Q96FK6" "WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=1 SV=1" "0.000" "False" "55.959" "25" "8" "11" "8" "387" "43.2" "6.13" "46.76" "8" "developmental processes" "" "" "Pf00400" "112840" "ENSG00000140006" "WDR89" "hsa:112840; Q96FK6" "" "" "0" "0" "0.980" "1.038" "1.012" "0.982" "1.009" "1.004" "1.080" "1.004" "0.297" "1307.5" "1281.4" "1357.6" "1323.4" "1283.6" "1318.8" "1312.6" "1411.9" "1312.6" "388.4" "" "" "" "" "" "" "" "" "" "" "1159.5" "1061.5" "1184.6" "989.7" "1070.3" "1211.5" "1109.3" "1167.0" "1203.8" "388.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "55.907" "19" "10" "14" "10" "564" "62.2" "8.34" "51.23" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.025" "1.011" "0.983" "1.037" "1.077" "1.030" "0.979" "0.971" "0.454" "1935.1" "1983.4" "1955.9" "1901.8" "2007.0" "2083.9" "1993.5" "1894.2" "1879.7" "879.1" "" "" "" "" "" "" "" "" "" "" "1716.0" "1642.9" "1706.6" "1422.3" "1673.5" "1914.3" "1684.8" "1565.7" "1724.0" "879.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "55.867" "31" "10" "21" "10" "388" "41.8" "8.90" "73.16" "10" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "" "Adipogenesis" "1" "0" "0.954" "1.005" "0.965" "1.016" "1.018" "0.963" "0.957" "1.004" "0.790" "1746.6" "1666.6" "1754.9" "1685.1" "1774.4" "1777.4" "1682.6" "1672.3" "1754.3" "1380.6" "" "" "" "" "" "" "" "" "" "" "1548.8" "1380.6" "1531.3" "1260.2" "1479.6" "1632.8" "1422.1" "1382.3" "1608.9" "1380.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "55.740" "45" "8" "15" "8" "208" "24.2" "10.32" "58.68" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.071" "1.105" "1.150" "1.120" "0.880" "1.012" "0.998" "1.144" "2.791" "1501.0" "1608.1" "1659.0" "1726.5" "1681.5" "1321.5" "1518.6" "1498.3" "1716.9" "4189.8" "" "" "" "" "" "" "" "" "" "" "1331.0" "1332.1" "1447.5" "1291.2" "1402.1" "1213.9" "1283.4" "1238.5" "1574.7" "4189.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157541479094675987" "False" "High" "IsMasterProtein" "Q96AB3" "Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1" "0.000" "False" "55.726" "28" "4" "10" "4" "205" "22.3" "7.77" "44.83" "4" "other biological processes" "nucleus;other cell component" "" "Pf00857" "79763" "ENSG00000063241" "ISOC2" "hsa:79763; Q6ZN91; Q96AB3; Q9H5G0" "" "" "0" "0" "1.088" "1.189" "1.218" "1.201" "1.139" "1.196" "1.157" "1.016" "0.484" "826.2" "898.6" "982.1" "1006.6" "992.2" "941.2" "988.5" "956.0" "839.7" "400.2" "" "" "" "" "" "" "" "" "" "" "732.7" "744.3" "856.9" "752.8" "827.4" "864.6" "835.4" "790.2" "770.1" "400.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "55.612" "22" "8" "11" "8" "387" "44.7" "5.60" "42.92" "8" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "1.105" "0.868" "0.963" "0.993" "0.991" "0.929" "0.489" "0.916" "7.724" "534.2" "590.4" "463.9" "514.3" "530.5" "529.4" "496.2" "261.3" "489.2" "4126.6" "" "" "" "" "" "" "" "" "" "" "473.7" "489.1" "404.8" "384.6" "442.3" "486.3" "419.4" "215.9" "448.7" "4126.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "High" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.000" "False" "55.605" "18" "7" "22" "7" "445" "46.7" "5.83" "73.16" "7" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "1.029" "0.987" "0.957" "1.003" "0.942" "0.955" "0.965" "0.969" "0.671" "2258.4" "2323.9" "2228.7" "2160.6" "2265.1" "2127.5" "2157.2" "2180.3" "2187.6" "1515.0" "" "" "" "" "" "" "" "" "" "" "2002.7" "1925.0" "1944.7" "1615.8" "1888.8" "1954.3" "1823.2" "1802.2" "2006.3" "1515.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "55.503" "7" "15" "16" "13" "3224" "358.0" "6.20" "55.31" "15" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Signaling by ALK fusions and activated point mutants" "" "35" "1" "0.986" "0.960" "0.953" "0.975" "1.035" "0.988" "0.832" "0.972" "3.044" "1184.1" "1167.9" "1136.8" "1129.0" "1153.9" "1225.1" "1170.0" "985.1" "1151.4" "3604.2" "" "" "" "" "" "" "" "" "" "" "1050.0" "967.5" "991.9" "844.3" "962.2" "1125.4" "988.8" "814.3" "1056.0" "3604.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "55.489" "46" "7" "13" "7" "146" "17.2" "6.11" "51.63" "7" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "TAR syndrome" "7" "0" "1.016" "1.122" "0.818" "0.940" "1.038" "0.893" "0.949" "0.968" "1.101" "1927.4" "1957.3" "2162.4" "1576.3" "1812.0" "2000.7" "1720.5" "1830.0" "1865.6" "2121.5" "" "" "" "" "" "" "" "" "" "" "1709.2" "1621.3" "1886.8" "1178.8" "1510.9" "1837.9" "1454.1" "1512.6" "1711.0" "2121.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "55.486" "20" "8" "10" "8" "548" "63.9" "6.05" "41.90" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "0.976" "0.912" "1.010" "1.005" "1.052" "0.995" "0.572" "0.971" "7.954" "404.2" "394.4" "368.5" "408.4" "406.1" "425.1" "402.2" "231.4" "392.6" "3215.0" "" "" "" "" "" "" "" "" "" "" "358.5" "326.7" "321.5" "305.4" "338.6" "390.5" "339.9" "191.3" "360.0" "3215.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6270565792586481652" "False" "High" "IsMasterProtein" "Q9UHY7" "Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1" "0.000" "False" "55.367" "27" "5" "7" "5" "261" "28.9" "4.78" "35.52" "5" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00702" "58478" "ENSG00000145293" "ENOPH1" "hsa:58478; Q7Z4C5; Q9BVC2; Q9UHY7" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "1.028" "0.939" "0.922" "0.921" "0.935" "0.838" "0.633" "0.780" "4.019" "411.4" "422.8" "386.2" "379.3" "378.8" "384.7" "344.9" "260.4" "320.8" "1653.7" "" "" "" "" "" "" "" "" "" "" "364.9" "350.2" "337.0" "283.7" "315.9" "353.3" "291.5" "215.2" "294.3" "1653.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "55.177" "53" "6" "23" "6" "132" "14.5" "7.21" "90.10" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.001" "1.064" "0.878" "1.092" "1.138" "0.973" "1.024" "0.983" "0.636" "3505.4" "3510.0" "3728.8" "3078.3" "3827.1" "3990.6" "3410.8" "3588.2" "3444.3" "2229.3" "" "" "" "" "" "" "" "" "" "" "3108.6" "2907.5" "3253.6" "2302.2" "3191.2" "3665.8" "2882.7" "2965.9" "3158.9" "2229.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5166856508772248001" "False" "High" "IsMasterProtein" "P01111" "GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1" "0.000" "False" "55.148" "37" "5" "9" "2" "189" "21.2" "5.17" "40.77" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00071" "4893" "ENSG00000213281" "NRAS" "hsa:4893; P01111; Q14971; Q15104; Q15282" "Neutrophil degranulation; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants" "Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "110" "3" "1.019" "1.010" "0.936" "0.978" "1.009" "0.919" "1.003" "1.038" "0.571" "827.1" "843.2" "835.7" "774.1" "808.7" "834.8" "760.2" "829.5" "858.2" "472.6" "" "" "" "" "" "" "" "" "" "" "733.5" "698.5" "729.2" "578.9" "674.4" "766.9" "642.5" "685.7" "787.0" "472.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "54.965" "12" "15" "17" "15" "1226" "136.0" "8.65" "59.16" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "PKR-mediated signaling; Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "Measles virus infection; Cytosolic DNA-sensing pathway" "6" "0" "1.068" "0.932" "1.173" "0.937" "0.912" "0.917" "0.583" "0.937" "6.057" "1174.5" "1254.9" "1094.5" "1377.5" "1100.3" "1071.5" "1077.2" "684.3" "1100.2" "7113.7" "" "" "" "" "" "" "" "" "" "" "1041.5" "1039.5" "955.0" "1030.2" "917.5" "984.3" "910.4" "565.6" "1009.0" "7113.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "54.898" "50" "8" "12" "8" "222" "23.8" "8.38" "52.77" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "Separation of Sister Chromatids; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "19" "0" "1.156" "1.123" "1.066" "1.165" "1.178" "1.031" "1.082" "1.047" "1.012" "700.5" "809.5" "787.0" "746.7" "815.8" "824.9" "722.5" "758.2" "733.6" "709.2" "" "" "" "" "" "" "" "" "" "" "621.2" "670.6" "686.7" "558.4" "680.3" "757.8" "610.6" "626.7" "672.8" "709.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6825792350743248999" "False" "High" "IsMasterProtein" "P07738" "Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2" "0.000" "False" "54.848" "40" "8" "9" "8" "259" "30.0" "6.54" "40.43" "8" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00300" "669" "ENSG00000172331" "BPGM" "A4D1N9; hsa:669; P07738" "Glycolysis" "IL-18 signaling pathway" "2" "0" "1.025" "0.986" "1.057" "1.056" "1.054" "1.151" "1.068" "1.046" "0.634" "1029.5" "1055.5" "1015.3" "1088.2" "1086.9" "1084.7" "1184.7" "1099.2" "1077.0" "652.2" "" "" "" "" "" "" "" "" "" "" "912.9" "874.3" "885.9" "813.8" "906.3" "996.4" "1001.2" "908.6" "987.8" "652.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.000" "False" "54.790" "22" "8" "11" "8" "445" "50.4" "8.27" "44.48" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Lipid metabolism pathway" "3" "0" "0.971" "1.004" "0.974" "1.008" "1.049" "1.010" "1.072" "1.043" "0.668" "1062.1" "1031.7" "1066.3" "1034.3" "1070.0" "1114.3" "1072.5" "1139.0" "1108.2" "709.9" "" "" "" "" "" "" "" "" "" "" "941.8" "854.6" "930.4" "773.5" "892.3" "1023.6" "906.5" "941.4" "1016.4" "709.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "54.774" "22" "7" "11" "7" "391" "44.1" "6.33" "46.72" "7" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "" "Tumor suppressor activity of SMARCB1" "1" "0" "1.008" "1.045" "1.062" "1.011" "0.989" "1.058" "0.939" "1.038" "2.219" "763.4" "769.9" "797.7" "811.0" "772.0" "754.7" "807.3" "716.5" "792.8" "1694.3" "" "" "" "" "" "" "" "" "" "" "677.0" "637.7" "696.0" "606.5" "643.7" "693.2" "682.3" "592.2" "727.1" "1694.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "54.753" "27" "10" "16" "10" "439" "50.4" "6.29" "57.93" "10" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle" "" "13" "0" "1.096" "1.062" "1.051" "0.989" "1.064" "1.164" "1.150" "1.053" "1.201" "1003.4" "1099.7" "1065.6" "1054.1" "992.3" "1067.5" "1168.2" "1153.5" "1056.7" "1205.1" "" "" "" "" "" "" "" "" "" "" "889.8" "910.9" "929.7" "788.3" "827.4" "980.6" "987.4" "953.4" "969.1" "1205.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2809797377402095157" "False" "High" "IsMasterProtein" "P42785" "Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1" "0.000" "False" "54.748" "21" "10" "16" "10" "496" "55.8" "7.21" "53.54" "10" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "5547" "ENSG00000137509" "PRCP" "A8MU24; B2R7B7; B3KRK5; B5BU34; hsa:5547; P42785" "Neutrophil degranulation; Intrinsic Pathway of Fibrin Clot Formation" "" "2" "0" "1.059" "1.057" "1.073" "1.111" "1.132" "1.024" "1.075" "0.978" "0.576" "1072.0" "1135.1" "1133.6" "1149.8" "1191.2" "1213.5" "1098.1" "1152.2" "1048.3" "617.3" "" "" "" "" "" "" "" "" "" "" "950.7" "940.2" "989.2" "859.9" "993.3" "1114.7" "928.1" "952.4" "961.5" "617.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.000" "False" "54.669" "20" "10" "15" "10" "515" "56.1" "6.32" "50.56" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.143" "1.032" "1.239" "1.179" "1.235" "1.135" "1.074" "1.054" "1.005" "494.2" "564.9" "510.1" "612.4" "582.5" "610.2" "561.1" "531.0" "520.7" "496.6" "" "" "" "" "" "" "" "" "" "" "438.2" "468.0" "445.1" "458.0" "485.8" "560.6" "474.2" "438.9" "477.6" "496.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "54.636" "45" "8" "15" "8" "190" "21.5" "4.94" "58.42" "8" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "0.932" "0.989" "0.915" "0.992" "1.020" "0.941" "0.977" "0.999" "0.437" "1711.7" "1595.5" "1692.8" "1566.2" "1698.0" "1745.5" "1610.3" "1672.2" "1710.4" "747.7" "" "" "" "" "" "" "" "" "" "" "1517.9" "1321.6" "1477.1" "1171.3" "1415.9" "1603.4" "1361.0" "1382.2" "1568.6" "747.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2769790673461720299" "False" "High" "IsMasterProtein" "Q96DF8" "Splicing factor ESS-2 homolog OS=Homo sapiens OX=9606 GN=ESS2 PE=1 SV=1" "0.000" "False" "54.635" "19" "7" "10" "7" "476" "52.5" "7.56" "45.04" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "" "Pf09751" "8220" "ENSG00000100056" "ESS2" "hsa:8220; Q49AH7; Q96DF8; Q9BTZ4" "" "22q11.2 copy number variation syndrome" "1" "0" "0.974" "0.972" "1.001" "0.910" "0.976" "0.949" "0.881" "1.029" "1.306" "871.9" "849.3" "847.1" "872.5" "793.3" "851.0" "827.4" "768.4" "897.5" "1138.7" "" "" "" "" "" "" "" "" "" "" "773.1" "703.5" "739.1" "652.5" "661.5" "781.7" "699.3" "635.1" "823.2" "1138.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "High" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.000" "False" "54.609" "35" "10" "12" "10" "325" "37.2" "8.05" "42.98" "10" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Primary focal segmental glomerulosclerosis (FSGS)" "3" "0" "1.039" "1.008" "1.027" "0.995" "1.040" "0.925" "0.964" "1.003" "0.597" "1053.0" "1094.3" "1061.8" "1081.2" "1047.7" "1095.2" "973.5" "1015.5" "1055.9" "629.1" "" "" "" "" "" "" "" "" "" "" "933.8" "906.4" "926.4" "808.6" "873.6" "1006.1" "822.8" "839.4" "968.4" "629.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "947873724462567429" "False" "High" "IsMasterProtein" "Q9UNQ2" "Dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "0.000" "False" "54.604" "31" "9" "13" "9" "313" "35.2" "9.99" "49.80" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "O76025; Q9BU77; Q9UES1; Q9UNQ2" "rRNA modification in the nucleus and cytosol" "" "1" "0" "0.972" "0.879" "1.017" "0.994" "0.959" "0.858" "0.812" "0.760" "0.789" "959.0" "932.1" "843.2" "975.0" "953.3" "919.3" "823.2" "778.5" "728.5" "756.2" "" "" "" "" "" "" "" "" "" "" "850.4" "772.1" "735.7" "729.1" "794.9" "844.5" "695.7" "643.5" "668.2" "756.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853605967738796226" "False" "High" "IsMasterProtein" "Q13137" "Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1" "0.000" "False" "54.551" "26" "11" "19" "11" "446" "52.2" "5.02" "61.50" "11" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17751" "10241" "ENSG00000136436" "CALCOCO2" "B2RBT0; B4DDC4; B4DDT4; B4DP36; B4E0C0; E7ENK0; E7ETP5; E9PBE5; hsa:10241; Q13137; Q53FQ5; Q53HB5; Q6IBN9; Q9BTF7" "" "" "0" "0" "0.960" "0.901" "1.051" "0.895" "0.905" "1.061" "0.900" "0.899" "1.315" "1593.1" "1529.4" "1435.5" "1673.7" "1426.5" "1442.1" "1689.8" "1434.5" "1432.1" "2094.3" "" "" "" "" "" "" "" "" "" "" "1412.7" "1266.9" "1252.6" "1251.7" "1189.5" "1324.7" "1428.1" "1185.7" "1313.4" "2094.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "54.540" "48" "4" "19" "4" "83" "9.1" "8.50" "69.12" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.012" "1.024" "1.035" "1.044" "1.094" "0.965" "1.016" "1.016" "0.568" "2213.6" "2239.6" "2266.5" "2290.7" "2310.4" "2422.4" "2135.1" "2248.9" "2249.4" "1256.8" "" "" "" "" "" "" "" "" "" "" "1963.0" "1855.2" "1977.7" "1713.2" "1926.5" "2225.3" "1804.5" "1858.8" "2063.0" "1256.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "54.504" "50" "8" "15" "8" "184" "21.4" "10.17" "58.48" "8" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.932" "0.994" "0.997" "0.953" "0.986" "0.981" "1.002" "0.998" "0.822" "3100.6" "2891.3" "3081.0" "3090.9" "2954.6" "3058.2" "3043.0" "3106.5" "3095.5" "2548.9" "" "" "" "" "" "" "" "" "" "" "2749.6" "2395.0" "2688.3" "2311.6" "2463.7" "2809.3" "2571.8" "2567.8" "2839.0" "2548.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1860975273197737865" "False" "High" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "0.000" "False" "54.425" "29" "9" "11" "8" "350" "41.2" "8.56" "42.89" "9" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "21" "0" "1.004" "0.930" "1.060" "0.964" "0.991" "1.034" "0.953" "0.918" "1.304" "459.1" "461.0" "426.9" "486.8" "442.6" "455.0" "474.6" "437.5" "421.6" "598.8" "" "" "" "" "" "" "" "" "" "" "407.2" "381.9" "372.5" "364.1" "369.1" "417.9" "401.1" "361.6" "386.7" "598.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "54.351" "34" "13" "16" "12" "370" "40.7" "7.21" "55.13" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "ESR-mediated signaling" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "4" "0" "1.001" "0.954" "1.080" "0.951" "0.905" "0.935" "0.450" "0.938" "8.275" "1177.3" "1178.3" "1123.3" "1271.2" "1119.3" "1065.4" "1101.3" "529.7" "1104.6" "9741.8" "" "" "" "" "" "" "" "" "" "" "1044.0" "976.0" "980.1" "950.7" "933.3" "978.7" "930.8" "437.8" "1013.1" "9741.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302134313779443403" "False" "High" "IsMasterProtein" "Q96ER3" "Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2" "0.000" "False" "54.335" "22" "9" "14" "9" "474" "53.5" "4.50" "59.18" "9" "other biological processes" "nucleus" "" "" "113174" "ENSG00000166788" "SAAL1" "A6NH05; hsa:113174; Q96ER3" "" "" "0" "0" "0.990" "0.983" "0.976" "0.962" "0.986" "1.067" "1.038" "1.114" "1.167" "1067.6" "1056.7" "1049.7" "1042.4" "1027.5" "1053.1" "1138.7" "1108.4" "1188.8" "1245.4" "" "" "" "" "" "" "" "" "" "" "946.7" "875.3" "915.9" "779.6" "856.8" "967.4" "962.4" "916.1" "1090.3" "1245.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "54.311" "36" "8" "14" "8" "300" "33.2" "4.98" "59.31" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "HATs acetylate histones" "" "1" "0" "1.059" "1.054" "1.101" "1.085" "1.034" "1.010" "1.012" "1.023" "0.701" "802.0" "849.6" "845.6" "883.1" "870.1" "829.2" "810.4" "811.6" "820.7" "562.0" "" "" "" "" "" "" "" "" "" "" "711.2" "703.8" "737.8" "660.5" "725.6" "761.7" "684.9" "670.8" "752.7" "562.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "High" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.000" "False" "54.241" "20" "7" "12" "7" "430" "47.1" "4.49" "46.72" "7" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "0.997" "0.966" "1.001" "0.985" "1.015" "0.967" "0.919" "0.959" "0.970" "1745.7" "1741.2" "1686.8" "1746.8" "1720.2" "1771.5" "1688.5" "1605.0" "1673.2" "1693.8" "" "" "" "" "" "" "" "" "" "" "1548.0" "1442.3" "1471.8" "1306.4" "1434.4" "1627.3" "1427.0" "1326.6" "1534.6" "1693.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "54.218" "30" "11" "17" "11" "377" "42.3" "6.83" "56.59" "11" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "1.028" "1.065" "1.071" "1.125" "1.160" "1.132" "1.196" "1.073" "0.572" "1311.3" "1347.7" "1396.0" "1404.1" "1475.5" "1521.3" "1484.5" "1568.9" "1406.8" "750.1" "" "" "" "" "" "" "" "" "" "" "1162.8" "1116.3" "1218.1" "1050.1" "1230.3" "1397.5" "1254.6" "1296.8" "1290.2" "750.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "54.097" "31" "5" "12" "5" "219" "24.6" "4.83" "52.89" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "Ferroptosis" "3" "0" "1.020" "1.061" "0.961" "0.990" "1.125" "0.992" "1.016" "1.053" "0.562" "857.9" "875.0" "910.0" "824.3" "849.3" "965.1" "851.4" "872.1" "903.3" "482.2" "" "" "" "" "" "" "" "" "" "" "760.8" "724.8" "794.0" "616.5" "708.2" "886.5" "719.6" "720.8" "828.5" "482.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "High" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.000" "False" "54.094" "68" "4" "15" "4" "85" "9.1" "9.31" "72.67" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "1.014" "1.037" "1.038" "0.980" "0.974" "1.025" "1.010" "0.960" "0.780" "1992.4" "2019.9" "2066.8" "2068.3" "1953.1" "1941.3" "2042.2" "2012.4" "1912.6" "1553.8" "" "" "" "" "" "" "" "" "" "" "1766.8" "1673.1" "1803.4" "1546.8" "1628.6" "1783.3" "1726.0" "1663.4" "1754.1" "1553.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "54.093" "44" "6" "22" "5" "154" "17.9" "8.51" "75.30" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "7" "0" "0.955" "0.997" "0.916" "0.979" "0.991" "0.967" "0.976" "0.940" "0.473" "2832.9" "2705.5" "2825.0" "2594.2" "2772.4" "2808.7" "2739.3" "2765.6" "2663.7" "1338.9" "" "" "" "" "" "" "" "" "" "" "2512.1" "2241.1" "2465.0" "1940.2" "2311.8" "2580.1" "2315.2" "2286.0" "2443.0" "1338.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4323681854308555372" "False" "High" "IsMasterProtein" "Q12830" "Nucleosome-remodeling factor subunit BPTF OS=Homo sapiens OX=9606 GN=BPTF PE=1 SV=3" "0.000" "False" "53.916" "4" "14" "17" "14" "3046" "338.1" "6.54" "49.22" "14" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf15613" "2186" "ENSG00000171634" "BPTF" "hsa:2186; Q12830; Q6NX67; Q7Z7D6; Q9UIG2" "" "Endoderm differentiation; 16p11.2 proximal deletion syndrome" "2" "0" "1.034" "0.988" "1.003" "0.937" "0.979" "0.967" "0.678" "0.943" "5.139" "494.6" "511.3" "488.8" "496.2" "463.6" "484.1" "478.3" "335.3" "466.6" "2542.1" "" "" "" "" "" "" "" "" "" "" "438.6" "423.5" "426.5" "371.1" "386.6" "444.7" "404.3" "277.2" "428.0" "2542.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "53.909" "69" "5" "28" "5" "96" "10.4" "4.48" "142.24" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "mRNA Splicing - Major Pathway" "" "1" "0" "1.104" "0.990" "1.178" "1.063" "1.043" "1.106" "0.985" "0.954" "0.550" "1587.4" "1751.8" "1571.6" "1869.4" "1686.8" "1655.2" "1755.4" "1563.2" "1513.9" "872.4" "" "" "" "" "" "" "" "" "" "" "1407.6" "1451.1" "1371.3" "1398.1" "1406.6" "1520.5" "1483.6" "1292.1" "1388.4" "872.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256219212228257535" "False" "High" "IsMasterProtein" "P15104" "Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4" "0.000" "False" "53.908" "27" "8" "11" "8" "373" "42.0" "6.89" "46.18" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00120, Pf03951" "2752" "ENSG00000135821" "GLUL" "hsa:2752; P15104; Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17" "Glutamate and glutamine metabolism; Astrocytic Glutamate-Glutamine Uptake And Metabolism" "TNF-alpha signaling pathway; Amino acid metabolism; Cell lineage map for neuronal differentiation" "5" "0" "0.996" "1.005" "0.956" "1.003" "1.019" "0.734" "0.764" "0.736" "0.523" "1861.0" "1853.9" "1870.9" "1778.9" "1866.9" "1895.7" "1365.8" "1422.5" "1368.9" "972.5" "" "" "" "" "" "" "" "" "" "" "1650.3" "1535.7" "1632.4" "1330.4" "1556.8" "1741.4" "1154.4" "1175.8" "1255.5" "972.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.000" "False" "53.809" "34" "6" "16" "6" "209" "23.6" "4.96" "57.99" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "5" "0" "1.061" "1.052" "0.991" "1.019" "1.024" "1.444" "1.576" "1.507" "0.729" "1359.7" "1443.0" "1430.1" "1347.0" "1385.2" "1392.0" "1963.9" "2143.1" "2049.1" "990.9" "" "" "" "" "" "" "" "" "" "" "1205.7" "1195.3" "1247.8" "1007.4" "1155.1" "1278.7" "1659.8" "1771.4" "1879.3" "990.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "53.807" "25" "4" "19" "4" "177" "20.2" "4.81" "78.73" "4" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.002" "1.003" "1.024" "1.019" "1.017" "0.953" "0.991" "0.866" "0.924" "2268.4" "2273.1" "2275.3" "2323.6" "2312.3" "2307.0" "2161.8" "2247.7" "1963.7" "2095.8" "" "" "" "" "" "" "" "" "" "" "2011.6" "1882.9" "1985.3" "1737.8" "1928.1" "2119.2" "1827.0" "1857.9" "1801.0" "2095.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "53.788" "18" "12" "13" "12" "751" "83.4" "7.01" "52.95" "12" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "Mitochondrial translation elongation" "" "1" "0" "0.895" "0.901" "0.914" "0.882" "0.974" "0.960" "0.796" "0.948" "4.399" "1394.6" "1248.4" "1257.0" "1274.5" "1229.4" "1357.9" "1338.4" "1110.6" "1322.7" "6134.4" "" "" "" "" "" "" "" "" "" "" "1236.7" "1034.1" "1096.8" "953.2" "1025.2" "1247.4" "1131.2" "918.0" "1213.1" "6134.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "53.776" "14" "10" "11" "10" "741" "82.5" "5.06" "41.08" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "Condensation of Prometaphase Chromosomes" "2q11.2 copy number variation syndrome" "2" "0" "1.067" "0.941" "1.077" "0.888" "0.857" "1.075" "0.461" "0.972" "11.293" "537.0" "573.0" "505.1" "578.2" "477.0" "460.0" "577.2" "247.8" "521.9" "6064.6" "" "" "" "" "" "" "" "" "" "" "476.2" "474.6" "440.7" "432.4" "397.8" "422.6" "487.8" "204.8" "478.6" "6064.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575582902092764945" "False" "High" "IsMasterProtein" "Q9NQA3" "WAS protein family homolog 6 OS=Homo sapiens OX=9606 GN=WASH6P PE=1 SV=3" "0.000" "False" "53.738" "16" "6" "10" "1" "447" "48.0" "5.67" "47.66" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH6P" "A6NGF1; Q8N305; Q9NQA3" "" "" "0" "0" "0.948" "0.942" "0.991" "1.032" "0.928" "1.051" "0.939" "1.025" "1.042" "259.2" "245.7" "244.3" "256.8" "267.6" "240.4" "272.5" "243.4" "265.8" "270.2" "" "" "" "" "" "" "" "" "" "" "229.9" "203.5" "213.2" "192.1" "223.1" "220.9" "230.3" "201.2" "243.8" "270.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "53.694" "28" "5" "10" "5" "238" "26.7" "7.24" "44.35" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "mRNA Splicing - Major Pathway" "" "1" "0" "0.899" "1.003" "0.951" "1.001" "1.032" "0.959" "1.021" "0.977" "0.483" "710.3" "638.9" "712.6" "675.5" "710.7" "732.9" "681.0" "725.4" "694.2" "343.1" "" "" "" "" "" "" "" "" "" "" "629.9" "529.2" "621.8" "505.2" "592.7" "673.3" "575.5" "599.6" "636.7" "343.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "53.682" "5" "10" "12" "10" "2146" "241.5" "6.55" "48.18" "10" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "0" "0.953" "0.958" "0.910" "0.936" "0.958" "0.920" "0.909" "0.932" "0.835" "1804.0" "1718.7" "1727.4" "1642.2" "1688.7" "1728.3" "1659.6" "1640.0" "1681.6" "1507.1" "" "" "" "" "" "" "" "" "" "" "1599.8" "1423.7" "1507.2" "1228.2" "1408.2" "1587.6" "1402.7" "1355.5" "1542.3" "1507.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.000" "False" "53.662" "32" "6" "12" "6" "221" "24.5" "7.39" "50.92" "6" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.957" "0.983" "0.921" "0.902" "0.948" "0.928" "0.931" "0.989" "0.393" "3044.9" "2912.8" "2993.0" "2803.0" "2747.0" "2886.1" "2825.4" "2834.6" "3010.7" "1197.6" "" "" "" "" "" "" "" "" "" "" "2700.2" "2412.8" "2611.5" "2096.2" "2290.6" "2651.2" "2387.9" "2343.0" "2761.2" "1197.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.000" "False" "53.661" "57" "4" "11" "2" "89" "10.3" "7.37" "54.14" "4" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "Separation of Sister Chromatids; MHC class II antigen presentation; Aggrephagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HCMV Early Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Intraflagellar transport; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Macroautophagy; Activation of BMF and translocation to mitochondria" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "19" "0" "0.928" "0.916" "0.986" "0.983" "1.123" "1.163" "1.101" "1.045" "1.045" "500.4" "464.3" "458.3" "493.6" "491.9" "561.9" "581.9" "550.9" "523.0" "522.9" "" "" "" "" "" "" "" "" "" "" "443.8" "384.6" "399.9" "369.1" "410.1" "516.2" "491.8" "455.4" "479.7" "522.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "53.644" "40" "6" "18" "6" "166" "18.2" "7.99" "63.86" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "mRNA Splicing - Major Pathway" "" "1" "0" "1.003" "1.018" "0.988" "1.025" "1.017" "1.001" "0.967" "0.978" "1.039" "1457.3" "1462.2" "1482.9" "1439.4" "1493.1" "1482.7" "1458.2" "1409.1" "1424.9" "1514.8" "" "" "" "" "" "" "" "" "" "" "1292.3" "1211.2" "1293.9" "1076.5" "1245.0" "1362.0" "1232.4" "1164.7" "1306.8" "1514.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370453687865171634" "False" "High" "IsMasterProtein" "P39880" "Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3" "0.000" "False" "53.503" "10" "13" "13" "13" "1505" "164.1" "5.90" "39.41" "13" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376" "1523" "ENSG00000257923" "CUX1" "B3KV79; J3KQV9; P39880; Q6NYH4; Q75LE5; Q75MT2; Q75MT3; Q86UJ7; Q9UEV5" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "0.931" "0.882" "0.874" "0.802" "0.886" "0.729" "0.709" "0.835" "2.278" "1840.3" "1713.8" "1623.2" "1608.8" "1475.1" "1631.3" "1342.1" "1305.2" "1537.2" "4191.7" "" "" "" "" "" "" "" "" "" "" "1632.0" "1419.6" "1416.3" "1203.1" "1230.0" "1498.6" "1134.3" "1078.9" "1409.8" "4191.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "53.490" "12" "15" "19" "15" "1268" "141.4" "6.87" "59.29" "15" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "HDL clearance" "2q37 copy number variation syndrome" "2" "0" "1.064" "0.982" "1.058" "0.987" "0.972" "1.043" "0.619" "1.058" "9.904" "721.2" "767.4" "708.2" "763.0" "712.1" "700.9" "752.3" "446.5" "762.9" "7142.2" "" "" "" "" "" "" "" "" "" "" "639.5" "635.6" "618.0" "570.6" "593.8" "643.9" "635.9" "369.0" "699.6" "7142.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079074271338885879" "False" "High" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "0.000" "False" "53.440" "38" "9" "20" "2" "213" "21.4" "10.93" "65.77" "9" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "0.818" "0.560" "0.599" "0.453" "0.318" "0.238" "0.447" "0.495" "0.238" "198.0" "162.0" "111.0" "118.7" "89.7" "63.0" "47.2" "88.5" "98.1" "47.1" "" "" "" "" "" "" "" "" "" "" "175.6" "134.2" "96.8" "88.7" "74.8" "57.9" "39.9" "73.1" "89.9" "47.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.000" "False" "53.427" "32" "9" "38" "9" "271" "29.8" "5.74" "80.39" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "" "59" "0" "1.021" "1.011" "1.061" "1.014" "0.962" "1.006" "1.025" "1.019" "0.873" "1198.9" "1223.8" "1211.5" "1271.8" "1215.4" "1153.5" "1205.8" "1228.8" "1221.7" "1047.2" "" "" "" "" "" "" "" "" "" "" "1063.2" "1013.8" "1057.1" "951.2" "1013.5" "1059.6" "1019.1" "1015.7" "1120.4" "1047.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "53.407" "21" "14" "14" "14" "683" "78.5" "6.87" "48.20" "14" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "Signaling by CSF1 (M-CSF) in myeloid cells; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "4" "0" "0.914" "0.903" "0.891" "0.817" "0.771" "0.789" "0.838" "0.918" "0.930" "1566.7" "1431.8" "1414.2" "1396.7" "1280.4" "1208.5" "1236.1" "1312.9" "1437.8" "1457.0" "" "" "" "" "" "" "" "" "" "" "1389.3" "1186.0" "1234.0" "1044.6" "1067.7" "1110.1" "1044.7" "1085.2" "1318.6" "1457.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "53.361" "25" "8" "21" "6" "286" "33.7" "9.36" "81.49" "8" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "RHOJ GTPase cycle; RHOH GTPase cycle" "" "2" "0" "1.023" "1.075" "1.029" "1.066" "1.087" "1.044" "1.092" "1.013" "0.465" "2067.3" "2115.0" "2223.2" "2126.3" "2204.0" "2246.3" "2157.4" "2257.2" "2093.4" "961.2" "" "" "" "" "" "" "" "" "" "" "1833.2" "1752.0" "1939.8" "1590.2" "1837.8" "2063.4" "1823.4" "1865.7" "1919.9" "961.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.000" "False" "53.342" "34" "13" "18" "13" "386" "43.5" "8.19" "61.12" "13" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "0.942" "0.948" "1.020" "0.933" "0.932" "1.141" "1.012" "0.961" "1.298" "1975.6" "1860.4" "1873.2" "2014.5" "1842.4" "1841.7" "2254.8" "1999.0" "1897.6" "2563.4" "" "" "" "" "" "" "" "" "" "" "1751.9" "1541.0" "1634.5" "1506.6" "1536.3" "1691.8" "1905.7" "1652.3" "1740.3" "2563.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8502957251701712576" "False" "High" "IsMasterProtein" "Q9UHW5" "GPN-loop GTPase 3 OS=Homo sapiens OX=9606 GN=GPN3 PE=1 SV=2" "0.000" "False" "53.275" "39" "7" "11" "7" "284" "32.7" "4.50" "41.56" "7" "" "other cell component" "other molecular function" "Pf03029" "51184" "ENSG00000111231" "GPN3" "B2RC54; D4YWV1; F5H759; hsa:51184; Q53FS3; Q6UVZ6; Q7Z3D3; Q8NEI2; Q96HK9; Q9UHW5" "" "" "0" "0" "1.067" "0.944" "1.112" "1.086" "1.032" "1.084" "1.024" "0.871" "0.641" "576.7" "615.1" "544.5" "641.3" "626.3" "595.4" "625.3" "590.5" "502.5" "369.4" "" "" "" "" "" "" "" "" "" "" "511.4" "509.5" "475.1" "479.6" "522.2" "546.9" "528.5" "488.1" "460.9" "369.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2602489287625283403" "False" "High" "IsMasterProtein" "P62330" "ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2" "0.000" "False" "53.251" "39" "6" "12" "5" "175" "20.1" "8.95" "49.49" "6" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00025" "382" "ENSG00000165527" "ARF6" "hsa:382; P26438; P62330; Q6FGZ2" "Clathrin-mediated endocytosis; TBC/RABGAPs; MET receptor recycling" "VEGFA-VEGFR2 signaling; Ras signaling; EGF/EGFR signaling pathway; IL-18 signaling pathway; Insulin signaling; CCL18 signaling pathway; 2q13 copy number variation syndrome" "10" "0" "0.991" "1.039" "1.063" "1.039" "1.042" "1.072" "1.097" "0.949" "0.567" "1506.4" "1493.0" "1565.8" "1601.0" "1565.3" "1569.5" "1614.2" "1652.3" "1429.1" "853.8" "" "" "" "" "" "" "" "" "" "" "1335.9" "1236.8" "1366.3" "1197.3" "1305.3" "1441.7" "1364.2" "1365.8" "1310.6" "853.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "High" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.000" "False" "53.250" "49" "3" "8" "3" "76" "8.5" "4.36" "37.56" "3" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "HSF1 activation; Attenuation phase" "" "3" "0" "1.051" "1.018" "1.054" "1.041" "0.929" "0.997" "0.999" "1.059" "0.554" "1082.3" "1137.0" "1101.3" "1140.9" "1126.4" "1005.0" "1079.3" "1081.2" "1146.1" "599.1" "" "" "" "" "" "" "" "" "" "" "959.8" "941.8" "960.9" "853.2" "939.3" "923.2" "912.2" "893.7" "1051.1" "599.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "53.214" "25" "5" "16" "5" "216" "25.1" "6.73" "61.54" "5" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Signaling by Hippo" "Pleural mesothelioma" "2" "0" "1.017" "1.075" "1.061" "1.041" "1.003" "0.993" "1.036" "0.937" "0.626" "1920.6" "1953.1" "2065.3" "2036.9" "2000.0" "1926.9" "1907.9" "1990.3" "1798.9" "1202.5" "" "" "" "" "" "" "" "" "" "" "1703.1" "1617.9" "1802.1" "1523.3" "1667.7" "1770.1" "1612.5" "1645.1" "1649.8" "1202.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "53.207" "13" "8" "10" "8" "669" "72.4" "8.34" "42.03" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "1.023" "1.029" "1.112" "1.104" "1.060" "1.160" "1.087" "1.005" "1.249" "1201.1" "1228.4" "1236.0" "1335.1" "1326.3" "1273.4" "1393.5" "1306.2" "1207.5" "1500.4" "" "" "" "" "" "" "" "" "" "" "1065.1" "1017.6" "1078.5" "998.5" "1105.9" "1169.7" "1177.7" "1079.7" "1107.4" "1500.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097658218394758056" "False" "High" "IsMasterProtein" "P54259" "Atrophin-1 OS=Homo sapiens OX=9606 GN=ATN1 PE=1 SV=3" "0.000" "False" "53.173" "8" "8" "12" "7" "1190" "125.3" "8.98" "45.97" "8" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03154" "1822" "ENSG00000111676" "ATN1" "hsa:1822; P54259; Q99495; Q99621; Q9UEK7" "Regulation of PTEN gene transcription" "" "1" "0" "0.968" "0.922" "0.961" "0.923" "0.943" "0.857" "0.885" "0.932" "0.501" "1214.7" "1176.1" "1120.0" "1167.4" "1121.6" "1146.0" "1040.4" "1075.2" "1132.3" "608.7" "" "" "" "" "" "" "" "" "" "" "1077.2" "974.2" "977.3" "873.0" "935.3" "1052.7" "879.3" "888.7" "1038.5" "608.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "53.095" "21" "10" "15" "10" "580" "64.2" "8.41" "55.51" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "Male infertility" "10" "0" "1.023" "0.983" "1.152" "1.051" "0.998" "1.056" "1.034" "0.948" "0.645" "1599.1" "1636.3" "1571.4" "1842.6" "1681.4" "1596.4" "1687.9" "1654.2" "1516.7" "1031.3" "" "" "" "" "" "" "" "" "" "" "1418.0" "1355.4" "1371.1" "1378.0" "1402.0" "1466.4" "1426.6" "1367.3" "1391.0" "1031.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7530688595643988973" "False" "High" "IsMasterProtein" "Q13510" "Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5" "0.000" "False" "53.086" "24" "10" "18" "10" "395" "44.6" "7.62" "56.87" "10" "other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "427" "ENSG00000104763" "ASAH1" "E9PDS0; hsa:427; Q13510; Q6W898; Q96AS2" "Neutrophil degranulation; Glycosphingolipid catabolism" "Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Synthesis of ceramides and 1-deoxyceramides" "8" "0" "1.031" "1.052" "0.941" "1.000" "1.093" "0.980" "0.976" "1.006" "0.602" "2320.3" "2392.3" "2441.6" "2182.5" "2320.1" "2535.1" "2274.6" "2264.6" "2334.4" "1397.3" "" "" "" "" "" "" "" "" "" "" "2057.6" "1981.7" "2130.4" "1632.2" "1934.6" "2328.8" "1922.4" "1871.8" "2140.9" "1397.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "53.064" "26" "10" "13" "10" "392" "42.2" "6.32" "49.35" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "1.062" "1.060" "1.067" "1.080" "0.986" "1.113" "1.075" "1.124" "0.745" "1332.6" "1415.0" "1412.2" "1422.3" "1439.1" "1313.8" "1483.6" "1432.9" "1498.2" "992.4" "" "" "" "" "" "" "" "" "" "" "1181.7" "1172.1" "1232.2" "1063.7" "1200.0" "1206.9" "1253.8" "1184.4" "1374.0" "992.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5875198809388005970" "False" "High" "IsMasterProtein" "Q9H3H3" "UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3" "0.000" "False" "53.042" "27" "8" "11" "8" "292" "31.4" "6.32" "44.82" "8" "" "" "" "Pf08939" "83638" "ENSG00000175573" "C11orf68" "hsa:83638; J3KQG9; Q9BT13; Q9H3H3" "" "" "0" "0" "1.018" "0.996" "1.047" "1.003" "0.988" "1.189" "1.166" "1.083" "0.974" "906.7" "923.0" "903.3" "949.2" "909.0" "895.8" "1077.7" "1057.2" "982.3" "883.6" "" "" "" "" "" "" "" "" "" "" "804.1" "764.6" "788.1" "709.8" "758.0" "822.9" "910.8" "873.8" "900.9" "883.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6221912277285666984" "False" "High" "IsMasterProtein" "Q5TC12" "ATP synthase mitochondrial F1 complex assembly factor 1 OS=Homo sapiens OX=9606 GN=ATPAF1 PE=1 SV=1" "0.000" "False" "53.037" "29" "8" "10" "8" "328" "36.4" "7.96" "39.87" "8" "cell organization and biogenesis" "mitochondrion" "" "Pf06644" "64756" "ENSG00000123472" "ATPAF1" "B1AQW7; B7Z7D6; B7Z7I6; hsa:64756; Q5TC12; Q9H6E3" "" "7q11.23 copy number variation syndrome" "1" "0" "1.150" "1.057" "1.149" "1.110" "1.066" "1.202" "1.060" "1.058" "0.729" "1185.0" "1362.5" "1252.2" "1361.9" "1315.5" "1263.3" "1424.5" "1256.1" "1253.1" "864.3" "" "" "" "" "" "" "" "" "" "" "1050.8" "1128.6" "1092.6" "1018.5" "1096.9" "1160.5" "1203.9" "1038.3" "1149.3" "864.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5434950316255047491" "False" "High" "IsMasterProtein" "P42224" "Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2" "0.000" "False" "53.031" "20" "12" "13" "12" "750" "87.3" "6.05" "51.79" "12" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12162, Pf21354" "6772" "ENSG00000115415" "STAT1" "A8K989; B2RCA0; D2KFR8; D3DPI7; hsa:6772; P42224; Q53S88; Q53XW4; Q68D00; Q9UDL5" "Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Regulation of RUNX2 expression and activity; PKR-mediated signaling; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Downstream signal transduction; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Growth hormone receptor signaling; Interleukin-6 signaling; Interferon alpha/beta signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH3 Intracellular Domain Regulates Transcription; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-27 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Allograft rejection; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Kit receptor signaling pathway; IL6 signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Immune response to tuberculosis; Ebola virus infection in host; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Tryptophan metabolism; Hepatitis B infection; Endochondral ossification; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; CCL18 signaling pathway; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; 2q13 copy number variation syndrome; TROP2 regulatory signaling; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Type II interferon signaling; Toll-like receptor signaling pathway" "83" "0" "0.984" "0.834" "1.049" "1.030" "0.981" "1.099" "0.285" "0.823" "13.740" "91.7" "90.3" "76.4" "96.2" "94.4" "90.0" "100.7" "26.1" "75.4" "1259.8" "" "" "" "" "" "" "" "" "" "" "81.3" "74.8" "66.7" "71.9" "78.7" "82.6" "85.1" "21.6" "69.2" "1259.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2116736278876107348" "False" "High" "IsMasterProtein" "Q8IW45" "ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Homo sapiens OX=9606 GN=NAXD PE=1 SV=1" "0.000" "False" "53.022" "20" "6" "9" "6" "347" "36.6" "8.06" "36.86" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01256" "55739" "ENSG00000213995" "NAXD" "B4DXT4; hsa:55739; Q5T9X3; Q8IW45; Q9H7W1; Q9NVF5" "Nicotinamide salvaging" "" "1" "0" "1.016" "1.000" "1.086" "1.053" "1.038" "0.992" "1.029" "1.004" "0.550" "1017.2" "1033.4" "1017.2" "1104.3" "1071.1" "1055.6" "1008.7" "1046.2" "1021.2" "559.1" "" "" "" "" "" "" "" "" "" "" "902.0" "856.0" "887.5" "825.9" "893.1" "969.7" "852.5" "864.8" "936.6" "559.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "52.989" "24" "8" "13" "8" "439" "48.5" "7.03" "55.16" "8" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Glutamate and glutamine metabolism" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "4" "0" "1.039" "0.985" "1.094" "1.114" "1.208" "1.277" "1.192" "1.104" "0.843" "1265.4" "1314.5" "1246.6" "1384.0" "1409.8" "1528.6" "1615.9" "1509.0" "1396.9" "1066.6" "" "" "" "" "" "" "" "" "" "" "1122.2" "1088.9" "1087.8" "1035.1" "1175.5" "1404.2" "1365.7" "1247.3" "1281.2" "1066.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "High" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.000" "False" "52.945" "21" "9" "11" "9" "562" "63.6" "7.85" "40.38" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.050" "0.997" "1.120" "1.065" "0.992" "0.961" "0.911" "0.886" "1.283" "696.3" "731.1" "694.2" "779.6" "741.2" "690.5" "669.2" "634.6" "617.2" "893.3" "" "" "" "" "" "" "" "" "" "" "617.4" "605.6" "605.7" "583.0" "618.1" "634.3" "565.6" "524.6" "566.0" "893.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198738028437086806" "False" "High" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "0.000" "False" "52.891" "12" "10" "14" "10" "902" "101.4" "8.40" "48.42" "10" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "0.967" "0.962" "0.993" "0.921" "0.895" "1.081" "0.921" "1.055" "2.979" "678.9" "656.8" "653.2" "674.1" "625.0" "607.8" "733.9" "625.1" "716.1" "2022.3" "" "" "" "" "" "" "" "" "" "" "602.0" "544.1" "569.9" "504.1" "521.2" "558.3" "620.3" "516.7" "656.7" "2022.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "52.857" "26" "11" "16" "11" "350" "39.6" "9.70" "57.73" "11" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Regulation of PTEN stability and activity; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "64" "0" "1.011" "1.157" "1.059" "1.191" "1.132" "1.247" "1.263" "1.172" "0.801" "1285.1" "1298.9" "1487.0" "1361.3" "1530.2" "1455.2" "1602.5" "1622.9" "1505.6" "1029.0" "" "" "" "" "" "" "" "" "" "" "1139.6" "1076.0" "1297.5" "1018.0" "1276.0" "1336.7" "1354.4" "1341.4" "1380.9" "1029.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2458252490920426752" "False" "High" "IsMasterProtein" "P16402" "Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2" "0.000" "False" "52.844" "32" "8" "18" "2" "221" "22.3" "11.02" "63.66" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3007" "ENSG00000124575" "H1-3" "B2R751; hsa:3007; P16402; Q2M2I2" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "0.836" "0.739" "0.647" "0.672" "0.742" "0.663" "0.634" "0.652" "0.262" "226.9" "189.7" "167.8" "146.9" "152.5" "168.4" "150.4" "144.0" "147.9" "59.5" "" "" "" "" "" "" "" "" "" "" "201.2" "157.1" "146.4" "109.8" "127.2" "154.7" "127.2" "119.0" "135.7" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.000" "False" "52.811" "66" "7" "21" "7" "99" "11.3" "9.31" "76.75" "7" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "1.000" "0.972" "1.066" "0.972" "1.020" "1.067" "1.101" "1.052" "0.544" "2576.7" "2577.6" "2505.8" "2745.7" "2505.6" "2628.4" "2748.6" "2837.7" "2711.7" "1402.3" "" "" "" "" "" "" "" "" "" "" "2285.0" "2135.1" "2186.5" "2053.4" "2089.4" "2414.5" "2323.0" "2345.6" "2487.0" "1402.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611257715597886633" "False" "High" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.000" "False" "52.784" "28" "8" "15" "8" "327" "37.0" "5.57" "53.60" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "" "Ciliary landscape" "1" "0" "0.980" "0.968" "0.979" "0.854" "0.859" "0.853" "0.559" "0.951" "7.295" "407.1" "398.8" "394.0" "398.4" "347.5" "349.7" "347.4" "227.7" "387.1" "2969.7" "" "" "" "" "" "" "" "" "" "" "361.0" "330.3" "343.8" "297.9" "289.8" "321.2" "293.6" "188.2" "355.0" "2969.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "High" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.000" "False" "52.765" "19" "13" "14" "13" "718" "81.0" "7.30" "49.82" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.064" "0.971" "1.086" "1.030" "1.040" "0.949" "0.961" "0.901" "1.054" "1328.5" "1413.7" "1289.4" "1442.8" "1368.7" "1382.3" "1260.2" "1276.9" "1196.8" "1400.5" "" "" "" "" "" "" "" "" "" "" "1178.1" "1171.1" "1125.1" "1079.0" "1141.3" "1269.8" "1065.1" "1055.4" "1097.6" "1400.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "52.763" "48" "3" "21" "3" "113" "12.7" "7.44" "100.83" "3" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "2" "0" "0.952" "1.001" "0.953" "1.000" "1.040" "0.999" "1.081" "1.033" "0.436" "2381.8" "2268.3" "2383.1" "2271.0" "2380.8" "2476.2" "2378.9" "2573.8" "2459.8" "1039.6" "" "" "" "" "" "" "" "" "" "" "2112.1" "1879.0" "2079.4" "1698.4" "1985.3" "2274.6" "2010.5" "2127.4" "2256.0" "1039.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.000" "False" "52.753" "14" "7" "13" "7" "689" "74.3" "9.57" "65.01" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "2" "0" "0.951" "0.945" "1.048" "0.959" "0.931" "0.970" "0.903" "0.929" "0.768" "638.8" "607.5" "603.6" "669.3" "612.6" "594.7" "619.4" "577.1" "593.7" "490.8" "" "" "" "" "" "" "" "" "" "" "566.5" "503.2" "526.6" "500.5" "510.9" "546.3" "523.5" "477.0" "544.5" "490.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.000" "False" "52.694" "26" "11" "13" "11" "445" "52.2" "6.04" "47.95" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.943" "0.896" "0.962" "0.961" "0.937" "0.920" "0.565" "0.941" "8.523" "616.7" "581.3" "552.5" "593.2" "592.6" "578.0" "567.2" "348.4" "580.4" "5256.2" "" "" "" "" "" "" "" "" "" "" "546.9" "481.5" "482.0" "443.6" "494.2" "530.9" "479.4" "288.0" "532.3" "5256.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "52.688" "54" "12" "17" "12" "223" "25.8" "9.54" "56.00" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.973" "0.948" "0.941" "0.954" "1.091" "1.071" "0.969" "1.026" "0.421" "2268.9" "2207.3" "2150.6" "2135.9" "2163.5" "2474.5" "2430.6" "2198.9" "2328.9" "955.8" "" "" "" "" "" "" "" "" "" "" "2012.1" "1828.4" "1876.5" "1597.4" "1804.0" "2273.1" "2054.2" "1817.5" "2135.9" "955.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "52.656" "27" "4" "14" "4" "209" "23.2" "5.38" "62.52" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Neddylation; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "Ciliary landscape; 2q37 copy number variation syndrome" "6" "0" "1.069" "1.033" "1.227" "1.098" "1.012" "1.164" "1.026" "1.015" "0.663" "786.7" "840.7" "812.8" "965.1" "863.6" "796.5" "916.1" "806.9" "798.1" "521.2" "" "" "" "" "" "" "" "" "" "" "697.6" "696.4" "709.2" "721.8" "720.1" "731.7" "774.3" "667.0" "732.0" "521.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5315083588279200367" "False" "High" "IsMasterProtein" "Q96FZ2" "Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1" "0.000" "False" "52.654" "32" "11" "15" "11" "354" "40.5" "8.15" "56.82" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02586" "56941" "ENSG00000183624" "HMCES" "A6NJR9; hsa:56941; Q96FZ2; Q96G34; Q9NRP3" "" "" "0" "0" "1.054" "0.834" "1.019" "0.956" "0.950" "1.115" "0.530" "1.414" "11.249" "1122.2" "1183.2" "935.5" "1143.5" "1072.4" "1066.3" "1251.7" "595.0" "1586.5" "12622.9" "" "" "" "" "" "" "" "" "" "" "995.1" "980.1" "816.3" "855.2" "894.3" "979.5" "1057.9" "491.8" "1455.0" "12622.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "52.576" "37" "9" "20" "2" "219" "21.9" "11.03" "66.67" "9" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Pathways affected in adenoid cystic carcinoma" "3" "5" "0.881" "0.851" "0.813" "0.799" "0.845" "0.739" "0.753" "0.737" "0.301" "2747.1" "2420.2" "2336.8" "2233.7" "2194.8" "2322.6" "2030.1" "2068.7" "2024.2" "827.0" "" "" "" "" "" "" "" "" "" "" "2436.0" "2004.8" "2039.0" "1670.5" "1830.2" "2133.5" "1715.7" "1709.9" "1856.4" "827.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3957617844882623254" "False" "High" "IsMasterProtein" "Q7Z3B4" "Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2" "0.000" "False" "52.414" "21" "10" "11" "10" "507" "55.4" "7.02" "43.30" "10" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13874, Pf18437" "53371" "ENSG00000138750" "NUP54" "B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1" "Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.997" "0.880" "1.047" "0.915" "0.843" "1.077" "0.863" "0.966" "3.081" "832.3" "829.5" "732.4" "871.4" "761.5" "701.3" "896.2" "718.6" "803.8" "2564.4" "" "" "" "" "" "" "" "" "" "" "738.1" "687.1" "639.0" "651.7" "635.0" "644.2" "757.4" "593.9" "737.2" "2564.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158651141849584646" "False" "High" "IsMasterProtein" "Q9Y294" "Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1" "0.000" "False" "52.362" "29" "4" "15" "3" "204" "23.0" "4.41" "78.66" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04729" "25842" "ENSG00000111875" "ASF1A" "hsa:25842; Q6IA08; Q9P014; Q9Y294" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "22q11.2 copy number variation syndrome" "2" "1" "1.065" "1.058" "1.062" "1.108" "1.150" "0.912" "0.930" "0.922" "0.810" "1511.8" "1610.7" "1599.9" "1606.0" "1674.7" "1738.0" "1378.2" "1406.2" "1394.0" "1225.2" "" "" "" "" "" "" "" "" "" "" "1340.7" "1334.2" "1396.0" "1201.1" "1396.4" "1596.5" "1164.8" "1162.4" "1278.5" "1225.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6364343737777032179" "False" "High" "IsMasterProtein" "P08754" "Guanine nucleotide-binding protein G(i) subunit alpha-3 OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3" "0.000" "False" "52.281" "25" "8" "16" "4" "354" "40.5" "5.69" "58.57" "8" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2773" "ENSG00000065135" "GNAI3" "hsa:2773; P08754; P17539; Q5TZX1" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production" "Thyroid stimulating hormone (TSH) signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "18" "0" "1.196" "0.971" "0.935" "1.137" "1.199" "1.189" "1.151" "1.309" "0.942" "266.5" "318.8" "258.8" "249.2" "303.1" "319.6" "317.0" "306.8" "348.8" "251.2" "" "" "" "" "" "" "" "" "" "" "236.3" "264.0" "225.8" "186.4" "252.8" "293.5" "267.9" "253.6" "319.9" "251.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "High" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.000" "False" "52.281" "5" "17" "20" "15" "3114" "357.3" "5.10" "53.66" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Polo-like kinase mediated events" "Gastric cancer network 1; Ciliopathies" "9" "1" "1.026" "1.033" "1.060" "0.982" "0.994" "0.950" "0.936" "0.942" "1.031" "1076.1" "1103.8" "1111.8" "1140.3" "1056.6" "1070.0" "1022.2" "1007.7" "1013.7" "1109.9" "" "" "" "" "" "" "" "" "" "" "954.2" "914.3" "970.1" "852.8" "881.1" "982.9" "863.9" "832.9" "929.7" "1109.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8120903851432865653" "False" "High" "IsMasterProtein" "P01889" "HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3" "0.000" "False" "52.234" "25" "7" "9" "3" "362" "40.4" "5.85" "40.47" "7" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3106" "ENSG00000234745" "HLA-B" "A0A2I6Q7B5; B0V0B8; G3GN01; hsa:3106; O02862; O02956; O02957; O02960; O19555; O19556; O19595; O19615; O19624; O19625; O19627; O19641; O19651; O19675; O19692; O19758; O19779; O19783; O46702; O62897; O62901; O62915; O62917; O62919; O77933; O77959; O78053; O78138; O78160; O78163; O78172; O78173; O78180; O78217; O95730; O98140; P01889; P01890; P03989; P10317; P10318; P10319; P10320; P18463; P18464; P18465; P19373; P30460; P30461; P30462; P30463; P30464; P30465; P30466; P30467; P30468; P30469; P30470; P30471; P30472; P30473; P30474; P30475; P30476; P30477; P30478; P30479; P30480; P30481; P30482; P30483; P30484; P30485; P30486; P30487; P30488; P30489; P30490; P30491; P30492; P30493; P30494; P30495; P30496; P30497; P30498; P30513; P30685; P79489; P79490; P79496; P79504; P79523; P79524; P79542; P79555; Q04826; Q08136; Q29633; Q29636; Q29638; Q29661; Q29665; Q29678; Q29679; Q29681; Q29693; Q29695; Q29697; Q29718; Q29742; Q29749; Q29762; Q29764; Q29829; Q29836; Q29842; Q29845; Q29846; Q29847; Q29848; Q29850; Q29851; Q29852; Q29854; Q29855; Q29857; Q29858; Q29861; Q29924; Q29925; Q29933; Q29935; Q29936; Q29940; Q29953; Q29961; Q29982; Q30173; Q30198; Q31603; Q31610; Q31612; Q31613; Q546L8; Q546M4; Q5JP37; Q5QT24; Q5RIP1; Q5SRJ2; Q5TK76; Q5TK77; Q860I4; Q861B5; Q8HWF0; Q8MGQ3; Q8MHN4; Q8SNC5; Q95343; Q95344; Q95365; Q95369; Q95392; Q95HA3; Q95HA8; Q95HM9; Q95IA6; Q95IB8; Q95IH5; Q95J00; Q96IT9; Q9BCM6; Q9BCM7; Q9BCM8; Q9BD06; Q9BD38; Q9BD43; Q9GIL3; Q9GIM3; Q9GIX1; Q9GIY5; Q9GIZ0; Q9GIZ9; Q9GJ00; Q9GJ17; Q9GJ20; Q9GJ23; Q9GJ31; Q9GJF0; Q9GJM7; Q9MX21; Q9MY37; Q9MY42; Q9MY43; Q9MY61; Q9MY75; Q9MY78; Q9MY79; Q9MY84; Q9MY92; Q9MY93; Q9MY94; Q9MYB8; Q9MYC3; Q9MYC7; Q9MYF4; Q9MYG1; Q9TP35; Q9TP36; Q9TP37; Q9TP95; Q9TPQ7; Q9TPQ9; Q9TPR2; Q9TPR4; Q9TPS6; Q9TPT2; Q9TPT4; Q9TPT6; Q9TPV2; Q9TQG1; Q9TQH3; Q9TQH6; Q9TQH7; Q9TQH8; Q9TQH9; Q9TQM2; Q9TQN4; Q9TQN6; Q9UQS8; Q9UQT0" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 interactions; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome; Type II interferon signaling" "14" "4" "1.027" "0.976" "1.041" "0.979" "0.940" "1.022" "1.016" "1.077" "0.698" "1511.3" "1552.1" "1475.1" "1573.5" "1479.3" "1421.3" "1544.6" "1534.8" "1627.1" "1054.8" "" "" "" "" "" "" "" "" "" "" "1340.2" "1285.7" "1287.1" "1176.7" "1233.6" "1305.6" "1305.4" "1268.6" "1492.2" "1054.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1882529908578060163" "False" "High" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "0.000" "False" "52.221" "28" "11" "12" "11" "396" "44.6" "5.03" "45.43" "11" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "1.043" "0.945" "0.967" "0.985" "0.962" "1.015" "0.931" "0.922" "0.920" "1200.0" "1251.2" "1134.2" "1159.9" "1182.5" "1155.0" "1218.6" "1117.5" "1106.9" "1104.5" "" "" "" "" "" "" "" "" "" "" "1064.2" "1036.4" "989.7" "867.4" "986.1" "1061.0" "1029.9" "923.7" "1015.2" "1104.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "52.107" "27" "3" "8" "3" "195" "22.0" "5.44" "37.61" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "30" "0" "1.103" "1.058" "1.069" "1.085" "1.068" "1.166" "1.055" "0.998" "1.470" "516.7" "569.7" "546.6" "552.1" "560.3" "551.6" "602.6" "545.0" "515.6" "759.5" "" "" "" "" "" "" "" "" "" "" "458.2" "471.9" "477.0" "412.9" "467.2" "506.7" "509.3" "450.5" "472.8" "759.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "52.077" "28" "6" "8" "6" "258" "28.8" "6.65" "36.05" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "" "2" "0" "0.993" "1.023" "1.027" "1.038" "1.027" "1.023" "1.015" "1.018" "0.852" "1193.2" "1184.6" "1220.1" "1225.0" "1239.1" "1225.6" "1220.8" "1211.1" "1214.4" "1016.8" "" "" "" "" "" "" "" "" "" "" "1058.1" "981.3" "1064.6" "916.1" "1033.2" "1125.8" "1031.8" "1001.0" "1113.7" "1016.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "52.075" "24" "10" "12" "10" "509" "54.8" "5.59" "44.80" "10" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway" "2" "0" "1.023" "0.899" "1.028" "1.032" "0.938" "0.990" "0.737" "0.970" "6.169" "668.4" "683.6" "601.2" "686.8" "690.2" "627.1" "661.9" "492.4" "648.6" "4123.4" "" "" "" "" "" "" "" "" "" "" "592.8" "566.3" "524.6" "513.7" "575.5" "576.1" "559.4" "407.0" "594.9" "4123.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "499510966834701259" "False" "High" "IsMasterProtein" "Q96GS4" "BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2" "0.000" "False" "51.929" "21" "5" "8" "5" "357" "37.2" "5.76" "31.60" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10157" "54785" "ENSG00000196544" "BORCS6" "hsa:54785; Q53HS4; Q96GS4; Q9NXW8" "" "" "0" "0" "1.090" "1.035" "1.044" "0.990" "0.946" "0.983" "0.901" "1.002" "0.697" "568.1" "619.4" "588.0" "593.3" "562.7" "537.3" "558.3" "511.8" "569.4" "395.7" "" "" "" "" "" "" "" "" "" "" "503.8" "513.1" "513.0" "443.7" "469.2" "493.6" "471.8" "423.1" "522.2" "395.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "51.921" "32" "8" "11" "8" "264" "30.5" "9.80" "47.83" "8" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "mRNA Splicing - Major Pathway" "" "1" "0" "0.981" "0.944" "1.067" "1.030" "1.016" "0.964" "0.921" "0.938" "0.523" "1120.7" "1098.8" "1058.4" "1195.4" "1153.8" "1138.8" "1080.0" "1032.6" "1051.4" "586.6" "" "" "" "" "" "" "" "" "" "" "993.8" "910.2" "923.5" "894.0" "962.1" "1046.1" "912.8" "853.5" "964.3" "586.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "51.844" "20" "9" "12" "9" "492" "52.0" "6.48" "50.30" "9" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "tRNA modification in the mitochondrion" "" "1" "0" "1.031" "0.987" "1.084" "1.061" "0.980" "1.008" "1.014" "0.908" "0.553" "1183.7" "1220.3" "1168.9" "1282.6" "1256.4" "1160.0" "1193.1" "1200.5" "1075.4" "655.0" "" "" "" "" "" "" "" "" "" "" "1049.7" "1010.9" "1019.9" "959.2" "1047.6" "1065.6" "1008.3" "992.3" "986.3" "655.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "51.816" "34" "9" "12" "9" "298" "32.8" "9.57" "47.53" "9" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "Base excision repair; DNA repair pathways, full network" "5" "0" "1.029" "1.074" "1.036" "0.982" "1.055" "1.014" "0.977" "0.955" "0.893" "402.1" "414.0" "431.9" "416.4" "394.8" "424.2" "407.6" "392.9" "384.0" "359.1" "" "" "" "" "" "" "" "" "" "" "356.6" "342.9" "376.9" "311.4" "329.2" "389.6" "344.5" "324.7" "352.2" "359.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "51.807" "9" "9" "9" "9" "1219" "133.5" "5.20" "39.61" "9" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "" "TYROBP causal network in microglia" "1" "0" "1.091" "0.915" "1.073" "0.986" "0.894" "0.986" "0.911" "0.953" "2.143" "659.0" "719.0" "603.0" "707.4" "650.0" "589.2" "649.6" "600.2" "628.1" "1412.4" "" "" "" "" "" "" "" "" "" "" "584.4" "595.6" "526.2" "529.0" "542.0" "541.2" "549.0" "496.1" "576.1" "1412.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871299150167349072" "False" "High" "IsMasterProtein" "Q8TF68" "Zinc finger protein 384 OS=Homo sapiens OX=9606 GN=ZNF384 PE=1 SV=2" "0.000" "False" "51.738" "15" "7" "13" "7" "577" "63.2" "8.95" "63.48" "7" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "171017" "ENSG00000126746" "ZNF384" "hsa:171017; O15407; Q7Z722; Q8N938; Q8TF68" "" "" "0" "0" "1.013" "1.126" "0.973" "1.038" "1.059" "1.038" "0.991" "1.072" "1.212" "654.5" "662.7" "736.8" "636.8" "679.1" "693.1" "679.4" "648.9" "701.4" "793.1" "" "" "" "" "" "" "" "" "" "" "580.4" "548.9" "642.9" "476.2" "566.3" "636.7" "574.2" "536.4" "643.3" "793.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6046703873344704710" "False" "High" "IsMasterProtein" "Q9H1D9" "DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1" "0.000" "False" "51.568" "27" "8" "12" "8" "316" "35.7" "6.11" "35.77" "8" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05158" "10621" "ENSG00000132664" "POLR3F" "A8K4C7; hsa:10621; O15319; Q9H1D9" "Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "10" "0" "1.000" "0.968" "1.034" "1.006" "0.979" "0.999" "1.074" "0.953" "0.696" "966.1" "966.2" "935.4" "999.0" "971.7" "945.6" "964.9" "1037.7" "920.8" "672.4" "" "" "" "" "" "" "" "" "" "" "856.8" "800.3" "816.2" "747.1" "810.2" "868.6" "815.5" "857.7" "844.5" "672.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "51.568" "18" "9" "16" "7" "521" "55.9" "7.88" "57.82" "9" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "18" "2" "1.025" "1.017" "0.980" "0.934" "0.962" "0.907" "0.960" "0.937" "0.969" "1551.1" "1589.2" "1578.2" "1519.5" "1449.3" "1492.6" "1406.5" "1488.6" "1453.4" "1502.4" "" "" "" "" "" "" "" "" "" "" "1375.5" "1316.4" "1377.1" "1136.4" "1208.5" "1371.2" "1188.7" "1230.5" "1332.9" "1502.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "51.564" "26" "8" "11" "8" "342" "38.9" "5.52" "42.63" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "4" "0" "0.984" "0.919" "1.024" "0.973" "1.022" "0.998" "0.940" "0.944" "1.240" "1094.4" "1076.9" "1005.7" "1120.8" "1065.0" "1118.3" "1092.6" "1029.2" "1033.1" "1357.4" "" "" "" "" "" "" "" "" "" "" "970.5" "892.0" "877.5" "838.2" "888.1" "1027.3" "923.4" "850.7" "947.5" "1357.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307754887580196146" "False" "High" "IsMasterProtein" "Q13287" "N-myc-interactor OS=Homo sapiens OX=9606 GN=NMI PE=1 SV=2" "0.000" "False" "51.560" "38" "10" "10" "10" "307" "35.0" "5.34" "42.39" "10" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "9111" "ENSG00000123609" "NMI" "B5BU69; hsa:9111; Q13287; Q53TI8; Q8WTW2; Q9BVE5" "SARS-CoV-1 activates/modulates innate immune responses" "IL-2 signaling pathway" "2" "0" "1.024" "1.029" "1.065" "1.038" "1.035" "1.137" "1.141" "1.074" "0.515" "1585.0" "1623.4" "1630.9" "1688.6" "1645.6" "1640.3" "1802.7" "1809.1" "1702.5" "816.1" "" "" "" "" "" "" "" "" "" "" "1405.5" "1344.8" "1423.0" "1262.9" "1372.2" "1506.8" "1523.6" "1495.3" "1561.4" "816.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8867340794532680383" "False" "High" "IsMasterProtein" "O94967" "WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1" "0.000" "False" "51.542" "11" "9" "15" "9" "919" "101.9" "5.94" "46.66" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf17814" "22911" "ENSG00000085433" "WDR47" "A8MX09; hsa:22911; O94967; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9" "" "" "0" "0" "0.952" "0.971" "0.996" "0.984" "1.048" "0.958" "1.062" "1.042" "0.718" "1377.2" "1310.5" "1337.3" "1371.8" "1355.4" "1444.0" "1319.5" "1463.2" "1434.8" "988.9" "" "" "" "" "" "" "" "" "" "" "1221.3" "1085.6" "1166.9" "1025.9" "1130.2" "1326.5" "1115.2" "1209.4" "1315.9" "988.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5215276665585730267" "False" "High" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "0.000" "False" "51.531" "14" "6" "17" "6" "480" "50.4" "9.63" "70.21" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "mRNA Splicing - Major Pathway" "" "1" "0" "1.085" "1.040" "1.191" "1.147" "1.006" "1.124" "1.011" "0.993" "1.030" "841.1" "912.7" "874.8" "1001.8" "964.4" "846.5" "945.8" "850.4" "835.6" "866.0" "" "" "" "" "" "" "" "" "" "" "745.9" "756.1" "763.3" "749.2" "804.2" "777.6" "799.4" "702.9" "766.3" "866.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "51.528" "26" "8" "16" "8" "297" "33.3" "5.25" "61.17" "8" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "2" "0" "1.067" "1.031" "1.096" "1.011" "1.008" "1.041" "0.985" "0.954" "1.370" "1110.3" "1184.4" "1144.9" "1217.1" "1122.4" "1118.8" "1155.8" "1093.3" "1058.8" "1521.0" "" "" "" "" "" "" "" "" "" "" "984.6" "981.1" "999.0" "910.2" "936.0" "1027.8" "976.8" "903.7" "971.1" "1521.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "51.519" "17" "7" "14" "1" "376" "42.3" "6.40" "48.82" "7" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "Neutrophil degranulation; MHC class II antigen presentation" "" "2" "0" "0.892" "1.000" "0.926" "0.997" "1.020" "1.017" "0.916" "0.991" "0.871" "276.7" "246.7" "276.7" "256.3" "275.9" "282.2" "281.4" "253.4" "274.2" "240.9" "" "" "" "" "" "" "" "" "" "" "245.4" "204.3" "241.4" "191.6" "230.0" "259.2" "237.8" "209.5" "251.5" "240.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246140782840633700" "False" "High" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "0.000" "False" "51.486" "27" "9" "13" "8" "352" "38.4" "9.11" "45.50" "9" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "" "8" "0" "0.976" "0.981" "0.962" "0.943" "0.949" "1.012" "0.998" "1.022" "0.647" "2056.9" "2007.4" "2017.6" "1979.0" "1939.0" "1952.6" "2081.3" "2053.2" "2101.4" "1330.1" "" "" "" "" "" "" "" "" "" "" "1824.0" "1662.9" "1760.5" "1480.0" "1616.9" "1793.7" "1759.0" "1697.1" "1927.3" "1330.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7101780835120275737" "False" "High" "IsMasterProtein" "Q9Y3Q8" "TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2" "0.000" "False" "51.462" "19" "7" "11" "5" "395" "41.0" "7.21" "42.35" "7" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf01166" "81628" "ENSG00000166925" "TSC22D4" "A4D2C3; A8MWR6; D6W5V9; hsa:81628; Q9Y3Q8" "" "" "0" "0" "0.944" "0.936" "1.042" "0.940" "0.927" "0.969" "0.940" "0.940" "1.554" "643.4" "607.2" "602.2" "670.4" "604.7" "596.6" "623.3" "604.9" "605.1" "999.8" "" "" "" "" "" "" "" "" "" "" "570.6" "503.0" "525.5" "501.4" "504.2" "548.1" "526.8" "500.0" "555.0" "999.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3075207303668690710" "False" "High" "IsMasterProtein" "P37198" "Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3" "0.000" "False" "51.435" "15" "5" "7" "5" "522" "53.2" "5.31" "37.01" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05064" "23636" "ENSG00000213024" "NUP62" "B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1" "HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "7q11.23 copy number variation syndrome" "30" "0" "0.967" "1.026" "0.966" "1.006" "0.967" "0.956" "0.968" "0.978" "1.902" "675.5" "653.2" "692.9" "652.4" "679.7" "653.5" "645.7" "654.0" "660.8" "1284.6" "" "" "" "" "" "" "" "" "" "" "599.0" "541.1" "604.6" "487.9" "566.8" "600.3" "545.7" "540.5" "606.0" "1284.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "51.434" "25" "8" "13" "8" "326" "36.9" "5.97" "46.78" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "RNA polymerase II transcribes snRNA genes" "Modulators of TCR signaling and T cell activation" "2" "0" "1.013" "0.994" "0.876" "0.873" "0.901" "0.859" "0.836" "1.000" "3.152" "1682.5" "1703.7" "1672.1" "1473.8" "1468.3" "1516.5" "1445.6" "1406.3" "1682.0" "5302.9" "" "" "" "" "" "" "" "" "" "" "1492.0" "1411.2" "1459.0" "1102.2" "1224.4" "1393.1" "1221.7" "1162.4" "1542.6" "5302.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "51.361" "56" "8" "13" "8" "167" "18.8" "8.95" "50.96" "8" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "0.912" "0.993" "0.985" "0.969" "0.993" "0.957" "0.929" "0.946" "0.761" "1199.5" "1093.8" "1190.9" "1182.0" "1162.8" "1190.9" "1147.4" "1113.9" "1135.2" "912.4" "" "" "" "" "" "" "" "" "" "" "1063.7" "906.0" "1039.1" "884.0" "969.7" "1093.9" "969.7" "920.7" "1041.1" "912.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631666065222226929" "False" "High" "IsMasterProtein" "P42898" "Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3" "0.000" "False" "51.355" "15" "8" "9" "8" "656" "74.5" "5.34" "38.58" "8" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf02219" "4524" "ENSG00000177000" "MTHFR" "B2R7A6; hsa:4524; P42898; Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2" "Metabolism of folate and pterines" "Glycine metabolism; Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; MTHFR deficiency; Male infertility; Spina bifida" "14" "0" "1.023" "1.010" "1.016" "1.049" "1.080" "1.033" "1.088" "1.025" "0.844" "793.2" "811.2" "801.4" "806.1" "832.4" "856.3" "819.1" "862.6" "813.4" "669.6" "" "" "" "" "" "" "" "" "" "" "703.4" "671.9" "699.3" "602.8" "694.1" "786.6" "692.3" "713.0" "746.0" "669.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866024987760357114" "False" "High" "IsMasterProtein" "Q9Y2A7" "Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1" "0.000" "False" "51.259" "11" "11" "14" "11" "1128" "128.7" "6.62" "43.50" "11" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf09735" "10787" "ENSG00000061676" "NCKAP1" "hsa:10787; O60329; Q53QN5; Q53S94; Q53Y35; Q9Y2A7" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Exercise-induced circadian regulation; Regulation of actin cytoskeleton" "9" "0" "1.006" "1.053" "1.008" "1.074" "1.035" "1.006" "1.021" "0.978" "0.703" "897.5" "903.1" "944.9" "904.5" "964.3" "929.2" "903.2" "916.1" "877.8" "631.1" "" "" "" "" "" "" "" "" "" "" "795.9" "748.1" "824.5" "676.5" "804.1" "853.6" "763.4" "757.2" "805.1" "631.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.000" "False" "51.240" "30" "10" "15" "10" "349" "40.2" "5.20" "61.37" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "Eukaryotic transcription initiation" "10" "0" "0.985" "0.972" "1.013" "0.992" "0.924" "0.914" "0.926" "0.926" "0.813" "1045.6" "1030.2" "1016.1" "1058.7" "1037.1" "966.3" "955.4" "968.3" "967.9" "850.5" "" "" "" "" "" "" "" "" "" "" "927.2" "853.3" "886.6" "791.8" "864.8" "887.7" "807.5" "800.3" "887.7" "850.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "51.238" "20" "8" "11" "8" "521" "59.4" "7.72" "47.06" "8" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Erythrocytes take up carbon dioxide and release oxygen" "Oxidation by cytochrome P450" "2" "0" "1.099" "1.109" "1.199" "1.068" "1.056" "1.109" "1.060" "0.991" "0.782" "830.1" "912.2" "920.2" "994.9" "886.8" "876.9" "920.6" "880.1" "822.4" "649.0" "" "" "" "" "" "" "" "" "" "" "736.1" "755.6" "802.9" "744.1" "739.4" "805.6" "778.1" "727.5" "754.2" "649.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "51.188" "33" "7" "10" "7" "245" "26.7" "7.65" "42.21" "7" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "Synthesis of Ketone Bodies" "" "1" "0" "1.081" "1.081" "1.005" "0.970" "0.972" "0.825" "0.867" "0.900" "0.824" "1194.0" "1290.4" "1291.2" "1200.2" "1157.9" "1160.3" "984.9" "1034.8" "1075.1" "983.4" "" "" "" "" "" "" "" "" "" "" "1058.8" "1068.9" "1126.6" "897.6" "965.5" "1065.8" "832.4" "855.4" "986.1" "983.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2017615054723730630" "False" "High" "IsMasterProtein" "Q6N069" "N-alpha-acetyltransferase 16, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA16 PE=1 SV=2" "0.000" "False" "51.107" "8" "8" "28" "1" "864" "101.4" "7.87" "80.52" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf07719, Pf12569" "79612" "ENSG00000172766" "NAA16" "B0QZ59; hsa:79612; Q5VSP9; Q6N069; Q6P2D5; Q8N5J3; Q8N870" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "51.096" "14" "10" "13" "8" "765" "86.1" "7.08" "50.55" "10" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.087" "0.957" "1.080" "1.038" "0.981" "1.056" "0.830" "0.948" "3.205" "513.9" "558.6" "491.8" "555.2" "533.5" "503.9" "542.6" "426.5" "487.4" "1647.4" "" "" "" "" "" "" "" "" "" "" "455.8" "462.7" "429.1" "415.2" "444.9" "462.9" "458.6" "352.5" "447.0" "1647.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588374002070682198" "False" "High" "IsMasterProtein" "P63000" "Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1" "0.000" "False" "51.043" "34" "6" "29" "3" "192" "21.4" "8.50" "90.62" "6" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5879" "ENSG00000136238" "RAC1" "hsa:5879; O95501; P15154; P63000; Q3Y4D3; Q5JAA8; Q9BTB4" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; NRAGE signals death through JNK; MAPK6/MAPK4 signaling; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; Signaling by SCF-KIT; DAP12 signaling; Ephrin signaling; Factors involved in megakaryocyte development and platelet production; RHO GTPases activate CIT; PCP/CE pathway; WNT5:FZD7-mediated leishmania damping; EPH-ephrin mediated repulsion of cells; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signal transduction by L1; RHO GTPases activate PKNs; RHO GTPases activate PAKs; DSCAM interactions; Azathioprine ADME; VEGFR2 mediated vascular permeability; Sema4D mediated inhibition of cell attachment and migration; Inactivation of CDC42 and RAC1; Activation of RAC1; CD28 dependent Vav1 pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction; RHO GTPases Activate NADPH Oxidases; NTRK2 activates RAC1; MET activates RAP1 and RAC1; Activation of RAC1 downstream of NMDARs; Activated NTRK2 signals through CDK5; RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Target of rapamycin signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Cardiac hypertrophic response; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Robo4 and VEGF signaling pathways crosstalk; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Ciliary landscape; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Netrin-UNC5B signaling pathway; Insulin signaling; CAMKK2 pathway; Opioid receptor pathways; Regulation of actin cytoskeleton; GDNF signaling; 2q13 copy number variation syndrome; 2q21.1 copy number variation syndrome; 2q37 copy number variation syndrome; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "113" "0" "0.967" "1.007" "0.993" "1.057" "1.043" "0.989" "1.043" "1.042" "0.624" "1507.5" "1457.3" "1518.4" "1496.5" "1593.1" "1572.7" "1491.5" "1572.6" "1570.6" "941.1" "" "" "" "" "" "" "" "" "" "" "1336.8" "1207.2" "1324.9" "1119.2" "1328.4" "1444.7" "1260.6" "1299.9" "1440.5" "941.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "51.021" "31" "8" "16" "4" "226" "22.6" "10.92" "53.75" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "0.846" "0.857" "0.878" "0.805" "0.885" "0.836" "0.862" "0.784" "0.316" "860.5" "727.6" "737.1" "755.7" "692.4" "762.0" "719.5" "742.0" "675.0" "272.0" "" "" "" "" "" "" "" "" "" "" "763.1" "602.7" "643.1" "565.1" "577.3" "700.0" "608.1" "613.3" "619.1" "272.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.000" "False" "51.014" "30" "10" "13" "10" "398" "45.3" "8.90" "48.97" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "17" "0" "0.984" "0.993" "1.044" "0.990" "0.992" "1.149" "1.135" "1.118" "0.928" "936.2" "921.1" "929.6" "977.4" "926.5" "928.8" "1076.1" "1062.7" "1047.1" "869.1" "" "" "" "" "" "" "" "" "" "" "830.2" "763.0" "811.1" "730.9" "772.6" "853.2" "909.5" "878.4" "960.3" "869.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2886709730536475345" "False" "High" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "0.000" "False" "50.865" "26" "5" "11" "5" "268" "30.7" "3.85" "39.30" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "1.065" "1.111" "1.111" "1.077" "0.958" "1.070" "0.827" "0.893" "3.991" "670.6" "714.4" "745.2" "744.7" "722.3" "642.4" "717.3" "554.7" "598.9" "2675.9" "" "" "" "" "" "" "" "" "" "" "594.6" "591.7" "650.2" "556.9" "602.3" "590.1" "606.2" "458.5" "549.3" "2675.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "50.835" "35" "6" "16" "6" "205" "22.3" "5.17" "63.06" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "Signaling by NODAL; Signaling by Activin" "" "2" "0" "0.988" "1.003" "0.975" "0.969" "1.005" "0.943" "0.978" "1.002" "0.560" "2828.5" "2794.6" "2835.8" "2758.8" "2740.0" "2843.0" "2668.0" "2766.3" "2833.1" "1585.0" "" "" "" "" "" "" "" "" "" "" "2508.2" "2314.9" "2474.4" "2063.2" "2284.8" "2611.6" "2254.9" "2286.5" "2598.3" "1585.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "50.789" "43" "8" "18" "8" "136" "14.6" "10.04" "68.59" "8" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "" "2" "0" "0.963" "1.135" "0.918" "0.991" "0.997" "0.983" "1.049" "1.070" "0.521" "3329.0" "3207.2" "3778.2" "3056.0" "3298.5" "3320.5" "3272.6" "3493.7" "3563.2" "1734.4" "" "" "" "" "" "" "" "" "" "" "2952.1" "2656.7" "3296.7" "2285.5" "2750.5" "3050.3" "2765.9" "2887.8" "3267.9" "1734.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752338987200815694" "False" "High" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "0.000" "False" "50.777" "31" "6" "13" "6" "235" "25.2" "7.59" "56.68" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.098" "1.034" "1.099" "1.085" "1.000" "1.056" "1.093" "1.084" "0.460" "1272.1" "1396.3" "1315.8" "1397.8" "1380.0" "1272.3" "1343.3" "1390.2" "1378.6" "584.7" "" "" "" "" "" "" "" "" "" "" "1128.1" "1156.6" "1148.1" "1045.4" "1150.7" "1168.7" "1135.3" "1149.1" "1264.4" "584.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4293780430971367314" "False" "High" "IsMasterProtein" "Q13371" "Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3" "0.000" "False" "50.763" "31" "8" "10" "8" "301" "34.3" "4.73" "37.67" "8" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf02114" "5082" "ENSG00000136940" "PDCL" "hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" "" "1" "0" "1.086" "0.998" "1.043" "1.017" "0.954" "1.101" "0.907" "0.925" "1.470" "658.6" "715.5" "657.1" "687.0" "670.0" "628.0" "725.0" "597.1" "609.2" "967.9" "" "" "" "" "" "" "" "" "" "" "584.0" "592.7" "573.3" "513.8" "558.7" "576.9" "612.7" "493.5" "558.7" "967.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.000" "False" "50.598" "16" "6" "10" "6" "540" "56.5" "5.52" "41.77" "6" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; PKR-mediated signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Ovarian tumor domain proteases" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "24" "0" "1.009" "1.115" "1.034" "1.040" "1.034" "1.059" "1.066" "1.082" "0.627" "719.6" "726.3" "802.5" "744.4" "748.1" "744.2" "761.9" "766.9" "778.7" "451.0" "" "" "" "" "" "" "" "" "" "" "638.2" "601.6" "700.2" "556.7" "623.8" "683.6" "643.9" "633.9" "714.2" "451.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5798091253452066801" "False" "High" "IsMasterProtein" "Cont_Q86YZ3" "Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2" "0.000" "True" "50.592" "9" "9" "12" "9" "2850" "282.2" "10.04" "44.57" "9" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01023" "388697" "ENSG00000197915" "HRNR" "hsa:388697; Q5DT20; Q5U1F4; Q86YZ3" "Neutrophil degranulation" "" "1" "0" "0.842" "0.953" "2.518" "4.161" "1.425" "0.846" "0.490" "1.318" "1.527" "104.9" "88.3" "100.0" "264.0" "436.3" "149.4" "88.7" "51.4" "138.2" "160.2" "" "" "" "" "" "" "" "" "" "" "93.0" "73.1" "87.2" "197.4" "363.8" "137.2" "75.0" "42.5" "126.7" "160.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "50.513" "44" "7" "30" "7" "201" "23.3" "5.29" "118.17" "7" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "Rev-mediated nuclear export of HIV RNA" "22q11.2 copy number variation syndrome" "2" "0" "0.950" "0.955" "1.004" "0.944" "0.961" "1.000" "1.034" "1.016" "1.023" "3965.3" "3767.5" "3786.8" "3979.6" "3744.6" "3809.6" "3966.9" "4100.5" "4026.9" "4057.8" "" "" "" "" "" "" "" "" "" "" "3516.4" "3120.8" "3304.2" "2976.2" "3122.5" "3499.5" "3352.6" "3389.4" "3693.2" "4057.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "High" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.000" "False" "50.503" "26" "8" "11" "8" "349" "40.3" "5.57" "45.69" "8" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "Cellular response to hypoxia" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "3" "0" "1.039" "0.977" "0.975" "1.018" "1.130" "0.991" "1.017" "0.938" "0.753" "919.7" "955.8" "898.4" "897.0" "936.0" "1039.5" "911.8" "935.4" "862.3" "692.8" "" "" "" "" "" "" "" "" "" "" "815.6" "791.8" "783.9" "670.8" "780.5" "954.9" "770.6" "773.2" "790.9" "692.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "50.491" "34" "7" "20" "7" "217" "25.1" "6.15" "70.84" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "33" "0" "1.099" "1.106" "1.016" "1.209" "1.121" "1.213" "1.283" "1.280" "1.279" "2387.3" "2623.3" "2640.8" "2425.5" "2886.8" "2677.2" "2895.7" "3061.8" "3055.5" "3052.3" "" "" "" "" "" "" "" "" "" "" "2117.0" "2173.0" "2304.3" "1814.0" "2407.2" "2459.3" "2447.3" "2530.8" "2802.3" "3052.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8612473288009054962" "False" "High" "IsMasterProtein" "Q16626" "Male-enhanced antigen 1 OS=Homo sapiens OX=9606 GN=MEA1 PE=1 SV=2" "0.000" "False" "50.482" "16" "2" "9" "2" "185" "19.9" "4.22" "41.77" "2" "developmental processes;other biological processes" "other cell component" "" "Pf06910" "4201" "ENSG00000124733" "MEA1" "hsa:4201; Q16626; Q5TC36; Q9BV01" "" "" "0" "0" "0.940" "0.929" "1.016" "0.951" "0.957" "0.996" "0.987" "0.993" "0.527" "1147.5" "1078.7" "1065.7" "1165.8" "1091.4" "1097.8" "1142.6" "1132.7" "1139.9" "604.9" "" "" "" "" "" "" "" "" "" "" "1017.6" "893.6" "929.9" "871.9" "910.1" "1008.4" "965.7" "936.3" "1045.5" "604.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106414634070186016" "False" "High" "IsMasterProtein" "Q8WVM8" "Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4" "0.000" "False" "50.472" "19" "10" "12" "10" "642" "72.3" "6.27" "42.33" "10" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00995" "23256" "ENSG00000092108" "SCFD1" "A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8" "COPII-mediated vesicle transport; RHOA GTPase cycle" "" "2" "0" "0.974" "0.825" "0.938" "0.744" "0.747" "0.951" "0.669" "0.979" "4.913" "561.2" "546.7" "463.0" "526.4" "417.3" "419.1" "533.5" "375.6" "549.3" "2757.2" "" "" "" "" "" "" "" "" "" "" "497.7" "452.8" "404.0" "393.7" "348.0" "385.0" "450.9" "310.5" "503.8" "2757.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.000" "False" "50.464" "37" "4" "8" "4" "153" "17.2" "8.22" "39.64" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "0.968" "0.952" "1.004" "0.992" "0.982" "1.044" "0.969" "0.970" "1.071" "866.5" "838.7" "824.8" "869.7" "859.9" "851.2" "904.4" "839.7" "840.5" "927.6" "" "" "" "" "" "" "" "" "" "" "768.4" "694.7" "719.7" "650.4" "717.0" "781.9" "764.3" "694.0" "770.9" "927.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "50.448" "42" "7" "14" "7" "185" "20.1" "5.22" "45.48" "7" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "1.036" "0.971" "1.026" "0.992" "0.922" "0.941" "0.889" "0.910" "0.608" "1075.4" "1114.5" "1044.5" "1103.1" "1067.3" "991.7" "1011.5" "955.6" "978.6" "654.2" "" "" "" "" "" "" "" "" "" "" "953.7" "923.2" "911.4" "825.0" "890.0" "910.9" "854.9" "789.9" "897.5" "654.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "50.435" "14" "8" "10" "8" "669" "73.4" "7.77" "38.25" "8" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "8" "0" "0.967" "0.925" "0.974" "0.973" "1.049" "0.985" "0.863" "1.002" "4.243" "804.0" "777.8" "743.8" "782.9" "782.6" "843.5" "791.6" "693.8" "805.9" "3411.7" "" "" "" "" "" "" "" "" "" "" "713.0" "644.3" "649.0" "585.5" "652.6" "774.8" "669.0" "573.4" "739.2" "3411.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "High" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.000" "False" "50.427" "19" "8" "10" "5" "505" "54.5" "7.88" "41.26" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "Heme signaling; NGF-stimulated transcription; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "36" "3" "0.981" "0.874" "0.922" "0.841" "0.913" "0.898" "0.862" "0.908" "0.658" "1660.2" "1628.7" "1451.3" "1531.3" "1396.3" "1515.7" "1490.4" "1430.5" "1507.1" "1093.1" "" "" "" "" "" "" "" "" "" "" "1472.2" "1349.1" "1266.4" "1145.2" "1164.3" "1392.4" "1259.7" "1182.4" "1382.2" "1093.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449077897622524501" "False" "High" "IsMasterProtein" "O95551" "Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1" "0.000" "False" "50.365" "19" "5" "7" "5" "362" "40.9" "5.10" "35.95" "5" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf14555" "51567" "ENSG00000111802" "TDP2" "B4DKL8; B4DQ95; O95551; Q2TBE2; Q5JYM0; Q7Z6U5; Q9NUK5; Q9NYY9" "Nonhomologous End-Joining (NHEJ)" "Oxidative damage response" "2" "0" "1.004" "0.870" "1.044" "1.003" "0.941" "1.032" "0.986" "0.938" "1.984" "799.0" "802.4" "695.0" "834.2" "801.4" "752.1" "824.6" "787.5" "749.1" "1585.5" "" "" "" "" "" "" "" "" "" "" "708.6" "664.7" "606.5" "623.9" "668.2" "690.9" "696.9" "650.9" "687.0" "1585.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7610728054593455927" "False" "High" "IsMasterProtein" "Q86SZ2" "Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1" "0.000" "False" "50.361" "62" "11" "18" "11" "158" "18.0" "8.68" "62.53" "11" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "122553" "ENSG00000182400" "TRAPPC6B" "B3KPS2; hsa:122553; Q5JPD6; Q86SZ2; Q86U35; Q86X35" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.052" "1.100" "1.109" "1.101" "1.115" "1.126" "1.119" "1.040" "0.648" "1733.0" "1823.6" "1905.9" "1922.6" "1908.2" "1932.0" "1951.6" "1938.9" "1801.8" "1122.3" "" "" "" "" "" "" "" "" "" "" "1536.8" "1510.6" "1663.0" "1437.8" "1591.2" "1774.7" "1649.4" "1602.7" "1652.5" "1122.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "50.316" "27" "7" "15" "7" "221" "25.5" "11.85" "55.54" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "1.053" "1.058" "1.043" "1.046" "1.008" "1.050" "1.115" "1.188" "0.707" "1394.7" "1468.7" "1476.3" "1454.2" "1458.8" "1406.0" "1464.9" "1555.5" "1657.1" "986.2" "" "" "" "" "" "" "" "" "" "" "1236.8" "1216.6" "1288.2" "1087.6" "1216.4" "1291.6" "1238.1" "1285.7" "1519.8" "986.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "50.312" "28" "10" "20" "10" "365" "41.3" "8.68" "65.99" "10" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "" "Mesodermal commitment pathway" "1" "0" "1.042" "0.927" "0.902" "0.903" "0.893" "0.875" "0.782" "0.881" "1.792" "1275.6" "1328.8" "1182.0" "1150.6" "1152.3" "1138.7" "1116.3" "997.6" "1124.2" "2285.3" "" "" "" "" "" "" "" "" "" "" "1131.2" "1100.7" "1031.4" "860.5" "960.9" "1046.0" "943.5" "824.6" "1031.1" "2285.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "50.294" "51" "5" "26" "5" "100" "10.7" "9.60" "95.24" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "0.861" "0.747" "0.764" "0.673" "0.660" "0.686" "0.740" "0.769" "0.363" "6557.7" "5647.7" "4895.5" "5008.5" "4411.9" "4328.2" "4499.9" "4850.4" "5040.4" "2381.1" "" "" "" "" "" "" "" "" "" "" "5815.3" "4678.3" "4271.5" "3745.7" "3678.9" "3975.9" "3803.1" "4009.2" "4622.7" "2381.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "50.291" "24" "6" "14" "6" "263" "29.6" "10.15" "49.60" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.131" "1.073" "1.190" "1.162" "0.840" "1.096" "1.041" "1.107" "2.111" "608.8" "688.7" "653.4" "724.3" "707.6" "511.3" "667.4" "633.6" "673.9" "1285.0" "" "" "" "" "" "" "" "" "" "" "539.9" "570.5" "570.1" "541.7" "590.0" "469.7" "564.0" "523.7" "618.1" "1285.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2054594351010378030" "False" "High" "IsMasterProtein" "Q9H977" "WD repeat-containing protein 54 OS=Homo sapiens OX=9606 GN=WDR54 PE=1 SV=1" "0.000" "False" "50.249" "27" "6" "7" "6" "334" "35.9" "6.20" "35.91" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf21031" "84058" "ENSG00000005448" "WDR54" "B9A049; D6W5I3; hsa:84058; Q53H85; Q86V45; Q9H977" "" "" "0" "0" "1.069" "1.070" "1.206" "1.043" "1.061" "1.097" "1.035" "0.964" "0.879" "470.0" "502.6" "502.9" "567.0" "490.4" "498.7" "515.8" "486.5" "453.0" "412.9" "" "" "" "" "" "" "" "" "" "" "416.8" "416.3" "438.8" "424.1" "408.9" "458.1" "435.9" "402.2" "415.5" "412.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "50.215" "26" "11" "13" "11" "451" "49.7" "6.05" "54.13" "11" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "mRNA Splicing - Major Pathway" "" "1" "0" "0.940" "0.890" "0.864" "0.831" "0.823" "0.791" "0.862" "0.893" "0.730" "2606.0" "2449.2" "2320.1" "2252.1" "2164.6" "2144.4" "2060.5" "2245.4" "2326.0" "1901.6" "" "" "" "" "" "" "" "" "" "" "2311.0" "2028.8" "2024.4" "1684.3" "1805.0" "1969.8" "1741.5" "1855.9" "2133.2" "1901.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "50.201" "17" "15" "15" "15" "862" "99.2" "5.01" "49.23" "15" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "TBC/RABGAPs" "GDNF signaling" "2" "0" "0.973" "0.963" "0.884" "0.845" "1.001" "0.839" "0.810" "0.967" "1.993" "1361.7" "1324.4" "1311.5" "1203.2" "1151.3" "1363.4" "1142.1" "1103.3" "1316.9" "2713.4" "" "" "" "" "" "" "" "" "" "" "1207.5" "1097.1" "1144.3" "899.9" "960.0" "1252.5" "965.2" "912.0" "1207.7" "2713.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "50.197" "45" "9" "13" "9" "223" "26.0" "4.98" "53.87" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "Unwinding of DNA" "" "1" "0" "1.052" "1.078" "0.970" "1.047" "1.005" "1.113" "1.090" "1.205" "1.584" "732.3" "770.3" "789.7" "710.4" "766.6" "735.8" "815.3" "798.5" "882.2" "1159.8" "" "" "" "" "" "" "" "" "" "" "649.4" "638.0" "689.0" "531.3" "639.2" "675.9" "689.1" "660.0" "809.1" "1159.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548420804533655280" "False" "High" "IsMasterProtein" "O43353" "Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2" "0.000" "False" "50.178" "19" "10" "14" "10" "540" "61.2" "7.09" "50.06" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00619, Pf07714" "8767" "ENSG00000104312" "RIPK2" "B7Z748; hsa:8767; O43353; Q6UWF0" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor signaling pathway" "13" "0" "1.001" "1.063" "0.987" "0.996" "1.049" "1.038" "0.972" "1.032" "0.803" "826.7" "827.2" "878.9" "816.1" "823.1" "867.6" "858.0" "803.7" "853.6" "663.5" "" "" "" "" "" "" "" "" "" "" "733.1" "685.2" "766.9" "610.4" "686.4" "797.0" "725.2" "664.3" "782.9" "663.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "50.119" "20" "11" "16" "11" "548" "61.1" "7.36" "53.93" "11" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine salvage" "Pyrimidine metabolism" "2" "0" "1.083" "0.957" "1.085" "1.072" "1.032" "1.167" "1.147" "1.059" "0.976" "971.5" "1051.7" "929.5" "1053.9" "1041.0" "1002.2" "1133.7" "1114.1" "1029.2" "948.5" "" "" "" "" "" "" "" "" "" "" "861.5" "871.2" "811.0" "788.2" "868.1" "920.6" "958.2" "920.9" "943.9" "948.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "50.074" "24" "6" "11" "6" "289" "32.8" "7.09" "44.68" "6" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.075" "0.936" "1.244" "1.162" "1.019" "1.124" "1.122" "0.911" "0.455" "1027.2" "1104.6" "961.3" "1278.2" "1193.6" "1047.1" "1154.2" "1152.2" "936.0" "467.5" "" "" "" "" "" "" "" "" "" "" "910.9" "915.0" "838.8" "956.0" "995.3" "961.9" "975.5" "952.3" "858.5" "467.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6685402705848511390" "False" "High" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "0.000" "False" "50.070" "25" "8" "17" "8" "318" "35.9" "7.11" "56.95" "8" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00117, Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Neutrophil degranulation" "Fluoropyrimidine activity" "2" "0" "1.006" "1.032" "0.950" "1.047" "1.112" "1.026" "1.072" "1.040" "0.529" "2526.0" "2541.5" "2607.9" "2399.3" "2643.9" "2808.8" "2592.5" "2707.3" "2626.7" "1335.3" "" "" "" "" "" "" "" "" "" "" "2240.0" "2105.2" "2275.5" "1794.3" "2204.6" "2580.2" "2191.0" "2237.8" "2409.1" "1335.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "50.020" "25" "6" "16" "6" "209" "23.4" "8.24" "60.92" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "1.022" "1.020" "1.067" "1.028" "0.949" "1.026" "1.012" "0.943" "0.773" "2211.9" "2260.3" "2256.7" "2359.9" "2272.9" "2099.0" "2268.5" "2239.1" "2086.3" "1709.4" "" "" "" "" "" "" "" "" "" "" "1961.5" "1872.3" "1969.1" "1764.9" "1895.3" "1928.2" "1917.3" "1850.8" "1913.5" "1709.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677934760849169098" "False" "High" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "0.000" "False" "49.978" "28" "10" "14" "10" "418" "46.5" "9.29" "53.40" "10" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "" "4" "0" "1.057" "1.096" "1.155" "1.110" "1.128" "1.165" "1.132" "1.118" "0.582" "1312.6" "1386.8" "1438.8" "1515.9" "1456.6" "1480.6" "1528.6" "1485.6" "1467.8" "764.6" "" "" "" "" "" "" "" "" "" "" "1164.0" "1148.7" "1255.4" "1133.7" "1214.6" "1360.1" "1292.0" "1227.9" "1346.2" "764.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "49.947" "51" "8" "16" "8" "160" "18.0" "5.01" "59.16" "8" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "1.035" "1.015" "0.954" "1.007" "1.096" "1.005" "1.005" "1.012" "0.601" "1854.3" "1919.9" "1881.9" "1769.5" "1866.7" "2032.5" "1864.4" "1863.2" "1876.8" "1114.3" "" "" "" "" "" "" "" "" "" "" "1644.3" "1590.3" "1642.1" "1323.3" "1556.6" "1867.0" "1575.7" "1540.0" "1721.3" "1114.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "49.904" "13" "11" "13" "11" "835" "95.3" "7.05" "42.35" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "0" "1.002" "0.904" "1.091" "1.005" "0.961" "1.168" "1.006" "1.089" "3.366" "902.4" "904.6" "816.0" "984.3" "906.7" "867.3" "1054.2" "908.0" "982.3" "3037.2" "" "" "" "" "" "" "" "" "" "" "800.2" "749.3" "712.0" "736.1" "756.1" "796.7" "891.0" "750.5" "900.9" "3037.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "49.854" "69" "9" "15" "9" "110" "12.4" "8.41" "52.14" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.947" "0.981" "0.863" "0.920" "1.020" "0.853" "0.913" "0.929" "0.333" "2375.4" "2249.7" "2331.1" "2048.8" "2184.4" "2423.6" "2025.9" "2169.1" "2207.9" "790.0" "" "" "" "" "" "" "" "" "" "" "2106.4" "1863.5" "2034.0" "1532.2" "1821.5" "2226.3" "1712.2" "1792.9" "2024.9" "790.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480523710602738279" "False" "High" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "0.000" "False" "49.829" "61" "5" "10" "5" "127" "15.0" "4.12" "52.53" "5" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "1.001" "0.972" "0.911" "0.922" "0.964" "1.005" "0.976" "1.012" "0.922" "1620.9" "1622.6" "1574.8" "1476.1" "1494.4" "1562.5" "1629.1" "1582.5" "1640.9" "1494.1" "" "" "" "" "" "" "" "" "" "" "1437.4" "1344.0" "1374.1" "1104.0" "1246.2" "1435.3" "1376.9" "1308.1" "1505.0" "1494.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "49.824" "19" "9" "14" "9" "463" "50.3" "7.42" "47.31" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "Citric acid cycle (TCA cycle)" "" "1" "0" "0.978" "0.869" "1.243" "1.044" "0.896" "1.664" "1.229" "1.356" "4.950" "751.9" "735.4" "653.2" "934.7" "784.8" "673.5" "1250.8" "923.9" "1019.5" "3722.0" "" "" "" "" "" "" "" "" "" "" "666.7" "609.1" "570.0" "699.0" "654.4" "618.6" "1057.2" "763.7" "935.0" "3722.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "49.618" "31" "11" "14" "11" "349" "38.7" "5.78" "47.65" "11" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "1.027" "0.997" "1.011" "1.006" "1.040" "1.019" "1.004" "0.986" "0.545" "1780.1" "1827.9" "1774.4" "1799.8" "1791.1" "1851.4" "1814.3" "1786.4" "1755.4" "969.5" "" "" "" "" "" "" "" "" "" "" "1578.5" "1514.2" "1548.2" "1346.0" "1493.5" "1700.7" "1533.4" "1476.6" "1610.0" "969.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "49.594" "36" "4" "17" "4" "143" "14.8" "8.63" "65.04" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.970" "0.966" "0.976" "0.972" "0.946" "1.056" "0.979" "0.992" "0.653" "660.7" "640.9" "638.0" "644.8" "642.3" "625.0" "697.4" "646.5" "655.1" "431.2" "" "" "" "" "" "" "" "" "" "" "585.9" "530.9" "556.7" "482.2" "535.6" "574.1" "589.4" "534.4" "600.8" "431.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4363739394428502664" "False" "High" "IsMasterProtein" "O75330" "Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2" "0.000" "False" "49.538" "19" "14" "17" "13" "724" "84.0" "5.83" "52.36" "14" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15905, Pf15908" "3161" "ENSG00000072571" "HMMR" "A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0; hsa:3161; O75330; Q32N02; Q92767" "AURKA Activation by TPX2; Hyaluronan uptake and degradation" "" "2" "0" "1.012" "0.943" "1.109" "1.043" "0.945" "1.064" "0.654" "0.890" "6.105" "754.0" "763.1" "711.0" "836.1" "786.5" "712.3" "802.4" "493.2" "671.1" "4603.4" "" "" "" "" "" "" "" "" "" "" "668.6" "632.1" "620.4" "625.3" "655.8" "654.3" "678.2" "407.7" "615.5" "4603.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9194827022255966282" "False" "High" "IsMasterProtein" "Q9C0J8" "pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2" "0.000" "False" "49.477" "8" "9" "19" "9" "1336" "145.8" "9.17" "52.75" "9" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf01391" "55339" "ENSG00000136709" "WDR33" "hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "" "5" "0" "0.968" "0.979" "0.920" "0.976" "0.940" "0.956" "0.927" "0.939" "0.691" "565.4" "547.5" "553.8" "520.3" "551.6" "531.3" "540.4" "524.3" "530.8" "390.5" "" "" "" "" "" "" "" "" "" "" "501.4" "453.5" "483.2" "389.1" "460.0" "488.0" "456.7" "433.3" "486.8" "390.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "49.462" "14" "7" "11" "7" "600" "67.6" "8.06" "45.60" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "0.970" "0.979" "1.088" "1.024" "0.956" "0.957" "1.048" "0.966" "0.699" "900.7" "873.3" "881.7" "980.1" "921.9" "861.4" "861.8" "944.0" "870.3" "629.6" "" "" "" "" "" "" "" "" "" "" "798.7" "723.4" "769.3" "732.9" "768.7" "791.3" "728.3" "780.3" "798.1" "629.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3870745537767616027" "False" "High" "IsMasterProtein" "Q9UKT9" "Zinc finger protein Aiolos OS=Homo sapiens OX=9606 GN=IKZF3 PE=1 SV=2" "0.000" "False" "49.460" "25" "11" "13" "7" "509" "58.0" "6.55" "46.58" "11" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "22806" "ENSG00000161405" "IKZF3" "B4DVV5; hsa:22806; Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; Q8WWQ9; Q8WWR0; Q8WWR1; Q8WWR2; Q8WWR3; Q9UKT9" "" "17q12 copy number variation syndrome" "1" "4" "0.986" "0.984" "0.928" "0.891" "0.888" "0.794" "0.721" "0.862" "3.000" "1070.3" "1054.8" "1052.9" "993.3" "953.4" "950.6" "849.5" "771.4" "923.1" "3211.3" "" "" "" "" "" "" "" "" "" "" "949.1" "873.8" "918.7" "742.9" "795.0" "873.2" "717.9" "637.6" "846.6" "3211.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "49.449" "38" "8" "24" "8" "201" "22.8" "7.02" "77.65" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.014" "1.020" "1.060" "1.046" "1.038" "1.053" "1.063" "0.993" "0.518" "2472.4" "2508.1" "2521.3" "2620.6" "2586.6" "2566.6" "2603.4" "2627.2" "2455.7" "1280.4" "" "" "" "" "" "" "" "" "" "" "2192.5" "2077.6" "2199.9" "1959.9" "2156.9" "2357.8" "2200.3" "2171.6" "2252.2" "1280.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "49.385" "46" "7" "23" "7" "156" "17.7" "10.45" "76.95" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.937" "0.985" "0.971" "0.985" "0.938" "0.979" "0.948" "0.946" "0.510" "3478.4" "3260.8" "3427.1" "3378.0" "3427.1" "3261.1" "3405.6" "3299.0" "3289.8" "1774.8" "" "" "" "" "" "" "" "" "" "" "3084.6" "2701.1" "2990.3" "2526.3" "2857.8" "2995.7" "2878.3" "2726.8" "3017.2" "1774.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "49.328" "25" "8" "10" "8" "412" "45.5" "6.42" "39.10" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "1.107" "1.071" "1.030" "1.048" "1.042" "0.915" "0.768" "0.940" "3.445" "629.0" "696.3" "673.9" "648.1" "659.0" "655.3" "575.2" "483.0" "591.5" "2167.0" "" "" "" "" "" "" "" "" "" "" "557.8" "576.8" "588.0" "484.7" "549.5" "602.0" "486.2" "399.2" "542.5" "2167.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-684970281821863116" "False" "High" "IsMasterProtein" "Q9BXW9" "Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2" "0.000" "False" "49.270" "7" "10" "12" "10" "1451" "164.0" "5.88" "40.68" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14631" "2177" "ENSG00000144554" "FANCD2" "hsa:2177; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9BXW9; Q9H9T9" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "miRNA regulation of DNA damage response; 15q13.3 copy number variation syndrome; DNA repair pathways, full network; 15q11q13 copy number variation; DNA damage response" "7" "0" "1.006" "0.858" "0.939" "0.840" "0.852" "0.932" "0.649" "0.835" "4.451" "1061.0" "1067.3" "910.8" "996.7" "891.1" "903.4" "988.8" "688.1" "886.1" "4722.6" "" "" "" "" "" "" "" "" "" "" "940.9" "884.1" "794.7" "745.4" "743.1" "829.9" "835.7" "568.7" "812.7" "4722.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "49.212" "36" "7" "16" "7" "184" "20.5" "5.92" "54.53" "7" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "mTORC1-mediated signalling; Macroautophagy; Regulation of PTEN gene transcription; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "26" "0" "0.989" "0.872" "0.948" "0.926" "0.848" "0.882" "0.974" "0.901" "0.615" "1493.3" "1477.3" "1301.6" "1415.8" "1383.0" "1265.7" "1317.6" "1454.4" "1345.2" "918.6" "" "" "" "" "" "" "" "" "" "" "1324.3" "1223.8" "1135.7" "1058.8" "1153.2" "1162.7" "1113.6" "1202.2" "1233.7" "918.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.000" "False" "49.207" "18" "12" "14" "12" "639" "73.4" "6.20" "48.83" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "Lung fibrosis" "4" "0" "1.075" "1.070" "1.119" "1.068" "1.059" "0.999" "0.887" "0.980" "2.467" "1132.7" "1217.3" "1212.5" "1267.1" "1209.8" "1199.5" "1131.6" "1004.2" "1110.6" "2794.4" "" "" "" "" "" "" "" "" "" "" "1004.4" "1008.4" "1058.0" "947.6" "1008.8" "1101.9" "956.4" "830.1" "1018.5" "2794.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710541814749781042" "False" "High" "IsMasterProtein" "P54619" "5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1" "0.000" "False" "49.205" "27" "8" "9" "8" "331" "37.6" "6.92" "41.26" "8" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00571" "5571" "ENSG00000181929" "PRKAG1" "B4DDT7; hsa:5571; P54619; Q8N7V9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "24" "0" "1.007" "0.973" "1.057" "1.029" "1.059" "1.065" "1.069" "0.950" "1.060" "797.8" "803.0" "776.5" "843.0" "820.6" "844.8" "849.7" "853.1" "758.2" "845.9" "" "" "" "" "" "" "" "" "" "" "707.4" "665.2" "677.5" "630.5" "684.3" "776.1" "718.1" "705.2" "695.3" "845.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.000" "False" "49.149" "39" "7" "17" "7" "169" "19.6" "9.51" "53.30" "7" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "8" "0" "0.983" "0.986" "0.999" "1.008" "0.964" "0.901" "1.007" "1.008" "0.475" "1946.3" "1912.3" "1918.1" "1943.6" "1962.6" "1876.0" "1754.6" "1959.1" "1962.1" "923.9" "" "" "" "" "" "" "" "" "" "" "1725.9" "1584.1" "1673.7" "1453.6" "1636.6" "1723.3" "1482.9" "1619.3" "1799.5" "923.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8461791288305677895" "False" "High" "IsMasterProtein" "Q92783" "Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3" "0.000" "False" "49.104" "16" "8" "12" "6" "540" "59.1" "4.82" "48.56" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "8027" "ENSG00000136738" "STAM" "B0YJ99; D3DRU5; hsa:8027; Q8N6D9; Q92783" "Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Metalloprotease DUBs; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "Vitamin D receptor pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "11" "0" "1.050" "1.059" "1.002" "1.054" "1.018" "1.009" "1.009" "1.006" "0.889" "1243.6" "1305.4" "1316.8" "1246.1" "1311.1" "1265.8" "1254.5" "1254.5" "1250.8" "1105.7" "" "" "" "" "" "" "" "" "" "" "1102.8" "1081.3" "1149.0" "931.9" "1093.3" "1162.8" "1060.3" "1036.9" "1147.2" "1105.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4718065310323386899" "False" "High" "IsMasterProtein" "Q5VSL9" "Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1" "0.000" "False" "49.102" "14" "8" "9" "8" "837" "95.5" "6.29" "35.48" "8" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf07923, Pf11882" "85369" "ENSG00000143093" "STRIP1" "hsa:85369; Q0V925; Q5VSL8; Q5VSL9; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2" "" "" "0" "0" "1.065" "0.976" "1.176" "0.995" "1.010" "1.023" "0.955" "0.828" "0.986" "512.3" "545.4" "499.9" "602.4" "509.9" "517.3" "523.9" "489.1" "424.0" "505.3" "" "" "" "" "" "" "" "" "" "" "454.3" "451.8" "436.2" "450.5" "425.2" "475.2" "442.8" "404.3" "388.9" "505.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "49.096" "54" "6" "23" "5" "121" "13.4" "7.24" "82.71" "6" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "MASTL Facilitates Mitotic Progression" "" "1" "2" "0.986" "1.014" "0.942" "1.005" "1.063" "0.966" "1.012" "1.021" "0.555" "2459.2" "2425.0" "2493.0" "2316.4" "2471.5" "2614.3" "2376.6" "2489.5" "2511.0" "1365.3" "" "" "" "" "" "" "" "" "" "" "2180.7" "2008.8" "2175.2" "1732.4" "2060.9" "2401.5" "2008.6" "2057.7" "2302.9" "1365.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "49.064" "10" "9" "11" "8" "1001" "113.6" "6.29" "43.03" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "E3 ubiquitin ligases ubiquitinate target proteins" "ATM signaling in development and disease" "2" "0" "1.051" "0.977" "0.990" "0.904" "1.011" "0.881" "0.781" "1.086" "4.581" "255.4" "268.4" "249.6" "252.8" "230.7" "258.2" "225.0" "199.4" "277.2" "1169.9" "" "" "" "" "" "" "" "" "" "" "226.5" "222.3" "217.8" "189.1" "192.4" "237.2" "190.1" "164.8" "254.2" "1169.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3644173202538667698" "False" "High" "IsMasterProtein" "Q9Y4B6" "DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3" "0.000" "False" "49.039" "8" "14" "14" "14" "1507" "168.9" "5.06" "46.03" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "" "9730" "ENSG00000145041" "DCAF1" "hsa:9730; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; Q9Y4B6" "Antigen processing: Ubiquitination & Proteasome degradation" "Hippo-Merlin signaling dysregulation" "2" "0" "0.947" "0.947" "1.109" "0.932" "0.861" "0.889" "0.788" "0.848" "1.769" "1029.6" "974.7" "975.3" "1141.7" "959.7" "886.8" "915.9" "811.2" "873.5" "1821.8" "" "" "" "" "" "" "" "" "" "" "913.1" "807.4" "851.0" "853.8" "800.2" "814.7" "774.0" "670.5" "801.1" "1821.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "49.032" "36" "7" "13" "7" "197" "22.5" "7.99" "45.16" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "Gastric cancer network 2" "3" "0" "1.030" "0.956" "0.976" "1.024" "1.004" "1.048" "0.997" "1.040" "2.947" "749.8" "772.0" "717.0" "731.9" "767.8" "753.0" "786.0" "747.4" "780.0" "2210.0" "" "" "" "" "" "" "" "" "" "" "664.9" "639.5" "625.6" "547.3" "640.3" "691.7" "664.3" "617.8" "715.4" "2210.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "49.027" "50" "6" "37" "6" "86" "10.1" "7.97" "117.96" "6" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "0.891" "0.926" "0.884" "0.895" "0.896" "0.879" "0.918" "0.902" "0.437" "5633.7" "5022.3" "5217.2" "4980.6" "5044.9" "5048.6" "4949.6" "5169.7" "5080.5" "2459.4" "" "" "" "" "" "" "" "" "" "" "4995.8" "4160.2" "4552.2" "3724.8" "4206.8" "4637.7" "4183.2" "4273.1" "4659.5" "2459.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "49.019" "15" "8" "13" "8" "552" "62.0" "8.31" "44.36" "8" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "Glycosaminoglycan degradation" "5" "0" "1.100" "1.032" "1.076" "1.043" "1.059" "1.043" "1.040" "0.989" "0.582" "1059.7" "1166.0" "1093.4" "1139.8" "1105.0" "1122.2" "1105.3" "1102.0" "1047.6" "616.6" "" "" "" "" "" "" "" "" "" "" "939.7" "965.8" "954.0" "852.4" "921.4" "1030.9" "934.1" "910.9" "960.8" "616.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8476150003951297336" "False" "High" "IsMasterProtein" "Q96KG9" "N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1" "0.000" "False" "49.000" "13" "10" "13" "10" "808" "89.6" "6.30" "47.67" "10" "stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "57410" "ENSG00000142186" "SCYL1" "A6NJF1; hsa:57410; Q96G50; Q96KG8; Q96KG9; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53" "" "" "0" "0" "1.047" "1.019" "1.001" "1.022" "0.932" "1.035" "0.979" "0.948" "1.629" "1021.9" "1069.5" "1041.0" "1023.4" "1044.1" "952.2" "1057.2" "999.9" "968.4" "1664.4" "" "" "" "" "" "" "" "" "" "" "906.2" "885.9" "908.4" "765.4" "870.6" "874.7" "893.5" "826.5" "888.1" "1664.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "48.967" "18" "6" "11" "5" "359" "40.6" "4.89" "45.57" "6" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "" "Initiation of transcription and translation elongation at the HIV-1 LTR" "1" "1" "1.004" "1.001" "1.009" "1.028" "1.073" "1.046" "1.032" "1.068" "0.611" "1212.6" "1216.8" "1214.0" "1223.1" "1246.7" "1301.0" "1268.7" "1251.8" "1294.6" "740.4" "" "" "" "" "" "" "" "" "" "" "1075.3" "1008.0" "1059.3" "914.7" "1039.6" "1195.1" "1072.2" "1034.7" "1187.3" "740.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "48.955" "29" "10" "13" "10" "368" "42.0" "8.63" "45.31" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "0.948" "0.936" "0.928" "1.000" "0.966" "1.028" "1.043" "1.004" "0.816" "785.1" "743.9" "735.1" "728.9" "784.9" "758.6" "807.1" "819.1" "787.9" "640.9" "" "" "" "" "" "" "" "" "" "" "696.2" "616.3" "641.4" "545.1" "654.5" "696.8" "682.1" "677.1" "722.6" "640.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670278986062403757" "False" "High" "IsMasterProtein" "P17050" "Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2" "0.000" "False" "48.933" "24" "8" "10" "8" "411" "46.5" "5.19" "37.40" "8" "other metabolic processes" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf16499, Pf17450" "4668" "ENSG00000198951" "NAGA" "hsa:4668; P17050" "" "" "0" "0" "1.039" "1.037" "1.113" "1.023" "1.085" "1.050" "1.079" "1.109" "0.515" "651.2" "676.6" "675.5" "724.5" "665.8" "706.7" "683.6" "702.7" "722.0" "335.6" "" "" "" "" "" "" "" "" "" "" "577.4" "560.4" "589.4" "541.8" "555.2" "649.2" "577.7" "580.8" "662.2" "335.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8205136122998856932" "False" "High" "IsMasterProtein" "P60981" "Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3" "0.000" "False" "48.913" "42" "8" "25" "6" "165" "18.5" "7.85" "75.21" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00241" "11034" "ENSG00000125868" "DSTN" "B2R6N2; B4DYA6; hsa:11034; P18282; P60981; Q5W166; Q6IAW2" "" "Androgen receptor signaling pathway" "1" "0" "1.024" "1.128" "1.006" "1.042" "1.100" "1.071" "1.020" "1.061" "0.701" "1661.0" "1700.4" "1873.6" "1671.1" "1730.3" "1827.5" "1779.5" "1694.6" "1762.9" "1164.7" "" "" "" "" "" "" "" "" "" "" "1472.9" "1408.5" "1634.8" "1249.8" "1442.8" "1678.8" "1504.0" "1400.7" "1616.8" "1164.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5329658274444496515" "False" "High" "IsMasterProtein" "O95394" "Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1" "0.000" "False" "48.876" "20" "10" "12" "10" "542" "59.8" "6.25" "47.97" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00408, Pf02878, Pf21404, Pf21405" "5238" "ENSG00000013375" "PGM3" "B2RB65; B4DX94; D6RF12; E1P547; E9PF86; hsa:5238; O95394; Q5JWR4; Q96J46; Q9H8G5; Q9NS94; Q9NTT6; Q9UFV5; Q9UIY2" "Synthesis of UDP-N-acetyl-glucosamine" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "3" "0" "0.936" "0.941" "0.926" "0.910" "0.886" "0.987" "0.962" "1.049" "1.294" "1151.3" "1077.1" "1083.7" "1065.6" "1047.9" "1020.4" "1136.1" "1108.1" "1207.8" "1490.0" "" "" "" "" "" "" "" "" "" "" "1020.9" "892.2" "945.6" "796.9" "873.8" "937.4" "960.2" "915.9" "1107.7" "1490.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "48.851" "34" "7" "16" "6" "191" "21.2" "6.55" "64.82" "7" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "RAC1 GTPase cycle; RHO GTPases Activate Formins; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; MAPK6/MAPK4 signaling; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHOU GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; Myogenesis; Factors involved in megakaryocyte development and platelet production; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "63" "1" "1.064" "1.137" "0.911" "1.148" "1.061" "1.010" "0.970" "1.079" "1.018" "2508.4" "2670.1" "2853.0" "2284.3" "2880.5" "2662.2" "2533.9" "2433.8" "2705.7" "2554.2" "" "" "" "" "" "" "" "" "" "" "2224.4" "2211.8" "2489.4" "1708.3" "2401.9" "2445.5" "2141.6" "2011.7" "2481.5" "2554.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728646887416176304" "False" "High" "IsMasterProtein" "Q8IYL3" "UPF0688 protein C1orf174 OS=Homo sapiens OX=9606 GN=C1orf174 PE=1 SV=2" "0.000" "False" "48.696" "30" "5" "10" "5" "243" "26.0" "6.90" "39.87" "5" "" "nucleus" "" "Pf15772" "339448" "ENSG00000198912" "C1orf174" "A8K0C8; A8MUG9; hsa:339448; Q5SR20; Q6NX36; Q8IYL3" "" "" "0" "0" "0.937" "1.019" "0.949" "0.945" "1.025" "0.895" "1.067" "1.001" "0.723" "907.3" "850.3" "924.5" "860.8" "857.8" "929.9" "811.5" "968.1" "908.0" "656.0" "" "" "" "" "" "" "" "" "" "" "804.5" "704.3" "806.7" "643.8" "715.3" "854.3" "685.9" "800.2" "832.8" "656.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1907773996049463670" "False" "High" "IsMasterProtein" "O43504" "Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1" "0.000" "False" "48.685" "81" "4" "7" "4" "91" "9.6" "4.87" "34.72" "4" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf16672" "10542" "ENSG00000134248" "LAMTOR5" "A0A0C4DGV4; hsa:10542; O43504; Q6IBD8" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "" "7" "0" "0.894" "0.874" "0.958" "0.956" "1.000" "0.984" "1.034" "1.098" "0.531" "216.9" "193.9" "189.4" "207.8" "207.3" "216.9" "213.4" "224.2" "238.2" "115.3" "" "" "" "" "" "" "" "" "" "" "192.3" "160.7" "165.3" "155.4" "172.9" "199.3" "180.3" "185.3" "218.4" "115.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "48.612" "5" "11" "12" "11" "2376" "266.8" "7.11" "43.03" "11" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "1.058" "0.966" "1.039" "0.978" "0.976" "1.000" "0.828" "1.006" "3.332" "1058.5" "1120.3" "1022.8" "1099.4" "1035.5" "1033.5" "1058.0" "876.9" "1065.0" "3526.6" "" "" "" "" "" "" "" "" "" "" "938.7" "928.0" "892.5" "822.2" "863.5" "949.4" "894.2" "724.8" "976.8" "3526.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3970443704612931563" "False" "High" "IsMasterProtein" "P36578" "Large ribosomal subunit protein uL4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "0.000" "False" "48.601" "25" "10" "12" "10" "427" "47.7" "11.06" "42.55" "10" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.171" "1.052" "1.262" "1.174" "1.033" "1.011" "1.046" "1.062" "1.005" "929.1" "1088.4" "977.1" "1172.2" "1090.3" "959.9" "939.2" "971.9" "986.7" "933.6" "" "" "" "" "" "" "" "" "" "" "823.9" "901.6" "852.6" "876.7" "909.2" "881.8" "793.7" "803.3" "905.0" "933.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "48.596" "36" "8" "22" "4" "198" "22.4" "6.68" "62.29" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "" "Sterol regulatory element-binding proteins (SREBP) signaling" "1" "4" "1.009" "1.039" "0.916" "1.029" "0.947" "0.974" "0.982" "1.048" "0.721" "2108.8" "2127.6" "2190.8" "1931.6" "2170.9" "1997.8" "2054.5" "2070.8" "2210.7" "1521.0" "" "" "" "" "" "" "" "" "" "" "1870.0" "1762.4" "1911.6" "1444.6" "1810.3" "1835.2" "1736.4" "1711.7" "2027.5" "1521.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "48.574" "14" "11" "16" "11" "938" "102.9" "7.02" "50.39" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "0.972" "0.921" "0.973" "0.904" "0.953" "0.963" "0.626" "0.907" "6.032" "685.6" "666.7" "631.6" "667.0" "619.8" "653.1" "660.6" "429.1" "622.0" "4135.8" "" "" "" "" "" "" "" "" "" "" "608.0" "552.3" "551.1" "498.9" "516.9" "599.9" "558.3" "354.7" "570.5" "4135.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "48.553" "10" "12" "12" "12" "1269" "144.7" "6.05" "43.61" "12" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.023" "0.933" "0.983" "0.923" "0.933" "1.027" "0.803" "1.107" "5.984" "821.1" "839.7" "766.0" "806.9" "758.0" "766.3" "843.3" "659.3" "908.7" "4913.0" "" "" "" "" "" "" "" "" "" "" "728.1" "695.6" "668.4" "603.5" "632.1" "704.0" "712.7" "545.0" "833.4" "4913.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3676506683142235675" "False" "High" "IsMasterProtein" "Q9NZN3" "EH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=EHD3 PE=1 SV=2" "0.000" "False" "48.547" "16" "9" "16" "1" "535" "60.8" "6.57" "63.17" "9" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30845" "ENSG00000013016" "EHD3" "B4DFR5; D6W574; hsa:30845; Q8N514; Q9NZB3; Q9NZN3" "Factors involved in megakaryocyte development and platelet production" "Ciliary landscape" "2" "0" "0.922" "0.958" "1.263" "1.053" "1.009" "1.012" "0.964" "0.945" "0.716" "114.3" "105.3" "109.5" "144.3" "120.3" "115.3" "115.6" "110.1" "107.9" "81.7" "" "" "" "" "" "" "" "" "" "" "101.3" "87.2" "95.5" "107.9" "100.3" "105.9" "97.7" "91.0" "99.0" "81.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893850793131937072" "False" "High" "IsMasterProtein" "O95749" "Geranylgeranyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=GGPS1 PE=1 SV=1" "0.000" "False" "48.513" "26" "8" "12" "8" "300" "34.8" "6.14" "41.38" "8" "other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00348" "9453" "ENSG00000152904" "GGPS1" "A8MVQ8; hsa:9453; O95749; Q5T2C8; Q6NW19" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis pathway in hepatocytes" "4" "0" "0.996" "1.058" "1.020" "1.059" "1.130" "1.060" "1.190" "1.160" "0.590" "1378.9" "1373.6" "1458.5" "1406.6" "1460.9" "1558.7" "1461.4" "1641.6" "1599.6" "814.1" "" "" "" "" "" "" "" "" "" "" "1222.8" "1137.8" "1272.6" "1052.0" "1218.2" "1431.8" "1235.1" "1356.9" "1467.0" "814.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "48.449" "33" "9" "15" "9" "288" "31.7" "7.66" "50.72" "9" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "Nicotinamide salvaging" "" "1" "0" "1.001" "1.098" "1.017" "1.107" "1.111" "1.074" "1.142" "1.113" "0.544" "1007.0" "1007.9" "1105.5" "1023.8" "1115.0" "1118.3" "1081.4" "1149.7" "1121.1" "547.6" "" "" "" "" "" "" "" "" "" "" "893.0" "834.9" "964.6" "765.7" "929.7" "1027.3" "913.9" "950.3" "1028.2" "547.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-577333653668623519" "False" "High" "IsMasterProtein" "Q9HAD4" "WD repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=WDR41 PE=1 SV=3" "0.000" "False" "48.442" "21" "8" "8" "8" "459" "51.7" "5.44" "33.10" "8" "other metabolic processes;other biological processes" "other cell component" "" "Pf00400" "55255" "ENSG00000164253" "WDR41" "B4DT55; hsa:55255; Q7Z792; Q8IWG3; Q8IXA9; Q8NDA7; Q9HAD4; Q9NV62" "" "" "0" "0" "1.082" "1.020" "1.149" "1.150" "1.022" "1.092" "1.076" "0.954" "0.746" "1183.2" "1280.3" "1207.4" "1358.9" "1360.6" "1209.8" "1291.8" "1273.7" "1128.7" "883.1" "" "" "" "" "" "" "" "" "" "" "1049.2" "1060.5" "1053.5" "1016.3" "1134.5" "1111.3" "1091.8" "1052.8" "1035.1" "883.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723353511819689268" "False" "High" "IsMasterProtein" "Q92947" "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" "0.000" "False" "48.423" "14" "6" "10" "6" "438" "48.1" "8.06" "38.36" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "2639" "ENSG00000105607" "GCDH" "A8K2Z2; O14719; Q92947" "Lysine catabolism" "Fatty acid beta-oxidation; Tryptophan metabolism" "3" "0" "0.946" "0.845" "0.953" "0.918" "0.826" "0.962" "1.019" "1.056" "0.673" "641.6" "607.0" "541.9" "611.4" "588.7" "530.0" "617.4" "653.8" "677.7" "431.8" "" "" "" "" "" "" "" "" "" "" "569.0" "502.8" "472.8" "457.2" "490.9" "486.9" "521.8" "540.4" "621.6" "431.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "48.396" "47" "12" "13" "12" "250" "28.7" "8.75" "44.03" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.959" "0.891" "0.914" "0.876" "0.886" "0.986" "0.875" "0.926" "2.802" "941.4" "903.0" "838.6" "860.5" "824.3" "834.3" "928.4" "823.9" "872.0" "2638.1" "" "" "" "" "" "" "" "" "" "" "834.8" "748.0" "731.7" "643.5" "687.4" "766.4" "784.6" "681.0" "799.8" "2638.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "High" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.000" "False" "48.395" "49" "8" "20" "8" "170" "19.5" "5.30" "74.46" "8" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "4" "0" "1.031" "1.051" "1.037" "1.036" "0.995" "0.978" "0.984" "0.958" "0.749" "1505.4" "1551.8" "1582.7" "1561.6" "1559.5" "1497.8" "1472.8" "1481.9" "1442.7" "1126.9" "" "" "" "" "" "" "" "" "" "" "1334.9" "1285.4" "1381.0" "1167.9" "1300.4" "1375.9" "1244.7" "1224.9" "1323.2" "1126.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6627286514823912553" "False" "High" "IsMasterProtein" "Q8TEA1" "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 OS=Homo sapiens OX=9606 GN=NSUN6 PE=1 SV=1" "0.000" "False" "48.369" "25" "10" "11" "10" "469" "51.7" "7.96" "37.35" "10" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "221078" "ENSG00000241058" "NSUN6" "B0YJ54; hsa:221078; Q8TEA1" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.035" "1.003" "1.026" "1.059" "1.049" "1.006" "1.021" "1.025" "1.015" "873.6" "903.8" "876.5" "896.1" "925.4" "916.5" "878.7" "892.4" "895.1" "886.7" "" "" "" "" "" "" "" "" "" "" "774.7" "748.7" "764.8" "670.1" "771.7" "841.9" "742.7" "737.6" "820.9" "886.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7424972638177503000" "False" "High" "IsMasterProtein" "Q5T1C6" "Acyl-coenzyme A thioesterase THEM4 OS=Homo sapiens OX=9606 GN=THEM4 PE=1 SV=1" "0.000" "False" "48.319" "31" "7" "12" "7" "240" "27.1" "8.28" "50.47" "7" "cell organization and biogenesis;other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf03061" "117145" "ENSG00000159445" "THEM4" "B2RBX2; hsa:117145; Q5T1C6; Q96KR2" "Mitochondrial Fatty Acid Beta-Oxidation; CD28 dependent PI3K/Akt signaling; Activation of AKT2; VEGFR2 mediated vascular permeability; Negative regulation of the PI3K/AKT network" "PI3K-Akt signaling pathway" "7" "0" "1.039" "1.024" "1.029" "1.072" "1.050" "1.083" "1.111" "1.021" "0.522" "1374.9" "1429.1" "1407.8" "1415.3" "1474.0" "1444.1" "1488.8" "1527.2" "1403.2" "717.4" "" "" "" "" "" "" "" "" "" "" "1219.3" "1183.8" "1228.4" "1058.5" "1229.1" "1326.5" "1258.3" "1262.3" "1286.9" "717.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7544877575899964257" "False" "High" "IsMasterProtein" "Q96C57" "Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2" "0.000" "False" "48.211" "31" "7" "10" "7" "262" "28.2" "9.42" "41.13" "7" "cell-cell signaling;signal transduction;other biological processes" "nucleus" "" "" "64897" "ENSG00000157895" "CUSTOS" "Q53HF0; Q96C57; Q9H9Z7" "" "" "0" "0" "0.982" "0.965" "1.050" "1.098" "0.953" "0.959" "1.081" "1.055" "0.273" "818.5" "804.0" "789.6" "859.4" "899.0" "780.0" "785.1" "885.1" "863.5" "223.5" "" "" "" "" "" "" "" "" "" "" "725.8" "666.0" "689.0" "642.7" "749.6" "716.5" "663.6" "731.6" "791.9" "223.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "48.201" "18" "11" "14" "11" "763" "82.9" "9.04" "48.16" "11" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "1.053" "0.970" "1.159" "1.031" "0.989" "1.165" "0.789" "1.052" "5.700" "341.0" "359.2" "330.7" "395.1" "351.4" "337.2" "397.4" "268.9" "358.8" "1943.4" "" "" "" "" "" "" "" "" "" "" "302.4" "297.5" "288.6" "295.5" "293.0" "309.7" "335.9" "222.3" "329.0" "1943.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8467787264096672406" "False" "High" "IsMasterProtein" "O00506" "Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1" "0.000" "False" "48.149" "15" "6" "12" "2" "426" "48.1" "6.74" "44.35" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "10494" "ENSG00000115694" "STK25" "A8K6Z3; A8K7D2; B7Z9K1; hsa:10494; O00506; Q15522; Q5BJF1" "" "2q37 copy number variation syndrome" "1" "0" "1.146" "1.054" "1.245" "1.179" "1.042" "1.533" "1.365" "1.521" "1.788" "100.7" "115.3" "106.1" "125.4" "118.7" "104.9" "154.3" "137.4" "153.1" "180.0" "" "" "" "" "" "" "" "" "" "" "89.3" "95.5" "92.6" "93.7" "98.9" "96.4" "130.4" "113.5" "140.4" "180.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "High" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.000" "False" "48.087" "13" "13" "13" "13" "981" "112.3" "5.22" "40.56" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling" "" "3" "0" "0.999" "0.912" "1.046" "0.921" "0.860" "1.009" "0.654" "0.836" "5.960" "538.4" "537.9" "491.1" "563.1" "495.9" "463.1" "543.2" "352.3" "450.4" "3208.9" "" "" "" "" "" "" "" "" "" "" "477.5" "445.6" "428.5" "421.1" "413.5" "425.4" "459.1" "291.2" "413.0" "3208.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "High" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.000" "False" "48.081" "32" "5" "12" "5" "170" "19.3" "4.81" "48.88" "5" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "15" "0" "0.917" "0.933" "0.890" "0.913" "0.982" "0.911" "0.915" "0.938" "0.589" "2276.9" "2087.5" "2123.9" "2025.6" "2079.8" "2236.7" "2073.3" "2082.5" "2135.9" "1341.8" "" "" "" "" "" "" "" "" "" "" "2019.1" "1729.2" "1853.2" "1514.9" "1734.3" "2054.6" "1752.2" "1721.3" "1958.9" "1341.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.000" "False" "48.077" "21" "6" "11" "6" "304" "34.7" "8.53" "42.62" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "1.049" "0.966" "0.985" "0.955" "1.012" "0.955" "0.930" "0.953" "0.916" "883.2" "926.4" "853.4" "869.8" "843.3" "894.2" "843.3" "821.3" "841.8" "809.0" "" "" "" "" "" "" "" "" "" "" "783.2" "767.4" "744.6" "650.5" "703.2" "821.4" "712.7" "678.8" "772.0" "809.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-767357545140157834" "False" "High" "IsMasterProtein" "P51784" "Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3" "0.000" "False" "48.076" "12" "10" "13" "10" "963" "109.7" "5.45" "42.01" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "" "ENSG00000102226" "USP11" "B2RTX1; P51784; Q8IUG6; Q9BWE1" "Ub-specific processing proteases; Association of TriC/CCT with target proteins during biosynthesis" "" "2" "0" "1.187" "1.037" "1.165" "1.092" "0.974" "1.159" "0.601" "0.967" "9.934" "638.3" "757.8" "661.9" "743.3" "696.7" "622.0" "739.7" "383.5" "616.9" "6340.5" "" "" "" "" "" "" "" "" "" "" "566.0" "627.7" "577.5" "555.9" "581.0" "571.4" "625.2" "317.0" "565.8" "6340.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6935074334363071802" "False" "High" "IsMasterProtein" "O00762" "Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1" "0.000" "False" "48.026" "50" "6" "8" "6" "179" "19.6" "7.37" "35.57" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "11065" "ENSG00000175063" "UBE2C" "A6NP33; E1P5N7; G3XAB7; hsa:11065; O00762" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Gastric cancer network 1; Gastric cancer network 2" "21" "0" "1.129" "1.025" "1.034" "1.099" "1.001" "0.859" "0.738" "0.886" "2.604" "743.3" "839.0" "761.8" "768.3" "816.6" "744.0" "638.7" "548.8" "658.6" "1935.8" "" "" "" "" "" "" "" "" "" "" "659.1" "695.0" "664.7" "574.6" "681.0" "683.5" "539.8" "453.6" "604.0" "1935.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7748730165992048021" "False" "High" "IsMasterProtein" "Q6UWE0" "E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1" "0.000" "False" "47.992" "16" "11" "13" "11" "723" "83.5" "5.94" "44.72" "11" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf07647, Pf13855, Pf13920" "90678" "ENSG00000148356" "LRSAM1" "Q5VVV0; Q6UWE0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7" "Antigen processing: Ubiquitination & Proteasome degradation" "Intracellular trafficking proteins involved in CMT neuropathy" "2" "0" "1.022" "1.003" "1.072" "0.962" "0.941" "0.983" "0.995" "0.960" "1.945" "665.2" "680.1" "667.3" "713.3" "639.7" "625.6" "653.6" "661.9" "638.3" "1294.0" "" "" "" "" "" "" "" "" "" "" "589.9" "563.3" "582.2" "533.4" "533.4" "574.7" "552.4" "547.1" "585.4" "1294.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3570886289104636423" "False" "High" "IsMasterProtein" "Q9NYP9" "Protein Mis18-alpha OS=Homo sapiens OX=9606 GN=MIS18A PE=1 SV=1" "0.000" "False" "47.948" "42" "9" "13" "9" "233" "25.8" "5.20" "49.73" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03226" "54069" "ENSG00000159055" "MIS18A" "B2R562; hsa:54069; Q542Z0; Q9NYP9" "Deposition of new CENPA-containing nucleosomes at the centromere" "" "1" "0" "0.950" "0.901" "0.858" "0.864" "0.933" "0.985" "0.972" "1.024" "0.752" "1719.8" "1633.0" "1549.1" "1476.4" "1485.5" "1604.0" "1694.3" "1672.3" "1761.4" "1293.7" "" "" "" "" "" "" "" "" "" "" "1525.1" "1352.7" "1351.7" "1104.1" "1238.7" "1473.4" "1431.9" "1382.3" "1615.5" "1293.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "47.923" "52" "8" "21" "8" "167" "19.3" "6.51" "71.98" "8" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "0.953" "0.975" "0.974" "0.963" "0.998" "0.944" "0.983" "0.951" "0.532" "1263.0" "1203.7" "1231.0" "1230.2" "1216.0" "1260.2" "1191.7" "1241.9" "1200.8" "671.8" "" "" "" "" "" "" "" "" "" "" "1120.0" "997.1" "1074.1" "920.0" "1014.0" "1157.6" "1007.2" "1026.6" "1101.3" "671.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "47.858" "25" "10" "13" "10" "432" "47.4" "6.70" "41.73" "10" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.134" "1.118" "1.084" "1.140" "1.040" "0.896" "0.924" "0.903" "0.393" "828.7" "939.6" "926.8" "898.1" "944.6" "862.0" "742.4" "765.5" "748.4" "325.8" "" "" "" "" "" "" "" "" "" "" "734.9" "778.3" "808.7" "671.7" "787.7" "791.8" "627.4" "632.7" "686.4" "325.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2572043715436263453" "False" "High" "IsMasterProtein" "Q9H3R5" "Centromere protein H OS=Homo sapiens OX=9606 GN=CENPH PE=1 SV=1" "0.000" "False" "47.842" "23" "5" "7" "5" "247" "28.5" "5.29" "25.75" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "other molecular function" "Pf05837" "64946" "ENSG00000153044" "CENPH" "A8K3Y1; hsa:64946; Q9H3R5" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "" "7" "0" "1.059" "1.045" "1.050" "1.056" "1.103" "1.004" "0.896" "1.032" "2.751" "452.0" "478.7" "472.3" "474.6" "477.4" "498.7" "453.9" "405.1" "466.4" "1243.3" "" "" "" "" "" "" "" "" "" "" "400.8" "396.5" "412.1" "354.9" "398.1" "458.1" "383.6" "334.9" "427.8" "1243.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.000" "False" "47.776" "12" "7" "8" "6" "729" "77.8" "6.79" "33.06" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "5" "1" "1.046" "0.978" "1.062" "1.017" "1.018" "1.002" "0.896" "0.960" "1.298" "423.5" "443.1" "414.1" "449.6" "430.7" "431.0" "424.1" "379.5" "406.6" "549.5" "" "" "" "" "" "" "" "" "" "" "375.5" "367.1" "361.3" "336.3" "359.1" "396.0" "358.4" "313.7" "372.9" "549.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "High" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.000" "False" "47.754" "14" "11" "12" "11" "846" "94.8" "8.78" "41.72" "11" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "0.958" "0.962" "1.018" "1.043" "0.966" "1.060" "1.005" "1.045" "0.923" "632.5" "605.7" "608.5" "644.1" "659.5" "610.8" "670.3" "635.4" "661.2" "583.9" "" "" "" "" "" "" "" "" "" "" "560.8" "501.7" "531.0" "481.7" "550.0" "561.1" "566.5" "525.2" "606.4" "583.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2670793063602377093" "False" "High" "IsMasterProtein" "Q8TBZ6" "tRNA methyltransferase 10 homolog A OS=Homo sapiens OX=9606 GN=TRMT10A PE=1 SV=1" "0.000" "False" "47.744" "30" "9" "25" "9" "339" "39.7" "7.65" "63.17" "9" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01746" "93587" "ENSG00000145331" "TRMT10A" "B2R8X7; hsa:93587; Q8TBZ6; Q9Y2T9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.962" "0.887" "0.911" "0.871" "0.886" "0.862" "0.912" "0.886" "0.757" "1635.7" "1574.1" "1450.0" "1490.4" "1424.3" "1448.8" "1410.2" "1491.7" "1449.1" "1239.0" "" "" "" "" "" "" "" "" "" "" "1450.5" "1303.9" "1265.2" "1114.6" "1187.6" "1330.8" "1191.9" "1233.0" "1329.0" "1239.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "47.741" "31" "7" "10" "6" "261" "29.3" "6.70" "40.99" "7" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Pyrimidine salvage" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "0" "1.067" "0.988" "1.092" "1.113" "1.055" "1.111" "1.082" "1.108" "0.830" "959.3" "1023.2" "947.4" "1047.8" "1067.3" "1011.9" "1065.9" "1037.9" "1063.2" "796.1" "" "" "" "" "" "" "" "" "" "" "850.7" "847.5" "826.7" "783.6" "890.0" "929.5" "900.8" "857.9" "975.1" "796.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "47.724" "24" "8" "9" "8" "357" "37.5" "5.45" "32.34" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "1.058" "0.971" "1.061" "0.979" "0.973" "0.929" "0.753" "0.926" "4.898" "942.5" "997.3" "915.0" "999.6" "923.0" "917.0" "875.8" "709.7" "872.4" "4616.1" "" "" "" "" "" "" "" "" "" "" "835.8" "826.1" "798.4" "747.6" "769.6" "842.4" "740.2" "586.6" "800.1" "4616.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345660777743534482" "False" "High" "IsMasterProtein" "Q9NPJ6" "Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1" "0.000" "False" "47.686" "34" "8" "11" "8" "270" "29.7" "5.10" "44.17" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10018" "29079" "ENSG00000136146" "MED4" "B4DX67; hsa:29079; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95; Q9NPJ6; Q9NYR5" "PPARA activates gene expression; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "4" "0" "1.042" "1.048" "1.097" "1.055" "1.109" "1.098" "1.067" "1.019" "0.835" "937.0" "976.4" "982.2" "1028.2" "988.8" "1038.9" "1028.5" "999.5" "954.4" "782.7" "" "" "" "" "" "" "" "" "" "" "830.9" "808.8" "857.0" "769.0" "824.6" "954.4" "869.2" "826.1" "875.3" "782.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.000" "False" "47.646" "17" "11" "14" "11" "620" "71.6" "5.85" "53.20" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.070" "1.087" "1.053" "1.071" "1.059" "1.041" "1.009" "0.998" "1.330" "1492.0" "1596.8" "1621.8" "1571.3" "1597.7" "1580.6" "1553.0" "1504.7" "1488.6" "1983.6" "" "" "" "" "" "" "" "" "" "" "1323.0" "1322.7" "1415.1" "1175.1" "1332.3" "1452.0" "1312.6" "1243.7" "1365.2" "1983.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "47.618" "19" "11" "11" "11" "630" "70.9" "8.09" "44.31" "11" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "SARS-CoV-1 activates/modulates innate immune responses; ISG15 antiviral mechanism; Interferon gamma signaling; RSV-host interactions; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "19" "0" "1.143" "0.926" "1.112" "1.012" "1.100" "1.055" "0.719" "0.931" "6.761" "478.0" "546.2" "442.5" "531.5" "483.5" "525.7" "504.5" "343.6" "444.8" "3231.6" "" "" "" "" "" "" "" "" "" "" "423.9" "452.5" "386.1" "397.5" "403.2" "482.9" "426.4" "284.0" "408.0" "3231.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1787588940823929001" "False" "High" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "0.000" "False" "47.572" "34" "6" "12" "2" "184" "20.8" "5.78" "45.54" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling" "26" "2" "1.010" "0.980" "0.952" "1.054" "1.041" "1.011" "0.985" "1.197" "0.584" "1137.8" "1149.1" "1115.0" "1083.0" "1198.9" "1184.4" "1150.2" "1121.2" "1362.2" "664.5" "" "" "" "" "" "" "" "" "" "" "1009.0" "951.8" "972.9" "809.9" "999.7" "1088.0" "972.1" "926.8" "1249.3" "664.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "47.542" "22" "3" "21" "3" "179" "19.1" "5.50" "81.78" "3" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "1.079" "1.016" "1.111" "1.006" "1.089" "1.130" "1.013" "0.969" "0.529" "1706.0" "1840.2" "1733.7" "1895.2" "1716.0" "1857.6" "1927.5" "1728.0" "1652.3" "902.2" "" "" "" "" "" "" "" "" "" "" "1512.9" "1524.3" "1512.8" "1417.4" "1430.9" "1706.4" "1629.1" "1428.3" "1515.4" "902.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "47.492" "55" "6" "7" "6" "150" "17.1" "4.68" "36.73" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "0.937" "0.923" "1.029" "0.969" "0.956" "0.954" "0.959" "0.804" "1.038" "668.2" "626.2" "617.1" "687.5" "647.6" "639.1" "637.8" "640.6" "537.2" "693.6" "" "" "" "" "" "" "" "" "" "" "592.6" "518.7" "538.4" "514.1" "540.0" "587.0" "539.0" "529.5" "492.7" "693.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9152525013652249776" "False" "High" "IsMasterProtein" "Q9H999" "Pantothenate kinase 3 OS=Homo sapiens OX=9606 GN=PANK3 PE=1 SV=1" "0.000" "False" "47.455" "26" "10" "11" "5" "370" "41.1" "6.55" "39.42" "10" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf03630" "79646" "ENSG00000120137" "PANK3" "D3DQL1; hsa:79646; Q53FJ9; Q7RTX4; Q9H999" "Coenzyme A biosynthesis" "" "1" "3" "1.020" "1.038" "1.002" "1.105" "1.138" "1.167" "1.126" "1.054" "0.830" "807.5" "823.5" "838.0" "809.1" "892.4" "918.8" "942.4" "909.3" "850.7" "670.3" "" "" "" "" "" "" "" "" "" "" "716.0" "682.2" "731.2" "605.1" "744.1" "844.1" "796.4" "751.6" "780.2" "670.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.000" "False" "47.432" "11" "12" "14" "12" "1023" "112.8" "5.49" "47.55" "12" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "6" "0" "1.176" "0.968" "1.102" "1.113" "1.057" "1.108" "1.067" "1.547" "0.774" "1221.3" "1436.4" "1182.5" "1345.6" "1358.8" "1291.0" "1353.0" "1302.8" "1889.2" "945.7" "" "" "" "" "" "" "" "" "" "" "1083.0" "1189.9" "1031.8" "1006.3" "1133.1" "1185.9" "1143.5" "1076.9" "1732.7" "945.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993927886623036395" "False" "High" "IsMasterProtein" "P31947" "14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1" "0.000" "False" "47.411" "33" "8" "84" "4" "248" "27.8" "4.74" "243.67" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "2810" "ENSG00000175793" "SFN" "hsa:2810; P31947; Q6FH30; Q6FH51; Q96DH0" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest" "miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; p53 transcriptional gene network; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; DNA damage response" "16" "0" "0.927" "0.901" "0.949" "0.878" "0.882" "1.019" "1.097" "1.173" "0.600" "500.3" "463.9" "451.0" "474.8" "439.3" "441.1" "509.6" "549.1" "586.7" "300.1" "" "" "" "" "" "" "" "" "" "" "443.7" "384.2" "393.5" "355.1" "366.4" "405.2" "430.7" "453.9" "538.1" "300.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "High" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.000" "False" "47.369" "46" "5" "35" "5" "115" "12.5" "7.88" "107.54" "5" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "6" "0" "0.983" "0.929" "1.022" "0.897" "0.899" "0.917" "0.913" "0.963" "0.467" "2013.0" "1978.2" "1870.5" "2056.9" "1805.7" "1810.4" "1845.4" "1837.7" "1938.7" "940.7" "" "" "" "" "" "" "" "" "" "" "1785.1" "1638.7" "1632.1" "1538.3" "1505.7" "1663.0" "1559.7" "1519.0" "1778.0" "940.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "47.326" "21" "4" "23" "4" "195" "19.5" "4.67" "87.98" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "0.924" "0.932" "0.914" "0.918" "0.915" "0.854" "0.897" "0.888" "0.403" "4915.0" "4543.0" "4583.0" "4493.8" "4510.2" "4498.6" "4196.3" "4410.3" "4366.5" "1982.7" "" "" "" "" "" "" "" "" "" "" "4358.5" "3763.2" "3998.9" "3360.8" "3760.9" "4132.4" "3546.6" "3645.4" "4004.7" "1982.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739657141075103728" "False" "High" "IsMasterProtein" "Q9NRN9" "rRNA N6-adenosine-methyltransferase METTL5 OS=Homo sapiens OX=9606 GN=METTL5 PE=1 SV=1" "0.000" "False" "47.325" "34" "6" "13" "6" "209" "23.7" "6.68" "48.99" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29081" "ENSG00000138382" "METTL5" "D3DPC9; hsa:29081; Q9NRN9; Q9NVX1" "" "" "0" "0" "1.045" "1.059" "1.064" "1.052" "1.081" "1.052" "1.078" "0.994" "0.528" "1287.1" "1345.5" "1362.8" "1369.0" "1354.1" "1391.8" "1354.2" "1387.2" "1280.0" "680.2" "" "" "" "" "" "" "" "" "" "" "1141.4" "1114.5" "1189.1" "1023.8" "1129.1" "1278.5" "1144.5" "1146.6" "1174.0" "680.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117029845093264208" "False" "High" "IsMasterProtein" "O75600" "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens OX=9606 GN=GCAT PE=1 SV=1" "0.000" "False" "47.281" "16" "5" "6" "5" "419" "45.3" "8.05" "29.54" "5" "other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00155" "23464" "ENSG00000100116" "GCAT" "E2QC23; hsa:23464; O75600; Q6ZWF1; Q96CA9" "Threonine catabolism" "" "1" "0" "1.072" "1.029" "1.034" "1.098" "1.060" "1.045" "1.100" "0.929" "0.558" "268.2" "287.4" "276.0" "277.2" "294.6" "284.3" "280.2" "294.9" "249.0" "149.7" "" "" "" "" "" "" "" "" "" "" "237.8" "238.1" "240.8" "207.3" "245.6" "261.1" "236.8" "243.8" "228.4" "149.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "47.274" "32" "10" "22" "10" "314" "34.3" "8.85" "68.62" "10" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "12" "0" "0.963" "0.954" "0.912" "0.919" "0.884" "0.917" "0.969" "0.942" "0.456" "3402.3" "3276.3" "3245.2" "3102.0" "3126.6" "3009.3" "3120.5" "3298.2" "3205.7" "1552.7" "" "" "" "" "" "" "" "" "" "" "3017.1" "2714.0" "2831.6" "2319.9" "2607.2" "2764.4" "2637.3" "2726.2" "2940.0" "1552.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "47.261" "24" "11" "12" "11" "522" "58.4" "7.42" "42.23" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.029" "1.058" "1.037" "1.070" "1.105" "1.096" "1.050" "1.057" "1.882" "907.0" "933.5" "959.3" "940.6" "970.1" "1002.4" "994.5" "952.4" "958.3" "1707.1" "" "" "" "" "" "" "" "" "" "" "804.3" "773.2" "837.1" "703.5" "808.9" "920.8" "840.5" "787.2" "878.9" "1707.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "High" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.000" "False" "47.253" "35" "3" "11" "3" "123" "13.8" "6.52" "48.77" "3" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "1.029" "1.059" "1.116" "1.106" "1.098" "1.117" "1.078" "0.979" "0.584" "928.8" "955.6" "984.0" "1037.0" "1027.5" "1019.4" "1037.5" "1001.1" "909.6" "542.7" "" "" "" "" "" "" "" "" "" "" "823.6" "791.6" "858.6" "775.5" "856.8" "936.4" "876.9" "827.5" "834.2" "542.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002757993896463050" "False" "High" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "0.000" "False" "47.239" "9" "10" "13" "10" "1124" "124.1" "8.07" "38.78" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "Retinoblastoma gene in cancer; Nephrotic syndrome" "5" "0" "1.075" "0.951" "0.941" "0.982" "0.895" "0.951" "0.858" "0.978" "3.148" "557.6" "599.5" "530.2" "524.9" "547.5" "499.1" "530.2" "478.4" "545.7" "1755.4" "" "" "" "" "" "" "" "" "" "" "494.5" "496.6" "462.6" "392.5" "456.5" "458.5" "448.1" "395.4" "500.4" "1755.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "47.211" "8" "8" "11" "8" "1153" "130.1" "8.48" "45.83" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "0.955" "0.940" "0.927" "0.948" "0.929" "0.997" "0.877" "1.001" "2.489" "742.9" "709.4" "698.6" "688.5" "704.6" "690.4" "740.4" "651.4" "743.9" "1849.6" "" "" "" "" "" "" "" "" "" "" "658.8" "587.6" "609.5" "514.9" "587.5" "634.2" "625.8" "538.5" "682.3" "1849.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "47.200" "44" "6" "19" "6" "131" "13.8" "9.77" "63.44" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "0.939" "0.927" "0.963" "0.893" "0.885" "0.866" "0.978" "0.934" "0.499" "2644.3" "2481.8" "2450.0" "2545.6" "2360.4" "2340.4" "2289.2" "2585.7" "2469.7" "1318.5" "" "" "" "" "" "" "" "" "" "" "2344.9" "2055.8" "2137.7" "1903.8" "1968.2" "2150.0" "1934.8" "2137.3" "2265.1" "1318.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "47.179" "15" "8" "13" "7" "593" "65.2" "9.70" "37.43" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "" "6" "1" "1.131" "0.889" "1.169" "0.912" "0.804" "0.942" "0.715" "0.956" "4.219" "686.4" "776.6" "610.0" "802.2" "626.3" "552.0" "646.8" "490.6" "655.9" "2896.1" "" "" "" "" "" "" "" "" "" "" "608.7" "643.3" "532.2" "599.9" "522.3" "507.1" "546.7" "405.6" "601.5" "2896.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "47.179" "41" "10" "14" "10" "299" "33.4" "5.25" "45.11" "10" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "1.041" "1.033" "1.056" "1.057" "0.941" "1.050" "0.843" "1.001" "3.726" "1602.4" "1668.8" "1655.2" "1691.4" "1694.3" "1507.4" "1682.8" "1351.6" "1603.8" "5970.3" "" "" "" "" "" "" "" "" "" "" "1421.0" "1382.4" "1444.2" "1264.9" "1412.8" "1384.7" "1422.2" "1117.2" "1470.9" "5970.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "47.172" "24" "3" "38" "3" "86" "9.7" "4.67" "143.02" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.087" "1.007" "1.094" "1.052" "1.027" "1.104" "1.107" "0.993" "0.579" "3501.0" "3804.9" "3525.9" "3829.1" "3684.1" "3596.2" "3865.9" "3875.3" "3476.0" "2025.5" "" "" "" "" "" "" "" "" "" "" "3104.6" "3151.8" "3076.6" "2863.7" "3072.0" "3303.5" "3267.3" "3203.2" "3187.9" "2025.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "47.140" "11" "9" "12" "9" "932" "97.3" "8.63" "45.32" "9" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "1.122" "1.020" "1.126" "1.129" "1.037" "1.082" "0.841" "0.967" "4.301" "1052.9" "1181.7" "1073.5" "1185.2" "1188.8" "1091.5" "1139.6" "885.9" "1018.2" "4528.5" "" "" "" "" "" "" "" "" "" "" "933.7" "978.9" "936.7" "886.3" "991.3" "1002.7" "963.1" "732.3" "933.8" "4528.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463196673493200714" "False" "High" "IsMasterProtein" "P01116" "GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1" "0.000" "False" "47.136" "30" "4" "8" "1" "189" "21.6" "6.77" "34.46" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00071" "3845" "ENSG00000133703" "KRAS" "A8K8Z5; B0LPF9; hsa:3845; P01116; P01118; Q96D10" "Signaling by CSF3 (G-CSF); Signaling by CSF1 (M-CSF) in myeloid cells; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants; RUNX3 regulates p14-ARF" "IL-5 signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; MAPK pathway in congenital thyroid cancer; Regulation of actin cytoskeleton; Alzheimer's disease; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "60" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "47.131" "30" "13" "18" "13" "432" "51.4" "9.79" "56.81" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "mRNA Splicing - Major Pathway" "" "1" "0" "0.979" "0.885" "1.021" "0.935" "0.918" "1.055" "1.011" "1.172" "1.486" "1442.0" "1411.9" "1275.8" "1472.0" "1347.9" "1323.1" "1521.5" "1457.9" "1689.4" "2143.0" "" "" "" "" "" "" "" "" "" "" "1278.7" "1169.5" "1113.2" "1100.9" "1123.9" "1215.4" "1285.9" "1205.0" "1549.4" "2143.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4704340040215325088" "False" "High" "IsMasterProtein" "Q9GZN8" "Adipose-secreted signaling protein OS=Homo sapiens OX=9606 GN=ADISSP PE=1 SV=3" "0.000" "False" "47.061" "53" "6" "8" "6" "174" "19.3" "6.84" "34.78" "6" "other metabolic processes;other biological processes" "non-structural extracellular" "other molecular function" "Pf15006" "54976" "ENSG00000101220" "ADISSP" "A8K4J0; D3DVX8; hsa:54976; Q5JX81; Q9GZN8; Q9NWX3" "" "" "0" "0" "0.976" "1.073" "1.153" "1.154" "1.078" "1.036" "1.202" "1.116" "0.676" "553.3" "540.1" "593.8" "638.0" "638.4" "596.3" "573.5" "665.1" "617.4" "374.3" "" "" "" "" "" "" "" "" "" "" "490.7" "447.4" "518.2" "477.1" "532.4" "547.8" "484.7" "549.8" "566.2" "374.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5891546535660205639" "False" "High" "IsMasterProtein" "Q6P1X6" "UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2" "0.000" "False" "47.018" "33" "6" "11" "6" "216" "23.9" "9.14" "43.36" "6" "" "" "" "Pf14956" "414919" "ENSG00000213563" "C8orf82" "hsa:414919; Q6GMR2; Q6P1X6; Q6P2Q7" "" "" "0" "0" "1.026" "1.029" "1.063" "1.068" "1.056" "1.003" "1.055" "0.966" "0.527" "1039.7" "1067.1" "1069.3" "1104.9" "1110.5" "1097.6" "1043.1" "1097.1" "1004.7" "548.2" "" "" "" "" "" "" "" "" "" "" "922.0" "883.9" "933.0" "826.3" "926.0" "1008.3" "881.6" "906.9" "921.5" "548.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "47.005" "32" "9" "16" "9" "308" "33.8" "8.12" "55.85" "9" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "0.955" "0.983" "0.954" "0.961" "1.013" "1.023" "1.087" "1.000" "0.610" "1535.0" "1465.8" "1508.7" "1464.6" "1475.4" "1554.4" "1570.5" "1668.1" "1535.6" "936.6" "" "" "" "" "" "" "" "" "" "" "1361.2" "1214.2" "1316.4" "1095.4" "1230.3" "1427.9" "1327.3" "1378.8" "1408.3" "936.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4995035234308884546" "False" "High" "IsMasterProtein" "Q9Y6B6" "Small COPII coat GTPase SAR1B OS=Homo sapiens OX=9606 GN=SAR1B PE=1 SV=1" "0.000" "False" "46.929" "25" "5" "19" "2" "198" "22.4" "6.11" "57.91" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00025" "51128" "ENSG00000152700" "SAR1B" "D3DQA4; hsa:51128; Q567T4; Q9Y6B6" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Chylomicron assembly" "Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism; Enterocyte cholesterol metabolism" "10" "0" "1.039" "1.211" "0.898" "1.148" "1.041" "0.990" "0.988" "1.135" "0.633" "920.9" "957.1" "1114.9" "827.3" "1057.0" "958.3" "911.3" "909.7" "1045.1" "583.3" "" "" "" "" "" "" "" "" "" "" "816.6" "792.8" "972.8" "618.7" "881.4" "880.3" "770.2" "751.9" "958.5" "583.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "46.873" "11" "9" "11" "9" "956" "106.8" "5.94" "41.68" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "" "Nanoparticle triggered autophagic cell death" "1" "0" "0.951" "0.970" "0.977" "0.917" "0.963" "0.912" "0.744" "0.998" "3.662" "997.0" "947.9" "967.4" "973.8" "914.1" "960.2" "909.6" "742.2" "995.0" "3650.8" "" "" "" "" "" "" "" "" "" "" "884.1" "785.2" "844.1" "728.3" "762.2" "882.1" "768.8" "613.5" "912.6" "3650.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4173136633731686100" "False" "High" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.000" "False" "46.823" "12" "11" "12" "11" "882" "97.5" "6.21" "39.49" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "13" "0" "1.032" "0.952" "1.011" "0.942" "1.018" "0.930" "0.835" "0.971" "2.028" "853.0" "880.1" "811.8" "862.0" "803.3" "868.1" "793.7" "712.4" "828.0" "1730.2" "" "" "" "" "" "" "" "" "" "" "756.4" "729.0" "708.4" "644.7" "669.8" "797.4" "670.8" "588.9" "759.4" "1730.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.000" "False" "46.774" "12" "9" "10" "9" "1059" "112.1" "7.30" "35.59" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "1.013" "0.925" "0.969" "0.896" "0.953" "1.072" "0.797" "1.043" "5.003" "598.9" "606.4" "553.7" "580.3" "536.7" "570.8" "641.9" "477.5" "624.9" "2996.3" "" "" "" "" "" "" "" "" "" "" "531.1" "502.3" "483.1" "434.0" "447.5" "524.3" "542.5" "394.7" "573.1" "2996.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4208729749156870383" "False" "High" "IsMasterProtein" "O60678" "Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4" "0.000" "False" "46.741" "18" "8" "11" "8" "531" "59.9" "5.35" "42.84" "8" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf06325, Pf21137, Pf21336" "10196" "ENSG00000185238" "PRMT3" "A0A0A0MSN7; B4DUC7; hsa:10196; O60678" "RMTs methylate histone arginines; Protein methylation" "Nitric oxide metabolism in cystic fibrosis" "3" "0" "1.008" "0.973" "0.952" "0.832" "0.874" "0.797" "0.705" "0.848" "2.654" "1133.0" "1141.6" "1102.2" "1078.5" "943.0" "990.7" "903.3" "798.6" "960.2" "3007.0" "" "" "" "" "" "" "" "" "" "" "1004.7" "945.7" "961.7" "806.6" "786.3" "910.1" "763.4" "660.1" "880.7" "3007.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9041443353459398324" "False" "High" "IsMasterProtein" "Q8N9N7" "Leucine-rich repeat-containing protein 57 OS=Homo sapiens OX=9606 GN=LRRC57 PE=1 SV=1" "0.000" "False" "46.740" "33" "8" "13" "8" "239" "26.7" "8.43" "48.97" "8" "" "other membranes" "" "Pf13855" "255252" "ENSG00000180979" "LRRC57" "hsa:255252; Q7Z2Z6; Q8N1T6; Q8N9N7" "" "" "0" "0" "1.025" "1.037" "0.995" "1.027" "1.020" "1.089" "1.086" "1.072" "0.706" "1403.4" "1438.8" "1455.8" "1396.8" "1441.3" "1430.8" "1527.8" "1524.1" "1504.1" "990.5" "" "" "" "" "" "" "" "" "" "" "1244.5" "1191.9" "1270.2" "1044.6" "1201.8" "1314.3" "1291.2" "1259.8" "1379.5" "990.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4577230366185343110" "False" "High" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "0.000" "False" "46.724" "24" "9" "10" "9" "510" "56.5" "7.18" "37.15" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "0.988" "0.894" "1.052" "0.956" "0.986" "0.998" "0.849" "0.858" "0.787" "948.0" "936.3" "847.3" "997.1" "905.9" "934.3" "945.7" "805.1" "813.3" "745.7" "" "" "" "" "" "" "" "" "" "" "840.7" "775.6" "739.3" "745.7" "755.4" "858.2" "799.2" "665.4" "745.9" "745.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008676394331225875" "False" "High" "IsMasterProtein" "Q9ULV3" "Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2" "0.000" "False" "46.660" "12" "8" "8" "8" "898" "100.0" "6.11" "33.57" "8" "other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "25792" "ENSG00000148337" "CIZ1" "A8K9J8; B4E131; B7ZAS8; hsa:25792; Q5SYW3; Q5SYW5; Q8WU72; Q9H868; Q9NYM8; Q9UHK4; Q9ULV3; Q9Y3F9; Q9Y3G0" "" "" "0" "0" "0.962" "0.885" "0.879" "0.813" "0.844" "0.770" "0.821" "0.824" "0.902" "815.9" "784.6" "722.3" "717.3" "663.1" "688.6" "628.0" "669.5" "672.7" "735.6" "" "" "" "" "" "" "" "" "" "" "723.6" "649.9" "630.2" "536.5" "553.0" "632.5" "530.8" "553.4" "616.9" "735.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "46.646" "19" "11" "17" "8" "472" "51.5" "5.16" "52.31" "11" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Formation of the cornified envelope; Type I hemidesmosome assembly" "Corticotropin-releasing hormone signaling pathway" "4" "0" "0.432" "3.821" "0.874" "0.349" "0.807" "1.200" "0.461" "0.435" "0.695" "344.5" "148.7" "1316.3" "301.1" "120.1" "277.9" "413.5" "158.8" "149.7" "239.4" "" "" "" "" "" "" "" "" "" "" "305.5" "123.1" "1148.5" "225.2" "100.2" "255.3" "349.5" "131.3" "137.3" "239.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "46.636" "38" "8" "17" "8" "229" "26.6" "5.71" "58.21" "8" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "mRNA Splicing - Major Pathway" "" "1" "0" "0.904" "0.877" "0.861" "0.812" "0.794" "0.728" "0.884" "0.950" "0.395" "2335.4" "2112.2" "2047.2" "2011.3" "1896.8" "1854.3" "1700.8" "2065.3" "2219.3" "922.3" "" "" "" "" "" "" "" "" "" "" "2071.0" "1749.7" "1786.3" "1504.2" "1581.7" "1703.4" "1437.5" "1707.1" "2035.4" "922.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "46.620" "7" "12" "13" "12" "1668" "196.5" "9.42" "46.00" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "0.922" "0.928" "0.948" "0.870" "0.919" "0.881" "0.819" "0.872" "1.193" "961.7" "886.4" "892.1" "911.9" "836.5" "884.1" "847.5" "787.6" "838.9" "1147.7" "" "" "" "" "" "" "" "" "" "" "852.8" "734.3" "778.4" "682.0" "697.6" "812.1" "716.3" "651.0" "769.4" "1147.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "46.582" "15" "10" "12" "10" "691" "79.4" "5.67" "42.14" "10" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "TBC/RABGAPs" "" "1" "0" "1.021" "1.121" "0.958" "1.038" "1.117" "1.022" "0.918" "1.179" "3.799" "1473.8" "1504.4" "1652.0" "1411.7" "1530.4" "1646.3" "1506.1" "1352.8" "1737.2" "5598.7" "" "" "" "" "" "" "" "" "" "" "1306.9" "1246.1" "1441.5" "1055.7" "1276.2" "1512.4" "1272.9" "1118.2" "1593.2" "5598.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7507804791058133428" "False" "High" "IsMasterProtein" "Q9NX74" "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens OX=9606 GN=DUS2 PE=1 SV=1" "0.000" "False" "46.529" "17" "9" "11" "9" "493" "55.0" "7.11" "40.00" "9" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf01207" "54920" "ENSG00000167264" "DUS2" "A8K3G3; hsa:54920; Q4H4D9; Q9NX74" "PKR-mediated signaling; tRNA modification in the nucleus and cytosol" "" "2" "0" "1.060" "1.054" "1.013" "1.050" "1.088" "0.838" "0.864" "0.921" "1.144" "1071.8" "1136.2" "1129.7" "1086.0" "1125.1" "1166.1" "897.9" "926.2" "987.1" "1226.5" "" "" "" "" "" "" "" "" "" "" "950.4" "941.2" "985.7" "812.2" "938.2" "1071.2" "758.9" "765.6" "905.3" "1226.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "46.476" "43" "8" "17" "8" "203" "23.2" "7.88" "56.81" "8" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "4" "0" "1.019" "0.971" "1.135" "1.147" "1.157" "1.283" "1.334" "1.309" "0.979" "1111.6" "1132.7" "1079.9" "1262.2" "1275.6" "1286.5" "1426.2" "1483.1" "1454.9" "1088.1" "" "" "" "" "" "" "" "" "" "" "985.8" "938.3" "942.3" "944.0" "1063.7" "1181.7" "1205.4" "1225.9" "1334.4" "1088.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-815619529761870657" "False" "High" "IsMasterProtein" "Q6P996" "Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2" "0.000" "False" "46.462" "17" "11" "13" "11" "788" "86.7" "5.38" "44.32" "11" "other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00282" "23042" "ENSG00000179889; ENSG00000275498" "PDXDC1" "B4DR55; B4DSL3; E7EMH5; E7EPL4; H3BNZ1; hsa:23042; O00236; Q4F6X7; Q6P996; Q6PID7; Q86YF1; Q8N4Q9; Q8TBS5" "" "" "0" "0" "0.980" "1.180" "1.278" "1.179" "1.312" "1.192" "1.209" "1.175" "2.660" "1630.8" "1597.8" "1924.3" "2083.7" "1922.1" "2138.8" "1944.6" "1972.0" "1916.6" "4337.0" "" "" "" "" "" "" "" "" "" "" "1446.1" "1323.5" "1679.1" "1558.3" "1602.8" "1964.8" "1643.5" "1630.0" "1757.7" "4337.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "46.394" "75" "4" "15" "4" "68" "7.4" "7.24" "66.97" "4" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "Copper homeostasis" "3" "0" "0.970" "0.961" "1.092" "1.046" "0.934" "0.995" "1.069" "0.997" "0.525" "1589.8" "1542.9" "1527.8" "1736.4" "1662.1" "1485.3" "1581.7" "1699.5" "1585.3" "834.1" "" "" "" "" "" "" "" "" "" "" "1409.8" "1278.0" "1333.1" "1298.6" "1386.0" "1364.4" "1336.8" "1404.7" "1453.9" "834.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366730786778732406" "False" "High" "IsMasterProtein" "Q9UKB3" "DnaJ homolog subfamily C member 12 OS=Homo sapiens OX=9606 GN=DNAJC12 PE=1 SV=1" "0.000" "False" "46.365" "40" "9" "18" "9" "198" "23.4" "5.71" "56.64" "9" "" "other cell component" "" "Pf00226" "56521" "ENSG00000108176" "DNAJC12" "hsa:56521; Q5JVQ1; Q9UKB2; Q9UKB3" "" "" "0" "0" "0.953" "0.940" "0.922" "0.881" "0.856" "0.821" "0.867" "0.850" "0.601" "1530.1" "1457.8" "1438.5" "1411.5" "1347.5" "1310.4" "1256.3" "1326.5" "1300.7" "919.1" "" "" "" "" "" "" "" "" "" "" "1356.8" "1207.6" "1255.2" "1055.6" "1123.7" "1203.8" "1061.8" "1096.5" "1193.0" "919.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8122184501551353547" "False" "High" "IsMasterProtein" "Q9NZI8" "Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2" "0.000" "False" "46.329" "22" "12" "16" "10" "577" "63.4" "9.20" "54.03" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10642" "ENSG00000159217" "IGF2BP1" "C9JT33; hsa:10642; Q9NZI8" "MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "Brain-derived neurotrophic factor (BDNF) signaling pathway; eIF5A regulation in response to inhibition of the nuclear export system" "4" "1" "1.000" "0.922" "1.078" "0.982" "0.909" "0.982" "0.414" "0.968" "9.882" "1022.5" "1022.4" "942.9" "1101.8" "1003.9" "929.0" "1003.6" "423.2" "989.9" "10103.6" "" "" "" "" "" "" "" "" "" "" "906.7" "846.9" "822.7" "824.0" "837.1" "853.4" "848.2" "349.8" "907.8" "10103.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "High" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.000" "False" "46.251" "32" "8" "12" "8" "274" "29.0" "5.58" "59.35" "8" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Detoxification of Reactive Oxygen Species" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "3" "0" "0.893" "0.903" "0.956" "0.846" "0.775" "0.899" "0.878" "0.975" "0.877" "932.5" "832.7" "842.4" "891.8" "788.8" "722.9" "838.3" "818.6" "909.4" "817.8" "" "" "" "" "" "" "" "" "" "" "827.0" "689.7" "735.0" "666.9" "657.7" "664.0" "708.5" "676.6" "834.1" "817.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "46.212" "24" "6" "10" "6" "346" "39.2" "5.50" "39.41" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "15" "0" "1.016" "0.972" "1.008" "0.986" "0.999" "1.248" "1.100" "1.182" "3.734" "585.1" "594.6" "568.6" "589.8" "577.1" "584.4" "730.2" "643.6" "691.8" "2184.4" "" "" "" "" "" "" "" "" "" "" "518.8" "492.5" "496.1" "441.1" "481.2" "536.8" "617.2" "532.0" "634.4" "2184.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.000" "False" "46.174" "29" "6" "9" "6" "276" "31.6" "5.59" "37.87" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "0.987" "1.063" "1.057" "1.042" "1.035" "1.055" "1.095" "1.086" "0.636" "1188.5" "1172.6" "1262.9" "1256.4" "1238.8" "1229.6" "1253.6" "1301.5" "1291.1" "756.3" "" "" "" "" "" "" "" "" "" "" "1053.9" "971.3" "1101.9" "939.6" "1033.0" "1129.5" "1059.5" "1075.8" "1184.1" "756.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7796576881168078978" "False" "High" "IsMasterProtein" "Q9P2R6" "Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens OX=9606 GN=RERE PE=1 SV=2" "0.000" "False" "46.130" "6" "10" "12" "9" "1566" "172.3" "7.69" "37.08" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf03154" "473" "ENSG00000142599" "RERE" "hsa:473; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9P2R6; Q9Y2W4" "" "" "0" "0" "1.031" "1.082" "0.994" "1.083" "1.124" "0.997" "0.974" "1.026" "1.516" "682.1" "702.9" "738.0" "678.1" "739.0" "766.6" "679.9" "664.1" "699.6" "1033.8" "" "" "" "" "" "" "" "" "" "" "604.9" "582.3" "643.9" "507.2" "616.2" "704.2" "574.6" "548.9" "641.6" "1033.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "High" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.000" "False" "46.111" "18" "10" "17" "10" "489" "54.2" "5.88" "58.21" "10" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "1.026" "0.987" "1.062" "0.988" "0.992" "1.072" "0.977" "0.980" "1.422" "1670.0" "1713.2" "1648.8" "1774.1" "1649.3" "1657.0" "1790.0" "1630.9" "1635.7" "2374.7" "" "" "" "" "" "" "" "" "" "" "1480.9" "1419.1" "1438.7" "1326.8" "1375.3" "1522.1" "1512.8" "1348.0" "1500.2" "2374.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "46.083" "35" "4" "8" "4" "178" "19.3" "4.63" "33.00" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "1.099" "1.019" "1.230" "1.102" "0.902" "1.210" "1.025" "0.925" "0.596" "753.5" "828.1" "767.8" "926.7" "830.0" "679.5" "911.9" "772.2" "697.3" "449.0" "" "" "" "" "" "" "" "" "" "" "668.2" "685.9" "669.9" "693.0" "692.1" "624.2" "770.7" "638.3" "639.5" "449.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2737319948807008641" "False" "High" "IsMasterProtein" "Q9H8G2" "Caspase activity and apoptosis inhibitor 1 OS=Homo sapiens OX=9606 GN=CAAP1 PE=1 SV=2" "0.000" "False" "46.061" "21" "4" "7" "4" "361" "38.3" "4.72" "34.12" "4" "other biological processes" "" "" "Pf15335" "79886" "ENSG00000120159" "CAAP1" "B4DWT4; D3DRK4; hsa:79886; Q5VY32; Q6IPE6; Q96C59; Q9H8G2" "" "Acute viral myocarditis" "1" "0" "0.985" "0.943" "1.026" "0.969" "1.004" "0.965" "0.962" "0.979" "0.640" "502.3" "494.7" "473.4" "515.3" "486.5" "504.3" "484.5" "483.3" "491.7" "321.4" "" "" "" "" "" "" "" "" "" "" "445.4" "409.8" "413.1" "385.4" "405.6" "463.2" "409.5" "399.5" "451.0" "321.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "46.060" "27" "7" "9" "7" "393" "44.3" "5.07" "34.02" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "Macroautophagy" "2q37 copy number variation syndrome" "2" "0" "0.975" "1.016" "1.068" "1.060" "0.886" "1.073" "0.725" "0.989" "7.689" "143.3" "139.8" "145.7" "153.2" "152.0" "126.9" "153.7" "104.0" "141.8" "1102.1" "" "" "" "" "" "" "" "" "" "" "127.1" "115.8" "127.1" "114.5" "126.8" "116.6" "129.9" "86.0" "130.1" "1102.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "46.051" "31" "8" "11" "8" "341" "37.5" "7.43" "43.92" "8" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "1.059" "1.033" "1.076" "1.062" "1.040" "1.001" "1.070" "0.913" "0.958" "1177.6" "1247.1" "1217.0" "1266.7" "1250.5" "1225.0" "1178.3" "1259.7" "1074.6" "1128.5" "" "" "" "" "" "" "" "" "" "" "1044.3" "1033.0" "1061.9" "947.3" "1042.8" "1125.3" "995.8" "1041.2" "985.6" "1128.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "High" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.000" "False" "45.905" "17" "13" "14" "13" "822" "91.9" "6.65" "50.67" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "1.000" "1.002" "0.948" "0.886" "0.925" "0.861" "0.862" "0.887" "1.841" "1339.8" "1340.0" "1343.0" "1270.7" "1187.6" "1239.5" "1153.4" "1155.5" "1188.0" "2466.7" "" "" "" "" "" "" "" "" "" "" "1188.1" "1110.0" "1171.8" "950.3" "990.3" "1138.6" "974.8" "955.1" "1089.5" "2466.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "45.904" "15" "10" "11" "9" "725" "81.3" "7.83" "37.28" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "Microtubule cytoskeleton regulation" "10" "0" "1.177" "1.073" "1.280" "1.136" "1.131" "1.139" "0.758" "1.076" "4.654" "356.1" "419.0" "382.2" "456.0" "404.7" "402.8" "405.6" "270.0" "383.3" "1657.3" "" "" "" "" "" "" "" "" "" "" "315.8" "347.1" "333.5" "341.0" "337.5" "370.0" "342.8" "223.2" "351.5" "1657.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.000" "False" "45.878" "8" "9" "9" "8" "1235" "142.6" "5.15" "35.17" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "TAR syndrome" "4" "0" "0.982" "0.934" "1.002" "0.886" "0.896" "0.943" "0.712" "0.920" "4.390" "449.5" "441.6" "419.9" "450.2" "398.1" "402.9" "423.8" "320.1" "413.4" "1973.0" "" "" "" "" "" "" "" "" "" "" "398.6" "365.8" "366.4" "336.7" "332.0" "370.1" "358.2" "264.6" "379.1" "1973.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "45.825" "45" "4" "17" "4" "95" "10.5" "8.18" "44.94" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "Mitochondrial protein import" "" "1" "0" "1.065" "1.005" "1.020" "1.018" "0.956" "1.043" "1.025" "0.954" "0.407" "1585.3" "1687.6" "1593.1" "1617.7" "1614.3" "1515.2" "1653.6" "1625.5" "1512.6" "645.9" "" "" "" "" "" "" "" "" "" "" "1405.8" "1397.9" "1390.0" "1209.8" "1346.1" "1391.9" "1397.5" "1343.6" "1387.2" "645.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "938742805709954505" "False" "High" "IsMasterProtein" "Q9H3F6" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1" "0.000" "False" "45.817" "24" "8" "11" "8" "313" "35.4" "6.34" "32.34" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02214" "83892" "ENSG00000110906" "KCTD10" "hsa:83892; Q53HN2; Q59FV1; Q6PL47; Q96SU0; Q9H3F6" "" "" "0" "0" "1.137" "1.092" "1.037" "1.175" "1.122" "1.091" "1.100" "1.023" "0.628" "434.6" "493.9" "474.6" "450.9" "510.5" "487.8" "474.1" "478.1" "444.6" "273.1" "" "" "" "" "" "" "" "" "" "" "385.4" "409.1" "414.1" "337.2" "425.7" "448.1" "400.7" "395.2" "407.8" "273.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "High" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.000" "False" "45.707" "49" "5" "9" "5" "130" "15.0" "5.02" "38.07" "5" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "Apoptosis modulation and signaling" "3" "0" "1.304" "1.048" "1.113" "1.098" "1.097" "1.096" "0.897" "1.081" "2.552" "605.5" "789.5" "634.4" "673.8" "665.0" "664.5" "663.9" "543.1" "654.7" "1545.2" "" "" "" "" "" "" "" "" "" "" "536.9" "654.0" "553.5" "503.9" "554.5" "610.4" "561.1" "448.9" "600.4" "1545.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1498458301552967093" "False" "High" "IsMasterProtein" "P13716" "Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1" "0.000" "False" "45.703" "30" "9" "10" "9" "330" "36.3" "6.79" "38.37" "9" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00490" "210" "ENSG00000148218" "ALAD" "A8K375; B2R6F2; hsa:210; P13716; Q16870; Q16871; Q9BVQ9" "Neutrophil degranulation; Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "1.186" "1.026" "1.145" "1.049" "1.095" "1.131" "1.020" "1.089" "0.599" "713.5" "846.6" "732.3" "817.3" "748.4" "781.6" "807.0" "727.8" "777.1" "427.7" "" "" "" "" "" "" "" "" "" "" "632.7" "701.2" "639.0" "611.2" "624.0" "718.0" "682.1" "601.6" "712.7" "427.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021829867861972309" "False" "High" "IsMasterProtein" "Q14671" "Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3" "0.000" "False" "45.667" "8" "9" "10" "5" "1186" "126.4" "6.84" "35.18" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "9698" "ENSG00000134644" "PUM1" "A8K6W4; B4DG92; D3DPN3; E9PCJ0; hsa:9698; Q14671; Q53HH5; Q5VXY7; Q9HAN1" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.048" "0.955" "0.999" "0.974" "0.877" "0.990" "0.823" "0.989" "1.858" "298.6" "313.0" "285.1" "298.3" "290.8" "261.9" "295.7" "245.8" "295.4" "554.8" "" "" "" "" "" "" "" "" "" "" "264.8" "259.2" "248.8" "223.1" "242.5" "240.6" "249.9" "203.2" "270.9" "554.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.000" "False" "45.653" "23" "9" "13" "9" "442" "50.5" "5.63" "48.63" "9" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "Potential therapeutics for SARS" "" "1" "0" "1.071" "0.990" "1.159" "1.088" "1.084" "1.106" "1.064" "0.969" "0.670" "1369.7" "1467.1" "1355.8" "1587.9" "1489.7" "1484.6" "1514.9" "1457.7" "1327.9" "917.2" "" "" "" "" "" "" "" "" "" "" "1214.6" "1215.3" "1183.0" "1187.6" "1242.2" "1363.8" "1280.3" "1204.9" "1217.8" "917.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "45.591" "27" "7" "18" "7" "306" "32.7" "5.06" "70.50" "7" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing" "mRNA processing" "7" "0" "0.976" "0.986" "0.899" "0.917" "0.901" "0.896" "0.902" "0.869" "1.241" "2048.9" "2000.1" "2019.6" "1841.9" "1877.9" "1846.4" "1835.0" "1847.8" "1780.0" "2542.9" "" "" "" "" "" "" "" "" "" "" "1816.9" "1656.8" "1762.2" "1377.5" "1565.9" "1696.2" "1550.8" "1527.3" "1632.5" "2542.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "45.581" "20" "8" "10" "8" "454" "51.3" "4.97" "41.21" "8" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "7" "0" "0.987" "0.988" "0.977" "1.006" "1.048" "0.978" "0.892" "1.018" "3.401" "981.1" "968.4" "968.9" "958.1" "986.8" "1027.8" "959.4" "874.8" "999.0" "3337.1" "" "" "" "" "" "" "" "" "" "" "870.1" "802.2" "845.4" "716.5" "822.8" "944.1" "810.9" "723.1" "916.2" "3337.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.000" "False" "45.544" "29" "3" "25" "3" "108" "11.9" "8.16" "96.87" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "14" "0" "1.006" "0.981" "1.055" "1.019" "0.998" "0.986" "0.997" "0.922" "0.731" "2556.3" "2571.4" "2506.8" "2696.4" "2604.8" "2551.2" "2520.5" "2548.6" "2356.6" "1869.1" "" "" "" "" "" "" "" "" "" "" "2266.8" "2130.0" "2187.3" "2016.5" "2172.0" "2343.5" "2130.2" "2106.6" "2161.3" "1869.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "614531152509290275" "False" "High" "IsMasterProtein" "Q9BRD0" "BUD13 homolog OS=Homo sapiens OX=9606 GN=BUD13 PE=1 SV=1" "0.000" "False" "45.539" "18" "10" "16" "10" "619" "70.5" "9.86" "41.08" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf09736" "84811" "ENSG00000137656" "BUD13" "A8K0S0; hsa:84811; Q96LS7; Q9BRD0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.024" "1.053" "1.083" "1.069" "0.939" "0.941" "1.021" "0.997" "0.781" "487.4" "499.0" "513.5" "527.8" "521.3" "457.5" "458.9" "497.7" "486.1" "380.4" "" "" "" "" "" "" "" "" "" "" "432.2" "413.4" "448.0" "394.8" "434.7" "420.2" "387.8" "411.4" "445.8" "380.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "45.504" "24" "6" "11" "6" "338" "37.9" "7.42" "39.07" "6" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "Neutrophil degranulation" "" "1" "0" "0.963" "0.889" "0.971" "0.949" "0.967" "0.992" "0.934" "0.987" "0.787" "608.3" "585.5" "540.6" "590.4" "577.3" "588.3" "603.5" "568.1" "600.3" "478.7" "" "" "" "" "" "" "" "" "" "" "539.4" "485.0" "471.7" "441.5" "481.4" "540.4" "510.1" "469.6" "550.6" "478.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "45.500" "17" "9" "22" "9" "479" "53.5" "4.81" "67.94" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors" "4" "0" "1.014" "0.955" "1.008" "0.965" "0.960" "0.936" "0.991" "1.009" "0.563" "1704.2" "1727.3" "1628.2" "1717.7" "1644.4" "1636.8" "1595.5" "1689.0" "1719.8" "958.7" "" "" "" "" "" "" "" "" "" "" "1511.3" "1430.8" "1420.7" "1284.6" "1371.2" "1503.6" "1348.5" "1396.1" "1577.3" "958.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357414389544456501" "False" "High" "IsMasterProtein" "P55212" "Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2" "0.000" "False" "45.499" "34" "10" "15" "9" "293" "33.3" "6.93" "59.85" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656" "839" "ENSG00000138794" "CASP6" "hsa:839; P55212; Q9BQE7" "TP53 Regulates Transcription of Caspase Activators and Caspases; Caspase-mediated cleavage of cytoskeletal proteins; Breakdown of the nuclear lamina" "Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Acute viral myocarditis" "10" "1" "0.984" "0.992" "1.015" "1.017" "1.035" "1.023" "1.012" "0.903" "0.633" "2177.3" "2141.6" "2159.8" "2208.8" "2213.8" "2252.9" "2226.8" "2203.2" "1965.5" "1378.7" "" "" "" "" "" "" "" "" "" "" "1930.8" "1774.0" "1884.5" "1651.9" "1846.0" "2069.6" "1882.0" "1821.1" "1802.6" "1378.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "45.416" "40" "11" "15" "11" "270" "29.7" "6.04" "49.63" "11" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "Degradation of cysteine and homocysteine" "" "1" "0" "0.988" "0.966" "0.971" "1.025" "1.007" "0.931" "1.016" "0.950" "0.772" "856.9" "846.3" "827.6" "831.7" "878.7" "863.0" "797.4" "870.8" "814.4" "661.9" "" "" "" "" "" "" "" "" "" "" "759.9" "701.0" "722.2" "622.0" "732.7" "792.8" "674.0" "719.8" "746.9" "661.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9074819377594512916" "False" "High" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "0.000" "False" "45.412" "16" "5" "10" "5" "446" "49.4" "4.92" "43.19" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "1.035" "0.984" "1.024" "1.053" "1.000" "0.978" "0.870" "0.854" "1.201" "425.3" "440.3" "418.7" "435.5" "448.0" "425.3" "415.9" "370.1" "363.2" "510.6" "" "" "" "" "" "" "" "" "" "" "377.1" "364.7" "365.3" "325.7" "373.6" "390.7" "351.5" "305.9" "333.1" "510.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.000" "False" "45.270" "21" "8" "8" "8" "426" "46.0" "8.53" "33.33" "8" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "5" "0" "0.902" "0.898" "0.959" "1.031" "1.077" "1.041" "1.051" "1.067" "1.639" "972.1" "876.8" "872.6" "931.9" "1001.9" "1047.0" "1011.5" "1022.1" "1036.7" "1593.2" "" "" "" "" "" "" "" "" "" "" "862.0" "726.3" "761.3" "697.0" "835.5" "961.8" "854.9" "844.8" "950.8" "1593.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703372283530206058" "False" "High" "IsMasterProtein" "Q9NP97" "Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3" "0.000" "False" "45.252" "40" "4" "16" "4" "96" "10.9" "7.25" "59.69" "4" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83658" "ENSG00000125971" "DYNLRB1" "B1AKR5; hsa:83658; Q5TC72; Q96IV3; Q9NP97; Q9NQM2" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "4" "0" "0.934" "0.936" "1.031" "0.954" "0.909" "0.964" "0.966" "0.924" "0.541" "1370.3" "1279.2" "1282.8" "1413.1" "1307.4" "1246.0" "1320.6" "1323.1" "1265.6" "741.0" "" "" "" "" "" "" "" "" "" "" "1215.1" "1059.6" "1119.3" "1056.8" "1090.2" "1144.6" "1116.1" "1093.7" "1160.7" "741.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "45.206" "42" "9" "13" "9" "221" "25.5" "8.65" "46.84" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "1.032" "0.959" "0.963" "1.027" "1.169" "0.872" "0.907" "0.951" "1.543" "923.5" "953.0" "886.0" "889.0" "948.0" "1079.5" "805.5" "838.0" "878.0" "1425.0" "" "" "" "" "" "" "" "" "" "" "818.9" "789.4" "773.0" "664.9" "790.5" "991.6" "680.8" "692.7" "805.2" "1425.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8383359941094889164" "False" "High" "IsMasterProtein" "Q9NV35" "Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1" "0.000" "False" "45.108" "65" "8" "16" "8" "164" "18.6" "6.14" "51.05" "8" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00293" "55270" "ENSG00000136159" "NUDT15" "A2RUR6; hsa:55270; Q32Q27; Q6P2C9; Q9NV35" "Azathioprine ADME; Phosphate bond hydrolysis by NUDT proteins" "" "2" "0" "0.962" "0.988" "0.986" "1.000" "1.060" "0.934" "1.036" "0.983" "0.768" "1299.9" "1250.7" "1283.7" "1282.2" "1299.5" "1377.6" "1214.1" "1347.2" "1277.1" "998.2" "" "" "" "" "" "" "" "" "" "" "1152.7" "1036.0" "1120.1" "958.9" "1083.6" "1265.5" "1026.1" "1113.5" "1171.3" "998.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5461850800476976864" "False" "High" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "0.000" "False" "45.020" "20" "8" "10" "7" "411" "43.2" "10.04" "36.83" "8" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "Effect of progerin on genes involved in progeria" "3" "1" "0.998" "0.994" "0.968" "1.032" "0.973" "0.971" "0.829" "0.995" "2.825" "1287.9" "1285.2" "1280.5" "1246.3" "1329.4" "1253.5" "1250.1" "1067.6" "1281.2" "3638.5" "" "" "" "" "" "" "" "" "" "" "1142.1" "1064.6" "1117.3" "932.1" "1108.5" "1151.5" "1056.5" "882.5" "1175.0" "3638.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "High" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.000" "False" "44.978" "10" "10" "11" "9" "1302" "146.1" "6.55" "40.86" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "1" "1.003" "0.949" "0.988" "0.992" "0.963" "0.913" "0.872" "0.938" "2.047" "886.8" "889.7" "841.6" "876.2" "879.7" "854.2" "809.6" "773.7" "832.3" "1815.5" "" "" "" "" "" "" "" "" "" "" "786.4" "737.0" "734.4" "655.3" "733.5" "784.7" "684.2" "639.5" "763.3" "1815.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "44.974" "35" "4" "11" "4" "118" "12.9" "5.52" "49.51" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "0.919" "0.945" "0.928" "0.903" "0.955" "0.886" "0.929" "0.942" "0.784" "2029.2" "1864.8" "1918.2" "1883.5" "1832.6" "1938.5" "1797.4" "1885.2" "1911.2" "1591.8" "" "" "" "" "" "" "" "" "" "" "1799.5" "1544.7" "1673.7" "1408.6" "1528.1" "1780.7" "1519.1" "1558.3" "1752.9" "1591.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1240749293216846131" "False" "High" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "0.000" "False" "44.962" "37" "4" "10" "4" "163" "18.2" "8.82" "45.46" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation; RHO GTPases Activate NADPH Oxidases" "Novel intracellular components of RIG-I-like receptor pathway" "6" "0" "1.042" "1.008" "1.032" "1.063" "1.087" "1.041" "1.000" "1.012" "1.272" "779.6" "812.6" "786.0" "804.7" "828.7" "847.7" "811.6" "779.3" "788.7" "991.8" "" "" "" "" "" "" "" "" "" "" "691.3" "673.2" "685.8" "601.8" "691.0" "778.7" "685.9" "644.1" "723.4" "991.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7172726289989085897" "False" "High" "IsMasterProtein" "Q8IYB5" "Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2" "0.000" "False" "44.891" "18" "7" "10" "7" "467" "50.4" "8.75" "49.84" "7" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "60682" "ENSG00000112305" "SMAP1" "hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4" "" "" "0" "0" "1.063" "1.049" "1.012" "1.029" "1.051" "1.008" "1.033" "1.093" "1.020" "970.5" "1031.5" "1018.2" "981.9" "998.9" "1019.8" "978.1" "1002.9" "1060.7" "990.3" "" "" "" "" "" "" "" "" "" "" "860.6" "854.4" "888.4" "734.3" "833.0" "936.8" "826.6" "829.0" "972.8" "990.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "44.889" "52" "6" "12" "6" "128" "14.2" "8.46" "51.29" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "mRNA processing" "4" "0" "1.048" "1.160" "1.011" "1.112" "1.108" "1.081" "1.121" "1.145" "0.554" "1920.4" "2012.8" "2227.5" "1942.0" "2136.3" "2128.2" "2075.6" "2152.8" "2199.7" "1064.3" "" "" "" "" "" "" "" "" "" "" "1702.9" "1667.3" "1943.6" "1452.3" "1781.4" "1955.0" "1754.2" "1779.4" "2017.4" "1064.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "High" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.000" "False" "44.823" "34" "6" "9" "6" "216" "24.5" "5.34" "38.44" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "Unwinding of DNA" "" "1" "0" "0.958" "0.964" "0.940" "0.963" "0.947" "1.081" "1.018" "1.033" "1.618" "967.4" "926.8" "932.8" "909.1" "931.4" "915.8" "1045.6" "985.0" "999.5" "1565.2" "" "" "" "" "" "" "" "" "" "" "857.9" "767.7" "813.9" "679.9" "776.7" "841.3" "883.7" "814.1" "916.6" "1565.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "44.821" "32" "2" "11" "2" "118" "12.6" "5.48" "50.27" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "32" "0" "1.010" "0.996" "1.079" "1.055" "1.033" "0.961" "1.109" "1.079" "0.740" "355.4" "359.1" "353.8" "383.5" "375.1" "367.1" "341.4" "394.1" "383.6" "262.9" "" "" "" "" "" "" "" "" "" "" "315.2" "297.5" "308.7" "286.8" "312.8" "337.2" "288.5" "325.7" "351.8" "262.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.000" "False" "44.801" "32" "5" "14" "5" "172" "18.8" "5.69" "58.38" "5" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "0.974" "0.977" "1.001" "0.990" "1.015" "0.963" "1.023" "1.026" "0.530" "1770.1" "1724.3" "1729.3" "1771.2" "1752.2" "1796.7" "1705.2" "1810.0" "1816.3" "938.1" "" "" "" "" "" "" "" "" "" "" "1569.7" "1428.4" "1508.9" "1324.6" "1461.1" "1650.4" "1441.2" "1496.1" "1665.8" "938.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.000" "False" "44.767" "31" "10" "13" "9" "312" "33.2" "5.43" "43.81" "10" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "1" "0.968" "1.026" "0.988" "1.010" "1.014" "1.004" "0.999" "0.981" "0.500" "1647.3" "1593.9" "1690.2" "1627.5" "1663.5" "1669.7" "1653.3" "1646.2" "1615.4" "823.2" "" "" "" "" "" "" "" "" "" "" "1460.8" "1320.3" "1474.8" "1217.2" "1387.1" "1533.8" "1397.3" "1360.7" "1481.5" "823.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "44.759" "38" "7" "9" "7" "196" "23.0" "7.39" "37.71" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "Unwinding of DNA" "" "1" "0" "0.954" "0.965" "1.017" "0.960" "0.980" "1.081" "1.011" "1.084" "1.505" "1174.3" "1120.7" "1132.7" "1194.5" "1127.6" "1150.7" "1269.5" "1186.7" "1272.9" "1767.9" "" "" "" "" "" "" "" "" "" "" "1041.4" "928.4" "988.3" "893.3" "940.3" "1057.1" "1072.9" "980.9" "1167.4" "1767.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "44.709" "31" "9" "12" "9" "325" "36.5" "5.64" "42.41" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "1.086" "0.977" "0.985" "0.999" "0.998" "1.074" "0.650" "1.078" "7.426" "587.8" "638.4" "574.2" "579.2" "587.4" "586.7" "631.1" "381.8" "633.6" "4365.0" "" "" "" "" "" "" "" "" "" "" "521.3" "528.8" "501.0" "433.1" "489.8" "539.0" "533.4" "315.6" "581.1" "4365.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "High" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.000" "False" "44.650" "28" "10" "14" "10" "338" "38.7" "7.65" "49.04" "10" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.975" "0.881" "0.970" "0.970" "0.955" "1.034" "0.949" "1.000" "1.628" "900.5" "878.4" "793.7" "873.4" "873.7" "860.2" "931.5" "855.0" "900.3" "1465.8" "" "" "" "" "" "" "" "" "" "" "798.6" "727.6" "692.5" "653.2" "728.6" "790.2" "787.3" "706.7" "825.7" "1465.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "44.564" "16" "8" "10" "8" "623" "62.7" "4.88" "32.21" "8" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "1.032" "1.015" "1.094" "0.971" "0.969" "1.117" "1.058" "1.021" "2.081" "964.4" "995.6" "978.7" "1055.1" "936.1" "934.2" "1077.5" "1020.2" "985.1" "2006.9" "" "" "" "" "" "" "" "" "" "" "855.2" "824.7" "853.9" "789.1" "780.6" "858.1" "910.7" "843.3" "903.5" "2006.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "44.551" "17" "7" "12" "7" "464" "49.2" "9.64" "46.08" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.911" "1.023" "0.858" "0.941" "0.934" "0.897" "0.918" "1.007" "1.764" "644.4" "586.8" "659.3" "552.7" "606.4" "602.0" "578.0" "591.2" "649.2" "1136.7" "" "" "" "" "" "" "" "" "" "" "571.4" "486.1" "575.3" "413.3" "505.7" "553.0" "488.5" "488.7" "595.4" "1136.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "44.545" "28" "10" "15" "8" "381" "43.0" "5.35" "52.43" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "27" "0" "0.928" "1.057" "1.011" "0.992" "0.951" "1.203" "1.041" "1.107" "1.908" "1139.8" "1057.7" "1204.2" "1152.5" "1130.2" "1084.0" "1371.2" "1186.9" "1261.4" "2174.4" "" "" "" "" "" "" "" "" "" "" "1010.8" "876.2" "1050.7" "861.9" "942.4" "995.8" "1158.9" "981.1" "1156.9" "2174.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7437253337471529535" "False" "High" "IsMasterProtein" "P02795" "Metallothionein-2 OS=Homo sapiens OX=9606 GN=MT2A PE=1 SV=1" "0.000" "False" "44.545" "66" "3" "13" "3" "61" "6.0" "7.83" "65.17" "3" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00131" "4502" "ENSG00000125148" "MT2A" "hsa:4502; P02795; Q14823; Q2HXR9; Q53XT9" "Interferon gamma signaling; Metallothioneins bind metals" "Copper homeostasis; Zinc homeostasis; Lung fibrosis" "5" "0" "0.925" "0.901" "0.942" "1.079" "1.201" "1.044" "1.044" "0.941" "0.426" "3048.6" "2819.5" "2748.2" "2871.9" "3290.0" "3662.5" "3183.7" "3182.1" "2868.6" "1299.1" "" "" "" "" "" "" "" "" "" "" "2703.4" "2335.5" "2398.0" "2147.8" "2743.4" "3364.4" "2690.7" "2630.2" "2630.9" "1299.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1208867046530031718" "False" "High" "IsMasterProtein" "P47813" "Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2" "0.000" "False" "44.533" "33" "7" "23" "1" "144" "16.5" "5.24" "65.43" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf01176" "1964" "ENSG00000173674" "EIF1AX" "B2R5U5; hsa:1964; P47813; Q0VGC2; Q5JPS5; Q5JPS6" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.922" "0.951" "0.970" "1.022" "0.901" "0.963" "0.929" "0.819" "0.619" "762.9" "703.6" "725.6" "740.0" "779.8" "687.6" "734.2" "708.6" "625.2" "472.4" "" "" "" "" "" "" "" "" "" "" "676.5" "582.8" "633.2" "553.4" "650.3" "631.7" "620.6" "585.7" "573.4" "472.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384522747761550778" "False" "High" "IsMasterProtein" "Q9NUP7" "tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens OX=9606 GN=TRMT13 PE=1 SV=2" "0.000" "False" "44.436" "20" "10" "13" "10" "481" "54.2" "8.09" "36.70" "10" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf05206, Pf05253, Pf11722" "54482" "ENSG00000122435" "TRMT13" "hsa:54482; Q5VVL0; Q9NUP7; Q9NW65" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.945" "0.948" "0.972" "0.941" "0.930" "0.888" "0.834" "0.852" "1.503" "605.5" "572.0" "573.9" "588.4" "569.9" "563.4" "537.7" "505.1" "515.7" "910.0" "" "" "" "" "" "" "" "" "" "" "537.0" "473.8" "500.8" "440.1" "475.2" "517.5" "454.4" "417.5" "473.0" "910.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548479852001098502" "False" "High" "IsMasterProtein" "P10253" "Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4" "0.000" "False" "44.410" "11" "8" "9" "8" "952" "105.3" "6.00" "37.43" "8" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00088, Pf01055, Pf13802, Pf21365" "2548" "ENSG00000171298; ENSG00000291507" "GAA" "hsa:2548; P10253; Q09GN4; Q14351; Q16302; Q8IWE7" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen storage disease type II (GAA)" "" "3" "0" "1.057" "0.981" "1.105" "1.087" "1.064" "1.055" "1.071" "0.977" "0.535" "1086.2" "1147.7" "1065.8" "1200.4" "1180.7" "1155.3" "1145.6" "1163.6" "1061.8" "581.2" "" "" "" "" "" "" "" "" "" "" "963.2" "950.7" "930.0" "897.7" "984.5" "1061.2" "968.2" "961.8" "973.8" "581.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485483695822680049" "False" "High" "IsMasterProtein" "Q9Y5R8" "Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1" "0.000" "False" "44.306" "45" "6" "8" "6" "145" "16.8" "9.16" "31.64" "6" "cell organization and biogenesis;transport" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "58485" "ENSG00000170043" "TRAPPC1" "D3DTR0; hsa:58485; Q9Y5R8" "COPII-mediated vesicle transport; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "" "3" "0" "1.078" "1.029" "1.148" "1.120" "1.065" "1.130" "1.071" "0.913" "1.204" "902.5" "972.7" "929.0" "1036.3" "1010.5" "961.6" "1019.9" "966.6" "823.8" "1086.4" "" "" "" "" "" "" "" "" "" "" "800.4" "805.7" "810.6" "775.0" "842.6" "883.3" "862.0" "799.0" "755.5" "1086.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4600920651766906085" "False" "High" "IsMasterProtein" "O14602" "Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AY PE=1 SV=4" "0.000" "False" "44.256" "33" "7" "21" "1" "144" "16.4" "5.24" "58.34" "7" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01176" "9086" "ENSG00000198692" "EIF1AY" "hsa:9086; O14602; Q9BS77" "" "Translation factors" "1" "5" "0.968" "1.031" "1.008" "0.970" "0.872" "0.847" "0.993" "0.979" "0.600" "3276.0" "3171.4" "3378.0" "3301.2" "3177.1" "2855.3" "2775.5" "3253.7" "3207.9" "1965.8" "" "" "" "" "" "" "" "" "" "" "2905.1" "2627.1" "2947.5" "2468.9" "2649.3" "2622.9" "2345.7" "2689.4" "2942.1" "1965.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "44.236" "15" "12" "18" "11" "717" "81.6" "7.14" "58.36" "12" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "mRNA Splicing - Major Pathway" "" "1" "0" "0.993" "0.990" "0.988" "0.964" "0.947" "0.931" "0.906" "0.923" "0.472" "2611.6" "2593.0" "2586.7" "2581.1" "2518.5" "2473.7" "2431.3" "2365.3" "2409.4" "1232.1" "" "" "" "" "" "" "" "" "" "" "2315.9" "2147.9" "2257.0" "1930.4" "2100.1" "2272.4" "2054.8" "1955.1" "2209.8" "1232.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819630258189506626" "False" "High" "IsMasterProtein" "P02792" "Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2" "0.000" "False" "44.225" "43" "6" "9" "6" "175" "20.0" "5.78" "36.97" "6" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2512" "ENSG00000087086" "FTL" "B2R4B9; hsa:2512; P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8" "Scavenging by Class A Receptors; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport" "Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "9" "0" "0.857" "0.887" "0.907" "0.882" "0.869" "0.925" "0.990" "0.964" "0.446" "387.7" "332.1" "343.9" "351.5" "341.8" "337.1" "358.6" "383.6" "373.5" "173.0" "" "" "" "" "" "" "" "" "" "" "343.8" "275.1" "300.1" "262.9" "285.0" "309.6" "303.1" "317.1" "342.6" "173.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "44.147" "30" "10" "13" "10" "399" "44.3" "8.07" "49.44" "10" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "35" "0" "1.008" "1.015" "1.052" "1.076" "1.078" "1.148" "1.199" "1.193" "1.426" "838.0" "845.2" "850.6" "881.6" "901.6" "903.2" "962.4" "1005.1" "999.9" "1194.9" "" "" "" "" "" "" "" "" "" "" "743.2" "700.1" "742.2" "659.3" "751.8" "829.6" "813.3" "830.8" "917.0" "1194.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235232019180232965" "False" "High" "IsMasterProtein" "A0A3B3IRV3" "Malignant T-cell-amplified sequence 2 OS=Homo sapiens OX=9606 GN=MCTS2 PE=1 SV=1" "0.000" "False" "44.081" "43" "6" "13" "1" "181" "20.3" "9.01" "48.73" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "" "ENSG00000101898" "MCTS2" "A0A3B3IRV3" "" "" "0" "0" "1.068" "0.997" "1.264" "1.208" "1.315" "1.028" "0.933" "1.082" "0.728" "50.2" "53.5" "50.0" "63.4" "60.6" "65.9" "51.5" "46.8" "54.3" "36.5" "" "" "" "" "" "" "" "" "" "" "44.5" "44.4" "43.7" "47.4" "50.5" "60.6" "43.6" "38.7" "49.8" "36.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "44.031" "46" "7" "19" "7" "145" "16.1" "10.32" "57.38" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Complement system; Cytoplasmic ribosomal proteins" "20" "0" "1.040" "0.985" "1.082" "1.074" "1.055" "1.025" "0.988" "0.997" "1.089" "1637.2" "1702.4" "1612.1" "1772.1" "1758.8" "1726.6" "1678.0" "1617.4" "1632.6" "1782.5" "" "" "" "" "" "" "" "" "" "" "1451.9" "1410.2" "1406.7" "1325.3" "1466.6" "1586.1" "1418.2" "1336.9" "1497.3" "1782.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "43.923" "17" "7" "10" "7" "476" "52.2" "6.15" "34.62" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.116" "0.931" "1.045" "0.954" "1.029" "0.979" "0.813" "0.944" "3.278" "559.8" "624.8" "521.3" "585.1" "534.0" "575.9" "547.8" "455.1" "528.7" "1835.1" "" "" "" "" "" "" "" "" "" "" "496.4" "517.6" "454.8" "437.5" "445.3" "529.0" "463.0" "376.2" "484.9" "1835.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "43.828" "28" "8" "18" "7" "238" "27.4" "11.82" "64.03" "8" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "1" "1.040" "0.964" "1.165" "1.075" "1.035" "1.225" "1.149" "1.190" "1.129" "1706.6" "1774.7" "1645.4" "1988.9" "1834.1" "1766.6" "2091.0" "1961.5" "2030.3" "1927.4" "" "" "" "" "" "" "" "" "" "" "1513.3" "1470.1" "1435.7" "1487.4" "1529.4" "1622.8" "1767.3" "1621.4" "1862.1" "1927.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058641913772226661" "False" "High" "IsMasterProtein" "Q68CJ6" "Nuclear GTPase SLIP-GC OS=Homo sapiens OX=9606 GN=NUGGC PE=1 SV=3" "0.000" "False" "43.813" "12" "10" "12" "10" "796" "91.1" "8.63" "46.51" "10" "other biological processes" "nucleus" "other molecular function" "Pf00350" "389643" "ENSG00000189233" "NUGGC" "hsa:389643; Q68CJ6; Q6ZP73" "" "" "0" "0" "0.991" "0.947" "0.864" "0.828" "0.881" "0.632" "0.535" "0.641" "2.327" "1634.5" "1620.3" "1548.4" "1412.0" "1353.5" "1439.4" "1033.3" "874.9" "1048.2" "3804.3" "" "" "" "" "" "" "" "" "" "" "1449.5" "1342.2" "1351.1" "1056.0" "1128.6" "1322.3" "873.3" "723.1" "961.3" "3804.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "43.783" "38" "7" "20" "4" "192" "21.4" "7.61" "66.95" "7" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "24" "2" "1.047" "1.096" "0.994" "1.080" "1.022" "0.957" "0.941" "1.046" "0.999" "1358.2" "1422.7" "1488.4" "1349.7" "1466.8" "1388.4" "1299.9" "1278.7" "1420.7" "1357.0" "" "" "" "" "" "" "" "" "" "" "1204.4" "1178.5" "1298.7" "1009.4" "1223.1" "1275.4" "1098.6" "1056.9" "1303.0" "1357.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "43.745" "25" "10" "10" "10" "434" "48.3" "7.93" "37.33" "10" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialic acid metabolism" "Sialylation" "2" "0" "1.012" "1.001" "0.948" "0.905" "1.004" "1.267" "1.154" "1.265" "3.153" "517.3" "523.3" "518.0" "490.2" "468.3" "519.3" "655.4" "596.7" "654.4" "1631.1" "" "" "" "" "" "" "" "" "" "" "458.7" "433.4" "452.0" "366.6" "390.5" "477.0" "553.9" "493.2" "600.1" "1631.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "43.718" "55" "6" "14" "6" "118" "13.1" "4.88" "52.14" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Inactivation of CSF3 (G-CSF) signaling; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Evasion by RSV of host interferon responses" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "22" "0" "1.019" "1.003" "0.919" "0.937" "1.014" "0.993" "1.025" "1.092" "0.760" "1588.0" "1617.7" "1593.5" "1459.5" "1488.4" "1610.3" "1576.4" "1628.2" "1733.3" "1206.5" "" "" "" "" "" "" "" "" "" "" "1408.2" "1340.0" "1390.4" "1091.5" "1241.1" "1479.2" "1332.3" "1345.8" "1589.7" "1206.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "43.669" "23" "6" "11" "6" "309" "35.0" "4.60" "39.03" "6" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "0.954" "0.965" "1.014" "0.934" "0.868" "0.919" "0.982" "0.915" "0.717" "889.7" "848.4" "858.6" "902.2" "830.6" "771.8" "817.4" "873.3" "813.9" "638.2" "" "" "" "" "" "" "" "" "" "" "788.9" "702.7" "749.2" "674.8" "692.6" "709.0" "690.9" "721.8" "746.5" "638.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651135355279393622" "False" "High" "IsMasterProtein" "Q8N2G8" "GH3 domain-containing protein OS=Homo sapiens OX=9606 GN=GHDC PE=1 SV=2" "0.000" "False" "43.627" "18" "9" "12" "9" "530" "57.5" "7.88" "37.90" "9" "" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03321" "84514" "ENSG00000167925" "GHDC" "B4DQS4; E9PDB5; hsa:84514; Q8N2G8; Q9BXM6" "Neutrophil degranulation" "" "1" "0" "1.077" "1.039" "1.147" "1.080" "1.054" "1.153" "1.112" "0.995" "0.563" "890.7" "959.6" "925.5" "1022.0" "961.9" "938.6" "1027.0" "990.7" "886.0" "501.4" "" "" "" "" "" "" "" "" "" "" "789.9" "794.9" "807.5" "764.3" "802.1" "862.2" "868.0" "818.9" "812.6" "501.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "43.600" "18" "10" "16" "4" "521" "58.7" "5.86" "47.94" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Ca2+ pathway; Calcineurin activates NFAT; DARPP-32 events" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "26" "1" "1.003" "1.004" "1.205" "1.107" "0.987" "1.131" "1.114" "0.998" "1.086" "350.2" "351.1" "351.6" "422.2" "387.8" "345.5" "396.1" "390.1" "349.5" "380.4" "" "" "" "" "" "" "" "" "" "" "310.6" "290.8" "306.8" "315.7" "323.4" "317.4" "334.8" "322.4" "320.6" "380.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874212812822634582" "False" "High" "IsMasterProtein" "Q7Z3T8" "Zinc finger FYVE domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZFYVE16 PE=1 SV=3" "0.000" "False" "43.588" "7" "10" "10" "10" "1539" "168.8" "4.82" "40.08" "10" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11979" "9765" "ENSG00000039319" "ZFYVE16" "hsa:9765; O15023; Q5H9U2; Q7LAU7; Q7Z3T8; Q86T69; Q8N5L3; Q8NEK3" "Signaling by BMP" "TGF-beta signaling pathway" "2" "0" "1.066" "1.021" "0.977" "1.018" "1.064" "1.074" "1.049" "1.006" "0.623" "917.1" "977.8" "936.8" "895.6" "933.2" "975.5" "984.7" "962.4" "923.0" "571.0" "" "" "" "" "" "" "" "" "" "" "813.3" "809.9" "817.4" "669.8" "778.1" "896.1" "832.2" "795.5" "846.5" "571.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.000" "False" "43.582" "15" "5" "14" "5" "463" "51.8" "6.99" "60.24" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "Neutrophil degranulation; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER" "" "4" "0" "1.069" "1.100" "1.095" "1.078" "1.153" "1.095" "1.124" "1.037" "0.606" "1652.9" "1766.2" "1817.9" "1810.4" "1781.2" "1906.2" "1810.3" "1858.6" "1714.6" "1002.4" "" "" "" "" "" "" "" "" "" "" "1465.8" "1463.0" "1586.2" "1354.0" "1485.3" "1751.0" "1530.0" "1536.2" "1572.6" "1002.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693736025540312441" "False" "High" "IsMasterProtein" "P0CG12" "Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1" "0.000" "False" "43.498" "15" "6" "10" "6" "524" "51.4" "12.41" "40.41" "6" "" "nucleus" "" "" "" "ENSG00000286140" "DERPC" "A8MYX8; P0CG12; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "" "" "0" "0" "1.050" "1.021" "1.098" "1.102" "1.038" "0.983" "0.907" "0.914" "0.685" "989.1" "1038.7" "1009.7" "1085.9" "1089.7" "1026.3" "971.8" "897.5" "903.6" "677.6" "" "" "" "" "" "" "" "" "" "" "877.1" "860.4" "881.0" "812.1" "908.6" "942.8" "821.3" "741.8" "828.7" "677.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8998736333335138172" "False" "High" "IsMasterProtein" "Q08623" "Pseudouridine-5'-phosphatase OS=Homo sapiens OX=9606 GN=PUDP PE=1 SV=3" "0.000" "False" "43.367" "32" "6" "16" "6" "228" "25.2" "5.31" "56.39" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf13419" "8226" "ENSG00000130021" "PUDP" "B2R7X6; B4DV93; B7Z6Q3; E9PAV8; F5GWZ2; hsa:8226; Q08623; Q53F84; Q96EB8" "Pyrimidine salvage" "" "1" "0" "1.023" "1.045" "1.065" "1.127" "1.068" "1.067" "1.110" "1.013" "0.483" "1787.9" "1828.2" "1868.1" "1903.4" "2015.2" "1910.3" "1906.8" "1985.0" "1811.9" "863.2" "" "" "" "" "" "" "" "" "" "" "1585.4" "1514.4" "1630.0" "1423.5" "1680.4" "1754.8" "1611.6" "1640.7" "1661.7" "863.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485123881553311665" "False" "High" "IsMasterProtein" "Q8TEB1" "DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1" "0.000" "False" "43.341" "16" "8" "10" "8" "546" "61.6" "6.40" "36.08" "8" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80344" "ENSG00000100897; ENSG00000284796" "DCAF11" "B3KQ83; D3DS56; hsa:80344; Q5D039; Q86U00; Q86U39; Q8NDN2; Q8TEB1; Q9H2J0; Q9H3A3; Q9H5C9" "Neddylation" "Ciliary landscape" "2" "0" "1.109" "0.986" "1.066" "1.105" "0.957" "1.038" "1.092" "1.005" "0.684" "825.5" "915.6" "814.2" "879.7" "911.8" "790.0" "857.1" "901.4" "829.7" "565.0" "" "" "" "" "" "" "" "" "" "" "732.0" "758.4" "710.4" "657.9" "760.3" "725.7" "724.4" "745.1" "760.9" "565.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.000" "False" "43.338" "38" "4" "13" "4" "125" "14.1" "8.25" "54.95" "4" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial protein import" "Mitochondrial complex IV assembly" "2" "0" "0.983" "1.012" "0.963" "1.004" "1.045" "1.026" "1.068" "1.022" "0.386" "2440.6" "2398.8" "2468.8" "2350.9" "2450.4" "2550.1" "2505.0" "2606.0" "2493.6" "941.2" "" "" "" "" "" "" "" "" "" "" "2164.3" "1987.1" "2154.2" "1758.1" "2043.3" "2342.6" "2117.1" "2154.1" "2287.0" "941.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.000" "False" "43.297" "19" "8" "11" "8" "483" "54.2" "9.06" "42.21" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.990" "0.963" "0.997" "1.026" "1.098" "0.822" "0.792" "0.789" "0.545" "1256.6" "1243.8" "1210.0" "1252.3" "1289.5" "1379.5" "1033.6" "995.7" "991.3" "684.4" "" "" "" "" "" "" "" "" "" "" "1114.3" "1030.3" "1055.8" "936.5" "1075.2" "1267.2" "873.5" "823.0" "909.1" "684.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917272071926626278" "False" "High" "IsMasterProtein" "Q99797" "Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2" "0.000" "False" "43.284" "18" "11" "14" "11" "713" "80.6" "7.05" "49.23" "11" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01432" "4285" "ENSG00000027001" "MIPEP" "hsa:4285; Q5JV15; Q5T9Q9; Q96G65; Q99797" "" "13q12.12 copy number variation" "1" "0" "1.014" "0.997" "1.001" "1.011" "1.035" "1.022" "1.049" "1.013" "1.029" "945.7" "958.5" "943.3" "946.5" "956.2" "978.9" "966.3" "992.2" "957.7" "973.4" "" "" "" "" "" "" "" "" "" "" "838.6" "794.0" "823.1" "707.9" "797.4" "899.2" "816.7" "820.2" "878.3" "973.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "43.266" "23" "5" "12" "5" "222" "25.1" "5.97" "53.13" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "10" "0" "1.011" "0.990" "1.087" "1.032" "0.976" "1.073" "1.040" "0.997" "0.583" "970.4" "980.8" "960.4" "1055.0" "1001.2" "947.4" "1041.5" "1009.5" "967.5" "565.6" "" "" "" "" "" "" "" "" "" "" "860.5" "812.5" "838.0" "789.0" "834.8" "870.3" "880.3" "834.5" "887.4" "565.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949096695489977400" "False" "High" "IsMasterProtein" "P05386" "Large ribosomal subunit protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1" "0.000" "False" "43.172" "29" "3" "17" "1" "114" "11.5" "4.32" "61.40" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;other molecular function" "Pf00428" "6176" "ENSG00000137818" "RPLP1" "A6NIB2; hsa:6176; P05386" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.107" "0.970" "1.164" "1.256" "1.197" "1.127" "1.105" "1.127" "0.494" "127.5" "141.2" "123.7" "148.4" "160.1" "152.6" "143.7" "140.9" "143.7" "63.0" "" "" "" "" "" "" "" "" "" "" "113.1" "116.9" "108.0" "111.0" "133.5" "140.2" "121.4" "116.4" "131.8" "63.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "High" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.000" "False" "43.138" "63" "7" "12" "7" "90" "10.3" "6.29" "45.65" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "Mitochondrial protein degradation; Mitochondrial protein import" "" "2" "0" "0.924" "0.876" "1.057" "0.907" "1.012" "0.947" "0.932" "0.909" "0.267" "1192.4" "1102.2" "1044.7" "1260.1" "1081.7" "1206.5" "1129.7" "1111.1" "1083.9" "318.9" "" "" "" "" "" "" "" "" "" "" "1057.4" "913.0" "911.5" "942.4" "902.0" "1108.3" "954.8" "918.4" "994.1" "318.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "43.101" "39" "7" "13" "5" "162" "18.8" "8.66" "40.70" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "" "2" "1" "1.028" "0.992" "1.048" "1.071" "1.091" "1.059" "0.902" "1.029" "4.171" "541.0" "555.9" "536.9" "566.7" "579.3" "590.2" "572.9" "488.1" "556.8" "2256.7" "" "" "" "" "" "" "" "" "" "" "479.7" "460.5" "468.5" "423.8" "483.1" "542.2" "484.2" "403.5" "510.7" "2256.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "43.067" "47" "5" "10" "5" "93" "10.4" "4.93" "38.16" "5" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.981" "0.891" "0.982" "0.904" "0.950" "0.920" "0.937" "0.927" "0.486" "1029.5" "1010.3" "917.5" "1010.8" "930.9" "978.3" "947.5" "965.2" "954.1" "500.0" "" "" "" "" "" "" "" "" "" "" "913.0" "836.9" "800.6" "756.0" "776.3" "898.7" "800.8" "797.8" "875.0" "500.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.000" "False" "43.057" "37" "5" "10" "5" "194" "21.1" "5.01" "31.25" "5" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "1.030" "1.049" "1.095" "0.991" "1.069" "1.008" "1.074" "1.096" "0.794" "419.5" "431.9" "440.3" "459.5" "415.8" "448.4" "422.9" "450.5" "459.8" "333.0" "" "" "" "" "" "" "" "" "" "" "372.0" "357.8" "384.1" "343.7" "346.7" "411.9" "357.4" "372.4" "421.7" "333.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "43.048" "17" "11" "13" "9" "607" "66.3" "5.31" "38.52" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "" "2" "0" "1.026" "0.903" "0.950" "0.928" "1.016" "0.952" "0.799" "0.922" "3.074" "684.0" "701.9" "617.8" "649.5" "634.9" "695.3" "651.0" "546.5" "630.5" "2102.7" "" "" "" "" "" "" "" "" "" "" "606.6" "581.4" "539.0" "485.8" "529.4" "638.7" "550.2" "451.7" "578.3" "2102.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "High" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.000" "False" "43.028" "6" "10" "12" "10" "1817" "197.5" "6.40" "42.95" "10" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "1" "0" "0.959" "0.988" "0.940" "0.969" "0.952" "0.946" "0.939" "0.956" "1.272" "1226.2" "1175.7" "1211.6" "1153.1" "1188.6" "1167.8" "1159.6" "1151.7" "1172.4" "1560.1" "" "" "" "" "" "" "" "" "" "" "1087.4" "973.9" "1057.2" "862.4" "991.1" "1072.8" "980.1" "951.9" "1075.2" "1560.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.000" "False" "43.010" "26" "8" "15" "8" "325" "37.5" "7.06" "50.01" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "0.971" "1.012" "0.928" "0.989" "1.030" "0.970" "1.006" "1.027" "0.640" "2369.8" "2301.6" "2398.7" "2198.1" "2342.7" "2441.6" "2298.6" "2382.9" "2433.1" "1517.6" "" "" "" "" "" "" "" "" "" "" "2101.5" "1906.6" "2093.0" "1643.9" "1953.5" "2242.9" "1942.7" "1969.7" "2231.5" "1517.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3335218336630157461" "False" "High" "IsMasterProtein" "Q9UFN0" "Protein NipSnap homolog 3A OS=Homo sapiens OX=9606 GN=NIPSNAP3A PE=1 SV=2" "0.000" "False" "42.942" "28" "7" "15" "7" "247" "28.4" "9.16" "52.15" "7" "" "cytosol;mitochondrion" "" "Pf07978" "25934" "ENSG00000136783" "NIPSNAP3A" "A6NM55; hsa:25934; Q5VX32; Q9BRV7; Q9H843; Q9P083; Q9UFN0" "" "" "0" "0" "0.977" "1.000" "0.920" "0.977" "1.117" "1.000" "1.063" "1.168" "0.469" "1783.4" "1743.2" "1784.2" "1640.8" "1741.8" "1992.7" "1784.2" "1896.6" "2083.3" "836.7" "" "" "" "" "" "" "" "" "" "" "1581.5" "1444.0" "1556.8" "1227.1" "1452.4" "1830.5" "1507.9" "1567.7" "1910.6" "836.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970453667170528269" "False" "High" "IsMasterProtein" "P16083" "Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=5" "0.000" "False" "42.934" "23" "4" "6" "4" "231" "25.9" "6.29" "30.21" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02525" "4835" "ENSG00000124588" "NQO2" "B2R492; P16083; Q5TD04" "Phase I - Functionalization of compounds" "Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "2" "0" "1.020" "1.024" "0.973" "0.998" "1.029" "1.049" "1.066" "1.002" "0.507" "1164.8" "1188.7" "1193.3" "1133.6" "1162.4" "1198.3" "1222.0" "1241.3" "1166.6" "590.1" "" "" "" "" "" "" "" "" "" "" "1032.9" "984.6" "1041.2" "847.8" "969.2" "1100.8" "1032.8" "1026.0" "1069.9" "590.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-715832753700784142" "False" "High" "IsMasterProtein" "P22830" "Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2" "0.000" "False" "42.928" "23" "9" "11" "9" "423" "47.8" "8.73" "38.37" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00762" "2235" "ENSG00000066926" "FECH" "A8KA72; hsa:2235; P22830; Q8IXN1; Q8NAN0" "Mitochondrial protein degradation; Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "1.032" "1.018" "1.055" "1.029" "1.060" "1.103" "1.095" "1.025" "0.643" "912.2" "941.4" "929.0" "962.4" "938.3" "967.0" "1006.1" "998.8" "935.0" "586.8" "" "" "" "" "" "" "" "" "" "" "808.9" "779.8" "810.6" "719.7" "782.5" "888.3" "850.3" "825.6" "857.6" "586.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5062141414675458558" "False" "High" "IsMasterProtein" "Q9P0L0" "Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3" "0.000" "False" "42.904" "29" "7" "17" "6" "249" "27.9" "8.62" "54.91" "7" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9218" "ENSG00000101558" "VAPA" "A6NDZ0; D3DUI3; hsa:9218; O75453; Q5U0E7; Q9P0L0; Q9UBZ2" "Neutrophil degranulation; Sphingolipid de novo biosynthesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "Exercise-induced circadian regulation; Cholesterol metabolism" "5" "1" "0.979" "0.987" "0.938" "0.947" "0.953" "0.968" "0.962" "0.993" "0.389" "1970.9" "1929.6" "1944.3" "1849.3" "1866.9" "1877.3" "1908.5" "1896.9" "1958.0" "766.5" "" "" "" "" "" "" "" "" "" "" "1747.7" "1598.4" "1696.5" "1383.0" "1556.8" "1724.5" "1613.0" "1567.9" "1795.8" "766.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208996323542288612" "False" "High" "IsMasterProtein" "Q8N5P1" "Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2" "0.000" "False" "42.820" "22" "6" "14" "6" "291" "33.6" "8.28" "47.95" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18345" "84524" "ENSG00000144161" "ZC3H8" "hsa:84524; Q8N5P1; Q9BZ75" "RNA polymerase II transcribes snRNA genes" "2q13 copy number variation syndrome" "2" "0" "0.888" "0.895" "0.795" "0.877" "0.892" "0.806" "0.885" "0.896" "0.543" "2531.7" "2248.0" "2266.8" "2013.8" "2219.8" "2257.9" "2040.1" "2240.8" "2268.0" "1374.4" "" "" "" "" "" "" "" "" "" "" "2245.1" "1862.1" "1977.9" "1506.0" "1851.0" "2074.2" "1724.2" "1852.2" "2080.0" "1374.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "High" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.000" "False" "42.743" "29" "3" "12" "3" "134" "15.3" "4.53" "53.05" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.014" "0.956" "1.042" "0.984" "0.994" "1.043" "1.014" "0.987" "0.475" "1179.4" "1196.3" "1127.5" "1229.2" "1160.6" "1172.6" "1229.8" "1195.7" "1163.5" "559.9" "" "" "" "" "" "" "" "" "" "" "1045.9" "990.9" "983.8" "919.3" "967.8" "1077.1" "1039.4" "988.4" "1067.1" "559.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2129800861400375686" "False" "High" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "0.000" "False" "42.731" "49" "4" "8" "4" "97" "11.0" "5.16" "33.42" "4" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; O60220; Q6IRW6" "Mitochondrial protein import" "" "1" "0" "1.026" "1.023" "1.030" "1.078" "0.956" "0.980" "0.993" "0.988" "0.552" "939.2" "963.2" "960.9" "966.9" "1012.3" "898.0" "920.7" "932.3" "928.0" "518.3" "" "" "" "" "" "" "" "" "" "" "832.8" "797.9" "838.4" "723.1" "844.1" "825.0" "778.1" "770.6" "851.1" "518.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3185905528720532686" "False" "High" "IsMasterProtein" "P01903" "HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2" "0.000" "False" "42.703" "26" "5" "9" "4" "254" "28.6" "5.00" "39.77" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00993, Pf07654" "3122" "ENSG00000204287; ENSG00000206308; ENSG00000226260; ENSG00000227993; ENSG00000228987; ENSG00000230726; ENSG00000234794; ENSG00000277263" "HLA-DRA" "A2BET4; hsa:3122; P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "Allograft rejection; PI3K/AKT/mTOR - vitamin D3 signaling; Ebola virus infection in host; Male infertility; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; 11p11.2 copy number variation syndrome" "16" "1" "1.058" "0.973" "0.977" "1.091" "1.050" "1.092" "1.059" "1.108" "0.621" "852.2" "901.6" "829.2" "832.2" "929.8" "894.7" "930.7" "902.2" "944.3" "529.3" "" "" "" "" "" "" "" "" "" "" "755.7" "746.8" "723.5" "622.4" "775.3" "821.9" "786.6" "745.8" "866.1" "529.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9088787272925242729" "False" "High" "IsMasterProtein" "Q9C0D3" "Protein zyg-11 homolog B OS=Homo sapiens OX=9606 GN=ZYG11B PE=1 SV=2" "0.000" "False" "42.695" "14" "8" "9" "8" "744" "83.9" "6.86" "34.08" "8" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "79699" "ENSG00000162378" "ZYG11B" "hsa:79699; Q8N2X3; Q9C0D3; Q9H8L8" "" "Ciliary landscape; Hijack of ubiquitination by SARS-CoV-2" "2" "0" "1.021" "0.943" "1.179" "1.086" "1.010" "1.025" "1.029" "0.895" "0.778" "376.2" "384.0" "354.9" "443.6" "408.5" "379.8" "385.6" "387.0" "336.7" "292.6" "" "" "" "" "" "" "" "" "" "" "333.6" "318.1" "309.7" "331.7" "340.6" "348.9" "325.9" "319.9" "308.8" "292.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.000" "False" "42.665" "26" "7" "10" "7" "293" "32.6" "9.88" "37.50" "7" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "0.959" "0.980" "1.000" "0.944" "0.996" "0.936" "0.920" "0.888" "0.439" "1070.3" "1026.1" "1049.4" "1070.0" "1009.9" "1065.5" "1001.6" "984.9" "950.4" "469.6" "" "" "" "" "" "" "" "" "" "" "949.1" "849.9" "915.7" "800.2" "842.1" "978.8" "846.5" "814.1" "871.7" "469.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "42.654" "27" "8" "9" "8" "367" "41.7" "7.25" "33.67" "8" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Synthesis of PC" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "7" "0" "0.968" "1.006" "0.948" "0.981" "0.972" "0.909" "0.922" "0.892" "0.928" "539.7" "522.2" "542.7" "511.6" "529.3" "524.6" "490.8" "497.8" "481.3" "500.6" "" "" "" "" "" "" "" "" "" "" "478.6" "432.6" "473.5" "382.6" "441.3" "481.9" "414.8" "411.4" "441.4" "500.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610453000666898366" "False" "High" "IsMasterProtein" "Q6RFH5" "WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1" "0.000" "False" "42.626" "20" "6" "9" "6" "385" "42.4" "8.32" "31.71" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "54663" "ENSG00000133316" "WDR74" "A8K8G5; hsa:54663; Q6RFH5; Q9BRC9; Q9H6X8; Q9NVY2" "" "" "0" "0" "0.994" "0.920" "1.075" "0.956" "0.945" "1.246" "1.112" "1.102" "1.018" "424.5" "422.0" "390.7" "456.4" "405.6" "401.3" "529.0" "472.1" "467.6" "432.3" "" "" "" "" "" "" "" "" "" "" "376.4" "349.6" "340.9" "341.3" "338.2" "368.7" "447.1" "390.3" "428.8" "432.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "42.616" "40" "7" "13" "7" "210" "22.3" "6.40" "50.31" "7" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "Cytosolic sulfonation of small molecules" "" "1" "0" "1.008" "1.019" "0.982" "1.022" "1.022" "0.974" "1.059" "0.875" "0.640" "1235.2" "1245.0" "1258.9" "1212.6" "1261.7" "1262.9" "1203.7" "1307.7" "1081.1" "790.8" "" "" "" "" "" "" "" "" "" "" "1095.3" "1031.3" "1098.5" "906.9" "1052.1" "1160.1" "1017.3" "1080.9" "991.5" "790.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "42.549" "29" "5" "15" "5" "188" "21.6" "11.72" "58.56" "5" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.104" "1.062" "1.150" "1.162" "1.107" "1.118" "1.114" "1.089" "0.688" "1155.5" "1276.0" "1226.6" "1329.1" "1343.0" "1279.2" "1291.6" "1287.7" "1258.9" "795.4" "" "" "" "" "" "" "" "" "" "" "1024.7" "1057.0" "1070.3" "994.0" "1119.9" "1175.1" "1091.6" "1064.4" "1154.6" "795.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "506200805167063951" "False" "High" "IsMasterProtein" "P42229" "Signal transducer and activator of transcription 5A OS=Homo sapiens OX=9606 GN=STAT5A PE=1 SV=1" "0.000" "False" "42.510" "11" "9" "12" "9" "794" "90.6" "6.39" "46.55" "9" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6776" "ENSG00000126561" "STAT5A" "hsa:6776; P42229; Q1KLZ6" "Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Nuclear signaling by ERBB4; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; Nuclear events stimulated by ALK signaling in cancer; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "IL-5 signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Puberty (Stage 2 of 4); Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; TYROBP causal network in microglia; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; Interferon type I signaling pathways; ErbB signaling pathway" "54" "0" "1.022" "0.973" "1.025" "0.950" "1.100" "0.914" "0.354" "1.085" "14.986" "503.2" "514.5" "489.7" "515.7" "478.0" "553.7" "459.9" "177.9" "546.0" "7541.0" "" "" "" "" "" "" "" "" "" "" "446.2" "426.2" "427.3" "385.7" "398.6" "508.7" "388.7" "147.1" "500.8" "7541.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721253402515192355" "False" "High" "IsMasterProtein" "O95544" "NAD kinase OS=Homo sapiens OX=9606 GN=NADK PE=1 SV=1" "0.000" "False" "42.492" "15" "5" "7" "5" "446" "49.2" "6.47" "26.97" "5" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01513, Pf20143" "65220" "ENSG00000008130" "NADK" "A6NNN3; A8K296; B7Z434; F5GXR5; hsa:65220; O95544; Q5QPS4; Q9H2P2; Q9H931" "Nicotinate metabolism" "NAD+ metabolism; 1p36 copy number variation syndrome" "3" "0" "1.126" "1.053" "1.106" "1.122" "1.135" "1.067" "1.118" "1.028" "0.594" "769.2" "866.1" "810.0" "850.8" "863.4" "873.4" "820.5" "860.3" "790.8" "456.5" "" "" "" "" "" "" "" "" "" "" "682.1" "717.4" "706.8" "636.3" "719.9" "802.3" "693.5" "711.1" "725.3" "456.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751278663907923034" "False" "High" "IsMasterProtein" "Q9UFG5" "UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2" "0.000" "False" "42.431" "55" "5" "15" "5" "118" "12.9" "5.07" "55.64" "5" "" "" "" "Pf15136" "148223" "ENSG00000119559" "C19orf25" "B3KQN6; hsa:148223; Q8N9R7; Q8WV94; Q9UFG5" "" "" "0" "0" "0.979" "0.913" "1.101" "1.020" "0.908" "1.049" "0.997" "0.989" "0.555" "1173.5" "1149.4" "1071.6" "1291.9" "1196.7" "1065.0" "1230.9" "1169.8" "1161.1" "651.2" "" "" "" "" "" "" "" "" "" "" "1040.7" "952.1" "935.0" "966.2" "997.9" "978.3" "1040.3" "966.9" "1064.9" "651.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "42.430" "40" "4" "16" "4" "98" "11.1" "7.56" "65.03" "4" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "Neutrophil degranulation" "" "1" "0" "0.927" "0.966" "0.932" "0.960" "0.988" "0.940" "0.972" "0.985" "0.537" "1893.5" "1755.5" "1828.5" "1763.9" "1818.5" "1870.8" "1779.9" "1839.7" "1865.7" "1017.7" "" "" "" "" "" "" "" "" "" "" "1679.1" "1454.1" "1595.4" "1319.1" "1516.4" "1718.5" "1504.3" "1520.6" "1711.1" "1017.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119829718007226858" "False" "High" "IsMasterProtein" "Q9UJX5" "Anaphase-promoting complex subunit 4 OS=Homo sapiens OX=9606 GN=ANAPC4 PE=1 SV=2" "0.000" "False" "42.419" "9" "7" "9" "7" "808" "92.1" "5.53" "33.24" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12894, Pf12896" "29945" "ENSG00000053900" "ANAPC4" "A8K8H1; E9PCR4; hsa:29945; Q6PCC6; Q9NSH6; Q9UJX5" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.070" "0.911" "0.942" "0.882" "0.834" "0.848" "0.886" "0.986" "1.191" "936.8" "1002.5" "853.7" "882.3" "826.2" "781.1" "794.0" "829.8" "923.5" "1115.8" "" "" "" "" "" "" "" "" "" "" "830.7" "830.4" "744.9" "659.9" "689.0" "717.6" "671.1" "685.9" "846.9" "1115.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.000" "False" "42.407" "12" "8" "8" "8" "802" "92.2" "8.18" "29.92" "8" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "mRNA Splicing - Major Pathway" "" "1" "0" "1.001" "0.957" "1.054" "0.914" "0.962" "0.952" "0.772" "0.861" "3.176" "658.1" "658.7" "630.0" "694.0" "601.4" "633.1" "626.3" "508.0" "566.6" "2090.0" "" "" "" "" "" "" "" "" "" "" "583.6" "545.6" "549.7" "519.0" "501.5" "581.6" "529.3" "419.9" "519.6" "2090.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "42.404" "32" "7" "21" "5" "208" "22.8" "5.73" "73.27" "7" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Smooth Muscle Contraction" "Ciliary landscape" "2" "0" "0.975" "0.908" "0.954" "1.015" "1.077" "1.007" "0.975" "1.052" "0.673" "836.0" "814.8" "759.4" "797.4" "848.4" "900.5" "842.0" "814.8" "879.8" "562.8" "" "" "" "" "" "" "" "" "" "" "741.4" "674.9" "662.6" "596.4" "707.4" "827.2" "711.7" "673.4" "806.9" "562.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "42.354" "19" "9" "14" "9" "551" "60.2" "5.68" "46.76" "9" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "101" "0" "1.116" "1.057" "1.102" "1.095" "1.022" "1.040" "0.896" "0.990" "3.345" "474.5" "529.6" "501.4" "523.0" "519.7" "484.8" "493.3" "425.2" "469.5" "1587.0" "" "" "" "" "" "" "" "" "" "" "420.7" "438.7" "437.5" "391.1" "433.3" "445.3" "417.0" "351.4" "430.6" "1587.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6354667477089484627" "False" "High" "IsMasterProtein" "Q5T2E6" "Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1" "0.000" "False" "42.288" "13" "9" "11" "9" "689" "78.7" "6.60" "39.06" "9" "other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf08427" "79591" "ENSG00000120029" "ARMH3" "hsa:79591; Q2TB87; Q5T2E6; Q9H8Z9" "" "" "0" "0" "0.983" "0.996" "0.982" "0.972" "1.043" "0.958" "0.989" "0.861" "0.506" "912.3" "896.7" "908.9" "896.2" "886.5" "951.5" "874.1" "902.6" "785.9" "462.1" "" "" "" "" "" "" "" "" "" "" "809.0" "742.7" "793.1" "670.3" "739.2" "874.1" "738.7" "746.0" "720.8" "462.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2810950685469585295" "False" "High" "IsMasterProtein" "Q2TBE0" "CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4" "0.000" "False" "42.281" "10" "9" "10" "9" "894" "103.7" "8.65" "37.98" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf04676, Pf04677" "143884" "ENSG00000152404" "CWF19L2" "A4FU66; A4FU67; A4FU68; A8KAD6; hsa:143884; Q2TBE0; Q6PHW1; Q96MI1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.014" "0.926" "1.068" "0.970" "0.942" "0.936" "0.838" "0.893" "1.522" "906.3" "919.3" "839.1" "968.0" "879.1" "853.9" "848.0" "759.4" "808.9" "1379.4" "" "" "" "" "" "" "" "" "" "" "803.7" "761.5" "732.2" "723.9" "733.0" "784.4" "716.7" "627.7" "741.9" "1379.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.000" "False" "42.232" "26" "4" "14" "4" "218" "21.7" "6.57" "61.10" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "Ub-specific processing proteases; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation; HATs acetylate histones" "" "11" "0" "1.086" "0.993" "1.215" "1.028" "0.920" "0.999" "0.959" "0.936" "0.692" "1033.6" "1122.8" "1026.2" "1255.4" "1062.4" "951.0" "1032.9" "990.8" "967.4" "715.0" "" "" "" "" "" "" "" "" "" "" "916.6" "930.1" "895.4" "938.9" "885.9" "873.6" "873.0" "819.0" "887.3" "715.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "High" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.000" "False" "42.145" "26" "7" "11" "7" "309" "34.5" "8.98" "40.44" "7" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "1.043" "0.981" "1.007" "0.980" "1.099" "1.079" "0.691" "1.027" "5.807" "369.1" "384.8" "362.0" "371.9" "361.7" "405.8" "398.4" "255.1" "379.0" "2143.6" "" "" "" "" "" "" "" "" "" "" "327.3" "318.8" "315.8" "278.1" "301.6" "372.7" "336.7" "210.9" "347.6" "2143.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.000" "False" "42.135" "5" "8" "9" "8" "2266" "252.3" "6.60" "36.01" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "Gastric cancer network 2" "8" "0" "1.111" "0.997" "1.160" "1.115" "1.025" "1.165" "1.033" "1.138" "0.645" "297.4" "330.3" "296.5" "344.9" "331.6" "304.8" "346.4" "307.1" "338.4" "191.9" "" "" "" "" "" "" "" "" "" "" "263.7" "273.6" "258.7" "257.9" "276.5" "280.0" "292.8" "253.9" "310.3" "191.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115257495252240726" "False" "High" "IsMasterProtein" "P82909" "Alpha-ketoglutarate dehydrogenase component 4 OS=Homo sapiens OX=9606 GN=KGD4 PE=1 SV=2" "0.000" "False" "42.044" "45" "3" "10" "3" "103" "11.5" "9.99" "42.94" "3" "other metabolic processes" "other membranes;mitochondrion" "" "" "92259" "ENSG00000134056; ENSG00000278461" "KGD4" "hsa:92259; P82909; Q9H2H4" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.999" "0.937" "1.093" "0.993" "0.932" "0.992" "1.011" "0.983" "0.425" "662.6" "662.2" "620.9" "724.3" "658.0" "617.6" "657.1" "669.6" "651.3" "281.9" "" "" "" "" "" "" "" "" "" "" "587.6" "548.5" "541.7" "541.7" "548.7" "567.4" "555.3" "553.5" "597.3" "281.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "42.026" "10" "8" "11" "6" "780" "79.2" "5.02" "41.70" "8" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "1" "1.010" "1.000" "1.015" "1.030" "1.051" "0.950" "1.042" "0.983" "0.811" "972.5" "982.6" "972.2" "987.5" "1001.3" "1022.3" "923.9" "1013.2" "955.5" "788.9" "" "" "" "" "" "" "" "" "" "" "862.4" "813.9" "848.3" "738.5" "835.0" "939.1" "780.8" "837.5" "876.3" "788.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "42.021" "16" "6" "7" "5" "457" "49.6" "5.12" "28.52" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Signaling by FGFR1 in disease; Regulation of HSF1-mediated heat shock response; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "Oxidative damage response" "5" "0" "1.052" "1.112" "0.967" "1.036" "0.956" "0.996" "1.023" "0.998" "0.648" "744.5" "783.3" "827.9" "720.0" "771.4" "711.9" "741.2" "761.2" "742.7" "482.3" "" "" "" "" "" "" "" "" "" "" "660.2" "648.9" "722.3" "538.4" "643.3" "654.0" "626.5" "629.2" "681.1" "482.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6107269265140402008" "False" "High" "IsMasterProtein" "P10109" "Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1" "0.000" "False" "42.000" "38" "7" "16" "7" "184" "19.4" "5.83" "50.18" "7" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00111" "2230" "ENSG00000137714" "FDX1" "B0YJ14; hsa:2230; P10109; Q53YD6" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "Iron-sulfur cluster biogenesis" "6" "0" "0.962" "0.938" "0.928" "0.923" "0.972" "0.929" "0.951" "0.967" "0.462" "3027.4" "2912.5" "2839.1" "2809.6" "2795.5" "2942.4" "2813.6" "2879.9" "2928.8" "1397.6" "" "" "" "" "" "" "" "" "" "" "2684.6" "2412.6" "2477.3" "2101.2" "2331.0" "2702.9" "2377.9" "2380.5" "2686.1" "1397.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "984760743341076196" "False" "High" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=IFT25 PE=1 SV=1" "0.000" "False" "41.966" "48" "4" "13" "4" "144" "16.3" "5.03" "70.42" "4" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "6" "0" "0.973" "0.962" "1.041" "1.006" "1.048" "1.087" "1.089" "0.989" "0.709" "1786.6" "1737.9" "1719.6" "1860.5" "1798.0" "1872.0" "1941.4" "1946.4" "1766.5" "1266.0" "" "" "" "" "" "" "" "" "" "" "1584.3" "1439.6" "1500.4" "1391.4" "1499.3" "1719.7" "1640.8" "1608.9" "1620.1" "1266.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "41.880" "20" "10" "14" "10" "513" "57.5" "7.18" "47.05" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.047" "0.945" "0.991" "1.021" "1.015" "1.046" "0.950" "0.932" "1.706" "1226.5" "1283.7" "1159.0" "1215.4" "1251.8" "1244.7" "1282.5" "1164.8" "1142.9" "2092.6" "" "" "" "" "" "" "" "" "" "" "1087.6" "1063.4" "1011.3" "908.9" "1043.8" "1143.4" "1084.0" "962.8" "1048.2" "2092.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "41.859" "20" "7" "9" "7" "480" "53.1" "6.19" "36.30" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "Viral mRNA Translation; Mitochondrial RNA degradation" "VEGFA-VEGFR2 signaling" "3" "0" "1.035" "1.062" "1.021" "1.027" "1.017" "0.813" "0.373" "0.787" "9.576" "388.5" "401.9" "412.4" "396.7" "398.8" "395.1" "315.9" "144.9" "305.6" "3719.9" "" "" "" "" "" "" "" "" "" "" "344.5" "332.9" "359.9" "296.7" "332.6" "362.9" "267.0" "119.8" "280.3" "3719.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378984088295691653" "False" "High" "IsMasterProtein" "P49023" "Paxillin OS=Homo sapiens OX=9606 GN=PXN PE=1 SV=3" "0.000" "False" "41.846" "16" "9" "14" "9" "591" "64.5" "6.19" "47.21" "9" "cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00412, Pf03535" "5829" "ENSG00000089159" "PXN" "B2RAI3; B7ZMB4; hsa:5829; O14970; O14971; O60360; P49023; Q5HYA4" "VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton; GDNF signaling; HDAC6 interactions in the central nervous system" "21" "0" "0.927" "0.887" "0.785" "0.825" "0.774" "0.745" "0.888" "0.997" "0.476" "1365.0" "1265.6" "1210.4" "1071.3" "1126.8" "1056.5" "1017.1" "1212.2" "1361.4" "649.7" "" "" "" "" "" "" "" "" "" "" "1210.4" "1048.3" "1056.2" "801.2" "939.6" "970.5" "859.6" "1002.0" "1248.6" "649.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7755566090060093643" "False" "High" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "0.000" "False" "41.841" "25" "8" "10" "8" "325" "34.3" "8.54" "40.40" "8" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Peroxisomal protein import; Synthesis of Ketone Bodies" "Amino acid metabolism" "3" "0" "0.980" "0.908" "0.921" "0.868" "0.839" "0.833" "0.910" "0.933" "0.419" "1962.4" "1922.9" "1781.0" "1807.1" "1702.8" "1647.1" "1634.4" "1785.1" "1830.8" "822.5" "" "" "" "" "" "" "" "" "" "" "1740.2" "1592.8" "1554.0" "1351.5" "1419.9" "1513.1" "1381.3" "1475.5" "1679.1" "822.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3656789324422396877" "False" "High" "IsMasterProtein" "P11912" "B-cell antigen receptor complex-associated protein alpha chain OS=Homo sapiens OX=9606 GN=CD79A PE=1 SV=2" "0.000" "False" "41.797" "21" "3" "8" "3" "226" "25.0" "5.00" "35.70" "3" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00047, Pf02189" "973" "ENSG00000105369" "CD79A" "A0N775; hsa:973; P11912; Q53FB8" "CD22 mediated BCR regulation; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "1.079" "1.069" "0.960" "1.071" "1.156" "1.008" "1.015" "1.025" "0.486" "537.8" "580.5" "574.8" "516.3" "576.0" "621.6" "542.3" "545.8" "551.1" "261.6" "" "" "" "" "" "" "" "" "" "" "476.9" "480.9" "501.5" "386.1" "480.3" "571.0" "458.3" "451.2" "505.5" "261.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622690060897357887" "False" "High" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "0.000" "False" "41.769" "42" "5" "24" "5" "106" "12.2" "9.35" "92.04" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "" "Electron transport chain: OXPHOS system in mitochondria" "1" "0" "0.902" "0.995" "0.911" "1.057" "0.912" "0.816" "0.946" "0.973" "0.396" "2288.9" "2065.1" "2278.2" "2085.2" "2418.6" "2088.4" "1867.6" "2165.4" "2228.2" "905.5" "" "" "" "" "" "" "" "" "" "" "2029.8" "1710.6" "1987.8" "1559.5" "2016.8" "1918.4" "1578.4" "1789.9" "2043.6" "905.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-329240465840991374" "False" "High" "IsMasterProtein" "Q6GMV3" "Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1" "0.000" "False" "41.765" "31" "4" "17" "4" "140" "15.8" "9.10" "65.63" "4" "" "" "other molecular function" "Pf01981" "391356" "ENSG00000184924" "PTRHD1" "Q6GMV3" "" "" "0" "0" "0.994" "0.977" "0.944" "0.984" "1.005" "0.950" "1.000" "0.963" "0.420" "2600.5" "2585.1" "2540.3" "2455.1" "2558.8" "2613.6" "2471.1" "2600.3" "2505.0" "1092.6" "" "" "" "" "" "" "" "" "" "" "2306.1" "2141.4" "2216.5" "1836.1" "2133.7" "2400.9" "2088.5" "2149.4" "2297.4" "1092.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "41.734" "15" "7" "8" "7" "581" "62.5" "9.45" "33.42" "7" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "1.021" "0.928" "1.144" "1.011" "0.954" "1.118" "1.009" "1.000" "0.933" "355.5" "363.0" "329.9" "406.6" "359.4" "339.1" "397.4" "358.8" "355.6" "331.7" "" "" "" "" "" "" "" "" "" "" "315.2" "300.7" "287.8" "304.1" "299.7" "311.5" "335.9" "296.6" "326.1" "331.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "41.645" "8" "12" "14" "12" "1299" "150.0" "5.54" "45.36" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.039" "0.938" "1.000" "1.016" "0.909" "1.021" "0.894" "0.968" "1.912" "1251.9" "1300.5" "1174.0" "1252.0" "1272.1" "1138.2" "1278.1" "1119.1" "1212.4" "2393.9" "" "" "" "" "" "" "" "" "" "" "1110.2" "1077.3" "1024.4" "936.3" "1060.8" "1045.6" "1080.2" "925.0" "1112.0" "2393.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848605729142375391" "False" "High" "IsMasterProtein" "P00813" "Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3" "0.000" "False" "41.604" "23" "10" "17" "10" "363" "40.7" "5.95" "56.44" "10" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00962" "100" "ENSG00000196839" "ADA" "hsa:100; P00813; Q53F92; Q6LA59" "Ribavirin ADME; Purine salvage; Defective ADA disrupts (deoxy)adenosine deamination" "" "3" "0" "1.009" "0.997" "1.093" "1.010" "1.018" "1.012" "0.986" "0.924" "0.447" "2524.2" "2546.1" "2515.6" "2757.8" "2549.8" "2570.5" "2555.2" "2488.6" "2331.5" "1128.5" "" "" "" "" "" "" "" "" "" "" "2238.4" "2109.0" "2195.0" "2062.4" "2126.2" "2361.3" "2159.5" "2057.0" "2138.3" "1128.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114366665604462397" "False" "High" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.000" "False" "41.601" "18" "8" "8" "8" "481" "55.6" "7.49" "34.21" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.989" "0.957" "0.997" "0.990" "1.008" "1.031" "1.060" "0.947" "0.703" "880.8" "871.5" "843.3" "877.9" "872.1" "887.6" "908.0" "934.0" "834.4" "619.5" "" "" "" "" "" "" "" "" "" "" "781.1" "721.9" "735.8" "656.5" "727.2" "815.3" "767.4" "772.0" "765.2" "619.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.000" "False" "41.544" "30" "6" "12" "6" "221" "23.6" "7.03" "54.15" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.022" "1.034" "1.055" "1.018" "1.067" "1.065" "1.118" "1.105" "0.671" "1018.9" "1041.6" "1053.5" "1074.9" "1037.2" "1087.0" "1085.2" "1138.8" "1126.1" "683.8" "" "" "" "" "" "" "" "" "" "" "903.6" "862.8" "919.2" "803.9" "864.9" "998.5" "917.2" "941.3" "1032.7" "683.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.000" "False" "41.537" "8" "9" "9" "9" "1294" "141.0" "8.40" "31.18" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "7q11.23 copy number variation syndrome" "8" "0" "1.026" "0.926" "0.952" "0.836" "0.849" "0.894" "0.677" "1.039" "4.543" "324.0" "332.4" "300.0" "308.4" "271.0" "274.9" "289.5" "219.5" "336.6" "1471.8" "" "" "" "" "" "" "" "" "" "" "287.3" "275.3" "261.8" "230.6" "226.0" "252.6" "244.7" "181.4" "308.7" "1471.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.000" "False" "41.524" "14" "6" "8" "6" "471" "54.5" "5.00" "31.62" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "0.989" "0.975" "1.147" "1.055" "1.008" "1.010" "0.959" "0.979" "0.802" "740.7" "732.5" "722.2" "849.8" "781.7" "746.7" "748.5" "710.1" "725.3" "594.0" "" "" "" "" "" "" "" "" "" "" "656.9" "606.8" "630.1" "635.6" "651.8" "685.9" "632.6" "586.9" "665.2" "594.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2708632979130541749" "False" "High" "IsMasterProtein" "Cont_P02584" "Profilin-1 OS=Bos taurus OX=9913 GN=PFN1 PE=1 SV=2" "0.000" "True" "41.514" "31" "4" "49" "1" "140" "15.0" "8.28" "126.87" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00235" "102175326; 104993965; 109573782; 513895" "ENSBGRG00000026249; ENSBIXG00000014601; ENSBIXG00005028693; ENSBTAG00000004915; ENSCHIG00000025972; ENSMMSG00000006925" "PFN1" "A0A212D7Q6; A0A452G587; A0A4W2IHQ6; A0A5N3WG60; A0A5N3X3I9; A0A6B0S5H7; A0A6J0Z611; A0A6P3HSX5; A0A6P5DHW6; A0A8B9YVA5; A0A8C6DAC0; bbis:104993965; biu:109573782; bta:513895; chx:102175326; P02584; Q3ZCH4; Q5E942" "PCP/CE pathway; RHO GTPases Activate Formins" "" "2" "0" "1.187" "0.917" "1.167" "1.082" "0.948" "1.091" "1.107" "0.980" "0.791" "132.7" "157.5" "121.7" "154.8" "143.6" "125.7" "144.7" "146.9" "130.0" "104.9" "" "" "" "" "" "" "" "" "" "" "117.7" "130.5" "106.2" "115.8" "119.7" "115.5" "122.3" "121.4" "119.2" "104.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5255338936326354588" "False" "High" "IsMasterProtein" "O75448" "Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1" "0.000" "False" "41.475" "10" "8" "8" "8" "989" "110.2" "6.95" "32.53" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11277" "9862" "ENSG00000008838" "MED24" "A8K4S5; B3KMR9; hsa:9862; O75448; Q14143; Q9NNY5" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.005" "0.976" "1.094" "1.035" "1.062" "1.024" "0.954" "1.034" "1.679" "678.0" "681.4" "661.9" "741.8" "701.5" "720.2" "694.5" "646.8" "701.3" "1138.7" "" "" "" "" "" "" "" "" "" "" "601.3" "564.4" "577.6" "554.7" "584.9" "661.6" "587.0" "534.6" "643.2" "1138.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "41.473" "25" "4" "10" "4" "210" "23.1" "8.69" "38.41" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "3" "0" "1.051" "1.103" "1.002" "1.031" "0.978" "0.875" "1.037" "0.932" "0.589" "160.4" "168.6" "176.8" "160.7" "165.4" "156.8" "140.3" "166.2" "149.5" "94.4" "" "" "" "" "" "" "" "" "" "" "142.2" "139.6" "154.3" "120.1" "137.9" "144.0" "118.6" "137.4" "137.1" "94.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "41.455" "43" "7" "11" "7" "167" "18.0" "9.48" "43.53" "7" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Maturation of replicase proteins" "Iron-sulfur cluster biogenesis" "2" "0" "0.951" "0.985" "0.953" "0.920" "0.965" "0.897" "0.995" "0.945" "0.446" "1688.9" "1606.3" "1663.3" "1609.1" "1553.2" "1629.1" "1514.5" "1681.2" "1596.4" "753.2" "" "" "" "" "" "" "" "" "" "" "1497.7" "1330.6" "1451.3" "1203.4" "1295.2" "1496.5" "1280.0" "1389.6" "1464.1" "753.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.000" "False" "41.441" "13" "8" "15" "8" "808" "87.1" "9.19" "53.40" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "TBC/RABGAPs" "" "1" "0" "0.952" "0.964" "1.006" "0.957" "0.953" "1.032" "1.018" "1.015" "0.689" "744.7" "709.2" "718.0" "748.9" "713.0" "709.6" "768.7" "758.2" "756.1" "512.9" "" "" "" "" "" "" "" "" "" "" "660.4" "587.5" "626.5" "560.1" "594.5" "651.9" "649.6" "626.7" "693.4" "512.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.000" "False" "41.394" "33" "5" "11" "5" "195" "21.7" "7.74" "46.12" "5" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "1.024" "0.983" "0.888" "0.929" "0.916" "0.902" "0.959" "0.923" "0.713" "1353.2" "1385.2" "1330.3" "1201.6" "1256.8" "1239.1" "1220.6" "1297.4" "1249.5" "965.4" "" "" "" "" "" "" "" "" "" "" "1199.9" "1147.4" "1160.7" "898.6" "1048.0" "1138.3" "1031.6" "1072.4" "1145.9" "965.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494037614751494800" "False" "High" "IsMasterProtein" "O94900" "Thymocyte selection-associated high mobility group box protein TOX OS=Homo sapiens OX=9606 GN=TOX PE=1 SV=3" "0.000" "False" "41.394" "13" "6" "9" "4" "526" "57.5" "7.33" "36.92" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00505" "9760" "ENSG00000198846" "TOX" "hsa:9760; O94900; Q96AV5" "" "Mesodermal commitment pathway; Development and heterogeneity of the ILC family; Orexin receptor pathway" "3" "0" "0.980" "1.021" "0.978" "1.037" "1.039" "0.888" "0.941" "0.921" "0.751" "766.9" "751.5" "783.2" "750.2" "795.2" "796.9" "680.8" "721.5" "706.5" "575.6" "" "" "" "" "" "" "" "" "" "" "680.1" "622.5" "683.4" "561.0" "663.1" "732.1" "575.4" "596.4" "647.9" "575.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "41.382" "12" "9" "11" "9" "724" "83.5" "6.16" "40.43" "9" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "G alpha (q) signalling events; Extra-nuclear estrogen signaling; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOC GTPase cycle; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "154" "0" "0.969" "0.964" "0.969" "0.883" "0.908" "0.926" "0.873" "0.904" "1.733" "1292.4" "1252.5" "1245.7" "1252.4" "1140.9" "1174.1" "1197.3" "1127.9" "1167.8" "2240.0" "" "" "" "" "" "" "" "" "" "" "1146.1" "1037.5" "1086.9" "936.7" "951.3" "1078.6" "1011.9" "932.3" "1071.0" "2240.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "41.353" "49" "8" "12" "8" "158" "18.4" "10.30" "43.60" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "SARS-CoV-2 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "21" "0" "1.129" "1.145" "1.165" "1.211" "0.961" "1.032" "1.080" "1.144" "2.409" "1258.6" "1421.6" "1441.4" "1466.3" "1523.9" "1209.3" "1298.5" "1358.8" "1439.3" "3031.8" "" "" "" "" "" "" "" "" "" "" "1116.1" "1177.6" "1257.7" "1096.6" "1270.7" "1110.9" "1097.4" "1123.2" "1320.1" "3031.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "41.310" "47" "5" "12" "5" "87" "10.1" "6.04" "43.22" "5" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "Mitochondrial protein import" "" "1" "0" "0.949" "0.980" "1.037" "1.013" "1.081" "1.080" "1.041" "0.992" "0.418" "1066.4" "1011.8" "1045.4" "1105.8" "1079.9" "1152.4" "1151.7" "1109.9" "1058.3" "445.9" "" "" "" "" "" "" "" "" "" "" "945.6" "838.1" "912.2" "827.0" "900.5" "1058.6" "973.4" "917.4" "970.6" "445.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "41.256" "19" "6" "11" "6" "279" "30.5" "5.07" "49.73" "6" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "0.934" "0.961" "0.937" "0.870" "1.022" "1.001" "1.001" "1.038" "0.614" "1309.9" "1223.4" "1258.2" "1227.7" "1140.2" "1338.7" "1311.5" "1311.5" "1359.6" "804.6" "" "" "" "" "" "" "" "" "" "" "1161.6" "1013.4" "1097.8" "918.2" "950.7" "1229.8" "1108.4" "1084.1" "1247.0" "804.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736314326613788604" "False" "High" "IsMasterProtein" "P62277" "Small ribosomal subunit protein uS15 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "0.000" "False" "41.251" "51" "8" "15" "8" "151" "17.2" "10.54" "46.03" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.038" "0.968" "0.953" "0.974" "0.789" "0.866" "0.899" "1.032" "1.844" "731.3" "759.0" "707.7" "696.8" "712.0" "577.3" "633.5" "657.1" "755.0" "1348.2" "" "" "" "" "" "" "" "" "" "" "648.5" "628.7" "617.5" "521.1" "593.7" "530.4" "535.4" "543.1" "692.4" "1348.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.000" "False" "41.243" "21" "7" "8" "7" "403" "47.3" "9.36" "33.90" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "" "3" "0" "0.892" "0.914" "0.953" "0.917" "0.831" "0.825" "0.760" "0.819" "1.922" "923.5" "824.1" "844.6" "880.0" "846.9" "767.2" "761.5" "702.2" "756.4" "1774.7" "" "" "" "" "" "" "" "" "" "" "819.0" "682.6" "736.9" "658.1" "706.2" "704.7" "643.6" "580.4" "693.7" "1774.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8204162643568548731" "False" "High" "IsMasterProtein" "Q9HD47" "Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1" "0.000" "False" "41.203" "38" "5" "7" "5" "186" "20.4" "4.94" "33.11" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04603" "29098" "ENSG00000108961" "RANGRF" "D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2" "Phase 0 - rapid depolarisation" "" "1" "0" "1.144" "1.170" "1.290" "1.225" "1.314" "1.190" "1.027" "0.994" "1.098" "176.1" "201.4" "206.1" "227.2" "215.8" "231.5" "209.5" "180.9" "175.1" "193.3" "" "" "" "" "" "" "" "" "" "" "156.2" "166.8" "179.9" "169.9" "180.0" "212.6" "177.1" "149.6" "160.6" "193.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "41.199" "27" "7" "13" "5" "288" "32.3" "9.72" "45.43" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "HATs acetylate histones" "" "1" "0" "0.980" "0.929" "0.964" "0.811" "0.670" "0.637" "0.844" "0.821" "0.701" "828.9" "812.4" "770.5" "799.2" "671.9" "555.2" "527.7" "699.5" "680.6" "580.8" "" "" "" "" "" "" "" "" "" "" "735.1" "672.9" "672.3" "597.7" "560.3" "510.0" "446.0" "578.2" "624.2" "580.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8070932965104358622" "False" "High" "IsMasterProtein" "Q86YS7" "C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1" "0.000" "False" "41.162" "10" "10" "14" "10" "1000" "110.4" "5.69" "48.47" "10" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00168" "9847" "ENSG00000111731" "C2CD5" "B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "0.969" "0.986" "1.018" "0.983" "0.973" "0.948" "0.966" "0.909" "0.826" "974.1" "944.3" "960.5" "992.1" "957.9" "947.7" "923.8" "941.2" "885.3" "804.8" "" "" "" "" "" "" "" "" "" "" "863.8" "782.2" "838.1" "741.9" "798.8" "870.6" "780.7" "778.0" "811.9" "804.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-729542664091126034" "False" "High" "IsMasterProtein" "Q93008" "Ubiquitin carboxyl-terminal hydrolase 9X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4" "0.000" "False" "41.146" "5" "13" "14" "13" "2554" "290.3" "5.80" "41.02" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8239" "ENSG00000124486" "USP9X" "hsa:8239; O75550; Q8WWT3; Q8WX12; Q93008" "Ub-specific processing proteases; Amyloid fiber formation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Peroxisomal protein import; RHOV GTPase cycle; RHOU GTPase cycle; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Ciliopathies; Bardet-Biedl syndrome" "9" "0" "0.945" "0.910" "0.878" "0.936" "0.955" "0.967" "0.788" "0.890" "3.888" "837.6" "791.4" "761.8" "735.7" "784.2" "799.6" "810.2" "660.2" "745.1" "3256.5" "" "" "" "" "" "" "" "" "" "" "742.8" "655.6" "664.7" "550.2" "654.0" "734.5" "684.7" "545.7" "683.4" "3256.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6009675423733223461" "False" "High" "IsMasterProtein" "Q96B54" "Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2" "0.000" "False" "41.138" "30" "4" "6" "4" "188" "20.5" "4.17" "30.42" "4" "" "" "other molecular function" "" "126299" "ENSG00000131116" "ZNF428" "hsa:126299; O95054; Q6X3Y3; Q96B54" "" "" "0" "0" "0.999" "0.986" "1.024" "1.082" "1.069" "0.986" "0.955" "0.919" "0.435" "943.4" "942.3" "930.6" "966.3" "1021.0" "1008.4" "930.0" "900.8" "866.9" "410.4" "" "" "" "" "" "" "" "" "" "" "836.6" "780.6" "812.0" "722.7" "851.3" "926.3" "786.0" "744.6" "795.1" "410.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821659264702231707" "False" "High" "IsMasterProtein" "P13284" "Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3" "0.000" "False" "41.033" "24" "4" "29" "4" "250" "27.9" "4.88" "86.56" "4" "other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03227" "10437" "ENSG00000216490" "IFI30" "hsa:10437; P13284; Q76MF9; Q8NEI4; Q8WU77; Q9UL08" "MHC class II antigen presentation; Interferon gamma signaling" "" "2" "0" "0.994" "0.935" "0.887" "0.932" "0.878" "0.854" "0.916" "0.897" "0.569" "1270.2" "1262.7" "1187.2" "1126.5" "1184.1" "1115.0" "1084.9" "1163.5" "1139.1" "723.0" "" "" "" "" "" "" "" "" "" "" "1126.4" "1046.0" "1035.9" "842.4" "987.4" "1024.3" "916.9" "961.7" "1044.7" "723.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "41.000" "18" "10" "12" "10" "565" "63.1" "5.72" "42.03" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "0.971" "1.002" "0.965" "1.053" "0.925" "0.871" "0.886" "0.969" "1.643" "1272.3" "1236.0" "1274.6" "1227.9" "1339.6" "1176.6" "1108.8" "1127.1" "1233.2" "2089.9" "" "" "" "" "" "" "" "" "" "" "1128.2" "1023.8" "1112.2" "918.3" "1117.1" "1080.8" "937.1" "931.7" "1131.0" "2089.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2273417600798469774" "False" "High" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "0.000" "False" "40.999" "6" "8" "9" "8" "1443" "160.8" "6.40" "32.99" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "7" "0" "0.987" "0.914" "1.034" "0.876" "0.899" "0.901" "0.878" "0.794" "0.944" "303.7" "299.9" "277.4" "314.1" "266.0" "273.0" "273.7" "266.5" "241.0" "286.6" "" "" "" "" "" "" "" "" "" "" "269.3" "248.4" "242.1" "234.9" "221.8" "250.8" "231.4" "220.3" "221.1" "286.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117675378851989584" "False" "High" "IsMasterProtein" "P56270" "Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1" "0.000" "False" "40.963" "17" "9" "18" "7" "477" "48.6" "8.95" "60.19" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "4150" "ENSG00000103495" "MAZ" "A8QJL9; C6G496; G5E927; H3BQD6; hsa:4150; P56270; Q15703; Q8NFN7; Q99443" "" "16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "3" "0.957" "0.998" "0.826" "0.956" "0.979" "0.890" "0.995" "1.062" "0.562" "558.1" "534.0" "556.8" "461.1" "533.8" "546.2" "497.0" "555.2" "592.6" "313.5" "" "" "" "" "" "" "" "" "" "" "494.9" "442.4" "485.9" "344.9" "445.1" "501.8" "420.0" "458.9" "543.5" "313.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7104112355135180301" "False" "High" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.000" "False" "40.947" "43" "7" "9" "7" "194" "21.8" "8.15" "36.37" "7" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "RAB geranylgeranylation" "" "1" "0" "1.044" "1.029" "1.064" "1.105" "1.078" "1.041" "1.059" "1.001" "0.794" "1042.5" "1088.4" "1072.2" "1109.6" "1152.2" "1123.7" "1085.5" "1104.0" "1043.8" "827.3" "" "" "" "" "" "" "" "" "" "" "924.4" "901.5" "935.6" "829.9" "960.8" "1032.2" "917.4" "912.5" "957.3" "827.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.000" "False" "40.936" "8" "10" "10" "10" "1461" "155.9" "7.42" "36.80" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.058" "1.008" "1.073" "0.976" "1.011" "0.965" "0.866" "0.983" "2.228" "1590.8" "1682.7" "1604.3" "1707.3" "1552.3" "1607.8" "1535.1" "1376.9" "1563.9" "3544.8" "" "" "" "" "" "" "" "" "" "" "1410.7" "1393.8" "1399.8" "1276.9" "1294.4" "1477.0" "1297.4" "1138.1" "1434.3" "3544.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7727085808198553563" "False" "High" "IsMasterProtein" "P30291" "Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2" "0.000" "False" "40.908" "15" "7" "9" "7" "646" "71.6" "6.77" "36.49" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7465" "ENSG00000166483" "WEE1" "B3KVE1; D3DQV0; hsa:7465; P30291" "Factors involved in megakaryocyte development and platelet production; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control" "11" "0" "1.147" "0.997" "1.340" "1.184" "1.173" "1.312" "1.263" "1.261" "1.122" "551.0" "632.0" "549.4" "738.6" "652.2" "646.1" "722.7" "695.9" "694.7" "618.2" "" "" "" "" "" "" "" "" "" "" "488.6" "523.5" "479.4" "552.4" "543.8" "593.5" "610.8" "575.2" "637.2" "618.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385362476021457625" "False" "High" "IsMasterProtein" "B3KNS4" "Endogenous retrovirus group K3 member 1 OS=Homo sapiens OX=9606 GN=ERVK3-1 PE=1 SV=1" "0.000" "False" "40.899" "39" "4" "10" "4" "109" "11.6" "7.78" "44.40" "4" "" "" "" "Pf15695" "" "ENSG00000142396" "ERVK3-1" "B3KNS4" "" "" "0" "0" "1.039" "1.044" "1.065" "1.107" "1.010" "0.977" "1.071" "1.046" "0.593" "955.1" "992.8" "996.7" "1017.7" "1056.9" "964.8" "933.1" "1023.0" "999.5" "566.5" "" "" "" "" "" "" "" "" "" "" "847.0" "822.3" "869.7" "761.1" "881.3" "886.3" "788.6" "845.6" "916.7" "566.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "40.820" "24" "7" "10" "7" "346" "36.2" "8.79" "37.01" "7" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Citric acid cycle (TCA cycle)" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "3" "0" "0.996" "0.984" "1.075" "1.050" "0.950" "1.513" "1.260" "1.260" "1.640" "842.5" "838.7" "829.0" "905.6" "884.3" "800.5" "1274.6" "1061.5" "1061.8" "1382.1" "" "" "" "" "" "" "" "" "" "" "747.1" "694.7" "723.4" "677.2" "737.4" "735.4" "1077.3" "877.4" "973.8" "1382.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4479122024934742870" "False" "High" "IsMasterProtein" "Q92934" "Bcl2-associated agonist of cell death OS=Homo sapiens OX=9606 GN=BAD PE=1 SV=3" "0.000" "False" "40.794" "33" "4" "5" "4" "168" "18.4" "7.15" "24.90" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf10514" "572" "ENSG00000002330" "BAD" "hsa:572; O14803; Q6FH21; Q92934" "NRAGE signals death through JNK; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of BAD and translocation to mitochondria" "Leptin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; NO/cGMP/PKG mediated neuroprotection; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent)" "42" "0" "0.989" "0.962" "1.027" "0.997" "1.037" "1.045" "1.136" "1.089" "0.488" "465.7" "460.7" "447.9" "478.3" "464.1" "482.8" "486.6" "529.1" "507.3" "227.2" "" "" "" "" "" "" "" "" "" "" "412.9" "381.6" "390.8" "357.7" "387.0" "443.5" "411.2" "437.4" "465.2" "227.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "40.790" "30" "6" "24" "6" "182" "20.5" "6.79" "77.94" "6" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "WNT ligand biogenesis and trafficking" "" "1" "0" "0.965" "1.011" "0.965" "0.970" "1.046" "1.014" "1.039" "1.032" "0.497" "2696.7" "2602.2" "2726.7" "2603.5" "2615.8" "2821.8" "2734.2" "2800.6" "2782.2" "1340.4" "" "" "" "" "" "" "" "" "" "" "2391.3" "2155.6" "2379.2" "1947.1" "2181.2" "2592.1" "2310.8" "2314.9" "2551.7" "1340.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "317033728722267888" "False" "High" "IsMasterProtein" "P34913" "Bifunctional epoxide hydrolase 2 OS=Homo sapiens OX=9606 GN=EPHX2 PE=1 SV=2" "0.000" "False" "40.752" "21" "8" "9" "8" "555" "62.6" "6.28" "34.66" "8" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00561, Pf00702" "2053" "ENSG00000120915" "EPHX2" "B2Z3B1; B3KTU8; B3KUA0; G3V134; hsa:2053; J3KPH7; P34913; Q16764; Q9HBJ1; Q9HBJ2" "Peroxisomal protein import; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET); Biosynthesis of maresins" "Eicosanoid metabolism via cytochrome P450 monooxygenases pathway; Familial hyperlipidemia type 2; ALA oxylipin metabolism; Linoleic acid oxylipin metabolism; Docosahexaenoic acid oxylipin metabolism; Arachidonic acid (AA, ARA) oxylipin metabolism; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "12" "0" "1.032" "1.019" "1.048" "1.052" "0.979" "1.030" "1.111" "0.967" "0.525" "533.4" "550.6" "543.7" "558.8" "560.9" "522.0" "549.3" "592.6" "516.0" "280.1" "" "" "" "" "" "" "" "" "" "" "473.0" "456.1" "474.4" "417.9" "467.7" "479.5" "464.2" "489.8" "473.2" "280.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7454062146017555339" "False" "High" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.000" "False" "40.736" "9" "8" "9" "8" "993" "112.8" "5.57" "34.40" "8" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "" "2" "0" "1.014" "0.894" "1.028" "0.898" "0.865" "0.876" "0.758" "0.767" "3.114" "857.2" "869.1" "766.3" "880.9" "769.7" "741.8" "750.7" "649.8" "657.9" "2669.2" "" "" "" "" "" "" "" "" "" "" "760.1" "719.9" "668.6" "658.8" "641.9" "681.5" "634.5" "537.1" "603.4" "2669.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.000" "False" "40.573" "46" "7" "13" "7" "135" "15.5" "9.85" "50.31" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.009" "1.058" "1.010" "1.092" "0.955" "0.978" "1.005" "1.095" "1.090" "859.9" "868.0" "909.8" "868.7" "938.9" "821.5" "841.3" "864.5" "942.0" "936.9" "" "" "" "" "" "" "" "" "" "" "762.6" "719.0" "793.8" "649.7" "782.9" "754.7" "711.0" "714.6" "864.0" "936.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827069170954705052" "False" "High" "IsMasterProtein" "Q9UKJ3" "G patch domain-containing protein 8 OS=Homo sapiens OX=9606 GN=GPATCH8 PE=1 SV=2" "0.000" "False" "40.570" "6" "7" "10" "7" "1502" "164.1" "8.66" "30.11" "7" "" "nucleus" "other molecular function" "Pf01585" "23131" "ENSG00000186566" "GPATCH8" "B9EGP9; hsa:23131; O60300; Q8TB99; Q9UKJ3" "" "" "0" "0" "0.898" "0.959" "0.975" "0.921" "0.919" "0.972" "0.993" "0.954" "0.768" "886.6" "795.9" "850.1" "864.7" "816.2" "815.2" "862.0" "880.9" "845.5" "681.3" "" "" "" "" "" "" "" "" "" "" "786.2" "659.3" "741.8" "646.7" "680.6" "748.9" "728.5" "728.1" "775.4" "681.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552389438880602085" "False" "High" "IsMasterProtein" "Q7L5Y1" "Mitochondrial enolase superfamily member 1 OS=Homo sapiens OX=9606 GN=ENOSF1 PE=1 SV=1" "0.000" "False" "40.561" "21" "10" "11" "10" "443" "49.8" "6.48" "37.54" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf02746, Pf13378" "55556" "ENSG00000132199" "ENOSF1" "A6NMP3; A8K9R5; B3KSL6; B3KXE4; D3DUH0; hsa:55556; Q15407; Q15594; Q15595; Q6ZS08; Q7L5Y1; Q9HAS5; Q9HAS6" "" "" "0" "0" "1.034" "1.014" "1.075" "1.071" "1.085" "1.068" "1.054" "0.976" "0.633" "960.2" "993.2" "973.6" "1032.2" "1028.7" "1042.2" "1025.9" "1012.0" "937.0" "607.8" "" "" "" "" "" "" "" "" "" "" "851.4" "822.7" "849.5" "771.9" "857.8" "957.4" "867.0" "836.5" "859.3" "607.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "High" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.000" "False" "40.527" "19" "8" "8" "8" "491" "56.9" "7.02" "35.72" "8" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "16p11.2 distal deletion syndrome" "3" "0" "1.059" "1.011" "1.083" "1.022" "1.028" "1.062" "0.964" "1.034" "1.652" "1049.3" "1111.0" "1060.9" "1136.8" "1072.4" "1078.6" "1114.3" "1011.4" "1085.3" "1733.4" "" "" "" "" "" "" "" "" "" "" "930.5" "920.3" "925.7" "850.2" "894.3" "990.8" "941.8" "836.0" "995.4" "1733.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "40.520" "12" "4" "7" "4" "433" "45.5" "8.69" "28.10" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "tRNA processing in the nucleus" "" "1" "0" "1.005" "1.069" "1.091" "1.008" "0.968" "1.042" "0.947" "0.957" "2.139" "444.6" "446.8" "475.2" "484.9" "448.0" "430.4" "463.5" "421.3" "425.5" "951.1" "" "" "" "" "" "" "" "" "" "" "394.3" "370.1" "414.6" "362.7" "373.5" "395.4" "391.7" "348.2" "390.2" "951.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "High" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.000" "False" "40.497" "8" "6" "9" "6" "803" "90.0" "7.09" "29.99" "6" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "RHOV GTPase cycle; RHOU GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; Ephrin signaling; RHOA GTPase cycle; CDC42 GTPase cycle; G alpha (12/13) signalling events; RHOQ GTPase cycle; RHOJ GTPase cycle; EGFR downregulation" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "14" "0" "0.943" "0.906" "0.995" "0.893" "0.925" "0.896" "0.638" "0.897" "6.534" "521.1" "491.6" "471.9" "518.6" "465.4" "481.8" "467.0" "332.2" "467.6" "3404.4" "" "" "" "" "" "" "" "" "" "" "462.1" "407.2" "411.8" "387.8" "388.1" "442.6" "394.7" "274.6" "428.8" "3404.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "40.477" "37" "8" "13" "8" "237" "26.3" "7.84" "51.46" "8" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "0.992" "1.038" "1.013" "1.109" "1.054" "1.043" "1.048" "0.993" "0.867" "1208.5" "1199.4" "1253.9" "1224.0" "1340.4" "1273.2" "1260.1" "1266.2" "1199.8" "1047.7" "" "" "" "" "" "" "" "" "" "" "1071.7" "993.5" "1094.1" "915.4" "1117.7" "1169.6" "1065.0" "1046.6" "1100.3" "1047.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "40.380" "31" "7" "20" "7" "173" "18.8" "6.68" "64.77" "7" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "XBP1(S) activates chaperone genes" "" "1" "0" "0.985" "1.117" "0.985" "1.028" "1.016" "1.040" "1.104" "1.137" "0.448" "2310.5" "2275.3" "2581.2" "2275.3" "2374.5" "2347.9" "2402.9" "2550.3" "2627.8" "1035.7" "" "" "" "" "" "" "" "" "" "" "2048.9" "1884.7" "2252.2" "1701.6" "1980.0" "2156.8" "2030.8" "2108.0" "2410.1" "1035.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6704752873658697689" "False" "High" "IsMasterProtein" "P37268" "Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1" "0.000" "False" "40.372" "16" "6" "9" "6" "417" "48.1" "6.54" "33.83" "6" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00494" "2222" "ENSG00000079459; ENSG00000284967" "FDFT1" "B3KQ95; B4DJE5; B4DT56; B7Z1J3; hsa:2222; P37268; Q96GT0" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism; 8p23.1 copy number variation syndrome" "12" "0" "1.146" "0.980" "1.123" "1.148" "0.991" "1.062" "1.078" "1.022" "0.925" "432.8" "495.9" "424.0" "485.9" "496.9" "428.9" "459.5" "466.4" "442.3" "400.3" "" "" "" "" "" "" "" "" "" "" "383.8" "410.8" "369.9" "363.4" "414.4" "394.0" "388.4" "385.5" "405.7" "400.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "40.319" "7" "10" "11" "10" "1478" "164.9" "5.22" "37.30" "10" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "" "2" "0" "1.024" "1.000" "1.005" "1.057" "0.893" "0.992" "0.816" "0.963" "3.688" "848.2" "868.2" "848.6" "852.8" "896.4" "757.4" "841.5" "691.9" "816.9" "3127.8" "" "" "" "" "" "" "" "" "" "" "752.2" "719.1" "740.4" "637.8" "747.5" "695.8" "711.2" "571.9" "749.2" "3127.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.000" "False" "40.295" "47" "5" "7" "5" "166" "18.4" "8.29" "37.29" "5" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "Oxidative stress response" "3" "0" "1.028" "1.070" "0.966" "1.211" "1.000" "0.989" "1.063" "1.141" "0.510" "983.6" "1011.3" "1052.3" "950.0" "1191.0" "983.6" "972.6" "1045.6" "1122.3" "501.3" "" "" "" "" "" "" "" "" "" "" "872.2" "837.7" "918.2" "710.5" "993.2" "903.6" "822.0" "864.2" "1029.3" "501.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "40.294" "61" "7" "19" "7" "122" "14.2" "6.81" "54.45" "7" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.938" "0.903" "0.910" "0.869" "0.831" "0.825" "0.906" "0.913" "0.398" "1282.8" "1203.2" "1158.3" "1167.1" "1115.0" "1065.5" "1058.0" "1161.8" "1170.7" "510.0" "" "" "" "" "" "" "" "" "" "" "1137.6" "996.7" "1010.7" "872.8" "929.8" "978.8" "894.2" "960.3" "1073.7" "510.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3011217780081752783" "False" "High" "IsMasterProtein" "O43164" "E3 ubiquitin-protein ligase Praja-2 OS=Homo sapiens OX=9606 GN=PJA2 PE=1 SV=4" "0.000" "False" "40.272" "16" "7" "10" "6" "708" "78.2" "4.39" "37.32" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf13639" "9867" "ENSG00000198961" "PJA2" "A8K6U4; D3DSZ5; O43164; Q68D49; Q8N1G5" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "1" "1.019" "0.991" "1.099" "1.009" "1.020" "0.983" "1.019" "0.934" "0.928" "549.4" "559.6" "544.3" "603.7" "554.6" "560.2" "539.9" "560.0" "512.9" "509.8" "" "" "" "" "" "" "" "" "" "" "487.2" "463.6" "474.9" "451.5" "462.4" "514.6" "456.3" "462.8" "470.4" "509.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.000" "False" "40.196" "8" "9" "12" "9" "1190" "132.9" "5.44" "43.70" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "0" "0.946" "0.912" "0.995" "0.913" "0.883" "0.908" "0.719" "0.878" "4.453" "1520.8" "1438.5" "1386.9" "1513.0" "1389.1" "1342.9" "1381.3" "1092.7" "1335.8" "6772.4" "" "" "" "" "" "" "" "" "" "" "1348.6" "1191.6" "1210.1" "1131.6" "1158.3" "1233.6" "1167.4" "903.2" "1225.1" "6772.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7459111357476572255" "False" "High" "IsMasterProtein" "Q8NFY9" "Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2" "0.000" "False" "40.154" "19" "11" "11" "11" "601" "68.8" "6.29" "34.89" "11" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "84541" "ENSG00000163376" "KBTBD8" "B4DTW6; hsa:84541; Q8NFY9; Q96JI5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.974" "1.057" "1.085" "1.069" "1.074" "1.118" "1.018" "1.059" "1.655" "824.7" "803.0" "871.3" "894.7" "881.6" "885.8" "921.9" "839.7" "873.1" "1364.9" "" "" "" "" "" "" "" "" "" "" "731.3" "665.1" "760.3" "669.1" "735.2" "813.7" "779.1" "694.1" "800.7" "1364.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "40.151" "27" "9" "11" "9" "336" "39.1" "4.81" "40.37" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "0.826" "0.808" "1.000" "0.964" "0.909" "1.450" "1.268" "1.337" "1.815" "963.2" "795.6" "778.2" "963.2" "928.4" "875.4" "1397.1" "1221.3" "1287.9" "1748.3" "" "" "" "" "" "" "" "" "" "" "854.1" "659.0" "679.1" "720.4" "774.2" "804.1" "1180.8" "1009.5" "1181.2" "1748.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5593036104782441701" "False" "High" "IsMasterProtein" "Q8NCF5" "NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1" "0.000" "False" "40.097" "17" "5" "6" "5" "419" "45.8" "6.60" "27.84" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf11976" "84901" "ENSG00000176953" "NFATC2IP" "B7Z4G5; hsa:84901; Q66K34; Q6NVK1; Q8NCF5; Q8NFR2; Q96ST9" "" "16p11.2 distal deletion syndrome" "1" "0" "1.110" "1.052" "1.046" "1.070" "1.032" "1.035" "1.051" "1.035" "1.454" "539.8" "599.4" "568.1" "564.7" "577.8" "556.9" "558.6" "567.1" "558.9" "785.1" "" "" "" "" "" "" "" "" "" "" "478.7" "496.5" "495.7" "422.4" "481.8" "511.6" "472.1" "468.8" "512.6" "785.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546161136539191079" "False" "High" "IsMasterProtein" "O60936" "Nucleolar protein 3 OS=Homo sapiens OX=9606 GN=NOL3 PE=1 SV=2" "0.000" "False" "40.092" "27" "4" "8" "4" "208" "22.6" "4.18" "33.71" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00619" "8996" "ENSG00000140939" "NOL3" "B4DFL0; hsa:8996; O60936; O60937" "" "" "0" "0" "0.947" "0.969" "1.161" "1.071" "1.003" "1.056" "1.012" "1.061" "0.625" "324.6" "307.4" "314.6" "376.8" "347.6" "325.5" "342.7" "328.5" "344.3" "202.9" "" "" "" "" "" "" "" "" "" "" "287.8" "254.6" "274.5" "281.8" "289.9" "299.0" "289.6" "271.5" "315.7" "202.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849598886551382800" "False" "High" "IsMasterProtein" "Q9P2K5" "Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3" "0.000" "False" "40.028" "13" "7" "10" "7" "600" "64.1" "8.75" "36.71" "7" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "50804" "ENSG00000104177" "MYEF2" "A7MCZ9; C9J921; C9K0J4; hsa:50804; Q6NUM5; Q7L388; Q7Z4B7; Q9H922; Q9NUQ1; Q9P2K5" "" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression" "4" "0" "0.963" "0.838" "0.854" "0.846" "0.795" "0.763" "0.514" "0.844" "6.155" "588.6" "566.6" "493.1" "502.9" "498.0" "467.7" "449.2" "302.8" "496.5" "3622.3" "" "" "" "" "" "" "" "" "" "" "521.9" "469.4" "430.2" "376.1" "415.3" "429.7" "379.6" "250.3" "455.4" "3622.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2530096589731876058" "False" "High" "IsMasterProtein" "Q96EK5" "KIF-binding protein OS=Homo sapiens OX=9606 GN=KIFBP PE=1 SV=1" "0.000" "False" "40.000" "14" "7" "10" "6" "621" "71.8" "5.49" "37.70" "7" "cell organization and biogenesis;transport;developmental processes" "cytoskeleton;mitochondrion" "cytoskeletal activity" "Pf12309" "26128" "ENSG00000198954" "KIFBP" "A8K5M8; Q96EK5; Q9BR89; Q9ULE1; Q9Y428" "" "" "0" "0" "1.383" "0.837" "1.223" "0.920" "1.001" "1.099" "0.587" "0.896" "7.317" "148.5" "205.3" "124.3" "181.6" "136.6" "148.6" "163.2" "87.2" "133.0" "1086.6" "" "" "" "" "" "" "" "" "" "" "131.7" "170.1" "108.4" "135.8" "113.9" "136.5" "137.9" "72.1" "122.0" "1086.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "39.978" "27" "10" "27" "10" "248" "27.1" "4.51" "87.67" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "17" "0" "0.979" "0.984" "0.996" "0.991" "0.972" "1.014" "1.029" "1.044" "0.444" "3609.2" "3534.2" "3550.1" "3596.4" "3575.3" "3509.3" "3660.8" "3714.2" "3768.1" "1603.3" "" "" "" "" "" "" "" "" "" "" "3200.5" "2927.6" "3097.7" "2689.6" "2981.3" "3223.6" "3094.0" "3070.0" "3455.8" "1603.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4219913778501772025" "False" "High" "IsMasterProtein" "Q96PE7" "Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1" "0.000" "False" "39.913" "49" "7" "10" "7" "176" "18.7" "9.09" "36.89" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf13669" "84693" "ENSG00000124370" "MCEE" "hsa:84693; Q53TP1; Q8WW63; Q96PE7" "Propionyl-CoA catabolism" "Vitamin B12 metabolism" "2" "0" "1.066" "1.042" "0.995" "1.013" "1.143" "1.060" "1.094" "1.070" "0.391" "838.9" "894.3" "874.1" "834.4" "849.7" "959.0" "889.5" "917.5" "897.6" "327.9" "" "" "" "" "" "" "" "" "" "" "743.9" "740.8" "762.7" "624.1" "708.5" "880.9" "751.8" "758.4" "823.2" "327.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1754940364025586367" "False" "High" "IsMasterProtein" "Q9Y6R0" "Numb-like protein OS=Homo sapiens OX=9606 GN=NUMBL PE=1 SV=1" "0.000" "False" "39.902" "15" "9" "10" "6" "609" "64.9" "8.85" "36.61" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "" "Pf00640, Pf06311" "9253" "ENSG00000105245" "NUMBL" "hsa:9253; Q7Z4J9; Q9Y6R0" "" "Notch signaling; Neurogenesis regulation in the olfactory epithelium; Notch signaling pathway" "3" "0" "0.982" "1.019" "0.963" "1.008" "0.975" "1.010" "1.001" "0.981" "0.980" "442.2" "434.1" "450.6" "425.7" "445.7" "431.2" "446.7" "442.5" "433.7" "433.2" "" "" "" "" "" "" "" "" "" "" "392.1" "359.6" "393.2" "318.3" "371.6" "396.1" "377.5" "365.8" "397.8" "433.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "39.860" "29" "5" "16" "5" "198" "21.3" "8.87" "57.19" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "0.948" "1.015" "0.971" "0.911" "0.944" "0.914" "0.933" "1.007" "0.444" "1362.9" "1292.1" "1383.9" "1323.5" "1241.5" "1286.9" "1245.3" "1272.2" "1372.5" "604.7" "" "" "" "" "" "" "" "" "" "" "1208.6" "1070.3" "1207.5" "989.8" "1035.2" "1182.1" "1052.5" "1051.6" "1258.8" "604.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "39.822" "21" "6" "12" "6" "326" "34.8" "9.09" "46.32" "6" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "1.014" "0.956" "1.012" "0.987" "0.991" "0.932" "0.960" "0.922" "0.684" "1762.1" "1786.6" "1684.7" "1783.9" "1738.7" "1747.0" "1642.9" "1691.5" "1625.0" "1206.0" "" "" "" "" "" "" "" "" "" "" "1562.6" "1479.9" "1470.0" "1334.1" "1449.8" "1604.8" "1388.5" "1398.1" "1490.3" "1206.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-569299239056590327" "False" "High" "IsMasterProtein" "Q9Y4F9" "Rho family-interacting cell polarization regulator 2 OS=Homo sapiens OX=9606 GN=RIPOR2 PE=1 SV=4" "0.000" "False" "39.806" "7" "7" "9" "7" "1068" "118.4" "5.41" "34.61" "7" "cell adhesion;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf15903" "9750" "ENSG00000111913" "RIPOR2" "A6NHP2; hsa:9750; Q13529; Q5VV37; Q5VV38; Q9BQ28; Q9Y4F9" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "1.015" "1.040" "1.006" "1.149" "1.040" "0.834" "0.835" "0.925" "0.843" "594.8" "603.6" "618.4" "598.5" "683.3" "618.8" "496.1" "496.7" "550.3" "501.2" "" "" "" "" "" "" "" "" "" "" "527.4" "500.0" "539.6" "447.6" "569.8" "568.4" "419.3" "410.6" "504.7" "501.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8347450561102329946" "False" "High" "IsMasterProtein" "Q96BZ4" "5'-3' exonuclease PLD4 OS=Homo sapiens OX=9606 GN=PLD4 PE=1 SV=2" "0.000" "False" "39.773" "20" "9" "20" "8" "506" "55.6" "8.35" "68.42" "9" "DNA metabolism;stress response;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13918" "122618" "ENSG00000166428" "PLD4" "hsa:122618; Q6UWD2; Q96BZ4" "Role of phospholipids in phagocytosis; Synthesis of PG; Synthesis of IP3 and IP4 in the cytosol" "" "3" "1" "1.091" "1.035" "1.110" "1.132" "1.053" "1.058" "0.992" "0.936" "0.579" "1586.3" "1730.4" "1641.3" "1760.7" "1795.7" "1670.3" "1678.9" "1574.0" "1485.2" "918.2" "" "" "" "" "" "" "" "" "" "" "1406.7" "1433.4" "1432.1" "1316.8" "1497.3" "1534.4" "1418.9" "1301.0" "1362.1" "918.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "39.711" "9" "12" "12" "9" "1123" "128.6" "6.32" "39.83" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "2" "1.037" "0.908" "1.011" "0.927" "0.877" "0.900" "0.847" "0.873" "1.244" "1341.4" "1390.7" "1217.4" "1356.5" "1243.1" "1176.2" "1207.6" "1136.3" "1170.7" "1668.4" "" "" "" "" "" "" "" "" "" "" "1189.6" "1152.0" "1062.2" "1014.5" "1036.6" "1080.5" "1020.6" "939.2" "1073.7" "1668.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.000" "False" "39.709" "28" "8" "8" "8" "336" "37.9" "7.12" "30.95" "8" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "0.922" "0.827" "0.909" "0.816" "0.677" "0.608" "0.462" "0.617" "4.441" "347.4" "320.4" "287.5" "315.9" "283.5" "235.4" "211.1" "160.7" "214.4" "1543.1" "" "" "" "" "" "" "" "" "" "" "308.1" "265.4" "250.8" "236.2" "236.4" "216.2" "178.4" "132.8" "196.7" "1543.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "39.629" "71" "6" "11" "6" "96" "11.2" "8.88" "43.03" "6" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "0.940" "0.955" "0.979" "0.940" "1.026" "1.082" "1.123" "1.046" "0.583" "2372.8" "2229.8" "2265.7" "2322.6" "2230.2" "2434.3" "2567.5" "2665.2" "2481.3" "1384.4" "" "" "" "" "" "" "" "" "" "" "2104.1" "1847.0" "1976.9" "1737.0" "1859.7" "2236.2" "2170.0" "2203.0" "2275.7" "1384.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5262953241339830264" "False" "High" "IsMasterProtein" "Q8WUH6" "Transmembrane protein 263 OS=Homo sapiens OX=9606 GN=TMEM263 PE=1 SV=1" "0.000" "False" "39.562" "66" "5" "6" "5" "116" "11.7" "9.32" "27.30" "5" "" "other membranes" "" "Pf15475" "90488" "ENSG00000151135" "TMEM263" "B3KMN9; hsa:90488; Q8WUH6" "" "" "0" "0" "1.067" "1.139" "1.000" "1.056" "0.894" "1.030" "0.945" "1.105" "1.076" "628.3" "670.6" "715.6" "628.2" "663.6" "562.0" "647.5" "594.0" "694.2" "676.4" "" "" "" "" "" "" "" "" "" "" "557.2" "555.5" "624.4" "469.8" "553.4" "516.2" "547.2" "491.0" "636.7" "676.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "39.555" "21" "9" "18" "9" "409" "47.2" "6.32" "51.94" "9" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "Histidine catabolism" "" "1" "0" "0.976" "0.952" "0.948" "0.982" "1.006" "0.961" "0.943" "0.949" "0.805" "2004.4" "1956.4" "1908.6" "1899.6" "1968.0" "2016.9" "1925.6" "1891.2" "1902.8" "1614.3" "" "" "" "" "" "" "" "" "" "" "1777.5" "1620.6" "1665.3" "1420.7" "1641.0" "1852.8" "1627.4" "1563.2" "1745.1" "1614.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "39.535" "26" "13" "25" "13" "456" "50.4" "8.16" "71.82" "13" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "Potential therapeutics for SARS; Regulation of signaling by CBL; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "0.913" "0.944" "0.833" "0.908" "0.975" "0.773" "0.802" "0.792" "0.624" "4094.2" "3739.1" "3866.5" "3411.6" "3717.7" "3990.0" "3163.6" "3283.0" "3243.7" "2556.3" "" "" "" "" "" "" "" "" "" "" "3630.6" "3097.3" "3373.7" "2551.5" "3100.0" "3665.3" "2673.8" "2713.7" "2975.0" "2556.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086525266732812690" "False" "High" "IsMasterProtein" "Q9Y5P4" "Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT1 PE=1 SV=1" "0.000" "False" "39.532" "11" "7" "10" "7" "624" "70.8" "5.48" "39.04" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus" "transporter activity;kinase activity;other molecular function" "Pf00169, Pf01852" "10087" "ENSG00000113163" "CERT1" "A8K7S2; B3KUB7; hsa:10087; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; Q9Y5P4" "" "Sphingolipid pathway" "1" "0" "1.039" "0.946" "0.868" "0.914" "0.872" "1.049" "0.648" "1.125" "8.682" "626.1" "650.7" "592.2" "543.7" "572.3" "546.1" "656.9" "405.6" "704.1" "5435.5" "" "" "" "" "" "" "" "" "" "" "555.2" "539.0" "516.8" "406.6" "477.3" "501.7" "555.2" "335.3" "645.7" "5435.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4123477520333659496" "False" "High" "IsMasterProtein" "Q7Z4G4" "tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1" "0.000" "False" "39.520" "18" "8" "11" "8" "463" "53.4" "7.78" "38.48" "8" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01170" "60487" "ENSG00000066651" "TRMT11" "E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.015" "1.081" "0.960" "1.057" "1.063" "1.029" "1.068" "1.064" "0.521" "1320.3" "1340.6" "1427.0" "1267.6" "1396.0" "1403.3" "1358.9" "1409.7" "1405.0" "687.3" "" "" "" "" "" "" "" "" "" "" "1170.8" "1110.5" "1245.1" "948.0" "1164.1" "1289.1" "1148.5" "1165.2" "1288.6" "687.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335740267375587213" "False" "High" "IsMasterProtein" "P09132" "Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3" "0.000" "False" "39.517" "28" "3" "5" "3" "144" "16.1" "9.85" "21.13" "3" "cell organization and biogenesis;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01922" "6728" "ENSG00000153037" "SRP19" "B2R4E9; D6RCQ5; hsa:6728; P09132; Q05D77; Q96FG6" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "1.073" "1.002" "1.078" "1.058" "1.018" "1.017" "0.946" "1.037" "1.460" "498.8" "535.3" "499.9" "537.8" "527.5" "507.7" "507.2" "472.0" "517.2" "728.2" "" "" "" "" "" "" "" "" "" "" "442.4" "443.4" "436.2" "402.2" "439.9" "466.4" "428.7" "390.1" "474.4" "728.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-81494833362564834" "False" "High" "IsMasterProtein" "Q8WVJ2" "NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1" "0.000" "False" "39.456" "36" "4" "7" "4" "157" "17.7" "5.07" "37.14" "4" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04969" "134492" "ENSG00000170584" "NUDCD2" "B2R4V0; hsa:134492; Q8WVJ2" "" "" "0" "0" "1.099" "0.940" "1.035" "1.018" "0.989" "1.125" "0.578" "0.911" "6.948" "395.9" "435.0" "372.0" "409.9" "402.9" "391.4" "445.5" "228.9" "360.5" "2750.7" "" "" "" "" "" "" "" "" "" "" "351.1" "360.3" "324.6" "306.5" "336.0" "359.5" "376.5" "189.2" "330.6" "2750.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "39.445" "21" "6" "7" "6" "277" "31.0" "5.83" "30.84" "6" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "Glycosphingolipid catabolism; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "" "5" "0" "1.000" "0.886" "1.010" "1.013" "1.017" "1.108" "0.978" "1.192" "1.335" "1012.5" "1012.4" "896.9" "1022.4" "1025.4" "1029.2" "1121.4" "990.4" "1207.3" "1351.7" "" "" "" "" "" "" "" "" "" "" "897.9" "838.6" "782.6" "764.7" "855.1" "945.5" "947.8" "818.6" "1107.2" "1351.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "39.323" "20" "7" "10" "7" "420" "46.3" "7.21" "36.20" "7" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "Synthesis of GDP-mannose" "N-glycan biosynthesis" "2" "0" "1.067" "0.991" "1.136" "1.070" "1.051" "1.106" "1.082" "1.026" "0.665" "615.0" "656.2" "609.6" "698.6" "658.2" "646.5" "680.0" "665.3" "630.9" "409.0" "" "" "" "" "" "" "" "" "" "" "545.4" "543.5" "531.9" "522.4" "548.8" "593.9" "574.7" "549.9" "578.7" "409.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.000" "False" "39.295" "11" "6" "7" "6" "557" "65.6" "6.64" "29.83" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "mRNA Splicing - Major Pathway" "" "1" "0" "0.987" "0.963" "0.990" "0.943" "0.952" "0.892" "0.885" "0.994" "2.476" "868.5" "857.5" "836.3" "860.2" "818.7" "826.9" "774.9" "768.9" "863.5" "2150.6" "" "" "" "" "" "" "" "" "" "" "770.1" "710.3" "729.7" "643.3" "682.7" "759.6" "654.9" "635.6" "791.9" "2150.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "39.229" "20" "11" "12" "11" "552" "60.4" "6.99" "44.04" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Ub-specific processing proteases; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "53" "0" "1.032" "1.065" "1.016" "0.983" "1.022" "0.946" "1.010" "0.932" "0.905" "1296.7" "1337.7" "1380.8" "1316.9" "1274.6" "1325.1" "1227.2" "1309.1" "1208.3" "1173.1" "" "" "" "" "" "" "" "" "" "" "1149.9" "1108.1" "1204.8" "984.8" "1062.9" "1217.3" "1037.2" "1082.0" "1108.2" "1173.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2840679928359396214" "False" "High" "IsMasterProtein" "Q6P1N0" "Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1" "0.000" "False" "39.202" "11" "10" "10" "10" "951" "104.0" "8.09" "35.71" "10" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "54862" "ENSG00000132024; ENSG00000288293" "CC2D1A" "hsa:54862; Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "0" "1.082" "1.036" "1.024" "1.076" "0.990" "1.065" "0.919" "1.109" "3.826" "735.2" "795.2" "761.8" "752.8" "791.0" "727.8" "783.3" "675.7" "815.4" "2812.7" "" "" "" "" "" "" "" "" "" "" "652.0" "658.7" "664.7" "563.0" "659.6" "668.5" "662.0" "558.5" "747.8" "2812.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.000" "False" "39.088" "12" "7" "8" "7" "659" "74.4" "6.74" "30.99" "7" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Genes related to primary cilium development (based on CRISPR)" "8" "0" "1.151" "0.946" "1.183" "1.113" "1.088" "1.171" "1.090" "0.909" "0.799" "592.5" "682.0" "560.4" "700.9" "659.7" "644.6" "694.0" "645.5" "538.6" "473.4" "" "" "" "" "" "" "" "" "" "" "525.4" "564.9" "489.0" "524.2" "550.1" "592.1" "586.5" "533.6" "493.9" "473.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573185288358324905" "False" "High" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "0.000" "False" "39.061" "16" "6" "10" "6" "392" "43.1" "6.29" "38.54" "6" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Primary ovarian insufficiency" "3" "0" "0.967" "0.924" "0.890" "0.871" "0.856" "0.933" "0.950" "0.998" "0.518" "1457.3" "1409.1" "1346.0" "1297.1" "1269.5" "1247.6" "1360.0" "1384.5" "1454.1" "755.5" "" "" "" "" "" "" "" "" "" "" "1292.3" "1167.3" "1174.5" "970.1" "1058.6" "1146.1" "1149.4" "1144.4" "1333.6" "755.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "38.999" "45" "6" "11" "5" "191" "21.3" "8.12" "43.96" "6" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; RHO GTPases activate KTN1" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "8" "0" "1.051" "1.023" "1.026" "1.032" "1.006" "1.046" "0.989" "1.080" "1.146" "703.1" "739.1" "719.4" "721.4" "725.8" "707.0" "735.6" "695.4" "759.2" "805.6" "" "" "" "" "" "" "" "" "" "" "623.5" "612.3" "627.7" "539.5" "605.2" "649.4" "621.7" "574.8" "696.3" "805.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335320329939268762" "False" "High" "IsMasterProtein" "Q9UBR2" "Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1" "0.000" "False" "38.935" "27" "8" "13" "8" "303" "33.8" "7.11" "47.05" "8" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112" "1522" "ENSG00000101160" "CTSZ" "B2RC40; hsa:1522; O75331; Q9UBR2; Q9UQV5; Q9UQV6" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Lysosome Vesicle Biogenesis; COPII-mediated vesicle transport; Cargo concentration in the ER" "" "5" "0" "0.961" "1.024" "1.013" "0.935" "1.013" "0.883" "1.025" "0.967" "0.509" "1341.8" "1288.9" "1374.1" "1359.2" "1255.2" "1358.9" "1185.3" "1375.9" "1298.1" "682.4" "" "" "" "" "" "" "" "" "" "" "1189.9" "1067.7" "1199.0" "1016.5" "1046.7" "1248.3" "1001.8" "1137.3" "1190.6" "682.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6376451565471680516" "False" "High" "IsMasterProtein" "Q6P4I2" "WD repeat-containing protein 73 OS=Homo sapiens OX=9606 GN=WDR73 PE=1 SV=1" "0.000" "False" "38.930" "22" "8" "11" "8" "378" "41.7" "5.78" "40.24" "8" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "" "" "84942" "ENSG00000177082; ENSG00000291629" "WDR73" "hsa:84942; Q6P4I2; Q96JZ1; Q9P0B7" "" "Nephrotic syndrome; 15q25 copy number variation" "2" "0" "0.974" "0.991" "1.028" "1.005" "1.060" "1.052" "1.130" "0.953" "0.678" "692.4" "674.3" "686.3" "712.0" "695.6" "734.3" "728.7" "782.5" "660.1" "469.5" "" "" "" "" "" "" "" "" "" "" "614.0" "558.6" "598.8" "532.5" "580.0" "674.6" "615.9" "646.8" "605.4" "469.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2241526083572897290" "False" "High" "IsMasterProtein" "Q9ULX6" "A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4" "0.000" "False" "38.901" "16" "8" "9" "8" "646" "71.6" "5.05" "35.11" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "26993" "ENSG00000011243" "AKAP8L" "B4DJ74; B5BU90; hsa:26993; O94792; Q96J58; Q9NRQ0; Q9UGM0; Q9ULX6" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "1.066" "0.986" "1.108" "1.050" "1.035" "0.998" "0.557" "1.008" "7.785" "695.8" "741.7" "686.4" "770.8" "730.8" "719.9" "694.7" "387.3" "701.6" "5417.0" "" "" "" "" "" "" "" "" "" "" "617.1" "614.4" "598.9" "576.5" "609.4" "661.4" "587.2" "320.1" "643.5" "5417.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1386453636298102119" "False" "High" "IsMasterProtein" "Q8NDH3" "Probable aminopeptidase NPEPL1 OS=Homo sapiens OX=9606 GN=NPEPL1 PE=1 SV=3" "0.000" "False" "38.861" "12" "7" "10" "7" "523" "55.8" "6.87" "38.46" "7" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf18295" "79716" "ENSG00000215440" "NPEPL1" "A6NGZ0; B4DMW7; B7ZBN0; E9PN47; G5EA34; hsa:79716; Q53G37; Q5W083; Q8NDH3; Q8TF28; Q8WUI2; Q9H1T6; Q9HAI5" "" "" "0" "0" "1.004" "1.022" "0.926" "1.006" "1.068" "0.990" "0.963" "1.005" "0.525" "825.9" "829.3" "843.8" "764.5" "830.9" "881.9" "817.7" "795.3" "830.2" "433.7" "" "" "" "" "" "" "" "" "" "" "732.4" "686.9" "736.3" "571.8" "692.8" "810.1" "691.1" "657.4" "761.4" "433.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "38.836" "23" "4" "8" "4" "192" "21.9" "9.95" "34.66" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "1.088" "1.266" "0.915" "1.005" "1.023" "1.024" "1.030" "1.283" "0.735" "624.6" "679.4" "790.9" "571.7" "627.4" "638.9" "639.5" "643.2" "801.2" "459.2" "" "" "" "" "" "" "" "" "" "" "553.9" "562.7" "690.1" "427.6" "523.2" "586.9" "540.5" "531.6" "734.9" "459.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "38.765" "9" "10" "12" "10" "1052" "121.8" "8.09" "39.11" "10" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "10q11.21q11.23 copy number variation syndrome" "5" "0" "0.964" "0.947" "0.955" "0.841" "1.020" "0.999" "0.888" "0.848" "4.611" "313.5" "302.1" "297.0" "299.4" "263.8" "319.8" "313.2" "278.4" "265.8" "1445.7" "" "" "" "" "" "" "" "" "" "" "278.0" "250.2" "259.1" "223.9" "219.9" "293.8" "264.7" "230.1" "243.8" "1445.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6030770174415932169" "False" "High" "IsMasterProtein" "P52294" "Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3" "0.000" "False" "38.738" "15" "9" "12" "5" "538" "60.2" "5.01" "41.60" "9" "cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3836" "ENSG00000114030" "KPNA1" "D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56" "Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Apoptosis induced DNA fragmentation; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production" "Ebola virus infection in host" "10" "3" "1.061" "0.944" "1.038" "0.945" "0.960" "0.998" "0.858" "0.953" "3.010" "553.3" "586.8" "522.4" "574.5" "522.6" "531.1" "552.0" "474.8" "527.1" "1665.1" "" "" "" "" "" "" "" "" "" "" "490.6" "486.1" "455.8" "429.7" "435.8" "487.8" "466.5" "392.4" "483.4" "1665.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "38.683" "8" "11" "12" "11" "1362" "152.1" "9.19" "40.44" "11" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "Potential therapeutics for SARS" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "0" "1.083" "0.926" "1.000" "0.882" "0.773" "0.749" "0.687" "0.880" "3.487" "417.5" "452.0" "386.6" "417.5" "368.2" "322.5" "312.5" "286.7" "367.4" "1455.8" "" "" "" "" "" "" "" "" "" "" "370.2" "374.4" "337.3" "312.2" "307.0" "296.3" "264.1" "237.0" "336.9" "1455.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "High" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.000" "False" "38.605" "8" "15" "15" "15" "1907" "213.6" "4.84" "41.80" "15" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Cargo concentration in the ER; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Type I collagen synthesis in the context of osteogenesis imperfecta" "4" "0" "0.982" "0.947" "0.950" "0.913" "0.928" "0.971" "0.999" "1.010" "0.617" "1402.2" "1376.3" "1328.3" "1332.4" "1279.5" "1301.2" "1361.1" "1400.3" "1416.5" "865.5" "" "" "" "" "" "" "" "" "" "" "1243.5" "1140.1" "1159.0" "996.5" "1067.0" "1195.3" "1150.3" "1157.4" "1299.2" "865.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.000" "False" "38.546" "55" "6" "12" "6" "110" "11.5" "6.73" "49.62" "6" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "0.992" "0.912" "1.059" "1.031" "0.931" "1.107" "1.001" "0.970" "0.673" "475.7" "472.1" "433.6" "503.9" "490.5" "442.6" "526.5" "476.0" "461.4" "320.3" "" "" "" "" "" "" "" "" "" "" "421.8" "391.0" "378.3" "376.9" "409.1" "406.6" "444.9" "393.4" "423.2" "320.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "High" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.000" "False" "38.535" "17" "9" "10" "9" "501" "54.1" "6.24" "35.52" "9" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "0.987" "0.946" "1.016" "0.999" "0.863" "0.894" "0.341" "0.868" "11.917" "384.9" "380.0" "364.0" "391.0" "384.7" "332.1" "344.1" "131.4" "334.1" "4587.2" "" "" "" "" "" "" "" "" "" "" "341.3" "314.8" "317.6" "292.4" "320.8" "305.0" "290.8" "108.6" "306.4" "4587.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3427861429656696180" "False" "High" "IsMasterProtein" "O95197" "Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2" "0.000" "False" "38.442" "11" "10" "11" "10" "1032" "112.5" "4.96" "38.98" "10" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf02453" "10313" "ENSG00000133318" "RTN3" "B3KQS2; B7Z308; B7Z4M0; F5H774; hsa:10313; O95197; Q147U9; Q496K2; Q53GN3; Q59EP0; Q5UEP2; Q6T930; Q7RTM7; Q7RTM8; Q7RTN3" "Synaptic adhesion-like molecules" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "3" "0" "1.020" "1.015" "1.026" "1.088" "1.076" "1.077" "1.078" "1.112" "0.615" "289.7" "295.6" "294.2" "297.3" "315.3" "311.6" "312.0" "312.4" "322.0" "178.1" "" "" "" "" "" "" "" "" "" "" "256.9" "244.8" "256.7" "222.4" "262.9" "286.3" "263.7" "258.3" "295.4" "178.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.000" "False" "38.410" "19" "12" "18" "12" "516" "56.9" "7.36" "54.50" "12" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "COPI-mediated anterograde transport; CDC42 GTPase cycle; RHOG GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic" "Ciliary landscape" "5" "0" "0.940" "0.930" "0.827" "0.837" "0.883" "0.865" "0.889" "0.956" "0.940" "1495.4" "1405.7" "1390.9" "1236.3" "1252.0" "1320.3" "1293.2" "1329.9" "1429.9" "1405.6" "" "" "" "" "" "" "" "" "" "" "1326.1" "1164.4" "1213.6" "924.6" "1044.0" "1212.8" "1092.9" "1099.3" "1311.4" "1405.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "38.398" "25" "3" "14" "3" "159" "17.4" "9.67" "53.38" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "mRNA Splicing - Major Pathway" "" "1" "0" "0.909" "0.992" "0.944" "0.947" "0.953" "0.996" "1.009" "0.922" "0.460" "1454.0" "1322.1" "1442.7" "1373.0" "1376.5" "1385.5" "1448.1" "1466.5" "1340.2" "668.6" "" "" "" "" "" "" "" "" "" "" "1289.4" "1095.1" "1258.9" "1026.9" "1147.8" "1272.8" "1223.9" "1212.2" "1229.1" "668.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5167676998188788346" "False" "High" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "0.000" "False" "38.356" "8" "8" "12" "8" "1170" "129.9" "6.93" "40.44" "8" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "0.951" "0.942" "0.998" "0.883" "0.920" "0.877" "0.879" "0.933" "0.901" "720.4" "685.2" "678.6" "718.7" "636.0" "662.6" "631.9" "633.1" "672.5" "649.2" "" "" "" "" "" "" "" "" "" "" "638.8" "567.5" "592.1" "537.5" "530.4" "608.7" "534.1" "523.3" "616.7" "649.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.000" "False" "38.328" "62" "5" "9" "5" "86" "10.2" "7.05" "36.26" "5" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "7" "0" "1.027" "1.009" "1.067" "1.020" "1.052" "1.075" "1.102" "1.049" "0.810" "1264.4" "1298.4" "1275.5" "1349.5" "1289.8" "1329.6" "1359.4" "1393.5" "1326.5" "1024.6" "" "" "" "" "" "" "" "" "" "" "1121.3" "1075.6" "1113.0" "1009.3" "1075.5" "1221.4" "1148.9" "1151.9" "1216.6" "1024.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4927987348987010712" "False" "High" "IsMasterProtein" "P35790" "Choline kinase alpha OS=Homo sapiens OX=9606 GN=CHKA PE=1 SV=3" "0.000" "False" "38.325" "22" "11" "13" "11" "457" "52.2" "6.55" "42.37" "11" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1119" "ENSG00000110721" "CHKA" "hsa:1119; P35790; Q8NE29" "Synthesis of PC; Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis" "6" "0" "1.089" "1.022" "1.146" "1.057" "1.086" "1.081" "0.970" "0.903" "0.955" "694.4" "755.8" "709.7" "795.4" "733.9" "754.0" "750.7" "673.8" "627.1" "663.4" "" "" "" "" "" "" "" "" "" "" "615.7" "626.1" "619.3" "594.9" "612.0" "692.7" "634.5" "556.9" "575.2" "663.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8206347650273111002" "False" "High" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.000" "False" "38.305" "51" "6" "9" "6" "122" "13.3" "8.46" "36.33" "6" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "0.871" "0.783" "0.752" "0.672" "0.673" "0.648" "0.775" "0.771" "0.453" "1788.0" "1557.0" "1400.4" "1344.4" "1201.2" "1203.3" "1159.4" "1385.6" "1379.2" "810.5" "" "" "" "" "" "" "" "" "" "" "1585.6" "1289.7" "1222.0" "1005.5" "1001.6" "1105.4" "979.9" "1145.3" "1264.9" "810.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.000" "False" "38.288" "15" "10" "12" "10" "699" "78.1" "8.29" "39.27" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "Nanoparticle triggered autophagic cell death; Autophagy" "6" "0" "1.001" "0.932" "0.934" "0.944" "0.976" "0.913" "0.894" "1.029" "0.980" "599.6" "600.1" "558.7" "560.0" "565.8" "585.4" "547.2" "535.9" "617.2" "587.8" "" "" "" "" "" "" "" "" "" "" "531.7" "497.1" "487.5" "418.8" "471.8" "537.8" "462.5" "442.9" "566.0" "587.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "38.227" "44" "7" "15" "7" "165" "18.9" "10.15" "49.35" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.958" "0.940" "1.019" "0.950" "0.931" "0.889" "0.884" "0.940" "1.497" "809.3" "775.7" "761.1" "824.4" "768.7" "753.3" "719.3" "715.5" "760.9" "1211.3" "" "" "" "" "" "" "" "" "" "" "717.7" "642.5" "664.1" "616.6" "641.0" "692.0" "607.9" "591.5" "697.9" "1211.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5416177737731563011" "False" "High" "IsMasterProtein" "Q14457" "Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2" "0.000" "False" "38.209" "19" "9" "11" "9" "450" "51.9" "4.89" "40.70" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04111, Pf15285, Pf17675" "8678" "ENSG00000126581" "BECN1" "B2R6N7; hsa:8678; O75595; Q14457; Q9UNA8" "Macroautophagy; RSV-host interactions; Ub-specific processing proteases; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "18" "0" "1.045" "0.977" "0.916" "0.944" "0.983" "0.949" "0.952" "0.978" "1.254" "557.6" "583.0" "544.7" "510.7" "526.6" "548.0" "529.2" "531.0" "545.1" "699.4" "" "" "" "" "" "" "" "" "" "" "494.5" "482.9" "475.3" "381.9" "439.1" "503.4" "447.2" "438.9" "499.9" "699.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4068487784358334043" "False" "High" "IsMasterProtein" "Q8TDX7" "Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1" "0.000" "False" "38.193" "26" "6" "7" "6" "302" "34.5" "8.25" "29.56" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "140609" "ENSG00000151414" "NEK7" "A6NGT8; hsa:140609; Q8TDX7" "Nuclear Pore Complex (NPC) Disassembly; EML4 and NUDC in mitotic spindle formation; Activation of NIMA Kinases NEK9, NEK6, NEK7" "Ciliary landscape; EPAC1 and PKA reduction of retinal inflammation" "5" "0" "1.071" "1.139" "1.025" "1.110" "1.141" "1.269" "1.153" "1.187" "1.669" "465.8" "498.6" "530.4" "477.5" "517.0" "531.3" "591.0" "536.8" "553.0" "777.2" "" "" "" "" "" "" "" "" "" "" "413.0" "413.0" "462.8" "357.1" "431.1" "488.0" "499.5" "443.7" "507.2" "777.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "38.192" "32" "4" "11" "4" "157" "16.6" "6.79" "44.17" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "2" "0" "1.094" "1.107" "0.985" "0.986" "1.094" "1.055" "1.053" "1.065" "0.661" "544.2" "595.4" "602.3" "535.8" "536.9" "595.3" "574.3" "573.1" "579.5" "359.8" "" "" "" "" "" "" "" "" "" "" "482.6" "493.2" "525.6" "400.7" "447.7" "546.9" "485.3" "473.7" "531.5" "359.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.000" "False" "38.147" "10" "5" "8" "5" "480" "54.4" "6.61" "33.95" "5" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "MHC class II antigen presentation; Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "Ciliary landscape" "6" "0" "0.968" "1.096" "0.912" "1.038" "1.215" "0.977" "1.092" "1.060" "0.543" "2157.2" "2087.6" "2365.0" "1966.9" "2239.3" "2620.5" "2108.1" "2356.4" "2285.6" "1170.7" "" "" "" "" "" "" "" "" "" "" "1912.9" "1729.3" "2063.6" "1471.0" "1867.3" "2407.2" "1781.7" "1947.7" "2096.2" "1170.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4713550819086734085" "False" "High" "IsMasterProtein" "Q96AT9" "Ribulose-phosphate 3-epimerase OS=Homo sapiens OX=9606 GN=RPE PE=1 SV=1" "0.000" "False" "38.136" "19" "4" "11" "4" "228" "24.9" "5.58" "46.44" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "6120" "ENSG00000197713" "RPE" "A8K4S0; B4E016; C9JPQ7; hsa:6120; O43767; Q53TV9; Q8N215; Q96AT9; Q96N34; Q9BSB5" "Pentose phosphate pathway" "Pentose phosphate metabolism; Pentose phosphate pathway in senescent cells" "3" "0" "1.019" "0.950" "1.081" "1.075" "1.070" "1.058" "1.065" "0.988" "0.490" "969.8" "988.5" "920.9" "1048.3" "1042.9" "1037.4" "1026.1" "1032.5" "958.5" "475.4" "" "" "" "" "" "" "" "" "" "" "860.0" "818.9" "803.6" "784.0" "869.6" "953.0" "867.3" "853.5" "879.1" "475.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2208639490373230766" "False" "High" "IsMasterProtein" "Q92882" "Osteoclast-stimulating factor 1 OS=Homo sapiens OX=9606 GN=OSTF1 PE=1 SV=2" "0.000" "False" "38.065" "31" "5" "6" "5" "214" "23.8" "5.68" "25.45" "5" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00018, Pf12796" "26578" "ENSG00000134996" "OSTF1" "hsa:26578; Q5W126; Q92882; Q96IJ4" "Neutrophil degranulation" "" "1" "0" "1.076" "1.031" "0.979" "1.058" "1.098" "0.976" "0.992" "1.105" "2.225" "450.4" "484.7" "464.5" "441.1" "476.6" "494.5" "439.7" "446.7" "497.8" "1002.1" "" "" "" "" "" "" "" "" "" "" "399.4" "401.5" "405.3" "329.9" "397.4" "454.3" "371.6" "369.2" "456.6" "1002.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "High" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.000" "False" "38.064" "6" "6" "7" "6" "1273" "145.1" "7.25" "26.67" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by PPARalpha; Regulation of MECP2 expression and activity; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "19" "0" "1.086" "1.030" "1.084" "1.029" "0.989" "1.053" "0.782" "0.936" "3.054" "354.5" "385.0" "365.3" "384.2" "364.6" "350.7" "373.1" "277.3" "331.7" "1082.7" "" "" "" "" "" "" "" "" "" "" "314.3" "318.9" "318.7" "287.3" "304.0" "322.2" "315.3" "229.2" "304.2" "1082.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.000" "False" "38.031" "64" "8" "15" "8" "130" "14.8" "10.13" "46.39" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.943" "0.916" "1.011" "0.971" "0.720" "0.865" "0.891" "0.987" "1.784" "1103.1" "1040.4" "1011.0" "1114.8" "1071.3" "794.6" "954.1" "983.2" "1088.5" "1968.3" "" "" "" "" "" "" "" "" "" "" "978.2" "861.8" "882.1" "833.7" "893.3" "729.9" "806.4" "812.7" "998.3" "1968.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "38.021" "66" "5" "11" "5" "86" "10.1" "6.52" "46.32" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "0" "1.017" "0.960" "0.950" "0.942" "0.943" "0.933" "0.974" "0.908" "0.752" "976.5" "992.8" "937.9" "927.8" "919.4" "921.3" "910.7" "951.1" "886.9" "734.0" "" "" "" "" "" "" "" "" "" "" "865.9" "822.4" "818.4" "693.8" "766.7" "846.3" "769.7" "786.2" "813.4" "734.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8567537084386512250" "False" "High" "IsMasterProtein" "P20933" "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2" "0.000" "False" "38.002" "21" "7" "10" "7" "346" "37.2" "6.28" "34.56" "7" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01112" "175" "ENSG00000038002" "AGA" "B2R7H2; D3DP47; hsa:175; P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8" "Neutrophil degranulation" "" "1" "0" "0.965" "0.932" "0.936" "0.880" "0.832" "0.832" "0.919" "0.917" "0.463" "1441.5" "1391.5" "1343.1" "1348.5" "1269.2" "1199.5" "1199.2" "1324.5" "1321.3" "667.1" "" "" "" "" "" "" "" "" "" "" "1278.3" "1152.7" "1171.9" "1008.5" "1058.3" "1101.9" "1013.5" "1094.8" "1211.8" "667.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.000" "False" "37.918" "18" "10" "10" "10" "726" "80.6" "8.78" "39.83" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "17" "0" "0.966" "1.082" "1.059" "1.019" "0.998" "1.011" "1.012" "1.029" "1.095" "392.8" "379.5" "425.0" "416.0" "400.0" "391.9" "397.3" "397.6" "404.3" "430.3" "" "" "" "" "" "" "" "" "" "" "348.3" "314.4" "370.8" "311.1" "333.6" "360.0" "335.8" "328.6" "370.8" "430.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984641138409737976" "False" "High" "IsMasterProtein" "Q9BXK5" "Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1" "0.000" "False" "37.908" "17" "5" "6" "5" "485" "52.7" "4.44" "30.30" "5" "other biological processes" "other membranes;mitochondrion;nucleus" "enzyme regulator activity" "Pf00452" "23786" "ENSG00000099968" "BCL2L13" "B3KPE7; hsa:23786; Q96B37; Q96IB7; Q9BXK5; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3" "" "Regulation of apoptosis by parathyroid hormone-related protein; TAR syndrome" "2" "0" "1.062" "1.066" "1.020" "1.075" "1.038" "1.103" "1.072" "1.126" "0.537" "807.1" "856.7" "860.0" "823.3" "867.9" "838.1" "890.1" "865.5" "908.6" "433.5" "" "" "" "" "" "" "" "" "" "" "715.7" "709.7" "750.4" "615.7" "723.7" "769.9" "752.3" "715.4" "833.3" "433.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8338185896590092974" "False" "High" "IsMasterProtein" "Q9H0B6" "Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1" "0.000" "False" "37.892" "12" "7" "9" "1" "622" "68.9" "7.15" "37.56" "7" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf13424" "64837" "ENSG00000174996" "KLC2" "A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "6" "0" "0.903" "0.902" "1.100" "0.835" "0.923" "0.992" "0.700" "1.051" "4.389" "87.3" "78.8" "78.7" "96.0" "72.8" "80.5" "86.5" "61.0" "91.7" "383.0" "" "" "" "" "" "" "" "" "" "" "77.4" "65.3" "68.6" "71.8" "60.7" "74.0" "73.1" "50.5" "84.1" "383.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678846149867540289" "False" "High" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "0.000" "False" "37.878" "15" "8" "10" "8" "650" "72.5" "5.74" "36.62" "8" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "1.047" "1.047" "1.106" "1.079" "0.951" "1.201" "0.807" "1.052" "6.154" "197.3" "206.7" "206.5" "218.3" "213.0" "187.7" "237.0" "159.3" "207.6" "1214.5" "" "" "" "" "" "" "" "" "" "" "175.0" "171.2" "180.2" "163.2" "177.6" "172.4" "200.3" "131.7" "190.4" "1214.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "37.869" "10" "5" "8" "5" "458" "48.8" "10.07" "30.09" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Mitochondrial protein degradation" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "6" "0" "0.965" "0.979" "0.881" "0.981" "0.998" "0.914" "0.937" "0.915" "0.420" "736.1" "710.0" "720.3" "648.2" "722.0" "734.5" "672.9" "689.7" "673.8" "308.8" "" "" "" "" "" "" "" "" "" "" "652.7" "588.1" "628.5" "484.8" "602.0" "674.7" "568.7" "570.1" "617.9" "308.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "High" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.000" "False" "37.805" "48" "7" "13" "7" "119" "13.6" "5.38" "52.94" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Ciliary landscape" "8" "0" "0.965" "0.980" "0.928" "0.996" "0.949" "0.836" "0.942" "0.995" "0.615" "2074.9" "2001.5" "2033.6" "1925.6" "2067.0" "1968.1" "1734.1" "1953.7" "2064.4" "1275.7" "" "" "" "" "" "" "" "" "" "" "1839.9" "1658.0" "1774.4" "1440.1" "1723.6" "1807.9" "1465.6" "1614.9" "1893.3" "1275.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5357467251583528977" "False" "High" "IsMasterProtein" "Q49AR2" "UPF0489 protein C5orf22 OS=Homo sapiens OX=9606 GN=C5orf22 PE=1 SV=2" "0.000" "False" "37.727" "18" "6" "7" "6" "442" "49.9" "4.78" "28.13" "6" "" "" "" "Pf12640" "55322" "ENSG00000082213" "C5orf22" "hsa:55322; Q49AR2; Q8ND28; Q8WU61; Q9NUR1" "" "" "0" "0" "1.031" "1.030" "1.028" "0.998" "0.991" "1.057" "1.109" "1.055" "1.139" "1140.7" "1175.5" "1175.5" "1172.3" "1137.9" "1130.0" "1205.1" "1264.8" "1203.6" "1299.6" "" "" "" "" "" "" "" "" "" "" "1011.5" "973.7" "1025.6" "876.7" "948.9" "1038.0" "1018.5" "1045.5" "1103.9" "1299.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4914593963434688361" "False" "High" "IsMasterProtein" "Q6P3X3" "Tetratricopeptide repeat protein 27 OS=Homo sapiens OX=9606 GN=TTC27 PE=1 SV=1" "0.000" "False" "37.713" "10" "9" "11" "8" "843" "96.6" "5.59" "39.80" "9" "" "" "" "Pf07719" "55622" "ENSG00000018699" "TTC27" "A6NKJ0; hsa:55622; Q6P3X3; Q96SS5; Q9BVF1; Q9NWR4; Q9NXG4" "" "" "0" "1" "1.014" "0.908" "1.114" "0.990" "0.935" "1.050" "0.554" "0.904" "8.919" "348.1" "353.1" "316.0" "387.8" "344.6" "325.4" "365.6" "192.8" "314.7" "3104.9" "" "" "" "" "" "" "" "" "" "" "308.7" "292.5" "275.7" "290.0" "287.3" "298.9" "309.0" "159.4" "288.6" "3104.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5399791769626457574" "False" "High" "IsMasterProtein" "Q9UMS0" "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Homo sapiens OX=9606 GN=NFU1 PE=1 SV=2" "0.000" "False" "37.660" "26" "5" "11" "5" "254" "28.4" "5.07" "42.91" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf01106, Pf08712" "27247" "ENSG00000169599" "NFU1" "B4DUL9; hsa:27247; Q53QE5; Q6VNZ8; Q7Z5B1; Q7Z5B2; Q9UMS0; Q9Y322" "" "Iron-sulfur cluster biogenesis" "1" "0" "1.004" "0.998" "1.031" "1.036" "1.018" "1.010" "0.995" "1.004" "0.505" "1371.7" "1377.0" "1369.2" "1413.8" "1420.4" "1396.2" "1386.0" "1364.9" "1377.8" "692.4" "" "" "" "" "" "" "" "" "" "" "1216.4" "1140.6" "1194.7" "1057.3" "1184.4" "1282.5" "1171.4" "1128.2" "1263.6" "692.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1696656026908675474" "False" "High" "IsMasterProtein" "Q9BS40" "Latexin OS=Homo sapiens OX=9606 GN=LXN PE=1 SV=2" "0.000" "False" "37.655" "36" "5" "7" "5" "222" "25.7" "5.78" "29.59" "5" "stress response;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf06907, Pf20630" "56925" "ENSG00000079257" "LXN" "hsa:56925; Q96PN2; Q9BS40; Q9NQS6" "" "" "0" "0" "0.988" "0.956" "1.003" "0.954" "0.969" "1.136" "1.082" "1.055" "1.193" "925.9" "915.0" "885.4" "928.3" "883.0" "897.0" "1051.9" "1001.5" "977.2" "1104.4" "" "" "" "" "" "" "" "" "" "" "821.0" "757.9" "772.6" "694.3" "736.3" "824.0" "889.1" "827.8" "896.2" "1104.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.000" "False" "37.653" "16" "6" "9" "6" "388" "43.9" "8.53" "32.08" "6" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "" "1" "0" "1.089" "1.078" "1.132" "1.147" "1.104" "1.169" "1.122" "1.137" "0.591" "1413.9" "1540.0" "1524.0" "1600.7" "1622.4" "1560.9" "1653.2" "1586.4" "1607.2" "835.4" "" "" "" "" "" "" "" "" "" "" "1253.8" "1275.6" "1329.8" "1197.1" "1352.9" "1433.9" "1397.2" "1311.3" "1474.1" "835.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "37.645" "24" "7" "12" "7" "275" "30.3" "7.50" "40.74" "7" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "0.995" "0.980" "1.011" "1.032" "1.112" "0.989" "0.852" "1.023" "3.610" "759.4" "755.6" "744.5" "767.7" "783.4" "844.8" "750.8" "646.9" "777.0" "2741.0" "" "" "" "" "" "" "" "" "" "" "673.4" "625.9" "649.7" "574.1" "653.3" "776.0" "634.6" "534.7" "712.6" "2741.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "High" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.000" "False" "37.640" "31" "10" "13" "10" "322" "36.1" "5.12" "41.67" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "2" "0" "0.960" "0.958" "1.005" "0.975" "0.962" "1.038" "0.361" "0.927" "12.100" "637.6" "611.9" "610.5" "640.8" "621.7" "613.1" "662.1" "230.2" "591.1" "7714.4" "" "" "" "" "" "" "" "" "" "" "565.4" "506.9" "532.7" "479.2" "518.4" "563.2" "559.6" "190.3" "542.1" "7714.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4923515790283792107" "False" "High" "IsMasterProtein" "Q7Z309" "PABIR family member 2 OS=Homo sapiens OX=9606 GN=PABIR2 PE=1 SV=2" "0.000" "False" "37.597" "24" "5" "8" "5" "247" "26.9" "6.37" "28.77" "5" "" "" "enzyme regulator activity" "" "159090" "ENSG00000156504" "PABIR2" "A8K902; hsa:159090; Q6PIM2; Q6ZU47; Q6ZV64; Q6ZVE4; Q7Z309; Q8TB75" "" "" "0" "0" "0.976" "0.963" "1.014" "0.956" "1.040" "1.023" "1.062" "1.047" "0.672" "987.9" "964.3" "951.8" "1001.4" "944.7" "1027.5" "1010.7" "1049.6" "1034.8" "664.3" "" "" "" "" "" "" "" "" "" "" "876.1" "798.8" "830.5" "748.9" "787.7" "943.9" "854.2" "867.6" "949.1" "664.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2862738582169560407" "False" "High" "IsMasterProtein" "Q9H3S1" "Semaphorin-4A OS=Homo sapiens OX=9606 GN=SEMA4A PE=1 SV=2" "0.000" "False" "37.549" "14" "10" "11" "10" "761" "83.5" "6.84" "35.44" "10" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf01403, Pf01437" "64218" "ENSG00000196189" "SEMA4A" "B2RDH8; B3KR76; hsa:64218; Q5TCI5; Q5TCJ6; Q8WUA9; Q9H3S1" "Other semaphorin interactions" "Neurogenesis regulation in the olfactory epithelium" "2" "0" "1.062" "0.979" "1.064" "1.019" "1.055" "1.119" "1.051" "1.050" "1.007" "435.0" "462.1" "425.9" "462.8" "443.4" "459.1" "486.8" "457.0" "456.8" "437.9" "" "" "" "" "" "" "" "" "" "" "385.7" "382.8" "371.6" "346.1" "369.8" "421.7" "411.5" "377.7" "419.0" "437.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1415915778275113183" "False" "High" "IsMasterProtein" "Q7L273" "BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens OX=9606 GN=KCTD9 PE=1 SV=1" "0.000" "False" "37.532" "24" "6" "7" "6" "389" "42.5" "6.37" "28.54" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "" "other molecular function" "Pf00805, Pf02214, Pf11834" "54793" "ENSG00000104756" "KCTD9" "hsa:54793; Q6NUM8; Q7L273; Q9NXV4" "" "" "0" "0" "1.184" "1.015" "1.099" "1.163" "1.000" "1.103" "1.053" "1.051" "0.724" "162.5" "192.4" "164.9" "178.6" "188.9" "162.5" "179.2" "171.1" "170.7" "117.6" "" "" "" "" "" "" "" "" "" "" "144.1" "159.4" "143.9" "133.6" "157.6" "149.2" "151.5" "141.4" "156.6" "117.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "High" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.000" "False" "37.518" "32" "4" "8" "4" "136" "14.9" "9.31" "30.68" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "1.008" "1.048" "1.044" "1.034" "1.004" "1.018" "1.026" "1.006" "0.810" "941.0" "948.2" "986.0" "982.1" "973.3" "945.2" "957.6" "965.1" "946.2" "762.5" "" "" "" "" "" "" "" "" "" "" "834.5" "785.5" "860.3" "734.5" "811.6" "868.3" "809.3" "797.7" "867.8" "762.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "37.473" "35" "8" "16" "8" "193" "20.8" "5.31" "56.45" "8" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Neutrophil degranulation; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases" "3" "0" "0.980" "1.066" "0.956" "1.004" "1.015" "1.009" "1.021" "1.053" "0.547" "1884.0" "1846.7" "2008.1" "1801.1" "1891.4" "1912.0" "1900.7" "1923.4" "1983.7" "1029.9" "" "" "" "" "" "" "" "" "" "" "1670.7" "1529.7" "1752.2" "1347.0" "1577.2" "1756.4" "1606.4" "1589.8" "1819.3" "1029.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5100891898626735389" "False" "High" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "0.000" "False" "37.454" "37" "11" "15" "11" "291" "32.5" "9.14" "45.42" "11" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "Phase I - Functionalization of compounds" "" "1" "0" "0.976" "1.010" "1.074" "1.045" "1.029" "1.084" "1.063" "0.957" "0.527" "1166.2" "1137.6" "1178.3" "1252.5" "1218.6" "1200.6" "1264.2" "1239.8" "1116.3" "615.0" "" "" "" "" "" "" "" "" "" "" "1034.1" "942.4" "1028.1" "936.7" "1016.1" "1102.9" "1068.4" "1024.8" "1023.8" "615.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.000" "False" "37.449" "42" "6" "8" "6" "154" "16.5" "5.25" "32.63" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "Mitochondrial iron-sulfur cluster biogenesis" "" "1" "0" "1.010" "1.067" "1.205" "1.124" "0.992" "1.069" "1.105" "1.070" "0.643" "279.1" "281.9" "297.9" "336.4" "313.8" "276.8" "298.2" "308.5" "298.5" "179.4" "" "" "" "" "" "" "" "" "" "" "247.5" "233.5" "259.9" "251.6" "261.6" "254.3" "252.1" "255.0" "273.8" "179.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.000" "False" "37.440" "14" "7" "8" "7" "659" "76.2" "7.77" "32.32" "7" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "FCGR3A-mediated phagocytosis; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "20" "0" "1.099" "0.951" "1.082" "1.018" "0.933" "1.091" "0.538" "0.949" "9.574" "509.4" "559.9" "484.6" "550.9" "518.8" "475.3" "555.9" "274.0" "483.3" "4876.5" "" "" "" "" "" "" "" "" "" "" "451.7" "463.8" "422.8" "412.0" "432.6" "436.6" "469.8" "226.5" "443.2" "4876.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8961190954250988131" "False" "High" "IsMasterProtein" "Q16891" "MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1" "0.000" "False" "37.432" "11" "9" "10" "9" "758" "83.6" "6.48" "30.52" "9" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09731" "10989" "ENSG00000132305" "IMMT" "B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2" "Cristae formation" "" "1" "0" "1.020" "1.011" "1.104" "1.077" "0.983" "1.125" "1.056" "0.986" "0.322" "1180.8" "1204.9" "1193.7" "1303.8" "1271.9" "1160.4" "1328.0" "1247.1" "1164.2" "380.4" "" "" "" "" "" "" "" "" "" "" "1047.1" "998.1" "1041.6" "975.1" "1060.6" "1066.0" "1122.4" "1030.8" "1067.7" "380.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "37.426" "46" "5" "8" "5" "147" "15.7" "6.30" "34.38" "5" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "" "3" "0" "0.958" "0.952" "0.954" "1.012" "0.925" "0.971" "1.052" "0.999" "0.431" "463.5" "444.3" "441.2" "442.2" "469.1" "428.7" "449.9" "487.5" "463.0" "199.7" "" "" "" "" "" "" "" "" "" "" "411.0" "368.0" "385.0" "330.7" "391.2" "393.8" "380.3" "402.9" "424.6" "199.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "37.371" "29" "6" "22" "6" "178" "20.5" "8.59" "68.58" "6" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "1.042" "1.024" "0.997" "1.004" "1.042" "1.029" "0.987" "1.034" "0.550" "1475.6" "1537.7" "1510.4" "1470.5" "1481.9" "1537.5" "1518.8" "1456.9" "1525.7" "811.5" "" "" "" "" "" "" "" "" "" "" "1308.6" "1273.7" "1317.9" "1099.7" "1235.7" "1412.4" "1283.7" "1204.2" "1399.3" "811.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219092479354345629" "False" "High" "IsMasterProtein" "O94855" "Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2" "0.000" "False" "37.351" "9" "7" "10" "7" "1032" "112.9" "7.25" "33.70" "7" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9871" "ENSG00000150961" "SEC24D" "hsa:9871; O94855; Q8IYI7" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.038" "0.940" "0.972" "0.862" "0.867" "0.839" "0.839" "0.902" "1.734" "1638.3" "1701.3" "1539.8" "1592.0" "1411.5" "1421.2" "1373.7" "1374.9" "1478.1" "2840.8" "" "" "" "" "" "" "" "" "" "" "1452.8" "1409.2" "1343.6" "1190.6" "1177.0" "1305.5" "1161.0" "1136.4" "1355.6" "2840.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "37.343" "20" "3" "9" "3" "119" "13.3" "11.56" "37.09" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA Splicing - Major Pathway; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "0.751" "0.752" "0.691" "0.835" "0.823" "0.816" "0.829" "0.754" "0.522" "550.7" "413.7" "414.4" "380.5" "460.1" "453.3" "449.1" "456.7" "415.1" "287.4" "" "" "" "" "" "" "" "" "" "" "488.3" "342.7" "361.6" "284.6" "383.6" "416.4" "379.6" "377.5" "380.7" "287.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2050370214376890264" "False" "High" "IsMasterProtein" "O76075" "DNA fragmentation factor subunit beta OS=Homo sapiens OX=9606 GN=DFFB PE=1 SV=1" "0.000" "False" "37.341" "17" "5" "11" "5" "338" "39.1" "9.00" "34.75" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02017, Pf09230" "1677" "ENSG00000169598" "DFFB" "hsa:1677; O60521; O76075; Q5SR22; Q9BYI4; Q9BYI5; Q9BYI6" "Apoptosis induced DNA fragmentation" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "4" "0" "0.967" "0.938" "1.123" "0.994" "1.005" "1.023" "1.007" "0.842" "0.722" "1365.7" "1320.9" "1281.3" "1533.4" "1358.0" "1372.3" "1396.5" "1374.8" "1150.4" "986.0" "" "" "" "" "" "" "" "" "" "" "1211.0" "1094.2" "1118.0" "1146.7" "1132.3" "1260.6" "1180.3" "1136.4" "1055.1" "986.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213729863308039280" "False" "High" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "0.000" "False" "37.312" "31" "8" "13" "8" "258" "29.2" "9.01" "42.70" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "0.967" "0.960" "1.000" "1.001" "0.997" "0.988" "0.934" "0.929" "1.098" "1900.1" "1836.8" "1824.3" "1900.5" "1902.9" "1893.8" "1876.9" "1774.8" "1765.6" "2085.6" "" "" "" "" "" "" "" "" "" "" "1685.0" "1521.5" "1591.8" "1421.3" "1586.8" "1739.6" "1586.3" "1467.0" "1619.3" "2085.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4119933875415276465" "False" "High" "IsMasterProtein" "P07902" "Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3" "0.000" "False" "37.290" "16" "5" "6" "5" "379" "43.3" "6.99" "25.45" "5" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01087, Pf02744" "2592" "ENSG00000213930" "GALT" "B4E097; E7ET32; hsa:2592; P07902; Q14355; Q14356; Q14357; Q14358; Q14359; Q14360; Q14361; Q14363; Q14364; Q14365; Q14369; Q14370; Q14371; Q14372; Q14373; Q14374; Q14375; Q14377; Q14378; Q14380; Q14381; Q14382; Q14383; Q14384; Q14385; Q14386; Q14387; Q14389; Q16766; Q53XK1; Q5VZ81; Q96BY1" "Defective GALT can cause GALCT; Galactose catabolism" "Disorders of galactose metabolism ; Primary ovarian insufficiency" "4" "0" "0.919" "0.949" "1.008" "0.921" "0.979" "1.008" "1.011" "1.048" "0.539" "348.7" "320.5" "330.8" "351.5" "321.0" "341.3" "351.6" "352.4" "365.6" "188.1" "" "" "" "" "" "" "" "" "" "" "309.2" "265.5" "288.7" "262.9" "267.7" "313.5" "297.2" "291.3" "335.3" "188.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "37.148" "5" "10" "10" "10" "2012" "227.8" "6.19" "34.51" "10" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "29" "0" "1.095" "0.934" "1.172" "1.047" "0.948" "1.182" "0.977" "1.131" "4.799" "505.5" "553.7" "471.9" "592.4" "529.4" "479.2" "597.4" "494.1" "571.6" "2426.1" "" "" "" "" "" "" "" "" "" "" "448.3" "458.6" "411.8" "443.1" "441.5" "440.2" "504.9" "408.4" "524.2" "2426.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5145837311521029190" "False" "High" "IsMasterProtein" "Q8N183" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1" "0.000" "False" "37.147" "43" "7" "9" "7" "169" "19.8" "8.97" "32.81" "7" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf05071" "91942" "ENSG00000164182" "NDUFAF2" "A8K5I1; hsa:91942; Q8N183" "Complex I biogenesis" "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "2" "0" "0.988" "1.000" "0.953" "0.967" "0.988" "1.006" "0.980" "1.026" "0.393" "1241.6" "1226.9" "1241.9" "1182.9" "1200.0" "1227.2" "1248.9" "1217.3" "1273.5" "487.9" "" "" "" "" "" "" "" "" "" "" "1101.0" "1016.3" "1083.6" "884.6" "1000.6" "1127.3" "1055.6" "1006.2" "1168.0" "487.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "37.109" "26" "7" "9" "6" "320" "33.6" "7.77" "37.63" "7" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Glutamate and glutamine metabolism" "Metabolic reprogramming in colon cancer" "2" "0" "1.089" "1.042" "1.032" "1.111" "1.158" "0.982" "0.997" "0.965" "0.553" "919.3" "1000.8" "958.4" "949.0" "1021.2" "1064.3" "902.6" "916.4" "887.4" "508.3" "" "" "" "" "" "" "" "" "" "" "815.2" "829.0" "836.2" "709.7" "851.5" "977.7" "762.8" "757.4" "813.9" "508.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5653084663226725114" "False" "High" "IsMasterProtein" "Q96JJ3" "Engulfment and cell motility protein 2 OS=Homo sapiens OX=9606 GN=ELMO2 PE=1 SV=2" "0.000" "False" "37.075" "12" "9" "15" "6" "720" "82.6" "5.90" "40.54" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf04727, Pf11841, Pf16457" "63916" "ENSG00000062598" "ELMO2" "E1P5T3; hsa:63916; Q5JVZ6; Q7Z5G9; Q96CJ2; Q96JJ3; Q96ME5; Q96PA9; Q9H938; Q9H9L5; Q9HAH0; Q9NQQ6" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; RHOG GTPase cycle" "" "5" "0" "0.993" "0.849" "0.958" "0.895" "0.846" "0.914" "0.312" "0.890" "11.488" "375.6" "373.1" "318.9" "359.8" "336.0" "317.6" "343.2" "117.1" "334.3" "4314.4" "" "" "" "" "" "" "" "" "" "" "333.0" "309.1" "278.3" "269.1" "280.2" "291.7" "290.1" "96.8" "306.6" "4314.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.000" "False" "37.034" "11" "6" "7" "6" "753" "80.7" "8.09" "29.38" "6" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "1.093" "0.951" "1.233" "1.067" "0.999" "1.330" "1.165" "1.050" "0.948" "502.5" "549.3" "477.9" "619.4" "536.3" "502.0" "668.2" "585.4" "527.8" "476.2" "" "" "" "" "" "" "" "" "" "" "445.6" "455.0" "417.0" "463.2" "447.2" "461.1" "564.7" "483.9" "484.1" "476.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "37.004" "19" "8" "13" "6" "406" "46.6" "6.16" "46.64" "8" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "1.048" "0.961" "1.024" "0.981" "0.986" "1.269" "0.994" "1.190" "5.118" "819.7" "858.6" "788.1" "839.4" "804.3" "808.3" "1039.8" "814.7" "975.2" "4194.8" "" "" "" "" "" "" "" "" "" "" "726.9" "711.2" "687.6" "627.8" "670.7" "742.5" "878.8" "673.4" "894.4" "4194.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230777369959258810" "False" "High" "IsMasterProtein" "O95239" "Chromosome-associated kinesin KIF4A OS=Homo sapiens OX=9606 GN=KIF4A PE=1 SV=3" "0.000" "False" "36.991" "6" "8" "9" "8" "1232" "139.8" "6.27" "27.18" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "24137" "ENSG00000090889" "KIF4A" "B2R7V5; D3DVU4; hsa:24137; O95239; Q86TN3; Q86XX7; Q9NNY6; Q9NY24; Q9UMW3" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "Retinoblastoma gene in cancer" "5" "0" "1.057" "0.975" "1.131" "1.035" "1.059" "0.968" "0.821" "1.039" "4.885" "228.9" "241.9" "223.2" "258.8" "236.8" "242.3" "221.5" "187.9" "237.8" "1117.9" "" "" "" "" "" "" "" "" "" "" "202.9" "200.4" "194.8" "193.6" "197.5" "222.6" "187.2" "155.3" "218.1" "1117.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8205566320687520923" "False" "High" "IsMasterProtein" "Q9NSK0" "Kinesin light chain 4 OS=Homo sapiens OX=9606 GN=KLC4 PE=1 SV=3" "0.000" "False" "36.985" "12" "7" "9" "3" "619" "68.6" "6.18" "32.30" "7" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf13374, Pf13424" "89953" "ENSG00000137171" "KLC4" "B3KNY4; B3KPI3; B3KSQ3; B4DME9; hsa:89953; Q66K28; Q96EG6; Q9NSK0" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "6" "0" "0.877" "0.913" "1.155" "0.968" "1.008" "0.972" "0.746" "0.897" "3.973" "123.0" "107.9" "112.3" "142.1" "119.0" "123.9" "119.6" "91.8" "110.3" "488.6" "" "" "" "" "" "" "" "" "" "" "109.1" "89.3" "98.0" "106.3" "99.2" "113.8" "101.1" "75.9" "101.2" "488.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192519440703409270" "False" "High" "IsMasterProtein" "Q8NB37" "Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1" "0.000" "False" "36.891" "38" "5" "6" "5" "220" "23.3" "6.61" "29.71" "5" "other metabolic processes" "other cell component" "other molecular function" "" "347862" "ENSG00000177225" "GATD1" "B7ZKW5; hsa:347862; Q2NL76; Q6ZQY0; Q8NAE0; Q8NB37" "" "" "0" "0" "0.973" "0.965" "0.982" "1.056" "1.019" "0.950" "0.965" "0.896" "0.665" "298.7" "290.5" "288.1" "293.3" "315.5" "304.4" "283.9" "288.1" "267.7" "198.6" "" "" "" "" "" "" "" "" "" "" "264.9" "240.6" "251.4" "219.4" "263.1" "279.7" "239.9" "238.2" "245.5" "198.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "High" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.000" "False" "36.852" "19" "7" "7" "7" "349" "38.2" "5.50" "27.80" "7" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "The role of GTSE1 in G2/M progression after G2 checkpoint" "" "1" "0" "1.012" "1.022" "1.049" "1.050" "1.088" "1.093" "1.100" "1.068" "0.857" "872.9" "883.3" "891.7" "915.8" "916.3" "949.4" "953.9" "960.0" "932.0" "748.2" "" "" "" "" "" "" "" "" "" "" "774.1" "731.7" "778.1" "684.9" "764.1" "872.2" "806.2" "793.5" "854.8" "748.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3084811773954898757" "False" "High" "IsMasterProtein" "Q6BCY4" "NADH-cytochrome b5 reductase 2 OS=Homo sapiens OX=9606 GN=CYB5R2 PE=1 SV=1" "0.000" "False" "36.840" "26" "6" "8" "6" "276" "31.4" "8.50" "32.18" "6" "other metabolic processes;transport" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00175, Pf00970" "51700" "ENSG00000166394" "CYB5R2" "hsa:51700; Q6BCY4; Q9BVA3; Q9UF68; Q9UHJ0" "Erythrocytes take up carbon dioxide and release oxygen" "Oxidation by cytochrome P450" "2" "0" "1.050" "0.971" "1.098" "1.056" "1.105" "1.088" "1.038" "0.983" "0.723" "449.7" "472.3" "436.5" "493.7" "475.0" "497.0" "489.4" "466.8" "441.9" "325.0" "" "" "" "" "" "" "" "" "" "" "398.8" "391.2" "380.9" "369.2" "396.1" "456.6" "413.6" "385.8" "405.3" "325.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4281551287497306931" "False" "High" "IsMasterProtein" "Q9Y2B9" "cAMP-dependent protein kinase inhibitor gamma OS=Homo sapiens OX=9606 GN=PKIG PE=1 SV=1" "0.000" "False" "36.736" "72" "3" "10" "3" "76" "7.9" "4.25" "38.03" "3" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf02827" "11142" "ENSG00000168734" "PKIG" "hsa:11142; Q9Y2B9" "" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "2" "0" "0.957" "0.870" "0.958" "0.881" "0.923" "0.866" "0.868" "0.889" "0.506" "1017.5" "974.1" "885.5" "975.0" "896.6" "938.9" "881.0" "882.8" "904.7" "514.4" "" "" "" "" "" "" "" "" "" "" "902.3" "806.9" "772.6" "729.1" "747.6" "862.5" "744.6" "729.7" "829.8" "514.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "36.730" "36" "8" "9" "8" "282" "31.8" "4.83" "35.79" "8" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "10" "0" "1.003" "0.946" "1.092" "1.018" "0.956" "0.984" "1.010" "0.899" "0.915" "406.6" "407.9" "384.8" "444.1" "414.0" "388.6" "400.0" "410.5" "365.5" "372.1" "" "" "" "" "" "" "" "" "" "" "360.6" "337.9" "335.8" "332.2" "345.2" "356.9" "338.0" "339.3" "335.3" "372.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4417786093828078874" "False" "High" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0.000" "False" "36.728" "5" "11" "11" "11" "1944" "216.4" "6.30" "39.49" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf20518, Pf21282" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Senescence-Associated Secretory Phenotype (SASP); Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle; 2q13 copy number variation syndrome" "20" "0" "1.048" "0.984" "1.091" "1.096" "0.956" "1.148" "0.951" "0.963" "1.549" "186.5" "195.4" "183.6" "203.4" "204.4" "178.3" "214.1" "177.4" "179.7" "288.9" "" "" "" "" "" "" "" "" "" "" "165.4" "161.9" "160.2" "152.1" "170.4" "163.8" "181.0" "146.6" "164.8" "288.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "36.707" "10" "10" "10" "10" "1050" "119.5" "5.27" "27.31" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "12" "0" "1.063" "0.987" "1.096" "1.010" "0.966" "0.985" "0.588" "1.048" "7.378" "642.8" "683.1" "634.7" "704.3" "649.2" "620.6" "632.9" "378.0" "673.4" "4742.2" "" "" "" "" "" "" "" "" "" "" "570.0" "565.8" "553.8" "526.7" "541.3" "570.1" "534.9" "312.4" "617.6" "4742.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "36.679" "21" "3" "15" "3" "172" "18.6" "9.51" "53.74" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "0.986" "0.979" "0.928" "1.006" "1.027" "0.937" "0.981" "0.969" "0.504" "2076.4" "2047.2" "2032.3" "1926.7" "2087.8" "2131.9" "1945.6" "2036.1" "2012.9" "1047.2" "" "" "" "" "" "" "" "" "" "" "1841.3" "1695.8" "1773.3" "1441.0" "1741.0" "1958.4" "1644.4" "1683.0" "1846.1" "1047.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "36.655" "30" "2" "5" "2" "106" "11.8" "8.09" "25.75" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "Interconversion of nucleotide di- and triphosphates" "One-carbon metabolism" "2" "0" "0.952" "0.965" "0.988" "0.969" "0.998" "0.999" "0.972" "0.924" "0.449" "556.0" "529.6" "536.6" "549.4" "538.7" "555.0" "555.6" "540.3" "513.8" "249.4" "" "" "" "" "" "" "" "" "" "" "493.1" "438.7" "468.2" "410.9" "449.2" "509.8" "469.6" "446.6" "471.2" "249.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.000" "False" "36.542" "10" "8" "9" "8" "889" "98.3" "5.59" "33.01" "8" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "CDC42 GTPase cycle; RAC1 GTPase cycle" "" "2" "0" "0.990" "0.979" "1.105" "1.013" "1.065" "1.136" "1.024" "1.103" "0.931" "361.3" "357.6" "353.8" "399.1" "366.0" "384.9" "410.4" "370.1" "398.6" "336.4" "" "" "" "" "" "" "" "" "" "" "320.4" "296.2" "308.7" "298.5" "305.2" "353.6" "346.9" "305.9" "365.6" "336.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "262985657933925195" "False" "High" "IsMasterProtein" "Q969H6" "Ribonuclease P/MRP protein subunit POP5 OS=Homo sapiens OX=9606 GN=POP5 PE=1 SV=1" "0.000" "False" "36.534" "28" "3" "7" "3" "163" "18.8" "7.27" "27.49" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "51367" "ENSG00000167272" "POP5" "A6NL80; hsa:51367; Q53FS5; Q969H6; Q9Y2Q6" "tRNA processing in the nucleus" "" "1" "0" "1.015" "0.934" "1.059" "1.053" "0.915" "1.069" "1.027" "0.870" "0.662" "344.8" "350.1" "321.9" "365.3" "363.1" "315.4" "368.7" "354.2" "299.9" "228.3" "" "" "" "" "" "" "" "" "" "" "305.8" "290.0" "280.9" "273.2" "302.8" "289.7" "311.6" "292.7" "275.1" "228.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2834511568131292996" "False" "High" "IsMasterProtein" "O00329" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2" "0.000" "False" "36.521" "8" "10" "10" "8" "1044" "119.4" "7.18" "33.90" "10" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5293" "ENSG00000171608" "PIK3CD" "A6NCG0; G1FFP1; hsa:5293; O00329; O15445; Q5SR49" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; IL-3 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "56" "1" "1.031" "0.972" "1.033" "0.955" "0.873" "0.944" "0.816" "0.850" "2.170" "513.4" "529.2" "498.9" "530.4" "490.4" "448.3" "484.6" "418.8" "436.2" "1114.1" "" "" "" "" "" "" "" "" "" "" "455.2" "438.4" "435.3" "396.6" "408.9" "411.8" "409.6" "346.2" "400.1" "1114.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "36.511" "11" "7" "10" "5" "715" "80.7" "9.26" "34.63" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "Effect of progerin on genes involved in progeria; TAR syndrome" "8" "0" "1.162" "1.062" "1.270" "1.143" "1.106" "1.124" "1.154" "1.114" "1.752" "390.5" "454.0" "414.6" "496.1" "446.3" "432.0" "438.8" "450.5" "435.1" "684.0" "" "" "" "" "" "" "" "" "" "" "346.3" "376.0" "361.7" "371.0" "372.1" "396.8" "370.8" "372.3" "399.0" "684.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "36.418" "22" "11" "13" "10" "419" "48.0" "5.92" "40.46" "11" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "1.011" "0.896" "1.053" "0.956" "0.899" "0.985" "0.495" "0.971" "9.218" "766.4" "774.9" "686.7" "806.9" "732.6" "689.2" "754.6" "379.6" "743.9" "7065.0" "" "" "" "" "" "" "" "" "" "" "679.6" "641.9" "599.2" "603.4" "610.9" "633.1" "637.8" "313.8" "682.2" "7065.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "36.377" "32" "8" "12" "5" "266" "29.9" "7.74" "43.03" "8" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "17" "2" "1.012" "0.981" "1.009" "1.012" "1.029" "1.008" "1.077" "1.205" "0.644" "1317.7" "1332.9" "1292.6" "1329.5" "1333.3" "1356.5" "1328.2" "1418.5" "1587.7" "848.3" "" "" "" "" "" "" "" "" "" "" "1168.5" "1104.1" "1127.9" "994.3" "1111.8" "1246.1" "1122.5" "1172.5" "1456.2" "848.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500960934407520232" "False" "High" "IsMasterProtein" "O43716" "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1" "0.000" "False" "36.357" "54" "5" "6" "5" "136" "15.1" "5.05" "25.12" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf02686" "283459" "ENSG00000257218" "GATC" "B3KSU7; hsa:283459; O43716; Q3B824; Q3KNR8" "" "" "0" "0" "0.950" "1.009" "1.055" "0.949" "1.021" "0.915" "0.932" "0.883" "0.913" "387.5" "368.2" "391.1" "409.0" "367.6" "395.5" "354.5" "361.1" "342.1" "353.8" "" "" "" "" "" "" "" "" "" "" "343.6" "305.0" "341.3" "305.9" "306.6" "363.3" "299.6" "298.5" "313.7" "353.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354305271704446850" "False" "High" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "0.000" "False" "36.330" "5" "8" "8" "8" "1868" "208.3" "6.90" "28.61" "8" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "" "2" "0" "1.108" "1.129" "1.202" "1.138" "0.994" "1.195" "1.064" "1.038" "1.641" "528.6" "585.5" "597.1" "635.4" "601.6" "525.2" "631.5" "562.6" "548.7" "867.5" "" "" "" "" "" "" "" "" "" "" "468.8" "485.0" "521.0" "475.2" "501.7" "482.5" "533.7" "465.0" "503.2" "867.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "36.328" "29" "10" "12" "10" "306" "32.4" "9.17" "37.75" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "0.861" "0.835" "0.905" "0.821" "0.870" "0.806" "0.291" "0.763" "10.710" "877.9" "755.9" "733.2" "794.6" "720.9" "763.9" "707.7" "255.9" "670.0" "9402.3" "" "" "" "" "" "" "" "" "" "" "778.5" "626.2" "639.8" "594.3" "601.1" "701.7" "598.1" "211.5" "614.5" "9402.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "577500699946211837" "False" "High" "IsMasterProtein" "Q8NFQ8" "Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1" "0.000" "False" "36.324" "17" "7" "10" "6" "470" "51.2" "4.96" "35.87" "7" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf05609, Pf20443" "163590" "ENSG00000169905" "TOR1AIP2" "hsa:163590; Q8NFQ8" "" "" "0" "0" "0.944" "0.880" "0.998" "0.931" "0.955" "1.038" "1.018" "0.994" "0.347" "750.6" "708.4" "660.7" "748.8" "699.0" "717.1" "778.7" "764.1" "746.2" "260.1" "" "" "" "" "" "" "" "" "" "" "665.6" "586.8" "576.5" "560.0" "582.9" "658.8" "658.1" "631.5" "684.3" "260.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "High" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.000" "False" "36.321" "27" "5" "11" "5" "226" "24.4" "6.10" "32.54" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "61" "0" "0.938" "0.899" "0.928" "0.901" "0.900" "0.886" "0.685" "1.007" "4.217" "327.2" "307.0" "294.3" "303.5" "294.8" "294.4" "290.0" "224.3" "329.5" "1379.8" "" "" "" "" "" "" "" "" "" "" "290.2" "254.3" "256.8" "227.0" "245.8" "270.4" "245.1" "185.4" "302.2" "1379.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864018122010782004" "False" "High" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "0.000" "False" "36.307" "33" "4" "6" "4" "140" "15.0" "6.99" "21.27" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways" "3" "0" "0.970" "1.007" "0.956" "0.985" "1.248" "1.062" "1.153" "1.011" "0.685" "379.1" "367.8" "381.7" "362.5" "373.5" "473.2" "402.6" "437.0" "383.2" "259.8" "" "" "" "" "" "" "" "" "" "" "336.1" "304.7" "333.1" "271.1" "311.5" "434.7" "340.2" "361.2" "351.5" "259.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243643898250283401" "False" "High" "IsMasterProtein" "Q9UI08" "Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2" "0.000" "False" "36.277" "16" "5" "7" "5" "416" "44.6" "8.84" "29.85" "5" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "51466" "ENSG00000196405" "EVL" "A8K105; B7Z3I5; hsa:51466; O95884; Q7Z522; Q8TBV1; Q9UF25; Q9UI08; Q9UIC2" "Generation of second messenger molecules; RHO GTPases Activate Formins; Signaling by ROBO receptors" "" "3" "0" "1.026" "1.009" "1.062" "1.035" "1.095" "1.074" "0.923" "1.071" "3.823" "262.4" "269.3" "264.8" "278.8" "271.6" "287.2" "281.7" "242.3" "281.0" "1003.2" "" "" "" "" "" "" "" "" "" "" "232.7" "223.1" "231.1" "208.5" "226.5" "263.8" "238.1" "200.3" "257.7" "1003.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "36.272" "24" "4" "17" "4" "102" "11.5" "4.16" "63.89" "4" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "" "IL-18 signaling pathway" "1" "0" "0.906" "0.933" "0.936" "0.953" "0.885" "0.941" "0.982" "0.982" "0.402" "3097.8" "2808.0" "2889.1" "2899.6" "2953.5" "2743.1" "2915.1" "3041.2" "3041.3" "1244.0" "" "" "" "" "" "" "" "" "" "" "2747.1" "2326.0" "2520.9" "2168.5" "2462.8" "2519.8" "2463.7" "2513.7" "2789.3" "1244.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412220755654312839" "False" "High" "IsMasterProtein" "Q15652" "Probable JmjC domain-containing histone demethylation protein 2C OS=Homo sapiens OX=9606 GN=JMJD1C PE=1 SV=2" "0.000" "False" "36.243" "4" "12" "12" "12" "2540" "284.3" "7.87" "38.89" "12" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "221037" "ENSG00000171988" "JMJD1C" "A0T124; hsa:221037; Q15652; Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7" "Factors involved in megakaryocyte development and platelet production" "Pathways affected in adenoid cystic carcinoma" "2" "0" "0.954" "0.961" "0.865" "0.904" "0.939" "0.881" "0.885" "0.901" "0.958" "1629.5" "1554.5" "1566.2" "1409.7" "1472.8" "1530.1" "1434.8" "1442.4" "1467.9" "1561.6" "" "" "" "" "" "" "" "" "" "" "1445.0" "1287.7" "1366.6" "1054.3" "1228.1" "1405.6" "1212.6" "1192.3" "1346.3" "1561.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7478830788962877121" "False" "High" "IsMasterProtein" "Q9Y3C4" "EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1" "0.000" "False" "36.225" "19" "3" "14" "3" "175" "19.6" "6.79" "53.77" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08617" "51002" "ENSG00000144034; ENSG00000291480" "TPRKB" "D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.026" "0.991" "1.076" "1.051" "1.040" "1.049" "1.048" "0.965" "0.581" "949.1" "973.6" "940.9" "1021.3" "997.5" "986.8" "996.1" "994.5" "915.8" "551.3" "" "" "" "" "" "" "" "" "" "" "841.7" "806.5" "821.0" "763.8" "831.8" "906.5" "841.8" "822.0" "839.9" "551.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5702774175857427246" "False" "High" "IsMasterProtein" "Q02078" "Myocyte-specific enhancer factor 2A OS=Homo sapiens OX=9606 GN=MEF2A PE=1 SV=1" "0.000" "False" "36.208" "14" "6" "11" "4" "507" "54.8" "7.91" "40.05" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4205" "ENSG00000068305" "MEF2A" "B4DFQ7; F6XG23; hsa:4205; O43814; Q02078; Q14223; Q14224; Q59GX4; Q7Z6C9; Q96D14" "Myogenesis; ERK/MAPK targets" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; TGF-beta signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; 2q37 copy number variation syndrome" "13" "0" "0.964" "0.960" "1.037" "1.014" "0.995" "1.095" "1.089" "1.056" "0.867" "577.5" "556.4" "554.5" "598.8" "585.4" "574.8" "632.3" "628.9" "610.0" "500.6" "" "" "" "" "" "" "" "" "" "" "512.1" "460.9" "483.8" "447.8" "488.1" "528.0" "534.4" "519.8" "559.4" "500.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8834965082719872925" "False" "High" "IsMasterProtein" "Q96EQ0" "Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1" "0.000" "False" "36.194" "31" "8" "9" "8" "304" "33.4" "4.92" "33.16" "8" "cell organization and biogenesis;other biological processes" "other membranes;cytosol" "other molecular function" "Pf00515, Pf13414, Pf16546" "54557" "ENSG00000197860" "SGTB" "hsa:54557; Q96EQ0" "" "" "0" "0" "1.120" "1.035" "0.907" "0.971" "1.053" "0.971" "1.028" "1.116" "0.773" "928.0" "1039.1" "960.1" "842.0" "901.1" "977.5" "900.9" "953.7" "1035.3" "717.6" "" "" "" "" "" "" "" "" "" "" "822.9" "860.8" "837.7" "629.7" "751.4" "897.9" "761.4" "788.3" "949.5" "717.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065211085214910630" "False" "High" "IsMasterProtein" "Q96EL3" "Large ribosomal subunit protein mL53 OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1" "0.000" "False" "36.118" "63" "6" "8" "6" "112" "12.1" "8.76" "30.94" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10780" "116540" "ENSG00000204822" "MRPL53" "hsa:116540; Q96EL3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.984" "1.082" "0.985" "1.051" "0.986" "1.116" "1.059" "1.122" "1.047" "588.7" "579.5" "636.7" "579.9" "618.5" "580.3" "656.8" "623.6" "660.6" "616.4" "" "" "" "" "" "" "" "" "" "" "522.1" "480.0" "555.6" "433.7" "515.7" "533.1" "555.1" "515.4" "605.9" "616.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.000" "False" "36.075" "14" "12" "12" "12" "789" "90.8" "5.43" "33.96" "12" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "" "2" "0" "0.980" "0.931" "0.839" "0.855" "0.802" "0.784" "0.754" "0.919" "1.439" "467.1" "457.8" "434.8" "391.7" "399.6" "374.4" "366.1" "352.1" "429.2" "672.2" "" "" "" "" "" "" "" "" "" "" "414.2" "379.2" "379.4" "293.0" "333.2" "343.9" "309.4" "291.0" "393.6" "672.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6779909124529057950" "False" "High" "IsMasterProtein" "Q16773" "Kynurenine--oxoglutarate transaminase 1 OS=Homo sapiens OX=9606 GN=KYAT1 PE=1 SV=1" "0.000" "False" "36.048" "17" "6" "9" "5" "422" "47.8" "6.47" "37.26" "6" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00155" "883" "ENSG00000171097" "KYAT1" "hsa:883; Q16773; Q5T275; Q8N191" "Tryptophan catabolism; Glutamate and glutamine metabolism; Phenylalanine metabolism" "" "3" "0" "1.101" "1.032" "1.063" "1.040" "1.088" "1.098" "1.069" "1.035" "0.553" "626.1" "689.4" "646.4" "665.4" "651.2" "681.3" "687.6" "669.0" "648.3" "346.3" "" "" "" "" "" "" "" "" "" "" "555.2" "571.1" "564.0" "497.7" "543.0" "625.9" "581.1" "553.0" "594.5" "346.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8568450672967987050" "False" "High" "IsMasterProtein" "Q9NWX5" "Ankyrin repeat and SOCS box protein 6 OS=Homo sapiens OX=9606 GN=ASB6 PE=1 SV=1" "0.000" "False" "36.046" "17" "5" "6" "5" "421" "47.1" "6.01" "29.15" "5" "protein metabolism;other metabolic processes;signal transduction" "cytosol" "" "Pf07525, Pf12796, Pf13637" "140459" "ENSG00000148331" "ASB6" "hsa:140459; Q5SZB7; Q9BV15; Q9NWX5" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "1.054" "0.996" "1.022" "0.987" "0.981" "0.949" "0.932" "0.916" "1.190" "551.1" "581.0" "548.7" "563.0" "544.1" "540.7" "523.2" "513.6" "504.6" "655.7" "" "" "" "" "" "" "" "" "" "" "488.7" "481.2" "478.8" "421.0" "453.7" "496.7" "442.2" "424.5" "462.8" "655.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4834847741093139597" "False" "High" "IsMasterProtein" "P30711" "Glutathione S-transferase theta-1 OS=Homo sapiens OX=9606 GN=GSTT1 PE=1 SV=4" "0.000" "False" "35.946" "20" "4" "8" "4" "240" "27.3" "7.49" "29.29" "4" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00043, Pf13417" "2952" "ENSG00000277656" "GSTT1" "hsa:2952; O00226; P30711; Q5TZY2; Q6IC69; Q969K8; Q96IY3" "Paracetamol ADME; Glutathione conjugation" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "7" "0" "1.034" "0.951" "1.035" "1.062" "1.008" "1.052" "1.022" "0.982" "0.517" "617.2" "638.0" "586.9" "638.8" "655.8" "622.1" "649.5" "631.0" "606.2" "319.0" "" "" "" "" "" "" "" "" "" "" "547.3" "528.5" "512.1" "477.8" "546.8" "571.4" "548.9" "521.6" "555.9" "319.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7799027560696546609" "False" "High" "IsMasterProtein" "Q49MG5" "Microtubule-associated protein 9 OS=Homo sapiens OX=9606 GN=MAP9 PE=1 SV=3" "0.000" "False" "35.924" "15" "9" "9" "9" "647" "74.2" "7.80" "34.86" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "" "79884" "ENSG00000164114" "MAP9" "hsa:79884; Q49MG5; Q4W5I7; Q68DU1; Q9H781; Q9H7B6" "" "" "0" "0" "1.014" "0.980" "0.998" "0.976" "1.037" "0.974" "0.929" "0.980" "0.875" "706.2" "716.3" "692.0" "704.5" "689.1" "732.1" "687.7" "656.3" "692.1" "617.9" "" "" "" "" "" "" "" "" "" "" "626.2" "593.4" "603.8" "526.8" "574.6" "672.5" "581.3" "542.5" "634.7" "617.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "35.864" "38" "8" "26" "7" "177" "19.2" "8.07" "69.70" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "" "2" "0" "1.035" "0.997" "1.016" "0.995" "1.031" "1.043" "1.021" "0.990" "1.240" "1072.1" "1109.7" "1069.1" "1089.6" "1066.4" "1105.7" "1118.3" "1094.2" "1061.0" "1328.8" "" "" "" "" "" "" "" "" "" "" "950.7" "919.2" "932.8" "814.9" "889.2" "1015.7" "945.1" "904.4" "973.0" "1328.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "High" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.000" "False" "35.839" "15" "9" "9" "6" "651" "70.8" "8.51" "35.11" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "10" "2" "1.010" "1.071" "1.126" "1.065" "1.017" "1.111" "1.092" "1.019" "0.837" "777.2" "784.6" "832.7" "875.1" "827.4" "790.7" "863.1" "848.3" "791.7" "650.4" "" "" "" "" "" "" "" "" "" "" "689.2" "650.0" "726.6" "654.5" "689.9" "726.3" "729.4" "701.2" "726.1" "650.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "35.835" "33" "3" "19" "2" "112" "12.3" "9.09" "67.50" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "MASTL Facilitates Mitotic Progression" "" "1" "0" "0.970" "0.956" "1.065" "1.007" "1.094" "0.969" "1.011" "0.983" "0.723" "948.5" "920.5" "906.3" "1009.9" "954.8" "1037.3" "919.4" "959.4" "932.3" "685.8" "" "" "" "" "" "" "" "" "" "" "841.1" "762.5" "790.8" "755.2" "796.1" "952.8" "777.0" "793.0" "855.0" "685.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5573566891233996467" "False" "High" "IsMasterProtein" "Q96FV2" "Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3" "0.000" "False" "35.827" "15" "6" "8" "6" "425" "46.6" "5.67" "24.41" "6" "protein metabolism" "" "other molecular function" "Pf03577" "90507" "ENSG00000141295" "SCRN2" "A8K3N1; B7Z8S7; E9PBV5; hsa:90507; Q96AC3; Q96FV2; Q9BU04" "" "" "0" "0" "1.031" "1.068" "0.942" "0.968" "1.005" "0.928" "0.931" "0.980" "1.087" "797.1" "821.6" "851.1" "751.0" "771.7" "800.7" "739.5" "742.2" "781.3" "866.2" "" "" "" "" "" "" "" "" "" "" "706.9" "680.5" "742.6" "561.6" "643.5" "735.5" "625.0" "613.4" "716.6" "866.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877552904475964910" "False" "High" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "0.000" "False" "35.789" "29" "7" "11" "7" "227" "26.1" "8.28" "40.22" "7" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "Mitochondrial protein import; Cristae formation" "" "2" "0" "0.949" "0.964" "0.850" "0.890" "0.974" "0.836" "0.897" "0.878" "0.225" "1475.0" "1400.3" "1421.5" "1253.8" "1312.4" "1437.1" "1232.6" "1323.1" "1295.1" "332.0" "" "" "" "" "" "" "" "" "" "" "1308.0" "1159.9" "1240.3" "937.7" "1094.3" "1320.1" "1041.8" "1093.7" "1187.8" "332.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-843135532772952093" "False" "High" "IsMasterProtein" "Q8TD55" "Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1" "0.000" "False" "35.781" "15" "8" "9" "8" "490" "53.3" "5.43" "30.19" "8" "other biological processes" "non-structural extracellular;other cell component" "" "Pf00169" "80301" "ENSG00000241839" "PLEKHO2" "hsa:80301; Q7L4H4; Q8TD55; Q8WYS8" "Neutrophil degranulation" "" "1" "0" "1.000" "0.949" "0.970" "0.965" "0.959" "1.037" "1.076" "1.059" "0.987" "1218.9" "1219.2" "1156.6" "1182.6" "1176.4" "1169.2" "1264.1" "1310.9" "1290.2" "1202.7" "" "" "" "" "" "" "" "" "" "" "1080.9" "1009.9" "1009.2" "884.4" "981.0" "1074.0" "1068.4" "1083.6" "1183.3" "1202.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7842510788255330312" "False" "High" "IsMasterProtein" "O75896" "Tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=TUSC2 PE=1 SV=3" "0.000" "False" "35.781" "55" "3" "5" "3" "110" "12.1" "9.69" "31.53" "3" "cell cycle OR cell proliferation;stress response;transport;other biological processes" "mitochondrion" "" "Pf15000" "11334" "ENSG00000114383" "TUSC2" "B2R4Y9; hsa:11334; O75896" "" "" "0" "0" "1.092" "1.107" "1.050" "1.027" "1.064" "1.074" "1.013" "1.092" "0.688" "441.6" "482.4" "489.0" "463.8" "453.5" "470.0" "474.1" "447.2" "482.3" "303.6" "" "" "" "" "" "" "" "" "" "" "391.6" "399.6" "426.6" "346.9" "378.1" "431.8" "400.7" "369.6" "442.3" "303.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "35.750" "39" "10" "14" "10" "211" "24.2" "11.65" "44.70" "10" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.052" "1.019" "1.137" "1.052" "1.119" "1.051" "1.105" "1.090" "0.741" "2211.4" "2327.3" "2252.7" "2513.7" "2327.0" "2474.7" "2324.9" "2444.5" "2409.9" "1637.8" "" "" "" "" "" "" "" "" "" "" "1961.0" "1927.8" "1965.6" "1879.9" "1940.4" "2273.3" "1964.9" "2020.5" "2210.2" "1637.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1820553366353762966" "False" "High" "IsMasterProtein" "Q9UKF7" "Cytoplasmic phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNC1 PE=1 SV=3" "0.000" "False" "35.745" "21" "7" "9" "7" "332" "38.4" "6.40" "34.72" "7" "cell organization and biogenesis;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "26207" "ENSG00000154217" "PITPNC1" "A8K473; hsa:26207; J3QR20; Q96I07; Q9UKF7" "" "" "0" "0" "0.976" "0.981" "0.959" "0.960" "0.882" "1.003" "1.033" "0.970" "1.075" "1232.4" "1202.3" "1209.0" "1181.5" "1182.8" "1086.8" "1235.7" "1272.7" "1195.1" "1324.2" "" "" "" "" "" "" "" "" "" "" "1092.8" "995.9" "1054.9" "883.6" "986.3" "998.4" "1044.4" "1052.0" "1096.0" "1324.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "35.677" "26" "9" "10" "9" "339" "40.2" "6.83" "35.18" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "mRNA Splicing - Major Pathway" "" "1" "0" "1.097" "1.258" "1.223" "1.111" "0.897" "0.967" "1.022" "1.095" "2.832" "311.1" "341.2" "391.3" "380.5" "345.7" "278.9" "300.7" "318.1" "340.6" "880.9" "" "" "" "" "" "" "" "" "" "" "275.9" "282.6" "341.4" "284.5" "288.3" "256.2" "254.2" "262.9" "312.4" "880.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527678404860705700" "False" "High" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "0.000" "False" "35.675" "22" "10" "10" "10" "471" "51.5" "5.73" "28.81" "10" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "0" "0.908" "0.890" "0.944" "0.926" "0.880" "0.884" "0.965" "1.023" "0.567" "848.5" "770.9" "755.2" "800.9" "785.8" "746.6" "750.0" "818.5" "867.9" "480.7" "" "" "" "" "" "" "" "" "" "" "752.5" "638.5" "658.9" "598.9" "655.2" "685.8" "633.8" "676.6" "796.0" "480.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.000" "False" "35.668" "10" "8" "8" "8" "816" "91.3" "6.25" "28.13" "8" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "Synthesis of PIPs at the Golgi membrane" "" "1" "0" "0.976" "0.951" "1.045" "0.992" "0.910" "1.022" "1.039" "1.030" "0.963" "489.4" "477.7" "465.4" "511.6" "485.5" "445.4" "500.0" "508.4" "504.1" "471.3" "" "" "" "" "" "" "" "" "" "" "434.0" "395.7" "406.1" "382.6" "404.8" "409.2" "422.6" "420.2" "462.4" "471.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.000" "False" "35.665" "41" "8" "14" "8" "187" "21.4" "7.42" "44.27" "8" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "9" "0" "1.074" "0.989" "1.100" "1.025" "1.068" "1.131" "0.465" "1.054" "11.723" "414.3" "444.8" "409.5" "455.8" "424.7" "442.5" "468.5" "192.8" "436.6" "4856.7" "" "" "" "" "" "" "" "" "" "" "367.4" "368.4" "357.3" "340.9" "354.1" "406.5" "396.0" "159.4" "400.4" "4856.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696690186535498755" "False" "High" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "0.000" "False" "35.611" "38" "4" "7" "4" "140" "15.0" "9.14" "31.26" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.020" "1.048" "1.026" "0.985" "0.963" "1.126" "1.082" "0.976" "0.482" "1058.0" "1078.8" "1109.3" "1085.5" "1042.4" "1019.0" "1190.8" "1144.9" "1033.0" "509.9" "" "" "" "" "" "" "" "" "" "" "938.2" "893.6" "967.9" "811.8" "869.3" "936.1" "1006.4" "946.4" "947.4" "509.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695950193153579401" "False" "High" "IsMasterProtein" "Q6VEQ5" "WAS protein family homolog 2 OS=Homo sapiens OX=9606 GN=WASH2P PE=2 SV=2" "0.000" "False" "35.587" "13" "6" "8" "1" "465" "50.3" "5.71" "33.46" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH2P" "Q6VEQ5" "" "" "0" "4" "1.034" "1.024" "1.070" "1.050" "0.985" "1.069" "1.030" "1.062" "1.603" "1004.4" "1038.9" "1028.7" "1074.5" "1054.3" "989.3" "1073.9" "1034.2" "1066.5" "1610.0" "" "" "" "" "" "" "" "" "" "" "890.7" "860.6" "897.6" "803.5" "879.2" "908.8" "907.6" "854.9" "978.1" "1610.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "35.571" "24" "8" "10" "8" "361" "40.8" "5.25" "33.22" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "0.975" "0.931" "0.943" "0.913" "0.871" "0.898" "0.785" "0.978" "3.224" "829.9" "809.2" "772.2" "782.9" "757.6" "722.9" "745.2" "651.3" "811.9" "2675.3" "" "" "" "" "" "" "" "" "" "" "735.9" "670.3" "673.8" "585.5" "631.7" "664.1" "629.8" "538.4" "744.7" "2675.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "35.567" "24" "6" "7" "6" "354" "39.1" "6.44" "31.40" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "1.030" "0.991" "1.178" "1.080" "1.032" "1.616" "1.421" "1.408" "1.687" "488.1" "502.8" "483.7" "575.0" "527.3" "503.9" "788.9" "693.6" "687.4" "823.6" "" "" "" "" "" "" "" "" "" "" "432.8" "416.5" "422.1" "430.1" "439.7" "462.9" "666.7" "573.3" "630.4" "823.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5269036548224773448" "False" "High" "IsMasterProtein" "Q6UXH1" "Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1" "0.000" "False" "35.562" "17" "6" "10" "6" "353" "38.2" "4.59" "33.51" "6" "" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf07645" "79174" "ENSG00000184164" "CRELD2" "A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6; hsa:79174; Q4W0V0; Q6UXH1; Q86UC0; Q9BU47" "" "" "0" "0" "1.043" "0.994" "0.992" "1.033" "0.995" "1.088" "1.094" "1.081" "0.665" "1388.9" "1448.5" "1379.9" "1377.3" "1435.2" "1381.7" "1510.9" "1519.2" "1501.4" "923.3" "" "" "" "" "" "" "" "" "" "" "1231.6" "1199.9" "1204.1" "1030.1" "1196.7" "1269.3" "1276.9" "1255.8" "1376.9" "923.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.000" "False" "35.555" "14" "9" "11" "9" "640" "70.7" "7.62" "37.92" "9" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Gluconeogenesis" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "7" "0" "1.023" "1.048" "1.255" "1.048" "0.976" "1.175" "0.944" "1.137" "1.175" "240.7" "246.4" "252.3" "302.1" "252.3" "235.0" "283.0" "227.4" "273.8" "282.9" "" "" "" "" "" "" "" "" "" "" "213.5" "204.1" "220.2" "226.0" "210.4" "215.9" "239.2" "187.9" "251.1" "282.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6212598245542673461" "False" "High" "IsMasterProtein" "Q92879" "CUGBP Elav-like family member 1 OS=Homo sapiens OX=9606 GN=CELF1 PE=1 SV=2" "0.000" "False" "35.551" "15" "8" "10" "8" "486" "52.0" "8.46" "33.06" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10658" "ENSG00000149187" "CELF1" "B4E2U5; D3DQS0; F8W940; Q4LE52; Q92879; Q9NP83; Q9NR06" "" "Adipogenesis; mRNA processing" "2" "0" "1.051" "0.958" "1.161" "0.994" "1.254" "1.010" "0.387" "1.054" "10.804" "532.4" "559.4" "509.8" "618.2" "529.0" "667.7" "537.5" "206.2" "561.2" "5752.0" "" "" "" "" "" "" "" "" "" "" "472.1" "463.4" "444.9" "462.3" "441.1" "613.3" "454.3" "170.4" "514.7" "5752.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2069331310574252297" "False" "High" "IsMasterProtein" "O43708" "Maleylacetoacetate isomerase OS=Homo sapiens OX=9606 GN=GSTZ1 PE=1 SV=3" "0.000" "False" "35.480" "28" "7" "10" "7" "216" "24.2" "8.54" "35.53" "7" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf13409, Pf14497" "2954" "ENSG00000100577" "GSTZ1" "A6NED0; A6NNB8; A8MWD7; B2RCK3; hsa:2954; O15308; O43708; O75430; Q6IB17; Q7Z610; Q9BV63" "Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism" "Metapathway biotransformation Phase I and II" "4" "0" "1.010" "1.056" "0.993" "1.062" "1.103" "1.025" "1.102" "1.049" "0.660" "1509.3" "1524.7" "1593.1" "1499.2" "1602.5" "1665.0" "1546.6" "1662.9" "1583.7" "996.9" "" "" "" "" "" "" "" "" "" "" "1338.4" "1263.0" "1390.1" "1121.2" "1336.3" "1529.5" "1307.1" "1374.5" "1452.5" "996.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.000" "False" "35.442" "15" "8" "10" "8" "521" "56.7" "7.99" "32.36" "8" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; COPI-mediated anterograde transport" "IL-18 signaling pathway; 5q35 copy number variation" "5" "0" "1.001" "0.920" "0.910" "0.894" "0.761" "0.803" "0.694" "0.930" "2.800" "253.1" "253.2" "232.8" "230.2" "226.3" "192.5" "203.2" "175.6" "235.4" "708.6" "" "" "" "" "" "" "" "" "" "" "224.4" "209.8" "203.1" "172.2" "188.7" "176.8" "171.7" "145.1" "215.9" "708.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1759740052719989179" "False" "High" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "0.000" "False" "35.400" "19" "3" "16" "3" "156" "17.4" "4.93" "54.25" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; O14561; Q9UNV1" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "0.934" "0.982" "0.891" "0.950" "0.967" "0.901" "0.972" "1.002" "0.396" "2266.6" "2116.2" "2226.5" "2018.9" "2154.1" "2192.2" "2041.4" "2203.0" "2270.6" "898.3" "" "" "" "" "" "" "" "" "" "" "2010.0" "1753.0" "1942.7" "1509.8" "1796.2" "2013.8" "1725.3" "1820.9" "2082.4" "898.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327497704722334246" "False" "High" "IsMasterProtein" "Q14894" "Ketimine reductase mu-crystallin OS=Homo sapiens OX=9606 GN=CRYM PE=1 SV=1" "0.000" "False" "35.393" "26" "7" "8" "7" "314" "33.8" "5.14" "32.12" "7" "other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02423" "1428" "ENSG00000103316" "CRYM" "D5MNX0; hsa:1428; Q14894; Q5HYB7" "Lysine catabolism" "" "1" "0" "1.147" "0.968" "1.083" "1.074" "1.080" "1.005" "0.970" "0.966" "0.578" "438.3" "502.5" "424.2" "474.6" "470.8" "473.6" "440.4" "425.3" "423.2" "253.4" "" "" "" "" "" "" "" "" "" "" "388.7" "416.3" "370.2" "354.9" "392.6" "435.0" "372.2" "351.6" "388.1" "253.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.000" "False" "35.379" "43" "4" "11" "4" "116" "13.2" "5.00" "50.18" "4" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "1.084" "1.003" "1.210" "1.106" "1.118" "1.155" "1.044" "1.092" "0.647" "429.5" "465.5" "430.8" "519.9" "475.1" "480.1" "496.1" "448.4" "468.9" "277.7" "" "" "" "" "" "" "" "" "" "" "380.9" "385.6" "375.9" "388.8" "396.2" "441.0" "419.3" "370.6" "430.0" "277.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5974155710491899055" "False" "High" "IsMasterProtein" "Q9UHD2" "Serine/threonine-protein kinase TBK1 OS=Homo sapiens OX=9606 GN=TBK1 PE=1 SV=1" "0.000" "False" "35.338" "14" "8" "8" "8" "729" "83.6" "6.79" "27.60" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf18394, Pf18396" "29110" "ENSG00000183735" "TBK1" "A8K4S4; hsa:29110; Q8IYV3; Q9NUJ5; Q9UHD2" "IRF3-mediated induction of type I IFN; Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TNFR1-induced proapoptotic signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Interleukin-37 signaling; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN" "TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Toll-like receptor signaling pathway" "35" "0" "1.217" "1.063" "1.246" "0.983" "1.088" "1.168" "0.105" "1.024" "17.015" "185.5" "225.7" "197.2" "231.2" "182.4" "201.9" "216.6" "19.5" "189.9" "3156.7" "" "" "" "" "" "" "" "" "" "" "164.5" "187.0" "172.1" "172.9" "152.1" "185.4" "183.1" "16.1" "174.2" "3156.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "307320246962858459" "False" "High" "IsMasterProtein" "Q6UWZ7" "BRCA1-A complex subunit Abraxas 1 OS=Homo sapiens OX=9606 GN=ABRAXAS1 PE=1 SV=2" "0.000" "False" "35.310" "19" "8" "9" "8" "409" "46.6" "7.05" "33.54" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "cytoskeletal activity;other molecular function" "Pf21125" "84142" "ENSG00000163322" "ABRAXAS1" "A5JJ07; hsa:84142; Q6UWZ7; Q9H8I1; Q9H9N4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "0.996" "0.990" "1.054" "1.050" "0.952" "0.947" "1.013" "0.975" "0.703" "1025.0" "1020.7" "1014.2" "1079.8" "1076.3" "975.3" "970.5" "1038.0" "999.0" "720.4" "" "" "" "" "" "" "" "" "" "" "908.9" "845.5" "884.9" "807.6" "897.5" "895.9" "820.2" "858.0" "916.2" "720.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "35.288" "21" "5" "7" "5" "262" "29.3" "9.79" "29.64" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "Mitochondrial translation termination" "" "1" "0" "0.992" "0.962" "1.073" "0.957" "1.038" "0.920" "0.903" "0.912" "1.071" "1094.6" "1086.3" "1052.7" "1174.4" "1047.1" "1136.3" "1006.7" "988.1" "998.3" "1172.2" "" "" "" "" "" "" "" "" "" "" "970.6" "899.8" "918.5" "878.3" "873.1" "1043.8" "850.8" "816.7" "915.6" "1172.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "35.257" "15" "9" "10" "9" "658" "73.8" "6.33" "37.02" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "0.966" "1.030" "1.054" "1.116" "0.967" "1.067" "1.019" "1.009" "0.843" "550.0" "531.4" "566.8" "579.5" "613.9" "531.8" "586.7" "560.3" "555.1" "463.9" "" "" "" "" "" "" "" "" "" "" "487.7" "440.2" "494.6" "433.4" "511.9" "488.6" "495.8" "463.1" "509.1" "463.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "35.186" "39" "7" "7" "7" "251" "28.0" "6.71" "32.30" "7" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "1.011" "0.924" "1.053" "1.019" "1.066" "0.929" "1.019" "0.846" "0.518" "676.8" "684.3" "625.4" "712.5" "689.4" "721.6" "628.9" "689.4" "572.8" "350.9" "" "" "" "" "" "" "" "" "" "" "600.2" "566.8" "545.7" "532.8" "574.9" "662.8" "531.5" "569.8" "525.4" "350.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.000" "False" "35.125" "25" "5" "13" "5" "191" "20.9" "4.39" "35.85" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "1.139" "0.989" "1.007" "1.019" "1.008" "0.978" "0.951" "1.020" "0.753" "1005.7" "1145.2" "995.2" "1012.6" "1025.3" "1013.3" "983.4" "956.7" "1025.6" "757.6" "" "" "" "" "" "" "" "" "" "" "891.9" "948.6" "868.3" "757.3" "855.0" "930.8" "831.2" "790.8" "940.6" "757.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2142775620520920710" "False" "High" "IsMasterProtein" "P15559" "NAD(P)H dehydrogenase [quinone] 1 OS=Homo sapiens OX=9606 GN=NQO1 PE=1 SV=1" "0.000" "False" "35.071" "26" "7" "10" "7" "274" "30.8" "8.88" "35.40" "7" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02525" "1728" "ENSG00000181019" "NQO1" "B2R5Y9; B4DNM7; B7ZAD1; hsa:1728; P15559; Q86UK1" "Regulation of ornithine decarboxylase (ODC); NFE2L2 regulating anti-oxidant/detoxification enzymes" "Dopamine metabolism; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Interactions between LOXL4 and oxidative stress pathway; Benzene metabolism; Oxidative stress response; NRF2-ARE regulation; Male infertility; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Estrogen metabolism" "17" "0" "0.972" "0.872" "0.810" "0.789" "0.768" "0.764" "0.863" "0.934" "1.009" "591.2" "574.9" "515.6" "478.7" "466.7" "454.3" "451.6" "510.3" "552.0" "596.4" "" "" "" "" "" "" "" "" "" "" "524.3" "476.3" "449.9" "358.0" "389.2" "417.3" "381.7" "421.8" "506.3" "596.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.000" "False" "35.010" "9" "6" "8" "6" "925" "100.5" "5.80" "27.64" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "1.138" "1.160" "1.275" "1.096" "0.698" "0.914" "0.477" "0.740" "8.824" "88.7" "101.0" "102.9" "113.1" "97.2" "61.9" "81.1" "42.3" "65.6" "782.8" "" "" "" "" "" "" "" "" "" "" "78.7" "83.7" "89.8" "84.6" "81.1" "56.8" "68.6" "34.9" "60.2" "782.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6950244637905263726" "False" "High" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "0.000" "False" "34.951" "28" "3" "7" "3" "125" "14.6" "9.38" "28.78" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "0.931" "0.962" "0.901" "0.909" "0.871" "0.885" "0.848" "0.927" "1.957" "1559.9" "1452.0" "1500.4" "1405.6" "1418.2" "1358.4" "1379.8" "1322.3" "1446.8" "3052.1" "" "" "" "" "" "" "" "" "" "" "1383.3" "1202.8" "1309.1" "1051.2" "1182.5" "1247.9" "1166.1" "1093.0" "1326.9" "3052.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "34.941" "17" "6" "8" "6" "360" "41.1" "6.64" "31.06" "6" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "snRNP Assembly" "" "1" "0" "1.035" "0.995" "0.953" "0.920" "0.997" "0.818" "0.803" "0.845" "1.829" "902.8" "934.1" "898.3" "860.4" "830.7" "899.9" "738.4" "725.2" "763.2" "1651.2" "" "" "" "" "" "" "" "" "" "" "800.6" "773.8" "783.8" "643.5" "692.7" "826.6" "624.1" "599.4" "700.0" "1651.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740975055967109676" "False" "High" "IsMasterProtein" "O95926" "Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1" "0.000" "False" "34.939" "28" "6" "8" "6" "243" "28.7" "8.40" "29.12" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf08231" "25949" "ENSG00000117614" "SYF2" "hsa:25949; O95926; Q5TH73" "mRNA Splicing - Major Pathway" "" "1" "0" "0.945" "0.961" "0.975" "0.958" "0.940" "0.887" "0.912" "0.921" "0.534" "1214.8" "1148.1" "1167.6" "1185.0" "1163.6" "1141.4" "1077.8" "1108.0" "1119.1" "648.8" "" "" "" "" "" "" "" "" "" "" "1077.3" "951.1" "1018.7" "886.3" "970.3" "1048.5" "910.9" "915.8" "1026.4" "648.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.000" "False" "34.917" "76" "4" "7" "4" "100" "10.9" "4.27" "42.51" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "1.023" "0.959" "1.087" "0.996" "0.966" "1.082" "1.066" "1.143" "0.741" "629.4" "643.9" "603.4" "684.1" "626.8" "608.3" "681.1" "670.9" "719.7" "466.5" "" "" "" "" "" "" "" "" "" "" "558.1" "533.4" "526.5" "511.6" "522.6" "558.8" "575.6" "554.5" "660.1" "466.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8011732413234136033" "False" "High" "IsMasterProtein" "Q9UJX4" "Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2" "0.000" "False" "34.894" "11" "8" "8" "8" "755" "85.0" "6.87" "28.53" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf12862, Pf21371" "51433" "ENSG00000089053" "ANAPC5" "E9PFB2; hsa:51433; Q8N4H7; Q9BQD4; Q9UJX4" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.025" "0.950" "1.104" "1.043" "0.918" "1.030" "0.952" "0.961" "1.487" "503.5" "515.9" "478.5" "555.9" "524.9" "462.2" "518.8" "479.3" "483.7" "748.6" "" "" "" "" "" "" "" "" "" "" "446.5" "427.3" "417.5" "415.8" "437.7" "424.6" "438.4" "396.1" "443.6" "748.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5609078604117945067" "False" "High" "IsMasterProtein" "Q9H777" "Zinc phosphodiesterase ELAC protein 1 OS=Homo sapiens OX=9606 GN=ELAC1 PE=1 SV=2" "0.000" "False" "34.869" "20" "6" "7" "6" "363" "40.0" "6.79" "26.48" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00753" "55520" "ENSG00000141642" "ELAC1" "hsa:55520; Q9H777; Q9NS99" "" "" "0" "0" "0.989" "1.015" "1.018" "0.969" "1.050" "0.966" "0.991" "0.965" "0.605" "609.1" "602.6" "618.6" "620.2" "590.2" "639.7" "588.7" "603.6" "587.9" "368.5" "" "" "" "" "" "" "" "" "" "" "540.2" "499.1" "539.7" "463.9" "492.2" "587.7" "497.6" "498.9" "539.2" "368.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "34.848" "19" "6" "9" "6" "351" "38.7" "6.09" "34.81" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.087" "1.090" "0.976" "1.041" "1.080" "1.074" "1.012" "1.012" "0.939" "673.2" "732.1" "733.8" "657.3" "700.6" "727.2" "723.3" "681.5" "681.0" "632.3" "" "" "" "" "" "" "" "" "" "" "597.0" "606.4" "640.2" "491.6" "584.2" "668.0" "611.3" "563.3" "624.6" "632.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657158777638447925" "False" "High" "IsMasterProtein" "P20273" "B-cell receptor CD22 OS=Homo sapiens OX=9606 GN=CD22 PE=1 SV=2" "0.000" "False" "34.831" "11" "7" "7" "7" "847" "95.3" "6.65" "23.80" "7" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08205, Pf13895, Pf13927" "933" "ENSG00000012124" "CD22" "F5GYU4; F5H7U3; hsa:933; O95699; O95701; O95702; O95703; P20273; Q01665; Q32M46; Q92872; Q92873; Q9UQA6; Q9UQA7; Q9UQA8; Q9UQA9; Q9UQB0; Q9Y2A6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CD22 mediated BCR regulation" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "0.893" "0.838" "1.054" "0.929" "0.820" "0.953" "0.875" "0.899" "0.638" "1141.9" "1019.7" "957.0" "1203.6" "1061.4" "935.8" "1088.7" "999.0" "1026.4" "728.3" "" "" "" "" "" "" "" "" "" "" "1012.6" "844.7" "835.0" "900.2" "885.0" "859.6" "920.1" "825.8" "941.4" "728.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "34.815" "15" "6" "7" "6" "414" "44.7" "6.25" "25.42" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "8" "0" "0.990" "0.935" "0.939" "0.892" "0.951" "0.852" "0.804" "0.846" "1.714" "606.6" "600.6" "567.0" "569.7" "541.3" "577.2" "516.9" "488.0" "513.2" "1039.5" "" "" "" "" "" "" "" "" "" "" "538.0" "497.5" "494.7" "426.0" "451.4" "530.2" "436.9" "403.4" "470.6" "1039.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4966290939603233061" "False" "High" "IsMasterProtein" "O00461" "Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1" "0.000" "False" "34.773" "12" "8" "16" "8" "696" "81.8" "4.77" "40.90" "8" "" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "27333" "ENSG00000173905" "GOLIM4" "hsa:27333; O00461" "Intra-Golgi traffic" "" "1" "0" "1.005" "0.970" "1.080" "1.027" "1.053" "1.083" "1.143" "1.099" "0.695" "320.9" "322.7" "311.3" "346.5" "329.4" "338.1" "347.4" "366.8" "352.6" "222.9" "" "" "" "" "" "" "" "" "" "" "284.6" "267.3" "271.6" "259.1" "274.7" "310.6" "293.6" "303.2" "323.4" "222.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8342243932904844919" "False" "High" "IsMasterProtein" "Q13555" "Calcium/calmodulin-dependent protein kinase type II subunit gamma OS=Homo sapiens OX=9606 GN=CAMK2G PE=1 SV=4" "0.000" "False" "34.771" "11" "6" "8" "3" "558" "62.6" "7.83" "29.83" "6" "cell-cell signaling;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08332" "818" "ENSG00000148660" "CAMK2G" "A0A0A0MS52; A0A0A0MT11; hsa:818; O00561; O15378; Q13279; Q13282; Q13555; Q13556; Q5SQZ3; Q5SQZ4; Q5SWX4; Q7KYX5; Q8N4I3; Q8NIA4" "RAF activation; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Signaling by BRAF and RAF1 fusions; Interferon gamma signaling; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway" "31" "0" "0.823" "0.884" "0.813" "0.823" "0.995" "0.955" "0.837" "0.917" "2.332" "410.7" "338.0" "363.2" "334.1" "338.1" "408.7" "392.4" "343.6" "376.5" "957.5" "" "" "" "" "" "" "" "" "" "" "364.2" "280.0" "316.9" "249.8" "281.9" "375.4" "331.6" "284.0" "345.3" "957.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "High" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.000" "False" "34.766" "17" "4" "7" "4" "271" "28.8" "5.83" "27.23" "4" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis" "2" "0" "1.082" "0.975" "1.179" "1.137" "1.037" "1.239" "1.210" "0.988" "1.181" "530.4" "574.1" "517.3" "625.5" "603.2" "549.8" "657.4" "642.0" "524.1" "626.7" "" "" "" "" "" "" "" "" "" "" "470.4" "475.5" "451.3" "467.8" "503.0" "505.1" "555.6" "530.6" "480.7" "626.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "34.763" "42" "10" "14" "10" "194" "22.6" "10.65" "45.73" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "1.083" "1.061" "1.178" "1.182" "0.925" "0.992" "0.961" "1.035" "2.036" "1204.1" "1304.3" "1276.9" "1418.7" "1422.9" "1113.8" "1194.4" "1157.3" "1245.7" "2451.8" "" "" "" "" "" "" "" "" "" "" "1067.8" "1080.4" "1114.2" "1061.0" "1186.5" "1023.1" "1009.5" "956.6" "1142.5" "2451.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128551820349889228" "False" "High" "IsMasterProtein" "P51531" "Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2" "0.000" "False" "34.735" "6" "9" "9" "3" "1590" "181.2" "7.20" "25.38" "9" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6595" "ENSG00000080503" "SMARCA2" "B1ALG3; B1ALG4; D3DRH4; D3DRH5; hsa:6595; P51531" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "Retinoblastoma gene in cancer; Pathways affected in adenoid cystic carcinoma; VEGFA-VEGFR2 signaling; Rett syndrome; Thermogenesis; Kleefstra syndrome" "8" "0" "0.141" "0.111" "0.149" "0.175" "0.191" "0.213" "0.170" "0.161" "0.075" "102.5" "14.5" "11.3" "15.3" "17.9" "19.6" "21.8" "17.4" "16.5" "7.7" "" "" "" "" "" "" "" "" "" "" "90.9" "12.0" "9.9" "11.4" "14.9" "18.0" "18.4" "14.4" "15.1" "7.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "34.692" "9" "5" "5" "5" "781" "89.3" "5.99" "23.52" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "mRNA Splicing - Major Pathway" "" "1" "0" "0.988" "0.962" "0.979" "0.986" "0.936" "0.990" "1.075" "0.973" "0.465" "452.4" "447.2" "435.3" "442.7" "446.2" "423.5" "447.8" "486.2" "440.2" "210.4" "" "" "" "" "" "" "" "" "" "" "401.2" "370.4" "379.8" "331.1" "372.1" "389.0" "378.5" "401.9" "403.7" "210.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625038226073765913" "False" "High" "IsMasterProtein" "P61421" "V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1" "0.000" "False" "34.687" "20" "7" "9" "7" "351" "40.3" "5.00" "32.18" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01992" "9114" "ENSG00000159720" "ATP6V0D1" "hsa:9114; P12953; P61421; Q02547" "Amino acids regulate mTORC1; XBP1(S) activates chaperone genes; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "VEGFA-VEGFR2 signaling" "7" "0" "1.076" "1.057" "1.036" "1.130" "1.146" "1.110" "0.947" "1.362" "4.475" "366.8" "394.6" "387.7" "380.2" "414.5" "420.2" "407.1" "347.3" "499.7" "1641.5" "" "" "" "" "" "" "" "" "" "" "325.3" "326.9" "338.3" "284.3" "345.6" "386.0" "344.0" "287.0" "458.3" "1641.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240995388596956577" "False" "High" "IsMasterProtein" "Q08379" "Golgin subfamily A member 2 OS=Homo sapiens OX=9606 GN=GOLGA2 PE=1 SV=3" "0.000" "False" "34.675" "7" "6" "7" "6" "1002" "113.0" "5.02" "26.22" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf15070, Pf19046" "2801" "ENSG00000167110" "GOLGA2" "A0A0C4DGS5; hsa:2801; Q08379; Q6GRM9; Q9BRB0; Q9NYF9" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Golgi Cisternae Pericentriolar Stack Reorganization" "" "4" "0" "1.006" "0.926" "0.968" "0.912" "0.958" "0.935" "0.776" "0.931" "2.244" "359.4" "361.4" "332.8" "347.7" "327.9" "344.2" "335.8" "279.0" "334.6" "806.3" "" "" "" "" "" "" "" "" "" "" "318.7" "299.4" "290.4" "260.0" "273.4" "316.2" "283.8" "230.6" "306.9" "806.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "34.616" "36" "9" "13" "9" "226" "26.5" "5.88" "44.26" "9" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "0.909" "0.926" "0.968" "0.978" "0.986" "1.120" "1.044" "1.135" "1.225" "1460.2" "1328.0" "1351.7" "1413.1" "1428.1" "1440.3" "1635.8" "1524.7" "1657.3" "1788.8" "" "" "" "" "" "" "" "" "" "" "1294.8" "1100.0" "1179.4" "1056.8" "1190.9" "1323.0" "1382.5" "1260.2" "1520.0" "1788.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "34.612" "40" "6" "11" "6" "161" "18.1" "6.79" "40.74" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.009" "0.952" "1.156" "1.038" "1.006" "1.045" "0.990" "0.956" "3.108" "386.7" "390.3" "368.2" "447.0" "401.4" "388.9" "404.2" "382.8" "369.9" "1201.9" "" "" "" "" "" "" "" "" "" "" "343.0" "323.3" "321.3" "334.3" "334.7" "357.2" "341.6" "316.4" "339.2" "1201.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3386437626543326564" "False" "High" "IsMasterProtein" "Q9BWE0" "DNA-binding protein REPIN1 OS=Homo sapiens OX=9606 GN=REPIN1 PE=1 SV=1" "0.000" "False" "34.588" "15" "8" "10" "8" "567" "63.5" "9.98" "37.22" "8" "DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "29803" "ENSG00000214022" "REPIN1" "C9J3L7; D3DWZ1; hsa:29803; Q7LE03; Q9BUZ6; Q9BWE0; Q9NZH2; Q9UMP5" "" "" "0" "0" "0.925" "0.898" "0.985" "0.787" "0.820" "0.859" "0.995" "1.058" "0.635" "481.9" "445.9" "432.9" "474.6" "379.1" "395.3" "413.9" "479.8" "510.0" "306.1" "" "" "" "" "" "" "" "" "" "" "427.4" "369.4" "377.8" "355.0" "316.1" "363.1" "349.8" "396.6" "467.7" "306.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8005883181375695291" "False" "High" "IsMasterProtein" "Q9P260" "RAB11-binding protein RELCH OS=Homo sapiens OX=9606 GN=RELCH PE=1 SV=2" "0.000" "False" "34.572" "6" "7" "9" "7" "1216" "134.5" "5.45" "30.67" "7" "transport" "ER/Golgi;other cytoplasmic organelle" "" "" "57614" "ENSG00000134444" "RELCH" "hsa:57614; Q9P260" "" "" "0" "0" "0.926" "0.968" "0.986" "0.942" "0.821" "0.903" "0.861" "0.911" "1.847" "311.0" "287.9" "301.2" "306.8" "292.9" "255.3" "280.9" "267.8" "283.5" "574.4" "" "" "" "" "" "" "" "" "" "" "275.8" "238.5" "262.8" "229.4" "244.3" "234.5" "237.4" "221.4" "260.0" "574.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4618404774181820652" "False" "High" "IsMasterProtein" "P57076" "Cilia- and flagella-associated protein 298 OS=Homo sapiens OX=9606 GN=CFAP298 PE=1 SV=1" "0.000" "False" "34.538" "16" "3" "4" "3" "290" "33.2" "7.44" "21.97" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf11069" "56683" "ENSG00000159079" "CFAP298" "hsa:56683; P57076; Q53FH0" "" "Ciliopathies" "1" "0" "1.057" "0.918" "0.931" "1.012" "1.118" "0.943" "0.456" "0.951" "9.327" "276.6" "292.3" "253.9" "257.5" "279.9" "309.3" "260.9" "126.2" "263.0" "2579.4" "" "" "" "" "" "" "" "" "" "" "245.2" "242.2" "221.6" "192.6" "233.4" "284.1" "220.5" "104.3" "241.2" "2579.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.000" "False" "34.488" "6" "9" "9" "9" "1411" "151.1" "8.03" "29.55" "9" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "0.967" "0.893" "0.928" "0.870" "0.986" "0.832" "0.833" "0.819" "1.056" "671.1" "649.2" "599.0" "622.7" "583.8" "661.4" "558.2" "559.3" "549.9" "708.6" "" "" "" "" "" "" "" "" "" "" "595.1" "537.7" "522.7" "465.7" "486.8" "607.6" "471.8" "462.3" "504.3" "708.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7768622532908684431" "False" "High" "IsMasterProtein" "P26842" "CD27 antigen OS=Homo sapiens OX=9606 GN=CD27 PE=1 SV=2" "0.000" "False" "34.462" "18" "4" "8" "4" "260" "29.1" "7.64" "30.23" "4" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf00020" "939" "ENSG00000139193" "CD27" "B2RDZ0; hsa:939; P26842" "TNFs bind their physiological receptors" "" "1" "0" "1.004" "0.964" "1.034" "0.924" "1.000" "0.857" "0.856" "0.879" "0.400" "400.7" "402.3" "386.2" "414.3" "370.2" "400.5" "343.2" "343.1" "352.4" "160.4" "" "" "" "" "" "" "" "" "" "" "355.3" "333.3" "337.0" "309.8" "308.7" "367.9" "290.1" "283.6" "323.2" "160.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "34.335" "24" "8" "13" "8" "331" "36.9" "5.03" "44.03" "8" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "2" "0" "1.039" "1.022" "1.071" "1.073" "1.040" "1.087" "1.082" "0.978" "1.863" "854.2" "887.3" "873.1" "914.5" "916.4" "888.5" "928.2" "924.3" "835.7" "1591.3" "" "" "" "" "" "" "" "" "" "" "757.5" "735.0" "761.8" "684.0" "764.1" "816.2" "784.5" "764.0" "766.4" "1591.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "High" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.000" "False" "34.325" "34" "8" "9" "8" "259" "29.8" "7.68" "31.60" "8" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "1.006" "1.029" "1.061" "1.066" "0.966" "1.152" "1.094" "1.038" "0.751" "232.8" "234.2" "239.5" "247.0" "248.2" "224.9" "268.2" "254.6" "241.6" "174.8" "" "" "" "" "" "" "" "" "" "" "206.4" "194.0" "209.0" "184.7" "207.0" "206.6" "226.7" "210.4" "221.6" "174.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "34.325" "57" "5" "8" "5" "76" "8.8" "5.48" "30.88" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "5q35 copy number variation" "3" "0" "0.926" "0.964" "0.943" "0.920" "1.006" "0.952" "1.027" "0.988" "0.399" "1396.3" "1293.6" "1346.0" "1316.6" "1284.0" "1405.3" "1329.4" "1434.6" "1380.1" "557.7" "" "" "" "" "" "" "" "" "" "" "1238.2" "1071.6" "1174.5" "984.6" "1070.6" "1290.9" "1123.6" "1185.8" "1265.8" "557.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "34.294" "36" "6" "10" "4" "162" "18.9" "8.44" "35.73" "6" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "0" "1.002" "1.022" "1.031" "1.029" "1.011" "1.103" "0.990" "1.007" "1.625" "864.3" "866.0" "883.3" "890.8" "889.0" "873.6" "953.8" "855.3" "870.0" "1404.9" "" "" "" "" "" "" "" "" "" "" "766.5" "717.3" "770.7" "666.2" "741.3" "802.5" "806.1" "707.0" "797.9" "1404.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "High" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.000" "False" "34.284" "35" "5" "8" "5" "142" "16.8" "5.85" "29.60" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.992" "0.963" "0.920" "1.080" "1.060" "1.086" "1.099" "0.998" "0.408" "1152.7" "1143.1" "1110.0" "1060.7" "1244.8" "1222.1" "1251.9" "1266.7" "1150.7" "470.6" "" "" "" "" "" "" "" "" "" "" "1022.2" "946.9" "968.6" "793.2" "1038.0" "1122.6" "1058.0" "1047.0" "1055.3" "470.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-466153880284673871" "False" "High" "IsMasterProtein" "Q12873" "Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3" "0.000" "False" "34.247" "3" "6" "7" "3" "2000" "226.5" "7.30" "27.27" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1107" "ENSG00000170004" "CHD3" "D3DTQ9; E9PG89; hsa:1107; Q12873; Q9Y4I0" "Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in progeria" "8" "0" "0.953" "0.944" "0.962" "0.868" "1.106" "0.789" "0.483" "1.054" "8.678" "160.5" "152.9" "151.4" "154.4" "139.4" "177.4" "126.6" "77.4" "169.1" "1392.5" "" "" "" "" "" "" "" "" "" "" "142.3" "126.7" "132.1" "115.4" "116.2" "163.0" "107.0" "64.0" "155.1" "1392.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3626479859969264661" "False" "High" "IsMasterProtein" "Q96QG7" "Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1" "0.000" "False" "34.240" "15" "7" "8" "7" "549" "63.4" "6.39" "28.14" "7" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf06602, Pf21098" "66036" "ENSG00000104643; ENSG00000285032" "MTMR9" "B7Z291; hsa:66036; Q52LU3; Q8WW11; Q96QG6; Q96QG7; Q9NX50" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "8p23.1 copy number variation syndrome" "4" "0" "1.019" "0.894" "1.022" "0.883" "0.875" "0.935" "0.894" "0.822" "1.181" "1038.8" "1058.5" "928.5" "1061.3" "917.6" "909.0" "971.6" "929.0" "854.1" "1226.9" "" "" "" "" "" "" "" "" "" "" "921.2" "876.8" "810.2" "793.7" "765.2" "835.0" "821.2" "767.8" "783.3" "1226.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1189012646270467424" "False" "High" "IsMasterProtein" "Q9H5Q4" "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" "0.000" "False" "34.204" "21" "9" "12" "9" "396" "45.3" "9.19" "38.97" "9" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00398" "64216" "ENSG00000162851" "TFB2M" "hsa:64216; Q9H5Q4; Q9H626" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Mitochondrial gene expression" "4" "0" "1.046" "1.040" "1.057" "1.051" "1.100" "0.971" "0.959" "0.982" "1.272" "716.9" "750.0" "745.6" "757.6" "753.4" "788.4" "696.0" "687.9" "703.9" "911.7" "" "" "" "" "" "" "" "" "" "" "635.7" "621.3" "650.5" "566.6" "628.2" "724.2" "588.2" "568.6" "645.6" "911.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7828842707520281021" "False" "High" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "0.000" "False" "34.197" "40" "6" "10" "6" "144" "17.0" "8.82" "37.73" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "mRNA Splicing - Major Pathway" "" "1" "0" "0.956" "0.954" "0.961" "0.976" "0.978" "0.918" "0.961" "0.982" "0.927" "1317.5" "1259.1" "1256.4" "1266.0" "1286.4" "1288.9" "1208.9" "1266.5" "1293.7" "1221.9" "" "" "" "" "" "" "" "" "" "" "1168.3" "1043.0" "1096.3" "946.8" "1072.7" "1184.0" "1021.7" "1046.9" "1186.5" "1221.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "837370257864581378" "False" "High" "IsMasterProtein" "Q01415" "N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1" "0.000" "False" "34.139" "22" "8" "8" "8" "458" "50.3" "6.61" "29.17" "8" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2585" "ENSG00000156958" "GALK2" "hsa:2585; Q01415; Q7Z4Q4" "" "" "0" "0" "0.892" "0.951" "1.001" "0.993" "0.942" "1.001" "1.026" "0.986" "0.639" "225.4" "201.1" "214.2" "225.6" "223.9" "212.4" "225.7" "231.2" "222.2" "144.1" "" "" "" "" "" "" "" "" "" "" "199.9" "166.6" "186.9" "168.7" "186.7" "195.1" "190.8" "191.1" "203.8" "144.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6964625045538099576" "False" "High" "IsMasterProtein" "Q9H6R7" "WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1" "0.000" "False" "34.134" "13" "7" "8" "7" "721" "79.1" "6.70" "25.27" "7" "cell organization and biogenesis" "" "other molecular function" "Pf15390" "80304" "ENSG00000163026" "WDCP" "D6W532; hsa:80304; Q8IYK0; Q9H6R7; Q9HBP5" "Signaling by ALK fusions and activated point mutants" "Mesodermal commitment pathway" "2" "0" "0.995" "0.932" "0.974" "0.952" "0.974" "0.941" "0.950" "0.999" "1.205" "873.0" "868.7" "813.9" "850.1" "831.4" "850.6" "821.5" "829.5" "872.3" "1052.4" "" "" "" "" "" "" "" "" "" "" "774.1" "719.6" "710.2" "635.8" "693.3" "781.4" "694.3" "685.6" "800.0" "1052.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2850205802309277585" "False" "High" "IsMasterProtein" "Q96DE0" "U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2" "0.000" "False" "34.117" "38" "7" "10" "6" "195" "21.3" "6.89" "37.29" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "131870" "ENSG00000198585" "NUDT16" "B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82" "Phosphate bond hydrolysis by NUDT proteins" "" "1" "1" "0.985" "0.928" "1.084" "1.068" "1.026" "1.040" "0.953" "0.901" "0.562" "484.5" "477.4" "449.6" "525.3" "517.4" "496.9" "503.9" "461.8" "436.4" "272.1" "" "" "" "" "" "" "" "" "" "" "429.6" "395.4" "392.3" "392.8" "431.4" "456.5" "425.9" "381.7" "400.2" "272.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.000" "False" "34.098" "29" "7" "13" "7" "261" "28.0" "8.05" "40.65" "7" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "2" "0" "0.873" "1.014" "1.018" "0.955" "0.840" "1.011" "0.987" "0.960" "0.734" "1195.5" "1043.5" "1211.8" "1216.7" "1141.6" "1003.7" "1208.3" "1180.4" "1147.4" "877.1" "" "" "" "" "" "" "" "" "" "" "1060.1" "864.3" "1057.3" "909.9" "952.0" "922.0" "1021.2" "975.7" "1052.3" "877.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2604748441743257015" "False" "High" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "0.000" "False" "34.062" "15" "8" "11" "8" "531" "60.5" "9.61" "33.25" "8" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Hedgehog 'on' state; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex" "Endoderm differentiation" "7" "0" "0.895" "0.921" "1.015" "0.946" "0.886" "0.966" "0.707" "0.931" "4.955" "250.3" "223.9" "230.6" "254.1" "236.8" "221.8" "241.8" "176.9" "232.9" "1240.1" "" "" "" "" "" "" "" "" "" "" "221.9" "185.5" "201.2" "190.0" "197.5" "203.7" "204.4" "146.2" "213.6" "1240.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4910055014827061803" "False" "High" "IsMasterProtein" "Q14653" "Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1" "0.000" "False" "33.983" "18" "6" "9" "6" "427" "47.2" "5.34" "32.41" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3661" "ENSG00000126456" "IRF3" "A8K7L2; B2RAZ3; hsa:3661; Q14653; Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6" "ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Interferon gamma signaling; Interferon alpha/beta signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; IRF3 mediated activation of type 1 IFN" "Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Fibrin complement receptor 3 signaling pathway; White fat cell differentiation; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Urotensin-II-mediated signaling pathway; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; Toll-like receptor signaling pathway" "38" "0" "1.145" "1.079" "1.215" "1.228" "1.094" "1.133" "1.058" "0.954" "1.146" "497.4" "569.3" "536.6" "604.5" "610.8" "544.0" "563.4" "526.2" "474.3" "570.1" "" "" "" "" "" "" "" "" "" "" "441.1" "471.6" "468.2" "452.1" "509.3" "499.8" "476.2" "435.0" "435.0" "570.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532813342924820659" "False" "High" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "0.000" "False" "33.978" "20" "8" "12" "5" "392" "46.5" "10.01" "42.87" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "3" "0.988" "0.894" "1.064" "0.935" "0.919" "0.950" "0.827" "0.952" "2.552" "931.6" "920.6" "832.5" "991.7" "871.4" "856.3" "884.8" "770.3" "886.8" "2377.7" "" "" "" "" "" "" "" "" "" "" "826.1" "762.5" "726.4" "741.6" "726.7" "786.6" "747.8" "636.7" "813.3" "2377.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "High" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.000" "False" "33.916" "27" "9" "14" "9" "278" "29.5" "8.56" "43.75" "9" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "Peroxisomal protein import; RA biosynthesis pathway" "" "2" "0" "0.997" "1.009" "1.000" "1.045" "1.042" "1.073" "1.059" "0.908" "0.499" "847.6" "845.4" "854.8" "847.3" "885.8" "883.4" "909.8" "897.5" "769.5" "422.9" "" "" "" "" "" "" "" "" "" "" "751.6" "700.3" "745.9" "633.7" "738.6" "811.5" "768.9" "741.8" "705.7" "422.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "High" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.000" "False" "33.910" "17" "5" "11" "5" "375" "41.4" "5.31" "38.02" "5" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "0.999" "1.003" "0.976" "0.939" "0.976" "1.067" "1.074" "1.052" "1.047" "519.0" "518.7" "520.7" "506.5" "487.4" "506.5" "554.0" "557.3" "546.3" "543.4" "" "" "" "" "" "" "" "" "" "" "460.3" "429.7" "454.3" "378.8" "406.4" "465.3" "468.2" "460.6" "501.0" "543.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "33.901" "25" "4" "5" "4" "204" "21.6" "5.48" "24.82" "4" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "1.083" "1.048" "1.109" "1.093" "1.082" "1.140" "1.059" "1.007" "0.591" "552.4" "598.3" "578.7" "612.7" "603.7" "597.7" "629.6" "584.8" "556.4" "326.3" "" "" "" "" "" "" "" "" "" "" "489.9" "495.6" "504.9" "458.2" "503.4" "549.1" "532.1" "483.4" "510.3" "326.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.000" "False" "33.849" "16" "5" "7" "5" "398" "46.4" "5.54" "27.18" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "Intra-Golgi traffic" "2q37 copy number variation syndrome" "2" "0" "0.925" "0.908" "1.026" "0.917" "0.947" "0.941" "0.928" "0.860" "0.786" "709.0" "655.6" "643.9" "727.2" "650.3" "671.6" "667.0" "658.2" "609.4" "557.0" "" "" "" "" "" "" "" "" "" "" "628.8" "543.0" "561.8" "543.8" "542.3" "617.0" "563.7" "544.0" "558.9" "557.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974578878725693910" "False" "High" "IsMasterProtein" "P45984" "Mitogen-activated protein kinase 9 OS=Homo sapiens OX=9606 GN=MAPK9 PE=1 SV=2" "0.000" "False" "33.840" "20" "9" "11" "5" "424" "48.1" "5.63" "34.49" "9" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5601" "ENSG00000050748" "MAPK9" "A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9; hsa:5601; P45984; Q15708; Q15710; Q15711; Q8N5C5" "Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy; Alzheimer's disease; GDNF signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway" "66" "2" "1.004" "0.986" "1.016" "1.024" "0.969" "1.039" "1.105" "1.010" "0.825" "495.0" "497.2" "487.8" "503.0" "506.6" "479.6" "514.2" "546.9" "499.8" "408.2" "" "" "" "" "" "" "" "" "" "" "438.9" "411.8" "425.7" "376.2" "422.4" "440.6" "434.6" "452.0" "458.4" "408.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2714329419910624829" "False" "High" "IsMasterProtein" "P47985" "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2" "0.000" "False" "33.814" "15" "5" "8" "5" "274" "29.6" "8.32" "31.55" "5" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "7386" "ENSG00000169021" "UQCRFS1" "A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation" "6" "0" "1.064" "1.044" "1.097" "1.108" "1.046" "1.006" "1.014" "0.984" "0.782" "738.9" "786.2" "771.3" "810.5" "818.4" "773.0" "743.3" "749.6" "727.2" "577.6" "" "" "" "" "" "" "" "" "" "" "655.2" "651.2" "673.0" "606.2" "682.4" "710.1" "628.2" "619.6" "667.0" "577.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6920554993800994285" "False" "High" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "0.000" "False" "33.810" "4" "5" "7" "3" "1626" "183.2" "8.00" "23.54" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "SUMOylation of DNA replication proteins" "" "1" "1" "1.045" "1.019" "1.005" "1.033" "1.093" "0.887" "0.924" "1.010" "1.344" "520.6" "544.2" "530.3" "523.4" "537.9" "569.1" "461.9" "481.0" "525.9" "699.4" "" "" "" "" "" "" "" "" "" "" "461.6" "450.8" "462.7" "391.4" "448.5" "522.8" "390.4" "397.6" "482.3" "699.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6780722004559034825" "False" "High" "IsMasterProtein" "P35520" "Cystathionine beta-synthase OS=Homo sapiens OX=9606 GN=CBS PE=1 SV=2" "0.000" "False" "33.805" "16" "8" "9" "8" "551" "60.5" "6.65" "30.81" "8" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00291, Pf00571" "102724560; 875" "ENSG00000160200" "CBS" "B2R993; D3DSK4; hsa:102724560; hsa:875; P35520; Q99425; Q9BWC5" "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Vitamin D receptor pathway; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis; Ciliary landscape" "13" "0" "1.051" "0.984" "1.045" "1.016" "1.013" "1.069" "1.034" "0.939" "0.570" "658.0" "691.5" "647.6" "687.4" "668.4" "666.8" "703.4" "680.6" "617.7" "374.8" "" "" "" "" "" "" "" "" "" "" "583.5" "572.8" "565.1" "514.1" "557.3" "612.5" "594.5" "562.6" "566.5" "374.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5517999105151406307" "False" "High" "IsMasterProtein" "Q9NWT1" "p21-activated protein kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAK1IP1 PE=1 SV=2" "0.000" "False" "33.787" "20" "7" "8" "7" "392" "43.9" "8.91" "29.94" "7" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf00400" "55003" "ENSG00000111845; ENSG00000285226" "PAK1IP1" "hsa:55003; Q5T4J2; Q96QJ8; Q96T87; Q9NWT1" "" "" "0" "0" "0.970" "0.885" "1.026" "0.966" "0.929" "1.293" "1.154" "1.077" "0.520" "343.2" "333.0" "303.7" "352.0" "331.7" "318.8" "443.9" "396.0" "369.7" "178.7" "" "" "" "" "" "" "" "" "" "" "304.4" "275.9" "265.0" "263.3" "276.6" "292.8" "375.2" "327.3" "339.1" "178.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4523012747677362471" "False" "High" "IsMasterProtein" "Q9H0Z9" "RNA-binding protein 38 OS=Homo sapiens OX=9606 GN=RBM38 PE=1 SV=2" "0.000" "False" "33.769" "22" "4" "8" "4" "239" "25.5" "8.65" "26.14" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "55544" "ENSG00000132819" "RBM38" "A6NDK1; A6NMU6; hsa:55544; Q15350; Q15351; Q9BYK3; Q9BYK4; Q9H0Z9" "" "" "0" "0" "1.081" "0.981" "1.193" "1.007" "1.029" "1.078" "0.859" "1.009" "3.673" "628.2" "678.9" "616.2" "749.1" "632.5" "646.5" "677.4" "539.5" "633.6" "2307.1" "" "" "" "" "" "" "" "" "" "" "557.0" "562.4" "537.7" "560.2" "527.4" "593.9" "572.5" "445.9" "581.1" "2307.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7008442538818735376" "False" "High" "IsMasterProtein" "Q8N4T8" "3-oxoacyl-[acyl-carrier-protein] reductase OS=Homo sapiens OX=9606 GN=CBR4 PE=1 SV=3" "0.000" "False" "33.767" "33" "6" "6" "6" "237" "25.3" "9.33" "24.91" "6" "cell organization and biogenesis;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf13561" "84869" "ENSG00000145439" "CBR4" "hsa:84869; Q8N4T8; Q8WTW8; Q96K93" "Fatty acyl-CoA biosynthesis" "" "1" "0" "1.056" "1.118" "1.098" "1.067" "1.039" "1.096" "1.106" "1.126" "0.502" "560.4" "592.0" "626.3" "615.5" "597.7" "582.1" "614.1" "619.7" "631.3" "281.3" "" "" "" "" "" "" "" "" "" "" "497.0" "490.3" "546.5" "460.3" "498.4" "534.7" "519.0" "512.2" "579.0" "281.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3951454542439150493" "False" "High" "IsMasterProtein" "Q9HB40" "Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1" "0.000" "False" "33.761" "11" "5" "9" "5" "452" "50.8" "5.81" "33.49" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00450" "59342" "ENSG00000121064" "SCPEP1" "hsa:59342; Q96A94; Q9H3F0; Q9HB40" "" "" "0" "0" "1.020" "1.028" "1.043" "1.022" "1.059" "1.036" "1.056" "1.003" "0.629" "962.4" "981.3" "989.8" "1003.8" "983.8" "1019.2" "997.3" "1016.3" "965.2" "605.2" "" "" "" "" "" "" "" "" "" "" "853.4" "812.9" "863.6" "750.7" "820.4" "936.2" "842.9" "840.1" "885.3" "605.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "33.746" "24" "9" "11" "9" "396" "45.4" "8.91" "36.52" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "" "2" "0" "1.035" "0.900" "1.068" "0.953" "0.943" "1.013" "0.250" "0.944" "13.071" "755.8" "782.4" "680.2" "807.2" "720.5" "712.6" "765.7" "189.3" "713.2" "9878.6" "" "" "" "" "" "" "" "" "" "" "670.2" "648.1" "593.5" "603.7" "600.8" "654.6" "647.2" "156.4" "654.1" "9878.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "33.730" "19" "6" "6" "6" "313" "35.7" "7.01" "22.83" "6" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "9" "0" "1.126" "1.140" "1.306" "1.188" "0.968" "1.188" "0.760" "1.093" "7.357" "204.0" "229.7" "232.6" "266.5" "242.4" "197.4" "242.4" "155.0" "223.0" "1500.9" "" "" "" "" "" "" "" "" "" "" "180.9" "190.2" "202.9" "199.3" "202.2" "181.3" "204.9" "128.1" "204.6" "1500.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208220757799786637" "False" "High" "IsMasterProtein" "Q9BTC8" "Metastasis-associated protein MTA3 OS=Homo sapiens OX=9606 GN=MTA3 PE=1 SV=2" "0.000" "False" "33.601" "17" "10" "11" "6" "594" "67.5" "8.57" "33.46" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "57504" "ENSG00000057935" "MTA3" "hsa:57504; Q9BTC8; Q9NSP2; Q9ULF4" "Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Pre-implantation embryo; Effect of progerin on genes involved in progeria" "7" "2" "0.986" "0.943" "0.996" "0.952" "0.952" "0.961" "0.741" "0.918" "5.056" "693.6" "684.0" "654.0" "691.1" "660.0" "660.2" "666.8" "514.0" "636.5" "3506.8" "" "" "" "" "" "" "" "" "" "" "615.1" "566.6" "570.6" "516.8" "550.4" "606.5" "563.6" "424.8" "583.8" "3506.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643109724268830478" "False" "High" "IsMasterProtein" "Q8WUH1" "Protein Churchill OS=Homo sapiens OX=9606 GN=CHURC1 PE=1 SV=3" "0.000" "False" "33.562" "33" "4" "9" "4" "112" "12.9" "4.84" "34.88" "4" "signal transduction;other biological processes" "" "other molecular function" "Pf06573" "91612" "ENSG00000258289" "CHURC1" "A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; hsa:91612; Q8WUH1; Q9H3K7" "" "" "0" "0" "0.993" "1.015" "0.990" "1.057" "1.018" "1.064" "1.029" "1.013" "0.688" "1317.1" "1307.9" "1336.3" "1303.5" "1391.5" "1341.3" "1401.7" "1355.3" "1334.4" "906.0" "" "" "" "" "" "" "" "" "" "" "1167.9" "1083.4" "1166.0" "974.8" "1160.3" "1232.1" "1184.6" "1120.2" "1223.9" "906.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.000" "False" "33.538" "13" "6" "9" "6" "458" "50.3" "6.10" "29.00" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "" "5" "0" "1.116" "0.956" "1.237" "1.090" "1.072" "1.107" "1.017" "1.005" "1.578" "391.2" "436.8" "373.9" "483.8" "426.5" "419.4" "433.1" "397.9" "393.2" "617.5" "" "" "" "" "" "" "" "" "" "" "346.9" "361.8" "326.3" "361.8" "355.7" "385.3" "366.0" "328.9" "360.6" "617.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "33.534" "36" "5" "10" "5" "174" "19.1" "5.05" "42.60" "5" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "Purine catabolism" "" "1" "0" "1.053" "1.118" "1.082" "1.099" "1.024" "1.113" "1.096" "1.043" "0.654" "905.2" "953.0" "1011.8" "979.0" "995.2" "927.0" "1007.4" "991.7" "944.3" "591.8" "" "" "" "" "" "" "" "" "" "" "802.7" "789.4" "882.8" "732.2" "829.9" "851.5" "851.4" "819.7" "866.1" "591.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5401388015032906251" "False" "High" "IsMasterProtein" "O95402" "Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2" "0.000" "False" "33.493" "11" "6" "8" "6" "600" "65.4" "9.16" "26.43" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08711, Pf15693, Pf15694" "9441" "ENSG00000105085" "MED26" "A1A4S3; hsa:9441; O95402; Q0VGB6" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "0.986" "0.932" "0.960" "0.910" "0.858" "0.826" "0.872" "0.879" "0.798" "1188.3" "1172.2" "1107.7" "1140.4" "1081.5" "1019.3" "981.8" "1036.1" "1045.0" "947.7" "" "" "" "" "" "" "" "" "" "" "1053.7" "971.0" "966.5" "852.8" "901.8" "936.3" "829.8" "856.4" "958.4" "947.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5483705117675463598" "False" "High" "IsMasterProtein" "P10321" "HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3" "0.000" "False" "33.480" "16" "5" "6" "1" "366" "40.6" "6.04" "25.80" "5" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3107" "ENSG00000204525" "HLA-C" "hsa:3107; O02863; O02864; O02865; O02866; O02958; O19505; O19652; O19676; O62879; O62882; O62883; O62888; O78060; O78061; O78062; O78063; O78067; O78068; O78069; O78072; O78083; O78090; O78091; O78149; O78165; O78166; O78178; O78202; O78203; O78211; O78214; P04222; P10321; P30499; P30500; P30501; P30502; P30503; P30504; P30505; P30506; P30507; P30508; P30509; P30510; P79498; Q07000; Q29631; Q29641; Q29643; Q29652; Q29743; Q29768; Q29862; Q29864; Q29865; Q29867; Q29921; Q29959; Q29960; Q29963; Q29986; Q29989; Q29990; Q29991; Q29992; Q29993; Q30192; Q31605; Q31627; Q860R1; Q860R2; Q95463; Q95603; Q95604; Q99528; Q9BD28; Q9GIK4; Q9GIK8; Q9GJ33; Q9MY30; Q9MY31; Q9MY35; Q9MY49; Q9MY74; Q9MYI3; Q9TNN7; Q9TNZ8; Q9TPS4; Q9TPV8; Q9TPX2; Q9TQB4; Q9TQJ5; Q9TQP9; Q9UM32; Q9UM33; Q9UM42; Q9UQS9" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 interactions; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777043105444546084" "False" "High" "IsMasterProtein" "P00387" "NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3" "0.000" "False" "33.449" "23" "6" "10" "6" "301" "34.2" "7.59" "36.02" "6" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00175, Pf00970" "1727" "ENSG00000100243" "CYB5R3" "B1AHF2; B7Z7L3; hsa:1727; O75675; P00387; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56" "Phase I - Functionalization of compounds; Neutrophil degranulation; Vitamin C (ascorbate) metabolism" "Oxidation by cytochrome P450" "4" "0" "1.069" "0.970" "1.064" "1.084" "1.016" "1.034" "0.983" "1.014" "0.766" "658.6" "703.7" "638.7" "700.8" "714.0" "668.8" "680.8" "647.3" "668.1" "504.8" "" "" "" "" "" "" "" "" "" "" "584.0" "582.9" "557.3" "524.1" "595.4" "614.4" "575.4" "535.0" "612.7" "504.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4995074517937679177" "False" "High" "IsMasterProtein" "O95628" "CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3" "0.000" "False" "33.435" "17" "8" "8" "8" "575" "63.5" "7.03" "31.87" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf14570" "4850" "ENSG00000080802" "CNOT4" "B7Z6I4; E7ET38; F8VQP3; O95339; O95627; O95628; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.039" "1.066" "1.084" "1.041" "1.008" "1.016" "1.050" "1.074" "0.740" "585.9" "608.7" "624.5" "635.4" "610.1" "590.7" "595.4" "615.0" "629.3" "433.4" "" "" "" "" "" "" "" "" "" "" "519.6" "504.2" "544.9" "475.2" "508.8" "542.7" "503.2" "508.3" "577.1" "433.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "33.408" "27" "4" "8" "4" "184" "20.9" "6.34" "28.35" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "Joubert syndrome" "4" "0" "1.008" "0.987" "1.102" "1.000" "0.965" "1.170" "1.158" "0.922" "0.662" "614.2" "619.3" "606.1" "676.7" "613.9" "592.7" "718.5" "711.4" "566.6" "406.9" "" "" "" "" "" "" "" "" "" "" "544.7" "513.0" "528.8" "506.1" "511.9" "544.5" "607.3" "588.0" "519.7" "406.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1811232654349558643" "False" "High" "IsMasterProtein" "P18846" "Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2" "0.000" "False" "33.404" "26" "7" "10" "5" "271" "29.2" "8.37" "37.68" "7" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "466" "ENSG00000123268" "ATF1" "B4DRF9; hsa:466; P18846; P25168; Q9H4A8" "NGF-stimulated transcription; CREB phosphorylation" "Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling" "9" "2" "1.035" "1.009" "0.989" "0.984" "1.029" "1.032" "1.028" "0.963" "0.531" "1800.4" "1863.6" "1816.8" "1781.0" "1772.4" "1853.5" "1858.7" "1850.8" "1733.2" "956.7" "" "" "" "" "" "" "" "" "" "" "1596.6" "1543.7" "1585.3" "1332.0" "1478.0" "1702.6" "1570.9" "1529.8" "1589.6" "956.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385363124040609264" "False" "High" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "0.000" "False" "33.396" "16" "9" "11" "8" "504" "57.5" "6.15" "33.64" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Neutrophil degranulation; Viral mRNA Translation; PKR-mediated signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "7" "0" "0.887" "0.870" "0.830" "0.892" "0.916" "1.001" "0.931" "0.999" "2.014" "977.6" "867.2" "850.6" "811.0" "871.9" "895.4" "978.5" "909.9" "977.0" "1968.7" "" "" "" "" "" "" "" "" "" "" "866.9" "718.3" "742.2" "606.5" "727.0" "822.6" "827.0" "752.1" "896.1" "1968.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "33.381" "28" "6" "8" "6" "210" "24.5" "5.95" "26.64" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "1.005" "1.019" "1.105" "1.068" "1.064" "1.052" "0.950" "0.968" "1.568" "920.7" "925.2" "938.6" "1017.1" "983.3" "979.5" "968.5" "875.0" "891.4" "1443.6" "" "" "" "" "" "" "" "" "" "" "816.5" "766.4" "819.0" "760.7" "820.0" "899.8" "818.6" "723.3" "817.5" "1443.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348020526010624498" "False" "High" "IsMasterProtein" "Q13469" "Nuclear factor of activated T-cells, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=NFATC2 PE=1 SV=2" "0.000" "False" "33.371" "9" "8" "8" "8" "925" "100.1" "7.28" "22.95" "8" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4773" "ENSG00000101096" "NFATC2" "B5B2N8; B5B2N9; B5B2P0; B5B2P2; B5B2P3; hsa:4773; Q13468; Q13469; Q5TFW7; Q5TFW8; Q9NPX6; Q9NQH3; Q9UJR2" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)" "Heart development; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Hematopoietic stem cell differentiation; Vitamin D receptor pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; CAMKK2 pathway; 16p11.2 distal deletion syndrome; Calcium mediated T-cell apoptosis involved in inclusion body myositis; T-cell receptor signaling pathway" "21" "0" "1.093" "1.022" "1.074" "1.016" "1.012" "1.131" "0.931" "1.105" "2.773" "178.1" "194.7" "182.0" "191.3" "180.9" "180.2" "201.4" "165.8" "196.9" "493.9" "" "" "" "" "" "" "" "" "" "" "157.9" "161.3" "158.8" "143.1" "150.8" "165.5" "170.2" "137.0" "180.6" "493.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5808192534094495875" "False" "High" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "0.000" "False" "33.363" "8" "8" "8" "8" "981" "108.8" "6.40" "24.46" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "Non-small cell lung cancer" "4" "0" "1.008" "0.944" "0.986" "1.014" "0.909" "0.991" "0.835" "0.994" "2.864" "301.6" "304.0" "284.8" "297.3" "305.9" "274.2" "298.8" "251.7" "299.8" "863.8" "" "" "" "" "" "" "" "" "" "" "267.4" "251.8" "248.5" "222.4" "255.1" "251.9" "252.5" "208.1" "275.0" "863.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6484824469682462574" "False" "High" "IsMasterProtein" "Q17R31" "Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1" "0.000" "False" "33.344" "26" "6" "7" "6" "274" "30.3" "7.15" "26.77" "6" "" "nucleus" "other molecular function" "Pf01026" "128387" "ENSG00000203705" "TATDN3" "A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; hsa:128387; Q17R31; Q4G0L1" "" "" "0" "0" "1.349" "1.051" "1.200" "1.201" "1.262" "1.186" "1.109" "1.186" "0.610" "442.7" "597.2" "465.4" "531.2" "531.7" "558.5" "525.2" "490.9" "524.8" "269.8" "" "" "" "" "" "" "" "" "" "" "392.5" "494.7" "406.1" "397.2" "443.3" "513.1" "443.9" "405.7" "481.3" "269.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5432716996293136503" "False" "High" "IsMasterProtein" "P05161" "Ubiquitin-like protein ISG15 OS=Homo sapiens OX=9606 GN=ISG15 PE=1 SV=5" "0.000" "False" "33.321" "35" "5" "7" "5" "165" "17.9" "7.44" "26.90" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00240" "9636" "ENSG00000187608" "ISG15" "hsa:9636; P05161; Q5SVA4; Q7Z2G2; Q96GF0" "RSV-host interactions; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PKR-mediated signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Interferon alpha/beta signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "Novel intracellular components of RIG-I-like receptor pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system; Type II interferon signaling" "17" "0" "0.879" "0.954" "0.943" "1.030" "0.875" "1.034" "0.735" "0.932" "5.629" "294.3" "258.6" "280.7" "277.5" "303.2" "257.4" "304.3" "216.4" "274.3" "1656.6" "" "" "" "" "" "" "" "" "" "" "261.0" "214.2" "244.9" "207.5" "252.9" "236.5" "257.2" "178.9" "251.6" "1656.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6652011194005899795" "False" "High" "IsMasterProtein" "P29083" "General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2" "0.000" "False" "33.194" "14" "5" "7" "5" "439" "49.4" "4.82" "27.65" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02002, Pf08271, Pf11521" "2960" "ENSG00000153767" "GTF2E1" "hsa:2960; P29083; Q16103" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "0.915" "0.517" "0.451" "0.448" "0.591" "0.613" "0.491" "0.727" "1.379" "232.0" "212.2" "120.1" "104.8" "103.9" "137.0" "142.2" "114.0" "168.7" "320.0" "" "" "" "" "" "" "" "" "" "" "205.8" "175.8" "104.8" "78.3" "86.6" "125.9" "120.2" "94.2" "154.7" "320.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.000" "False" "33.178" "28" "7" "9" "7" "264" "30.2" "7.50" "29.46" "7" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "1.048" "0.814" "1.054" "1.068" "0.951" "1.043" "0.949" "0.818" "0.659" "414.5" "434.4" "337.5" "437.0" "442.9" "394.2" "432.5" "393.2" "339.1" "273.3" "" "" "" "" "" "" "" "" "" "" "367.6" "359.8" "294.5" "326.8" "369.3" "362.1" "365.6" "325.0" "311.0" "273.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3119089922168410835" "False" "High" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "0.000" "False" "33.166" "53" "6" "13" "6" "129" "13.7" "8.81" "35.06" "6" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940; ENSG00000291596" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Mitochondrial protein degradation; Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "8" "0" "0.970" "0.911" "0.919" "0.962" "0.912" "0.807" "0.933" "0.977" "0.618" "676.4" "656.0" "616.5" "621.8" "651.1" "616.9" "545.9" "631.3" "661.0" "417.8" "" "" "" "" "" "" "" "" "" "" "599.8" "543.4" "538.0" "465.0" "542.9" "566.7" "461.4" "521.8" "606.3" "417.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7226470696601852520" "False" "High" "IsMasterProtein" "Q9H0A8" "COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1" "0.000" "False" "33.145" "30" "6" "10" "6" "199" "21.8" "7.31" "31.22" "6" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf07258, Pf21672" "54939" "ENSG00000140365" "COMMD4" "B2RBN4; H3BUL2; hsa:54939; Q7L637; Q9H0A8; Q9NX43" "Neddylation" "" "1" "0" "1.021" "1.000" "1.008" "0.986" "1.036" "1.022" "0.996" "0.944" "1.398" "1012.1" "1032.9" "1012.1" "1020.6" "997.6" "1048.6" "1034.6" "1008.3" "955.0" "1414.7" "" "" "" "" "" "" "" "" "" "" "897.6" "855.6" "883.1" "763.3" "831.9" "963.2" "874.4" "833.4" "875.9" "1414.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.000" "False" "33.127" "6" "9" "10" "9" "1368" "156.4" "7.40" "35.23" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.223" "1.021" "1.164" "1.128" "1.099" "1.044" "1.019" "0.983" "1.146" "1103.0" "1348.5" "1126.6" "1283.9" "1244.6" "1212.4" "1151.0" "1123.6" "1084.6" "1264.1" "" "" "" "" "" "" "" "" "" "" "978.1" "1117.0" "983.0" "960.2" "1037.8" "1113.7" "972.8" "928.7" "994.7" "1264.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "33.114" "48" "4" "6" "4" "115" "12.8" "9.63" "25.75" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "15" "0" "1.103" "1.014" "1.149" "1.139" "1.069" "1.047" "1.127" "1.026" "1.189" "540.1" "595.9" "547.4" "620.4" "615.0" "577.6" "565.6" "608.5" "554.1" "642.4" "" "" "" "" "" "" "" "" "" "" "478.9" "493.6" "477.6" "464.0" "512.8" "530.6" "478.0" "503.0" "508.2" "642.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "33.104" "23" "9" "12" "9" "340" "38.5" "7.20" "36.82" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "0.998" "0.963" "1.162" "1.025" "1.065" "1.955" "1.690" "1.710" "2.697" "865.9" "864.3" "833.7" "1006.1" "887.2" "922.2" "1692.5" "1463.6" "1480.3" "2335.0" "" "" "" "" "" "" "" "" "" "" "767.8" "716.0" "727.5" "752.4" "739.8" "847.1" "1430.5" "1209.8" "1357.7" "2335.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "33.099" "40" "8" "9" "8" "187" "21.6" "7.59" "30.21" "8" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "0.969" "0.984" "0.986" "0.987" "1.001" "0.973" "1.031" "1.018" "0.742" "967.8" "938.1" "952.8" "954.0" "955.3" "968.7" "941.6" "998.3" "985.1" "718.0" "" "" "" "" "" "" "" "" "" "" "858.2" "777.1" "831.3" "713.5" "796.6" "889.9" "795.8" "825.1" "903.5" "718.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "High" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.000" "False" "33.039" "16" "9" "9" "9" "508" "56.0" "7.11" "30.68" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "0.978" "0.941" "1.002" "0.999" "0.944" "0.908" "0.739" "0.982" "3.546" "601.9" "588.7" "566.2" "603.3" "601.2" "567.9" "546.5" "444.5" "590.9" "2134.4" "" "" "" "" "" "" "" "" "" "" "533.7" "487.7" "494.0" "451.2" "501.4" "521.7" "461.9" "367.4" "542.0" "2134.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855179925451267268" "False" "High" "IsMasterProtein" "Q96F24" "Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1" "0.000" "False" "33.014" "28" "9" "12" "9" "287" "32.4" "5.87" "42.50" "9" "other metabolic processes;stress response" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08961, Pf17169" "29982" "ENSG00000148572" "NRBF2" "A6PW36; B4DWS0; hsa:29982; Q86UR2; Q96F24; Q96NP6; Q9H0S9; Q9H2I2" "" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "2" "0" "0.957" "0.920" "0.878" "0.849" "0.836" "0.783" "0.895" "0.903" "0.750" "3257.4" "3118.6" "2996.7" "2859.0" "2767.0" "2722.1" "2550.3" "2914.0" "2942.5" "2441.6" "" "" "" "" "" "" "" "" "" "" "2888.6" "2583.3" "2614.7" "2138.1" "2307.3" "2500.6" "2155.4" "2408.6" "2698.7" "2441.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819248738273411506" "False" "High" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "0.000" "False" "32.929" "5" "8" "8" "8" "1849" "206.8" "6.52" "25.97" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "1.083" "1.013" "1.076" "1.090" "1.007" "1.204" "1.022" "1.155" "4.579" "404.7" "438.4" "409.8" "435.4" "441.0" "407.4" "487.4" "413.7" "467.3" "1852.8" "" "" "" "" "" "" "" "" "" "" "358.9" "363.2" "357.6" "325.6" "367.7" "374.3" "412.0" "342.0" "428.6" "1852.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "32.924" "11" "9" "12" "3" "766" "86.6" "8.72" "45.07" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "3" "0" "0.960" "0.920" "1.065" "0.965" "0.864" "0.845" "0.997" "0.881" "0.696" "289.7" "278.2" "266.6" "308.6" "279.6" "250.3" "244.9" "289.0" "255.1" "201.6" "" "" "" "" "" "" "" "" "" "" "256.9" "230.4" "232.6" "230.8" "233.1" "229.9" "207.0" "238.9" "234.0" "201.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "32.912" "15" "6" "8" "6" "464" "51.6" "6.48" "31.23" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Urea cycle" "Alanine and aspartate metabolism" "2" "0" "0.988" "0.950" "1.023" "1.023" "1.026" "1.021" "1.015" "1.034" "0.787" "564.5" "557.5" "536.3" "577.6" "577.4" "579.1" "576.1" "572.8" "583.6" "444.2" "" "" "" "" "" "" "" "" "" "" "500.6" "461.8" "468.0" "432.0" "481.5" "531.9" "486.9" "473.5" "535.2" "444.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9155703229501675198" "False" "High" "IsMasterProtein" "P31751" "RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2" "0.000" "False" "32.877" "16" "7" "9" "7" "481" "55.7" "6.37" "31.60" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "208" "ENSG00000105221" "AKT2" "B2RBD8; hsa:208; P31751; Q05BV0; Q0VAN0; Q0VAN1; Q68GC0" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Regulation of TP53 Degradation; CTLA4 inhibitory signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Activation of AKT2; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; PDE3B signalling; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Cardiac hypertrophic response; Focal adhesion; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Acute myeloid leukemia; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "83" "0" "1.160" "0.886" "1.098" "0.984" "0.945" "1.000" "0.918" "0.956" "1.880" "806.6" "935.5" "714.8" "886.1" "793.9" "762.2" "806.8" "740.5" "771.4" "1516.4" "" "" "" "" "" "" "" "" "" "" "715.3" "774.9" "623.7" "662.6" "662.0" "700.2" "681.9" "612.0" "707.5" "1516.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "32.823" "6" "8" "8" "6" "1512" "164.8" "9.69" "26.01" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes" "" "2" "0" "1.164" "0.845" "1.464" "1.157" "0.750" "1.412" "1.029" "0.953" "0.801" "245.3" "285.6" "207.3" "359.2" "283.8" "183.9" "346.4" "252.3" "233.6" "196.6" "" "" "" "" "" "" "" "" "" "" "217.5" "236.5" "180.9" "268.6" "236.6" "169.0" "292.8" "208.6" "214.3" "196.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "32.821" "9" "5" "8" "5" "739" "83.3" "6.70" "29.16" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "4p16.3 copy number variation" "3" "0" "1.056" "1.046" "0.936" "1.008" "1.158" "0.978" "1.007" "1.058" "0.346" "471.2" "497.5" "493.1" "440.9" "474.9" "545.7" "460.7" "474.3" "498.7" "162.8" "" "" "" "" "" "" "" "" "" "" "417.9" "412.1" "430.2" "329.7" "396.0" "501.2" "389.4" "392.1" "457.4" "162.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5364683920046459506" "False" "High" "IsMasterProtein" "O75340" "Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1" "0.000" "False" "32.815" "26" "5" "6" "5" "191" "21.9" "5.40" "25.52" "5" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13499" "10016" "ENSG00000249915" "PDCD6" "B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0" "" "Epithelial to mesenchymal transition in colorectal cancer" "1" "0" "0.975" "0.880" "1.029" "1.010" "1.028" "0.992" "0.946" "0.928" "1.566" "683.6" "666.8" "601.6" "703.6" "690.2" "703.0" "678.2" "646.6" "634.1" "1070.6" "" "" "" "" "" "" "" "" "" "" "606.2" "552.3" "524.9" "526.2" "575.5" "645.8" "573.1" "534.4" "581.5" "1070.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "High" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.000" "False" "32.769" "19" "9" "11" "9" "441" "49.9" "5.07" "39.05" "9" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "0.872" "0.937" "0.880" "0.822" "0.899" "0.925" "0.913" "0.964" "1.126" "616.9" "538.0" "578.1" "542.7" "507.4" "554.6" "570.9" "563.6" "594.8" "694.4" "" "" "" "" "" "" "" "" "" "" "547.1" "445.6" "504.4" "405.9" "423.1" "509.4" "482.5" "465.8" "545.5" "694.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-618905356124197811" "False" "High" "IsMasterProtein" "Q9NQZ5" "StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2" "0.000" "False" "32.751" "15" "5" "7" "5" "370" "43.1" "8.95" "27.91" "5" "" "other membranes;mitochondrion" "other molecular function" "Pf01852" "56910" "ENSG00000084090" "STARD7" "D3DXG9; hsa:56910; Q53T44; Q6GU43; Q969M6; Q9NQZ5" "Mitochondrial protein degradation; Synthesis of PC" "2q11.2 copy number variation syndrome" "3" "0" "0.971" "0.928" "0.964" "0.899" "0.834" "0.886" "0.875" "0.914" "1.386" "781.3" "758.5" "725.2" "753.5" "702.6" "651.5" "692.1" "683.9" "713.7" "1082.6" "" "" "" "" "" "" "" "" "" "" "692.8" "628.3" "632.8" "563.5" "585.9" "598.5" "584.9" "565.3" "654.6" "1082.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4269157593658569788" "False" "High" "IsMasterProtein" "Q9NXV2" "BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1" "0.000" "False" "32.745" "30" "6" "6" "6" "234" "26.1" "6.24" "24.66" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02214" "54442" "ENSG00000167977" "KCTD5" "D3DU96; hsa:54442; Q9NXV2" "" "" "0" "0" "1.004" "0.963" "1.013" "0.974" "1.100" "1.077" "1.083" "0.964" "0.721" "545.3" "547.4" "525.2" "552.5" "530.9" "599.5" "587.1" "590.2" "525.8" "393.2" "" "" "" "" "" "" "" "" "" "" "483.5" "453.4" "458.3" "413.2" "442.7" "550.7" "496.2" "487.9" "482.2" "393.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875148632163355861" "False" "High" "IsMasterProtein" "Q9Y3D2" "Methionine-R-sulfoxide reductase B2, mitochondrial OS=Homo sapiens OX=9606 GN=MSRB2 PE=1 SV=2" "0.000" "False" "32.744" "50" "6" "6" "6" "182" "19.5" "8.63" "26.12" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01641" "22921" "ENSG00000148450" "MSRB2" "hsa:22921; Q17R44; Q4G1C7; Q9Y3D2; Q9Y5W6" "Protein repair" "Sulindac metabolic pathway; Methionine de novo and salvage pathway" "3" "0" "0.956" "1.037" "0.928" "0.985" "1.066" "0.920" "0.939" "0.977" "0.655" "661.7" "632.9" "686.5" "613.9" "651.9" "705.1" "608.5" "621.5" "646.8" "433.7" "" "" "" "" "" "" "" "" "" "" "586.8" "524.2" "599.0" "459.1" "543.6" "647.7" "514.3" "513.7" "593.2" "433.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490107994498796069" "False" "High" "IsMasterProtein" "Q8WVC0" "RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1" "0.000" "False" "32.721" "17" "9" "13" "9" "666" "75.4" "4.51" "30.02" "9" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf04004" "123169" "ENSG00000166477" "LEO1" "hsa:123169; Q8WVC0; Q96N99" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "6" "0" "1.000" "0.918" "0.930" "0.941" "1.028" "0.852" "0.849" "0.936" "1.054" "707.4" "707.5" "649.4" "658.0" "665.8" "727.0" "602.4" "600.9" "662.0" "745.5" "" "" "" "" "" "" "" "" "" "" "627.3" "586.1" "566.7" "492.1" "555.1" "667.9" "509.1" "496.7" "607.2" "745.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "32.703" "42" "8" "20" "7" "127" "14.1" "9.03" "63.78" "8" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "0.921" "0.933" "0.768" "0.811" "0.715" "0.702" "0.809" "0.871" "0.396" "2794.1" "2574.1" "2606.3" "2145.2" "2267.1" "1998.4" "1961.5" "2260.9" "2433.8" "1107.0" "" "" "" "" "" "" "" "" "" "" "2477.8" "2132.3" "2274.1" "1604.3" "1890.5" "1835.7" "1657.7" "1868.8" "2232.1" "1107.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "High" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.000" "False" "32.689" "3" "5" "7" "5" "2285" "241.9" "6.70" "30.09" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "7" "0" "1.085" "1.097" "0.987" "1.068" "1.031" "0.933" "0.920" "1.049" "1.946" "301.7" "327.4" "331.0" "297.7" "322.4" "311.0" "281.6" "277.6" "316.4" "587.2" "" "" "" "" "" "" "" "" "" "" "267.5" "271.2" "288.8" "222.6" "268.8" "285.7" "238.0" "229.4" "290.2" "587.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991903496179440797" "False" "High" "IsMasterProtein" "A8CG34" "Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3" "0.000" "False" "32.658" "6" "6" "8" "6" "1229" "125.0" "10.37" "28.35" "6" "transport" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf15229" "" "ENSG00000272391" "POM121C" "A0A075B7F8; A0A087WY75; A8CG34; O75115; Q9Y2N3; Q9Y4S7" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "0.938" "0.935" "0.982" "0.924" "0.928" "0.891" "0.923" "0.983" "1.031" "476.7" "447.2" "445.8" "468.3" "440.6" "442.4" "424.9" "439.8" "468.8" "491.6" "" "" "" "" "" "" "" "" "" "" "422.7" "370.5" "389.0" "350.2" "367.4" "406.4" "359.1" "363.5" "429.9" "491.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "32.649" "10" "4" "8" "2" "473" "51.2" "8.03" "29.54" "4" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "30" "0" "0.955" "0.933" "0.909" "0.869" "1.053" "0.934" "0.769" "0.872" "1.286" "47.5" "45.4" "44.3" "43.2" "41.3" "50.0" "44.4" "36.5" "41.4" "61.1" "" "" "" "" "" "" "" "" "" "" "42.1" "37.6" "38.7" "32.3" "34.4" "45.9" "37.5" "30.2" "38.0" "61.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7438164124212550785" "False" "High" "IsMasterProtein" "Q96EV8" "Dysbindin OS=Homo sapiens OX=9606 GN=DTNBP1 PE=1 SV=1" "0.000" "False" "32.637" "19" "6" "9" "6" "351" "39.5" "4.67" "33.54" "6" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04440" "84062" "ENSG00000047579" "DTNBP1" "A8K3V3; hsa:84062; Q5THY3; Q5THY4; Q96EV8; Q96NV2; Q9H0U2; Q9H3J5" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "0.951" "0.981" "0.952" "0.923" "0.928" "1.037" "0.959" "1.025" "1.132" "574.7" "546.3" "563.9" "547.3" "530.5" "533.2" "596.1" "551.0" "589.0" "650.5" "" "" "" "" "" "" "" "" "" "" "509.7" "452.6" "492.0" "409.3" "442.4" "489.8" "503.8" "455.4" "540.2" "650.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766016140567224551" "False" "High" "IsMasterProtein" "Q08380" "Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1" "0.000" "False" "32.634" "11" "5" "6" "5" "585" "65.3" "5.27" "22.66" "5" "cell adhesion;stress response;transport;signal transduction" "non-structural extracellular;other membranes;other cell component" "other molecular function" "Pf00530, Pf07707" "3959" "ENSG00000108679" "LGALS3BP" "hsa:3959; Q08380; Q7M4S0; Q9UCH8; Q9UCH9; Q9UCI0" "Platelet degranulation" "Network map of SARS-CoV-2 signaling pathway; 11p11.2 copy number variation syndrome" "3" "0" "1.023" "0.963" "1.069" "1.046" "1.043" "0.933" "0.976" "0.908" "0.565" "352.8" "360.7" "339.7" "377.2" "369.0" "367.8" "329.1" "344.4" "320.2" "199.2" "" "" "" "" "" "" "" "" "" "" "312.8" "298.8" "296.4" "282.1" "307.7" "337.9" "278.1" "284.6" "293.7" "199.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "487381900913570393" "False" "High" "IsMasterProtein" "Q9H8Y8" "Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3" "0.000" "False" "32.581" "15" "6" "10" "6" "452" "47.1" "4.82" "38.69" "6" "cell organization and biogenesis;stress response;other biological processes" "other membranes;ER/Golgi" "" "Pf04495" "26003" "ENSG00000115806" "GORASP2" "B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4" "Golgi Cisternae Pericentriolar Stack Reorganization" "" "1" "0" "0.947" "0.956" "0.895" "0.888" "0.917" "0.848" "0.700" "0.901" "3.451" "391.5" "370.8" "374.4" "350.4" "347.7" "359.0" "332.1" "274.1" "352.7" "1351.1" "" "" "" "" "" "" "" "" "" "" "347.2" "307.2" "326.7" "262.0" "290.0" "329.8" "280.7" "226.5" "323.5" "1351.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7745810489150015985" "False" "High" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "0.000" "False" "32.575" "28" "6" "11" "5" "243" "27.2" "7.30" "38.93" "6" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; Sphingolipid de novo biosynthesis; RAC2 GTPase cycle; RHOD GTPase cycle" "Ciliary landscape" "7" "0" "0.925" "0.992" "0.895" "0.850" "0.943" "0.873" "0.961" "0.926" "0.399" "1351.3" "1250.3" "1341.1" "1209.7" "1147.9" "1274.4" "1179.0" "1297.9" "1251.2" "539.0" "" "" "" "" "" "" "" "" "" "" "1198.3" "1035.7" "1170.2" "904.7" "957.2" "1170.7" "996.5" "1072.8" "1147.5" "539.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "32.573" "24" "6" "6" "5" "286" "32.4" "6.55" "24.23" "6" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "0" "0.959" "0.936" "1.011" "0.928" "0.985" "1.010" "0.938" "0.939" "0.526" "583.0" "559.3" "545.8" "589.7" "541.2" "574.3" "588.6" "547.0" "547.2" "306.6" "" "" "" "" "" "" "" "" "" "" "517.0" "463.3" "476.2" "441.0" "451.3" "527.6" "497.5" "452.1" "501.8" "306.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786307772961790223" "False" "High" "IsMasterProtein" "Q6QNY1" "Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1" "0.000" "False" "32.540" "34" "5" "6" "5" "142" "16.0" "4.86" "28.49" "5" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf10046" "282991" "ENSG00000196072" "BLOC1S2" "B4DQV2; hsa:282991; Q5W040; Q6QNY1; Q8WUI8" "" "" "0" "0" "1.090" "0.996" "0.962" "1.042" "1.068" "1.036" "0.992" "1.082" "0.796" "903.8" "985.4" "900.3" "869.9" "942.0" "964.9" "936.2" "896.1" "977.9" "719.4" "" "" "" "" "" "" "" "" "" "" "801.5" "816.2" "785.5" "650.5" "785.5" "886.4" "791.2" "740.7" "896.9" "719.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "32.510" "11" "11" "12" "11" "1008" "102.3" "8.06" "29.89" "11" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 regulates neuronal receptors and channels" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "3" "0" "1.023" "0.950" "1.120" "1.058" "0.977" "1.118" "1.117" "1.065" "0.659" "376.7" "385.3" "357.8" "421.8" "398.4" "368.0" "421.0" "420.8" "401.3" "248.1" "" "" "" "" "" "" "" "" "" "" "334.0" "319.2" "312.2" "315.5" "332.2" "338.1" "355.8" "347.8" "368.1" "248.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377093586219491132" "False" "High" "IsMasterProtein" "Q5VW36" "Focadhesin OS=Homo sapiens OX=9606 GN=FOCAD PE=1 SV=2" "0.000" "False" "32.504" "4" "8" "8" "8" "1801" "199.9" "6.62" "27.64" "8" "other biological processes" "cytosol;other cell component" "" "Pf11229, Pf12530" "54914" "ENSG00000188352" "FOCAD" "D3DRJ9; hsa:54914; Q5VW36; Q6ZME1; Q8IZG0; Q96JM8; Q96MS9; Q9BVF3; Q9NX87" "" "" "0" "0" "1.071" "1.003" "1.094" "1.080" "1.001" "1.022" "1.046" "0.951" "0.763" "496.9" "532.3" "498.5" "543.4" "536.8" "497.2" "507.9" "519.9" "472.6" "379.3" "" "" "" "" "" "" "" "" "" "" "440.6" "440.9" "435.0" "406.4" "447.6" "456.7" "429.3" "429.7" "433.5" "379.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4714570572578111777" "False" "High" "IsMasterProtein" "Q86YS6" "Ras-related protein Rab-43 OS=Homo sapiens OX=9606 GN=RAB43 PE=1 SV=1" "0.000" "False" "32.496" "31" "7" "11" "6" "212" "23.3" "5.64" "37.36" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "339122" "ENSG00000172780" "RAB43" "A8K4P9; E9PBQ0; hsa:339122; Q86YS6" "RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network" "" "2" "0" "0.971" "0.803" "0.858" "0.921" "0.933" "0.917" "0.848" "0.655" "0.532" "136.8" "132.8" "109.9" "117.3" "125.9" "127.6" "125.4" "116.0" "89.6" "72.7" "" "" "" "" "" "" "" "" "" "" "121.3" "110.0" "95.9" "87.7" "105.0" "117.2" "105.9" "95.9" "82.2" "72.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "32.491" "41" "5" "21" "4" "79" "9.7" "8.94" "65.21" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "Small cell lung cancer" "3" "1" "0.988" "0.960" "1.018" "1.019" "1.007" "0.933" "1.007" "1.023" "0.852" "2064.6" "2040.3" "1981.4" "2101.2" "2104.4" "2078.5" "1927.2" "2078.6" "2111.2" "1758.2" "" "" "" "" "" "" "" "" "" "" "1830.8" "1690.1" "1728.8" "1571.4" "1754.8" "1909.3" "1628.8" "1718.1" "1936.3" "1758.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "32.489" "11" "7" "7" "7" "754" "84.9" "6.90" "25.78" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "29" "0" "0.977" "0.987" "0.957" "1.007" "1.008" "0.883" "0.843" "0.922" "1.460" "595.5" "582.1" "587.5" "569.8" "599.6" "600.2" "525.8" "501.8" "549.3" "869.3" "" "" "" "" "" "" "" "" "" "" "528.1" "482.2" "512.7" "426.2" "500.0" "551.4" "444.4" "414.8" "503.7" "869.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261913870359179685" "False" "High" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "0.000" "False" "32.434" "4" "9" "9" "9" "2243" "254.3" "6.74" "27.04" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "Neutrophil degranulation" "" "1" "0" "1.081" "1.009" "1.087" "0.991" "0.987" "1.002" "0.940" "0.959" "1.409" "589.3" "636.8" "594.5" "640.8" "583.9" "581.4" "590.4" "553.8" "565.0" "830.1" "" "" "" "" "" "" "" "" "" "" "522.6" "527.5" "518.8" "479.3" "486.9" "534.1" "499.0" "457.8" "518.2" "830.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "32.386" "36" "9" "10" "9" "225" "25.7" "9.25" "30.53" "9" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "0.928" "0.842" "0.816" "0.809" "0.758" "0.788" "0.766" "0.898" "1.294" "970.0" "900.2" "816.7" "791.3" "785.0" "735.2" "764.8" "743.4" "871.3" "1255.3" "" "" "" "" "" "" "" "" "" "" "860.1" "745.7" "712.7" "591.8" "654.6" "675.4" "646.4" "614.4" "799.1" "1255.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.000" "False" "32.342" "27" "6" "7" "6" "209" "23.8" "7.39" "27.82" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "Glycosphingolipid transport" "" "1" "0" "0.996" "0.988" "0.988" "1.018" "1.015" "1.109" "1.062" "1.022" "0.766" "960.7" "956.7" "949.7" "949.2" "978.4" "974.7" "1065.3" "1020.8" "982.3" "735.5" "" "" "" "" "" "" "" "" "" "" "852.0" "792.5" "828.6" "709.9" "815.9" "895.3" "900.4" "843.7" "900.9" "735.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7919741535000260072" "False" "High" "IsMasterProtein" "Q96K80" "Zinc finger CCCH domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZC3H10 PE=1 SV=1" "0.000" "False" "32.331" "17" "7" "7" "7" "434" "46.0" "7.64" "22.98" "7" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "84872" "ENSG00000135482" "ZC3H10" "hsa:84872; Q96K80" "" "" "0" "0" "0.950" "0.988" "0.922" "0.931" "1.052" "0.870" "0.881" "0.885" "0.555" "1297.2" "1232.4" "1281.1" "1196.2" "1208.1" "1365.2" "1128.9" "1142.6" "1147.8" "720.3" "" "" "" "" "" "" "" "" "" "" "1150.4" "1020.8" "1117.8" "894.6" "1007.4" "1254.1" "954.1" "944.5" "1052.7" "720.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.000" "False" "32.303" "39" "5" "21" "5" "107" "11.7" "10.32" "74.17" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "13" "0" "1.014" "0.997" "1.003" "1.050" "1.074" "1.061" "1.159" "1.128" "0.610" "2608.9" "2645.6" "2602.1" "2616.7" "2738.2" "2803.2" "2768.3" "3023.1" "2941.8" "1591.9" "" "" "" "" "" "" "" "" "" "" "2313.5" "2191.5" "2270.4" "1957.0" "2283.3" "2575.1" "2339.6" "2498.8" "2698.1" "1591.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214058643654551286" "False" "High" "IsMasterProtein" "Q9Y3Y2" "Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2" "0.000" "False" "32.290" "17" "3" "5" "3" "248" "26.4" "12.23" "22.96" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf13865" "26097" "ENSG00000160679" "CHTOP" "D3DV55; hsa:26097; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0; Q9Y3Y2" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "1.146" "1.070" "1.041" "1.155" "1.035" "0.938" "0.914" "1.065" "1.125" "617.6" "707.7" "661.0" "642.9" "713.2" "639.1" "579.1" "564.8" "657.8" "694.6" "" "" "" "" "" "" "" "" "" "" "547.7" "586.3" "576.8" "480.8" "594.8" "587.1" "489.4" "466.8" "603.3" "694.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "32.267" "20" "4" "7" "4" "281" "31.9" "8.73" "26.97" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "7q11.23 copy number variation syndrome" "3" "0" "1.019" "0.978" "0.992" "1.049" "1.117" "1.023" "1.017" "0.917" "0.773" "658.0" "670.4" "643.4" "652.8" "690.2" "735.3" "672.8" "669.3" "603.5" "508.5" "" "" "" "" "" "" "" "" "" "" "583.5" "555.3" "561.4" "488.2" "575.6" "675.4" "568.6" "553.2" "553.5" "508.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "34707929049350531" "False" "High" "IsMasterProtein" "P51151" "Ras-related protein Rab-9A OS=Homo sapiens OX=9606 GN=RAB9A PE=1 SV=1" "0.000" "False" "32.236" "27" "5" "9" "5" "201" "22.8" "5.47" "30.80" "5" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "9367" "ENSG00000123595" "RAB9A" "A8K390; hsa:9367; P51151; Q6ICN1" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle" "Ebola virus infection in host; Measles virus infection" "6" "0" "1.036" "1.022" "1.024" "1.048" "1.053" "1.008" "1.001" "0.957" "0.526" "1044.7" "1082.3" "1067.7" "1070.1" "1094.8" "1100.1" "1052.8" "1045.7" "999.9" "549.4" "" "" "" "" "" "" "" "" "" "" "926.4" "896.5" "931.7" "800.3" "912.9" "1010.6" "889.8" "864.4" "917.1" "549.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4054510205684443302" "False" "High" "IsMasterProtein" "Q9Y6X8" "Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1" "0.000" "False" "32.224" "7" "5" "6" "5" "837" "92.3" "6.86" "26.02" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf18387" "22882" "ENSG00000178764" "ZHX2" "hsa:22882; Q9Y6X8" "" "" "0" "0" "0.989" "0.920" "0.988" "1.004" "0.931" "1.012" "0.785" "0.873" "3.027" "339.9" "336.3" "312.7" "336.0" "341.1" "316.5" "344.1" "266.9" "296.7" "1029.0" "" "" "" "" "" "" "" "" "" "" "301.4" "278.6" "272.8" "251.3" "284.5" "290.7" "290.8" "220.7" "272.1" "1029.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "32.209" "32" "5" "26" "5" "139" "15.3" "9.99" "78.41" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "Ciliary landscape" "3" "0" "0.954" "1.008" "0.990" "1.035" "1.032" "1.004" "1.027" "1.006" "0.477" "1645.1" "1569.0" "1658.2" "1628.6" "1703.4" "1698.1" "1651.1" "1689.9" "1654.4" "785.2" "" "" "" "" "" "" "" "" "" "" "1458.8" "1299.7" "1446.9" "1218.0" "1420.4" "1559.9" "1395.4" "1396.8" "1517.3" "785.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4000962258629935056" "False" "High" "IsMasterProtein" "P62847" "Small ribosomal subunit protein eS24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "0.000" "False" "32.166" "30" "4" "7" "4" "133" "15.4" "10.78" "25.12" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.004" "1.011" "0.989" "1.040" "1.077" "1.004" "1.147" "0.977" "1.433" "474.7" "476.6" "479.8" "469.4" "493.6" "511.1" "476.4" "544.5" "464.0" "680.3" "" "" "" "" "" "" "" "" "" "" "420.9" "394.8" "418.7" "351.1" "411.6" "469.5" "402.6" "450.1" "425.5" "680.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7756363839167913105" "False" "High" "IsMasterProtein" "Q13490" "Baculoviral IAP repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=BIRC2 PE=1 SV=2" "0.000" "False" "32.072" "11" "7" "7" "7" "618" "69.9" "6.70" "24.28" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00653, Pf13920, Pf21290" "329" "ENSG00000110330" "BIRC2" "B4E026; hsa:329; Q13490; Q16516; Q4TTG0" "Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; Regulation of necroptotic cell death; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Apoptotic cleavage of cellular proteins" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; Photodynamic therapy-induced NF-kB survival signaling; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma" "22" "0" "1.026" "1.027" "1.093" "1.075" "1.066" "0.980" "1.018" "0.969" "0.977" "641.5" "658.3" "659.0" "700.9" "689.7" "683.9" "629.0" "653.1" "621.4" "626.6" "" "" "" "" "" "" "" "" "" "" "568.9" "545.3" "575.0" "524.2" "575.1" "628.3" "531.6" "539.8" "569.9" "626.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.000" "False" "32.067" "18" "7" "9" "7" "394" "44.2" "9.09" "27.16" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Reversal of alkylation damage by DNA dioxygenases" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "0.936" "0.992" "0.970" "0.959" "1.089" "1.016" "0.968" "1.009" "1.192" "411.9" "385.7" "408.8" "399.4" "394.9" "448.5" "418.6" "398.6" "415.6" "491.0" "" "" "" "" "" "" "" "" "" "" "365.3" "319.5" "356.7" "298.7" "329.3" "412.0" "353.8" "329.5" "381.1" "491.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3800161177308876944" "False" "High" "IsMasterProtein" "Q8NEM2" "SHC SH2 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SHCBP1 PE=1 SV=3" "0.000" "False" "32.064" "14" "8" "8" "8" "672" "75.6" "4.75" "27.34" "8" "signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13229" "79801" "ENSG00000171241" "SHCBP1" "hsa:79801; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.924" "0.875" "1.122" "1.030" "0.801" "1.032" "0.687" "0.875" "5.819" "171.1" "158.1" "149.6" "192.0" "176.2" "137.0" "176.5" "117.5" "149.6" "995.3" "" "" "" "" "" "" "" "" "" "" "151.7" "131.0" "130.6" "143.6" "147.0" "125.9" "149.1" "97.1" "137.2" "995.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7816371347857019055" "False" "High" "IsMasterProtein" "Q8WW22" "DnaJ homolog subfamily A member 4 OS=Homo sapiens OX=9606 GN=DNAJA4 PE=1 SV=1" "0.000" "False" "32.031" "15" "6" "9" "6" "397" "44.8" "7.59" "28.08" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "55466" "ENSG00000140403" "DNAJA4" "E9PDM9; hsa:55466; Q6AW87; Q8N5Z4; Q8N7P2; Q8WW22" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "" "1" "0" "0.898" "0.840" "0.886" "0.846" "0.714" "0.797" "0.816" "0.910" "1.153" "604.9" "543.2" "508.0" "536.2" "511.6" "432.2" "482.2" "493.9" "550.6" "697.7" "" "" "" "" "" "" "" "" "" "" "536.4" "450.0" "443.2" "401.0" "426.6" "397.0" "407.5" "408.2" "505.0" "697.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6054246856873050357" "False" "High" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "0.000" "False" "31.985" "20" "8" "9" "8" "436" "49.2" "8.81" "28.85" "8" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "T cell receptor and co-stimulatory signaling; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Hereditary leiomyomatosis and renal cell carcinoma pathway; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; GNAQ pathways in port-wine stain; EPO receptor signaling; DNA damage response (only ATM dependent)" "23" "0" "1.096" "1.122" "1.019" "1.080" "1.125" "1.299" "1.185" "1.261" "1.729" "399.8" "438.2" "448.7" "407.5" "431.7" "449.7" "519.3" "473.9" "504.2" "691.3" "" "" "" "" "" "" "" "" "" "" "354.5" "363.0" "391.5" "304.8" "360.0" "413.1" "438.9" "391.7" "462.4" "691.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255183124898333384" "False" "High" "IsMasterProtein" "Q9Y6G5" "COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1" "0.000" "False" "31.929" "24" "4" "7" "4" "202" "23.0" "6.54" "32.09" "4" "" "nucleus;other cell component" "" "Pf07258, Pf21672" "51397" "ENSG00000145781" "COMMD10" "D3DT07; hsa:51397; Q9P077; Q9Y6G5" "Neddylation" "" "1" "0" "1.092" "1.100" "1.035" "1.077" "1.109" "1.099" "1.094" "0.983" "0.908" "767.5" "838.0" "844.3" "794.2" "827.0" "851.4" "843.4" "839.4" "754.6" "696.8" "" "" "" "" "" "" "" "" "" "" "680.6" "694.1" "736.7" "593.9" "689.6" "782.1" "712.8" "693.8" "692.1" "696.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.000" "False" "31.903" "27" "5" "8" "5" "215" "24.9" "5.55" "32.04" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Neutrophil degranulation; Condensation of Prometaphase Chromosomes; KEAP1-NFE2L2 pathway; Regulation of PTEN stability and activity; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "21" "0" "0.962" "0.976" "0.974" "0.999" "1.041" "1.011" "0.941" "0.927" "1.777" "710.5" "683.4" "693.2" "692.3" "709.8" "739.6" "718.2" "668.4" "658.6" "1262.7" "" "" "" "" "" "" "" "" "" "" "630.1" "566.1" "604.9" "517.7" "591.9" "679.4" "607.0" "552.5" "604.0" "1262.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "31.895" "11" "7" "8" "6" "633" "68.0" "9.94" "28.73" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "" "6" "0" "0.985" "1.052" "1.020" "1.003" "0.941" "0.952" "0.879" "1.045" "2.941" "361.5" "356.0" "380.1" "368.8" "362.5" "340.1" "344.1" "317.8" "377.7" "1062.9" "" "" "" "" "" "" "" "" "" "" "320.5" "294.9" "331.6" "275.8" "302.3" "312.4" "290.8" "262.7" "346.4" "1062.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7072278322173443531" "False" "High" "IsMasterProtein" "Q8N371" "Bifunctional peptidase and arginyl-hydroxylase JMJD5 OS=Homo sapiens OX=9606 GN=KDM8 PE=1 SV=1" "0.000" "False" "31.834" "18" "6" "6" "6" "416" "47.2" "5.80" "21.60" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13621" "79831" "ENSG00000155666" "KDM8" "B4DLU9; hsa:79831; Q6VAK5; Q8N371; Q9H8B1" "Protein hydroxylation" "" "1" "0" "1.027" "0.957" "0.980" "1.038" "0.931" "0.992" "1.031" "1.029" "0.707" "262.1" "269.0" "250.7" "256.8" "271.9" "244.0" "259.9" "270.3" "269.6" "185.4" "" "" "" "" "" "" "" "" "" "" "232.4" "222.8" "218.8" "192.0" "226.7" "224.1" "219.6" "223.4" "247.3" "185.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3690320084066520669" "False" "High" "IsMasterProtein" "Cont_P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "0.000" "True" "31.807" "13" "9" "9" "1" "564" "60.0" "8.00" "30.22" "9" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "Formation of the cornified envelope" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147334840207979337" "False" "High" "IsMasterProtein" "Q8WUN7" "Ubiquitin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=UBTD2 PE=1 SV=2" "0.000" "False" "31.798" "23" "4" "5" "4" "234" "26.2" "5.67" "23.53" "4" "" "other cell component" "" "Pf00240, Pf16455" "92181" "ENSG00000168246" "UBTD2" "hsa:92181; Q8TDQ3; Q8WUN7" "" "" "0" "0" "1.005" "0.933" "1.130" "0.975" "0.917" "0.965" "1.013" "0.975" "0.693" "387.3" "389.4" "361.5" "437.9" "377.7" "355.0" "373.8" "392.4" "377.5" "268.2" "" "" "" "" "" "" "" "" "" "" "343.5" "322.6" "315.4" "327.5" "314.9" "326.1" "315.9" "324.3" "346.2" "268.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "31.781" "8" "6" "8" "3" "917" "102.3" "6.05" "29.85" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Glycolysis" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "7" "0" "0.998" "0.846" "1.259" "1.064" "0.831" "1.036" "0.599" "1.070" "6.617" "125.2" "125.0" "106.0" "157.6" "133.2" "104.0" "129.7" "75.0" "133.9" "828.6" "" "" "" "" "" "" "" "" "" "" "111.0" "103.5" "92.5" "117.9" "111.1" "95.6" "109.6" "62.0" "122.8" "828.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "31.749" "14" "10" "10" "5" "590" "62.3" "7.74" "33.16" "10" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "Formation of the cornified envelope; Type I hemidesmosome assembly" "" "3" "2" "0.832" "2.278" "1.606" "0.752" "1.843" "1.207" "0.818" "0.916" "1.296" "707.4" "588.5" "1611.3" "1135.9" "531.8" "1303.8" "853.8" "579.0" "648.1" "916.9" "" "" "" "" "" "" "" "" "" "" "627.3" "487.5" "1406.0" "849.5" "443.4" "1197.7" "721.6" "478.6" "594.4" "916.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "31.689" "54" "5" "6" "5" "102" "11.8" "8.68" "23.67" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "Neddylation" "" "1" "0" "1.168" "1.057" "1.283" "1.018" "0.875" "0.779" "1.034" "0.999" "0.828" "236.3" "275.9" "249.7" "303.1" "240.5" "206.8" "184.0" "244.4" "236.1" "195.6" "" "" "" "" "" "" "" "" "" "" "209.5" "228.6" "217.9" "226.7" "200.5" "190.0" "155.5" "202.0" "216.6" "195.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7529838149184307642" "False" "High" "IsMasterProtein" "P04066" "Tissue alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA1 PE=1 SV=4" "0.000" "False" "31.669" "13" "7" "9" "7" "466" "53.7" "6.84" "28.83" "7" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01120, Pf16757" "2517" "ENSG00000179163" "FUCA1" "B2RBG3; hsa:2517; P04066; Q14334; Q14335; Q3LID0; Q8NAC2" "Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway" "p53 transcriptional gene network" "3" "0" "0.918" "0.962" "0.922" "0.902" "1.018" "0.964" "0.961" "0.914" "0.485" "596.4" "547.2" "573.8" "549.9" "538.2" "607.0" "574.7" "573.4" "545.2" "289.5" "" "" "" "" "" "" "" "" "" "" "528.9" "453.3" "500.7" "411.2" "448.8" "557.6" "485.7" "474.0" "500.0" "289.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7437759637941576864" "False" "High" "IsMasterProtein" "Q92597" "Protein NDRG1 OS=Homo sapiens OX=9606 GN=NDRG1 PE=1 SV=1" "0.000" "False" "31.647" "11" "3" "5" "3" "394" "42.8" "5.82" "24.32" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03096" "10397" "ENSG00000104419" "NDRG1" "B3KR80; B7Z446; hsa:10397; O15207; Q6IBG2; Q92597; Q9NYR6; Q9UK29" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "Androgen receptor network in prostate cancer; VEGFA-VEGFR2 signaling; Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Intracellular trafficking proteins involved in CMT neuropathy; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "8" "0" "1.211" "1.007" "1.042" "1.038" "0.984" "1.156" "1.151" "1.010" "0.756" "287.4" "348.0" "289.5" "299.4" "298.2" "282.7" "332.3" "331.0" "290.2" "217.4" "" "" "" "" "" "" "" "" "" "" "254.9" "288.3" "252.6" "223.9" "248.7" "259.7" "280.9" "273.6" "266.1" "217.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "High" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.000" "False" "31.603" "16" "5" "9" "5" "382" "40.4" "7.96" "34.44" "5" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "0.926" "0.953" "0.939" "0.918" "0.963" "0.876" "0.938" "0.916" "0.579" "480.8" "445.1" "458.0" "451.5" "441.2" "463.0" "421.2" "451.2" "440.3" "278.5" "" "" "" "" "" "" "" "" "" "" "426.4" "368.7" "399.6" "337.6" "367.9" "425.3" "356.0" "372.9" "403.8" "278.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915758716299824080" "False" "High" "IsMasterProtein" "Q06787" "Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1" "0.000" "False" "31.590" "11" "7" "7" "6" "632" "71.1" "7.42" "27.35" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16098, Pf17904, Pf18336" "2332" "ENSG00000102081" "FMR1" "A6NNH4; D3DWT0; D3DWT1; D3DWT2; G8JL90; hsa:2332; Q06787; Q16578; Q5PQZ6; Q99054" "" "Ovarian infertility; Serotonin and anxiety; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; Primary ovarian insufficiency" "7" "0" "0.991" "0.953" "0.951" "0.947" "1.000" "0.971" "0.979" "0.998" "0.526" "976.9" "968.2" "930.9" "929.2" "925.5" "976.5" "949.0" "955.9" "975.4" "514.2" "" "" "" "" "" "" "" "" "" "" "866.3" "802.0" "812.3" "694.9" "771.7" "897.0" "802.0" "790.2" "894.6" "514.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557682221437211922" "False" "High" "IsMasterProtein" "Q9Y6Q9" "Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1" "0.000" "False" "31.589" "5" "6" "6" "5" "1424" "155.2" "7.47" "22.18" "6" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "8202" "ENSG00000124151" "NCOA3" "A4LAZ5; hsa:8202; Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; Q9Y6Q9" "Estrogen-dependent gene expression; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; MAPK6/MAPK4 signaling" "Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway; Rubinstein-Taybi syndrome 1" "11" "1" "1.019" "0.987" "0.996" "0.963" "0.979" "0.889" "0.867" "0.891" "1.714" "659.2" "671.5" "650.5" "656.9" "634.8" "645.3" "586.3" "571.6" "587.3" "1130.0" "" "" "" "" "" "" "" "" "" "" "584.6" "556.3" "567.6" "491.3" "529.3" "592.8" "495.5" "472.5" "538.6" "1130.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "31.585" "28" "8" "9" "8" "246" "28.0" "8.44" "29.92" "8" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RSV-host interactions; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "" "5" "0" "0.899" "0.795" "0.821" "0.733" "0.662" "0.693" "0.892" "0.961" "0.498" "1192.9" "1072.1" "948.9" "979.0" "873.8" "790.1" "827.1" "1064.3" "1146.8" "594.6" "" "" "" "" "" "" "" "" "" "" "1057.8" "888.1" "828.0" "732.2" "728.7" "725.8" "699.1" "879.8" "1051.8" "594.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7638543548033193713" "False" "High" "IsMasterProtein" "Q00765" "Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3" "0.000" "False" "31.574" "23" "5" "11" "5" "189" "21.5" "8.10" "37.57" "5" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf03134" "7905" "ENSG00000129625" "REEP5" "B7Z681; D3DT04; hsa:7905; Q00765; Q04198; Q5QGT0; Q9BWH9" "" "" "0" "0" "0.955" "0.895" "0.911" "0.864" "0.947" "0.943" "0.883" "0.856" "0.777" "989.4" "944.5" "885.2" "900.9" "854.6" "936.5" "932.6" "873.2" "847.2" "768.9" "" "" "" "" "" "" "" "" "" "" "877.4" "782.4" "772.3" "673.8" "712.6" "860.3" "788.2" "721.7" "777.0" "768.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4849374493010714997" "False" "High" "IsMasterProtein" "Q92673" "Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2" "0.000" "False" "31.564" "3" "6" "7" "6" "2214" "248.3" "5.55" "23.34" "6" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00041, Pf00057, Pf00058, Pf15901, Pf15902" "6653" "ENSG00000137642" "SORL1" "B2RNX7; hsa:6653; Q92673; Q92856" "Amyloid fiber formation" "" "1" "0" "1.169" "1.261" "1.219" "1.162" "1.133" "1.153" "1.117" "1.319" "0.885" "443.5" "518.3" "559.4" "540.7" "515.6" "502.6" "511.4" "495.3" "585.0" "392.7" "" "" "" "" "" "" "" "" "" "" "393.3" "429.3" "488.1" "404.4" "429.9" "461.7" "432.2" "409.4" "536.5" "392.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2743146227967072639" "False" "High" "IsMasterProtein" "Q86WP2" "Vasculin OS=Homo sapiens OX=9606 GN=GPBP1 PE=1 SV=1" "0.000" "False" "31.539" "12" "6" "7" "6" "473" "53.3" "7.05" "22.24" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15337" "65056" "ENSG00000062194" "GPBP1" "A6NKW3; hsa:65056; Q6NSH6; Q86WP2; Q9H0D4; Q9H785; Q9NSN4" "" "" "0" "0" "0.920" "0.933" "1.034" "0.929" "1.003" "0.940" "0.955" "1.004" "0.671" "147.0" "135.2" "137.2" "152.0" "136.5" "147.4" "138.2" "140.3" "147.5" "98.7" "" "" "" "" "" "" "" "" "" "" "130.3" "112.0" "119.7" "113.7" "113.9" "135.4" "116.8" "116.0" "135.3" "98.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3451849306749892991" "False" "High" "IsMasterProtein" "P49459" "Ubiquitin-conjugating enzyme E2 A OS=Homo sapiens OX=9606 GN=UBE2A PE=1 SV=2" "0.000" "False" "31.521" "31" "3" "5" "2" "152" "17.3" "5.15" "28.06" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7319" "ENSG00000077721" "UBE2A" "A6NFE9; A6NGR2; A6NMF5; B2R7R9; D3DWI1; hsa:7319; P49459; Q4TTG1; Q96FX4" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "3" "1" "1.013" "1.012" "0.982" "1.086" "1.098" "0.994" "1.094" "1.086" "0.726" "720.2" "729.5" "728.9" "706.9" "782.5" "790.9" "716.0" "787.9" "781.8" "523.1" "" "" "" "" "" "" "" "" "" "" "638.7" "604.2" "636.0" "528.7" "652.5" "726.6" "605.2" "651.3" "717.0" "523.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "High" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.000" "False" "31.515" "16" "7" "8" "7" "429" "48.6" "9.58" "27.96" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "0.896" "0.909" "0.836" "0.829" "0.816" "0.526" "0.564" "0.618" "0.507" "1784.9" "1598.8" "1623.3" "1492.7" "1479.2" "1455.8" "938.2" "1006.1" "1103.2" "904.1" "" "" "" "" "" "" "" "" "" "" "1582.8" "1324.4" "1416.4" "1116.4" "1233.5" "1337.3" "792.9" "831.6" "1011.8" "904.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "31.496" "46" "3" "30" "3" "69" "7.8" "10.70" "87.98" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.022" "0.945" "1.068" "1.055" "1.076" "1.008" "0.980" "0.939" "0.415" "1492.7" "1526.2" "1411.2" "1593.9" "1574.1" "1605.6" "1504.8" "1463.0" "1401.9" "619.6" "" "" "" "" "" "" "" "" "" "" "1323.7" "1264.2" "1231.4" "1192.0" "1312.6" "1474.9" "1271.8" "1209.3" "1285.8" "619.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3688625229951110619" "False" "High" "IsMasterProtein" "Cont_P02538" "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" "0.000" "True" "31.412" "13" "9" "9" "1" "564" "60.0" "8.00" "30.21" "9" "cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3853" "ENSG00000205420" "KRT6A" "A0A0S2Z428; A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4" "Formation of the cornified envelope" "Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes" "5" "1" "0.445" "2.979" "1.086" "1.086" "0.721" "2.395" "0.574" "0.761" "0.893" "205.6" "91.5" "612.3" "223.3" "223.2" "148.2" "492.3" "117.9" "156.3" "183.5" "" "" "" "" "" "" "" "" "" "" "182.3" "75.8" "534.2" "167.0" "186.1" "136.1" "416.0" "97.5" "143.4" "183.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "31.358" "41" "7" "12" "7" "147" "16.8" "4.74" "39.64" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Activation of the pre-replicative complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "16" "0" "0.925" "0.968" "0.896" "0.855" "0.860" "0.842" "0.946" "0.919" "0.665" "1393.0" "1288.2" "1348.4" "1247.7" "1191.4" "1197.3" "1173.3" "1317.3" "1280.6" "926.4" "" "" "" "" "" "" "" "" "" "" "1235.3" "1067.1" "1176.5" "933.1" "993.4" "1099.9" "991.6" "1088.8" "1174.5" "926.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2510158146736873084" "False" "High" "IsMasterProtein" "P29084" "Transcription initiation factor IIE subunit beta OS=Homo sapiens OX=9606 GN=GTF2E2 PE=1 SV=1" "0.000" "False" "31.357" "27" "8" "8" "8" "291" "33.0" "9.66" "30.36" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf02186, Pf18121" "2961" "ENSG00000197265" "GTF2E2" "D3DSV2; P29084; Q9H2B9" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "0.977" "1.034" "0.990" "1.010" "1.011" "0.888" "0.629" "0.962" "5.694" "978.7" "955.9" "1011.5" "968.9" "988.1" "989.8" "868.9" "615.1" "941.7" "5572.5" "" "" "" "" "" "" "" "" "" "" "867.9" "791.8" "882.5" "724.6" "823.9" "909.3" "734.3" "508.4" "863.7" "5572.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227008394942671266" "False" "High" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "0.000" "False" "31.320" "12" "11" "13" "10" "820" "95.5" "9.55" "35.84" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "1.066" "1.006" "1.112" "1.004" "1.052" "1.058" "1.043" "1.028" "0.579" "671.5" "716.1" "675.6" "747.0" "674.3" "706.3" "710.7" "700.1" "690.2" "388.8" "" "" "" "" "" "" "" "" "" "" "595.5" "593.2" "589.5" "558.7" "562.2" "648.9" "600.7" "578.7" "633.0" "388.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "31.289" "6" "8" "11" "5" "1147" "125.8" "9.55" "37.63" "8" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "0" "0.894" "0.948" "0.856" "0.803" "0.918" "0.824" "0.764" "0.954" "2.660" "1152.2" "1029.9" "1092.6" "986.5" "925.6" "1057.3" "949.1" "880.1" "1099.0" "3064.4" "" "" "" "" "" "" "" "" "" "" "1021.8" "853.1" "953.3" "737.8" "771.8" "971.3" "802.1" "727.4" "1008.0" "3064.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6536357785872288465" "False" "High" "IsMasterProtein" "P48723" "Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1" "0.000" "False" "31.268" "12" "5" "6" "5" "471" "51.9" "5.76" "22.58" "5" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00012" "6782" "ENSG00000155304" "HSPA13" "B2R616; hsa:6782; P48723; Q8NE40" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.987" "0.944" "1.184" "1.107" "1.002" "1.393" "1.413" "1.246" "1.204" "323.3" "319.0" "305.2" "382.7" "357.8" "323.9" "450.5" "456.8" "403.0" "389.3" "" "" "" "" "" "" "" "" "" "" "286.7" "264.2" "266.3" "286.2" "298.4" "297.6" "380.8" "377.5" "369.6" "389.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209477172492729631" "False" "High" "IsMasterProtein" "Q9UPN6" "SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1" "0.000" "False" "31.243" "7" "9" "12" "6" "1271" "140.4" "8.29" "41.44" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "22828" "ENSG00000213079" "SCAF8" "B7Z888; hsa:22828; Q5TBU6; Q6NSK3; Q9BQN8; Q9BX43; Q9UPN6" "" "" "0" "0" "1.012" "1.006" "1.054" "1.047" "0.939" "0.920" "0.889" "0.907" "1.178" "305.9" "309.5" "307.9" "322.5" "320.4" "287.4" "281.5" "271.8" "277.5" "360.4" "" "" "" "" "" "" "" "" "" "" "271.3" "256.4" "268.7" "241.2" "267.2" "264.0" "237.9" "224.7" "254.5" "360.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3797665255168145849" "False" "High" "IsMasterProtein" "P46087" "28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "0.000" "False" "31.234" "12" "9" "11" "9" "812" "89.2" "9.23" "32.00" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Imatinib and chronic myeloid leukemia" "3" "0" "0.990" "0.921" "0.997" "0.943" "0.929" "0.947" "0.967" "0.902" "0.422" "1330.9" "1318.2" "1226.4" "1327.5" "1254.7" "1236.8" "1259.8" "1286.6" "1200.0" "561.0" "" "" "" "" "" "" "" "" "" "" "1180.2" "1091.9" "1070.1" "992.8" "1046.2" "1136.1" "1064.7" "1063.5" "1100.6" "561.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7087591643624783243" "False" "High" "IsMasterProtein" "Q9H3C7" "Gametogenetin-binding protein 2 OS=Homo sapiens OX=9606 GN=GGNBP2 PE=1 SV=1" "0.000" "False" "31.219" "13" "6" "8" "6" "697" "79.0" "6.38" "25.71" "6" "developmental processes;other biological processes" "nucleus;other cell component" "" "" "79893" "ENSG00000275099; ENSG00000278311" "GGNBP2" "B2RPK7; hsa:79893; Q96T90; Q9GZR8; Q9H3C7; Q9H767" "" "17q12 copy number variation syndrome" "1" "0" "0.949" "1.072" "0.869" "0.872" "1.037" "0.978" "0.926" "1.099" "0.557" "793.6" "753.4" "850.6" "690.0" "691.8" "823.2" "775.9" "734.9" "872.3" "441.7" "" "" "" "" "" "" "" "" "" "" "703.8" "624.1" "742.2" "516.0" "576.9" "756.2" "655.8" "607.5" "800.0" "441.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563058972091496350" "False" "High" "IsMasterProtein" "P80723" "Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2" "0.000" "False" "31.201" "28" "4" "4" "4" "227" "22.7" "4.63" "18.46" "4" "developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05466" "10409" "ENSG00000176788" "BASP1" "B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5" "RHOF GTPase cycle" "" "1" "0" "0.843" "0.776" "0.843" "0.765" "0.676" "0.681" "0.849" "0.844" "0.432" "689.2" "580.9" "534.5" "581.2" "527.3" "466.0" "469.0" "585.4" "581.8" "297.5" "" "" "" "" "" "" "" "" "" "" "611.2" "481.2" "466.4" "434.7" "439.7" "428.1" "396.4" "483.9" "533.6" "297.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-629472087456424791" "False" "High" "IsMasterProtein" "Q09472" "Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2" "0.000" "False" "31.103" "4" "10" "11" "5" "2414" "264.0" "8.50" "35.52" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "2033" "ENSG00000100393" "EP300" "B1AKC2; hsa:2033; Q09472" "Regulation of RUNX3 expression and activity; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Transcriptional regulation of granulopoiesis; Attenuation phase; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NGF-stimulated transcription; Heme signaling; SUMOylation of transcription cofactors; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Metalloprotease DUBs; Regulation of TP53 Activity through Methylation; NFE2L2 regulating anti-oxidant/detoxification enzymes; NOTCH1 Intracellular Domain Regulates Transcription; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling; NFE2L2 regulating MDR associated enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; CD209 (DC-SIGN) signaling; Polo-like kinase mediated events; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; RUNX3 regulates p14-ARF; Regulation of gene expression by Hypoxia-inducible Factor; PI5P Regulates TP53 Acetylation; NOTCH2 intracellular domain regulates transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; IL-4 signaling pathway; Wnt signaling pathway and pluripotency; Prion disease pathway; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; CAMKK2 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; CCL18 signaling pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Urotensin-II-mediated signaling pathway; Pathophysiological roles of DUX4 in FSHD1; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "91" "0" "0.930" "1.019" "0.626" "0.866" "1.044" "0.863" "0.936" "0.986" "1.209" "703.7" "654.5" "717.0" "440.3" "609.7" "734.8" "607.0" "659.0" "694.1" "850.9" "" "" "" "" "" "" "" "" "" "" "624.1" "542.1" "625.6" "329.3" "508.4" "675.0" "513.0" "544.7" "636.6" "850.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3393024407889637945" "False" "High" "IsMasterProtein" "P63027" "Vesicle-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=VAMP2 PE=1 SV=3" "0.000" "False" "31.101" "28" "2" "4" "2" "116" "12.7" "8.13" "22.86" "2" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6844" "ENSG00000220205" "VAMP2" "hsa:6844; P19065; P63027; Q9BUC2" "Sensory processing of sound by inner hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Glutamate Neurotransmitter Release Cycle; Regulation of insulin secretion; Insulin processing; Cargo recognition for clathrin-mediated endocytosis; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Vasopressin-regulated water reabsorption; Sudden infant death syndrome (SIDS) susceptibility pathways" "28" "0" "1.036" "0.978" "1.104" "1.126" "1.072" "1.206" "1.171" "1.118" "0.807" "302.4" "313.2" "295.7" "334.0" "340.6" "324.1" "364.8" "354.1" "338.1" "244.1" "" "" "" "" "" "" "" "" "" "" "268.2" "259.5" "258.0" "249.8" "284.0" "297.7" "308.3" "292.7" "310.1" "244.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991678768207076864" "False" "High" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.000" "False" "31.094" "14" "8" "9" "7" "606" "64.9" "9.32" "28.70" "8" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "Platelet degranulation" "" "1" "0" "1.016" "1.000" "1.005" "0.931" "0.941" "1.016" "0.486" "1.061" "9.306" "447.2" "454.3" "447.1" "449.6" "416.2" "420.6" "454.2" "217.4" "474.3" "4161.3" "" "" "" "" "" "" "" "" "" "" "396.6" "376.3" "390.1" "336.3" "347.1" "386.4" "383.9" "179.7" "435.0" "4161.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "31.094" "15" "9" "12" "9" "537" "59.0" "5.83" "40.85" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "" "2" "0" "1.062" "1.058" "1.037" "1.073" "1.101" "1.009" "1.056" "0.955" "0.870" "1915.3" "2033.5" "2026.9" "1986.8" "2055.1" "2108.8" "1932.8" "2021.7" "1829.0" "1665.4" "" "" "" "" "" "" "" "" "" "" "1698.4" "1684.4" "1768.6" "1485.9" "1713.7" "1937.2" "1633.5" "1671.0" "1677.4" "1665.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278234146555232268" "False" "High" "IsMasterProtein" "Q96BK5" "PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2" "0.000" "False" "31.090" "20" "5" "5" "5" "328" "37.0" "9.60" "21.84" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01585" "54984" "ENSG00000254093; ENSG00000284764" "PINX1" "B2R9B1; hsa:54984; Q548A5; Q6QWG9; Q7Z7J8; Q96BK5; Q96QD7; Q9HBU7; Q9NWW2" "" "" "0" "0" "0.993" "0.957" "0.977" "1.026" "0.991" "1.055" "1.034" "1.005" "0.712" "524.2" "520.3" "501.5" "512.1" "537.8" "519.6" "553.1" "542.0" "527.0" "373.4" "" "" "" "" "" "" "" "" "" "" "464.8" "431.0" "437.6" "383.0" "448.4" "477.4" "467.5" "448.0" "483.4" "373.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2429714834335380006" "False" "High" "IsMasterProtein" "P40818" "Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1" "0.000" "False" "31.075" "7" "7" "8" "7" "1118" "127.4" "8.51" "27.94" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf00581, Pf08969, Pf20625" "9101" "ENSG00000138592" "USP8" "B4DKA8; hsa:9101; P40818; Q2TB31; Q7Z3U2; Q86VA0; Q8IWI7" "Negative regulation of MET activity; Ub-specific processing proteases; Downregulation of ERBB2:ERBB3 signaling; Regulation of FZD by ubiquitination" "EGF/EGFR signaling pathway; Male infertility" "6" "0" "0.966" "0.979" "1.030" "0.975" "0.933" "1.032" "0.689" "1.092" "7.179" "169.4" "163.6" "165.8" "174.5" "165.1" "158.1" "174.8" "116.7" "185.1" "1216.2" "" "" "" "" "" "" "" "" "" "" "150.2" "135.5" "144.7" "130.5" "137.7" "145.2" "147.7" "96.4" "169.7" "1216.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.000" "False" "31.040" "26" "7" "12" "7" "291" "33.1" "7.25" "38.14" "7" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "0.907" "0.928" "0.976" "0.963" "0.836" "0.980" "0.953" "1.013" "0.547" "576.3" "522.8" "534.9" "562.5" "554.9" "481.5" "564.6" "549.2" "583.6" "315.3" "" "" "" "" "" "" "" "" "" "" "511.1" "433.0" "466.7" "420.7" "462.7" "442.3" "477.2" "454.0" "535.3" "315.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2473277628257978921" "False" "High" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "0.000" "False" "31.000" "4" "7" "8" "7" "1749" "195.9" "6.73" "29.91" "7" "transport" "cytosol;nucleus" "other molecular function" "Pf10487, Pf21093, Pf21094" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "Vpr-mediated nuclear import of PICs; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.842" "0.803" "0.854" "0.758" "0.766" "0.941" "0.513" "0.858" "7.961" "175.9" "148.1" "141.3" "150.3" "133.3" "134.7" "165.6" "90.2" "150.9" "1400.5" "" "" "" "" "" "" "" "" "" "" "156.0" "122.7" "123.3" "112.4" "111.1" "123.7" "140.0" "74.6" "138.4" "1400.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "High" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.000" "False" "30.988" "12" "6" "10" "6" "607" "70.3" "6.11" "35.34" "6" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "1.090" "1.020" "1.092" "1.031" "1.066" "1.038" "0.881" "0.961" "3.111" "366.1" "399.1" "373.3" "399.9" "377.6" "390.4" "380.2" "322.7" "352.0" "1139.0" "" "" "" "" "" "" "" "" "" "" "324.6" "330.6" "325.7" "299.1" "314.9" "358.6" "321.3" "266.7" "322.8" "1139.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "High" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.000" "False" "30.962" "13" "7" "7" "7" "591" "64.4" "8.76" "26.04" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "5" "0" "0.960" "0.904" "0.950" "0.868" "0.842" "0.879" "0.674" "0.845" "4.344" "338.6" "325.1" "306.2" "321.9" "293.8" "285.0" "297.6" "228.4" "286.2" "1471.1" "" "" "" "" "" "" "" "" "" "" "300.3" "269.3" "267.2" "240.7" "245.0" "261.8" "251.5" "188.8" "262.5" "1471.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3605806557374244366" "False" "High" "IsMasterProtein" "Q99766" "ATP synthase subunit s, mitochondrial OS=Homo sapiens OX=9606 GN=DMAC2L PE=1 SV=4" "0.000" "False" "30.936" "37" "7" "7" "7" "200" "23.2" "7.90" "26.20" "7" "other metabolic processes;transport" "other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "" "27109" "ENSG00000125375" "DMAC2L" "A0A2R8YDJ1; A0A5K1VW60; A8K1U3; D9N156; hsa:27109; Q8WWX3; Q96F77; Q99766" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "1.046" "1.009" "1.014" "1.038" "1.029" "0.996" "1.030" "0.998" "0.886" "917.3" "959.8" "925.9" "930.3" "951.9" "943.8" "913.8" "944.8" "915.8" "812.9" "" "" "" "" "" "" "" "" "" "" "813.4" "795.0" "807.9" "695.7" "793.8" "867.0" "772.3" "780.9" "839.9" "812.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864324901755663317" "False" "High" "IsMasterProtein" "Q8TAP9" "M-phase-specific PLK1-interacting protein OS=Homo sapiens OX=9606 GN=MPLKIP PE=1 SV=1" "0.000" "False" "30.928" "27" "3" "4" "3" "179" "19.1" "10.23" "23.25" "3" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf15502" "136647" "ENSG00000168303" "MPLKIP" "hsa:136647; Q8TAP9" "" "" "0" "0" "0.933" "0.903" "0.901" "0.902" "0.974" "0.918" "0.984" "0.900" "0.561" "237.6" "221.8" "214.6" "214.2" "214.4" "231.5" "218.2" "233.8" "213.9" "133.3" "" "" "" "" "" "" "" "" "" "" "210.7" "183.8" "187.3" "160.2" "178.8" "212.6" "184.4" "193.3" "196.2" "133.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564362200897381814" "False" "High" "IsMasterProtein" "Q9P2N5" "RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2" "0.000" "False" "30.927" "6" "6" "7" "6" "1060" "118.6" "9.19" "26.43" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00076, Pf00642, Pf01480" "54439" "ENSG00000091009" "RBM27" "hsa:54439; Q8IYW9; Q9P2N5" "" "" "0" "0" "0.928" "0.935" "0.956" "0.944" "0.905" "0.911" "0.847" "0.868" "1.743" "420.8" "390.3" "393.4" "402.4" "397.0" "380.7" "383.4" "356.6" "365.4" "733.6" "" "" "" "" "" "" "" "" "" "" "373.2" "323.3" "343.2" "300.9" "331.1" "349.7" "324.0" "294.7" "335.1" "733.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.000" "False" "30.914" "13" "6" "9" "6" "457" "49.8" "8.41" "32.81" "6" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "RET signaling" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "4" "0" "1.195" "0.899" "0.990" "1.024" "0.919" "0.930" "0.987" "0.948" "2.037" "202.8" "242.3" "182.4" "200.8" "207.7" "186.4" "188.6" "200.2" "192.4" "413.1" "" "" "" "" "" "" "" "" "" "" "179.9" "200.7" "159.2" "150.2" "173.2" "171.2" "159.4" "165.5" "176.4" "413.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.000" "False" "30.906" "12" "5" "7" "5" "420" "47.0" "8.73" "23.82" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "rRNA modification in the mitochondrion" "" "1" "0" "0.886" "0.885" "1.065" "0.940" "0.852" "0.963" "0.938" "0.861" "0.463" "455.2" "403.4" "402.8" "484.6" "428.1" "387.9" "438.2" "426.9" "392.1" "210.7" "" "" "" "" "" "" "" "" "" "" "403.7" "334.2" "351.5" "362.4" "357.0" "356.3" "370.3" "352.8" "359.6" "210.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588774124192242024" "False" "High" "IsMasterProtein" "P54132" "RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1" "0.000" "False" "30.894" "4" "5" "7" "4" "1417" "158.9" "7.49" "24.26" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382, Pf16124, Pf16202, Pf16204" "641" "ENSG00000197299" "BLM" "hsa:641; P54132; Q52M96" "Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Processive synthesis on the C-strand of the telomere" "Primary ovarian insufficiency" "18" "0" "1.140" "1.050" "1.039" "1.027" "1.016" "1.101" "1.173" "1.427" "1.550" "320.4" "365.3" "336.2" "333.0" "329.0" "325.4" "352.8" "375.6" "457.1" "496.6" "" "" "" "" "" "" "" "" "" "" "284.1" "302.6" "293.4" "249.0" "274.4" "299.0" "298.2" "310.5" "419.3" "496.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1100607226643900304" "False" "High" "IsMasterProtein" "Q9UHR4" "BAR/IMD domain-containing adapter protein 2-like 1 OS=Homo sapiens OX=9606 GN=BAIAP2L1 PE=1 SV=2" "0.000" "False" "30.865" "20" "10" "11" "10" "511" "56.8" "8.68" "39.33" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf08397, Pf14604" "55971" "ENSG00000006453" "BAIAP2L1" "A4D268; hsa:55971; Q75L21; Q75L22; Q96CV4; Q9H5F5; Q9UHR4; Q9Y2M8" "RAC2 GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle; RAC1 GTPase cycle" "" "4" "0" "1.289" "1.174" "1.131" "1.172" "1.200" "1.134" "1.068" "1.091" "0.794" "733.0" "944.9" "860.3" "828.9" "859.0" "879.6" "831.6" "783.0" "799.5" "581.7" "" "" "" "" "" "" "" "" "" "" "650.0" "782.7" "750.7" "619.9" "716.3" "808.1" "702.8" "647.2" "733.3" "581.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5539226776075582677" "False" "High" "IsMasterProtein" "Q5TC82" "Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1" "0.000" "False" "30.783" "7" "6" "7" "6" "1133" "125.7" "7.27" "28.16" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf14634, Pf18386, Pf21206" "149041" "ENSG00000135870" "RC3H1" "B3KVK1; hsa:149041; Q5TC82; Q5W180; Q5W181; Q8IVE6; Q8N9V1" "" "" "0" "0" "0.872" "0.830" "0.989" "1.004" "0.878" "1.010" "0.965" "0.737" "0.693" "160.6" "140.0" "133.3" "158.9" "161.3" "141.0" "162.2" "155.0" "118.4" "111.3" "" "" "" "" "" "" "" "" "" "" "142.4" "116.0" "116.3" "118.8" "134.5" "129.5" "137.1" "128.1" "108.6" "111.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "High" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.000" "False" "30.733" "19" "5" "7" "5" "383" "43.5" "5.81" "25.27" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "1.048" "1.046" "1.124" "1.100" "1.125" "1.090" "1.060" "0.995" "0.687" "512.8" "537.2" "536.4" "576.5" "563.8" "576.9" "558.9" "543.5" "510.0" "352.1" "" "" "" "" "" "" "" "" "" "" "454.7" "445.0" "468.0" "431.1" "470.1" "529.9" "472.4" "449.2" "467.8" "352.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-987846664266598251" "False" "High" "IsMasterProtein" "Q9NS87" "Kinesin-like protein KIF15 OS=Homo sapiens OX=9606 GN=KIF15 PE=1 SV=1" "0.000" "False" "30.717" "6" "8" "9" "8" "1388" "160.1" "6.00" "30.76" "8" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00225, Pf15908" "56992" "ENSG00000163808; ENSG00000280610" "KIF15" "hsa:56992; Q17RV9; Q69YL6; Q96JX7; Q9H280; Q9NS87" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "Gastric cancer network 1" "4" "0" "0.818" "0.804" "0.775" "0.769" "0.674" "0.785" "0.359" "0.751" "6.645" "184.7" "151.1" "148.4" "143.1" "142.0" "124.5" "145.0" "66.4" "138.8" "1227.2" "" "" "" "" "" "" "" "" "" "" "163.8" "125.2" "129.5" "107.0" "118.4" "114.4" "122.5" "54.9" "127.3" "1227.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251688870276858346" "False" "High" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "0.000" "False" "30.713" "13" "5" "8" "4" "385" "42.0" "9.69" "26.62" "5" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "1.024" "0.899" "0.960" "0.941" "0.819" "0.854" "0.805" "0.952" "2.385" "404.7" "414.3" "363.9" "388.5" "380.9" "331.6" "345.8" "325.7" "385.2" "965.3" "" "" "" "" "" "" "" "" "" "" "358.9" "343.2" "317.5" "290.5" "317.6" "304.6" "292.2" "269.2" "353.3" "965.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8556034775710589228" "False" "High" "IsMasterProtein" "Q8TF74" "WAS/WASL-interacting protein family member 2 OS=Homo sapiens OX=9606 GN=WIPF2 PE=1 SV=1" "0.000" "False" "30.707" "18" "7" "7" "7" "440" "46.3" "10.93" "25.75" "7" "" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf02205" "147179" "ENSG00000171475" "WIPF2" "A8K0L3; hsa:147179; Q658J8; Q71RE1; Q8TE44; Q8TF74" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle" "" "6" "0" "0.927" "1.020" "1.019" "0.956" "1.029" "0.943" "0.980" "0.902" "0.634" "207.7" "192.6" "211.8" "211.6" "198.5" "213.7" "195.9" "203.5" "187.4" "131.7" "" "" "" "" "" "" "" "" "" "" "184.2" "159.5" "184.8" "158.3" "165.5" "196.3" "165.6" "168.2" "171.9" "131.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076533743620825156" "False" "High" "IsMasterProtein" "Q02080" "Myocyte-specific enhancer factor 2B OS=Homo sapiens OX=9606 GN=MEF2B PE=1 SV=2" "0.000" "False" "30.702" "18" "6" "7" "6" "365" "38.6" "9.48" "23.72" "6" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319" "100271849; 4207" "ENSG00000213999" "MEF2B" "A0AV80; B4DVH7; B7ZVY1; G5E9M1; hsa:100271849; hsa:4207; Q02080" "Myogenesis" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Gastrin signaling pathway" "7" "0" "0.974" "0.898" "1.052" "1.035" "0.964" "0.988" "0.906" "0.939" "3.048" "329.6" "321.0" "296.1" "346.7" "341.2" "317.7" "325.5" "298.6" "309.7" "1004.6" "" "" "" "" "" "" "" "" "" "" "292.3" "265.9" "258.4" "259.3" "284.6" "291.8" "275.1" "246.8" "284.0" "1004.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "30.698" "30" "3" "8" "3" "128" "14.8" "9.19" "28.93" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.067" "0.998" "1.117" "1.103" "1.045" "1.115" "1.075" "0.988" "0.769" "656.0" "699.8" "654.5" "733.0" "723.4" "685.3" "731.1" "704.9" "648.2" "504.2" "" "" "" "" "" "" "" "" "" "" "581.7" "579.7" "571.1" "548.2" "603.3" "629.5" "617.9" "582.7" "594.4" "504.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "High" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.000" "False" "30.681" "17" "3" "6" "3" "223" "25.4" "5.52" "25.01" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "1.047" "0.892" "1.142" "1.022" "0.980" "1.171" "0.834" "0.981" "5.143" "462.0" "484.0" "412.3" "527.5" "472.2" "452.7" "541.0" "385.5" "453.3" "2376.1" "" "" "" "" "" "" "" "" "" "" "409.7" "400.9" "359.8" "394.5" "393.8" "415.8" "457.3" "318.7" "415.8" "2376.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5894079024390586831" "False" "High" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "0.000" "False" "30.628" "20" "8" "9" "5" "371" "43.7" "9.92" "30.33" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.020" "1.060" "0.912" "1.037" "0.964" "1.044" "1.038" "1.130" "1.924" "204.0" "208.1" "216.2" "186.1" "211.5" "196.7" "213.0" "211.8" "230.4" "392.5" "" "" "" "" "" "" "" "" "" "" "180.9" "172.4" "188.6" "139.2" "176.4" "180.6" "180.0" "175.1" "211.3" "392.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1015618648752571383" "False" "High" "IsMasterProtein" "P55210" "Caspase-7 OS=Homo sapiens OX=9606 GN=CASP7 PE=1 SV=1" "0.000" "False" "30.571" "20" "5" "7" "5" "303" "34.3" "6.07" "27.92" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00656" "840" "ENSG00000165806" "CASP7" "B4DQU7; B5BU45; D3DRB8; hsa:840; P55210; Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0" "Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase-mediated cleavage of cytoskeletal proteins" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Allograft rejection; Parkinson's disease pathway; Oncostatin M signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Hepatitis C and hepatocellular carcinoma; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Acute viral myocarditis; Nonalcoholic fatty liver disease; Host-pathogen interaction of human coronaviruses - apoptosis; 3q29 copy number variation syndrome; Complement system in neuronal development and plasticity; Alzheimer's disease" "27" "0" "1.086" "1.198" "1.206" "1.168" "1.101" "1.182" "1.106" "1.126" "0.838" "540.0" "586.3" "646.9" "651.0" "630.7" "594.3" "638.2" "597.4" "607.9" "452.5" "" "" "" "" "" "" "" "" "" "" "478.8" "485.7" "564.5" "486.8" "525.9" "545.9" "539.4" "493.8" "557.6" "452.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6167412320153067815" "False" "High" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "0.000" "False" "30.542" "18" "6" "9" "6" "385" "42.2" "5.66" "33.73" "6" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Integrin cell surface interactions; Degradation of the extracellular matrix; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "10" "0" "1.088" "1.022" "0.962" "1.034" "0.961" "1.108" "0.976" "1.223" "0.679" "621.4" "676.1" "635.0" "598.0" "642.7" "597.1" "688.3" "606.2" "760.0" "421.7" "" "" "" "" "" "" "" "" "" "" "551.0" "560.0" "554.1" "447.2" "535.9" "548.5" "581.7" "501.1" "697.1" "421.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1984767701943514611" "False" "High" "IsMasterProtein" "Q9NQS1" "Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1" "0.000" "False" "30.498" "15" "5" "8" "5" "362" "38.5" "4.98" "24.13" "5" "other biological processes" "other membranes;cytosol;other cell component" "" "" "57099" "ENSG00000169857" "AVEN" "hsa:57099; Q9NQS1" "Regulation of the apoptosome activity" "" "2" "0" "1.000" "0.987" "1.025" "1.001" "1.055" "0.941" "1.000" "1.042" "0.813" "744.5" "744.6" "734.7" "763.1" "745.0" "785.5" "700.2" "744.8" "776.0" "605.1" "" "" "" "" "" "" "" "" "" "" "660.2" "616.8" "641.0" "570.7" "621.3" "721.6" "591.8" "615.6" "711.7" "605.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6875111383431957192" "False" "High" "IsMasterProtein" "Q8IYW5" "E3 ubiquitin-protein ligase RNF168 OS=Homo sapiens OX=9606 GN=RNF168 PE=1 SV=1" "0.000" "False" "30.487" "13" "7" "7" "7" "571" "65.0" "7.96" "27.30" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097" "165918" "ENSG00000163961" "RNF168" "hsa:165918; Q8IYW5; Q8NA67; Q96NS4" "Processing of DNA double-strand break ends; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "8" "0" "0.939" "0.884" "0.890" "0.862" "0.857" "0.754" "0.782" "0.843" "0.979" "698.5" "656.0" "617.6" "621.9" "602.0" "598.7" "526.6" "546.3" "588.7" "683.8" "" "" "" "" "" "" "" "" "" "" "619.4" "543.4" "538.8" "465.1" "502.0" "550.0" "445.1" "451.6" "539.9" "683.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157210626844435621" "False" "High" "IsMasterProtein" "Q8IUI4" "Putative protein SNX29P2 OS=Homo sapiens OX=9606 GN=SNX29P2 PE=5 SV=2" "0.000" "False" "30.446" "29" "5" "6" "4" "249" "27.2" "4.94" "26.62" "5" "" "" "" "" "" "" "SNX29P2" "Q8IUI4" "" "" "0" "1" "1.161" "1.104" "1.085" "1.095" "1.070" "0.960" "0.891" "0.966" "2.256" "427.2" "495.8" "471.6" "463.6" "467.9" "456.9" "410.1" "380.5" "412.7" "963.9" "" "" "" "" "" "" "" "" "" "" "378.8" "410.7" "411.5" "346.7" "390.2" "419.7" "346.6" "314.5" "378.5" "963.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8117558468974038429" "False" "High" "IsMasterProtein" "Q96Q11" "CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2" "0.000" "False" "30.442" "17" "9" "11" "9" "434" "50.1" "8.10" "36.65" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01743, Pf12627" "51095" "ENSG00000072756" "TRNT1" "A8K2Z6; B7WP13; C9JKA2; hsa:51095; Q8ND57; Q96Q11; Q9BS97; Q9Y362" "tRNA processing in the nucleus; tRNA processing in the mitochondrion" "" "2" "0" "0.928" "0.959" "0.841" "0.832" "0.955" "0.846" "0.790" "0.882" "1.846" "1266.3" "1175.6" "1213.7" "1065.5" "1054.0" "1209.6" "1070.9" "1000.3" "1117.2" "2337.5" "" "" "" "" "" "" "" "" "" "" "1122.9" "973.8" "1059.0" "796.8" "878.9" "1111.1" "905.1" "826.8" "1024.6" "2337.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7765133988428364561" "False" "High" "IsMasterProtein" "Q58WW2" "DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6 PE=1 SV=1" "0.000" "False" "30.414" "11" "8" "8" "8" "860" "96.2" "5.27" "28.42" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55827" "ENSG00000143164" "DCAF6" "A2A295; B4DNB8; hsa:55827; Q58WW2; Q7L8I0; Q8IXH3; Q8TB19" "Neddylation" "" "1" "0" "1.068" "1.011" "1.132" "1.053" "1.030" "1.000" "0.987" "0.920" "0.745" "433.1" "462.6" "438.0" "490.1" "456.1" "446.1" "433.1" "427.6" "398.3" "322.8" "" "" "" "" "" "" "" "" "" "" "384.1" "383.2" "382.1" "366.5" "380.3" "409.8" "366.0" "353.5" "365.3" "322.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.000" "False" "30.392" "21" "7" "10" "5" "362" "41.4" "9.28" "39.03" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "HATs acetylate histones" "Pathways affected in adenoid cystic carcinoma" "2" "2" "1.002" "1.007" "0.992" "0.980" "1.009" "0.931" "0.894" "0.936" "2.092" "1041.7" "1044.3" "1049.5" "1033.4" "1020.4" "1051.4" "969.7" "931.6" "974.5" "2179.0" "" "" "" "" "" "" "" "" "" "" "923.7" "865.0" "915.7" "772.8" "850.8" "965.8" "819.5" "770.0" "893.7" "2179.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.000" "False" "30.391" "39" "5" "11" "5" "118" "12.7" "7.30" "33.92" "5" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "0.973" "1.008" "1.005" "1.034" "1.044" "1.032" "1.057" "0.881" "0.466" "1367.4" "1330.6" "1378.1" "1373.8" "1413.7" "1427.3" "1411.0" "1444.8" "1204.1" "637.0" "" "" "" "" "" "" "" "" "" "" "1212.5" "1102.2" "1202.4" "1027.4" "1178.8" "1311.1" "1192.5" "1194.3" "1104.3" "637.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.000" "False" "30.370" "18" "8" "9" "8" "465" "52.8" "6.70" "32.08" "8" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "Protein hydroxylation; HDMs demethylate histones" "" "2" "0" "0.892" "0.809" "0.947" "0.859" "0.898" "1.021" "0.946" "0.910" "0.909" "889.3" "792.9" "719.9" "842.3" "764.2" "798.3" "908.3" "841.2" "809.6" "808.8" "" "" "" "" "" "" "" "" "" "" "788.7" "656.8" "628.1" "629.9" "637.2" "733.3" "767.6" "695.3" "742.6" "808.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4947084340596136770" "False" "High" "IsMasterProtein" "Q8TF05" "Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1" "0.000" "False" "30.349" "6" "4" "5" "4" "950" "106.9" "4.77" "19.96" "4" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "enzyme regulator activity" "Pf02985, Pf15017" "9989" "ENSG00000154845" "PPP4R1" "hsa:9989; Q8TF05; Q99774; Q9UNQ7" "" "16p11.2 proximal deletion syndrome" "1" "0" "0.886" "0.909" "1.010" "0.886" "0.834" "1.000" "0.942" "0.933" "2.255" "548.7" "486.0" "498.7" "554.1" "486.0" "457.6" "548.6" "516.7" "511.9" "1237.1" "" "" "" "" "" "" "" "" "" "" "486.5" "402.5" "435.2" "414.4" "405.2" "420.4" "463.7" "427.1" "469.5" "1237.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.000" "False" "30.343" "15" "5" "5" "5" "464" "49.9" "8.29" "22.25" "5" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "1.023" "1.020" "1.170" "1.044" "1.130" "1.133" "1.155" "0.996" "0.618" "267.2" "273.5" "272.5" "312.7" "278.9" "302.1" "302.8" "308.7" "266.3" "165.2" "" "" "" "" "" "" "" "" "" "" "237.0" "226.6" "237.8" "233.9" "232.6" "277.5" "255.9" "255.2" "244.2" "165.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "30.310" "24" "6" "10" "5" "238" "27.1" "4.42" "35.07" "6" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "" "2" "1" "0.994" "1.019" "0.997" "0.985" "0.988" "0.889" "0.881" "0.866" "0.717" "1351.6" "1344.1" "1377.6" "1347.9" "1331.3" "1335.4" "1201.8" "1191.1" "1170.7" "969.2" "" "" "" "" "" "" "" "" "" "" "1198.6" "1113.4" "1202.0" "1008.0" "1110.1" "1226.7" "1015.7" "984.5" "1073.7" "969.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1010665989767425721" "False" "High" "IsMasterProtein" "Q96CS3" "FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2" "0.000" "False" "30.302" "6" "2" "4" "2" "445" "52.6" "5.62" "20.14" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "23197" "ENSG00000113194" "FAF2" "hsa:23197; O94963; Q8IUF2; Q96CS3; Q9BRP2; Q9BVM7" "Neutrophil degranulation; RHOA GTPase cycle" "5q35 copy number variation" "3" "0" "1.057" "1.099" "1.075" "1.040" "1.151" "1.197" "1.194" "1.154" "0.665" "379.9" "401.7" "417.5" "408.3" "395.1" "437.2" "454.7" "453.7" "438.4" "252.6" "" "" "" "" "" "" "" "" "" "" "336.8" "332.7" "364.3" "305.4" "329.4" "401.6" "384.3" "375.0" "402.0" "252.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196363809325094679" "False" "High" "IsMasterProtein" "Q9HCU8" "DNA polymerase delta subunit 4 OS=Homo sapiens OX=9606 GN=POLD4 PE=1 SV=1" "0.000" "False" "30.272" "33" "3" "7" "3" "107" "12.4" "6.77" "28.58" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf04081" "57804" "ENSG00000175482" "POLD4" "F5H506; hsa:57804; Q9HCU8" "Dual Incision in GG-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "25" "0" "0.932" "0.897" "1.045" "0.874" "0.861" "0.590" "0.587" "0.626" "0.451" "153.0" "142.6" "137.2" "160.0" "133.7" "131.7" "90.2" "89.9" "95.9" "69.0" "" "" "" "" "" "" "" "" "" "" "135.7" "118.2" "119.8" "119.6" "111.5" "121.0" "76.3" "74.3" "87.9" "69.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8017112882834387390" "False" "High" "IsMasterProtein" "Q9Y3C0" "WASH complex subunit 3 OS=Homo sapiens OX=9606 GN=WASHC3 PE=1 SV=1" "0.000" "False" "30.258" "26" "5" "6" "5" "194" "21.2" "4.46" "22.62" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10152" "51019" "ENSG00000120860" "WASHC3" "B2RC74; hsa:51019; Q53FF0; Q6IAI4; Q96QK0; Q9Y3C0" "" "" "0" "0" "1.037" "1.022" "1.083" "1.075" "0.955" "1.042" "0.957" "1.039" "1.050" "279.1" "289.5" "285.2" "302.3" "299.9" "266.4" "290.7" "267.1" "290.1" "293.0" "" "" "" "" "" "" "" "" "" "" "247.5" "239.8" "248.8" "226.1" "250.1" "244.8" "245.7" "220.8" "266.1" "293.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.000" "False" "30.205" "5" "4" "5" "4" "1063" "118.4" "7.02" "20.47" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.076" "1.157" "1.252" "1.217" "1.107" "1.404" "1.335" "1.243" "1.490" "481.0" "517.6" "556.8" "602.3" "585.6" "532.7" "675.5" "642.0" "597.9" "716.8" "" "" "" "" "" "" "" "" "" "" "426.6" "428.8" "485.8" "450.4" "488.4" "489.4" "570.9" "530.7" "548.3" "716.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901597498303011274" "False" "High" "IsMasterProtein" "P14621" "Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2" "0.000" "False" "30.191" "62" "7" "13" "7" "99" "11.1" "9.50" "41.09" "7" "other metabolic processes" "" "other molecular function" "Pf00708" "98" "ENSG00000170634" "ACYP2" "hsa:98; P14621" "" "" "0" "0" "0.931" "0.969" "0.906" "0.861" "0.987" "0.918" "0.928" "0.894" "0.498" "1777.8" "1655.7" "1722.8" "1610.6" "1530.1" "1754.1" "1631.8" "1649.6" "1589.6" "884.7" "" "" "" "" "" "" "" "" "" "" "1576.5" "1371.5" "1503.2" "1204.5" "1275.9" "1611.4" "1379.1" "1363.5" "1457.9" "884.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6887775823956767803" "False" "High" "IsMasterProtein" "P25440" "Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2" "0.000" "False" "30.144" "6" "5" "6" "5" "801" "88.0" "9.09" "24.11" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf17035" "6046" "ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307" "BRD2" "A2AAU0; B0S7P0; B1AZT1; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4" "RUNX3 regulates p14-ARF" "" "1" "0" "1.142" "0.969" "1.265" "1.116" "0.912" "1.195" "0.854" "1.079" "4.208" "573.3" "654.8" "555.7" "725.5" "639.5" "522.9" "685.3" "489.8" "618.5" "2412.0" "" "" "" "" "" "" "" "" "" "" "508.4" "542.4" "484.9" "542.5" "533.3" "480.4" "579.1" "404.9" "567.2" "2412.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "30.112" "15" "8" "9" "8" "644" "74.4" "5.53" "38.84" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "1.019" "0.946" "1.079" "0.979" "0.925" "0.909" "0.611" "0.959" "6.346" "545.5" "556.0" "515.9" "588.5" "534.1" "504.6" "496.1" "333.4" "523.1" "3462.1" "" "" "" "" "" "" "" "" "" "" "483.8" "460.6" "450.2" "440.1" "445.4" "463.6" "419.3" "275.6" "479.7" "3462.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1665507599286513190" "False" "High" "IsMasterProtein" "P62873" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3" "0.000" "False" "30.093" "18" "6" "8" "1" "340" "37.4" "6.00" "26.08" "6" "cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "2782" "ENSG00000078369" "GNB1" "B1AJZ7; hsa:2782; P04697; P04901; P62873; Q1RMY8" "G alpha (i) signalling events; G alpha (z) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Adrenaline,noradrenaline inhibits insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon signaling in metabolic regulation; G alpha (q) signalling events; G alpha (12/13) signalling events; Olfactory Signaling Pathway; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; Sensory perception of sweet, bitter, and umami (glutamate) taste; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Inactivation, recovery and regulation of the phototransduction cascade; Activation of the phototransduction cascade" "Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; 1p36 copy number variation syndrome; Calcium regulation in cardiac cells; Estrogen signaling pathway" "45" "5" "1.096" "0.947" "0.979" "1.067" "1.108" "1.080" "0.985" "1.215" "0.917" "977.0" "1070.7" "924.8" "956.2" "1042.6" "1082.3" "1054.9" "962.1" "1186.7" "896.2" "" "" "" "" "" "" "" "" "" "" "866.4" "886.9" "806.9" "715.1" "869.4" "994.2" "891.5" "795.2" "1088.4" "896.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694948017889393545" "False" "High" "IsMasterProtein" "Q8N490" "Probable hydrolase PNKD OS=Homo sapiens OX=9606 GN=PNKD PE=1 SV=2" "0.000" "False" "30.079" "15" "4" "5" "4" "385" "42.8" "9.09" "25.24" "4" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00753, Pf16123" "25953" "ENSG00000127838" "PNKD" "A8K1F2; hsa:25953; Q8N490; Q96A48; Q9BU26; Q9NSX4; Q9ULN6; Q9Y4T1" "" "Mitochondrial complex IV assembly" "1" "0" "1.070" "1.061" "1.131" "1.038" "1.155" "1.143" "1.143" "1.162" "0.569" "271.6" "290.7" "288.0" "307.2" "281.8" "313.5" "310.5" "310.3" "315.5" "154.6" "" "" "" "" "" "" "" "" "" "" "240.8" "240.8" "251.3" "229.7" "235.0" "288.0" "262.4" "256.5" "289.3" "154.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "30.045" "25" "6" "12" "6" "231" "25.7" "6.84" "39.45" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "COPI-independent Golgi-to-ER retrograde traffic" "PAFAH1B1 copy number variation" "2" "0" "1.049" "0.992" "1.075" "0.999" "1.003" "1.228" "0.953" "1.091" "2.019" "428.4" "449.5" "425.0" "460.6" "427.7" "429.6" "525.8" "408.3" "467.3" "864.7" "" "" "" "" "" "" "" "" "" "" "379.9" "372.3" "370.9" "344.5" "356.7" "394.6" "444.4" "337.5" "428.5" "864.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.000" "False" "30.041" "19" "5" "6" "5" "261" "27.0" "6.54" "19.25" "5" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "Fatty acyl-CoA biosynthesis" "" "1" "0" "1.091" "1.060" "1.193" "1.061" "1.109" "1.053" "1.073" "1.024" "0.410" "451.3" "492.3" "478.5" "538.2" "478.9" "500.4" "475.1" "484.1" "462.1" "184.8" "" "" "" "" "" "" "" "" "" "" "400.2" "407.8" "417.5" "402.5" "399.4" "459.7" "401.6" "400.1" "423.8" "184.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "High" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.000" "False" "30.039" "52" "5" "10" "5" "75" "8.7" "5.45" "28.72" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "Regulation of actin cytoskeleton" "8" "0" "1.028" "1.045" "0.980" "1.010" "0.989" "1.032" "0.998" "0.975" "0.922" "813.2" "835.8" "849.5" "797.3" "821.6" "803.9" "839.4" "811.2" "792.5" "749.4" "" "" "" "" "" "" "" "" "" "" "721.1" "692.3" "741.2" "596.3" "685.1" "738.4" "709.4" "670.5" "726.8" "749.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1533138465656150959" "False" "High" "IsMasterProtein" "Q5VWQ0" "Lysine-specific demethylase 9 OS=Homo sapiens OX=9606 GN=RSBN1 PE=1 SV=2" "0.000" "False" "30.034" "8" "6" "7" "6" "802" "90.0" "8.60" "24.00" "6" "cell organization and biogenesis" "nucleus" "other molecular function" "" "54665" "ENSG00000081019" "RSBN1" "A8K937; hsa:54665; Q5VWQ0; Q6AI21; Q8TC33; Q9HA80; Q9NUP6" "" "" "0" "0" "1.035" "1.055" "1.089" "1.046" "1.011" "1.075" "1.045" "1.046" "0.729" "513.7" "531.5" "541.8" "559.2" "537.1" "519.3" "552.4" "536.9" "537.1" "374.2" "" "" "" "" "" "" "" "" "" "" "455.5" "440.3" "472.7" "418.2" "447.9" "477.1" "466.8" "443.8" "492.6" "374.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.000" "False" "30.012" "14" "4" "9" "4" "298" "34.8" "8.00" "24.72" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.952" "1.008" "1.042" "1.002" "1.102" "0.953" "1.057" "0.875" "0.591" "610.8" "581.7" "615.9" "636.8" "612.0" "672.9" "582.3" "645.9" "534.5" "361.1" "" "" "" "" "" "" "" "" "" "" "541.7" "481.8" "537.4" "476.2" "510.3" "618.1" "492.1" "533.9" "490.2" "361.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.000" "False" "30.007" "63" "6" "12" "6" "99" "10.9" "9.57" "37.92" "6" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "0.980" "0.986" "1.040" "0.951" "0.923" "1.037" "1.007" "1.015" "0.449" "1001.7" "982.1" "987.6" "1041.6" "952.6" "924.9" "1038.5" "1008.8" "1016.6" "450.2" "" "" "" "" "" "" "" "" "" "" "888.3" "813.6" "861.8" "779.0" "794.4" "849.7" "877.7" "833.9" "932.4" "450.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7653373487496169859" "False" "High" "IsMasterProtein" "Q4VC05" "B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1" "0.000" "False" "29.964" "30" "5" "7" "3" "210" "22.8" "5.14" "25.70" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "605" "ENSG00000110987" "BCL7A" "B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05" "" "" "0" "1" "0.968" "0.971" "0.976" "0.972" "0.966" "0.892" "0.894" "0.916" "1.040" "431.9" "418.2" "419.5" "421.5" "419.8" "417.1" "385.3" "385.9" "395.4" "449.2" "" "" "" "" "" "" "" "" "" "" "383.0" "346.4" "366.0" "315.2" "350.0" "383.2" "325.7" "319.0" "362.6" "449.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5250221047475229599" "False" "High" "IsMasterProtein" "Q7LBC6" "Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2" "0.000" "False" "29.955" "3" "6" "6" "6" "1761" "191.5" "7.18" "20.84" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "51780" "ENSG00000120733" "KDM3B" "A6H8X7; hsa:51780; Q7LBC6; Q9BVH6; Q9BW93; Q9BZ52; Q9NYF4; Q9UPS0" "HDMs demethylate histones" "Thermogenesis" "2" "0" "1.142" "0.966" "1.190" "0.987" "0.989" "1.037" "0.701" "0.908" "4.917" "258.5" "295.2" "249.6" "307.6" "255.1" "255.6" "268.0" "181.3" "234.6" "1270.9" "" "" "" "" "" "" "" "" "" "" "229.2" "244.5" "217.8" "230.0" "212.7" "234.8" "226.5" "149.9" "215.2" "1270.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "29.917" "15" "8" "9" "8" "477" "54.1" "7.24" "28.34" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Mitochondrial tRNA aminoacylation" "Ectoderm differentiation" "2" "0" "1.075" "1.159" "1.178" "1.238" "1.213" "1.916" "1.687" "1.650" "1.394" "429.2" "461.5" "497.4" "505.5" "531.4" "520.6" "822.5" "724.0" "708.3" "598.2" "" "" "" "" "" "" "" "" "" "" "380.6" "382.3" "434.0" "378.0" "443.2" "478.2" "695.2" "598.4" "649.6" "598.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "29.900" "19" "8" "8" "8" "392" "42.9" "7.09" "28.90" "8" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "" "2q37 copy number variation syndrome" "1" "0" "0.884" "0.800" "0.735" "0.706" "0.697" "0.691" "0.392" "0.729" "8.061" "403.9" "357.2" "323.0" "297.0" "285.2" "281.4" "278.9" "158.2" "294.5" "3255.7" "" "" "" "" "" "" "" "" "" "" "358.1" "295.9" "281.8" "222.1" "237.8" "258.5" "235.7" "130.7" "270.1" "3255.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773428691670053213" "False" "High" "IsMasterProtein" "P62834" "Ras-related protein Rap-1A OS=Homo sapiens OX=9606 GN=RAP1A PE=1 SV=1" "0.000" "False" "29.896" "27" "5" "8" "1" "184" "21.0" "6.67" "24.68" "5" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5906" "ENSG00000116473" "RAP1A" "hsa:5906; P10113; P62834" "Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; DNA repair pathways, full network; GDNF signaling; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "35" "0" "1.100" "1.070" "1.020" "1.097" "1.096" "1.076" "1.005" "1.343" "0.841" "150.2" "165.2" "160.8" "153.3" "164.8" "164.7" "161.6" "150.9" "201.8" "126.3" "" "" "" "" "" "" "" "" "" "" "133.2" "136.9" "140.3" "114.6" "137.4" "151.3" "136.6" "124.7" "185.0" "126.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114579132969382726" "False" "High" "IsMasterProtein" "Q7L266" "Isoaspartyl peptidase/L-asparaginase OS=Homo sapiens OX=9606 GN=ASRGL1 PE=1 SV=2" "0.000" "False" "29.885" "26" "7" "14" "7" "308" "32.0" "6.24" "44.16" "7" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01112" "80150" "ENSG00000162174" "ASRGL1" "B2R7Q0; hsa:80150; Q567Q4; Q6P1P0; Q7L266; Q8NI34; Q9H6F7" "Phenylalanine metabolism" "" "1" "0" "1.024" "0.980" "1.020" "0.999" "0.984" "1.073" "1.073" "1.111" "0.624" "610.0" "624.7" "597.7" "622.0" "609.2" "600.5" "654.3" "654.8" "677.9" "380.4" "" "" "" "" "" "" "" "" "" "" "540.9" "517.5" "521.5" "465.1" "508.0" "551.7" "552.9" "541.2" "621.8" "380.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "29.828" "13" "7" "7" "7" "621" "72.0" "8.70" "26.83" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.030" "0.969" "1.147" "1.117" "0.908" "1.046" "0.697" "1.037" "6.117" "536.8" "552.7" "520.1" "615.9" "599.4" "487.5" "561.8" "373.9" "556.5" "3284.0" "" "" "" "" "" "" "" "" "" "" "476.1" "457.8" "453.9" "460.6" "499.8" "447.8" "474.8" "309.1" "510.4" "3284.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.000" "False" "29.806" "10" "7" "8" "7" "739" "78.5" "9.23" "26.51" "7" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "" "2" "0" "0.896" "0.882" "0.781" "0.794" "0.858" "0.916" "0.826" "1.021" "1.233" "101.1" "90.6" "89.1" "79.0" "80.3" "86.8" "92.7" "83.5" "103.3" "124.7" "" "" "" "" "" "" "" "" "" "" "89.7" "75.1" "77.8" "59.1" "67.0" "79.7" "78.3" "69.0" "94.7" "124.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2544930509745837934" "False" "High" "IsMasterProtein" "P81877" "Single-stranded DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=SSBP2 PE=1 SV=2" "0.000" "False" "29.792" "11" "3" "7" "3" "361" "37.8" "6.64" "28.86" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04503" "23635" "ENSG00000145687" "SSBP2" "B2R5W1; B7Z1J2; B7Z2L9; B7Z665; D6RH18; E9PB74; E9PDA8; hsa:23635; P81877; Q8N2Q2; Q9BWW6; Q9Y4T7" "" "" "0" "0" "0.934" "0.869" "0.843" "0.790" "0.739" "0.675" "0.803" "0.954" "0.452" "723.0" "675.2" "628.4" "609.4" "571.4" "534.1" "487.9" "580.8" "689.5" "326.6" "" "" "" "" "" "" "" "" "" "" "641.1" "559.3" "548.3" "455.7" "476.5" "490.6" "412.3" "480.1" "632.4" "326.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "High" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.000" "False" "29.782" "30" "5" "7" "5" "192" "22.0" "5.73" "25.95" "5" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "1.111" "1.092" "1.062" "1.138" "1.031" "1.112" "0.801" "1.102" "6.088" "249.9" "277.7" "272.8" "265.4" "284.4" "257.7" "277.9" "200.2" "275.3" "1521.3" "" "" "" "" "" "" "" "" "" "" "221.6" "230.0" "238.0" "198.5" "237.2" "236.7" "234.9" "165.5" "252.5" "1521.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5259121706082363690" "False" "High" "IsMasterProtein" "Q6NS38" "DNA oxidative demethylase ALKBH2 OS=Homo sapiens OX=9606 GN=ALKBH2 PE=1 SV=1" "0.000" "False" "29.722" "17" "5" "8" "5" "261" "29.3" "9.66" "26.94" "5" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13532" "121642" "ENSG00000189046" "ALKBH2" "A4PET2; hsa:121642; Q5XLE3; Q6NS38" "ALKBH2 mediated reversal of alkylation damage" "Direct reversal repair" "2" "0" "1.027" "0.944" "1.111" "1.058" "1.055" "1.051" "0.898" "0.856" "1.169" "331.2" "340.0" "312.7" "368.1" "350.3" "349.5" "348.2" "297.4" "283.5" "387.1" "" "" "" "" "" "" "" "" "" "" "293.7" "281.7" "272.8" "275.3" "292.1" "321.1" "294.3" "245.8" "260.0" "387.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "29.720" "27" "9" "11" "9" "326" "37.8" "8.84" "31.35" "9" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "" "Pleural mesothelioma" "1" "0" "0.983" "0.900" "1.079" "0.963" "0.897" "1.001" "0.583" "0.975" "7.631" "528.7" "519.6" "476.0" "570.3" "509.2" "474.2" "529.1" "308.0" "515.7" "4034.2" "" "" "" "" "" "" "" "" "" "" "468.8" "430.4" "415.4" "426.5" "424.6" "435.6" "447.1" "254.6" "473.0" "4034.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.000" "False" "29.659" "24" "6" "7" "6" "233" "26.2" "5.74" "25.44" "6" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "9" "0" "1.044" "1.012" "1.031" "1.042" "1.062" "0.902" "0.838" "0.945" "2.827" "838.6" "875.9" "848.4" "864.5" "873.7" "890.4" "756.7" "702.9" "792.1" "2370.8" "" "" "" "" "" "" "" "" "" "" "743.6" "725.5" "740.3" "646.6" "728.6" "817.9" "639.6" "581.0" "726.5" "2370.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "29.621" "29" "5" "6" "5" "198" "21.8" "5.88" "25.14" "5" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "Neutrophil degranulation; Neddylation" "" "2" "0" "1.129" "1.022" "1.105" "1.054" "0.997" "1.123" "1.067" "1.034" "0.906" "470.6" "531.3" "480.8" "519.9" "496.2" "469.1" "528.7" "502.3" "486.6" "426.2" "" "" "" "" "" "" "" "" "" "" "417.3" "440.1" "419.5" "388.8" "413.8" "430.9" "446.8" "415.2" "446.3" "426.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "29.592" "37" "6" "19" "6" "147" "15.9" "8.21" "64.41" "6" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "0.966" "0.970" "0.933" "0.911" "0.941" "0.919" "0.951" "0.894" "0.579" "2293.2" "2214.4" "2224.5" "2140.5" "2089.4" "2157.0" "2107.3" "2180.4" "2049.2" "1328.7" "" "" "" "" "" "" "" "" "" "" "2033.5" "1834.3" "1940.9" "1600.8" "1742.3" "1981.5" "1781.0" "1802.3" "1879.4" "1328.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521587421576138717" "False" "High" "IsMasterProtein" "Q12800" "Alpha-globin transcription factor CP2 OS=Homo sapiens OX=9606 GN=TFCP2 PE=1 SV=2" "0.000" "False" "29.570" "8" "3" "7" "2" "502" "57.2" "5.80" "29.11" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7024" "ENSG00000135457" "TFCP2" "A8K5E9; hsa:7024; Q12800; Q12801; Q9UD75; Q9UD77" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.155" "0.926" "1.251" "1.018" "0.992" "1.004" "0.604" "1.063" "8.749" "138.1" "159.5" "127.9" "172.7" "140.6" "137.0" "138.7" "83.4" "146.8" "1208.1" "" "" "" "" "" "" "" "" "" "" "122.5" "132.1" "111.6" "129.2" "117.3" "125.8" "117.2" "68.9" "134.7" "1208.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "High" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.000" "False" "29.540" "6" "6" "8" "6" "1298" "146.5" "7.01" "31.32" "6" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "4" "0" "0.996" "0.991" "0.971" "1.077" "0.863" "1.025" "0.953" "0.912" "1.447" "430.4" "428.8" "426.5" "417.8" "463.7" "371.6" "441.0" "410.1" "392.8" "622.8" "" "" "" "" "" "" "" "" "" "" "381.7" "355.2" "372.1" "312.4" "386.6" "341.4" "372.8" "339.0" "360.2" "622.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6053253579863259654" "False" "High" "IsMasterProtein" "Q9P2M7" "Cingulin OS=Homo sapiens OX=9606 GN=CGN PE=1 SV=3" "0.000" "False" "29.522" "6" "9" "9" "8" "1203" "137.0" "5.52" "28.75" "9" "cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01576" "57530" "ENSG00000143375" "CGN" "A6H8L3; A7MD22; hsa:57530; Q5T386; Q9NR25; Q9P2M7" "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "15q11q13 copy number variation" "2" "0" "1.012" "0.941" "1.012" "1.029" "1.242" "1.124" "1.108" "1.186" "0.944" "550.4" "556.8" "518.1" "557.0" "566.1" "683.5" "618.8" "609.6" "652.8" "519.6" "" "" "" "" "" "" "" "" "" "" "488.1" "461.3" "452.1" "416.5" "472.0" "627.9" "523.0" "503.9" "598.7" "519.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1379432049065423837" "False" "High" "IsMasterProtein" "O75143" "Autophagy-related protein 13 OS=Homo sapiens OX=9606 GN=ATG13 PE=1 SV=1" "0.000" "False" "29.517" "18" "7" "7" "7" "517" "56.5" "5.12" "27.17" "7" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf10033" "9776" "ENSG00000175224" "ATG13" "B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8; hsa:9776; O75143; Q53EN6; Q9BRL3; Q9H8B0" "Macroautophagy" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "12" "0" "1.076" "1.005" "1.118" "1.117" "0.994" "1.044" "0.922" "0.928" "0.903" "590.8" "635.4" "593.9" "660.6" "659.8" "587.0" "616.6" "544.5" "548.4" "533.7" "" "" "" "" "" "" "" "" "" "" "523.9" "526.3" "518.2" "494.0" "550.2" "539.2" "521.1" "450.1" "503.0" "533.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "29.504" "28" "9" "16" "7" "207" "22.0" "9.38" "46.09" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "2" "0" "0.966" "1.014" "0.963" "0.959" "1.015" "0.994" "1.042" "1.023" "0.531" "1414.0" "1365.7" "1433.7" "1361.2" "1356.4" "1435.5" "1405.1" "1473.5" "1446.9" "751.0" "" "" "" "" "" "" "" "" "" "" "1253.9" "1131.3" "1250.9" "1018.0" "1131.1" "1318.7" "1187.5" "1218.0" "1327.0" "751.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751466246164002184" "False" "High" "IsMasterProtein" "O60613" "Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4" "0.000" "False" "29.487" "15" "2" "5" "2" "165" "18.1" "5.03" "19.72" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf08806" "9403" "ENSG00000183291" "SELENOF" "A0A0B4J1S4; hsa:9403; O60613; Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01" "" "Selenium metabolism / selenoproteins; Selenium micronutrient network" "2" "0" "1.018" "0.995" "1.008" "1.010" "1.038" "1.090" "1.091" "1.063" "0.778" "1032.7" "1051.3" "1027.1" "1040.8" "1043.1" "1071.9" "1125.9" "1126.5" "1097.9" "803.6" "" "" "" "" "" "" "" "" "" "" "915.8" "870.8" "896.2" "778.4" "869.8" "984.7" "951.5" "931.2" "1006.9" "803.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "29.480" "11" "6" "8" "6" "627" "70.7" "8.56" "21.80" "6" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "1.407" "1.156" "0.917" "0.862" "0.707" "0.779" "0.861" "1.240" "1.942" "309.3" "435.1" "357.6" "283.6" "266.5" "218.7" "240.9" "266.3" "383.5" "600.6" "" "" "" "" "" "" "" "" "" "" "274.3" "360.4" "312.0" "212.1" "222.2" "200.9" "203.6" "220.1" "351.7" "600.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1893119365438926918" "False" "High" "IsMasterProtein" "Q86UU0" "B-cell CLL/lymphoma 9-like protein OS=Homo sapiens OX=9606 GN=BCL9L PE=1 SV=1" "0.000" "False" "29.393" "5" "7" "7" "7" "1499" "157.0" "8.63" "25.89" "7" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf11502" "283149" "ENSG00000186174" "BCL9L" "A1A4C1; hsa:283149; Q67FY1; Q6ZWJ0; Q6ZWK2; Q86UU0" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "" "2" "0" "0.943" "0.870" "0.885" "0.873" "0.857" "0.829" "0.857" "0.853" "0.537" "1550.7" "1462.0" "1349.4" "1371.7" "1353.4" "1329.4" "1285.0" "1329.4" "1322.7" "833.2" "" "" "" "" "" "" "" "" "" "" "1375.1" "1211.0" "1177.4" "1025.8" "1128.5" "1221.2" "1086.1" "1098.8" "1213.1" "833.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3948795116760064813" "False" "High" "IsMasterProtein" "Q7Z2Z2" "Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2" "0.000" "False" "29.390" "6" "5" "6" "5" "1120" "125.4" "5.91" "24.98" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf14492" "79631" "ENSG00000140598" "EFL1" "A6NKY5; B7Z6I0; hsa:79631; Q7Z2Z2; Q9H8Z6" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "1.166" "0.905" "1.202" "1.128" "1.021" "1.223" "0.862" "0.923" "3.887" "94.7" "110.5" "85.7" "113.8" "106.8" "96.7" "115.9" "81.6" "87.4" "368.2" "" "" "" "" "" "" "" "" "" "" "84.0" "91.5" "74.8" "85.1" "89.1" "88.8" "97.9" "67.5" "80.2" "368.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7781995361222793159" "False" "High" "IsMasterProtein" "Q9UJX2" "Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3" "0.000" "False" "29.376" "13" "7" "7" "7" "597" "68.8" "7.02" "22.48" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04049" "8697" "ENSG00000094880" "CDC23" "A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.271" "1.282" "1.216" "1.342" "1.033" "1.126" "1.182" "1.497" "1.789" "280.5" "356.6" "359.6" "341.0" "376.4" "289.7" "315.8" "331.6" "420.0" "501.8" "" "" "" "" "" "" "" "" "" "" "248.8" "295.4" "313.8" "255.0" "313.9" "266.1" "266.9" "274.1" "385.2" "501.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622169396848351928" "False" "High" "IsMasterProtein" "Q8NFF5" "FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1" "0.000" "False" "29.336" "14" "8" "10" "8" "587" "65.2" "6.93" "31.89" "8" "other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00994, Pf01507" "80308" "ENSG00000160688" "FLAD1" "hsa:80308; Q8N5J1; Q8N686; Q8NFF5; Q8WU93; Q8WUJ4; Q96CR8; Q99764; Q9HBN6" "Vitamin B2 (riboflavin) metabolism" "Selenium micronutrient network; Folate metabolism" "3" "0" "0.964" "0.951" "1.046" "1.003" "1.011" "1.070" "1.045" "0.950" "1.469" "619.7" "597.2" "589.2" "647.9" "621.7" "626.7" "662.8" "647.8" "588.9" "910.6" "" "" "" "" "" "" "" "" "" "" "549.5" "494.7" "514.1" "484.5" "518.4" "575.7" "560.1" "535.5" "540.1" "910.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580326738670543746" "False" "High" "IsMasterProtein" "O60341" "Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2" "0.000" "False" "29.332" "10" "8" "8" "8" "852" "92.8" "6.52" "28.78" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01593, Pf04433" "23028" "ENSG00000004487" "KDM1A" "A8MWP9; hsa:23028; O60341; Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4" "Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "Androgen receptor signaling pathway; Effect of progerin on genes involved in progeria; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Neurogenesis regulation in the olfactory epithelium" "14" "0" "1.048" "1.058" "1.002" "1.066" "0.838" "0.914" "0.734" "0.917" "3.419" "450.7" "472.4" "476.7" "451.5" "480.7" "377.9" "411.8" "330.7" "413.2" "1541.2" "" "" "" "" "" "" "" "" "" "" "399.7" "391.3" "415.9" "337.7" "400.8" "347.1" "348.0" "273.4" "379.0" "1541.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9117117300834082613" "False" "High" "IsMasterProtein" "Q9H5N1" "Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2" "0.000" "False" "29.296" "12" "7" "8" "7" "569" "63.5" "4.78" "27.63" "7" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf03528, Pf09311" "79874" "ENSG00000177548" "RABEP2" "hsa:79874; Q9H5N1" "" "Ciliary landscape; 16p11.2 distal deletion syndrome" "2" "0" "0.920" "0.880" "0.873" "0.825" "0.740" "0.791" "0.752" "0.782" "2.507" "443.9" "408.5" "390.6" "387.7" "366.4" "328.4" "351.0" "333.7" "347.0" "1112.8" "" "" "" "" "" "" "" "" "" "" "393.7" "338.4" "340.8" "289.9" "305.5" "301.7" "296.7" "275.8" "318.3" "1112.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120276004969488072" "False" "High" "IsMasterProtein" "Q15080" "Neutrophil cytosol factor 4 OS=Homo sapiens OX=9606 GN=NCF4 PE=1 SV=2" "0.000" "False" "29.279" "24" "7" "7" "7" "339" "39.0" "6.83" "24.71" "7" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf00787" "4689" "ENSG00000100365" "NCF4" "A8K4F9; hsa:4689; O60808; Q15080; Q86U56; Q9BU98; Q9NP45" "VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; Detoxification of Reactive Oxygen Species; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "11" "0" "1.088" "0.947" "1.186" "1.120" "1.018" "1.074" "0.517" "0.972" "14.097" "151.5" "164.8" "143.5" "179.7" "169.7" "154.2" "162.7" "78.3" "147.2" "2135.2" "" "" "" "" "" "" "" "" "" "" "134.3" "136.5" "125.2" "134.4" "141.5" "141.6" "137.5" "64.8" "135.0" "2135.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "798152879982526566" "False" "High" "IsMasterProtein" "Q8WWH5" "Pseudouridylate synthase TRUB1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1" "0.000" "False" "29.273" "12" "4" "6" "4" "349" "37.2" "8.25" "24.26" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01509" "142940" "ENSG00000165832" "TRUB1" "B2R716; hsa:142940; Q53ES2; Q8WWH5" "" "" "0" "0" "1.050" "1.106" "1.096" "1.014" "1.157" "1.030" "0.930" "0.960" "1.750" "500.8" "526.0" "553.9" "548.7" "507.6" "579.2" "515.8" "465.9" "480.6" "876.5" "" "" "" "" "" "" "" "" "" "" "444.1" "435.7" "483.3" "410.3" "423.3" "532.0" "435.9" "385.1" "440.8" "876.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6108723454848240584" "False" "High" "IsMasterProtein" "Q7L7X3" "Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1" "0.000" "False" "29.241" "9" "8" "9" "6" "1001" "116.0" "7.65" "25.35" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "57551" "ENSG00000160551" "TAOK1" "A2RUT8; B7ZLV6; hsa:57551; Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; MAPK signaling pathway" "8" "0" "1.132" "0.915" "1.095" "0.984" "0.871" "1.033" "0.900" "0.949" "0.928" "680.7" "770.3" "622.9" "745.5" "669.7" "592.7" "703.0" "612.7" "645.7" "632.0" "" "" "" "" "" "" "" "" "" "" "603.6" "638.1" "543.5" "557.5" "558.4" "544.5" "594.1" "506.4" "592.2" "632.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.000" "False" "29.167" "18" "8" "8" "8" "472" "53.8" "5.80" "26.47" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "mRNA Splicing - Major Pathway" "" "1" "0" "1.013" "1.008" "0.885" "0.903" "1.048" "0.936" "0.869" "0.966" "2.265" "901.8" "913.2" "909.2" "798.4" "814.4" "945.4" "844.2" "784.1" "871.3" "2042.3" "" "" "" "" "" "" "" "" "" "" "799.7" "756.5" "793.3" "597.1" "679.1" "868.5" "713.5" "648.1" "799.1" "2042.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "29.155" "12" "4" "5" "4" "424" "44.4" "8.56" "20.85" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; 10q22q23 copy number variation" "4" "0" "0.932" "1.007" "0.844" "0.931" "0.906" "0.813" "0.973" "0.965" "0.652" "1070.6" "997.9" "1078.4" "904.1" "996.9" "969.9" "870.0" "1041.4" "1033.4" "698.3" "" "" "" "" "" "" "" "" "" "" "949.4" "826.6" "940.9" "676.1" "831.3" "891.0" "735.3" "860.8" "947.8" "698.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224070834007844842" "False" "High" "IsMasterProtein" "Q9BW91" "ADP-ribose pyrophosphatase, mitochondrial OS=Homo sapiens OX=9606 GN=NUDT9 PE=1 SV=1" "0.000" "False" "29.113" "24" "7" "8" "7" "350" "39.1" "8.22" "26.32" "7" "other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293" "53343" "ENSG00000170502" "NUDT9" "hsa:53343; Q8NBN1; Q8NCB9; Q8NG25; Q9BW91" "" "" "0" "0" "0.900" "0.881" "0.802" "0.833" "0.871" "0.773" "0.825" "0.903" "1.436" "554.2" "498.8" "488.2" "444.7" "461.9" "482.8" "428.1" "457.1" "500.1" "795.6" "" "" "" "" "" "" "" "" "" "" "491.4" "413.2" "426.0" "332.5" "385.2" "443.5" "361.8" "377.8" "458.7" "795.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.000" "False" "29.051" "36" "6" "7" "6" "179" "21.5" "5.68" "26.32" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "1.055" "1.053" "0.865" "0.894" "0.744" "0.730" "0.664" "0.773" "2.010" "1011.5" "1067.1" "1065.4" "874.6" "904.8" "752.4" "738.8" "671.9" "781.4" "2033.1" "" "" "" "" "" "" "" "" "" "" "897.0" "883.9" "929.7" "654.1" "754.5" "691.2" "624.4" "555.4" "716.7" "2033.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "29.031" "45" "4" "12" "4" "83" "9.3" "5.12" "41.52" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "Mitochondrial protein import" "" "1" "0" "0.940" "0.957" "0.955" "0.877" "0.991" "0.935" "0.917" "0.886" "0.347" "1184.7" "1114.2" "1134.2" "1131.2" "1038.8" "1174.6" "1107.3" "1086.6" "1049.7" "410.9" "" "" "" "" "" "" "" "" "" "" "1050.6" "922.9" "989.6" "846.0" "866.2" "1079.0" "935.9" "898.2" "962.8" "410.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "High" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.000" "False" "29.019" "37" "6" "20" "6" "157" "17.2" "8.91" "68.03" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "0.960" "1.184" "1.019" "0.960" "0.907" "0.868" "1.090" "1.228" "0.626" "2432.8" "2335.5" "2881.1" "2479.5" "2334.8" "2207.4" "2111.0" "2651.7" "2986.7" "1523.0" "" "" "" "" "" "" "" "" "" "" "2157.4" "1934.6" "2513.9" "1854.4" "1946.9" "2027.7" "1784.2" "2191.9" "2739.2" "1523.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5575516958920561508" "False" "High" "IsMasterProtein" "Q9H1Y0" "Autophagy protein 5 OS=Homo sapiens OX=9606 GN=ATG5 PE=1 SV=2" "0.000" "False" "29.013" "18" "5" "8" "5" "275" "32.4" "5.77" "30.57" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04106, Pf20637, Pf20638" "9474" "ENSG00000057663" "ATG5" "hsa:9474; O60875; Q5JVR2; Q68DI4; Q9H1Y0; Q9H2B8; Q9HCZ7" "Macroautophagy; Negative regulators of DDX58/IFIH1 signaling; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "13" "0" "1.029" "1.033" "1.013" "1.028" "1.028" "1.008" "1.008" "1.011" "0.722" "1228.7" "1264.4" "1269.0" "1244.3" "1263.4" "1263.4" "1238.4" "1238.9" "1241.6" "886.9" "" "" "" "" "" "" "" "" "" "" "1089.6" "1047.3" "1107.2" "930.5" "1053.5" "1160.6" "1046.6" "1024.1" "1138.8" "886.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939925399894006679" "False" "High" "IsMasterProtein" "Q9NWU2" "Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1" "0.000" "False" "29.005" "26" "5" "9" "5" "228" "26.7" "4.97" "33.38" "5" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08513, Pf10607" "54994" "ENSG00000101193" "GID8" "E1P5I3; hsa:54994; Q8N5M5; Q9NWU2" "" "Ciliary landscape" "1" "0" "1.000" "0.956" "1.036" "0.925" "1.024" "0.975" "0.880" "0.907" "1.368" "620.0" "619.9" "593.0" "642.6" "573.4" "635.0" "604.2" "545.5" "562.6" "848.1" "" "" "" "" "" "" "" "" "" "" "549.8" "513.5" "517.4" "480.5" "478.1" "583.3" "510.7" "450.9" "516.0" "848.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "High" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.000" "False" "28.984" "7" "5" "5" "5" "903" "97.3" "4.94" "20.29" "5" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "G protein signaling pathways" "3" "0" "0.969" "0.975" "0.995" "0.948" "1.024" "1.044" "0.990" "1.075" "0.943" "362.2" "351.1" "353.3" "360.4" "343.5" "370.8" "378.2" "358.5" "389.4" "341.6" "" "" "" "" "" "" "" "" "" "" "321.2" "290.8" "308.2" "269.5" "286.4" "340.6" "319.6" "296.3" "357.1" "341.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6240337966017765757" "False" "High" "IsMasterProtein" "Q0VDG4" "Secernin-3 OS=Homo sapiens OX=9606 GN=SCRN3 PE=1 SV=1" "0.000" "False" "28.857" "17" "6" "7" "6" "424" "48.5" "5.55" "26.71" "6" "protein metabolism" "" "other molecular function" "Pf03577" "79634" "ENSG00000144306" "SCRN3" "B4DI11; C9JPC1; D3DPE0; hsa:79634; Q0VDG4; Q7L1C5; Q9H5R5" "" "" "0" "0" "0.923" "0.907" "0.940" "0.881" "0.839" "0.909" "0.972" "0.877" "0.731" "306.3" "282.9" "277.7" "287.9" "269.7" "256.9" "278.4" "297.7" "268.7" "224.1" "" "" "" "" "" "" "" "" "" "" "271.6" "234.3" "242.3" "215.3" "224.9" "236.0" "235.3" "246.1" "246.4" "224.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "28.823" "9" "5" "6" "5" "710" "80.6" "5.86" "24.89" "5" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "1.113" "0.951" "1.073" "1.028" "1.013" "1.146" "0.919" "0.918" "2.263" "234.2" "260.6" "222.7" "251.2" "240.7" "237.2" "268.4" "215.2" "215.0" "530.0" "" "" "" "" "" "" "" "" "" "" "207.7" "215.9" "194.3" "187.9" "200.7" "217.9" "226.9" "177.9" "197.2" "530.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.000" "False" "28.823" "32" "6" "8" "6" "186" "21.1" "8.32" "28.76" "6" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "" "Pyrimidine metabolism" "1" "0" "1.019" "0.945" "1.134" "1.090" "1.086" "1.059" "1.025" "0.926" "0.530" "921.5" "938.6" "870.9" "1044.9" "1004.8" "1001.0" "976.3" "944.1" "853.2" "488.3" "" "" "" "" "" "" "" "" "" "" "817.1" "777.5" "759.9" "781.5" "837.9" "919.5" "825.1" "780.3" "782.5" "488.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.000" "False" "28.796" "16" "5" "7" "5" "463" "50.3" "8.15" "29.11" "5" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "Cerebral organic acidurias, including diseases" "2" "0" "1.022" "0.971" "1.052" "0.997" "0.975" "1.100" "1.086" "0.967" "0.726" "312.3" "319.0" "303.1" "328.4" "311.5" "304.4" "343.5" "339.2" "302.1" "226.6" "" "" "" "" "" "" "" "" "" "" "276.9" "264.3" "264.5" "245.6" "259.7" "279.6" "290.3" "280.4" "277.1" "226.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "28.790" "24" "7" "10" "7" "312" "34.3" "8.43" "34.57" "7" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Ciliary landscape" "3" "0" "1.143" "0.987" "1.231" "1.092" "0.930" "1.090" "0.613" "1.192" "11.149" "418.1" "477.9" "412.6" "514.8" "456.4" "388.7" "455.7" "256.4" "498.3" "4660.8" "" "" "" "" "" "" "" "" "" "" "370.7" "395.9" "360.0" "385.0" "380.6" "357.1" "385.1" "211.9" "457.0" "4660.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973916192928746401" "False" "High" "IsMasterProtein" "Q8N6N7" "Acyl-CoA-binding domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ACBD7 PE=1 SV=1" "0.000" "False" "28.781" "42" "4" "6" "4" "88" "9.8" "6.71" "23.72" "4" "other metabolic processes" "" "other molecular function" "Pf00887" "414149" "ENSG00000176244" "ACBD7" "A6NCI2; B3KTG8; hsa:414149; Q8N6N7" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "0.909" "0.999" "0.890" "0.860" "0.977" "0.926" "0.954" "0.881" "0.639" "758.4" "689.2" "757.4" "675.3" "652.4" "740.8" "702.6" "723.6" "668.5" "484.9" "" "" "" "" "" "" "" "" "" "" "672.5" "570.9" "660.8" "505.0" "544.0" "680.5" "593.8" "598.1" "613.1" "484.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.000" "False" "28.762" "7" "4" "8" "4" "785" "80.6" "7.34" "28.80" "4" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "42" "0" "0.964" "1.075" "0.918" "1.001" "0.935" "1.002" "1.000" "1.001" "1.085" "1082.1" "1043.6" "1162.9" "993.8" "1082.7" "1012.1" "1083.8" "1082.6" "1082.7" "1174.5" "" "" "" "" "" "" "" "" "" "" "959.6" "864.4" "1014.7" "743.3" "902.8" "929.8" "916.0" "894.8" "993.0" "1174.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387736998001173674" "False" "High" "IsMasterProtein" "Q969T4" "Ubiquitin-conjugating enzyme E2 E3 OS=Homo sapiens OX=9606 GN=UBE2E3 PE=1 SV=1" "0.000" "False" "28.751" "24" "4" "6" "2" "207" "22.9" "7.18" "24.23" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "10477" "ENSG00000170035" "UBE2E3" "B2RAD6; D3DPG3; hsa:10477; Q5U0R7; Q7Z4W4; Q969T4" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "7q11.23 copy number variation syndrome" "3" "0" "1.028" "0.935" "0.887" "0.867" "0.978" "0.917" "0.875" "0.752" "1.806" "156.3" "160.7" "146.2" "138.6" "135.6" "152.9" "143.4" "136.8" "117.5" "282.3" "" "" "" "" "" "" "" "" "" "" "138.6" "133.1" "127.5" "103.7" "113.1" "140.4" "121.2" "113.1" "107.7" "282.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.000" "False" "28.744" "28" "6" "20" "5" "164" "19.3" "11.65" "75.22" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "6" "0" "0.987" "1.009" "0.971" "0.979" "1.029" "1.134" "1.114" "1.234" "0.572" "2073.8" "2045.9" "2091.5" "2014.2" "2029.9" "2134.2" "2351.4" "2310.7" "2558.3" "1185.5" "" "" "" "" "" "" "" "" "" "" "1839.0" "1694.7" "1824.9" "1506.3" "1692.7" "1960.5" "1987.3" "1909.9" "2346.3" "1185.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-273580326344755001" "False" "High" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "0.000" "False" "28.739" "32" "5" "11" "5" "142" "15.6" "9.13" "38.65" "5" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "" "Complement system" "1" "0" "0.950" "1.020" "0.962" "0.957" "1.028" "0.960" "1.007" "1.007" "0.720" "858.6" "815.9" "876.1" "825.6" "821.3" "883.0" "824.7" "865.1" "864.5" "617.9" "" "" "" "" "" "" "" "" "" "" "761.4" "675.8" "764.4" "617.5" "684.9" "811.1" "697.0" "715.0" "792.9" "617.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "High" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.000" "False" "28.704" "50" "6" "7" "6" "147" "16.8" "5.35" "28.09" "6" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "Detoxification of Reactive Oxygen Species" "" "1" "0" "0.938" "0.973" "0.976" "1.033" "1.080" "0.952" "1.065" "0.949" "1.418" "330.2" "309.6" "321.3" "322.3" "341.2" "356.6" "314.5" "351.8" "313.4" "468.1" "" "" "" "" "" "" "" "" "" "" "292.8" "256.5" "280.3" "241.1" "284.5" "327.6" "265.8" "290.8" "287.4" "468.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "High" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.000" "False" "28.659" "13" "8" "9" "8" "589" "65.4" "6.80" "30.59" "8" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "1.077" "1.023" "1.076" "1.089" "1.081" "1.059" "1.080" "1.012" "0.576" "1034.6" "1114.7" "1058.9" "1112.8" "1126.7" "1118.8" "1095.3" "1117.6" "1047.0" "596.1" "" "" "" "" "" "" "" "" "" "" "917.5" "923.4" "923.9" "832.2" "939.5" "1027.7" "925.7" "923.8" "960.2" "596.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8637323044109722120" "False" "High" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "0.000" "False" "28.648" "6" "6" "7" "6" "1250" "141.0" "5.31" "21.11" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.026" "0.991" "1.033" "0.955" "0.980" "1.040" "0.929" "0.984" "2.047" "667.4" "684.8" "661.7" "689.6" "637.4" "653.9" "693.9" "619.9" "656.5" "1366.4" "" "" "" "" "" "" "" "" "" "" "591.8" "567.3" "577.4" "515.7" "531.5" "600.7" "586.5" "512.4" "602.1" "1366.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "28.636" "15" "7" "7" "4" "483" "51.7" "8.00" "30.56" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "0" "1.062" "0.993" "1.044" "1.014" "0.941" "1.198" "1.104" "1.029" "1.540" "617.4" "655.5" "613.0" "644.7" "625.9" "580.9" "739.9" "681.9" "635.0" "950.5" "" "" "" "" "" "" "" "" "" "" "547.5" "543.0" "534.9" "482.2" "521.9" "533.6" "625.3" "563.6" "582.4" "950.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.000" "False" "28.571" "7" "6" "7" "6" "904" "98.6" "8.40" "24.26" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "0.909" "0.856" "0.799" "0.808" "0.799" "0.867" "0.738" "0.896" "2.797" "285.4" "259.5" "244.3" "228.2" "230.7" "228.0" "247.4" "210.7" "255.6" "798.5" "" "" "" "" "" "" "" "" "" "" "253.1" "215.0" "213.2" "170.6" "192.4" "209.5" "209.1" "174.2" "234.4" "798.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1282007746480283530" "False" "High" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "0.000" "False" "28.570" "22" "5" "9" "4" "211" "23.3" "8.91" "33.14" "5" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "Q8NAI2; Q9BRJ7" "" "" "0" "0" "1.020" "1.047" "1.062" "1.082" "1.052" "1.097" "1.141" "1.080" "0.749" "604.1" "616.4" "632.7" "641.4" "653.6" "635.3" "662.5" "689.0" "652.5" "452.4" "" "" "" "" "" "" "" "" "" "" "535.7" "510.6" "552.1" "479.7" "545.0" "583.6" "559.9" "569.5" "598.4" "452.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8275820454411589683" "False" "High" "IsMasterProtein" "Cont_P41361" "Antithrombin-III OS=Bos taurus OX=9913 GN=SERPINC1 PE=1 SV=2" "0.000" "True" "28.531" "14" "6" "7" "6" "465" "52.3" "7.33" "22.88" "6" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00079" "540261" "" "SERPINC1" "bta:540261; P41361; Q3SZQ7" "" "" "0" "0" "1.010" "0.991" "1.007" "0.995" "1.043" "0.952" "1.014" "1.015" "0.676" "332.9" "336.3" "329.9" "335.4" "331.3" "347.1" "317.1" "337.6" "337.8" "225.2" "" "" "" "" "" "" "" "" "" "" "295.2" "278.6" "287.9" "250.8" "276.2" "318.9" "268.0" "279.0" "309.8" "225.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8154313858001218704" "False" "High" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "0.000" "False" "28.497" "3" "7" "7" "4" "2542" "269.3" "5.73" "22.95" "7" "stress response" "other cell component" "" "Pf00013, Pf12796, Pf13637" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "1" "0.988" "0.859" "1.068" "0.914" "0.917" "0.937" "0.699" "0.857" "7.643" "164.3" "162.4" "141.2" "175.5" "150.2" "150.7" "153.9" "114.8" "140.8" "1255.9" "" "" "" "" "" "" "" "" "" "" "145.7" "134.5" "123.2" "131.3" "125.3" "138.4" "130.1" "94.9" "129.2" "1255.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728784246141405942" "False" "High" "IsMasterProtein" "P09543" "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" "0.000" "False" "28.464" "19" "9" "13" "8" "421" "47.5" "9.07" "37.20" "9" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf05881, Pf13671" "1267" "ENSG00000173786" "CNP" "hsa:1267; P09543" "" "Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Cell lineage map for neuronal differentiation" "5" "0" "1.053" "0.881" "1.128" "1.084" "0.991" "1.115" "1.195" "1.044" "1.419" "451.1" "475.1" "397.4" "509.0" "489.2" "447.3" "502.8" "539.3" "471.2" "640.0" "" "" "" "" "" "" "" "" "" "" "400.1" "393.5" "346.7" "380.6" "408.0" "410.9" "425.0" "445.7" "432.1" "640.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.000" "False" "28.463" "9" "4" "6" "4" "563" "61.2" "6.48" "24.59" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "XBP1(S) activates chaperone genes" "VEGFA-VEGFR2 signaling" "2" "0" "1.167" "1.201" "1.196" "1.141" "1.248" "1.215" "1.260" "1.089" "1.294" "187.2" "218.5" "224.9" "223.9" "213.6" "233.7" "227.6" "235.9" "203.9" "242.3" "" "" "" "" "" "" "" "" "" "" "166.0" "181.0" "196.2" "167.5" "178.1" "214.7" "192.3" "194.9" "187.0" "242.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428917072824426789" "False" "High" "IsMasterProtein" "Q8NDV7" "Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2" "0.000" "False" "28.412" "2" "3" "4" "3" "1962" "210.2" "7.01" "15.80" "3" "stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf10427, Pf16608" "27327" "ENSG00000090905" "TNRC6A" "C9JAR8; hsa:27327; O15408; Q658L5; Q6NVB5; Q8NDV7; Q8NEZ0; Q8TBT8; Q8TCR0; Q9NV59; Q9P268" "MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Transcriptional regulation by small RNAs; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "" "19" "0" "0.948" "0.820" "0.826" "0.798" "0.930" "0.791" "0.881" "0.839" "0.678" "331.1" "313.7" "271.4" "273.5" "264.1" "307.9" "261.9" "291.8" "277.8" "224.6" "" "" "" "" "" "" "" "" "" "" "293.6" "259.9" "236.8" "204.6" "220.2" "282.8" "221.4" "241.2" "254.8" "224.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5010086175827698668" "False" "High" "IsMasterProtein" "P42575" "Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2" "0.000" "False" "28.399" "17" "6" "6" "6" "452" "50.7" "6.81" "22.82" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00619, Pf00656" "835" "ENSG00000106144" "CASP2" "A8K5F9; D3DXD6; E9PDN0; hsa:835; P42575; P42576; Q59F21; Q7KZL6; Q86UJ3; Q9BUP7; Q9BZK9; Q9BZL0" "TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling" "Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis" "8" "0" "0.881" "0.731" "0.840" "0.722" "0.644" "0.685" "0.705" "0.760" "1.869" "464.3" "409.0" "339.2" "390.2" "335.0" "299.1" "317.9" "327.2" "352.6" "867.8" "" "" "" "" "" "" "" "" "" "" "411.7" "338.8" "296.0" "291.8" "279.4" "274.7" "268.7" "270.4" "323.4" "867.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "High" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.000" "False" "28.388" "17" "7" "10" "7" "374" "43.2" "6.21" "25.63" "7" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "9" "0" "1.053" "0.948" "1.125" "1.010" "0.968" "1.127" "1.147" "0.952" "0.495" "690.3" "726.8" "654.7" "776.9" "697.1" "668.4" "777.8" "792.0" "656.8" "341.9" "" "" "" "" "" "" "" "" "" "" "612.1" "602.0" "571.2" "581.0" "581.3" "614.0" "657.3" "654.7" "602.4" "341.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "28.369" "8" "8" "10" "8" "1096" "123.4" "8.82" "32.97" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "4" "0" "1.006" "0.987" "1.104" "0.996" "0.974" "0.958" "0.948" "0.941" "0.783" "775.9" "780.3" "765.9" "856.9" "773.0" "755.6" "743.6" "735.7" "729.7" "607.3" "" "" "" "" "" "" "" "" "" "" "688.1" "646.3" "668.3" "640.8" "644.6" "694.1" "628.4" "608.1" "669.3" "607.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "28.358" "15" "7" "10" "7" "482" "55.8" "6.48" "30.85" "7" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.902" "1.103" "0.895" "0.907" "0.900" "0.963" "1.032" "1.515" "1.473" "538.9" "485.9" "594.3" "482.5" "488.5" "484.8" "518.9" "555.8" "816.2" "793.8" "" "" "" "" "" "" "" "" "" "" "477.9" "402.5" "518.5" "360.8" "407.4" "445.4" "438.5" "459.4" "748.6" "793.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "High" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.000" "False" "28.310" "20" "5" "7" "5" "301" "33.8" "8.00" "29.09" "5" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "Glycosphingolipid catabolism; The activation of arylsulfatases" "" "2" "0" "1.317" "0.953" "0.989" "0.994" "0.883" "1.114" "0.955" "1.029" "2.462" "289.8" "381.8" "276.2" "286.7" "288.2" "255.8" "322.9" "276.8" "298.2" "713.5" "" "" "" "" "" "" "" "" "" "" "257.0" "316.3" "241.0" "214.4" "240.3" "235.0" "272.9" "228.8" "273.5" "713.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.000" "False" "28.291" "10" "7" "7" "7" "718" "83.0" "5.92" "24.00" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "10" "0" "1.182" "0.984" "1.379" "1.043" "1.008" "1.083" "0.771" "0.985" "6.990" "140.8" "166.4" "138.5" "194.2" "146.8" "141.9" "152.5" "108.6" "138.8" "984.2" "" "" "" "" "" "" "" "" "" "" "124.9" "137.8" "120.9" "145.2" "122.4" "130.4" "128.9" "89.8" "127.3" "984.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1417683235143357946" "False" "High" "IsMasterProtein" "P20023" "Complement receptor type 2 OS=Homo sapiens OX=9606 GN=CR2 PE=1 SV=2" "0.000" "False" "28.256" "7" "8" "8" "8" "1033" "112.8" "7.52" "27.72" "8" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00084" "1380" "ENSG00000117322" "CR2" "C9JHD2; hsa:1380; P20023; Q13866; Q14212; Q53EL2; Q5BKT9; Q5SR46; Q5SR48" "Regulation of Complement cascade" "B cell receptor signaling pathway; Complement system; Dengue-2 interactions with complement and coagulation cascades; Oxidative damage response; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Extrafollicular and follicular B cell activation by SARS-CoV-2; Complement and coagulation cascades" "9" "0" "0.945" "1.006" "0.944" "0.895" "0.949" "0.863" "0.862" "0.958" "0.446" "1045.2" "988.1" "1051.3" "986.5" "935.9" "992.4" "902.5" "901.2" "1000.8" "466.1" "" "" "" "" "" "" "" "" "" "" "926.8" "818.5" "917.3" "737.8" "780.4" "911.6" "762.7" "744.9" "917.9" "466.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4937271554403891889" "False" "High" "IsMasterProtein" "P16150" "Leukosialin OS=Homo sapiens OX=9606 GN=SPN PE=1 SV=1" "0.000" "False" "28.240" "18" "5" "7" "5" "400" "40.3" "5.10" "28.68" "5" "cell adhesion;cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "" "6693" "ENSG00000197471" "SPN" "A8K9B1; hsa:6693; P16150" "Basigin interactions" "16p11.2 proximal deletion syndrome" "3" "0" "1.048" "0.920" "0.959" "0.899" "0.969" "0.904" "0.906" "0.985" "0.624" "1235.0" "1293.8" "1136.5" "1185.0" "1110.7" "1196.6" "1116.1" "1118.8" "1217.1" "770.9" "" "" "" "" "" "" "" "" "" "" "1095.2" "1071.8" "991.6" "886.2" "926.2" "1099.2" "943.3" "924.7" "1116.2" "770.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4792290450889044309" "False" "High" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "0.000" "False" "28.196" "11" "8" "10" "8" "654" "74.3" "6.89" "31.57" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "1" "0" "1.104" "1.130" "1.147" "1.157" "1.057" "1.127" "0.933" "1.108" "3.182" "175.7" "194.0" "198.5" "201.5" "203.3" "185.6" "197.9" "163.9" "194.6" "559.0" "" "" "" "" "" "" "" "" "" "" "155.8" "160.7" "173.2" "150.7" "169.5" "170.5" "167.3" "135.4" "178.5" "559.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "28.190" "29" "8" "17" "8" "196" "21.7" "8.06" "45.78" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "HCMV Late Events" "" "1" "0" "0.967" "0.899" "0.904" "0.914" "0.837" "0.796" "0.897" "0.950" "0.467" "1499.5" "1450.1" "1347.6" "1355.3" "1371.1" "1254.5" "1193.4" "1345.4" "1424.3" "700.4" "" "" "" "" "" "" "" "" "" "" "1329.7" "1201.2" "1175.8" "1013.6" "1143.3" "1152.4" "1008.6" "1112.0" "1306.3" "700.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "255349237203839233" "False" "High" "IsMasterProtein" "Q9Y2Y1" "DNA-directed RNA polymerase III subunit RPC10 OS=Homo sapiens OX=9606 GN=POLR3K PE=1 SV=3" "0.000" "False" "28.182" "54" "4" "4" "4" "108" "12.3" "7.83" "19.69" "4" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "51728" "ENSG00000161980" "POLR3K" "hsa:51728; Q1W6H4; Q96S35; Q9Y2Y1" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "1.087" "1.108" "1.024" "1.077" "1.118" "1.005" "1.031" "0.985" "0.781" "569.3" "618.6" "631.0" "582.8" "612.9" "636.7" "572.2" "587.2" "560.8" "444.6" "" "" "" "" "" "" "" "" "" "" "504.8" "512.4" "550.6" "435.9" "511.0" "584.9" "483.6" "485.4" "514.3" "444.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "28.166" "24" "5" "9" "5" "199" "23.6" "9.01" "32.93" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.040" "1.030" "0.920" "0.880" "1.195" "0.910" "1.124" "0.997" "0.496" "618.5" "643.4" "636.9" "569.2" "544.3" "739.1" "563.0" "694.9" "616.3" "306.9" "" "" "" "" "" "" "" "" "" "" "548.5" "533.0" "555.7" "425.7" "453.9" "679.0" "475.8" "574.4" "565.3" "306.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "High" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.000" "False" "28.155" "25" "6" "7" "5" "272" "31.2" "11.59" "25.33" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "6" "1" "0.991" "0.888" "1.113" "1.013" "0.920" "0.940" "0.994" "0.959" "0.845" "637.4" "631.4" "566.2" "709.4" "645.8" "586.3" "599.1" "633.8" "611.4" "538.4" "" "" "" "" "" "" "" "" "" "" "565.3" "523.0" "494.0" "530.5" "538.5" "538.6" "506.4" "523.9" "560.8" "538.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653073458972591476" "False" "High" "IsMasterProtein" "O75683" "Surfeit locus protein 6 OS=Homo sapiens OX=9606 GN=SURF6 PE=1 SV=3" "0.000" "False" "28.152" "17" "5" "5" "5" "361" "41.4" "10.64" "19.41" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04935" "6838" "ENSG00000148296; ENSG00000281309" "SURF6" "hsa:6838; O75683; Q5T8U1; Q9BRK9; Q9BTZ5; Q9UK24" "" "" "0" "0" "0.970" "0.972" "0.951" "0.987" "0.974" "0.732" "0.760" "0.720" "0.284" "326.6" "316.8" "317.6" "310.7" "322.3" "318.2" "239.1" "248.2" "235.0" "92.7" "" "" "" "" "" "" "" "" "" "" "289.7" "262.4" "277.1" "232.3" "268.8" "292.3" "202.1" "205.2" "215.6" "92.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "28.147" "10" "5" "5" "4" "621" "69.7" "6.15" "21.74" "5" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Signaling by BRAF and RAF1 fusions" "Bile acids synthesis and enterohepatic circulation" "2" "0" "0.922" "0.910" "0.957" "0.909" "1.045" "0.883" "0.835" "0.954" "2.108" "319.8" "294.8" "291.0" "306.0" "290.8" "334.1" "282.3" "267.0" "305.1" "674.2" "" "" "" "" "" "" "" "" "" "" "283.6" "244.2" "253.9" "228.8" "242.5" "306.9" "238.6" "220.7" "279.9" "674.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1529174177095472519" "False" "High" "IsMasterProtein" "O14777" "Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1" "0.000" "False" "28.130" "10" "7" "7" "7" "642" "73.9" "5.60" "24.52" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03801, Pf18077" "10403" "ENSG00000080986" "NDC80" "hsa:10403; O14777; Q6PJX2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.324" "0.941" "1.150" "1.165" "1.244" "1.082" "0.395" "1.190" "11.637" "183.8" "243.4" "172.9" "211.3" "214.0" "228.7" "198.9" "72.5" "218.6" "2138.6" "" "" "" "" "" "" "" "" "" "" "163.0" "201.6" "150.9" "158.0" "178.5" "210.1" "168.1" "60.0" "200.5" "2138.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "High" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.000" "False" "28.124" "21" "5" "7" "5" "283" "31.8" "9.92" "27.72" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "Sphingolipid metabolism in senescence" "3" "0" "1.008" "0.953" "0.991" "1.013" "1.001" "0.956" "0.872" "0.871" "0.698" "948.8" "956.2" "904.4" "940.7" "961.4" "950.1" "907.0" "827.4" "826.8" "662.5" "" "" "" "" "" "" "" "" "" "" "841.4" "792.1" "789.1" "703.5" "801.7" "872.7" "766.6" "683.9" "758.3" "662.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1884707447535219714" "False" "High" "IsMasterProtein" "Q9BYM8" "RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2" "0.000" "False" "28.107" "10" "4" "5" "4" "510" "57.5" "5.67" "20.33" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13445" "10616" "ENSG00000125826" "RBCK1" "O95623; Q86SL2; Q96BS3; Q9BYM8; Q9BYM9" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "TAR syndrome" "5" "0" "0.905" "1.017" "1.009" "0.908" "0.941" "0.868" "1.009" "1.065" "1.429" "101.1" "91.5" "102.8" "102.0" "91.8" "95.1" "87.7" "101.9" "107.7" "144.4" "" "" "" "" "" "" "" "" "" "" "89.6" "75.8" "89.7" "76.3" "76.5" "87.4" "74.1" "84.3" "98.7" "144.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657870357206849576" "False" "High" "IsMasterProtein" "Q9Y2Y0" "ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1" "0.000" "False" "28.105" "24" "3" "4" "3" "163" "18.8" "4.35" "17.33" "3" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11527" "23568" "ENSG00000102931" "ARL2BP" "B3KQJ5; hsa:23568; Q504R0; Q9Y2Y0" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" "Ciliopathies" "2" "0" "1.035" "0.937" "1.123" "0.978" "0.963" "1.131" "1.105" "1.045" "2.567" "284.7" "294.7" "266.6" "319.6" "278.3" "274.2" "321.9" "314.5" "297.4" "730.9" "" "" "" "" "" "" "" "" "" "" "252.4" "244.1" "232.6" "239.0" "232.0" "251.9" "272.0" "260.0" "272.7" "730.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7042305927855089094" "False" "High" "IsMasterProtein" "Q96E09" "PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 OS=Homo sapiens OX=9606 GN=PABIR1 PE=1 SV=1" "0.000" "False" "28.048" "24" "4" "4" "4" "287" "30.5" "6.79" "19.90" "4" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "" "116224" "ENSG00000187866" "PABIR1" "hsa:116224; Q96E09" "" "" "0" "0" "0.945" "1.006" "1.094" "1.042" "1.082" "1.101" "1.004" "1.002" "0.776" "217.3" "205.4" "218.6" "237.8" "226.4" "235.0" "239.2" "218.1" "217.7" "168.6" "" "" "" "" "" "" "" "" "" "" "192.7" "170.1" "190.8" "177.8" "188.8" "215.9" "202.2" "180.2" "199.6" "168.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769512896140685031" "False" "High" "IsMasterProtein" "Q16831" "Uridine phosphorylase 1 OS=Homo sapiens OX=9606 GN=UPP1 PE=1 SV=1" "0.000" "False" "28.040" "23" "7" "7" "7" "310" "33.9" "7.88" "26.53" "7" "other metabolic processes;stress response" "cytosol;nucleus" "other molecular function" "Pf01048" "7378" "ENSG00000183696" "UPP1" "D3DVM4; hsa:7378; Q15362; Q16831" "Pyrimidine salvage; Pyrimidine catabolism" "Fluoropyrimidine activity; Pyrimidine metabolism" "4" "0" "1.124" "1.050" "1.174" "1.103" "1.064" "1.106" "1.032" "0.866" "0.631" "429.5" "482.7" "450.8" "504.4" "473.6" "457.2" "475.3" "443.4" "372.0" "271.0" "" "" "" "" "" "" "" "" "" "" "380.9" "399.8" "393.3" "377.2" "394.9" "420.0" "401.7" "366.5" "341.2" "271.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4102844417532121967" "False" "High" "IsMasterProtein" "Q15560" "Transcription elongation factor A protein 2 OS=Homo sapiens OX=9606 GN=TCEA2 PE=1 SV=1" "0.000" "False" "28.022" "11" "3" "5" "1" "299" "33.6" "9.13" "21.95" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6919" "ENSG00000171703" "TCEA2" "B3KNM1; Q15560; Q8TD37; Q8TD38" "" "" "0" "0" "1.445" "1.187" "1.072" "1.065" "1.260" "1.273" "0.880" "1.142" "1.936" "44.3" "64.1" "52.6" "47.5" "47.2" "55.9" "56.4" "39.0" "50.6" "85.8" "" "" "" "" "" "" "" "" "" "" "39.3" "53.1" "45.9" "35.5" "39.4" "51.3" "47.7" "32.2" "46.4" "85.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3728877322360888626" "False" "High" "IsMasterProtein" "P62854" "Small ribosomal subunit protein eS26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3" "0.000" "False" "28.018" "31" "3" "4" "3" "115" "13.0" "11.00" "17.59" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01283" "6231" "ENSG00000197728" "RPS26" "hsa:6231; P02383; P62854; P70394; Q06722; Q3MHD8; Q6IRY4" "Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.103" "1.161" "1.063" "1.222" "1.107" "1.011" "1.079" "1.058" "1.503" "238.9" "263.5" "277.5" "254.1" "291.9" "264.4" "241.5" "257.8" "252.8" "359.2" "" "" "" "" "" "" "" "" "" "" "211.9" "218.3" "242.1" "190.0" "243.4" "242.9" "204.1" "213.1" "231.8" "359.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6395049123037932349" "False" "High" "IsMasterProtein" "P30793" "GTP cyclohydrolase 1 OS=Homo sapiens OX=9606 GN=GCH1 PE=1 SV=1" "0.000" "False" "27.926" "22" "7" "8" "7" "250" "27.9" "8.56" "28.29" "7" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01227" "2643" "ENSG00000131979" "GCH1" "hsa:2643; P30793; Q6FHY7; Q9Y4I8" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "Ferroptosis" "2" "0" "1.063" "1.015" "1.128" "1.079" "1.090" "1.156" "1.126" "1.026" "0.575" "764.6" "813.1" "775.7" "862.5" "825.2" "833.7" "883.6" "860.8" "784.4" "439.9" "" "" "" "" "" "" "" "" "" "" "678.0" "673.5" "676.9" "645.0" "688.1" "765.8" "746.8" "711.5" "719.4" "439.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "27.899" "33" "5" "10" "5" "119" "13.4" "9.94" "31.22" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.860" "0.837" "0.818" "0.773" "0.660" "0.658" "0.751" "0.753" "0.760" "1248.4" "1073.6" "1044.4" "1021.2" "965.1" "824.1" "820.9" "937.3" "940.2" "948.3" "" "" "" "" "" "" "" "" "" "" "1107.0" "889.3" "911.3" "763.7" "804.7" "757.1" "693.8" "774.7" "862.3" "948.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076182377996629975" "False" "High" "IsMasterProtein" "Q9H8U3" "AN1-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=ZFAND3 PE=1 SV=1" "0.000" "False" "27.842" "25" "5" "8" "5" "227" "25.2" "7.43" "30.84" "5" "" "" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "60685" "ENSG00000156639" "ZFAND3" "hsa:60685; Q5SZZ0; Q5SZZ1; Q9H8U3" "" "" "0" "0" "1.036" "0.994" "1.044" "1.106" "1.001" "0.900" "0.950" "0.923" "0.566" "980.1" "1015.1" "974.5" "1023.3" "1084.2" "980.6" "882.0" "930.6" "904.4" "554.6" "" "" "" "" "" "" "" "" "" "" "869.1" "840.9" "850.3" "765.3" "904.1" "900.8" "745.5" "769.2" "829.4" "554.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857445100061984594" "False" "High" "IsMasterProtein" "Q8WVY7" "Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2" "0.000" "False" "27.833" "21" "6" "7" "6" "318" "36.8" "6.46" "27.32" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00240, Pf03031" "134510" "ENSG00000164332" "UBLCP1" "D3DQJ7; hsa:134510; Q8WVY7; Q96DK5" "" "" "0" "0" "1.121" "1.107" "1.115" "1.033" "1.019" "0.953" "0.760" "0.872" "4.090" "885.0" "991.7" "979.6" "987.0" "913.9" "901.9" "843.4" "672.3" "772.0" "3619.9" "" "" "" "" "" "" "" "" "" "" "784.8" "821.5" "854.7" "738.2" "762.1" "828.5" "712.8" "555.7" "708.1" "3619.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "27.810" "27" "7" "14" "7" "229" "25.2" "4.64" "47.34" "7" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "11" "0" "0.965" "0.935" "1.050" "1.049" "1.072" "0.971" "1.081" "1.025" "0.379" "749.0" "722.5" "700.7" "786.2" "785.5" "803.2" "727.2" "809.9" "768.0" "284.0" "" "" "" "" "" "" "" "" "" "" "664.2" "598.5" "611.4" "588.0" "655.0" "737.8" "614.6" "669.5" "704.4" "284.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3767865638315377274" "False" "High" "IsMasterProtein" "O60684" "Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1" "0.000" "False" "27.802" "11" "6" "7" "2" "536" "60.0" "4.98" "29.14" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "23633" "ENSG00000025800" "KPNA6" "B2RDC7; D3DPP5; hsa:23633; O60684; Q5VVU3" "Assembly of the ORC complex at the origin of replication" "" "1" "0" "0.957" "0.733" "0.981" "0.825" "0.879" "1.082" "0.367" "0.812" "8.834" "74.9" "71.7" "54.9" "73.5" "61.9" "65.9" "81.1" "27.5" "60.9" "662.1" "" "" "" "" "" "" "" "" "" "" "66.5" "59.4" "47.9" "55.0" "51.6" "60.5" "68.5" "22.8" "55.8" "662.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "27.797" "36" "6" "11" "6" "176" "20.1" "6.39" "31.64" "6" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "1.057" "1.016" "1.045" "0.954" "1.025" "1.049" "0.996" "1.038" "0.712" "430.8" "455.3" "437.6" "450.2" "410.9" "441.6" "451.9" "429.0" "447.0" "306.9" "" "" "" "" "" "" "" "" "" "" "382.0" "377.2" "381.9" "336.7" "342.6" "405.6" "381.9" "354.6" "410.0" "306.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4539117867176903484" "False" "High" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "0.000" "False" "27.748" "24" "6" "8" "6" "254" "29.0" "5.50" "25.64" "6" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "12" "0" "0.960" "0.945" "0.943" "0.972" "1.061" "0.958" "1.015" "0.898" "0.511" "576.2" "553.0" "544.6" "543.5" "559.8" "611.3" "551.8" "584.7" "517.6" "294.6" "" "" "" "" "" "" "" "" "" "" "510.9" "458.1" "475.2" "406.5" "466.8" "561.6" "466.3" "483.3" "474.7" "294.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4494459322637692894" "False" "High" "IsMasterProtein" "Q5VSY0" "G kinase-anchoring protein 1 OS=Homo sapiens OX=9606 GN=GKAP1 PE=1 SV=2" "0.000" "False" "27.741" "20" "8" "9" "8" "366" "42.1" "8.82" "35.71" "8" "signal transduction;other biological processes" "ER/Golgi" "other molecular function" "" "80318" "ENSG00000165113" "GKAP1" "hsa:80318; Q5VSY0; Q96LI0; Q9BYI1; Q9BYI2; Q9H225" "" "" "0" "0" "0.938" "0.857" "0.862" "0.818" "0.791" "0.764" "0.837" "0.860" "0.461" "1177.1" "1104.7" "1008.4" "1015.0" "963.1" "931.1" "899.3" "984.8" "1012.4" "542.3" "" "" "" "" "" "" "" "" "" "" "1043.8" "915.1" "879.9" "759.1" "803.1" "855.4" "760.0" "814.0" "928.5" "542.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "High" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.000" "False" "27.734" "22" "5" "11" "4" "275" "29.7" "6.80" "35.73" "5" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "" "3" "0" "1.084" "1.097" "1.079" "1.070" "1.084" "0.955" "1.111" "1.093" "0.807" "328.6" "356.4" "360.4" "354.5" "351.5" "356.1" "313.7" "365.2" "359.2" "265.1" "" "" "" "" "" "" "" "" "" "" "291.4" "295.2" "314.4" "265.1" "293.1" "327.2" "265.1" "301.9" "329.4" "265.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "27.729" "15" "8" "9" "8" "490" "54.9" "10.13" "29.11" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "0.887" "0.824" "0.842" "0.828" "0.845" "0.593" "0.592" "0.597" "0.374" "1019.6" "904.3" "840.6" "858.8" "844.4" "861.6" "604.6" "603.7" "608.8" "381.1" "" "" "" "" "" "" "" "" "" "" "904.2" "749.1" "733.5" "642.2" "704.1" "791.5" "511.0" "499.0" "558.3" "381.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "High" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.000" "False" "27.727" "5" "5" "6" "5" "1148" "128.2" "9.36" "24.77" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "22" "0" "0.996" "0.927" "0.908" "0.931" "0.951" "0.903" "0.812" "0.966" "1.182" "408.6" "406.9" "378.7" "371.0" "380.2" "388.4" "368.9" "331.7" "394.5" "482.8" "" "" "" "" "" "" "" "" "" "" "362.3" "337.1" "330.5" "277.5" "317.1" "356.7" "311.8" "274.2" "361.8" "482.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2318951358478494228" "False" "High" "IsMasterProtein" "Q8WW01" "tRNA-splicing endonuclease subunit Sen15 OS=Homo sapiens OX=9606 GN=TSEN15 PE=1 SV=1" "0.000" "False" "27.717" "20" "2" "4" "2" "171" "18.6" "4.58" "17.52" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf09631" "116461" "ENSG00000198860" "TSEN15" "B4DKP0; hsa:116461; Q8WW01; Q9BZQ5" "tRNA processing in the nucleus" "" "1" "0" "1.112" "0.898" "1.140" "1.083" "1.068" "1.030" "1.047" "1.075" "0.753" "303.3" "337.2" "272.2" "345.7" "328.3" "323.9" "312.2" "317.6" "326.0" "228.5" "" "" "" "" "" "" "" "" "" "" "268.9" "279.3" "237.5" "258.5" "273.8" "297.5" "263.9" "262.5" "299.0" "228.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6662749909958562405" "False" "High" "IsMasterProtein" "Q99467" "CD180 antigen OS=Homo sapiens OX=9606 GN=CD180 PE=1 SV=2" "0.000" "False" "27.715" "5" "3" "4" "3" "661" "74.1" "6.43" "18.22" "3" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytoskeleton;nucleus" "" "Pf13855, Pf18831" "4064" "ENSG00000134061" "CD180" "B2R7Z7; hsa:4064; Q32MM5; Q99467" "Toll Like Receptor 4 (TLR4) Cascade" "" "1" "0" "1.151" "1.024" "1.035" "1.254" "1.341" "1.181" "1.151" "1.211" "0.824" "270.5" "311.2" "277.0" "280.0" "339.1" "362.6" "319.4" "311.3" "327.5" "222.8" "" "" "" "" "" "" "" "" "" "" "239.9" "257.8" "241.7" "209.4" "282.8" "333.1" "270.0" "257.3" "300.4" "222.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "27.668" "21" "3" "6" "3" "143" "15.8" "10.49" "20.03" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Protein hydroxylation; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "0.930" "0.970" "1.092" "0.972" "0.907" "0.918" "0.969" "0.951" "1.561" "674.2" "627.3" "653.7" "736.1" "655.2" "611.5" "618.8" "653.5" "641.0" "1052.1" "" "" "" "" "" "" "" "" "" "" "597.9" "519.6" "570.4" "550.5" "546.4" "561.7" "523.0" "540.2" "587.8" "1052.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758038755542979545" "False" "High" "IsMasterProtein" "P61769" "Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1" "0.000" "False" "27.648" "40" "4" "5" "4" "119" "13.7" "6.52" "21.46" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654" "567" "ENSG00000166710; ENSG00000273686" "B2M" "hsa:567; P01884; P61769; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; ER-Phagosome pathway; Neutrophil degranulation; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "IL-18 signaling pathway" "13" "0" "0.971" "0.986" "0.933" "1.124" "1.084" "1.105" "1.232" "1.233" "0.825" "574.3" "557.7" "566.3" "535.5" "645.6" "622.4" "634.3" "707.7" "708.4" "473.6" "" "" "" "" "" "" "" "" "" "" "509.2" "461.9" "494.1" "400.5" "538.4" "571.8" "536.1" "585.0" "649.7" "473.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421989768094974956" "False" "High" "IsMasterProtein" "Q96BM9" "ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1" "0.000" "False" "27.586" "26" "6" "9" "2" "186" "21.4" "7.77" "30.93" "6" "cell cycle OR cell proliferation;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "127829" "ENSG00000143862" "ARL8A" "B3KXD0; hsa:127829; Q96BM9" "Neutrophil degranulation" "" "1" "3" "1.039" "1.064" "1.103" "1.028" "0.999" "1.095" "1.028" "0.988" "0.664" "924.6" "960.4" "983.8" "1019.9" "950.3" "923.8" "1012.2" "950.3" "913.8" "614.1" "" "" "" "" "" "" "" "" "" "" "819.9" "795.6" "858.4" "762.7" "792.4" "848.6" "855.5" "785.5" "838.1" "614.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "27.570" "26" "6" "10" "6" "212" "23.2" "6.87" "37.07" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "" "4" "0" "1.078" "1.045" "1.040" "1.100" "1.119" "1.089" "1.095" "1.018" "1.105" "621.9" "670.3" "650.0" "646.5" "684.2" "695.8" "677.4" "680.7" "633.0" "687.1" "" "" "" "" "" "" "" "" "" "" "551.5" "555.3" "567.1" "483.5" "570.6" "639.1" "572.5" "562.6" "580.5" "687.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "27.554" "11" "5" "10" "5" "418" "47.3" "5.05" "26.95" "5" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "" "Histone modifications" "1" "0" "1.004" "1.034" "1.068" "1.099" "1.080" "1.055" "1.065" "1.028" "0.719" "827.3" "830.7" "855.2" "884.0" "909.5" "893.5" "873.1" "881.2" "850.8" "594.7" "" "" "" "" "" "" "" "" "" "" "733.6" "688.1" "746.2" "661.1" "758.4" "820.8" "737.9" "728.4" "780.3" "594.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7333138879338488080" "False" "High" "IsMasterProtein" "Q9GZM8" "Nuclear distribution protein nudE-like 1 OS=Homo sapiens OX=9606 GN=NDEL1 PE=1 SV=1" "0.000" "False" "27.529" "13" "4" "6" "1" "345" "38.4" "5.24" "25.01" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "81565" "ENSG00000166579" "NDEL1" "B3KP93; D3DTS0; hsa:81565; J3QT32; Q86T80; Q8TAR7; Q9GZM8; Q9UH50" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9128432651374987381" "False" "High" "IsMasterProtein" "Q9NNW5" "tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "0.000" "False" "27.520" "6" "6" "6" "6" "1121" "121.6" "6.87" "21.95" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "" "5" "0" "1.030" "0.920" "1.007" "0.978" "0.938" "1.072" "0.952" "0.951" "1.266" "211.7" "218.0" "194.8" "213.3" "207.1" "198.5" "227.1" "201.5" "201.4" "268.1" "" "" "" "" "" "" "" "" "" "" "187.8" "180.6" "170.0" "159.5" "172.7" "182.4" "191.9" "166.6" "184.7" "268.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361850666082059512" "False" "High" "IsMasterProtein" "P54252" "Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5" "0.000" "False" "27.519" "12" "3" "4" "3" "361" "41.2" "4.78" "19.45" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02099, Pf02809, Pf16619" "4287" "ENSG00000066427" "ATXN3" "A7LFZ5; D6RDL9; E9PB63; hsa:4287; O15284; O15285; O15286; P54252; Q8N189; Q96TC3; Q96TC4; Q9H3N0" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Josephin domain DUBs" "HDAC6 interactions in the central nervous system" "3" "0" "0.954" "0.891" "0.941" "0.906" "0.876" "0.897" "0.834" "0.945" "2.780" "406.4" "387.5" "361.9" "382.2" "368.0" "355.9" "364.3" "338.8" "383.8" "1129.5" "" "" "" "" "" "" "" "" "" "" "360.3" "321.0" "315.8" "285.8" "306.8" "326.9" "307.9" "280.0" "352.0" "1129.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225315477726738383" "False" "High" "IsMasterProtein" "Q14118" "Dystroglycan 1 OS=Homo sapiens OX=9606 GN=DAG1 PE=1 SV=2" "0.000" "False" "27.478" "7" "6" "6" "6" "895" "97.4" "8.56" "21.73" "6" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05345, Pf05454, Pf18424" "1605" "ENSG00000173402" "DAG1" "A8K6M7; hsa:1605; Q14118; Q969J9" "Regulation of expression of SLITs and ROBOs; ECM proteoglycans; Non-integrin membrane-ECM interactions; O-linked glycosylation; EGR2 and SOX10-mediated initiation of Schwann cell myelination; Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3; Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Acute viral myocarditis; Fragile X syndrome; 13q12.12 copy number variation" "14" "0" "1.024" "0.949" "1.053" "1.011" "1.001" "0.991" "1.019" "1.049" "0.604" "472.2" "483.5" "448.3" "497.3" "477.2" "472.9" "467.9" "481.2" "495.3" "285.3" "" "" "" "" "" "" "" "" "" "" "418.7" "400.5" "391.2" "371.9" "398.0" "434.4" "395.5" "397.8" "454.2" "285.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630432664316486602" "False" "High" "IsMasterProtein" "Q16563" "Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1" "0.000" "False" "27.450" "22" "4" "9" "4" "259" "28.5" "8.43" "39.75" "4" "cell-cell signaling" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf01284" "6856" "ENSG00000008282" "SYPL1" "A4D0R2; hsa:6856; Q16563; Q96AR8" "" "" "0" "0" "1.058" "1.008" "1.011" "1.079" "1.055" "1.104" "1.006" "1.085" "1.083" "773.5" "818.6" "779.4" "782.1" "834.7" "816.4" "853.8" "777.8" "839.2" "837.9" "" "" "" "" "" "" "" "" "" "" "686.0" "678.1" "680.0" "584.9" "696.0" "749.9" "721.6" "642.9" "769.6" "837.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629432555354117988" "False" "High" "IsMasterProtein" "P78537" "Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Homo sapiens OX=9606 GN=BLOC1S1 PE=1 SV=2" "0.000" "False" "27.446" "29" "4" "5" "4" "153" "17.3" "9.33" "20.50" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "" "Pf06320" "2647" "ENSG00000135441" "BLOC1S1" "A1L4Q9; hsa:2647; P78537; Q6NZ45" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "Alstrom syndrome" "3" "0" "0.975" "0.912" "0.950" "0.981" "0.907" "0.907" "0.934" "0.933" "1.010" "995.8" "970.5" "908.1" "946.4" "976.3" "903.0" "903.3" "930.4" "928.6" "1005.3" "" "" "" "" "" "" "" "" "" "" "883.0" "803.9" "792.3" "707.8" "814.1" "829.5" "763.4" "769.0" "851.6" "1005.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-411341991637906360" "False" "High" "IsMasterProtein" "P27448" "MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5" "0.000" "False" "27.435" "9" "7" "9" "7" "753" "84.4" "9.57" "26.15" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "4140" "ENSG00000075413" "MARK3" "A0A0A0MQR8; A0A0A0MST9; A0A0A0MT23; hsa:4140; O60219; P27448; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Complement system in neuronal development and plasticity" "10" "0" "0.912" "1.010" "1.012" "0.984" "1.016" "1.054" "0.937" "1.116" "3.004" "479.9" "437.6" "484.8" "485.7" "472.3" "487.4" "505.7" "449.7" "535.6" "1441.7" "" "" "" "" "" "" "" "" "" "" "425.6" "362.5" "423.0" "363.2" "393.8" "447.7" "427.4" "371.7" "491.2" "1441.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1239746035430338710" "False" "High" "IsMasterProtein" "Q2T9J0" "Peroxisomal leader peptide-processing protease OS=Homo sapiens OX=9606 GN=TYSND1 PE=1 SV=3" "0.000" "False" "27.423" "9" "4" "4" "4" "566" "59.3" "6.20" "18.24" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf13365" "219743" "ENSG00000156521" "TYSND1" "hsa:219743; Q2T9J0; Q5SQT4; Q5SQU1; Q8N6H2; Q96AR5" "TYSND1 cleaves peroxisomal proteins" "" "2" "0" "0.917" "0.838" "0.990" "0.922" "0.879" "0.868" "0.858" "0.751" "0.652" "364.7" "334.5" "305.8" "361.2" "336.4" "320.8" "316.6" "313.0" "274.0" "238.0" "" "" "" "" "" "" "" "" "" "" "323.4" "277.1" "266.8" "270.1" "280.5" "294.7" "267.5" "258.7" "251.3" "238.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "High" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.000" "False" "27.372" "18" "6" "8" "6" "357" "39.3" "8.10" "30.26" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.023" "0.872" "0.998" "0.907" "0.931" "0.917" "0.983" "0.870" "0.740" "685.0" "701.0" "597.1" "683.9" "621.1" "637.6" "628.4" "673.6" "596.1" "507.2" "" "" "" "" "" "" "" "" "" "" "607.5" "580.6" "521.0" "511.4" "517.9" "585.7" "531.1" "556.7" "546.7" "507.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4972524321603701932" "False" "High" "IsMasterProtein" "Q8IW35" "Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1" "0.000" "False" "27.351" "6" "5" "8" "5" "865" "96.9" "5.02" "27.62" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14580" "79598" "ENSG00000182504" "CEP97" "B5MDY8; hsa:79598; Q8IW35; Q8NA71; Q9H5T9" "Anchoring of the basal body to the plasma membrane; RHOV GTPase cycle" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "5" "0" "1.024" "0.887" "1.064" "0.901" "0.907" "0.978" "0.834" "0.913" "3.941" "523.7" "536.1" "464.7" "557.4" "472.1" "474.8" "512.0" "436.6" "477.9" "2063.6" "" "" "" "" "" "" "" "" "" "" "464.4" "444.1" "405.5" "416.9" "393.7" "436.1" "432.7" "360.9" "438.3" "2063.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.000" "False" "27.309" "17" "4" "5" "4" "254" "27.9" "6.83" "21.72" "4" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "Sulfide oxidation to sulfate" "" "1" "0" "1.054" "1.056" "1.102" "1.113" "1.103" "1.132" "1.089" "1.022" "0.564" "781.1" "823.0" "824.6" "860.7" "869.6" "861.9" "884.3" "850.8" "798.3" "440.4" "" "" "" "" "" "" "" "" "" "" "692.7" "681.8" "719.5" "643.7" "725.1" "791.8" "747.4" "703.3" "732.2" "440.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4237214886957203676" "False" "High" "IsMasterProtein" "P51956" "Serine/threonine-protein kinase Nek3 OS=Homo sapiens OX=9606 GN=NEK3 PE=1 SV=2" "0.000" "False" "27.287" "12" "6" "9" "6" "506" "57.7" "7.17" "31.49" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "4752" "ENSG00000136098" "NEK3" "A8K2J4; hsa:4752; P51956; Q5TAP2; Q8J023; Q8WUN5" "" "Prolactin signaling pathway" "1" "0" "1.024" "0.938" "0.956" "0.986" "0.939" "0.970" "0.914" "0.932" "0.879" "306.5" "313.8" "287.6" "293.1" "302.3" "287.9" "297.4" "280.1" "285.7" "269.3" "" "" "" "" "" "" "" "" "" "" "271.8" "259.9" "251.0" "219.2" "252.1" "264.4" "251.3" "231.6" "262.0" "269.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1882334441137329574" "False" "High" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "0.000" "False" "27.251" "9" "7" "8" "7" "856" "95.7" "6.92" "30.98" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "1.000" "0.983" "0.990" "0.958" "1.021" "0.937" "0.751" "0.874" "3.406" "1022.9" "1022.7" "1005.3" "1012.5" "980.3" "1044.0" "958.7" "768.6" "894.0" "3483.7" "" "" "" "" "" "" "" "" "" "" "907.0" "847.2" "877.1" "757.2" "817.4" "959.0" "810.3" "635.3" "819.9" "3483.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "27.243" "21" "7" "9" "7" "307" "34.9" "9.57" "26.52" "7" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.050" "0.934" "0.985" "0.913" "0.883" "0.905" "0.893" "0.957" "0.431" "698.8" "733.8" "652.7" "688.2" "637.9" "617.1" "632.5" "624.4" "669.1" "301.3" "" "" "" "" "" "" "" "" "" "" "619.7" "607.8" "569.5" "514.6" "531.9" "566.8" "534.6" "516.1" "613.6" "301.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1713406968265840354" "False" "High" "IsMasterProtein" "O60825" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2 PE=1 SV=2" "0.000" "False" "27.237" "13" "7" "8" "3" "505" "58.4" "8.38" "27.27" "7" "other metabolic processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5208" "ENSG00000123836" "PFKFB2" "hsa:5208; O60824; O60825; Q5VVQ3; Q5VVQ4; Q9H3P1" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "3" "1" "1.110" "1.050" "1.140" "1.115" "1.092" "1.143" "1.160" "1.180" "1.012" "466.1" "517.2" "489.3" "531.5" "519.7" "509.2" "532.7" "540.7" "550.2" "471.9" "" "" "" "" "" "" "" "" "" "" "413.4" "428.5" "426.9" "397.5" "433.4" "467.8" "450.2" "446.9" "504.6" "471.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "531745898464633118" "False" "High" "IsMasterProtein" "Q6P3S6" "F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1" "0.000" "False" "27.232" "11" "7" "8" "7" "717" "77.8" "7.43" "26.59" "7" "" "other cell component" "other molecular function" "Pf12937, Pf13415, Pf13854" "54455" "ENSG00000037637; ENSG00000291375" "FBXO42" "B3KP30; hsa:54455; Q5TEU8; Q6P3S6; Q86XI0; Q8N3N4; Q8N5F8; Q9BRM0; Q9P2L4" "" "" "0" "0" "1.045" "1.078" "1.118" "1.039" "1.037" "1.103" "1.113" "1.064" "0.693" "206.6" "215.9" "222.8" "230.9" "214.6" "214.3" "227.8" "229.9" "219.8" "143.2" "" "" "" "" "" "" "" "" "" "" "183.2" "178.8" "194.4" "172.7" "179.0" "196.8" "192.6" "190.1" "201.6" "143.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4378027519318782833" "False" "High" "IsMasterProtein" "Q9H425" "Uncharacterized protein C1orf198 OS=Homo sapiens OX=9606 GN=C1orf198 PE=1 SV=1" "0.000" "False" "27.223" "17" "5" "5" "5" "327" "36.3" "5.72" "19.78" "5" "" "cytosol" "" "Pf15797" "84886" "ENSG00000119280" "C1orf198" "A8K8R8; B3KTW1; G5EA08; hsa:84886; Q9H425" "" "" "0" "0" "0.900" "0.974" "0.976" "0.940" "0.938" "0.924" "1.007" "0.956" "0.436" "637.5" "573.5" "621.2" "622.4" "599.0" "598.0" "589.2" "642.1" "609.5" "277.7" "" "" "" "" "" "" "" "" "" "" "565.3" "475.1" "542.1" "465.5" "499.5" "549.4" "498.0" "530.8" "559.0" "277.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6553224162090552303" "False" "High" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "0.000" "False" "27.195" "27" "5" "7" "5" "225" "26.0" "5.78" "27.43" "5" "" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "0.916" "0.975" "0.874" "0.948" "0.947" "0.967" "0.928" "0.980" "0.657" "781.1" "715.4" "761.9" "682.8" "740.2" "740.0" "755.2" "724.6" "765.2" "513.0" "" "" "" "" "" "" "" "" "" "" "692.7" "592.6" "664.8" "510.7" "617.2" "679.8" "638.3" "598.9" "701.8" "513.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "27.178" "23" "6" "7" "6" "301" "34.5" "4.82" "28.84" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "Processing of DNA double-strand break ends" "" "1" "0" "1.015" "1.024" "1.057" "1.079" "1.044" "1.087" "1.116" "1.191" "1.220" "801.9" "813.9" "821.3" "847.5" "865.2" "837.0" "871.5" "894.7" "954.7" "978.2" "" "" "" "" "" "" "" "" "" "" "711.1" "674.2" "716.7" "633.8" "721.4" "768.8" "736.6" "739.5" "875.6" "978.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5394761207929622698" "False" "High" "IsMasterProtein" "O14917" "Protocadherin-17 OS=Homo sapiens OX=9606 GN=PCDH17 PE=1 SV=2" "0.000" "False" "27.173" "5" "4" "5" "4" "1159" "126.2" "5.19" "23.32" "4" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028, Pf08266" "27253" "ENSG00000118946" "PCDH17" "A8K1R5; hsa:27253; O14917; Q5VVW9; Q5VVX0" "" "" "0" "0" "1.002" "1.075" "1.106" "0.982" "1.043" "1.028" "1.004" "0.991" "0.459" "347.0" "347.8" "373.0" "383.7" "340.7" "361.8" "356.7" "348.4" "343.8" "159.4" "" "" "" "" "" "" "" "" "" "" "307.7" "288.1" "325.4" "287.0" "284.1" "332.4" "301.5" "288.0" "315.3" "159.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175169128914004892" "False" "High" "IsMasterProtein" "Q30154" "HLA class II histocompatibility antigen, DR beta 5 chain OS=Homo sapiens OX=9606 GN=HLA-DRB5 PE=1 SV=1" "0.000" "False" "27.170" "26" "6" "8" "3" "266" "30.0" "6.93" "30.45" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3127" "ENSG00000198502" "HLA-DRB5" "B2RBV6; C7C4X3; hsa:3127; O00157; O00283; O46700; Q29703; Q29787; Q29788; Q30126; Q30150; Q30154; Q30199; Q6SJR2; Q7M2H9; Q8HWS7; Q8WLR5; Q9MY54; Q9XRX6" "Interferon gamma signaling; MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling" "Allograft rejection; Ebola virus infection in host; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "11" "1" "1.034" "1.055" "1.034" "1.130" "0.956" "1.065" "1.130" "1.425" "0.736" "369.4" "381.9" "389.7" "381.9" "417.3" "353.3" "393.4" "417.5" "526.4" "271.9" "" "" "" "" "" "" "" "" "" "" "327.6" "316.4" "340.1" "285.6" "348.0" "324.5" "332.5" "345.1" "482.8" "271.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "27.169" "19" "4" "6" "4" "261" "30.0" "7.06" "30.45" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Vitamin B6 activation to pyridoxal phosphate" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "3" "0" "1.006" "1.011" "1.209" "1.100" "1.028" "1.064" "1.073" "0.975" "0.629" "328.4" "330.3" "332.1" "397.0" "361.1" "337.6" "349.4" "352.3" "320.1" "206.6" "" "" "" "" "" "" "" "" "" "" "291.2" "273.6" "289.7" "296.9" "301.1" "310.1" "295.3" "291.2" "293.5" "206.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6002739480164065296" "False" "High" "IsMasterProtein" "Q14137" "Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2" "0.000" "False" "27.166" "7" "5" "6" "5" "746" "83.6" "6.19" "23.55" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08145" "23246" "ENSG00000261236" "BOP1" "hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.994" "0.881" "1.080" "0.955" "0.954" "0.925" "0.751" "0.827" "2.704" "423.3" "420.6" "373.0" "457.2" "404.3" "403.7" "391.6" "317.8" "350.2" "1144.6" "" "" "" "" "" "" "" "" "" "" "375.3" "348.4" "325.4" "341.9" "337.2" "370.8" "331.0" "262.7" "321.2" "1144.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.000" "False" "27.165" "16" "7" "9" "7" "469" "51.3" "5.58" "31.02" "7" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "25" "0" "1.014" "1.072" "1.037" "1.050" "1.078" "0.829" "0.761" "0.783" "1.501" "1237.9" "1255.4" "1327.4" "1283.6" "1299.7" "1334.8" "1026.0" "942.6" "969.5" "1858.5" "" "" "" "" "" "" "" "" "" "" "1097.8" "1039.9" "1158.3" "960.0" "1083.8" "1226.2" "867.2" "779.1" "889.1" "1858.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2347983332977388865" "False" "High" "IsMasterProtein" "Q9H900" "Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2" "0.000" "False" "27.041" "10" "6" "7" "6" "591" "67.2" "6.27" "20.59" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf09817" "55055" "ENSG00000174442" "ZWILCH" "B3KVB8; hsa:55055; Q6N049; Q8N404; Q96SY7; Q9H900; Q9NWG7" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.051" "1.000" "1.048" "1.080" "1.079" "1.092" "0.990" "1.032" "2.095" "961.6" "1010.7" "961.8" "1007.9" "1038.9" "1037.1" "1049.9" "952.2" "992.7" "2014.4" "" "" "" "" "" "" "" "" "" "" "852.7" "837.2" "839.3" "753.7" "866.3" "952.7" "887.3" "787.1" "910.4" "2014.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "27.009" "7" "4" "6" "4" "911" "99.9" "7.55" "25.57" "4" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "Envelope proteins and their potential roles in EDMD physiopathology" "12" "0" "1.074" "1.006" "1.107" "1.009" "1.061" "1.010" "1.138" "1.094" "0.558" "295.5" "317.3" "297.4" "327.1" "298.2" "313.6" "298.6" "336.3" "323.4" "164.8" "" "" "" "" "" "" "" "" "" "" "262.1" "262.8" "259.5" "244.6" "248.7" "288.1" "252.4" "278.0" "296.6" "164.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4410933930265088231" "False" "High" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "0.000" "False" "26.975" "40" "5" "7" "5" "111" "13.5" "8.78" "25.26" "5" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "0.980" "1.009" "0.989" "0.995" "1.057" "0.784" "0.850" "0.820" "0.486" "1138.3" "1115.3" "1148.3" "1125.2" "1132.5" "1202.9" "892.8" "967.0" "932.8" "553.1" "" "" "" "" "" "" "" "" "" "" "1009.4" "923.8" "1001.9" "841.5" "944.4" "1105.0" "754.6" "799.3" "855.5" "553.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449078799256658420" "False" "High" "IsMasterProtein" "Q53FA7" "Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2" "0.000" "False" "26.959" "14" "5" "6" "5" "332" "35.5" "7.17" "20.45" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf00107, Pf08240" "9540" "ENSG00000115129" "TP53I3" "D6W533; hsa:9540; O14679; O14685; Q38G78; Q53FA7; Q6JLE7; Q9BWB8" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "p53 transcriptional gene network; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "3" "0" "0.981" "0.990" "1.009" "1.094" "1.025" "1.029" "1.047" "0.950" "0.504" "503.9" "494.5" "498.8" "508.4" "551.4" "516.5" "518.3" "527.4" "478.5" "254.2" "" "" "" "" "" "" "" "" "" "" "446.9" "409.6" "435.2" "380.2" "459.8" "474.4" "438.1" "435.9" "438.8" "254.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8899762439150821704" "False" "High" "IsMasterProtein" "Q9H9Q4" "Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1" "0.000" "False" "26.942" "14" "3" "4" "3" "299" "33.3" "5.97" "18.20" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09302" "79840" "ENSG00000187736" "NHEJ1" "B8ZZA4; hsa:79840; Q4ZFW7; Q6IA64; Q96JS9; Q9H9Q4" "Nonhomologous End-Joining (NHEJ)" "Non-homologous end joining; DNA repair pathways, full network" "3" "0" "1.085" "1.077" "1.036" "1.058" "1.105" "1.066" "1.271" "1.119" "0.647" "294.0" "318.8" "316.5" "304.5" "311.1" "324.8" "313.3" "373.6" "329.0" "190.2" "" "" "" "" "" "" "" "" "" "" "260.7" "264.1" "276.2" "227.7" "259.4" "298.3" "264.8" "308.8" "301.8" "190.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "26.937" "54" "5" "10" "5" "97" "10.9" "9.41" "37.20" "5" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "0.957" "0.924" "0.915" "0.938" "0.993" "0.917" "0.941" "0.954" "0.457" "856.8" "820.2" "791.4" "784.1" "803.9" "850.7" "785.5" "806.3" "817.4" "391.3" "" "" "" "" "" "" "" "" "" "" "759.8" "679.4" "690.5" "586.4" "670.4" "781.5" "663.9" "666.4" "749.7" "391.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-233875038678641110" "False" "High" "IsMasterProtein" "Q7Z5U6" "WD repeat-containing protein 53 OS=Homo sapiens OX=9606 GN=WDR53 PE=1 SV=1" "0.000" "False" "26.912" "18" "5" "5" "4" "358" "39.0" "6.52" "17.09" "5" "" "" "" "Pf00400, Pf12894" "348793" "ENSG00000185798" "WDR53" "A0MNP1; hsa:348793; Q7Z5U6" "" "3q29 copy number variation syndrome" "1" "1" "1.048" "0.968" "1.076" "1.007" "1.085" "1.101" "1.157" "1.061" "0.677" "490.7" "514.3" "475.1" "527.9" "494.4" "532.6" "540.5" "567.7" "520.6" "332.2" "" "" "" "" "" "" "" "" "" "" "435.2" "426.0" "414.5" "394.8" "412.3" "489.2" "456.8" "469.2" "477.5" "332.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8397270974056062959" "False" "High" "IsMasterProtein" "Q9NRL3" "Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2" "0.000" "False" "26.904" "11" "9" "11" "7" "753" "80.5" "5.40" "37.03" "9" "" "other membranes;other cell component" "other molecular function" "Pf00400, Pf08232" "29888" "ENSG00000090372" "STRN4" "A0A024R0V2; B4DQH7; F8VYA6; hsa:29888; Q8NE53; Q9NRL3" "" "" "0" "0" "1.060" "0.985" "1.102" "1.025" "1.030" "1.002" "0.962" "0.978" "1.153" "287.0" "304.3" "282.6" "316.2" "294.3" "295.6" "287.6" "276.0" "280.6" "331.1" "" "" "" "" "" "" "" "" "" "" "254.5" "252.1" "246.6" "236.5" "245.4" "271.6" "243.0" "228.1" "257.4" "331.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8978349436204480078" "False" "High" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "0.000" "False" "26.892" "14" "5" "6" "5" "414" "44.7" "6.19" "26.59" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694, Pf20910" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "" "MECP2 and associated Rett syndrome; HDAC6 interactions in the central nervous system" "2" "0" "0.953" "0.840" "0.994" "0.905" "0.910" "0.941" "0.144" "0.870" "15.155" "584.1" "556.7" "490.8" "580.6" "528.6" "531.4" "549.4" "84.2" "508.2" "8851.9" "" "" "" "" "" "" "" "" "" "" "518.0" "461.2" "428.3" "434.2" "440.7" "488.2" "464.4" "69.6" "466.1" "8851.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8122664404387137367" "False" "High" "IsMasterProtein" "Q96JP5" "E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1" "0.000" "False" "26.880" "11" "4" "6" "4" "570" "63.4" "7.36" "22.91" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00096" "80829" "ENSG00000186660" "ZFP91" "A6NHC4; A8MSG7; Q86V47; Q96JP4; Q96JP5; Q96QA3" "" "" "0" "0" "0.951" "1.004" "1.104" "0.966" "0.965" "1.007" "0.931" "0.894" "0.782" "426.6" "405.7" "428.2" "471.1" "411.9" "411.7" "429.7" "397.0" "381.4" "333.4" "" "" "" "" "" "" "" "" "" "" "378.3" "336.1" "373.6" "352.3" "343.5" "378.2" "363.2" "328.1" "349.8" "333.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256514097134295092" "False" "High" "IsMasterProtein" "Q13546" "Receptor-interacting serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=RIPK1 PE=1 SV=3" "0.000" "False" "26.825" "10" "5" "5" "5" "671" "75.9" "6.33" "20.77" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00531, Pf07714" "8737" "ENSG00000137275" "RIPK1" "A0AV89; B2RAG1; B4E3F9; hsa:8737; Q13180; Q13546; Q59H33" "Potential therapeutics for SARS; Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; Ovarian tumor domain proteases; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis; RIP-mediated NFkB activation via ZBP1; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis; SARS-CoV-1-mediated effects on programmed cell death" "Apoptosis modulation and signaling; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Cytosolic DNA-sensing pathway; Host-pathogen interaction of human coronaviruses - interferon induction; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Toll-like receptor signaling pathway" "35" "0" "1.274" "1.011" "1.242" "1.122" "0.978" "1.197" "0.805" "1.068" "6.448" "167.3" "213.1" "169.1" "207.7" "187.7" "163.7" "200.2" "134.6" "178.6" "1078.6" "" "" "" "" "" "" "" "" "" "" "148.3" "176.5" "147.5" "155.4" "156.5" "150.3" "169.2" "111.3" "163.8" "1078.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1940772277811891477" "False" "High" "IsMasterProtein" "Q96PM5" "RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1" "0.000" "False" "26.785" "24" "6" "7" "6" "261" "30.1" "6.71" "22.64" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05495, Pf13639, Pf14599" "25898" "ENSG00000163743" "RCHY1" "B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PM5; Q96PR5" "Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH" "Measles virus infection" "3" "0" "0.966" "0.989" "0.878" "0.961" "1.050" "0.921" "1.027" "0.984" "0.664" "500.5" "483.6" "495.2" "439.5" "481.2" "525.7" "460.8" "513.9" "492.6" "332.5" "" "" "" "" "" "" "" "" "" "" "443.8" "400.6" "432.1" "328.7" "401.2" "482.9" "389.5" "424.8" "451.8" "332.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7807637693933670842" "False" "High" "IsMasterProtein" "Q8NB91" "Fanconi anemia group B protein OS=Homo sapiens OX=9606 GN=FANCB PE=1 SV=1" "0.000" "False" "26.772" "9" "8" "8" "8" "859" "97.7" "7.61" "25.13" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "" "2187" "ENSG00000181544" "FANCB" "B2RMZ4; hsa:2187; Q7Z2U2; Q86XG1; Q8NB91" "Fanconi Anemia Pathway; PKR-mediated signaling" "DNA repair pathways, full network" "3" "0" "0.968" "0.904" "1.067" "0.985" "0.923" "0.965" "1.004" "0.904" "0.636" "772.7" "747.7" "698.4" "824.6" "761.3" "713.0" "745.9" "775.4" "698.3" "491.1" "" "" "" "" "" "" "" "" "" "" "685.2" "619.3" "609.3" "616.7" "634.8" "654.9" "630.4" "640.9" "640.4" "491.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "High" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.000" "False" "26.768" "41" "5" "10" "5" "101" "11.5" "9.33" "35.51" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "HATs acetylate histones" "" "1" "0" "0.921" "0.942" "0.921" "0.932" "0.943" "0.926" "0.945" "0.930" "0.440" "1078.0" "993.1" "1015.0" "993.2" "1004.6" "1017.0" "998.4" "1018.8" "1002.3" "474.7" "" "" "" "" "" "" "" "" "" "" "956.0" "822.7" "885.7" "742.8" "837.7" "934.2" "843.8" "842.1" "919.2" "474.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "26.761" "39" "4" "11" "4" "100" "11.4" "7.34" "33.57" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Neutrophil degranulation; ER-Phagosome pathway; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "8" "0" "0.974" "0.949" "1.047" "1.008" "0.971" "0.973" "1.034" "1.085" "0.694" "846.7" "824.7" "803.6" "886.7" "853.5" "822.3" "824.2" "875.7" "918.9" "587.6" "" "" "" "" "" "" "" "" "" "" "750.9" "683.1" "701.2" "663.1" "711.7" "755.4" "696.6" "723.8" "842.7" "587.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "26.709" "21" "5" "7" "5" "257" "29.4" "9.67" "32.17" "5" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "1.029" "0.996" "0.940" "0.920" "0.867" "0.575" "0.611" "0.612" "0.201" "1658.5" "1706.6" "1652.4" "1558.6" "1525.6" "1437.7" "953.5" "1014.1" "1014.7" "333.4" "" "" "" "" "" "" "" "" "" "" "1470.8" "1413.7" "1441.8" "1165.7" "1272.2" "1320.7" "805.8" "838.2" "930.7" "333.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8837747805973553035" "False" "High" "IsMasterProtein" "Q12778" "Forkhead box protein O1 OS=Homo sapiens OX=9606 GN=FOXO1 PE=1 SV=2" "0.000" "False" "26.674" "7" "4" "5" "4" "655" "69.6" "6.77" "21.63" "4" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16675, Pf16676" "2308" "ENSG00000150907" "FOXO1" "hsa:2308; O43523; Q12778; Q5VYC7; Q6NSK6" "Constitutive Signaling by AKT1 E17K in Cancer; MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; AKT-mediated inactivation of FOXO1A" "Androgen receptor signaling pathway; Energy metabolism; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Adipogenesis; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Copper homeostasis; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; NAD metabolism, sirtuins and aging; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; White fat cell differentiation; Somatroph axis (GH) and its relationship to dietary restriction and aging; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Kynurenine pathway and links to cell senescence; FOXA2 pathway; Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Warburg effect modulated by deubiquitinating enzymes and their substrates; Extrafollicular and follicular B cell activation by SARS-CoV-2; Primary ovarian insufficiency; Rubinstein-Taybi syndrome 1; ErbB signaling pathway" "52" "0" "0.910" "0.917" "0.920" "0.802" "0.772" "0.746" "0.776" "0.942" "1.798" "497.4" "452.7" "456.0" "457.8" "399.0" "384.0" "371.0" "385.8" "468.4" "894.2" "" "" "" "" "" "" "" "" "" "" "441.1" "375.0" "397.9" "342.4" "332.7" "352.7" "313.5" "318.9" "429.5" "894.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "High" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.000" "False" "26.637" "51" "4" "8" "4" "85" "9.8" "6.81" "28.10" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "18" "0" "1.072" "0.951" "1.129" "0.997" "0.945" "1.066" "1.002" "1.018" "0.666" "563.0" "603.7" "535.2" "635.4" "561.4" "532.1" "600.4" "564.2" "573.1" "374.7" "" "" "" "" "" "" "" "" "" "" "499.3" "500.1" "467.0" "475.2" "468.1" "488.8" "507.4" "466.4" "525.6" "374.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.000" "False" "26.625" "36" "5" "7" "5" "155" "17.6" "5.67" "28.54" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "" "17q12 copy number variation syndrome" "1" "0" "0.930" "0.918" "0.932" "0.909" "0.942" "0.845" "0.944" "0.909" "0.399" "815.1" "758.4" "748.4" "759.6" "741.3" "768.2" "688.7" "769.6" "740.5" "324.9" "" "" "" "" "" "" "" "" "" "" "722.8" "628.2" "653.0" "568.1" "618.1" "705.7" "582.1" "636.1" "679.1" "324.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7553626301853439744" "False" "High" "IsMasterProtein" "P63146" "Ubiquitin-conjugating enzyme E2 B OS=Homo sapiens OX=9606 GN=UBE2B PE=1 SV=1" "0.000" "False" "26.616" "32" "3" "5" "2" "152" "17.3" "5.01" "21.26" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00179" "7320" "ENSG00000119048" "UBE2B" "B2R503; D3DQA2; hsa:7320; P23567; P63146; Q4PJ15; Q9D0J6" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Recognition of DNA damage by PCNA-containing replication complex" "Proteasome degradation; Male infertility" "6" "0" "1.045" "1.097" "1.024" "1.064" "1.204" "1.064" "1.059" "1.060" "1.070" "546.4" "571.1" "599.5" "559.7" "581.3" "657.6" "581.5" "578.8" "579.5" "584.9" "" "" "" "" "" "" "" "" "" "" "484.6" "473.1" "523.1" "418.6" "484.7" "604.1" "491.5" "478.4" "531.4" "584.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2339365815424834793" "False" "High" "IsMasterProtein" "Q9Y217" "Myotubularin-related protein 6 OS=Homo sapiens OX=9606 GN=MTMR6 PE=1 SV=3" "0.000" "False" "26.609" "9" "5" "6" "5" "621" "71.9" "7.66" "23.95" "5" "protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06602, Pf21098" "9107" "ENSG00000139505" "MTMR6" "B2RBB5; B3KSB4; hsa:9107; Q5JRG6; Q86TB7; Q86YH4; Q96P80; Q9Y217" "Synthesis of PIPs at the plasma membrane" "8p23.1 copy number variation syndrome" "2" "0" "1.118" "0.903" "0.974" "0.939" "0.990" "0.833" "0.710" "0.863" "2.939" "490.0" "547.8" "442.6" "477.3" "459.9" "485.2" "408.2" "347.9" "422.8" "1440.1" "" "" "" "" "" "" "" "" "" "" "434.5" "453.8" "386.2" "356.9" "383.5" "445.7" "345.0" "287.6" "387.7" "1440.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6395227692188504005" "False" "High" "IsMasterProtein" "Q7Z3K3" "Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2" "0.000" "False" "26.607" "4" "4" "4" "4" "1410" "155.2" "7.40" "17.14" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03184, Pf03221" "23126" "ENSG00000143442" "POGZ" "B4DTP8; B4DYL9; B7ZBY5; E9PM80; hsa:23126; O75049; Q3LIC4; Q5SZS1; Q5SZS2; Q5SZS3; Q5SZS4; Q7Z3K3; Q8TDZ7; Q9Y4X7" "" "" "0" "0" "0.970" "1.014" "0.965" "1.030" "1.094" "0.902" "0.880" "0.993" "1.635" "420.6" "407.8" "426.3" "405.7" "433.2" "460.1" "379.5" "370.1" "417.6" "687.8" "" "" "" "" "" "" "" "" "" "" "373.0" "337.8" "372.0" "303.4" "361.3" "422.7" "320.8" "305.9" "383.0" "687.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8061362112935544067" "False" "High" "IsMasterProtein" "P43121" "Cell surface glycoprotein MUC18 OS=Homo sapiens OX=9606 GN=MCAM PE=1 SV=2" "0.000" "False" "26.532" "7" "4" "6" "4" "646" "71.6" "5.76" "21.08" "4" "cell adhesion;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "" "Pf07686, Pf08205, Pf13927" "4162" "ENSG00000076706" "MCAM" "hsa:4162; O95812; P43121; Q59E86; Q6PHR3; Q6ZTR2" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle" "" "9" "0" "1.126" "0.941" "1.090" "1.126" "1.000" "1.075" "1.046" "1.057" "0.538" "144.7" "162.9" "136.2" "157.7" "163.0" "144.7" "155.5" "151.4" "153.0" "77.9" "" "" "" "" "" "" "" "" "" "" "128.3" "135.0" "118.8" "118.0" "135.9" "132.9" "131.4" "125.1" "140.3" "77.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.000" "False" "26.521" "21" "4" "5" "4" "192" "20.7" "9.91" "20.69" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.001" "0.894" "0.935" "0.948" "0.939" "0.985" "0.939" "0.822" "1.875" "228.8" "229.0" "204.5" "213.9" "216.9" "214.7" "225.3" "214.7" "188.0" "428.9" "" "" "" "" "" "" "" "" "" "" "202.9" "189.7" "178.5" "160.0" "180.8" "197.2" "190.4" "177.5" "172.4" "428.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8157399823022384529" "False" "High" "IsMasterProtein" "Q99567" "Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2" "0.000" "False" "26.480" "9" "6" "6" "6" "741" "83.5" "5.69" "26.03" "6" "other metabolic processes;transport" "cytosol;nucleus" "other molecular function" "Pf10168" "4927" "ENSG00000108559" "NUP88" "D3DTM2; hsa:4927; Q99567; Q9BWE5" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; tRNA processing in the nucleus; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" "Ciliary landscape" "29" "0" "1.140" "0.954" "1.049" "0.989" "0.887" "1.099" "0.617" "0.988" "8.172" "346.4" "395.0" "330.4" "363.3" "342.5" "307.4" "380.8" "213.8" "342.1" "2830.7" "" "" "" "" "" "" "" "" "" "" "307.2" "327.2" "288.2" "271.7" "285.6" "282.4" "321.8" "176.7" "313.8" "2830.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1411414456407117859" "False" "High" "IsMasterProtein" "Q7Z6K3" "Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2" "0.000" "False" "26.460" "14" "5" "5" "5" "402" "46.4" "6.99" "22.25" "5" "" "other cell component" "other molecular function" "Pf01239" "375743" "ENSG00000188647" "PTAR1" "hsa:375743; Q5T7V5; Q5T7V6; Q7Z6K3" "" "" "0" "0" "0.995" "0.926" "0.937" "0.930" "1.032" "1.052" "1.009" "0.946" "0.709" "527.4" "524.6" "488.2" "494.1" "490.7" "544.3" "554.8" "532.3" "498.8" "373.7" "" "" "" "" "" "" "" "" "" "" "467.7" "434.6" "426.0" "369.5" "409.2" "500.0" "468.9" "440.0" "457.5" "373.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.000" "False" "26.455" "23" "4" "7" "4" "167" "19.5" "4.49" "26.40" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "tRNA processing in the nucleus" "" "1" "0" "1.001" "0.945" "1.000" "1.021" "1.052" "0.955" "1.038" "0.935" "0.614" "1623.6" "1625.2" "1534.8" "1623.1" "1657.4" "1707.4" "1550.1" "1685.0" "1517.7" "996.9" "" "" "" "" "" "" "" "" "" "" "1439.7" "1346.2" "1339.2" "1213.9" "1382.1" "1568.4" "1310.1" "1392.8" "1392.0" "996.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6853827814974880096" "False" "High" "IsMasterProtein" "P52747" "Zinc finger protein 143 OS=Homo sapiens OX=9606 GN=ZNF143 PE=1 SV=2" "0.000" "False" "26.438" "11" "5" "5" "5" "638" "68.9" "6.05" "20.38" "5" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7702" "ENSG00000166478" "ZNF143" "A8K518; B4DLY5; E7ER34; hsa:7702; O75559; P52747; Q8WUK9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "IL-18 signaling pathway" "4" "0" "0.945" "0.930" "0.644" "0.761" "0.847" "0.806" "0.925" "1.141" "1.763" "109.1" "103.1" "101.4" "70.3" "83.0" "92.4" "87.9" "100.9" "124.5" "192.3" "" "" "" "" "" "" "" "" "" "" "96.7" "85.4" "88.5" "52.6" "69.3" "84.9" "74.3" "83.4" "114.2" "192.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "26.436" "13" "6" "8" "6" "489" "52.1" "5.53" "23.47" "6" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.026" "1.041" "1.060" "0.985" "1.042" "1.029" "1.027" "0.980" "0.754" "588.1" "603.3" "612.0" "623.5" "579.1" "612.9" "605.4" "604.2" "576.6" "443.7" "" "" "" "" "" "" "" "" "" "" "521.5" "499.7" "534.0" "466.3" "482.9" "563.0" "511.7" "499.4" "528.8" "443.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966117974293097362" "False" "High" "IsMasterProtein" "Q9UHL4" "Dipeptidyl peptidase 2 OS=Homo sapiens OX=9606 GN=DPP7 PE=1 SV=3" "0.000" "False" "26.434" "14" "6" "6" "6" "492" "54.3" "6.32" "22.71" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "29952" "ENSG00000176978" "DPP7" "A8K7U7; hsa:29952; Q5VSF1; Q969X4; Q9UHL4" "Neutrophil degranulation" "" "1" "0" "1.027" "0.977" "0.913" "1.052" "1.019" "0.964" "1.032" "0.930" "0.650" "414.6" "425.6" "404.9" "378.4" "436.2" "422.6" "399.6" "427.9" "385.5" "269.6" "" "" "" "" "" "" "" "" "" "" "367.6" "352.5" "353.3" "283.0" "363.7" "388.2" "337.8" "353.7" "353.6" "269.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "26.391" "28" "8" "8" "8" "352" "40.2" "5.47" "25.30" "8" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling" "" "2" "0" "1.097" "0.960" "1.016" "0.987" "1.068" "1.035" "0.804" "0.987" "4.284" "337.6" "370.4" "324.0" "343.1" "333.3" "360.7" "349.3" "271.6" "333.3" "1446.4" "" "" "" "" "" "" "" "" "" "" "299.4" "306.8" "282.7" "256.6" "278.0" "331.4" "295.2" "224.5" "305.6" "1446.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7397667510889778360" "False" "High" "IsMasterProtein" "Q9H4X1" "Regulator of cell cycle RGCC OS=Homo sapiens OX=9606 GN=RGCC PE=1 SV=1" "0.000" "False" "26.382" "23" "2" "3" "2" "137" "14.6" "4.75" "16.10" "2" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15151" "28984" "ENSG00000102760" "RGCC" "hsa:28984; Q6NZ48; Q9H4X1; Q9UL69" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "" "1" "0" "0.963" "1.019" "1.054" "1.147" "1.150" "0.860" "0.906" "0.965" "0.613" "89.3" "86.0" "91.0" "94.1" "102.4" "102.7" "76.8" "80.9" "86.2" "54.7" "" "" "" "" "" "" "" "" "" "" "79.2" "71.2" "79.4" "70.4" "85.4" "94.4" "64.9" "66.9" "79.0" "54.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3531343313582380268" "False" "High" "IsMasterProtein" "P42338" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1" "0.000" "False" "26.359" "6" "7" "7" "5" "1070" "122.7" "7.09" "23.67" "7" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5291" "ENSG00000051382" "PIK3CB" "D3DNF0; hsa:5291; P42338; Q24JU2" "Downstream TCR signaling; Nephrin family interactions; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; VEGFA-VEGFR2 Pathway; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Signaling by CSF1 (M-CSF) in myeloid cells" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Focal adhesion; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "74" "0" "1.030" "0.961" "1.097" "1.018" "0.953" "1.144" "0.994" "0.971" "1.529" "292.4" "301.1" "280.8" "320.6" "297.7" "278.6" "334.4" "290.6" "283.9" "446.9" "" "" "" "" "" "" "" "" "" "" "259.3" "249.4" "245.0" "239.8" "248.3" "255.9" "282.7" "240.2" "260.4" "446.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586542513876721198" "False" "High" "IsMasterProtein" "O43502" "DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1" "0.000" "False" "26.335" "14" "5" "6" "5" "376" "42.2" "6.74" "18.30" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5889" "ENSG00000108384" "RAD51C" "hsa:5889; O43502; O43503; Q3B783" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination" "DNA repair pathways, full network" "12" "0" "1.046" "1.055" "1.031" "1.120" "1.189" "1.077" "1.155" "1.132" "0.787" "492.2" "514.9" "519.4" "507.6" "551.2" "585.5" "530.4" "568.7" "557.3" "387.4" "" "" "" "" "" "" "" "" "" "" "436.5" "426.5" "453.2" "379.6" "459.6" "537.8" "448.2" "470.1" "511.2" "387.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5140965250815444674" "False" "High" "IsMasterProtein" "Q9ULJ6" "Zinc finger MIZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZMIZ1 PE=1 SV=3" "0.000" "False" "26.332" "6" "7" "8" "4" "1067" "115.4" "7.46" "24.36" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02891, Pf18028" "57178" "ENSG00000108175" "ZMIZ1" "hsa:57178; Q5JSH9; Q7Z7E6; Q9ULJ6" "" "Androgen receptor signaling pathway" "1" "3" "1.015" "1.048" "1.076" "1.066" "1.101" "1.001" "1.010" "0.891" "0.600" "705.5" "716.1" "739.7" "759.0" "752.3" "776.5" "706.0" "712.5" "628.9" "423.3" "" "" "" "" "" "" "" "" "" "" "625.7" "593.2" "645.4" "567.6" "627.3" "713.3" "596.7" "589.0" "576.8" "423.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8599582728715422228" "False" "High" "IsMasterProtein" "Q01432" "AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1" "0.000" "False" "26.331" "7" "5" "8" "4" "767" "88.8" "6.98" "27.32" "5" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf19326" "272" "ENSG00000133805" "AMPD3" "A0AUX0; B7Z2S2; B7Z763; B7Z877; hsa:272; Q01432" "Neutrophil degranulation; Purine salvage" "" "2" "0" "1.076" "1.123" "1.090" "1.061" "1.083" "1.219" "1.269" "1.110" "0.730" "269.0" "289.6" "302.2" "293.2" "285.3" "291.3" "327.8" "341.3" "298.6" "196.4" "" "" "" "" "" "" "" "" "" "" "238.6" "239.9" "263.7" "219.3" "237.9" "267.6" "277.0" "282.1" "273.9" "196.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7491273576453503015" "False" "High" "IsMasterProtein" "Q9BYN0" "Sulfiredoxin-1 OS=Homo sapiens OX=9606 GN=SRXN1 PE=1 SV=2" "0.000" "False" "26.330" "44" "5" "6" "5" "137" "14.3" "8.19" "23.82" "5" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "" "140809" "ENSG00000271303" "SRXN1" "B2R543; hsa:140809; Q8NDM3; Q96AK6; Q9BYN0" "NFE2L2 regulating anti-oxidant/detoxification enzymes" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "4" "0" "1.047" "1.024" "0.991" "1.079" "1.062" "1.065" "1.092" "1.026" "1.107" "416.4" "435.8" "426.5" "412.8" "449.2" "442.1" "443.3" "454.8" "427.4" "460.7" "" "" "" "" "" "" "" "" "" "" "369.2" "361.0" "372.1" "308.7" "374.6" "406.1" "374.6" "375.9" "392.0" "460.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9221829543246918026" "False" "High" "IsMasterProtein" "P23763" "Vesicle-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=VAMP1 PE=1 SV=1" "0.000" "False" "26.326" "28" "2" "4" "2" "118" "12.9" "6.65" "25.85" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6843" "ENSG00000139190" "VAMP1" "A8MVP3; D3DUR3; hsa:6843; O75468; P23763; Q15857; Q6FG94; Q8IVC9" "Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "" "3" "0" "1.013" "1.005" "1.044" "1.090" "0.933" "0.972" "1.026" "0.912" "0.656" "386.2" "391.4" "388.1" "403.4" "421.1" "360.3" "375.5" "396.3" "352.0" "253.3" "" "" "" "" "" "" "" "" "" "" "342.5" "324.2" "338.7" "301.7" "351.1" "331.0" "317.3" "327.6" "322.9" "253.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-989694424414112882" "False" "High" "IsMasterProtein" "Q6P2P2" "Protein arginine N-methyltransferase 9 OS=Homo sapiens OX=9606 GN=PRMT9 PE=1 SV=1" "0.000" "False" "26.318" "8" "6" "7" "6" "845" "94.4" "5.25" "23.12" "6" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf06325" "90826" "ENSG00000164169" "PRMT9" "A8KA39; B3KU92; hsa:90826; Q6P2P2; Q6ZR58; Q8N383; Q9BT55; Q9NT98" "" "" "0" "0" "1.002" "0.795" "0.977" "0.703" "0.707" "0.679" "0.757" "0.748" "1.164" "238.6" "239.1" "189.6" "233.2" "167.8" "168.7" "162.0" "180.6" "178.5" "277.8" "" "" "" "" "" "" "" "" "" "" "211.6" "198.0" "165.5" "174.4" "139.9" "155.0" "136.9" "149.2" "163.7" "277.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124649354194379211" "False" "High" "IsMasterProtein" "Q9P2B7" "Cilia- and flagella-associated protein 97 OS=Homo sapiens OX=9606 GN=CFAP97 PE=1 SV=2" "0.000" "False" "26.289" "12" "6" "6" "6" "532" "59.4" "9.06" "22.07" "6" "other biological processes" "" "" "Pf13879" "57587" "ENSG00000164323" "CFAP97" "B3KRP7; D3DP60; hsa:57587; Q05CU1; Q4W5M4; Q8N6E7; Q9P2B7; Q9UF45" "" "" "0" "0" "1.052" "1.023" "1.026" "0.995" "0.974" "1.002" "0.966" "1.039" "1.337" "834.7" "878.3" "853.9" "856.0" "830.8" "813.3" "836.0" "805.9" "867.2" "1115.6" "" "" "" "" "" "" "" "" "" "" "740.2" "727.5" "745.1" "640.2" "692.8" "747.1" "706.5" "666.2" "795.4" "1115.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8652321965736247269" "False" "High" "IsMasterProtein" "Q8TCA0" "Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1" "0.000" "False" "26.271" "34" "5" "5" "5" "184" "20.5" "6.55" "21.58" "5" "" "" "" "Pf13855" "55222" "ENSG00000172731" "LRRC20" "hsa:55222; Q5T6D4; Q5T6D6; Q8TCA0; Q9NVA6; Q9NVG3" "" "" "0" "0" "0.964" "0.965" "1.049" "0.973" "0.999" "1.072" "1.027" "0.880" "0.496" "504.4" "486.3" "486.8" "529.3" "491.0" "503.8" "540.5" "518.1" "443.8" "250.4" "" "" "" "" "" "" "" "" "" "" "447.3" "402.9" "424.7" "395.8" "409.4" "462.8" "456.8" "428.2" "407.1" "250.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.000" "False" "26.260" "33" "5" "8" "5" "151" "16.6" "7.65" "34.42" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "Neutrophil degranulation; LDL clearance" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "7" "0" "0.912" "0.986" "0.947" "0.984" "1.006" "0.992" "1.044" "0.995" "0.475" "1294.8" "1180.4" "1276.9" "1226.2" "1274.3" "1303.0" "1284.2" "1351.3" "1287.7" "615.2" "" "" "" "" "" "" "" "" "" "" "1148.2" "977.8" "1114.1" "917.0" "1062.6" "1197.0" "1085.4" "1117.0" "1181.0" "615.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8351496581142553779" "False" "High" "IsMasterProtein" "Q12986" "Transcriptional repressor NF-X1 OS=Homo sapiens OX=9606 GN=NFX1 PE=1 SV=2" "0.000" "False" "26.243" "7" "7" "9" "7" "1120" "124.3" "8.24" "30.80" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01422, Pf01424" "4799" "ENSG00000086102" "NFX1" "A8K6H8; hsa:4799; Q12986; Q5VXW6; Q96EL5; Q9BXI1" "" "Fas ligand pathway and stress induction of heat shock proteins" "1" "0" "1.055" "0.973" "1.077" "0.956" "1.022" "0.959" "0.882" "1.012" "0.800" "299.4" "315.9" "291.3" "322.4" "286.3" "306.1" "287.1" "264.1" "302.9" "239.5" "" "" "" "" "" "" "" "" "" "" "265.5" "261.7" "254.2" "241.1" "238.8" "281.2" "242.6" "218.3" "277.8" "239.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1675638052339020088" "False" "High" "IsMasterProtein" "O75146" "Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2" "0.000" "False" "26.236" "6" "7" "7" "7" "1068" "119.3" "6.67" "24.09" "7" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "9026" "ENSG00000130787" "HIP1R" "A6NHQ6; hsa:9026; O75146; Q6NXG8; Q9UED9" "Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "5q35 copy number variation" "3" "0" "0.989" "0.823" "0.869" "0.819" "0.747" "0.973" "0.778" "0.880" "2.182" "182.2" "180.2" "149.9" "158.3" "149.3" "136.0" "177.3" "141.7" "160.2" "397.5" "" "" "" "" "" "" "" "" "" "" "161.5" "149.3" "130.8" "118.4" "124.5" "124.9" "149.9" "117.1" "147.0" "397.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.000" "False" "26.234" "36" "5" "9" "5" "152" "17.0" "8.95" "30.36" "5" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "0.997" "0.971" "0.997" "0.955" "1.011" "0.997" "0.933" "0.980" "0.624" "772.6" "770.4" "750.4" "770.0" "737.8" "780.8" "770.5" "720.5" "756.8" "482.2" "" "" "" "" "" "" "" "" "" "" "685.2" "638.2" "654.7" "575.9" "615.3" "717.3" "651.2" "595.6" "694.1" "482.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2382558777454412534" "False" "High" "IsMasterProtein" "P25686" "DnaJ homolog subfamily B member 2 OS=Homo sapiens OX=9606 GN=DNAJB2 PE=1 SV=3" "0.000" "False" "26.178" "17" "6" "8" "5" "324" "35.6" "5.95" "29.41" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00226" "3300" "ENSG00000135924" "DNAJB2" "A8K9P6; hsa:3300; P25686; Q53QD7; Q8IUK1; Q8IUK2; Q96F52" "" "" "0" "0" "1.028" "0.980" "1.069" "0.993" "0.928" "1.039" "0.954" "0.868" "1.543" "692.0" "711.6" "678.3" "740.0" "687.0" "642.4" "719.0" "659.9" "600.7" "1067.7" "" "" "" "" "" "" "" "" "" "" "613.6" "589.5" "591.8" "553.4" "572.9" "590.1" "607.7" "545.5" "550.9" "1067.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "26.172" "11" "9" "11" "9" "744" "82.5" "6.95" "28.16" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "9" "0" "1.062" "1.074" "0.969" "1.040" "1.002" "0.994" "0.990" "1.074" "1.729" "596.6" "633.7" "640.6" "578.2" "620.2" "597.5" "593.1" "590.4" "641.0" "1031.5" "" "" "" "" "" "" "" "" "" "" "529.0" "524.9" "559.0" "432.4" "517.1" "548.9" "501.3" "488.0" "587.8" "1031.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1796554414882976290" "False" "High" "IsMasterProtein" "Q8TCG1" "Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2" "0.000" "False" "26.161" "8" "8" "9" "8" "905" "102.1" "6.23" "26.09" "8" "cell organization and biogenesis;stress response" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf21044" "57650" "ENSG00000163507" "CIP2A" "A1L4J7; B9EGC3; hsa:57650; Q6P4G6; Q8TCG1; Q8WVP8; Q96PI2; Q9H9C6; Q9P204" "" "Netrin-UNC5B signaling pathway" "1" "0" "0.908" "0.882" "0.978" "0.921" "0.938" "1.011" "0.417" "1.025" "10.127" "484.1" "439.3" "427.0" "473.4" "445.8" "454.0" "489.5" "202.1" "496.2" "4902.1" "" "" "" "" "" "" "" "" "" "" "429.3" "363.9" "372.5" "354.1" "371.7" "417.0" "413.7" "167.0" "455.1" "4902.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "26.146" "33" "7" "8" "7" "208" "24.5" "6.80" "25.09" "7" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "0.983" "0.946" "1.018" "0.905" "0.949" "1.055" "0.901" "0.937" "3.772" "830.6" "816.1" "785.8" "845.3" "752.0" "787.9" "876.4" "748.7" "778.4" "3133.3" "" "" "" "" "" "" "" "" "" "" "736.5" "676.0" "685.7" "632.2" "627.1" "723.8" "740.7" "618.9" "713.9" "3133.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400072782813286453" "False" "High" "IsMasterProtein" "P62424" "Large ribosomal subunit protein eL8 OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "0.000" "False" "26.120" "23" "6" "7" "6" "266" "30.0" "10.61" "22.61" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.084" "1.030" "1.139" "1.118" "1.059" "1.136" "1.158" "1.171" "0.764" "723.3" "784.0" "744.9" "823.8" "808.4" "766.2" "821.8" "837.9" "847.0" "552.7" "" "" "" "" "" "" "" "" "" "" "641.4" "649.4" "650.0" "616.1" "674.1" "703.9" "694.5" "692.6" "776.8" "552.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174880606405183757" "False" "High" "IsMasterProtein" "P56545" "C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1" "0.000" "False" "26.061" "11" "6" "12" "1" "445" "48.9" "6.95" "35.44" "6" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1488" "ENSG00000175029" "CTBP2" "A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8" "Repression of WNT target genes; Signaling by TCF7L2 mutants" "Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157020147431294409" "False" "High" "IsMasterProtein" "P17028" "Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4" "0.000" "False" "26.040" "18" "7" "7" "7" "368" "42.1" "6.21" "26.32" "7" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7572" "ENSG00000172466" "ZNF24" "hsa:7572; O14754; P17028; Q53YE4; Q6ICR5; Q8IZN4" "" "" "0" "0" "0.976" "0.929" "0.931" "0.893" "0.987" "0.841" "0.950" "1.068" "1.097" "595.9" "581.6" "553.9" "554.7" "532.2" "588.4" "501.2" "566.2" "636.5" "653.4" "" "" "" "" "" "" "" "" "" "" "528.4" "481.8" "483.3" "414.8" "443.8" "540.5" "423.6" "468.0" "583.8" "653.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1530625692360911706" "False" "High" "IsMasterProtein" "Q8IWB7" "WD repeat and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDFY1 PE=1 SV=1" "0.000" "False" "26.034" "14" "5" "5" "5" "410" "46.3" "7.33" "18.85" "5" "other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf01363" "57590" "ENSG00000085449" "WDFY1" "hsa:57590; Q53S17; Q8IWB7; Q9H9D5; Q9P2B3" "" "" "0" "0" "1.052" "0.983" "1.032" "1.070" "0.993" "0.974" "0.950" "0.995" "0.538" "753.0" "791.7" "740.2" "776.8" "805.9" "747.4" "733.4" "715.2" "749.2" "405.3" "" "" "" "" "" "" "" "" "" "" "667.7" "655.8" "645.9" "580.9" "672.0" "686.6" "619.9" "591.2" "687.1" "405.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7103280702382610433" "False" "High" "IsMasterProtein" "Q8IX90" "Spindle and kinetochore-associated protein 3 OS=Homo sapiens OX=9606 GN=SKA3 PE=1 SV=2" "0.000" "False" "26.033" "12" "4" "4" "4" "412" "46.3" "5.11" "16.22" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "221150" "ENSG00000165480" "SKA3" "A2A330; A2A331; B2RBY2; hsa:221150; Q5VZV5; Q86WR2; Q8IX90; Q8NBG1; Q96D22" "" "" "0" "0" "1.072" "1.086" "1.184" "1.028" "1.000" "1.159" "0.901" "1.143" "3.604" "245.8" "263.4" "266.9" "291.0" "252.7" "245.7" "284.8" "221.3" "281.0" "885.8" "" "" "" "" "" "" "" "" "" "" "217.9" "218.2" "232.9" "217.6" "210.7" "225.7" "240.7" "183.0" "257.7" "885.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "26.020" "11" "5" "8" "5" "411" "46.6" "4.88" "25.88" "5" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "6" "0" "0.947" "0.862" "0.974" "0.865" "0.899" "0.880" "0.599" "0.910" "5.294" "688.4" "651.8" "593.4" "670.6" "595.6" "618.9" "605.6" "412.1" "626.2" "3644.3" "" "" "" "" "" "" "" "" "" "" "610.5" "539.9" "517.8" "501.5" "496.6" "568.5" "511.8" "340.6" "574.3" "3644.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "High" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.000" "False" "26.005" "25" "4" "8" "3" "150" "16.8" "6.79" "28.23" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "9" "0" "0.969" "1.028" "0.989" "0.960" "1.058" "0.940" "1.011" "0.975" "0.461" "640.8" "620.7" "658.7" "634.1" "615.3" "677.9" "602.5" "647.8" "624.8" "295.6" "" "" "" "" "" "" "" "" "" "" "568.3" "514.2" "574.7" "474.2" "513.1" "622.7" "509.2" "535.4" "573.0" "295.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2730791661393038830" "False" "High" "IsMasterProtein" "Q9Y3P8" "Signaling threshold-regulating transmembrane adapter 1 OS=Homo sapiens OX=9606 GN=SIT1 PE=1 SV=1" "0.000" "False" "25.991" "33" "4" "4" "4" "196" "21.1" "6.30" "19.28" "4" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "" "27240" "ENSG00000137078" "SIT1" "B2RBP9; hsa:27240; Q9Y3P8" "" "" "0" "0" "1.037" "0.986" "1.031" "1.048" "0.967" "0.933" "0.834" "0.967" "0.583" "229.1" "237.6" "226.0" "236.3" "240.2" "221.7" "213.9" "191.2" "221.5" "133.6" "" "" "" "" "" "" "" "" "" "" "203.2" "196.8" "197.2" "176.7" "200.3" "203.6" "180.8" "158.1" "203.2" "133.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "25.985" "6" "6" "7" "6" "1026" "117.3" "5.55" "23.38" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "1.030" "1.026" "0.968" "1.019" "1.125" "0.855" "0.728" "1.001" "3.832" "805.0" "829.4" "826.3" "779.7" "820.3" "905.4" "688.5" "586.3" "806.2" "3084.6" "" "" "" "" "" "" "" "" "" "" "713.9" "687.0" "721.0" "583.1" "684.0" "831.7" "581.9" "484.6" "739.4" "3084.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945611468628581935" "False" "High" "IsMasterProtein" "Q96I25" "Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1" "0.000" "False" "25.975" "15" "7" "7" "7" "401" "44.9" "5.97" "24.56" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf01585" "84991" "ENSG00000134453" "RBM17" "hsa:84991; Q96GY6; Q96I25" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.903" "0.991" "1.188" "1.117" "1.230" "1.031" "1.105" "0.944" "2.075" "39.8" "36.0" "39.4" "47.3" "44.5" "49.0" "41.0" "44.0" "37.6" "82.6" "" "" "" "" "" "" "" "" "" "" "35.3" "29.8" "34.4" "35.4" "37.1" "45.0" "34.7" "36.4" "34.5" "82.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "25.879" "26" "4" "5" "4" "208" "22.5" "7.20" "20.79" "4" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "Peroxisomal protein import" "" "1" "0" "0.977" "1.051" "1.006" "1.008" "1.030" "0.986" "1.003" "0.987" "0.483" "821.9" "802.6" "864.2" "827.2" "828.2" "846.9" "810.3" "824.7" "811.3" "397.2" "" "" "" "" "" "" "" "" "" "" "728.9" "664.9" "754.0" "618.6" "690.6" "778.0" "684.9" "681.7" "744.0" "397.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334840059881177708" "False" "High" "IsMasterProtein" "Q16864" "V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2" "0.000" "False" "25.854" "32" "4" "10" "4" "119" "13.4" "5.52" "36.47" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity" "Pf01990" "9296" "ENSG00000128524" "ATP6V1F" "C9J2K4; hsa:9296; Q16864; Q6IBA8" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.033" "1.004" "1.029" "1.005" "1.069" "1.035" "1.054" "1.050" "0.572" "1297.4" "1340.2" "1302.9" "1335.5" "1303.4" "1387.5" "1342.5" "1367.8" "1362.6" "742.1" "" "" "" "" "" "" "" "" "" "" "1150.5" "1110.2" "1136.8" "998.7" "1086.9" "1274.6" "1134.7" "1130.6" "1249.7" "742.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7619751379045493323" "False" "High" "IsMasterProtein" "P04062" "Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA1 PE=1 SV=3" "0.000" "False" "25.853" "11" "5" "7" "5" "536" "59.7" "7.61" "23.85" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf02055, Pf17189" "2629" "ENSG00000177628" "GBA1" "A8K796; B7Z5G2; B7Z6S1; hsa:2629; J3KQG4; J3KQK9; P04062; Q16545; Q4VX22; Q6I9R6; Q9UMJ8" "Association of TriC/CCT with target proteins during biosynthesis; Glycosphingolipid catabolism" "Sphingolipid pathway" "3" "0" "1.025" "0.983" "0.996" "1.118" "1.033" "0.996" "1.031" "0.905" "0.784" "271.5" "278.3" "266.8" "270.5" "303.7" "280.6" "270.3" "280.0" "245.8" "212.8" "" "" "" "" "" "" "" "" "" "" "240.8" "230.5" "232.8" "202.3" "253.2" "257.7" "228.5" "231.5" "225.4" "212.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308881138529098641" "False" "High" "IsMasterProtein" "Q9Y244" "Proteasome maturation protein OS=Homo sapiens OX=9606 GN=POMP PE=1 SV=1" "0.000" "False" "25.835" "37" "4" "5" "4" "141" "15.8" "5.11" "20.11" "4" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf05348" "51371" "ENSG00000132963" "POMP" "A5HKJ2; D6MXU3; hsa:51371; Q9HB69; Q9Y244" "" "" "0" "0" "1.041" "0.978" "1.066" "1.012" "0.984" "1.074" "1.060" "1.065" "0.703" "354.9" "369.5" "347.1" "378.3" "359.1" "349.3" "381.2" "376.1" "378.1" "249.6" "" "" "" "" "" "" "" "" "" "" "314.8" "306.1" "302.8" "282.9" "299.5" "320.8" "322.2" "310.9" "346.7" "249.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682819818401791106" "False" "High" "IsMasterProtein" "Q9NZJ0" "Denticleless protein homolog OS=Homo sapiens OX=9606 GN=DTL PE=1 SV=3" "0.000" "False" "25.827" "12" "9" "11" "9" "730" "79.4" "8.87" "29.45" "9" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "51514" "ENSG00000143476" "DTL" "A8K8H8; D3DT98; hsa:51514; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; Q9NZJ0" "Neddylation; Recognition of DNA damage by PCNA-containing replication complex" "" "2" "0" "1.058" "0.954" "0.933" "1.013" "0.918" "1.222" "1.225" "1.350" "1.480" "884.3" "935.4" "843.7" "825.0" "896.0" "811.7" "1080.5" "1083.2" "1194.1" "1309.2" "" "" "" "" "" "" "" "" "" "" "784.2" "774.9" "736.2" "617.0" "747.1" "745.6" "913.2" "895.3" "1095.1" "1309.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "25.815" "16" "4" "5" "4" "296" "33.5" "8.44" "20.21" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "Macrophage markers" "3" "0" "1.232" "1.169" "1.196" "1.610" "1.047" "1.140" "1.046" "1.137" "0.560" "281.5" "346.9" "329.2" "336.8" "453.2" "294.8" "320.8" "294.3" "319.9" "157.7" "" "" "" "" "" "" "" "" "" "" "249.6" "287.3" "287.2" "251.9" "377.9" "270.8" "271.2" "243.3" "293.4" "157.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291846979308804894" "False" "High" "IsMasterProtein" "O95182" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFA7 PE=1 SV=3" "0.000" "False" "25.810" "53" "6" "9" "6" "113" "12.5" "10.18" "25.18" "6" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "transporter activity;other molecular function" "Pf07347" "4701" "ENSG00000267855" "NDUFA7" "hsa:4701; O95182" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.950" "1.018" "0.913" "0.948" "1.094" "0.988" "1.105" "1.028" "0.270" "514.5" "488.9" "523.8" "469.9" "487.6" "562.6" "508.1" "568.4" "529.0" "139.1" "" "" "" "" "" "" "" "" "" "" "456.3" "405.0" "457.0" "351.4" "406.6" "516.8" "429.4" "469.9" "485.2" "139.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829507115951982075" "False" "High" "IsMasterProtein" "P19387" "DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2" "0.000" "False" "25.805" "20" "5" "9" "5" "275" "31.4" "4.92" "31.06" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "5432" "ENSG00000102978" "POLR2C" "hsa:5432; O15161; P19387" "RNA polymerase II transcribes snRNA genes; TP53 Regulates Transcription of DNA Repair Genes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Primary ovarian insufficiency" "44" "0" "1.040" "0.961" "1.100" "1.042" "0.965" "0.935" "0.931" "0.920" "1.386" "783.2" "814.7" "752.8" "861.3" "815.9" "755.7" "732.0" "729.3" "720.8" "1085.1" "" "" "" "" "" "" "" "" "" "" "694.5" "674.9" "656.9" "644.2" "680.4" "694.2" "618.7" "602.8" "661.1" "1085.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1711766393091945325" "False" "High" "IsMasterProtein" "Q6DKK2" "Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4" "0.000" "False" "25.788" "14" "5" "5" "5" "380" "42.4" "5.77" "19.20" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;cytoskeleton;mitochondrion;other cell component" "" "Pf13374, Pf13424" "54902" "ENSG00000011295" "TTC19" "A8MZ52; B3KP62; B4DN65; hsa:54902; Q2M248; Q6DKK2; Q7L3U8; Q9H6G3; Q9NXB2" "" "Mitochondrial complex III assembly" "1" "0" "1.099" "1.017" "1.078" "1.136" "1.058" "1.110" "1.112" "1.126" "0.861" "551.8" "606.5" "561.3" "594.9" "626.9" "583.7" "612.6" "613.8" "621.6" "474.9" "" "" "" "" "" "" "" "" "" "" "489.3" "502.4" "489.8" "444.9" "522.8" "536.2" "517.7" "507.4" "570.1" "474.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "107248944887719922" "False" "High" "IsMasterProtein" "Q6VN20" "Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1" "0.000" "False" "25.770" "7" "3" "3" "2" "620" "67.2" "6.77" "14.37" "3" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf00622, Pf08513, Pf10607" "57610" "ENSG00000141084" "RANBP10" "A4FTY2; B4DID0; B4DQH9; E7EW27; hsa:57610; Q6VN20; Q9P264" "MET activates RAS signaling" "Ciliary landscape" "2" "0" "0.992" "0.945" "0.941" "0.994" "0.988" "0.965" "0.838" "0.735" "1.605" "152.6" "151.3" "144.2" "143.6" "151.7" "150.8" "147.3" "127.9" "112.2" "244.9" "" "" "" "" "" "" "" "" "" "" "135.3" "125.4" "125.8" "107.4" "126.5" "138.5" "124.5" "105.7" "102.9" "244.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "High" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.000" "False" "25.752" "4" "7" "7" "7" "1792" "201.4" "9.64" "22.00" "7" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "Antigen processing: Ubiquitination & Proteasome degradation; RHOBTB1 GTPase cycle" "" "2" "0" "0.987" "0.909" "0.932" "0.815" "0.778" "0.872" "0.887" "0.909" "0.782" "205.5" "202.7" "186.9" "191.5" "167.5" "159.9" "179.1" "182.2" "186.7" "160.6" "" "" "" "" "" "" "" "" "" "" "182.2" "167.9" "163.0" "143.2" "139.7" "146.8" "151.4" "150.6" "171.2" "160.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.000" "False" "25.750" "21" "3" "7" "3" "190" "20.7" "6.32" "34.91" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "1.041" "1.025" "1.112" "1.157" "1.028" "1.148" "1.102" "0.996" "0.726" "533.0" "554.7" "546.2" "592.5" "616.9" "548.1" "611.7" "587.1" "530.6" "387.1" "" "" "" "" "" "" "" "" "" "" "472.6" "459.5" "476.6" "443.1" "514.4" "503.5" "517.0" "485.3" "486.7" "387.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4213076317646871579" "False" "High" "IsMasterProtein" "P16219" "Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADS PE=1 SV=1" "0.000" "False" "25.693" "14" "5" "5" "5" "412" "44.3" "7.99" "18.99" "5" "other metabolic processes" "cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "35" "ENSG00000122971" "ACADS" "hsa:35; P16219; P78331" "Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "6" "0" "1.071" "0.991" "1.084" "1.080" "1.075" "1.040" "1.045" "1.010" "0.828" "884.9" "948.0" "876.9" "959.2" "955.6" "950.9" "920.1" "925.0" "893.4" "732.6" "" "" "" "" "" "" "" "" "" "" "784.7" "785.3" "765.1" "717.4" "796.9" "873.5" "777.7" "764.6" "819.4" "732.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357357949464127480" "False" "High" "IsMasterProtein" "O75503" "Bis(monoacylglycero)phosphate synthase CLN5 OS=Homo sapiens OX=9606 GN=CLN5 PE=1 SV=2" "0.000" "False" "25.647" "19" "6" "9" "6" "358" "41.5" "7.40" "36.93" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15014" "1203" "ENSG00000102805" "CLN5" "B3KQK7; hsa:1203; O75503" "" "" "0" "0" "1.073" "1.049" "1.009" "1.041" "1.064" "1.185" "1.101" "1.098" "0.674" "490.5" "526.3" "514.6" "494.9" "510.5" "521.7" "581.1" "540.1" "538.5" "330.7" "" "" "" "" "" "" "" "" "" "" "435.0" "436.0" "449.0" "370.1" "425.7" "479.3" "491.1" "446.4" "493.8" "330.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2567249118239018231" "False" "High" "IsMasterProtein" "Q9C0B5" "Palmitoyltransferase ZDHHC5 OS=Homo sapiens OX=9606 GN=ZDHHC5 PE=1 SV=2" "0.000" "False" "25.602" "11" "7" "8" "7" "715" "77.5" "9.01" "25.57" "7" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01529" "25921" "ENSG00000156599" "ZDHHC5" "hsa:25921; Q2TGF0; Q6ZMF0; Q8TAK8; Q9C0B5; Q9H923; Q9UFI7" "Maturation of spike protein" "" "1" "0" "0.969" "1.005" "0.848" "0.935" "1.027" "0.895" "0.959" "0.965" "0.831" "1210.9" "1173.6" "1217.4" "1026.9" "1131.9" "1243.4" "1083.5" "1161.0" "1168.3" "1006.7" "" "" "" "" "" "" "" "" "" "" "1073.8" "972.2" "1062.2" "768.0" "943.8" "1142.2" "915.8" "959.6" "1071.5" "1006.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1244063578202926483" "False" "High" "IsMasterProtein" "Q68D10" "Protein SPT2 homolog OS=Homo sapiens OX=9606 GN=SPTY2D1 PE=1 SV=3" "0.000" "False" "25.564" "9" "6" "6" "6" "685" "75.6" "9.79" "22.95" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08243" "144108" "ENSG00000179119" "SPTY2D1" "hsa:144108; Q68D10; Q6AWA5; Q6MZI5; Q7Z390; Q7Z470; Q86VG8; Q8N3E7; Q8N417; Q8N8I3" "" "" "0" "0" "0.893" "0.940" "0.855" "0.831" "0.650" "0.768" "0.829" "0.902" "0.589" "433.4" "387.0" "407.5" "370.5" "360.2" "281.7" "333.0" "359.2" "391.1" "255.1" "" "" "" "" "" "" "" "" "" "" "384.4" "320.6" "355.6" "277.1" "300.4" "258.7" "281.4" "296.9" "358.7" "255.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.000" "False" "25.501" "32" "2" "9" "2" "63" "6.9" "7.24" "34.55" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Mitochondrial protein import" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "5" "0" "0.897" "1.021" "0.905" "0.939" "1.028" "0.962" "0.988" "1.069" "0.431" "1107.4" "993.4" "1130.4" "1001.7" "1039.7" "1138.2" "1065.2" "1093.7" "1183.3" "476.8" "" "" "" "" "" "" "" "" "" "" "982.0" "822.9" "986.3" "749.1" "867.0" "1045.5" "900.3" "904.0" "1085.2" "476.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2027123753413932420" "False" "High" "IsMasterProtein" "Q8NBN7" "Retinol dehydrogenase 13 OS=Homo sapiens OX=9606 GN=RDH13 PE=1 SV=2" "0.000" "False" "25.482" "10" "3" "4" "3" "331" "35.9" "8.10" "15.77" "3" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00106" "112724" "ENSG00000160439; ENSG00000273944; ENSG00000274418; ENSG00000274504; ENSG00000275474; ENSG00000276341; ENSG00000276684; ENSG00000276826; ENSG00000278149; ENSG00000278284" "RDH13" "Q6UX79; Q8NBN7; Q96G88" "RA biosynthesis pathway" "" "1" "0" "0.993" "1.031" "1.015" "1.049" "0.974" "0.978" "1.011" "1.060" "1.054" "382.4" "379.5" "394.1" "388.2" "401.2" "372.6" "374.2" "386.6" "405.2" "403.2" "" "" "" "" "" "" "" "" "" "" "339.1" "314.4" "343.9" "290.3" "334.6" "342.2" "316.2" "319.5" "371.6" "403.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794546056511531982" "False" "High" "IsMasterProtein" "Q969Q5" "Ras-related protein Rab-24 OS=Homo sapiens OX=9606 GN=RAB24 PE=1 SV=1" "0.000" "False" "25.450" "25" "5" "5" "5" "203" "23.1" "6.23" "22.23" "5" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53917" "ENSG00000169228" "RAB24" "A0A024R7N9; hsa:53917; Q7Z4Z7; Q969Q5" "Neutrophil degranulation; RAB geranylgeranylation" "5q35 copy number variation" "3" "0" "0.986" "0.951" "1.044" "0.999" "1.014" "0.991" "0.963" "0.990" "0.871" "985.7" "972.2" "937.6" "1029.0" "984.7" "999.3" "976.7" "949.6" "976.2" "858.5" "" "" "" "" "" "" "" "" "" "" "874.1" "805.3" "818.1" "769.6" "821.1" "918.0" "825.5" "784.9" "895.4" "858.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7346476942521402077" "False" "High" "IsMasterProtein" "Q9BUT9" "MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2" "0.000" "False" "25.424" "29" "3" "4" "3" "160" "17.8" "9.41" "20.34" "3" "" "nucleus;other cell component" "" "Pf14799" "84331" "ENSG00000172366" "MCRIP2" "hsa:84331; Q969E9; Q96KV8; Q9BUT9" "" "" "0" "0" "1.010" "1.004" "1.026" "0.941" "0.972" "0.993" "1.015" "0.911" "0.800" "281.4" "284.2" "282.4" "288.6" "264.8" "273.6" "279.4" "285.6" "256.5" "225.1" "" "" "" "" "" "" "" "" "" "" "249.6" "235.4" "246.4" "215.9" "220.8" "251.3" "236.2" "236.1" "235.2" "225.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766769550040713609" "False" "High" "IsMasterProtein" "Q9UHI6" "Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2" "0.000" "False" "25.403" "7" "6" "6" "6" "824" "92.2" "6.95" "21.27" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11218" "ENSG00000064703" "DDX20" "B4DWV7; hsa:11218; Q96F72; Q9NVM3; Q9UF59; Q9UHI6; Q9UIY0; Q9Y659" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "mRNA processing; Male infertility" "4" "0" "0.924" "0.952" "0.971" "0.908" "0.866" "0.903" "0.489" "0.901" "7.811" "285.3" "263.6" "271.6" "277.0" "259.0" "247.1" "257.5" "139.6" "257.0" "2228.4" "" "" "" "" "" "" "" "" "" "" "253.0" "218.3" "237.0" "207.1" "216.0" "226.9" "217.7" "115.4" "235.7" "2228.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331965257696457103" "False" "High" "IsMasterProtein" "Q9H467" "CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1" "0.000" "False" "25.386" "19" "5" "10" "5" "287" "32.0" "4.81" "30.92" "5" "other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02845" "79004" "ENSG00000107874" "CUEDC2" "D3DR88; hsa:79004; Q9BWG8; Q9H467" "" "" "0" "0" "1.004" "1.017" "1.033" "0.955" "1.039" "0.992" "1.016" "0.946" "0.892" "1065.4" "1069.2" "1083.7" "1101.0" "1017.2" "1107.3" "1056.6" "1082.7" "1008.2" "950.4" "" "" "" "" "" "" "" "" "" "" "944.8" "885.7" "945.6" "823.4" "848.2" "1017.2" "893.0" "895.0" "924.7" "950.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2679816748943853066" "False" "High" "IsMasterProtein" "Q9ULH7" "Myocardin-related transcription factor B OS=Homo sapiens OX=9606 GN=MRTFB PE=1 SV=3" "0.000" "False" "25.355" "9" "8" "10" "8" "1088" "118.1" "6.28" "31.50" "8" "other biological processes" "nucleus" "other molecular function" "Pf02037, Pf02755" "57496" "ENSG00000186260" "MRTFB" "A6ND53; B4DGT8; hsa:57496; Q68CT1; Q6UB16; Q86WW2; Q8N226; Q9ULH7" "" "" "0" "0" "1.068" "1.068" "0.980" "1.000" "1.140" "1.128" "1.079" "1.231" "0.786" "543.0" "579.7" "580.0" "532.1" "542.8" "619.2" "612.6" "585.7" "668.6" "426.9" "" "" "" "" "" "" "" "" "" "" "481.5" "480.2" "506.1" "398.0" "452.6" "568.8" "517.8" "484.1" "613.2" "426.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "173468840260374204" "False" "High" "IsMasterProtein" "Q86WB0" "Zinc finger C3HC-type protein 1 OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1" "0.000" "False" "25.327" "11" "4" "4" "4" "502" "55.2" "5.62" "16.83" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf07967, Pf08600" "51530" "ENSG00000091732" "ZC3HC1" "A6NH66; hsa:51530; Q75MF3; Q75MF4; Q86WB0; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0" "Nuclear events stimulated by ALK signaling in cancer" "" "1" "0" "0.926" "0.979" "0.940" "0.984" "0.965" "0.952" "0.706" "0.949" "5.021" "222.3" "205.8" "217.6" "209.1" "218.8" "214.5" "211.6" "156.9" "211.1" "1116.2" "" "" "" "" "" "" "" "" "" "" "197.1" "170.5" "189.9" "156.4" "182.5" "197.0" "178.8" "129.6" "193.6" "1116.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "25.326" "37" "5" "11" "5" "125" "13.7" "10.11" "36.85" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.118" "1.074" "1.077" "1.116" "0.987" "1.029" "0.997" "1.027" "0.899" "1382.0" "1545.6" "1484.0" "1488.8" "1542.2" "1364.6" "1422.4" "1378.1" "1419.8" "1242.4" "" "" "" "" "" "" "" "" "" "" "1225.5" "1280.3" "1294.9" "1113.4" "1286.0" "1253.5" "1202.2" "1139.1" "1302.2" "1242.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6975409787188746590" "False" "High" "IsMasterProtein" "Q7L513" "Fc receptor-like A OS=Homo sapiens OX=9606 GN=FCRLA PE=1 SV=2" "0.000" "False" "25.290" "15" "4" "4" "4" "359" "38.9" "5.36" "18.14" "4" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13895" "84824" "ENSG00000132185" "FCRLA" "A0N0M1; A6NC03; A6NL20; F5H720; F8W743; G3V1J2; hsa:84824; Q5VXA1; Q5VXA2; Q5VXA3; Q5VXA4; Q5VXB0; Q5VXB1; Q7L513; Q8NEW4; Q8WXH3; Q96PC6; Q96PJ0; Q96PJ1; Q96PJ2; Q96PJ4; Q9BR57" "" "" "0" "0" "1.152" "1.161" "1.064" "1.154" "1.156" "1.147" "1.112" "1.130" "1.149" "699.0" "804.9" "811.7" "744.0" "806.7" "808.1" "802.0" "777.4" "790.0" "803.4" "" "" "" "" "" "" "" "" "" "" "619.8" "666.8" "708.3" "556.4" "672.7" "742.3" "677.8" "642.6" "724.5" "803.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6470269132294442760" "False" "High" "IsMasterProtein" "Q8WUM0" "Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2" "0.000" "False" "25.259" "6" "7" "7" "7" "1156" "128.9" "5.10" "24.47" "7" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03177" "55746" "ENSG00000069248" "NUP133" "B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4" "ISG15 antiviral mechanism; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; tRNA processing in the nucleus; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "Ciliary landscape" "36" "0" "1.033" "0.974" "1.117" "1.053" "0.940" "1.266" "1.139" "1.245" "4.200" "818.2" "845.4" "796.8" "913.8" "861.6" "768.8" "1036.2" "932.0" "1018.3" "3436.5" "" "" "" "" "" "" "" "" "" "" "725.5" "700.3" "695.3" "683.4" "718.5" "706.2" "875.7" "770.4" "933.9" "3436.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6289756953830423632" "False" "High" "IsMasterProtein" "Q8WV99" "AN1-type zinc finger protein 2B OS=Homo sapiens OX=9606 GN=ZFAND2B PE=1 SV=1" "0.000" "False" "25.226" "21" "5" "7" "5" "257" "28.0" "6.92" "23.93" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01428, Pf02809" "130617" "ENSG00000158552" "ZFAND2B" "hsa:130617; Q8NB98; Q8WV99" "" "" "0" "0" "1.018" "1.007" "0.999" "1.104" "0.939" "1.044" "1.083" "1.110" "0.483" "143.6" "146.2" "144.6" "143.5" "158.5" "134.9" "149.9" "155.6" "159.4" "69.3" "" "" "" "" "" "" "" "" "" "" "127.4" "121.1" "126.2" "107.3" "132.2" "123.9" "126.7" "128.6" "146.1" "69.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4646306898255403066" "False" "High" "IsMasterProtein" "Q96FF9" "Sororin OS=Homo sapiens OX=9606 GN=CDCA5 PE=1 SV=1" "0.000" "False" "25.186" "23" "5" "7" "5" "252" "27.6" "9.61" "25.03" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09666" "113130" "ENSG00000146670" "CDCA5" "A8K625; hsa:113130; Q96FF9" "Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Establishment of Sister Chromatid Cohesion" "" "3" "0" "1.056" "1.011" "1.038" "1.001" "1.088" "1.100" "1.027" "1.004" "1.300" "281.4" "297.3" "284.5" "292.1" "281.7" "306.3" "309.5" "289.1" "282.6" "366.0" "" "" "" "" "" "" "" "" "" "" "249.6" "246.2" "248.2" "218.5" "234.9" "281.4" "261.6" "238.9" "259.2" "366.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229408047793123568" "False" "High" "IsMasterProtein" "O75155" "Cullin-associated NEDD8-dissociated protein 2 OS=Homo sapiens OX=9606 GN=CAND2 PE=1 SV=3" "0.000" "False" "25.181" "2" "2" "5" "1" "1236" "135.2" "5.68" "19.72" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08623" "23066" "ENSG00000144712" "CAND2" "B9EGM9; E9KL24; hsa:23066; O75155" "" "" "0" "0" "1.022" "0.865" "1.131" "0.862" "1.080" "1.029" "1.069" "0.884" "0.470" "350.5" "358.3" "303.1" "396.5" "302.0" "378.6" "360.6" "374.7" "310.0" "164.6" "" "" "" "" "" "" "" "" "" "" "310.8" "296.8" "264.5" "296.5" "251.8" "347.8" "304.8" "309.7" "284.3" "164.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4095542091731415933" "False" "High" "IsMasterProtein" "Q9HA47" "Uridine-cytidine kinase 1 OS=Homo sapiens OX=9606 GN=UCK1 PE=1 SV=1" "0.000" "False" "25.148" "26" "6" "8" "5" "277" "31.4" "7.30" "29.42" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "83549" "ENSG00000130717" "UCK1" "hsa:83549; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0; Q9HA47" "Pyrimidine salvage" "Fluoropyrimidine activity; Pyrimidine metabolism; IL-18 signaling pathway" "4" "0" "0.988" "0.919" "0.975" "0.916" "0.975" "1.013" "1.071" "1.014" "0.623" "880.4" "870.3" "809.2" "858.7" "806.6" "858.4" "891.6" "942.8" "893.0" "548.7" "" "" "" "" "" "" "" "" "" "" "780.8" "720.9" "706.0" "642.2" "672.6" "788.6" "753.6" "779.3" "819.0" "548.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "462176972851051990" "False" "High" "IsMasterProtein" "Q05513" "Protein kinase C zeta type OS=Homo sapiens OX=9606 GN=PRKCZ PE=1 SV=4" "0.000" "False" "25.144" "9" "6" "8" "3" "592" "67.6" "5.77" "28.20" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5590" "ENSG00000067606" "PRKCZ" "A8K4N0; A8MU64; B7Z2J7; E9PCW2; hsa:5590; Q05513; Q15207; Q5SYT5; Q969S4" "GPVI-mediated activation cascade; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); RHO GTPases Activate NADPH Oxidases" "Type II diabetes mellitus; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Myometrial relaxation and contraction pathways; G protein signaling pathways; Interleukin-1 induced activation of NF-kB; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Prader-Willi and Angelman syndrome; Splicing factor NOVA regulated synaptic proteins; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; 1p36 copy number variation syndrome; Calcium regulation in cardiac cells; HDAC6 interactions in the central nervous system" "31" "0" "1.042" "1.023" "1.141" "1.105" "1.163" "1.079" "1.162" "1.053" "0.795" "361.6" "376.8" "370.1" "412.7" "399.5" "420.6" "390.3" "420.1" "380.8" "287.4" "" "" "" "" "" "" "" "" "" "" "320.7" "312.1" "323.0" "308.6" "333.1" "386.3" "329.9" "347.3" "349.3" "287.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "High" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.000" "False" "25.104" "30" "5" "6" "4" "228" "24.8" "9.63" "23.65" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "" "2" "1" "0.892" "0.910" "1.018" "0.957" "0.962" "0.958" "1.005" "0.930" "0.615" "428.5" "382.4" "389.8" "436.4" "410.0" "412.1" "410.3" "430.7" "398.3" "263.3" "" "" "" "" "" "" "" "" "" "" "380.0" "316.8" "340.1" "326.4" "341.9" "378.6" "346.8" "356.0" "365.3" "263.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7222165964987125403" "False" "High" "IsMasterProtein" "P36954" "DNA-directed RNA polymerase II subunit RPB9 OS=Homo sapiens OX=9606 GN=POLR2I PE=1 SV=1" "0.000" "False" "25.092" "34" "4" "7" "4" "125" "14.5" "5.14" "20.92" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "5438" "ENSG00000105258" "POLR2I" "B2R5J2; hsa:5438; P36954; Q6NW05" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.090" "1.013" "0.953" "0.967" "1.158" "0.896" "1.006" "1.031" "0.650" "761.9" "830.7" "771.9" "726.3" "736.8" "882.3" "682.9" "766.3" "785.9" "495.2" "" "" "" "" "" "" "" "" "" "" "675.7" "688.1" "673.5" "543.2" "614.4" "810.5" "577.1" "633.4" "720.8" "495.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "High" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.000" "False" "25.067" "19" "3" "5" "3" "159" "17.7" "11.66" "20.04" "3" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.887" "0.871" "0.832" "0.752" "0.687" "0.758" "0.920" "0.958" "0.423" "863.3" "766.2" "752.4" "718.1" "649.0" "593.5" "654.2" "793.9" "827.1" "364.9" "" "" "" "" "" "" "" "" "" "" "765.6" "634.7" "656.5" "537.0" "541.2" "545.2" "552.9" "656.2" "758.5" "364.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1371524125527115551" "False" "High" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "0.000" "False" "25.039" "4" "8" "9" "8" "1697" "193.3" "8.12" "28.07" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "" "3" "0" "1.214" "0.855" "0.871" "0.861" "0.876" "0.951" "0.605" "0.900" "6.287" "183.6" "223.0" "157.0" "160.0" "158.2" "160.8" "174.6" "111.0" "165.2" "1154.5" "" "" "" "" "" "" "" "" "" "" "162.8" "184.7" "136.9" "119.6" "131.9" "147.7" "147.6" "91.8" "151.5" "1154.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1716870644817082742" "False" "High" "IsMasterProtein" "Q15751" "Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2" "0.000" "False" "25.034" "1" "7" "7" "7" "4861" "531.9" "6.04" "20.49" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00415, Pf00622, Pf00632" "8925" "ENSG00000103657" "HERC1" "hsa:8925; Q15751; Q8IW65" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.944" "0.879" "0.940" "0.844" "0.794" "0.951" "0.807" "0.904" "2.050" "359.5" "339.5" "316.2" "338.1" "303.6" "285.3" "342.1" "290.1" "325.0" "737.1" "" "" "" "" "" "" "" "" "" "" "318.8" "281.2" "275.9" "252.9" "253.1" "262.1" "289.1" "239.8" "298.0" "737.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "High" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.000" "False" "25.020" "7" "4" "5" "4" "1025" "117.3" "5.73" "23.97" "4" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "" "3" "0" "1.065" "1.018" "1.091" "1.027" "1.075" "1.074" "0.940" "1.025" "0.858" "460.0" "489.8" "468.3" "502.0" "472.2" "494.6" "494.1" "432.2" "471.5" "394.9" "" "" "" "" "" "" "" "" "" "" "407.9" "405.7" "408.6" "375.5" "393.7" "454.4" "417.6" "357.3" "432.4" "394.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "High" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.000" "False" "24.999" "6" "6" "7" "6" "1186" "131.6" "7.20" "20.41" "6" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "1.006" "0.974" "0.988" "0.910" "0.877" "0.944" "0.762" "0.901" "2.731" "434.3" "436.8" "422.8" "429.0" "395.4" "380.8" "410.1" "331.1" "391.3" "1186.2" "" "" "" "" "" "" "" "" "" "" "385.1" "361.8" "368.9" "320.9" "329.7" "349.8" "346.6" "273.6" "358.8" "1186.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2877167820272688386" "False" "High" "IsMasterProtein" "Q9Y3S1" "Serine/threonine-protein kinase WNK2 OS=Homo sapiens OX=9606 GN=WNK2 PE=1 SV=4" "0.000" "False" "24.984" "2" "6" "9" "1" "2297" "242.5" "6.13" "22.99" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "65268" "ENSG00000165238" "WNK2" "hsa:65268; Q5VWF1; Q5VWF2; Q8IY36; Q9C0A3; Q9H3P4; Q9Y3S1" "Stimuli-sensing channels" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3862869163996360692" "False" "High" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "0.000" "False" "24.977" "27" "7" "10" "7" "199" "22.1" "8.10" "30.20" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "0.976" "1.001" "0.929" "0.944" "0.991" "1.024" "0.963" "0.951" "0.805" "1218.7" "1189.8" "1220.0" "1132.1" "1150.2" "1207.9" "1247.4" "1173.1" "1159.4" "980.7" "" "" "" "" "" "" "" "" "" "" "1080.7" "985.6" "1064.5" "846.6" "959.1" "1109.5" "1054.3" "969.7" "1063.3" "980.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965973480370309944" "False" "High" "IsMasterProtein" "Q53HC9" "EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2" "0.000" "False" "24.954" "15" "5" "6" "5" "387" "43.6" "5.06" "23.62" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "" "Pf00400" "7260" "ENSG00000032389" "EIPR1" "D6W4Y1; hsa:7260; O43179; Q53HC9; Q53S19; Q53SG2" "" "Ciliary landscape" "1" "0" "1.067" "1.012" "1.105" "1.053" "1.103" "0.982" "0.996" "0.959" "0.748" "1052.2" "1122.8" "1064.8" "1162.9" "1108.1" "1160.3" "1033.1" "1047.8" "1008.6" "787.3" "" "" "" "" "" "" "" "" "" "" "933.0" "930.1" "929.1" "869.7" "924.0" "1065.9" "873.2" "866.1" "925.0" "787.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697554350722155722" "False" "High" "IsMasterProtein" "Q96B45" "BLOC-1-related complex subunit 7 OS=Homo sapiens OX=9606 GN=BORCS7 PE=1 SV=2" "0.000" "False" "24.949" "54" "4" "4" "4" "106" "11.7" "6.79" "18.42" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf16088" "119032" "ENSG00000166275" "BORCS7" "B2R488; B3KUW4; C9K0X3; hsa:119032; Q96B45" "" "" "0" "0" "1.038" "0.892" "1.114" "1.053" "0.972" "1.029" "0.974" "0.951" "0.633" "176.8" "183.4" "157.6" "197.0" "186.2" "171.8" "181.9" "172.1" "168.1" "111.9" "" "" "" "" "" "" "" "" "" "" "156.7" "151.9" "137.5" "147.3" "155.2" "157.8" "153.7" "142.3" "154.2" "111.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "High" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.000" "False" "24.948" "11" "6" "6" "6" "562" "62.6" "8.21" "21.84" "6" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Synthesis of PIPs at the plasma membrane" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "4" "0" "0.824" "0.823" "0.821" "0.862" "0.942" "0.857" "0.889" "0.858" "0.946" "494.1" "407.0" "406.6" "405.6" "425.7" "465.5" "423.7" "439.5" "423.7" "467.2" "" "" "" "" "" "" "" "" "" "" "438.2" "337.1" "354.7" "303.4" "355.0" "427.6" "358.1" "363.3" "388.6" "467.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080105971862608535" "False" "High" "IsMasterProtein" "Q9BYJ9" "YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1" "0.000" "False" "24.902" "9" "5" "7" "1" "559" "60.8" "8.79" "26.93" "5" "cell organization and biogenesis;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "54915" "ENSG00000149658" "YTHDF1" "hsa:54915; Q8N3G5; Q8TBT1; Q96AN4; Q96S57; Q9BTI7; Q9BYJ9; Q9NX79" "" "" "0" "0" "0.901" "0.855" "0.890" "0.815" "0.886" "0.725" "0.608" "0.850" "3.241" "109.5" "98.7" "93.7" "97.4" "89.3" "97.0" "79.4" "66.6" "93.2" "355.0" "" "" "" "" "" "" "" "" "" "" "97.1" "81.7" "81.8" "72.9" "74.4" "89.1" "67.1" "55.0" "85.4" "355.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3258131120717726760" "False" "High" "IsMasterProtein" "Q96EU6" "Ribosomal RNA processing protein 36 homolog OS=Homo sapiens OX=9606 GN=RRP36 PE=1 SV=1" "0.000" "False" "24.902" "24" "5" "6" "5" "259" "29.8" "10.17" "19.55" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06102" "88745" "ENSG00000124541" "RRP36" "hsa:88745; Q96EU6; Q9BRF6; Q9P0C8" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.980" "0.956" "0.918" "0.930" "0.916" "0.660" "0.700" "0.774" "0.374" "553.0" "542.1" "528.8" "507.8" "514.2" "506.4" "364.8" "386.9" "428.1" "206.7" "" "" "" "" "" "" "" "" "" "" "490.4" "449.0" "461.4" "379.8" "428.8" "465.2" "308.3" "319.8" "392.6" "206.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "24.896" "65" "4" "19" "4" "92" "10.8" "9.44" "60.59" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "mRNA Splicing - Major Pathway; snRNP Assembly; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.103" "1.056" "1.194" "1.123" "1.071" "1.130" "1.050" "0.976" "0.731" "905.2" "998.1" "956.0" "1080.9" "1016.3" "969.2" "1023.2" "950.3" "883.6" "661.4" "" "" "" "" "" "" "" "" "" "" "802.7" "826.8" "834.1" "808.4" "847.5" "890.3" "864.7" "785.5" "810.4" "661.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-268059577032989138" "False" "High" "IsMasterProtein" "Q9NVJ2" "ADP-ribosylation factor-like protein 8B OS=Homo sapiens OX=9606 GN=ARL8B PE=1 SV=1" "0.000" "False" "24.832" "26" "6" "9" "2" "186" "21.5" "8.43" "31.56" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "55207" "ENSG00000134108" "ARL8B" "B4DI85; hsa:55207; Q9NVJ2" "" "Ciliary landscape" "1" "0" "0.934" "0.970" "1.048" "1.185" "1.085" "1.005" "1.110" "1.077" "0.895" "144.0" "134.5" "139.7" "150.8" "170.6" "156.2" "144.6" "159.8" "155.1" "128.8" "" "" "" "" "" "" "" "" "" "" "127.7" "111.4" "121.9" "112.8" "142.3" "143.5" "122.2" "132.1" "142.2" "128.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1411281452547832793" "False" "High" "IsMasterProtein" "Q9UPT9" "Ubiquitin carboxyl-terminal hydrolase 22 OS=Homo sapiens OX=9606 GN=USP22 PE=1 SV=2" "0.000" "False" "24.813" "13" "7" "8" "7" "525" "59.9" "8.05" "23.57" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00443, Pf02148" "23326" "ENSG00000124422" "USP22" "A0JNS3; hsa:23326; Q2NLE2; Q6MZY4; Q8TBS8; Q96IW5; Q9UPT9" "Ub-specific processing proteases; HATs acetylate histones" "" "2" "0" "0.989" "1.084" "1.033" "1.060" "1.024" "1.150" "1.124" "1.346" "3.191" "368.2" "364.2" "399.1" "380.3" "390.4" "377.1" "423.4" "413.9" "495.6" "1175.0" "" "" "" "" "" "" "" "" "" "" "326.5" "301.7" "348.3" "284.4" "325.5" "346.4" "357.8" "342.1" "454.6" "1175.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355239685975103350" "False" "High" "IsMasterProtein" "O14578" "Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2" "0.000" "False" "24.804" "5" "10" "10" "10" "2027" "231.3" "6.57" "31.08" "10" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433, Pf00780" "11113" "ENSG00000122966" "CIT" "hsa:11113; O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate CIT" "Pleural mesothelioma; G13 signaling pathway" "7" "0" "0.964" "0.962" "0.942" "0.819" "0.880" "0.841" "0.850" "0.968" "1.603" "346.0" "333.4" "332.8" "326.1" "283.5" "304.4" "291.1" "294.0" "334.9" "554.5" "" "" "" "" "" "" "" "" "" "" "306.8" "276.2" "290.4" "243.9" "236.4" "279.6" "246.0" "243.0" "307.2" "554.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "24.679" "3" "5" "5" "5" "2319" "243.8" "6.90" "17.33" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "0.891" "0.797" "0.812" "0.796" "0.797" "0.777" "0.760" "0.831" "1.011" "776.6" "692.2" "618.7" "630.4" "617.9" "618.8" "603.7" "590.0" "645.6" "784.8" "" "" "" "" "" "" "" "" "" "" "688.6" "573.4" "539.9" "471.5" "515.3" "568.4" "510.2" "487.7" "592.1" "784.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "24.676" "21" "4" "7" "4" "178" "20.2" "9.60" "28.57" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "15" "0" "1.017" "0.964" "1.016" "0.994" "1.016" "0.857" "0.737" "0.796" "1.260" "465.6" "473.7" "448.7" "473.2" "462.6" "473.2" "398.8" "343.3" "370.6" "586.7" "" "" "" "" "" "" "" "" "" "" "412.9" "392.4" "391.5" "353.9" "385.7" "434.7" "337.1" "283.7" "339.9" "586.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3820767575237366491" "False" "High" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "0.000" "False" "24.657" "5" "5" "5" "5" "1272" "147.7" "5.69" "18.86" "5" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "2" "0" "0.974" "1.001" "1.076" "0.914" "0.780" "0.995" "0.667" "1.018" "6.360" "184.6" "179.9" "184.8" "198.7" "168.8" "144.0" "183.6" "123.2" "187.9" "1174.3" "" "" "" "" "" "" "" "" "" "" "163.7" "149.0" "161.2" "148.6" "140.8" "132.3" "155.2" "101.8" "172.4" "1174.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "24.648" "31" "3" "18" "3" "59" "6.9" "10.45" "58.95" "3" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "0.913" "0.952" "0.939" "0.929" "0.955" "0.927" "0.908" "0.908" "0.500" "3199.6" "2921.0" "3047.6" "3003.6" "2971.7" "3055.2" "2965.8" "2906.6" "2904.6" "1600.4" "" "" "" "" "" "" "" "" "" "" "2837.3" "2419.6" "2659.2" "2246.3" "2478.0" "2806.5" "2506.6" "2402.5" "2663.9" "1600.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3761626498643372027" "False" "High" "IsMasterProtein" "P05362" "Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2" "0.000" "False" "24.552" "11" "5" "6" "5" "532" "57.8" "7.99" "22.68" "5" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf03921, Pf13895, Pf21146" "3383" "ENSG00000090339" "ICAM1" "B2R6M3; hsa:3383; P05362; Q5NKV7; Q96B50" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling; miRNA role in immune response in sepsis; Platelet-mediated interactions with vascular and circulating cells; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Urotensin-II-mediated signaling pathway; Role of ROS in COVID-19 endothelial dysfunction; IL-26 signaling pathways; Type II interferon signaling" "27" "0" "1.002" "0.897" "1.120" "0.939" "0.837" "0.933" "0.946" "1.090" "0.600" "359.7" "360.4" "322.6" "402.9" "338.0" "301.0" "335.5" "340.2" "392.3" "216.0" "" "" "" "" "" "" "" "" "" "" "319.0" "298.5" "281.5" "301.3" "281.8" "276.5" "283.6" "281.2" "359.8" "216.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "24.537" "55" "5" "14" "5" "80" "9.1" "9.58" "40.43" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "0.937" "1.028" "0.914" "0.933" "1.059" "0.972" "1.024" "1.038" "0.422" "1822.6" "1708.6" "1873.7" "1666.4" "1701.1" "1930.3" "1772.5" "1866.8" "1892.0" "769.8" "" "" "" "" "" "" "" "" "" "" "1616.3" "1415.3" "1634.9" "1246.3" "1418.5" "1773.2" "1498.0" "1543.1" "1735.2" "769.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2631004439744677845" "False" "High" "IsMasterProtein" "P04637" "Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4" "0.000" "False" "24.524" "16" "6" "9" "6" "393" "43.6" "6.79" "29.87" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00870, Pf07710, Pf08563, Pf18521" "7157" "ENSG00000141510" "TP53" "hsa:7157; P04637; Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98; Q3LRW1; Q3LRW2; Q3LRW3; Q3LRW4; Q3LRW5; Q86UG1; Q8J016; Q99659; Q9BTM4; Q9HAQ8; Q9NP68; Q9NPJ2; Q9NZD0; Q9UBI2; Q9UQ61" "Ub-specific processing proteases; PKR-mediated signaling; Zygotic genome activation (ZGA); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Autodegradation of the E3 ubiquitin ligase COP1; The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-4 and Interleukin-13 signaling; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Factors involved in megakaryocyte development and platelet production; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; Regulation of NF-kappa B signaling; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional activation of cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of prostate cancer signaling pathways; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Hereditary leiomyomatosis and renal cell carcinoma pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in progeria; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Pleural mesothelioma; Lipid metabolism in senescent cells; DYRK1A involvement regarding cell proliferation in brain development; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma; 11p11.2 copy number variation syndrome ; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "116" "0" "1.224" "1.085" "1.286" "1.126" "1.105" "1.263" "0.824" "0.920" "5.104" "128.3" "157.1" "139.3" "165.0" "144.5" "141.8" "162.1" "105.8" "118.1" "655.0" "" "" "" "" "" "" "" "" "" "" "113.8" "130.2" "121.5" "123.4" "120.5" "130.2" "137.0" "87.4" "108.3" "655.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7197122219504261731" "False" "High" "IsMasterProtein" "Q96EK9" "Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1" "0.000" "False" "24.472" "15" "3" "4" "3" "354" "38.6" "6.95" "15.07" "3" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf08433" "112970" "ENSG00000198841" "KTI12" "hsa:112970; Q96EK9" "" "" "0" "0" "0.941" "0.848" "0.964" "0.998" "0.829" "0.959" "0.871" "1.045" "2.966" "387.0" "364.1" "328.1" "373.0" "386.1" "320.9" "371.3" "337.2" "404.4" "1147.7" "" "" "" "" "" "" "" "" "" "" "343.2" "301.6" "286.3" "278.9" "321.9" "294.7" "313.8" "278.7" "370.9" "1147.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2600353075121762102" "False" "High" "IsMasterProtein" "A4D161" "Protein FAM221A OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1" "0.000" "False" "24.457" "22" "5" "6" "5" "298" "33.1" "6.74" "23.73" "5" "" "" "" "Pf14753" "340277" "ENSG00000188732" "FAM221A" "A4D161; hsa:340277; Q05CG4; Q4G0Q7; Q6P519" "" "" "0" "0" "1.086" "0.978" "0.963" "1.024" "1.044" "0.955" "0.949" "1.037" "0.910" "257.0" "279.0" "251.5" "247.6" "263.3" "268.2" "245.6" "243.9" "266.5" "233.9" "" "" "" "" "" "" "" "" "" "" "227.9" "231.1" "219.4" "185.2" "219.5" "246.4" "207.5" "201.6" "244.4" "233.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.000" "False" "24.395" "14" "3" "4" "3" "270" "31.3" "7.47" "18.67" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "5" "0" "1.042" "1.086" "1.107" "1.065" "0.945" "1.272" "1.240" "1.365" "1.634" "176.0" "183.4" "191.2" "194.8" "187.5" "166.3" "223.8" "218.2" "240.3" "287.6" "" "" "" "" "" "" "" "" "" "" "156.1" "151.9" "166.8" "145.7" "156.4" "152.7" "189.1" "180.3" "220.4" "287.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "472644769200762840" "False" "High" "IsMasterProtein" "Q9UJK0" "18S rRNA aminocarboxypropyltransferase OS=Homo sapiens OX=9606 GN=TSR3 PE=1 SV=1" "0.000" "False" "24.377" "23" "5" "6" "5" "312" "33.6" "6.87" "24.01" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf04034, Pf04068" "115939" "ENSG00000007520" "TSR3" "hsa:115939; Q6PJT8; Q9UJK0" "rRNA modification in the nucleus and cytosol" "" "1" "0" "1.022" "1.025" "1.086" "1.057" "1.114" "1.038" "1.094" "1.066" "0.890" "322.6" "329.8" "330.6" "350.4" "340.9" "359.5" "334.9" "353.0" "344.0" "287.1" "" "" "" "" "" "" "" "" "" "" "286.1" "273.2" "288.5" "262.0" "284.3" "330.2" "283.1" "291.8" "315.5" "287.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4094952149974440381" "False" "High" "IsMasterProtein" "Q9H3P2" "Negative elongation factor A OS=Homo sapiens OX=9606 GN=NELFA PE=1 SV=3" "0.000" "False" "24.329" "10" "4" "4" "4" "528" "57.2" "9.03" "16.01" "4" "other biological processes" "cytosol;nucleus" "other molecular function" "" "7469" "ENSG00000185049" "NELFA" "A2A2T1; hsa:7469; O95392; Q9H3P2" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "16" "0" "1.194" "0.981" "1.130" "1.043" "1.015" "1.032" "0.705" "0.918" "7.361" "169.7" "202.6" "166.4" "191.8" "176.9" "172.1" "175.1" "119.7" "155.7" "1248.8" "" "" "" "" "" "" "" "" "" "" "150.4" "167.8" "145.2" "143.4" "147.5" "158.1" "147.9" "98.9" "142.8" "1248.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2135832377467312061" "False" "High" "IsMasterProtein" "Q9UHC7" "E3 ubiquitin-protein ligase makorin-1 OS=Homo sapiens OX=9606 GN=MKRN1 PE=1 SV=3" "0.000" "False" "24.305" "11" "5" "8" "5" "482" "53.3" "5.14" "28.73" "5" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00097, Pf14608, Pf15815, Pf18044" "23608" "ENSG00000133606" "MKRN1" "A4D1T7; B3KXB4; Q256Y7; Q59G11; Q6GSF1; Q9H0G0; Q9UEZ7; Q9UHC7; Q9UHW2" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; AKT phosphorylates targets in the cytosol" "" "3" "0" "0.947" "0.853" "0.794" "0.749" "0.784" "0.606" "0.613" "0.696" "0.735" "413.8" "392.0" "352.8" "328.4" "309.8" "324.5" "250.7" "253.7" "288.0" "304.3" "" "" "" "" "" "" "" "" "" "" "366.9" "324.7" "307.8" "245.6" "258.3" "298.0" "211.9" "209.7" "264.1" "304.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6622895814543661851" "False" "High" "IsMasterProtein" "O15504" "Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1" "0.000" "False" "24.295" "13" "4" "6" "4" "423" "44.8" "9.19" "20.13" "4" "transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf18044" "11097" "ENSG00000136243" "NUP42" "A4D143; B4DP42; hsa:11097; O15504; Q49AE7; Q9BS49" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "1.043" "1.016" "1.039" "1.060" "0.986" "1.041" "1.039" "1.099" "0.805" "493.6" "514.8" "501.5" "513.0" "523.3" "486.5" "514.0" "512.8" "542.6" "397.5" "" "" "" "" "" "" "" "" "" "" "437.7" "426.4" "437.6" "383.6" "436.4" "446.9" "434.5" "423.9" "497.6" "397.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "24.275" "20" "4" "9" "4" "176" "19.4" "4.75" "33.49" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "0.976" "0.975" "0.983" "0.965" "0.995" "1.026" "1.012" "1.006" "0.488" "1160.2" "1132.2" "1131.0" "1140.8" "1119.2" "1153.9" "1190.1" "1174.1" "1167.6" "566.6" "" "" "" "" "" "" "" "" "" "" "1028.9" "937.8" "986.8" "853.1" "933.2" "1059.9" "1005.8" "970.5" "1070.9" "566.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "24.272" "30" "6" "9" "6" "184" "21.4" "5.11" "28.17" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "4" "0" "1.002" "1.021" "0.966" "1.037" "1.083" "1.010" "1.038" "0.962" "0.688" "1077.5" "1079.7" "1100.3" "1041.0" "1117.8" "1166.4" "1087.9" "1118.0" "1036.6" "740.9" "" "" "" "" "" "" "" "" "" "" "955.5" "894.3" "960.1" "778.5" "932.1" "1071.5" "919.4" "924.1" "950.7" "740.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1100964520603987926" "False" "High" "IsMasterProtein" "Q13825" "Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1" "0.000" "False" "24.238" "15" "4" "4" "4" "339" "35.6" "9.48" "15.79" "4" "other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00378" "549" "ENSG00000148090" "AUH" "B1ALV7; B1ALV8; hsa:549; Q13825; Q8WUE4" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "1.059" "0.992" "1.093" "1.013" "1.018" "0.989" "1.006" "1.016" "1.259" "384.5" "407.0" "381.6" "420.3" "389.6" "391.3" "380.2" "386.8" "390.7" "484.0" "" "" "" "" "" "" "" "" "" "" "341.0" "337.2" "332.9" "314.3" "324.8" "359.5" "321.3" "319.7" "358.4" "484.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1614464300928510251" "False" "High" "IsMasterProtein" "P55854" "Small ubiquitin-related modifier 3 OS=Homo sapiens OX=9606 GN=SUMO3 PE=1 SV=2" "0.000" "False" "24.227" "27" "4" "15" "1" "103" "11.6" "5.49" "52.20" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11976" "6612" "ENSG00000184900" "SUMO3" "B2R5X4; B4DUW4; hsa:6612; P55854; Q53HI9; Q6FGD4; Q9BWR4" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "Exercise-induced circadian regulation" "12" "3" "0.955" "0.945" "0.934" "0.871" "0.851" "0.777" "0.790" "0.783" "0.633" "3996.3" "3817.8" "3778.1" "3732.9" "3480.5" "3401.2" "3106.5" "3155.9" "3129.9" "2530.3" "" "" "" "" "" "" "" "" "" "" "3543.9" "3162.5" "3296.5" "2791.7" "2902.3" "3124.4" "2625.5" "2608.6" "2870.6" "2530.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227436002470218796" "False" "High" "IsMasterProtein" "P05141" "ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7" "0.000" "False" "24.196" "19" "6" "6" "6" "298" "32.8" "9.69" "19.07" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "transporter activity;other molecular function" "Pf00153" "292" "ENSG00000005022" "SLC25A5" "B2RCV1; hsa:292; O43350; P05141" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Mitochondrial protein degradation; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease" "6" "0" "1.098" "0.784" "1.029" "1.017" "1.064" "0.941" "0.784" "1.169" "0.482" "370.0" "406.4" "289.9" "380.6" "376.5" "393.8" "348.2" "290.1" "432.6" "178.3" "" "" "" "" "" "" "" "" "" "" "328.1" "336.6" "253.0" "284.7" "313.9" "361.7" "294.3" "239.8" "396.8" "178.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1536948539302412641" "False" "High" "IsMasterProtein" "O60927" "E3 ubiquitin-protein ligase PPP1R11 OS=Homo sapiens OX=9606 GN=PPP1R11 PE=1 SV=1" "0.000" "False" "24.177" "13" "2" "4" "2" "126" "13.9" "7.01" "17.37" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07491" "6992" "ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829" "PPP1R11" "hsa:6992; O60927" "" "" "0" "0" "0.889" "0.895" "0.884" "0.942" "0.817" "0.906" "0.938" "1.051" "0.676" "276.5" "245.7" "247.4" "244.5" "260.4" "225.9" "250.4" "259.3" "290.7" "187.0" "" "" "" "" "" "" "" "" "" "" "245.2" "203.5" "215.8" "182.9" "217.1" "207.5" "211.6" "214.3" "266.6" "187.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8993746763041335004" "False" "High" "IsMasterProtein" "Q69YQ0" "Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=3" "0.000" "False" "24.130" "5" "6" "7" "5" "1117" "124.5" "5.76" "26.53" "6" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00307" "23384" "ENSG00000100014" "SPECC1L" "B7Z758; F5H1H6; hsa:23384; O15081; Q69YQ0" "" "" "0" "0" "1.135" "0.996" "0.973" "1.037" "1.047" "0.968" "0.792" "0.957" "2.386" "498.2" "565.5" "496.5" "484.9" "516.6" "521.8" "482.1" "394.4" "476.8" "1188.7" "" "" "" "" "" "" "" "" "" "" "441.8" "468.4" "433.2" "362.6" "430.8" "479.3" "407.4" "326.0" "437.3" "1188.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "High" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.000" "False" "24.088" "16" "4" "5" "4" "332" "37.5" "8.40" "17.55" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.023" "0.920" "1.221" "1.002" "0.998" "1.110" "0.923" "1.011" "2.235" "318.8" "326.2" "293.4" "389.3" "319.4" "318.2" "353.9" "294.2" "322.2" "712.4" "" "" "" "" "" "" "" "" "" "" "282.7" "270.2" "256.0" "291.1" "266.3" "292.3" "299.1" "243.2" "295.5" "712.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "24.050" "9" "6" "6" "2" "598" "64.3" "7.56" "18.77" "6" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "Coenzyme A biosynthesis" "" "1" "0" "1.050" "0.977" "1.136" "1.000" "1.002" "1.142" "1.148" "1.121" "0.684" "381.3" "400.6" "372.4" "433.0" "381.4" "382.0" "435.5" "437.8" "427.4" "260.9" "" "" "" "" "" "" "" "" "" "" "338.2" "331.8" "325.0" "323.9" "318.0" "350.9" "368.1" "361.9" "392.0" "260.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6036892115816411697" "False" "High" "IsMasterProtein" "Q9H9G7" "Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2" "0.000" "False" "24.044" "7" "5" "5" "1" "860" "97.3" "9.11" "19.75" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "192669" "ENSG00000126070" "AGO3" "B1ALI0; hsa:192669; Q5TA55; Q9H1U6; Q9H9G7" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1040458896990308382" "False" "High" "IsMasterProtein" "Q9Y5J7" "Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1" "0.000" "False" "24.022" "39" "3" "5" "3" "89" "10.4" "7.21" "22.29" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26520" "ENSG00000100575" "TIMM9" "B2R584; hsa:26520; Q9Y5J7" "Mitochondrial protein import; Mitochondrial protein degradation" "" "2" "0" "0.919" "1.066" "0.898" "1.017" "1.127" "0.934" "1.044" "1.020" "0.203" "1260.8" "1159.3" "1343.5" "1131.8" "1281.6" "1420.8" "1177.4" "1315.8" "1286.0" "256.1" "" "" "" "" "" "" "" "" "" "" "1118.0" "960.3" "1172.2" "846.5" "1068.7" "1305.1" "995.1" "1087.6" "1179.4" "256.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5097662091813912850" "False" "High" "IsMasterProtein" "Q02252" "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2" "0.000" "False" "23.995" "9" "4" "6" "4" "535" "57.8" "8.50" "20.07" "4" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf00171" "4329" "ENSG00000119711" "ALDH6A1" "B2R609; B4DFS8; hsa:4329; J3KNU8; Q02252; Q9UKM8" "Branched-chain amino acid catabolism" "" "1" "0" "1.164" "1.059" "1.143" "1.244" "1.251" "1.375" "1.274" "1.398" "3.054" "350.3" "407.8" "370.9" "400.5" "435.8" "438.3" "481.7" "446.3" "489.6" "1069.7" "" "" "" "" "" "" "" "" "" "" "310.6" "337.8" "323.7" "299.5" "363.4" "402.6" "407.1" "368.9" "449.0" "1069.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "High" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.000" "False" "23.987" "5" "5" "6" "5" "1076" "122.9" "6.35" "23.36" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "0.884" "0.800" "0.998" "0.855" "0.751" "0.815" "0.603" "0.796" "3.839" "452.6" "399.9" "362.1" "451.5" "387.1" "339.7" "368.7" "273.1" "360.3" "1737.6" "" "" "" "" "" "" "" "" "" "" "401.3" "331.3" "315.9" "337.7" "322.8" "312.0" "311.6" "225.7" "330.5" "1737.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "High" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.000" "False" "23.970" "14" "6" "6" "6" "438" "48.1" "7.84" "20.79" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "Synthesis of diphthamide-EEF2" "" "1" "0" "0.937" "0.941" "0.814" "0.782" "0.757" "0.764" "0.919" "1.132" "0.772" "457.0" "428.1" "429.9" "372.1" "357.5" "345.8" "348.9" "419.8" "517.4" "352.9" "" "" "" "" "" "" "" "" "" "" "405.2" "354.6" "375.1" "278.3" "298.1" "317.6" "294.9" "347.0" "474.5" "352.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "23.967" "29" "4" "6" "4" "103" "12.0" "5.91" "22.89" "4" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "" "Pathways affected in adenoid cystic carcinoma" "1" "0" "0.969" "0.936" "0.907" "0.936" "0.963" "0.846" "0.921" "0.961" "1.569" "869.6" "843.0" "814.3" "788.5" "814.2" "837.5" "735.8" "800.5" "835.6" "1364.6" "" "" "" "" "" "" "" "" "" "" "771.1" "698.3" "710.5" "589.7" "678.9" "769.3" "621.8" "661.7" "766.4" "1364.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "23.964" "10" "4" "6" "4" "393" "44.9" "8.63" "20.92" "4" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "Platelet degranulation" "" "1" "0" "0.968" "0.857" "1.173" "0.939" "0.881" "1.036" "0.858" "0.877" "2.384" "374.5" "362.3" "320.9" "439.4" "351.6" "329.8" "387.9" "321.3" "328.5" "892.8" "" "" "" "" "" "" "" "" "" "" "332.1" "300.1" "280.0" "328.6" "293.2" "303.0" "327.9" "265.6" "301.3" "892.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-143757823348630571" "False" "High" "IsMasterProtein" "Q8IV08" "5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1" "0.000" "False" "23.903" "11" "6" "8" "5" "490" "54.7" "6.47" "22.14" "6" "DNA metabolism;stress response;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf13918" "23646" "ENSG00000105223" "PLD3" "hsa:23646; Q8IV08; Q92853; Q9BW87" "Role of phospholipids in phagocytosis; Synthesis of PG" "" "2" "0" "0.994" "1.028" "1.111" "1.145" "1.081" "1.106" "1.130" "0.974" "0.584" "292.2" "290.4" "300.2" "324.7" "334.6" "315.9" "323.2" "330.2" "284.4" "170.6" "" "" "" "" "" "" "" "" "" "" "259.1" "240.6" "261.9" "242.8" "279.0" "290.2" "273.2" "272.9" "260.9" "170.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "23.901" "32" "6" "24" "1" "136" "15.3" "11.27" "76.99" "6" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Factors involved in megakaryocyte development and platelet production; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Amyloid fiber formation; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "36" "5" "0.616" "0.630" "0.604" "0.644" "0.587" "0.554" "0.574" "0.514" "0.426" "4281.5" "2637.7" "2695.9" "2587.4" "2756.3" "2511.1" "2372.1" "2458.8" "2199.0" "1822.8" "" "" "" "" "" "" "" "" "" "" "3796.7" "2184.9" "2352.3" "1935.0" "2298.4" "2306.8" "2004.8" "2032.3" "2016.8" "1822.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "23.891" "36" "4" "8" "4" "76" "8.5" "8.88" "25.67" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.003" "0.998" "1.144" "1.071" "0.930" "1.097" "1.064" "0.946" "0.614" "590.7" "592.3" "589.7" "676.0" "632.8" "549.3" "648.2" "628.5" "558.8" "362.9" "" "" "" "" "" "" "" "" "" "" "523.9" "490.7" "514.5" "505.6" "527.7" "504.6" "547.8" "519.5" "512.5" "362.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "23.884" "42" "7" "10" "7" "146" "16.4" "10.21" "28.86" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.038" "0.950" "1.092" "0.981" "0.848" "0.934" "0.893" "0.891" "1.843" "506.0" "525.3" "480.7" "552.4" "496.6" "429.3" "472.6" "451.9" "451.1" "932.4" "" "" "" "" "" "" "" "" "" "" "448.7" "435.1" "419.4" "413.1" "414.1" "394.4" "399.4" "373.5" "413.7" "932.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613446227669289232" "False" "High" "IsMasterProtein" "Q9H8K7" "ATPase PAAT OS=Homo sapiens OX=9606 GN=PAAT PE=1 SV=2" "0.000" "False" "23.877" "14" "7" "8" "7" "445" "49.2" "6.25" "24.97" "7" "" "mitochondrion;other cell component" "other molecular function" "Pf14958" "80007" "ENSG00000119965" "PAAT" "hsa:80007; Q0P6C6; Q8N597; Q9H8K7" "" "" "0" "0" "1.012" "0.940" "0.945" "0.948" "0.973" "0.991" "0.939" "0.925" "0.882" "696.8" "705.4" "655.2" "658.5" "660.8" "677.6" "690.8" "654.0" "644.3" "614.9" "" "" "" "" "" "" "" "" "" "" "617.9" "584.3" "571.7" "492.4" "551.0" "622.5" "583.8" "540.6" "590.9" "614.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5230253163633364857" "False" "High" "IsMasterProtein" "Q92834" "X-linked retinitis pigmentosa GTPase regulator OS=Homo sapiens OX=9606 GN=RPGR PE=1 SV=2" "0.000" "False" "23.863" "6" "5" "5" "5" "1020" "113.3" "4.86" "17.56" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00415" "6103" "ENSG00000156313" "RPGR" "B1ARN3; E9PE28; hsa:6103; O00702; O00737; Q3KN84; Q8N5T6; Q92834; Q93039; Q9HD29; Q9UMR1" "" "Ciliary landscape" "1" "0" "1.006" "1.066" "1.079" "1.056" "1.049" "1.081" "1.053" "1.091" "0.822" "340.4" "342.3" "362.9" "367.2" "359.6" "357.2" "368.1" "358.6" "371.3" "279.9" "" "" "" "" "" "" "" "" "" "" "301.9" "283.6" "316.6" "274.6" "299.8" "328.2" "311.1" "296.4" "340.5" "279.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "23.862" "39" "4" "8" "4" "109" "12.3" "10.24" "29.86" "4" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "Mitochondrial RNA degradation" "" "1" "0" "0.927" "0.961" "1.065" "1.026" "1.047" "1.024" "1.010" "1.035" "0.994" "375.9" "348.6" "361.4" "400.5" "385.8" "393.6" "384.9" "379.7" "389.0" "373.8" "" "" "" "" "" "" "" "" "" "" "333.4" "288.8" "315.4" "299.5" "321.7" "361.6" "325.3" "313.8" "356.8" "373.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677605172328813102" "False" "High" "IsMasterProtein" "Q6IAA8" "Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2" "0.000" "False" "23.857" "30" "3" "4" "3" "161" "17.7" "5.15" "16.33" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15454" "55004" "ENSG00000149357" "LAMTOR1" "hsa:55004; Q6IAA8; Q8WZ09; Q9NWT0" "Regulation of PTEN gene transcription; Neutrophil degranulation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; Amino acids regulate mTORC1; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; mTORC1-mediated signalling; RHOH GTPase cycle" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "17" "0" "1.083" "0.880" "0.988" "0.983" "0.737" "0.957" "1.060" "0.882" "0.656" "41.5" "44.9" "36.5" "41.0" "40.8" "30.6" "39.7" "44.0" "36.6" "27.2" "" "" "" "" "" "" "" "" "" "" "36.8" "37.2" "31.8" "30.7" "34.0" "28.1" "33.5" "36.3" "33.6" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "23.804" "31" "4" "9" "2" "128" "13.5" "10.58" "29.62" "4" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "35" "0" "0.940" "0.880" "0.982" "0.944" "0.925" "0.900" "0.869" "0.738" "1.333" "192.4" "180.9" "169.3" "189.0" "181.7" "178.0" "173.3" "167.2" "142.0" "256.6" "" "" "" "" "" "" "" "" "" "" "170.6" "149.9" "147.7" "141.3" "151.5" "163.5" "146.4" "138.2" "130.3" "256.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1875589299266399931" "False" "High" "IsMasterProtein" "Q14139" "Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2" "0.000" "False" "23.801" "4" "3" "4" "3" "1066" "122.5" "5.24" "16.94" "3" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "9354" "ENSG00000110344" "UBE4A" "B0YJB6; Q14139; Q2M1H0; Q6P5T4; Q7Z639" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.072" "1.019" "1.018" "1.036" "1.059" "0.986" "0.438" "0.924" "10.014" "175.8" "188.5" "179.0" "179.0" "182.0" "186.1" "173.4" "77.0" "162.4" "1760.3" "" "" "" "" "" "" "" "" "" "" "155.9" "156.1" "156.2" "133.8" "151.8" "170.9" "146.5" "63.7" "148.9" "1760.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.000" "False" "23.761" "6" "8" "9" "8" "1135" "128.1" "7.83" "25.60" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "1.027" "0.995" "1.054" "0.993" "1.040" "1.382" "1.406" "1.398" "1.228" "935.9" "961.4" "930.9" "986.1" "929.4" "973.2" "1293.1" "1315.7" "1308.4" "1148.9" "" "" "" "" "" "" "" "" "" "" "829.9" "796.4" "812.2" "737.5" "775.0" "894.0" "1092.9" "1087.5" "1200.0" "1148.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "23.666" "3" "6" "7" "6" "2472" "274.3" "5.52" "13.93" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "3" "0" "1.003" "0.922" "0.966" "0.864" "0.818" "0.886" "0.802" "0.920" "2.651" "608.8" "610.4" "561.2" "587.9" "525.8" "497.7" "539.4" "488.2" "560.3" "1613.9" "" "" "" "" "" "" "" "" "" "" "539.9" "505.6" "489.7" "439.7" "438.4" "457.2" "455.8" "403.5" "513.9" "1613.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.000" "False" "23.607" "42" "4" "8" "4" "91" "10.8" "10.73" "30.69" "4" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "2" "0" "0.947" "0.993" "0.903" "0.987" "1.048" "0.985" "1.008" "0.978" "0.443" "736.1" "696.8" "730.7" "664.9" "726.3" "771.3" "724.8" "742.3" "719.8" "326.3" "" "" "" "" "" "" "" "" "" "" "652.8" "577.2" "637.6" "497.3" "605.7" "708.5" "612.6" "613.6" "660.1" "326.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5148486115263509013" "False" "High" "IsMasterProtein" "Q9C0B0" "RING finger protein unkempt homolog OS=Homo sapiens OX=9606 GN=UNK PE=1 SV=2" "0.000" "False" "23.582" "8" "6" "6" "6" "810" "88.0" "6.86" "20.68" "6" "developmental processes;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf18384" "85451" "ENSG00000132478" "UNK" "hsa:85451; Q9C0B0" "" "" "0" "0" "1.015" "0.957" "1.013" "0.965" "1.063" "0.934" "0.906" "0.907" "0.993" "712.6" "723.5" "682.0" "721.8" "687.7" "757.2" "665.3" "645.4" "646.6" "707.4" "" "" "" "" "" "" "" "" "" "" "631.9" "599.3" "595.1" "539.8" "573.5" "695.5" "562.3" "533.5" "593.1" "707.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841941710175491915" "False" "High" "IsMasterProtein" "Q5HYK3" "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ5 PE=1 SV=2" "0.000" "False" "23.569" "17" "5" "6" "5" "327" "37.1" "6.95" "19.33" "5" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01209" "84274" "ENSG00000110871" "COQ5" "B2RDU9; B3GK62; B4DEJ4; hsa:84274; Q32Q28; Q53HH0; Q5HYK3; Q96LV1; Q9BSP8" "Ubiquinol biosynthesis" "" "1" "0" "0.947" "1.073" "1.105" "1.087" "1.011" "0.978" "1.037" "0.929" "0.662" "265.4" "251.2" "284.7" "293.1" "288.5" "268.3" "259.4" "275.3" "246.5" "175.7" "" "" "" "" "" "" "" "" "" "" "235.3" "208.1" "248.4" "219.2" "240.6" "246.4" "219.3" "227.5" "226.1" "175.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6246281522193444266" "False" "High" "IsMasterProtein" "O60573" "Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1" "0.000" "False" "23.564" "26" "5" "5" "5" "245" "28.3" "8.88" "20.39" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "9470" "ENSG00000135930" "EIF4E2" "B8ZZJ9; hsa:9470; O60573; O75349" "ISG15 antiviral mechanism" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance" "4" "0" "0.927" "1.029" "1.005" "0.990" "1.010" "1.196" "1.046" "1.161" "1.630" "201.8" "187.0" "207.6" "202.9" "199.9" "203.9" "241.4" "211.1" "234.4" "329.0" "" "" "" "" "" "" "" "" "" "" "179.0" "154.9" "181.2" "151.7" "166.7" "187.3" "204.1" "174.5" "214.9" "329.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1000021269069197599" "False" "High" "IsMasterProtein" "Q9Y5V3" "Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3" "0.000" "False" "23.545" "10" "6" "6" "5" "778" "86.1" "5.83" "19.26" "6" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01454" "9500" "ENSG00000179222" "MAGED1" "hsa:9500; Q5VSH6; Q8IZ84; Q8WY92; Q9H352; Q9HBT4; Q9UF36; Q9Y5V3" "NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand" "5q35 copy number variation" "3" "0" "1.017" "0.999" "0.961" "0.957" "1.036" "0.966" "1.027" "1.030" "0.977" "404.6" "411.3" "404.3" "388.8" "387.3" "419.2" "390.9" "415.7" "416.6" "395.4" "" "" "" "" "" "" "" "" "" "" "358.8" "340.7" "352.8" "290.8" "322.9" "385.1" "330.3" "343.6" "382.1" "395.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "23.524" "6" "7" "7" "6" "1337" "150.7" "7.91" "23.42" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "0" "1.056" "0.955" "1.062" "0.987" "0.984" "0.937" "0.651" "0.967" "6.586" "180.1" "190.1" "172.0" "191.3" "177.7" "177.2" "168.7" "117.2" "174.1" "1186.1" "" "" "" "" "" "" "" "" "" "" "159.7" "157.5" "150.1" "143.1" "148.2" "162.7" "142.6" "96.9" "159.7" "1186.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9189940377941500292" "False" "High" "IsMasterProtein" "Q9Y3D6" "Mitochondrial fission 1 protein OS=Homo sapiens OX=9606 GN=FIS1 PE=1 SV=2" "0.000" "False" "23.519" "28" "4" "5" "4" "152" "16.9" "8.79" "17.82" "4" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14852, Pf14853" "51024" "ENSG00000214253" "FIS1" "hsa:51024; Q9BTP3; Q9Y3D6" "Class I peroxisomal membrane protein import" "CAMKK2 pathway" "2" "0" "1.021" "1.072" "1.045" "1.040" "0.939" "0.956" "1.062" "1.153" "0.884" "820.4" "837.9" "879.2" "857.2" "852.9" "770.7" "783.9" "871.4" "946.1" "725.4" "" "" "" "" "" "" "" "" "" "" "727.5" "694.1" "767.1" "641.1" "711.2" "707.9" "662.5" "720.3" "867.7" "725.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442712666023189626" "False" "High" "IsMasterProtein" "O43251" "RNA binding protein fox-1 homolog 2 OS=Homo sapiens OX=9606 GN=RBFOX2 PE=1 SV=3" "0.000" "False" "23.517" "9" "3" "6" "3" "390" "41.3" "7.27" "22.25" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12414" "23543" "ENSG00000100320; ENSG00000277564" "RBFOX2" "A4F5G8; A8K5Z5; B0QYY8; B0QYY9; hsa:23543; O43251; Q0PRL5; Q0VH35; Q5TF71; Q6IC09; Q8TD00; Q8WYB1; Q96DZ6; Q96NL7; Q9UGW4; Q9UH33" "FGFR2 alternative splicing" "Mammalian disorder of sexual development" "2" "0" "1.069" "1.059" "1.115" "1.037" "1.019" "1.045" "0.912" "0.983" "1.651" "318.5" "340.6" "337.3" "355.1" "330.4" "324.5" "333.0" "290.5" "313.1" "525.9" "" "" "" "" "" "" "" "" "" "" "282.4" "282.2" "294.3" "265.5" "275.5" "298.1" "281.4" "240.2" "287.1" "525.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6504309841328491303" "False" "High" "IsMasterProtein" "Q8NAF0" "Zinc finger protein 579 OS=Homo sapiens OX=9606 GN=ZNF579 PE=1 SV=2" "0.000" "False" "23.465" "9" "4" "4" "4" "562" "60.5" "8.69" "17.78" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "163033" "ENSG00000218891" "ZNF579" "hsa:163033; Q8NAF0" "" "" "0" "0" "0.972" "0.953" "0.909" "0.964" "0.932" "1.018" "0.966" "0.865" "0.651" "156.9" "152.5" "149.5" "142.7" "151.3" "146.3" "159.8" "151.7" "135.8" "102.1" "" "" "" "" "" "" "" "" "" "" "139.2" "126.3" "130.5" "106.7" "126.2" "134.4" "135.0" "125.4" "124.5" "102.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4782042828393349132" "False" "High" "IsMasterProtein" "P52756" "RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2" "0.000" "False" "23.462" "6" "5" "5" "3" "815" "92.1" "6.28" "19.77" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "10181" "ENSG00000003756" "RBM5" "B2RA45; B4DM16; B4DMF9; B4DZ63; hsa:10181; P52756; Q93021; Q9BU14; Q9HDA6; Q9UKY8; Q9UL24" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.120" "0.969" "1.077" "1.014" "1.021" "0.953" "0.923" "0.978" "2.168" "320.9" "359.4" "311.0" "345.5" "325.4" "327.6" "305.7" "296.1" "314.0" "695.7" "" "" "" "" "" "" "" "" "" "" "284.6" "297.8" "271.3" "258.4" "271.4" "300.9" "258.4" "244.8" "287.9" "695.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1854771477011875853" "False" "High" "IsMasterProtein" "Q14119" "Vascular endothelial zinc finger 1 OS=Homo sapiens OX=9606 GN=VEZF1 PE=1 SV=2" "0.000" "False" "23.458" "9" "5" "13" "3" "521" "56.9" "9.52" "32.76" "5" "stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "7716" "ENSG00000136451" "VEZF1" "hsa:7716; Q14119" "" "" "0" "0" "0.979" "0.917" "0.938" "1.096" "0.914" "0.925" "0.940" "0.893" "1.618" "158.8" "155.5" "145.6" "149.0" "174.1" "145.1" "146.9" "149.3" "141.8" "257.0" "" "" "" "" "" "" "" "" "" "" "140.8" "128.8" "127.1" "111.5" "145.2" "133.3" "124.2" "123.4" "130.0" "257.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3449420204754272229" "False" "High" "IsMasterProtein" "Q9NV56" "MRG/MORF4L-binding protein OS=Homo sapiens OX=9606 GN=MRGBP PE=1 SV=1" "0.000" "False" "23.436" "21" "4" "7" "4" "204" "22.4" "5.83" "28.98" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07904" "55257" "ENSG00000101189" "MRGBP" "A8C4L5; hsa:55257; Q9NV56" "HATs acetylate histones" "" "1" "0" "0.973" "0.901" "0.932" "0.863" "0.957" "0.906" "0.904" "0.924" "0.840" "1246.9" "1213.0" "1123.5" "1161.8" "1075.9" "1193.6" "1130.0" "1127.6" "1152.3" "1047.4" "" "" "" "" "" "" "" "" "" "" "1105.8" "1004.8" "980.3" "868.9" "897.1" "1096.5" "955.1" "932.0" "1056.8" "1047.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6707241685728679125" "False" "High" "IsMasterProtein" "Q9NY93" "Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1" "0.000" "False" "23.413" "8" "4" "4" "4" "547" "61.6" "9.26" "14.43" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54606" "ENSG00000136271" "DDX56" "A4D2K9; C9JV95; hsa:54606; Q6IAE2; Q9H9I8; Q9NY93" "" "" "0" "0" "1.032" "1.014" "1.048" "0.997" "0.905" "0.610" "0.638" "0.663" "0.420" "414.2" "427.3" "420.0" "433.9" "413.1" "374.9" "252.6" "264.1" "274.8" "174.0" "" "" "" "" "" "" "" "" "" "" "367.3" "354.0" "366.5" "324.5" "344.5" "344.4" "213.5" "218.3" "252.0" "174.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2891424664368030590" "False" "High" "IsMasterProtein" "Q8N6T3" "ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARFGAP1 PE=1 SV=2" "0.000" "False" "23.407" "16" "5" "5" "5" "406" "44.6" "5.66" "20.39" "5" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "55738" "ENSG00000101199" "ARFGAP1" "B7Z3U0; B7Z8H8; B7ZBI3; E1P5I9; E7EV62; hsa:55738; Q6PK71; Q8N6T3; Q96KC4; Q96T02; Q9NSU3; Q9NVF6; Q9UIL0" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Clathrin-mediated endocytosis; XBP1(S) activates chaperone genes" "IL-18 signaling pathway" "5" "0" "0.947" "0.988" "0.938" "0.960" "0.921" "0.863" "0.812" "0.929" "2.571" "331.0" "313.4" "327.1" "310.5" "317.7" "304.7" "285.8" "268.7" "307.4" "850.9" "" "" "" "" "" "" "" "" "" "" "293.5" "259.6" "285.4" "232.2" "264.9" "279.9" "241.5" "222.1" "281.9" "850.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585910940532122349" "False" "High" "IsMasterProtein" "Q5U5X0" "Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1" "0.000" "False" "23.399" "38" "4" "11" "4" "104" "11.9" "9.66" "39.88" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf05347" "90624" "ENSG00000186687" "LYRM7" "A8MPQ9; hsa:90624; Q5U5X0; Q86Y68" "" "Mitochondrial complex III assembly" "1" "0" "1.037" "1.084" "1.031" "1.042" "1.078" "0.918" "1.112" "1.112" "0.498" "1086.9" "1127.1" "1178.1" "1120.9" "1132.8" "1171.4" "997.8" "1208.1" "1208.7" "541.6" "" "" "" "" "" "" "" "" "" "" "963.8" "933.6" "1028.0" "838.3" "944.6" "1076.1" "843.3" "998.6" "1108.5" "541.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739885640391199971" "False" "High" "IsMasterProtein" "Q8IY57" "YY1-associated factor 2 OS=Homo sapiens OX=9606 GN=YAF2 PE=1 SV=3" "0.000" "False" "23.367" "22" "3" "5" "2" "180" "19.9" "9.72" "20.94" "3" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "10138" "ENSG00000015153" "YAF2" "A8K5P0; B4DFU3; G3V465; hsa:10138; Q8IY57; Q99710" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "" "2" "0" "1.123" "0.766" "0.807" "0.893" "0.887" "0.889" "1.028" "0.912" "0.564" "33.1" "37.1" "25.3" "26.7" "29.5" "29.3" "29.4" "34.0" "30.1" "18.6" "" "" "" "" "" "" "" "" "" "" "29.3" "30.7" "22.1" "19.9" "24.6" "26.9" "24.8" "28.1" "27.6" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3918971924664803467" "False" "High" "IsMasterProtein" "Q14088" "Ras-related protein Rab-33A OS=Homo sapiens OX=9606 GN=RAB33A PE=1 SV=2" "0.000" "False" "23.296" "24" "6" "7" "6" "237" "26.6" "7.88" "18.83" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00071" "9363" "ENSG00000134594" "RAB33A" "hsa:9363; Q14088; Q5JUZ6; Q92465" "RAB geranylgeranylation; TBC/RABGAPs" "" "2" "0" "1.095" "0.948" "1.136" "1.038" "1.102" "1.003" "0.980" "0.977" "0.788" "397.7" "435.5" "377.0" "451.7" "412.9" "438.3" "398.8" "390.0" "388.5" "313.4" "" "" "" "" "" "" "" "" "" "" "352.7" "360.7" "328.9" "337.8" "344.3" "402.6" "337.1" "322.3" "356.3" "313.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721497203732723661" "False" "High" "IsMasterProtein" "P01591" "Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=4" "0.000" "False" "23.283" "42" "6" "7" "6" "159" "18.1" "5.24" "22.37" "6" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf15097" "3512" "ENSG00000132465" "JCHAIN" "hsa:3512; P01591" "Cell surface interactions at the vascular wall; Scavenging of heme from plasma" "" "2" "0" "1.042" "0.998" "1.183" "1.002" "1.057" "1.008" "1.089" "1.035" "0.497" "314.7" "327.8" "314.0" "372.4" "315.4" "332.6" "317.3" "342.9" "325.9" "156.4" "" "" "" "" "" "" "" "" "" "" "279.1" "271.6" "274.0" "278.5" "263.0" "305.5" "268.2" "283.4" "298.9" "156.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2488299377452803712" "False" "High" "IsMasterProtein" "Q8N9T8" "Protein KRI1 homolog OS=Homo sapiens OX=9606 GN=KRI1 PE=1 SV=3" "0.000" "False" "23.259" "9" "4" "6" "4" "703" "82.5" "5.14" "15.18" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05178, Pf12936" "65095" "ENSG00000129347" "KRI1" "hsa:65095; Q2M1R5; Q2M1R7; Q7L5J7; Q8N9T8; Q96G92; Q9BU50; Q9H6I1; Q9H978" "" "" "0" "0" "1.105" "0.977" "1.075" "1.014" "0.973" "0.991" "1.042" "0.993" "0.831" "165.5" "183.0" "161.7" "178.0" "167.8" "161.0" "164.0" "172.5" "164.4" "137.5" "" "" "" "" "" "" "" "" "" "" "146.8" "151.6" "141.1" "133.1" "140.0" "147.9" "138.6" "142.5" "150.7" "137.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "23.197" "12" "6" "6" "6" "529" "59.5" "8.92" "21.66" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "" "3" "0" "1.000" "0.974" "1.057" "0.970" "1.000" "1.013" "0.943" "0.950" "0.998" "594.8" "594.6" "579.2" "628.5" "577.0" "595.0" "602.5" "560.8" "564.8" "593.4" "" "" "" "" "" "" "" "" "" "" "527.5" "492.5" "505.4" "470.0" "481.1" "546.6" "509.2" "463.5" "518.0" "593.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "23.196" "4" "5" "6" "4" "1239" "142.0" "7.46" "20.16" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "Oxidative Stress Induced Senescence" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "7" "0" "0.932" "0.876" "1.038" "0.965" "0.923" "1.090" "0.926" "0.873" "1.185" "197.1" "183.7" "172.6" "204.6" "190.2" "182.0" "214.9" "182.6" "172.0" "233.5" "" "" "" "" "" "" "" "" "" "" "174.8" "152.2" "150.6" "153.0" "158.6" "167.2" "181.6" "150.9" "157.7" "233.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.000" "False" "23.183" "18" "6" "6" "6" "409" "43.7" "6.70" "21.51" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.099" "0.989" "1.123" "1.131" "1.060" "1.186" "1.100" "1.011" "0.756" "274.8" "301.9" "271.8" "308.5" "310.8" "291.4" "325.8" "302.4" "277.8" "207.9" "" "" "" "" "" "" "" "" "" "" "243.7" "250.1" "237.2" "230.7" "259.1" "267.7" "275.4" "249.9" "254.8" "207.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5970229024696725622" "False" "High" "IsMasterProtein" "O96020" "G1/S-specific cyclin-E2 OS=Homo sapiens OX=9606 GN=CCNE2 PE=1 SV=1" "0.000" "False" "23.165" "13" "4" "6" "4" "404" "46.7" "7.83" "22.24" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "9134" "ENSG00000175305" "CCNE2" "hsa:9134; O95439; O96020" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response" "miRNA regulation of DNA damage response; Cell cycle; Parkinson's disease pathway; Retinoblastoma gene in cancer; PI3K-Akt signaling pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; NF1 copy number variation syndrome ; DNA damage response" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8347343991909543181" "False" "High" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "0.000" "False" "23.163" "7" "8" "8" "8" "963" "105.0" "7.05" "21.75" "8" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron uptake and transport" "Iron metabolism in placenta; Ferroptosis" "3" "0" "1.026" "0.892" "1.144" "0.960" "0.893" "0.999" "0.657" "0.937" "6.742" "435.5" "446.7" "388.4" "498.1" "418.2" "388.9" "435.0" "286.2" "407.9" "2936.0" "" "" "" "" "" "" "" "" "" "" "386.2" "370.1" "338.9" "372.5" "348.7" "357.2" "367.6" "236.5" "374.1" "2936.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "High" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.000" "False" "23.154" "18" "8" "8" "8" "412" "46.6" "7.18" "26.46" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.880" "0.867" "0.964" "0.836" "0.825" "0.884" "0.662" "0.875" "5.023" "660.0" "580.5" "572.5" "636.2" "551.7" "544.7" "583.6" "436.9" "577.7" "3315.5" "" "" "" "" "" "" "" "" "" "" "585.3" "480.9" "499.6" "475.8" "460.1" "500.3" "493.2" "361.2" "529.9" "3315.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486901378795353796" "False" "High" "IsMasterProtein" "Q9H8H3" "Thiol S-methyltransferase TMT1A OS=Homo sapiens OX=9606 GN=TMT1A PE=1 SV=1" "0.000" "False" "23.115" "17" "3" "4" "3" "244" "28.3" "8.38" "15.11" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf08241" "25840" "ENSG00000185432" "TMT1A" "hsa:25840; Q9H7R3; Q9H8H3; Q9UHZ7; Q9Y422" "Neutrophil degranulation" "" "1" "0" "1.117" "1.151" "1.216" "1.212" "1.171" "1.030" "1.091" "1.082" "0.775" "415.6" "464.4" "478.5" "505.5" "503.8" "486.9" "428.0" "453.5" "449.8" "322.3" "" "" "" "" "" "" "" "" "" "" "368.6" "384.7" "417.5" "378.0" "420.1" "447.3" "361.8" "374.9" "412.6" "322.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469574299663466694" "False" "High" "IsMasterProtein" "P11233" "Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1" "0.000" "False" "23.087" "23" "4" "5" "4" "206" "23.6" "7.11" "20.07" "4" "cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00071" "5898" "ENSG00000006451" "RALA" "A4D1W3; hsa:5898; P11233" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; p38MAPK events" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "8" "0" "1.012" "0.941" "0.878" "0.943" "0.942" "0.992" "0.962" "1.029" "0.547" "346.4" "350.5" "325.9" "304.1" "326.6" "326.3" "343.5" "333.3" "356.5" "189.4" "" "" "" "" "" "" "" "" "" "" "307.2" "290.3" "284.3" "227.4" "272.4" "299.7" "290.3" "275.5" "326.9" "189.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.000" "False" "23.072" "22" "3" "7" "3" "140" "14.6" "8.46" "21.61" "3" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "0.929" "1.028" "1.024" "0.963" "0.925" "0.965" "1.050" "0.992" "0.576" "345.0" "320.5" "354.8" "353.5" "332.2" "319.2" "333.1" "362.4" "342.4" "198.7" "" "" "" "" "" "" "" "" "" "" "306.0" "265.5" "309.6" "264.3" "277.0" "293.2" "281.6" "299.6" "314.0" "198.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "23.070" "12" "5" "6" "5" "441" "51.1" "5.76" "28.05" "5" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "1.037" "0.843" "1.038" "1.002" "0.980" "1.019" "0.178" "0.928" "17.830" "223.0" "231.1" "188.1" "231.5" "223.5" "218.5" "227.1" "39.6" "207.0" "3975.3" "" "" "" "" "" "" "" "" "" "" "197.7" "191.5" "164.1" "173.1" "186.3" "200.8" "192.0" "32.7" "189.8" "3975.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9028171991778450679" "False" "High" "IsMasterProtein" "P27540" "Aryl hydrocarbon receptor nuclear translocator OS=Homo sapiens OX=9606 GN=ARNT PE=1 SV=1" "0.000" "False" "23.069" "5" "3" "4" "3" "789" "86.6" "6.54" "11.48" "3" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "405" "ENSG00000143437" "ARNT" "B2R9H1; C4AMA1; F8WAP6; hsa:405; P27540; Q59ED4; Q5QP39; Q8NDC7" "PPARA activates gene expression; NPAS4 regulates expression of target genes; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor" "Angiogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; 6q16 copy number variation" "16" "0" "0.777" "0.675" "0.593" "0.581" "0.473" "0.475" "0.610" "0.820" "1.099" "77.2" "60.0" "52.1" "45.8" "44.9" "36.5" "36.7" "47.1" "63.3" "84.9" "" "" "" "" "" "" "" "" "" "" "68.5" "49.7" "45.5" "34.2" "37.4" "33.6" "31.0" "38.9" "58.1" "84.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147874032451066507" "False" "High" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "0.000" "False" "23.067" "17" "7" "8" "7" "470" "52.9" "7.46" "27.96" "7" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116, Pf21271, Pf21273" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "0.991" "0.937" "0.883" "0.937" "0.808" "0.816" "0.660" "1.015" "5.810" "324.4" "321.4" "303.9" "286.4" "303.9" "262.0" "264.8" "214.2" "329.5" "1885.0" "" "" "" "" "" "" "" "" "" "" "287.7" "266.2" "265.2" "214.2" "253.4" "240.7" "223.8" "177.0" "302.2" "1885.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298785526974998210" "False" "High" "IsMasterProtein" "Q9BTU6" "Phosphatidylinositol 4-kinase type 2-alpha OS=Homo sapiens OX=9606 GN=PI4K2A PE=1 SV=1" "0.000" "False" "23.050" "11" "4" "5" "4" "479" "54.0" "8.29" "16.62" "4" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454" "55361" "ENSG00000155252" "PI4K2A" "D3DR59; hsa:55361; Q9BTU6; Q9NSG8" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway" "5" "0" "0.962" "0.926" "1.070" "1.031" "1.005" "1.053" "1.056" "0.997" "0.735" "447.5" "430.3" "414.6" "478.7" "461.5" "449.6" "471.4" "472.6" "446.1" "329.0" "" "" "" "" "" "" "" "" "" "" "396.8" "356.5" "361.7" "358.0" "384.9" "413.0" "398.4" "390.7" "409.1" "329.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "High" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.000" "False" "23.048" "18" "3" "5" "3" "220" "25.4" "10.07" "20.94" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "tRNA processing in the nucleus" "" "1" "0" "0.984" "0.942" "0.994" "0.944" "0.878" "0.861" "0.876" "0.880" "0.653" "236.2" "232.3" "222.4" "234.8" "222.9" "207.4" "203.4" "206.9" "207.7" "154.3" "" "" "" "" "" "" "" "" "" "" "209.5" "192.4" "194.1" "175.6" "185.9" "190.5" "171.9" "171.1" "190.5" "154.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "680199301258843894" "False" "High" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "0.000" "False" "23.034" "19" "5" "6" "5" "277" "31.3" "5.15" "19.08" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.960" "0.977" "0.982" "0.936" "0.909" "1.099" "1.072" "1.125" "2.323" "546.6" "524.6" "534.1" "536.7" "511.9" "497.0" "600.7" "586.0" "614.8" "1269.7" "" "" "" "" "" "" "" "" "" "" "484.8" "434.6" "466.0" "401.4" "426.8" "456.6" "507.7" "484.3" "563.8" "1269.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1844756928667547842" "False" "High" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "0.000" "False" "23.033" "10" "3" "3" "3" "459" "48.8" "7.66" "15.05" "3" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "Q9NWU1" "Mitochondrial protein degradation" "Mitochondrial fatty acid synthesis pathway" "2" "0" "1.037" "1.021" "1.108" "1.055" "1.179" "1.066" "1.097" "1.003" "0.552" "638.4" "661.9" "652.0" "707.3" "673.7" "752.7" "680.5" "700.2" "640.6" "352.7" "" "" "" "" "" "" "" "" "" "" "566.1" "548.3" "568.9" "529.0" "561.8" "691.5" "575.1" "578.7" "587.5" "352.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8300178027695563917" "False" "High" "IsMasterProtein" "P34059" "N-acetylgalactosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GALNS PE=1 SV=1" "0.000" "False" "23.026" "11" "6" "7" "6" "522" "58.0" "6.74" "23.96" "6" "" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf00884, Pf14707" "2588" "ENSG00000141012" "GALNS" "hsa:2588; P34059; Q86VK3" "Neutrophil degranulation; Keratan sulfate degradation; MPS IV - Morquio syndrome A" "Glycosaminoglycan degradation" "4" "0" "0.994" "1.037" "1.026" "1.021" "1.045" "0.957" "1.017" "0.962" "0.576" "675.6" "671.8" "700.3" "693.5" "689.5" "706.2" "646.6" "687.1" "649.8" "388.9" "" "" "" "" "" "" "" "" "" "" "599.1" "556.5" "611.0" "518.6" "574.9" "648.8" "546.5" "568.0" "596.0" "388.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "23.017" "25" "3" "7" "3" "118" "13.7" "8.79" "22.94" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Osteoclast signaling; Proximal tubule transport" "7" "0" "0.965" "0.881" "0.889" "0.808" "0.972" "0.833" "0.888" "0.920" "0.552" "1801.6" "1739.4" "1586.7" "1600.8" "1456.2" "1751.7" "1500.6" "1600.4" "1657.8" "993.9" "" "" "" "" "" "" "" "" "" "" "1597.6" "1440.8" "1384.5" "1197.2" "1214.3" "1609.2" "1268.3" "1322.9" "1520.4" "993.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144550306187805462" "False" "High" "IsMasterProtein" "Q68E01" "Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1" "0.000" "False" "23.009" "7" "5" "5" "5" "1043" "118.0" "5.80" "19.38" "5" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf10189" "65123" "ENSG00000143624; ENSG00000262826" "INTS3" "A8K1W0; B4DQC8; B4E3U9; D3DV57; hsa:65123; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q68E01; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.952" "1.043" "1.080" "1.121" "0.919" "1.073" "1.049" "0.949" "1.555" "153.8" "146.4" "160.3" "166.1" "172.3" "141.3" "165.1" "161.3" "145.9" "239.1" "" "" "" "" "" "" "" "" "" "" "136.4" "121.2" "139.9" "124.2" "143.7" "129.8" "139.5" "133.3" "133.8" "239.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2870938991305949224" "False" "High" "IsMasterProtein" "P15848" "Arylsulfatase B OS=Homo sapiens OX=9606 GN=ARSB PE=1 SV=1" "0.000" "False" "23.003" "10" "5" "6" "5" "533" "59.6" "8.21" "22.08" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "411" "ENSG00000113273" "ARSB" "B2RC20; hsa:411; P15848; Q8N322; Q9UDI9" "Neutrophil degranulation; CS/DS degradation; Glycosphingolipid catabolism; The activation of arylsulfatases; MPS VI - Maroteaux-Lamy syndrome" "Glycosaminoglycan degradation" "6" "0" "1.038" "0.962" "0.977" "1.047" "1.006" "1.051" "0.992" "1.013" "0.807" "491.1" "509.7" "472.2" "479.8" "514.1" "494.0" "515.9" "487.2" "497.3" "396.1" "" "" "" "" "" "" "" "" "" "" "435.5" "422.2" "412.0" "358.8" "428.7" "453.8" "436.0" "402.7" "456.1" "396.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3062212909163771863" "False" "High" "IsMasterProtein" "P19838" "Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2" "0.000" "False" "22.945" "5" "4" "4" "4" "968" "105.3" "5.40" "15.76" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4790" "ENSG00000109320" "NFKB1" "A8K5Y5; B3KVE8; hsa:4790; P19838; Q68D84; Q86V43; Q8N4X7; Q9NZC0" "Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; Activation of NF-kappaB in B cells; HCMV Early Events; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Selenium metabolism and selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; LTF danger signal response pathway; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; Th17 cell differentiation pathway; Lung pathology of COVID-19; Ulcerative colitis signaling; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Inflammatory bowel disease signaling; Role of ROS in COVID-19 endothelial dysfunction; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; TROP2 regulatory signaling; Autophagy in pancreatic ductal adenocarcinoma; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; 10q22q23 copy number variation; IL-19 signaling pathway; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway" "151" "0" "1.046" "0.965" "1.075" "1.039" "0.948" "1.114" "0.767" "0.922" "6.110" "213.4" "223.2" "205.8" "229.4" "221.6" "202.2" "237.6" "163.6" "196.7" "1303.6" "" "" "" "" "" "" "" "" "" "" "189.2" "184.9" "179.6" "171.6" "184.8" "185.8" "200.8" "135.3" "180.4" "1303.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "22.943" "14" "6" "6" "6" "364" "39.7" "5.35" "20.26" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "" "2" "0" "1.012" "0.989" "0.989" "0.993" "0.961" "1.152" "0.939" "1.018" "3.674" "546.2" "552.5" "539.9" "540.0" "542.4" "525.0" "629.1" "512.9" "556.0" "2006.5" "" "" "" "" "" "" "" "" "" "" "484.3" "457.7" "471.1" "403.9" "452.3" "482.3" "531.7" "424.0" "510.0" "2006.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-90342498941342912" "False" "High" "IsMasterProtein" "Q8N8R5" "Mitochondrial protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1" "0.000" "False" "22.936" "12" "4" "5" "4" "385" "43.4" "8.09" "17.53" "4" "other metabolic processes" "other membranes;mitochondrion" "" "Pf10561" "205327" "ENSG00000178074" "C2orf69" "hsa:205327; Q8N8R5; Q8NE30" "" "" "0" "0" "1.126" "1.097" "1.080" "1.072" "1.117" "1.122" "1.036" "0.933" "0.692" "330.7" "372.5" "362.9" "357.3" "354.4" "369.3" "371.1" "342.7" "308.7" "228.9" "" "" "" "" "" "" "" "" "" "" "293.3" "308.6" "316.7" "267.2" "295.5" "339.2" "313.6" "283.3" "283.1" "228.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "22.886" "40" "4" "28" "3" "81" "9.1" "8.43" "75.72" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "TGF-beta receptor signaling activates SMADs; UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "7" "1" "0.969" "0.938" "0.928" "0.887" "0.926" "0.875" "0.961" "0.937" "0.504" "3083.6" "2988.6" "2892.0" "2861.4" "2735.5" "2856.4" "2696.9" "2963.8" "2888.0" "1554.7" "" "" "" "" "" "" "" "" "" "" "2734.5" "2475.6" "2523.4" "2139.9" "2281.1" "2623.9" "2279.3" "2449.8" "2648.7" "1554.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.000" "False" "22.885" "21" "4" "5" "4" "183" "20.6" "4.67" "20.66" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Ciliary landscape" "3" "0" "1.041" "1.080" "0.859" "1.009" "1.135" "0.882" "1.023" "1.074" "0.797" "415.5" "432.6" "448.9" "356.9" "419.4" "471.6" "366.3" "425.2" "446.3" "331.3" "" "" "" "" "" "" "" "" "" "" "368.5" "358.4" "391.7" "266.9" "349.7" "433.2" "309.6" "351.4" "409.4" "331.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.000" "False" "22.869" "41" "4" "10" "4" "70" "8.2" "10.10" "31.32" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "16" "0" "0.917" "0.943" "0.868" "1.029" "1.119" "0.910" "0.825" "0.778" "0.914" "240.3" "220.4" "226.6" "208.5" "247.4" "268.9" "218.6" "198.2" "187.0" "219.6" "" "" "" "" "" "" "" "" "" "" "213.1" "182.6" "197.7" "155.9" "206.3" "247.0" "184.8" "163.9" "171.5" "219.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8487408262660345487" "False" "High" "IsMasterProtein" "P11388" "DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3" "0.000" "False" "22.815" "3" "4" "4" "3" "1531" "174.3" "8.72" "15.44" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7153" "ENSG00000131747" "TOP2A" "B2RTS1; hsa:7153; P11388; Q71UN1; Q71UQ5; Q9HB24; Q9HB25; Q9HB26; Q9UP44; Q9UQP9" "SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex" "Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer" "5" "0" "1.029" "0.948" "1.085" "0.952" "0.904" "0.896" "0.915" "0.924" "0.894" "419.4" "431.6" "397.8" "455.3" "399.5" "379.2" "375.7" "383.8" "387.4" "375.1" "" "" "" "" "" "" "" "" "" "" "371.9" "357.5" "347.1" "340.5" "333.1" "348.3" "317.5" "317.2" "355.3" "375.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.000" "False" "22.811" "31" "5" "7" "5" "157" "17.8" "8.66" "23.33" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "0.994" "0.995" "0.957" "0.927" "0.904" "0.861" "0.754" "0.794" "1.441" "301.9" "300.1" "300.4" "288.9" "279.8" "273.1" "259.9" "227.6" "239.6" "435.2" "" "" "" "" "" "" "" "" "" "" "267.8" "248.6" "262.1" "216.0" "233.3" "250.8" "219.6" "188.2" "219.8" "435.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4299442073717893558" "False" "High" "IsMasterProtein" "Q9Y6A4" "Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1" "0.000" "False" "22.808" "21" "4" "6" "4" "193" "22.8" "9.76" "23.08" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf05018" "29105" "ENSG00000070761" "CFAP20" "hsa:29105; Q9Y6A4" "" "" "0" "0" "1.067" "0.983" "1.080" "1.022" "0.954" "1.075" "1.018" "0.936" "1.733" "1030.7" "1099.9" "1013.3" "1113.1" "1052.9" "983.7" "1108.0" "1048.7" "964.3" "1786.3" "" "" "" "" "" "" "" "" "" "" "914.0" "911.1" "884.2" "832.5" "878.0" "903.6" "936.4" "866.9" "884.4" "1786.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574805230493063036" "False" "High" "IsMasterProtein" "Q9Y3D7" "Mitochondrial import inner membrane translocase subunit TIM16 OS=Homo sapiens OX=9606 GN=PAM16 PE=1 SV=2" "0.000" "False" "22.779" "24" "2" "3" "2" "125" "13.8" "9.70" "18.42" "2" "transport;other biological processes" "other membranes;mitochondrion;other cell component" "" "Pf03656" "51025" "ENSG00000217930; ENSG00000282228" "PAM16" "hsa:51025; Q6I9Z3; Q9H5X3; Q9Y3D7" "Mitochondrial protein import" "" "1" "0" "1.036" "0.961" "1.015" "0.965" "0.996" "0.957" "0.914" "0.998" "0.534" "350.2" "362.7" "336.5" "355.3" "337.8" "348.9" "335.1" "320.0" "349.4" "187.2" "" "" "" "" "" "" "" "" "" "" "310.5" "300.4" "293.6" "265.7" "281.7" "320.5" "283.2" "264.5" "320.5" "187.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1831448905794715132" "False" "High" "IsMasterProtein" "P84098" "Large ribosomal subunit protein eL19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1" "0.000" "False" "22.749" "33" "7" "9" "7" "196" "23.5" "11.47" "26.25" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01280" "6143" "ENSG00000108298" "RPL19" "B2R4K2; P14118; P22908; P84098; Q502Y6; Q7Z6E4" "SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.076" "1.066" "1.058" "1.099" "1.071" "1.120" "1.034" "0.983" "1.000" "652.7" "702.1" "695.9" "690.6" "717.4" "699.0" "730.8" "674.9" "641.7" "652.5" "" "" "" "" "" "" "" "" "" "" "578.8" "581.6" "607.2" "516.5" "598.2" "642.1" "617.6" "557.9" "588.5" "652.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6009114136998479207" "False" "High" "IsMasterProtein" "Q9GZR1" "Sentrin-specific protease 6 OS=Homo sapiens OX=9606 GN=SENP6 PE=1 SV=2" "0.000" "False" "22.749" "6" "6" "6" "6" "1112" "126.1" "6.73" "18.93" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02902" "26054" "ENSG00000112701" "SENP6" "A6NNY9; hsa:26054; O94891; Q5VUL3; Q5VUL4; Q8TBY4; Q9GZR1; Q9UJV5" "" "" "0" "0" "1.152" "1.041" "1.156" "1.127" "1.096" "1.089" "1.058" "1.085" "1.025" "267.8" "308.5" "278.7" "309.6" "301.7" "293.6" "291.7" "283.3" "290.7" "274.6" "" "" "" "" "" "" "" "" "" "" "237.5" "255.5" "243.1" "231.5" "251.6" "269.7" "246.5" "234.1" "266.6" "274.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "22.734" "31" "5" "6" "5" "179" "20.3" "6.74" "24.27" "5" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "1.016" "0.946" "1.026" "1.005" "1.034" "1.108" "1.029" "1.078" "0.511" "754.5" "766.4" "714.1" "773.9" "758.5" "780.0" "835.6" "776.7" "813.1" "385.3" "" "" "" "" "" "" "" "" "" "" "669.1" "634.8" "623.0" "578.8" "632.4" "716.5" "706.2" "642.0" "745.7" "385.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "22.724" "21" "5" "7" "5" "194" "22.1" "10.10" "22.97" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; rRNA modification in the nucleus and cytosol" "Cytoplasmic ribosomal proteins" "20" "0" "0.951" "1.022" "0.996" "1.032" "0.941" "0.908" "0.885" "0.901" "1.831" "1138.1" "1082.8" "1163.2" "1133.8" "1174.1" "1070.5" "1033.5" "1007.2" "1025.7" "2084.2" "" "" "" "" "" "" "" "" "" "" "1009.3" "897.0" "1014.9" "848.0" "979.0" "983.4" "873.5" "832.5" "940.7" "2084.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2918128559095144433" "False" "High" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "0.000" "False" "22.673" "5" "5" "6" "4" "985" "108.1" "8.32" "20.21" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "" "Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "2" "0" "0.998" "1.074" "1.006" "1.048" "0.978" "0.970" "0.866" "1.086" "1.693" "536.4" "535.3" "575.9" "539.9" "562.4" "524.8" "520.1" "464.8" "582.6" "908.1" "" "" "" "" "" "" "" "" "" "" "475.7" "443.4" "502.5" "403.7" "469.0" "482.1" "439.6" "384.2" "534.3" "908.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.000" "False" "22.653" "12" "7" "7" "5" "579" "63.7" "8.87" "22.90" "7" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "" "1" "0" "1.001" "0.978" "1.069" "0.993" "1.023" "0.933" "0.554" "0.979" "8.362" "429.6" "430.2" "420.2" "459.1" "426.6" "439.6" "401.0" "237.8" "420.8" "3592.6" "" "" "" "" "" "" "" "" "" "" "381.0" "356.3" "366.7" "343.3" "355.8" "403.8" "338.9" "196.6" "385.9" "3592.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7312432654099933298" "False" "High" "IsMasterProtein" "Q8WUF5" "RelA-associated inhibitor OS=Homo sapiens OX=9606 GN=PPP1R13L PE=1 SV=4" "0.000" "False" "22.645" "8" "5" "5" "5" "828" "89.0" "6.81" "18.77" "5" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796, Pf14604" "10848" "ENSG00000104881" "PPP1R13L" "hsa:10848; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q8WUF5; Q9Y290" "Regulation of TP53 Activity through Association with Co-factors" "IL-18 signaling pathway" "2" "0" "0.969" "1.017" "1.007" "1.073" "1.068" "1.058" "0.956" "1.190" "1.793" "184.2" "178.4" "187.2" "185.5" "197.7" "196.7" "194.9" "176.1" "219.3" "330.3" "" "" "" "" "" "" "" "" "" "" "163.3" "147.8" "163.4" "138.7" "164.8" "180.7" "164.7" "145.6" "201.1" "330.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6933895130976224833" "False" "High" "IsMasterProtein" "P23511" "Nuclear transcription factor Y subunit alpha OS=Homo sapiens OX=9606 GN=NFYA PE=1 SV=2" "0.000" "False" "22.637" "6" "1" "4" "1" "347" "36.9" "8.94" "23.43" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02045" "4800" "ENSG00000001167" "NFYA" "hsa:4800; P23511; Q8IXU0" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways" "8" "0" "1.071" "1.119" "1.075" "1.092" "1.195" "1.126" "1.207" "1.172" "0.620" "200.4" "214.6" "224.1" "215.3" "218.8" "239.5" "225.7" "241.8" "234.7" "124.3" "" "" "" "" "" "" "" "" "" "" "177.7" "177.8" "195.5" "161.1" "182.4" "220.0" "190.7" "199.9" "215.3" "124.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5738973645522844846" "False" "High" "IsMasterProtein" "Q5MNZ6" "WD repeat domain phosphoinositide-interacting protein 3 OS=Homo sapiens OX=9606 GN=WDR45B PE=1 SV=2" "0.000" "False" "22.613" "14" "4" "4" "3" "344" "38.1" "7.59" "19.46" "4" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf21032" "56270" "ENSG00000141580" "WDR45B" "A0A024R8U4; A0A218N098; hsa:56270; O95328; Q2MCP6; Q5MNZ6; Q6IBN2" "Macroautophagy" "8q11.23 (RB1CC1) copy number variation" "2" "0" "1.085" "1.023" "0.931" "1.074" "1.061" "1.093" "1.036" "0.960" "0.511" "334.7" "363.0" "342.5" "311.7" "359.4" "355.2" "365.8" "346.9" "321.3" "171.1" "" "" "" "" "" "" "" "" "" "" "296.8" "300.7" "298.9" "233.1" "299.7" "326.3" "309.2" "286.7" "294.7" "171.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407060077554528043" "False" "High" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "0.000" "False" "22.559" "15" "6" "6" "6" "446" "50.4" "9.63" "19.21" "6" "" "nucleus" "" "Pf01585" "" "ENSG00000292251" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "1.053" "0.965" "0.971" "0.938" "0.898" "0.915" "0.914" "0.981" "0.827" "476.5" "501.6" "459.7" "462.7" "447.0" "427.7" "436.0" "435.7" "467.7" "394.1" "" "" "" "" "" "" "" "" "" "" "422.6" "415.5" "401.1" "346.1" "372.7" "392.9" "368.5" "360.2" "429.0" "394.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8214160649428381093" "False" "High" "IsMasterProtein" "P22415" "Upstream stimulatory factor 1 OS=Homo sapiens OX=9606 GN=USF1 PE=1 SV=1" "0.000" "False" "22.541" "11" "3" "4" "2" "310" "33.5" "5.54" "17.44" "3" "stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7391" "ENSG00000158773" "USF1" "B2RBZ4; hsa:7391; P22415; Q5SY46; Q7Z5Y1" "Estrogen-dependent gene expression" "7q11.23 copy number variation syndrome; Familial hyperlipidemia type 2" "3" "0" "1.150" "0.888" "1.104" "1.032" "0.903" "1.037" "0.869" "0.920" "1.216" "158.9" "182.8" "141.2" "175.4" "164.0" "143.4" "164.7" "138.2" "146.2" "193.2" "" "" "" "" "" "" "" "" "" "" "140.9" "151.4" "123.2" "131.2" "136.8" "131.8" "139.2" "114.2" "134.1" "193.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6651828163835198711" "False" "High" "IsMasterProtein" "O95997" "Securin OS=Homo sapiens OX=9606 GN=PTTG1 PE=1 SV=1" "0.000" "False" "22.519" "18" "4" "5" "4" "202" "22.0" "6.60" "18.57" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04856" "9232" "ENSG00000164611" "PTTG1" "hsa:9232; O95997" "APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "5" "0" "0.946" "0.993" "0.997" "1.004" "1.001" "1.039" "1.073" "1.147" "1.035" "952.0" "900.7" "944.9" "949.3" "955.7" "952.7" "989.4" "1021.7" "1092.4" "985.1" "" "" "" "" "" "" "" "" "" "" "844.2" "746.1" "824.5" "709.9" "796.9" "875.2" "836.2" "844.5" "1001.9" "985.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "22.515" "33" "6" "11" "6" "156" "18.0" "8.21" "25.70" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "RNA polymerase II transcribes snRNA genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Intronless Pre-mRNAs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "0.958" "0.903" "0.963" "1.016" "0.947" "0.934" "1.022" "0.907" "0.659" "479.6" "459.3" "433.2" "462.0" "487.2" "454.3" "448.0" "490.1" "434.8" "316.2" "" "" "" "" "" "" "" "" "" "" "425.3" "380.5" "378.0" "345.5" "406.3" "417.3" "378.6" "405.1" "398.8" "316.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.000" "False" "22.498" "29" "6" "6" "6" "203" "23.8" "9.26" "22.98" "6" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "0.953" "0.946" "0.993" "0.860" "0.916" "0.955" "0.861" "0.939" "1.311" "917.8" "874.9" "868.0" "911.1" "789.1" "840.7" "876.2" "790.5" "862.2" "1203.3" "" "" "" "" "" "" "" "" "" "" "813.9" "724.7" "757.4" "681.4" "658.0" "772.3" "740.5" "653.4" "790.8" "1203.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8108900187098047619" "False" "High" "IsMasterProtein" "Q9H6U6" "BCAS3 microtubule associated cell migration factor OS=Homo sapiens OX=9606 GN=BCAS3 PE=1 SV=3" "0.000" "False" "22.479" "5" "4" "5" "4" "928" "101.2" "6.70" "13.76" "4" "cell-cell signaling;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12490, Pf21034" "54828" "ENSG00000141376" "BCAS3" "hsa:54828; Q17RM0; Q6KF21; Q8IXI6; Q8NDR8; Q8TDL9; Q8TDM1; Q8WY55; Q9BVF0; Q9H6U6; Q9H957; Q9H9Y9; Q9NXP4" "" "Ectoderm differentiation" "1" "0" "1.098" "0.978" "1.114" "1.084" "0.990" "0.970" "0.986" "0.969" "0.859" "225.3" "247.5" "220.4" "251.1" "244.3" "223.0" "218.6" "222.1" "218.3" "193.4" "" "" "" "" "" "" "" "" "" "" "199.8" "205.0" "192.3" "187.8" "203.7" "204.8" "184.8" "183.6" "200.2" "193.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "22.460" "19" "7" "10" "7" "351" "40.6" "8.79" "32.06" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of PLK1 Activity at G2/M Transition; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Mitochondrial protein degradation; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "75" "0" "0.966" "0.952" "0.973" "0.874" "0.909" "0.950" "1.047" "0.985" "0.674" "1430.2" "1382.2" "1361.6" "1392.0" "1250.6" "1299.8" "1358.4" "1497.8" "1409.4" "964.5" "" "" "" "" "" "" "" "" "" "" "1268.3" "1145.0" "1188.1" "1041.0" "1042.8" "1194.0" "1148.1" "1238.1" "1292.6" "964.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6547533640129493555" "False" "High" "IsMasterProtein" "Q9H9Y4" "GPN-loop GTPase 2 OS=Homo sapiens OX=9606 GN=GPN2 PE=1 SV=2" "0.000" "False" "22.444" "16" "4" "5" "4" "310" "34.5" "5.25" "18.94" "4" "" "" "other molecular function" "Pf03029" "54707" "ENSG00000142751" "GPN2" "hsa:54707; Q96HG4; Q9H9Y4; Q9NUE1; Q9NW30" "" "" "0" "0" "0.922" "0.820" "0.958" "0.995" "1.030" "0.900" "1.001" "0.910" "0.572" "313.2" "288.8" "256.9" "300.0" "311.6" "322.6" "281.9" "313.7" "285.0" "179.3" "" "" "" "" "" "" "" "" "" "" "277.8" "239.3" "224.1" "224.3" "259.8" "296.4" "238.2" "259.3" "261.4" "179.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1562013219529803649" "False" "High" "IsMasterProtein" "P15391" "B-lymphocyte antigen CD19 OS=Homo sapiens OX=9606 GN=CD19 PE=1 SV=6" "0.000" "False" "22.437" "8" "4" "4" "4" "556" "61.1" "4.98" "16.45" "4" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "" "930" "ENSG00000177455" "CD19" "A0N0P9; F5H635; hsa:930; P15391; Q96S68; Q9BRD6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "B cell receptor signaling pathway; Complement system; PI3K-Akt signaling pathway; Leukocyte-intrinsic Hippo pathway functions; 16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "13" "0" "1.021" "0.925" "0.927" "0.977" "1.047" "0.943" "0.882" "1.224" "0.917" "425.4" "434.5" "393.4" "394.5" "415.5" "445.6" "401.3" "375.1" "520.9" "390.0" "" "" "" "" "" "" "" "" "" "" "377.3" "359.9" "343.2" "295.0" "346.5" "409.3" "339.1" "310.0" "477.8" "390.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7649239600803351534" "False" "High" "IsMasterProtein" "Q96JY6" "PDZ and LIM domain protein 2 OS=Homo sapiens OX=9606 GN=PDLIM2 PE=1 SV=1" "0.000" "False" "22.429" "17" "5" "6" "5" "352" "37.4" "8.72" "21.70" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "64236" "ENSG00000120913" "PDLIM2" "D3DSR5; hsa:64236; J3KNH4; Q7Z584; Q86WM8; Q8WZ29; Q96JY6; Q9H4L9; Q9H7I2" "" "" "0" "0" "0.898" "1.047" "0.941" "0.913" "0.952" "0.943" "0.938" "0.960" "0.857" "940.8" "844.7" "984.7" "885.7" "859.1" "895.2" "887.3" "882.2" "903.0" "805.9" "" "" "" "" "" "" "" "" "" "" "834.3" "699.7" "859.2" "662.4" "716.3" "822.3" "749.9" "729.2" "828.2" "805.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7206962341954350531" "False" "High" "IsMasterProtein" "Q6DHV7" "Adenosine deaminase-like protein OS=Homo sapiens OX=9606 GN=ADAL PE=1 SV=2" "0.000" "False" "22.414" "13" "5" "7" "5" "355" "40.2" "6.32" "23.70" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf00962" "161823" "ENSG00000168803" "ADAL" "A6NHZ3; B4DQM8; hsa:161823; Q6DHV7" "Purine salvage; Abacavir metabolism" "" "2" "0" "1.133" "0.953" "1.023" "1.065" "1.010" "1.082" "1.033" "0.968" "0.685" "499.7" "566.1" "476.1" "511.1" "532.3" "504.8" "540.5" "516.3" "483.9" "342.3" "" "" "" "" "" "" "" "" "" "" "443.1" "468.9" "415.4" "382.2" "443.9" "463.7" "456.8" "426.8" "443.8" "342.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1468504121694453873" "False" "High" "IsMasterProtein" "Q9H930" "Nuclear body protein SP140-like protein OS=Homo sapiens OX=9606 GN=SP140L PE=1 SV=3" "0.000" "False" "22.409" "7" "4" "5" "1" "580" "67.0" "8.48" "19.56" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01342, Pf03172" "93349" "ENSG00000185404" "SP140L" "hsa:93349; Q2M375; Q4ZG65; Q9BSP3; Q9H930" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-404480449398085068" "False" "High" "IsMasterProtein" "P51809" "Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3" "0.000" "False" "22.380" "16" "4" "6" "4" "220" "24.9" "8.60" "23.69" "4" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "6845" "ENSG00000124333; ENSG00000292366" "VAMP7" "hsa:6845; P51809; Q53GY7; Q7Z409; Q9H4A7" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Interleukin-12 signaling" "" "6" "0" "1.056" "1.020" "1.075" "1.066" "1.080" "1.014" "1.054" "1.011" "0.919" "665.6" "703.2" "678.8" "715.3" "709.8" "719.0" "674.8" "701.3" "672.6" "611.4" "" "" "" "" "" "" "" "" "" "" "590.2" "582.5" "592.3" "534.9" "591.9" "660.5" "570.3" "579.7" "616.9" "611.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7850572796846009162" "False" "High" "IsMasterProtein" "P52435" "DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1" "0.000" "False" "22.352" "24" "3" "6" "3" "117" "13.3" "5.86" "21.72" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "5439" "ENSG00000005075" "POLR2J" "A5D6V8; hsa:5439; O43375; P52435" "RNA polymerase II transcribes snRNA genes; TP53 Regulates Transcription of DNA Repair Genes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "0.969" "1.054" "0.904" "0.973" "1.044" "0.903" "0.877" "0.917" "1.532" "722.0" "699.3" "760.7" "653.0" "702.4" "754.1" "651.9" "633.4" "661.9" "1106.1" "" "" "" "" "" "" "" "" "" "" "640.3" "579.3" "663.8" "488.4" "585.7" "692.7" "550.9" "523.6" "607.0" "1106.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.000" "False" "22.348" "14" "6" "6" "6" "426" "48.3" "6.77" "20.04" "6" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Interferon gamma signaling; Interferon alpha/beta signaling" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "7" "0" "0.955" "0.948" "0.972" "0.986" "0.973" "0.883" "0.788" "0.814" "1.725" "194.1" "185.4" "184.0" "188.7" "191.3" "189.0" "171.4" "153.0" "157.9" "334.9" "" "" "" "" "" "" "" "" "" "" "172.1" "153.5" "160.6" "141.1" "159.5" "173.6" "144.8" "126.5" "144.8" "334.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "22.302" "9" "6" "9" "3" "552" "59.7" "9.04" "29.60" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2873927276967630041" "False" "High" "IsMasterProtein" "Q2TAZ0" "Autophagy-related protein 2 homolog A OS=Homo sapiens OX=9606 GN=ATG2A PE=1 SV=3" "0.000" "False" "22.289" "3" "7" "8" "6" "1938" "212.7" "5.88" "23.83" "7" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624" "23130" "ENSG00000110046" "ATG2A" "hsa:23130; O43154; Q14DM2; Q2TAZ0; Q6ZTV2; Q7Z6K8; Q8IVY5; Q8TAI8; Q96HH7" "" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "4" "0" "1.088" "0.981" "0.836" "1.092" "0.952" "0.952" "1.002" "0.884" "0.830" "172.4" "187.5" "169.1" "144.0" "188.3" "164.0" "164.1" "172.7" "152.3" "143.1" "" "" "" "" "" "" "" "" "" "" "152.8" "155.3" "147.5" "107.7" "157.0" "150.7" "138.7" "142.8" "139.7" "143.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2707692795518285071" "False" "High" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "0.000" "False" "22.283" "10" "6" "7" "6" "631" "73.2" "8.15" "23.22" "6" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762, Pf21673" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "0.981" "1.106" "1.003" "0.796" "0.839" "0.907" "0.597" "0.783" "4.746" "272.0" "266.8" "301.0" "272.9" "216.6" "228.2" "246.8" "162.3" "213.0" "1291.2" "" "" "" "" "" "" "" "" "" "" "241.2" "221.0" "262.6" "204.1" "180.6" "209.6" "208.6" "134.2" "195.3" "1291.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155365173843636052" "False" "High" "IsMasterProtein" "P48507" "Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1" "0.000" "False" "22.261" "19" "5" "5" "5" "274" "30.7" "6.02" "17.87" "5" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00248" "2730" "ENSG00000023909" "GCLM" "A8K334; D3DT45; hsa:2730; M5A959; P48507; Q6FHC1; Q9NPX9; Q9NU74" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; NRF2-ARE regulation; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "15" "0" "0.918" "0.808" "0.969" "0.929" "0.841" "0.864" "0.718" "0.800" "4.170" "161.8" "148.6" "130.8" "156.7" "150.4" "136.2" "139.8" "116.2" "129.5" "674.9" "" "" "" "" "" "" "" "" "" "" "143.5" "123.1" "114.1" "117.2" "125.4" "125.1" "118.2" "96.1" "118.8" "674.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589862746651834702" "False" "High" "IsMasterProtein" "Q9UBW5" "Bridging integrator 2 OS=Homo sapiens OX=9606 GN=BIN2 PE=1 SV=3" "0.000" "False" "22.188" "10" "6" "8" "6" "565" "61.8" "5.15" "26.07" "6" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf03114, Pf21532" "51411" "ENSG00000110934" "BIN2" "B7Z6F3; F5H0W4; hsa:51411; Q86VV0; Q9NWK4; Q9UBW5; Q9UKN4" "Neutrophil degranulation; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "TYROBP causal network in microglia" "3" "0" "0.992" "0.932" "0.961" "0.968" "0.950" "0.974" "0.877" "0.994" "1.289" "918.0" "910.4" "855.5" "882.2" "889.1" "872.2" "894.4" "805.5" "912.1" "1183.3" "" "" "" "" "" "" "" "" "" "" "814.1" "754.1" "746.4" "659.8" "741.4" "801.2" "755.9" "665.8" "836.5" "1183.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "High" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.000" "False" "22.177" "20" "4" "4" "4" "271" "30.0" "5.47" "16.17" "4" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "13" "0" "0.899" "0.998" "1.102" "0.960" "0.929" "1.288" "0.823" "1.047" "5.166" "51.2" "46.0" "51.1" "56.4" "49.1" "47.5" "65.9" "42.1" "53.6" "264.4" "" "" "" "" "" "" "" "" "" "" "45.4" "38.1" "44.6" "42.2" "40.9" "43.7" "55.7" "34.8" "49.1" "264.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.000" "False" "22.160" "11" "6" "7" "6" "557" "61.8" "5.97" "23.23" "6" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "1.068" "1.061" "1.047" "1.039" "1.097" "1.141" "1.068" "1.138" "1.286" "492.2" "525.7" "522.1" "515.6" "511.6" "540.2" "561.8" "525.6" "560.3" "633.0" "" "" "" "" "" "" "" "" "" "" "436.5" "435.5" "455.5" "385.6" "426.6" "496.2" "474.8" "434.5" "513.9" "633.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.000" "False" "22.131" "36" "4" "10" "4" "90" "9.4" "9.99" "28.91" "4" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "0.905" "0.901" "1.048" "0.781" "0.657" "0.512" "1.092" "1.032" "0.400" "2739.8" "2480.2" "2469.3" "2871.8" "2141.1" "1800.2" "1401.8" "2991.9" "2828.2" "1095.4" "" "" "" "" "" "" "" "" "" "" "2429.6" "2054.5" "2154.6" "2147.7" "1785.4" "1653.7" "1184.7" "2473.0" "2593.9" "1095.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5142259406840293622" "False" "High" "IsMasterProtein" "Q14738" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1" "0.000" "False" "22.067" "11" "5" "7" "3" "602" "69.9" "8.13" "19.21" "5" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5528" "ENSG00000112640" "PPP2R5D" "A8K3I9; B5BUA6; hsa:5528; O00494; O00696; Q14738; Q15171; Q5TC39" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; DARPP-32 events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "33" "0" "1.134" "1.105" "1.280" "1.092" "1.145" "1.157" "0.347" "1.073" "13.993" "56.4" "64.0" "62.3" "72.2" "61.6" "64.6" "65.3" "19.6" "60.6" "789.7" "" "" "" "" "" "" "" "" "" "" "50.0" "53.0" "54.4" "54.0" "51.4" "59.4" "55.2" "16.2" "55.5" "789.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224423870794083930" "False" "High" "IsMasterProtein" "P49356" "Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1" "0.000" "False" "22.053" "12" "5" "7" "5" "437" "48.7" "5.82" "20.93" "5" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00432" "100529261; 2342" "ENSG00000257365" "FNTB" "B2RDX6; B4E1A0; hsa:100529261; hsa:2342; P49356" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing" "" "3" "0" "0.936" "0.936" "0.973" "1.058" "1.012" "1.123" "1.138" "1.130" "1.185" "451.3" "422.3" "422.4" "439.1" "477.5" "456.5" "506.9" "513.4" "509.9" "534.7" "" "" "" "" "" "" "" "" "" "" "400.2" "349.8" "368.6" "328.4" "398.2" "419.4" "428.4" "424.4" "467.7" "534.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.000" "False" "22.031" "17" "3" "5" "3" "200" "22.2" "4.68" "15.71" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "1.027" "1.083" "1.194" "0.904" "1.108" "0.832" "0.794" "1.131" "2.084" "17.7" "18.2" "19.2" "21.2" "16.0" "19.6" "14.8" "14.1" "20.1" "37.0" "" "" "" "" "" "" "" "" "" "" "15.7" "15.1" "16.8" "15.8" "13.4" "18.0" "12.5" "11.6" "18.4" "37.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-852377223734167343" "False" "High" "IsMasterProtein" "Q4G176" "Malonate--CoA ligase ACSF3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3" "0.000" "False" "22.019" "13" "8" "9" "7" "576" "64.1" "8.37" "26.78" "8" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00501, Pf13193" "197322" "ENSG00000176715" "ACSF3" "A8K4J8; C9JQL6; hsa:197322; Q4G176; Q6INA0; Q8N2F7" "Synthesis of very long-chain fatty acyl-CoAs" "" "1" "0" "1.030" "0.948" "1.308" "1.023" "0.911" "1.164" "0.931" "0.977" "2.361" "303.1" "312.2" "287.3" "396.5" "310.1" "276.2" "353.0" "282.3" "296.3" "715.8" "" "" "" "" "" "" "" "" "" "" "268.8" "258.6" "250.7" "296.6" "258.6" "253.7" "298.3" "233.4" "271.7" "715.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3637812855525000132" "False" "High" "IsMasterProtein" "Q2KHR2" "DNA-binding protein RFX7 OS=Homo sapiens OX=9606 GN=RFX7 PE=1 SV=2" "0.000" "False" "22.010" "4" "5" "6" "5" "1460" "157.3" "6.61" "20.02" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257" "64864" "ENSG00000181827" "RFX7" "hsa:64864; Q2KHR2; Q6ZRR1; Q6ZTY6; Q8N3J0; Q9H7A9; Q9H956" "" "" "0" "0" "1.070" "0.905" "1.014" "0.889" "1.096" "0.959" "0.776" "0.889" "1.310" "163.1" "174.5" "147.5" "165.4" "145.0" "178.8" "156.5" "126.5" "144.9" "213.7" "" "" "" "" "" "" "" "" "" "" "144.6" "144.5" "128.7" "123.7" "120.9" "164.2" "132.2" "104.6" "132.9" "213.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.000" "False" "21.979" "23" "4" "4" "4" "190" "21.8" "8.90" "15.39" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.031" "0.861" "1.009" "1.071" "0.946" "1.005" "0.890" "1.039" "3.331" "478.4" "493.2" "411.8" "482.5" "512.2" "452.3" "480.7" "425.5" "497.2" "1593.3" "" "" "" "" "" "" "" "" "" "" "424.2" "408.6" "359.3" "360.9" "427.1" "415.5" "406.3" "351.7" "456.0" "1593.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8780259354878837006" "False" "High" "IsMasterProtein" "Q7Z7L7" "Protein zer-1 homolog OS=Homo sapiens OX=9606 GN=ZER1 PE=1 SV=1" "0.000" "False" "21.955" "7" "5" "5" "5" "766" "88.1" "5.62" "16.83" "5" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "10444" "ENSG00000160445" "ZER1" "hsa:10444; O00156; Q5T272; Q5T273; Q7Z7L7" "" "" "0" "0" "0.940" "0.988" "1.062" "1.089" "1.041" "1.005" "1.125" "0.945" "0.716" "468.0" "440.0" "462.3" "497.1" "509.7" "487.1" "470.4" "526.5" "442.3" "335.0" "" "" "" "" "" "" "" "" "" "" "415.0" "364.5" "403.4" "371.7" "425.0" "447.4" "397.5" "435.2" "405.7" "335.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "21.954" "13" "4" "4" "4" "376" "40.1" "5.27" "17.67" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "Protein hydroxylation" "" "1" "0" "1.045" "0.991" "1.167" "1.132" "0.992" "1.156" "0.924" "0.896" "0.769" "315.5" "329.8" "312.7" "368.1" "357.1" "312.9" "364.9" "291.7" "282.7" "242.7" "" "" "" "" "" "" "" "" "" "" "279.8" "273.2" "272.8" "275.3" "297.8" "287.5" "308.4" "241.1" "259.3" "242.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514790625548438605" "False" "High" "IsMasterProtein" "Q8WUX2" "Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1" "0.000" "False" "21.940" "30" "4" "5" "4" "184" "20.9" "5.43" "20.77" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf04752" "494143" "ENSG00000143942" "CHAC2" "hsa:494143; Q8WUX2; Q8WVI8" "Glutathione synthesis and recycling" "" "1" "0" "1.076" "1.016" "1.025" "1.159" "0.983" "1.033" "1.000" "1.093" "0.727" "545.3" "586.6" "554.0" "558.9" "632.0" "536.0" "563.0" "545.5" "595.7" "396.4" "" "" "" "" "" "" "" "" "" "" "483.5" "485.9" "483.4" "418.0" "527.0" "492.4" "475.8" "450.9" "546.4" "396.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1286800557191181783" "False" "High" "IsMasterProtein" "Q14686" "Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3" "0.000" "False" "21.938" "3" "4" "4" "4" "2063" "219.0" "9.36" "15.61" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13820" "23054" "ENSG00000198646" "NCOA6" "A6NLF1; B2RMN5; E1P5P7; hsa:23054; Q14686; Q9NTZ9; Q9UH74; Q9UK86" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of WDR5-containing histone-modifying complexes; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Kleefstra syndrome" "15" "0" "0.991" "0.893" "0.915" "0.843" "0.971" "1.133" "0.900" "0.979" "1.016" "122.5" "121.3" "109.4" "112.1" "103.3" "119.0" "138.7" "110.3" "119.9" "124.5" "" "" "" "" "" "" "" "" "" "" "108.6" "100.5" "95.4" "83.8" "86.1" "109.3" "117.3" "91.1" "110.0" "124.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792882720935006206" "False" "High" "IsMasterProtein" "Q9HAV4" "Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1" "0.000" "False" "21.884" "5" "7" "8" "7" "1204" "136.2" "5.80" "27.27" "7" "RNA metabolism OR transcription;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19273" "57510" "ENSG00000124571" "XPO5" "hsa:57510; Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9HAV4; Q9NT89; Q9NW39; Q9ULC9" "MicroRNA (miRNA) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Primary ovarian insufficiency" "4" "0" "0.987" "0.858" "0.983" "0.962" "0.829" "1.071" "0.527" "0.976" "9.916" "362.6" "358.0" "311.3" "356.5" "348.7" "300.7" "388.5" "190.9" "353.9" "3596.0" "" "" "" "" "" "" "" "" "" "" "321.6" "296.5" "271.6" "266.6" "290.8" "276.3" "328.4" "157.8" "324.6" "3596.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108263305464485910" "False" "High" "IsMasterProtein" "O95644" "Nuclear factor of activated T-cells, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=NFATC1 PE=1 SV=3" "0.000" "False" "21.847" "4" "5" "5" "5" "943" "101.2" "6.99" "16.27" "5" "stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4772" "ENSG00000131196" "NFATC1" "B5B2M4; B5B2M5; B5B2M6; B5B2M7; B5B2M8; B5B2M9; B5B2N1; hsa:4772; O95644; Q12865; Q15793; Q2M1S3" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "Heart development; RANKL/RANK signaling pathway; Ectoderm differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Wnt signaling; Vitamin D in inflammatory diseases; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; Th17 cell differentiation pathway; DYRK1A involvement regarding cell proliferation in brain development; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; IL-26 signaling pathways; T-cell receptor signaling pathway" "20" "0" "0.912" "0.883" "0.845" "0.929" "0.949" "0.926" "0.873" "0.905" "2.211" "145.2" "132.4" "128.2" "122.7" "134.9" "137.9" "134.4" "126.8" "131.4" "321.1" "" "" "" "" "" "" "" "" "" "" "128.8" "109.7" "111.8" "91.8" "112.5" "126.7" "113.6" "104.8" "120.5" "321.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832536973652725080" "False" "High" "IsMasterProtein" "Q96C90" "Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3" "0.000" "False" "21.845" "17" "2" "7" "2" "147" "15.9" "4.86" "46.51" "2" "stress response;other biological processes" "other cell component" "enzyme regulator activity" "Pf05361" "26472" "ENSG00000173457" "PPP1R14B" "hsa:26472; Q504S7; Q7KZD7; Q96C90" "" "" "0" "0" "1.047" "1.056" "1.059" "1.100" "1.065" "1.061" "1.109" "1.112" "0.686" "349.7" "366.2" "369.3" "370.3" "384.7" "372.4" "371.2" "387.8" "388.7" "240.0" "" "" "" "" "" "" "" "" "" "" "310.1" "303.3" "322.3" "276.9" "320.7" "342.1" "313.7" "320.5" "356.5" "240.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311926917854502333" "False" "High" "IsMasterProtein" "O43414" "ERI1 exoribonuclease 3 OS=Homo sapiens OX=9606 GN=ERI3 PE=1 SV=2" "0.000" "False" "21.844" "11" "4" "5" "4" "337" "37.2" "8.07" "20.29" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00929" "79033" "ENSG00000117419" "ERI3" "B1AK98; hsa:79033; O43414; Q5T2T7; Q5T2T9; Q5TG35; Q9BQA0; Q9UEB4" "" "" "0" "0" "0.962" "0.953" "1.023" "1.028" "1.042" "0.951" "0.983" "0.868" "0.548" "1141.9" "1098.4" "1088.3" "1168.7" "1173.7" "1190.2" "1085.5" "1122.9" "990.8" "625.7" "" "" "" "" "" "" "" "" "" "" "1012.6" "909.9" "949.6" "874.1" "978.7" "1093.3" "917.4" "928.1" "908.7" "625.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7897691878290275966" "False" "High" "IsMasterProtein" "Q9Y680" "Peptidyl-prolyl cis-trans isomerase FKBP7 OS=Homo sapiens OX=9606 GN=FKBP7 PE=1 SV=2" "0.000" "False" "21.843" "29" "6" "6" "6" "222" "25.8" "6.32" "17.60" "6" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf00254, Pf13202" "51661" "ENSG00000079150" "FKBP7" "hsa:51661; Q4ZG70; Q6V3B2; Q86U65; Q96DA4; Q9Y680; Q9Y6B0" "" "" "0" "0" "0.973" "0.968" "0.875" "0.850" "0.889" "0.690" "0.875" "0.983" "0.532" "397.2" "386.4" "384.5" "347.5" "337.8" "353.3" "274.1" "347.5" "390.5" "211.5" "" "" "" "" "" "" "" "" "" "" "352.2" "320.1" "335.5" "259.9" "281.6" "324.5" "231.7" "287.3" "358.1" "211.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.000" "False" "21.824" "34" "5" "8" "5" "167" "19.1" "8.37" "28.37" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "RAB geranylgeranylation" "" "1" "0" "1.046" "1.004" "1.116" "1.115" "1.132" "1.063" "1.020" "0.954" "0.578" "553.4" "578.8" "555.5" "617.5" "616.8" "626.4" "588.1" "564.7" "527.9" "320.1" "" "" "" "" "" "" "" "" "" "" "490.8" "479.5" "484.7" "461.8" "514.3" "575.4" "497.0" "466.7" "484.2" "320.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.000" "False" "21.749" "3" "3" "3" "3" "1375" "157.2" "5.08" "13.52" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "Ub-specific processing proteases" "" "1" "0" "0.960" "0.932" "1.108" "0.982" "0.871" "1.067" "0.612" "0.980" "11.610" "104.6" "100.4" "97.5" "115.9" "102.7" "91.1" "111.6" "64.0" "102.5" "1214.6" "" "" "" "" "" "" "" "" "" "" "92.8" "83.2" "85.1" "86.7" "85.6" "83.7" "94.3" "52.9" "94.0" "1214.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "High" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.000" "False" "21.749" "7" "3" "3" "3" "573" "62.6" "5.21" "11.30" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "" "1" "0" "0.830" "0.573" "0.983" "0.934" "0.789" "0.845" "0.203" "0.798" "21.500" "46.8" "38.9" "26.8" "46.0" "43.7" "36.9" "39.6" "9.5" "37.4" "1006.8" "" "" "" "" "" "" "" "" "" "" "41.5" "32.2" "23.4" "34.4" "36.5" "33.9" "33.4" "7.9" "34.3" "1006.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2424139350801194209" "False" "High" "IsMasterProtein" "Q9NRG0" "Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1" "0.000" "False" "21.747" "31" "3" "8" "3" "131" "14.7" "5.10" "30.85" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54108" "ENSG00000104472" "CHRAC1" "hsa:54108; Q9NRG0" "" "Acute viral myocarditis" "1" "0" "1.116" "1.002" "1.078" "1.075" "1.134" "1.073" "1.170" "1.061" "0.855" "645.0" "719.7" "646.4" "695.3" "693.7" "731.4" "691.9" "754.5" "684.3" "551.7" "" "" "" "" "" "" "" "" "" "" "572.0" "596.1" "564.0" "520.0" "578.4" "671.9" "584.8" "623.6" "627.6" "551.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939496649029224586" "False" "High" "IsMasterProtein" "P51812" "Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1" "0.000" "False" "21.735" "9" "6" "8" "2" "740" "83.7" "6.89" "30.37" "6" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6197" "ENSG00000177189" "RPS6KA3" "B2R9V4; hsa:6197; P51812; Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "18" "0" "1.008" "0.645" "0.744" "0.703" "0.816" "0.853" "0.836" "0.924" "1.382" "31.3" "31.5" "20.2" "23.3" "22.0" "25.5" "26.7" "26.1" "28.9" "43.2" "" "" "" "" "" "" "" "" "" "" "27.7" "26.1" "17.6" "17.4" "18.3" "23.4" "22.5" "21.6" "26.5" "43.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266332044031462775" "False" "High" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "0.000" "False" "21.733" "27" "5" "7" "5" "174" "19.8" "8.54" "29.48" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "1.001" "0.976" "1.028" "1.039" "1.036" "1.156" "0.583" "1.098" "12.474" "561.8" "562.3" "548.5" "577.7" "583.9" "581.8" "649.7" "327.5" "617.1" "7007.7" "" "" "" "" "" "" "" "" "" "" "498.2" "465.7" "478.6" "432.0" "486.9" "534.5" "549.1" "270.7" "566.0" "7007.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8613494787005004283" "False" "High" "IsMasterProtein" "Q9BWJ5" "Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1" "0.000" "False" "21.714" "56" "4" "10" "4" "86" "10.1" "6.35" "38.42" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07189" "83443" "ENSG00000169976" "SF3B5" "B2R568; hsa:83443; Q7RTV1; Q9BWJ5" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.894" "0.892" "0.917" "0.918" "0.907" "0.898" "0.859" "0.864" "0.660" "1352.5" "1208.8" "1206.2" "1240.5" "1242.1" "1226.7" "1214.8" "1161.4" "1168.6" "893.3" "" "" "" "" "" "" "" "" "" "" "1199.4" "1001.3" "1052.4" "927.7" "1035.7" "1126.9" "1026.7" "959.9" "1071.7" "893.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "21.707" "30" "3" "4" "3" "151" "16.3" "10.05" "24.41" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "1.030" "0.964" "1.081" "1.110" "0.900" "1.009" "0.935" "1.049" "2.494" "294.9" "303.7" "284.4" "318.9" "327.4" "265.5" "297.5" "275.7" "309.4" "735.5" "" "" "" "" "" "" "" "" "" "" "261.5" "251.6" "248.1" "238.5" "273.0" "243.9" "251.5" "227.9" "283.8" "735.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1727135258656817627" "False" "High" "IsMasterProtein" "Q9BTL3" "RNA guanine-N7 methyltransferase activating subunit OS=Homo sapiens OX=9606 GN=RAMAC PE=1 SV=1" "0.000" "False" "21.688" "41" "5" "6" "5" "118" "14.4" "8.94" "23.08" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15320" "83640" "ENSG00000169612" "RAMAC" "hsa:83640; Q2M1J8; Q9BTL3" "" "15q25 copy number variation" "1" "0" "0.773" "0.806" "0.781" "0.796" "0.858" "0.826" "0.850" "0.878" "0.459" "742.8" "573.8" "598.9" "580.5" "591.5" "637.6" "613.9" "631.3" "652.0" "341.3" "" "" "" "" "" "" "" "" "" "" "658.7" "475.3" "522.6" "434.1" "493.2" "585.7" "518.8" "521.8" "598.0" "341.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.000" "False" "21.685" "12" "8" "8" "8" "733" "75.4" "9.32" "26.60" "8" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "UCH proteinases" "" "1" "0" "1.066" "1.085" "1.048" "1.076" "0.968" "1.187" "1.015" "1.153" "2.497" "416.4" "443.8" "451.9" "436.3" "448.0" "403.2" "494.2" "422.8" "480.1" "1039.8" "" "" "" "" "" "" "" "" "" "" "369.3" "367.6" "394.3" "326.3" "373.6" "370.4" "417.7" "349.5" "440.3" "1039.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378421800270237029" "False" "High" "IsMasterProtein" "Q5TZA2" "Rootletin OS=Homo sapiens OX=9606 GN=CROCC PE=1 SV=2" "0.000" "False" "21.675" "2" "5" "9" "4" "2017" "228.3" "5.49" "24.02" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf15035" "9696" "ENSG00000058453" "CROCC" "hsa:9696; Q2VHY3; Q5TZA2; Q66GT7; Q7Z2L4; Q7Z5D7" "" "" "0" "0" "0.956" "0.848" "0.843" "0.916" "0.822" "0.969" "0.746" "0.854" "1.413" "277.7" "265.4" "235.4" "234.2" "254.5" "228.2" "269.2" "207.2" "237.0" "392.5" "" "" "" "" "" "" "" "" "" "" "246.3" "219.9" "205.4" "175.2" "212.2" "209.6" "227.6" "171.3" "217.4" "392.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "21.648" "16" "5" "8" "5" "329" "34.3" "5.19" "30.14" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "0.988" "0.992" "1.119" "0.981" "0.987" "1.001" "0.977" "1.038" "1.088" "697.8" "689.7" "692.3" "780.6" "684.6" "688.5" "698.3" "682.0" "724.0" "759.0" "" "" "" "" "" "" "" "" "" "" "618.8" "571.3" "604.0" "583.8" "570.9" "632.5" "590.2" "563.7" "664.0" "759.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "21.637" "20" "7" "7" "7" "288" "32.7" "10.58" "23.82" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.031" "0.936" "0.986" "0.925" "0.782" "0.788" "0.941" "1.039" "0.596" "951.1" "980.5" "890.0" "938.0" "879.5" "744.1" "749.0" "895.1" "988.4" "566.8" "" "" "" "" "" "" "" "" "" "" "843.4" "812.2" "776.5" "701.5" "733.4" "683.5" "633.1" "739.9" "906.5" "566.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "21.630" "6" "3" "5" "3" "795" "88.9" "6.54" "16.21" "3" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "1.097" "0.799" "0.848" "1.156" "0.783" "0.964" "0.679" "0.836" "3.997" "40.9" "44.9" "32.7" "34.7" "47.3" "32.0" "39.4" "27.8" "34.2" "163.4" "" "" "" "" "" "" "" "" "" "" "36.3" "37.2" "28.5" "25.9" "39.4" "29.4" "33.3" "22.9" "31.3" "163.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "High" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.000" "False" "21.612" "11" "3" "5" "3" "284" "30.4" "6.54" "17.22" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "0.994" "1.011" "0.982" "1.067" "1.011" "0.985" "0.961" "0.860" "1.055" "691.8" "687.7" "699.5" "679.3" "737.8" "699.6" "681.3" "665.1" "594.7" "730.1" "" "" "" "" "" "" "" "" "" "" "613.5" "569.7" "610.3" "508.0" "615.2" "642.6" "575.8" "549.7" "545.4" "730.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "High" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.000" "False" "21.603" "5" "6" "7" "4" "1071" "120.8" "6.70" "20.78" "6" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle; RHO GTPases Activate Formins; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "" "8" "1" "1.013" "1.002" "1.039" "0.943" "0.971" "0.908" "0.880" "1.146" "1.511" "338.4" "342.8" "338.9" "351.6" "319.0" "328.7" "307.3" "297.7" "387.7" "511.4" "" "" "" "" "" "" "" "" "" "" "300.1" "284.0" "295.7" "263.0" "266.0" "301.9" "259.7" "246.1" "355.6" "511.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740288424381142174" "False" "High" "IsMasterProtein" "O43181" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS4 PE=1 SV=1" "0.000" "False" "21.598" "21" "3" "3" "3" "175" "20.1" "10.30" "16.31" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf04800" "4724" "ENSG00000164258" "NDUFS4" "hsa:4724; O43181; Q9BS69" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.923" "1.035" "1.019" "1.000" "1.109" "0.974" "1.058" "1.001" "0.091" "299.7" "276.6" "310.3" "305.5" "299.8" "332.5" "291.9" "317.2" "300.0" "27.3" "" "" "" "" "" "" "" "" "" "" "265.8" "229.1" "270.8" "228.5" "250.0" "305.4" "246.7" "262.2" "275.2" "27.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "21.585" "20" "5" "5" "5" "227" "26.5" "8.41" "18.39" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "" "2" "0" "0.920" "0.916" "0.915" "0.850" "0.973" "0.810" "0.742" "0.802" "0.856" "423.0" "389.0" "387.6" "387.0" "359.7" "411.5" "342.6" "314.0" "339.2" "362.1" "" "" "" "" "" "" "" "" "" "" "375.1" "322.2" "338.2" "289.5" "299.9" "378.0" "289.5" "259.5" "311.1" "362.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248535501308075701" "False" "High" "IsMasterProtein" "P62879" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Homo sapiens OX=9606 GN=GNB2 PE=1 SV=3" "0.000" "False" "21.553" "20" "6" "7" "2" "340" "37.3" "6.00" "19.38" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "2783" "ENSG00000172354" "GNB2" "B3KPU1; hsa:2783; P11016; P54312; P62879" "G alpha (i) signalling events; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "36" "0" "1.092" "0.874" "1.119" "1.132" "1.028" "1.154" "0.831" "1.081" "0.974" "71.7" "78.3" "62.6" "80.2" "81.1" "73.6" "82.7" "59.5" "77.5" "69.8" "" "" "" "" "" "" "" "" "" "" "63.5" "64.8" "54.6" "60.0" "67.6" "67.6" "69.9" "49.2" "71.1" "69.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563797319587415269" "False" "High" "IsMasterProtein" "P25208" "Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2" "0.000" "False" "21.550" "12" "3" "8" "3" "207" "22.8" "4.59" "27.98" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "4801" "ENSG00000120837" "NFYB" "A8K7B9; hsa:4801; P25208; Q96IY8" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "" "5" "0" "0.971" "0.948" "0.914" "0.853" "0.956" "0.899" "0.879" "0.909" "0.483" "905.2" "878.8" "858.1" "827.4" "772.5" "865.5" "814.0" "795.4" "822.6" "437.6" "" "" "" "" "" "" "" "" "" "" "802.7" "728.0" "748.7" "618.8" "644.1" "795.1" "688.0" "657.5" "754.5" "437.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.000" "False" "21.546" "37" "6" "10" "6" "153" "17.9" "5.06" "30.91" "6" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "E3 ubiquitin ligases ubiquitinate target proteins" "" "1" "0" "0.987" "0.977" "0.980" "0.915" "0.929" "0.990" "1.002" "0.982" "0.590" "959.8" "947.6" "938.2" "940.8" "877.9" "891.4" "949.7" "961.6" "942.8" "566.7" "" "" "" "" "" "" "" "" "" "" "851.1" "784.9" "818.6" "703.6" "732.1" "818.8" "802.7" "794.8" "864.6" "566.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3538958500289371582" "False" "High" "IsMasterProtein" "P49336" "Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1" "0.000" "False" "21.520" "11" "5" "6" "3" "464" "53.3" "8.57" "22.12" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1024" "ENSG00000132964" "CDK8" "hsa:1024; P49336; Q5VUF3; Q6ISB5" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription" "Sterol regulatory element-binding proteins (SREBP) signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; lncRNA in canonical Wnt signaling and colorectal cancer" "11" "1" "0.965" "0.924" "1.009" "0.938" "0.959" "0.965" "0.941" "0.968" "0.856" "466.2" "449.9" "430.8" "470.3" "437.4" "447.0" "450.0" "438.6" "451.4" "399.1" "" "" "" "" "" "" "" "" "" "" "413.4" "372.6" "375.9" "351.7" "364.7" "410.6" "380.3" "362.5" "414.0" "399.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "21.515" "15" "4" "4" "4" "325" "35.4" "8.38" "18.74" "4" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "Mitochondrial translation elongation" "" "1" "0" "1.031" "0.996" "1.036" "0.998" "0.963" "1.050" "0.223" "0.988" "14.547" "250.6" "258.4" "249.6" "259.7" "250.0" "241.3" "263.1" "55.9" "247.7" "3645.9" "" "" "" "" "" "" "" "" "" "" "222.3" "214.1" "217.8" "194.2" "208.5" "221.7" "222.3" "46.2" "227.2" "3645.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561010377563702326" "False" "High" "IsMasterProtein" "Q8WX92" "Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1" "0.000" "False" "21.506" "7" "4" "4" "4" "580" "65.7" "6.13" "16.11" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06209" "25920" "ENSG00000188986" "NELFB" "A0A0X1KG71; A2BFA3; hsa:25920; Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; NTRK3 as a dependence receptor" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation; 5q35 copy number variation" "18" "0" "0.805" "0.888" "0.822" "0.852" "0.863" "0.831" "0.666" "0.901" "4.853" "273.5" "220.1" "242.9" "224.9" "232.9" "236.1" "227.1" "182.1" "246.3" "1327.3" "" "" "" "" "" "" "" "" "" "" "242.5" "182.3" "211.9" "168.2" "194.2" "216.9" "192.0" "150.5" "225.9" "1327.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4237649288618835376" "False" "High" "IsMasterProtein" "Q9NUP9" "Protein lin-7 homolog C OS=Homo sapiens OX=9606 GN=LIN7C PE=1 SV=1" "0.000" "False" "21.458" "26" "5" "5" "5" "197" "21.8" "8.43" "18.60" "5" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf00595, Pf02828" "55327" "ENSG00000148943" "LIN7C" "hsa:55327; Q9NUP9" "Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle" "" "3" "0" "0.904" "1.242" "0.823" "0.803" "0.908" "0.777" "0.795" "0.881" "0.802" "274.5" "248.2" "341.1" "226.0" "220.5" "249.4" "213.2" "218.2" "242.0" "220.2" "" "" "" "" "" "" "" "" "" "" "243.4" "205.6" "297.6" "169.0" "183.9" "229.1" "180.2" "180.3" "221.9" "220.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "21.453" "5" "5" "5" "5" "1042" "112.1" "6.60" "18.46" "5" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "Rap1 signalling" "MAPK cascade" "2" "0" "1.031" "0.959" "1.075" "1.048" "0.975" "0.986" "0.894" "0.925" "1.931" "555.3" "572.7" "532.5" "596.8" "582.2" "541.6" "547.5" "496.6" "513.8" "1072.1" "" "" "" "" "" "" "" "" "" "" "492.5" "474.4" "464.6" "446.3" "485.5" "497.5" "462.7" "410.5" "471.3" "1072.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.000" "False" "21.450" "12" "6" "6" "6" "467" "53.9" "6.33" "17.26" "6" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "0.921" "0.850" "0.873" "0.892" "0.925" "0.822" "0.905" "0.894" "0.624" "321.4" "295.9" "273.1" "280.6" "286.8" "297.3" "264.2" "290.7" "287.4" "200.6" "" "" "" "" "" "" "" "" "" "" "285.0" "245.1" "238.3" "209.8" "239.1" "273.1" "223.3" "240.3" "263.6" "200.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5388836657935240768" "False" "High" "IsMasterProtein" "Q12872" "Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3" "0.000" "False" "21.447" "5" "4" "7" "4" "951" "104.8" "8.05" "25.10" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01805, Pf09750" "6433" "ENSG00000061936" "SFSWAP" "B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7" "" "mRNA processing" "1" "0" "1.088" "1.129" "1.084" "1.052" "0.999" "1.012" "0.953" "1.010" "1.551" "453.7" "493.8" "512.3" "491.9" "477.1" "453.3" "459.2" "432.6" "458.4" "703.5" "" "" "" "" "" "" "" "" "" "" "402.4" "409.1" "447.0" "367.8" "397.8" "416.4" "388.1" "357.6" "420.4" "703.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "21.424" "13" "6" "9" "6" "518" "58.2" "8.13" "27.61" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Mitochondrial tRNA aminoacylation" "Selenium metabolism and selenoproteins" "2" "0" "1.026" "0.974" "1.095" "1.020" "1.103" "1.450" "1.401" "1.499" "1.040" "643.6" "660.6" "626.7" "705.0" "656.8" "709.9" "933.2" "901.5" "965.1" "669.4" "" "" "" "" "" "" "" "" "" "" "570.8" "547.2" "546.8" "527.3" "547.7" "652.1" "788.7" "745.2" "885.1" "669.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.000" "False" "21.418" "10" "6" "7" "6" "597" "67.6" "5.85" "18.34" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.035" "0.975" "1.027" "1.086" "1.032" "0.970" "1.037" "0.948" "0.687" "189.8" "196.4" "185.1" "194.9" "206.0" "195.8" "184.0" "196.8" "179.9" "130.5" "" "" "" "" "" "" "" "" "" "" "168.3" "162.7" "161.5" "145.8" "171.8" "179.8" "155.5" "162.7" "165.0" "130.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002844298631346291" "False" "High" "IsMasterProtein" "Q53H47" "Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens OX=9606 GN=SETMAR PE=1 SV=2" "0.000" "False" "21.411" "7" "4" "4" "4" "684" "78.0" "7.14" "16.83" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01359, Pf05033, Pf17906" "6419" "ENSG00000170364" "SETMAR" "B4DY74; E7EN68; hsa:6419; Q13579; Q1G668; Q53H47; Q96F41" "" "Histone modifications" "1" "0" "0.984" "0.961" "1.065" "1.059" "1.001" "1.014" "0.967" "1.008" "0.898" "447.7" "440.7" "430.3" "477.0" "474.0" "448.1" "453.8" "432.8" "451.2" "401.8" "" "" "" "" "" "" "" "" "" "" "397.0" "365.0" "375.5" "356.7" "395.3" "411.7" "383.5" "357.7" "413.8" "401.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "High" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.000" "False" "21.409" "5" "6" "8" "6" "1047" "119.8" "5.66" "16.51" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "" "12" "0" "0.912" "0.976" "0.940" "0.908" "1.086" "0.924" "0.903" "0.805" "0.749" "212.9" "194.1" "207.9" "200.1" "193.2" "231.1" "196.6" "192.2" "171.4" "159.4" "" "" "" "" "" "" "" "" "" "" "188.8" "160.8" "181.4" "149.6" "161.1" "212.3" "166.2" "158.8" "157.2" "159.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8334369527451810461" "False" "High" "IsMasterProtein" "Q8NF64" "Zinc finger MIZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZMIZ2 PE=1 SV=2" "0.000" "False" "21.404" "5" "5" "6" "2" "920" "96.5" "7.12" "19.90" "5" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02891" "83637" "ENSG00000122515" "ZMIZ2" "A4D2K7; D3DVL1; hsa:83637; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8NF64; Q8WTX8; Q96Q01; Q9BQH7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6657686065862137180" "False" "High" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "0.000" "False" "21.396" "16" "6" "6" "5" "365" "40.8" "6.04" "21.66" "6" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "" "Nanoparticle triggered autophagic cell death" "1" "0" "1.079" "0.928" "1.029" "1.022" "0.971" "1.009" "0.511" "1.011" "10.633" "199.6" "215.4" "185.2" "205.3" "204.0" "193.9" "201.5" "102.1" "201.8" "2122.9" "" "" "" "" "" "" "" "" "" "" "177.0" "178.4" "161.6" "153.6" "170.1" "178.1" "170.3" "84.4" "185.1" "2122.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.000" "False" "21.390" "23" "5" "8" "5" "204" "22.9" "9.72" "27.99" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.018" "1.039" "1.090" "1.134" "0.898" "0.994" "0.884" "1.055" "2.124" "530.7" "540.4" "551.6" "578.3" "602.1" "476.8" "527.7" "468.9" "560.1" "1127.0" "" "" "" "" "" "" "" "" "" "" "470.6" "447.6" "481.3" "432.5" "502.0" "438.0" "446.0" "387.6" "513.7" "1127.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6037717816811945701" "False" "High" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "0.000" "False" "21.389" "6" "7" "7" "7" "1007" "113.5" "9.16" "20.94" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "0" "1.066" "0.959" "0.986" "1.029" "1.021" "1.015" "0.919" "0.921" "3.159" "453.6" "483.5" "435.1" "447.3" "466.7" "463.2" "460.3" "416.9" "417.7" "1433.0" "" "" "" "" "" "" "" "" "" "" "402.2" "400.5" "379.6" "334.5" "389.2" "425.5" "389.0" "344.6" "383.1" "1433.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4521329794053270042" "False" "High" "IsMasterProtein" "Q66K64" "DDB1- and CUL4-associated factor 15 OS=Homo sapiens OX=9606 GN=DCAF15 PE=1 SV=1" "0.000" "False" "21.382" "10" "5" "5" "5" "600" "66.4" "6.58" "17.22" "5" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf14939" "90379" "ENSG00000132017; ENSG00000288453" "DCAF15" "B3KS86; hsa:90379; Q66K64; Q96DW0; Q9BU31" "" "" "0" "0" "1.003" "0.995" "1.062" "0.981" "1.006" "1.084" "1.102" "1.094" "0.889" "409.4" "410.7" "407.4" "434.7" "401.5" "411.8" "443.7" "451.2" "447.8" "363.8" "" "" "" "" "" "" "" "" "" "" "363.0" "340.2" "355.5" "325.1" "334.8" "378.3" "375.0" "373.0" "410.7" "363.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.000" "False" "21.376" "8" "5" "5" "5" "706" "80.2" "6.70" "17.02" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.010" "0.965" "1.027" "1.045" "0.993" "1.101" "0.842" "0.997" "3.714" "551.6" "556.9" "532.5" "566.7" "576.2" "547.7" "607.5" "464.6" "550.2" "2048.4" "" "" "" "" "" "" "" "" "" "" "489.1" "461.3" "464.6" "423.8" "480.4" "503.1" "513.4" "384.0" "504.6" "2048.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3935713179938084537" "False" "High" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "0.000" "False" "21.355" "11" "4" "6" "4" "312" "34.8" "8.37" "18.92" "4" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "1.074" "0.973" "1.211" "1.067" "1.068" "1.032" "1.024" "0.941" "0.570" "300.9" "323.0" "292.6" "364.4" "321.0" "321.2" "310.4" "308.2" "283.1" "171.5" "" "" "" "" "" "" "" "" "" "" "266.8" "267.6" "255.3" "272.5" "267.7" "295.1" "262.3" "254.7" "259.6" "171.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.000" "False" "21.298" "8" "3" "3" "3" "594" "66.0" "9.19" "12.67" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "1.076" "1.023" "1.184" "1.178" "0.993" "1.008" "1.139" "1.043" "0.664" "225.8" "243.0" "231.0" "267.4" "266.0" "224.4" "227.7" "257.3" "235.6" "149.9" "" "" "" "" "" "" "" "" "" "" "200.3" "201.3" "201.5" "200.0" "221.8" "206.1" "192.4" "212.7" "216.1" "149.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "High" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.000" "False" "21.258" "27" "4" "6" "4" "137" "15.7" "12.02" "21.34" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.058" "1.079" "1.109" "1.119" "1.038" "1.017" "0.829" "0.912" "1.754" "755.2" "798.7" "814.7" "837.6" "845.1" "783.7" "768.2" "625.8" "688.9" "1324.8" "" "" "" "" "" "" "" "" "" "" "669.7" "661.6" "710.9" "626.4" "704.7" "720.0" "649.3" "517.3" "631.8" "1324.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7445573923015050179" "False" "High" "IsMasterProtein" "Q9BYC8" "Large ribosomal subunit protein bL32m OS=Homo sapiens OX=9606 GN=MRPL32 PE=1 SV=1" "0.000" "False" "21.254" "28" "4" "6" "4" "188" "21.4" "9.73" "26.11" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01783" "64983" "ENSG00000106591" "MRPL32" "hsa:64983; Q96Q68; Q9BYC8; Q9P098" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "0.937" "0.965" "1.033" "1.007" "0.948" "1.058" "1.138" "1.033" "0.630" "280.5" "262.9" "270.7" "289.6" "282.4" "265.9" "296.6" "319.3" "289.7" "176.6" "" "" "" "" "" "" "" "" "" "" "248.7" "217.8" "236.2" "216.6" "235.5" "244.2" "250.7" "263.9" "265.7" "176.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9082551203190853772" "False" "High" "IsMasterProtein" "Q16777" "Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4" "0.000" "False" "21.249" "33" "4" "10" "1" "129" "14.0" "10.90" "30.41" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "8338" "ENSG00000184260" "H2AC20" "hsa:8338; Q16777; Q6DRA7; Q8IUE5" "Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ub-specific processing proteases; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Metalloprotease DUBs; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "" "42" "0" "1.211" "0.959" "1.257" "1.367" "0.993" "1.271" "1.070" "1.127" "0.703" "59.2" "71.7" "56.8" "74.4" "80.9" "58.8" "75.2" "63.3" "66.7" "41.6" "" "" "" "" "" "" "" "" "" "" "52.5" "59.4" "49.6" "55.7" "67.5" "54.0" "63.6" "52.3" "61.2" "41.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-768881656379736442" "False" "High" "IsMasterProtein" "Q9BT73" "Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1" "0.000" "False" "21.242" "30" "3" "5" "3" "122" "13.1" "7.88" "14.84" "3" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf10178" "84262" "ENSG00000157778" "PSMG3" "A4D216; A8MPW2; hsa:84262; Q9BT73" "" "" "0" "0" "1.063" "1.073" "1.063" "1.109" "1.041" "1.123" "1.037" "0.955" "0.789" "406.8" "432.3" "436.4" "432.3" "451.0" "423.4" "457.1" "421.9" "388.4" "321.1" "" "" "" "" "" "" "" "" "" "" "360.8" "358.1" "380.7" "323.3" "376.1" "388.9" "386.3" "348.7" "356.2" "321.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "21.201" "17" "6" "11" "4" "381" "43.0" "5.71" "32.62" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "21" "0" "1.028" "1.045" "1.162" "1.099" "0.897" "1.017" "1.000" "1.006" "1.303" "221.5" "227.7" "231.5" "257.5" "243.5" "198.6" "225.3" "221.5" "222.9" "288.5" "" "" "" "" "" "" "" "" "" "" "196.4" "188.7" "202.0" "192.6" "203.0" "182.4" "190.4" "183.0" "204.4" "288.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970253198694079027" "False" "High" "IsMasterProtein" "Q96BW1" "Uracil phosphoribosyltransferase homolog OS=Homo sapiens OX=9606 GN=UPRT PE=1 SV=1" "0.000" "False" "21.175" "13" "4" "7" "4" "309" "33.8" "6.04" "22.78" "4" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf14681" "139596" "ENSG00000094841" "UPRT" "hsa:139596; Q5JRL1; Q5JRL3; Q68DN0; Q96BW1; Q96MW2" "" "Pyrimidine metabolism" "1" "0" "1.134" "1.027" "1.100" "1.198" "1.049" "1.432" "1.313" "1.118" "0.790" "199.5" "226.2" "204.9" "219.4" "239.1" "209.3" "285.6" "261.9" "223.0" "157.6" "" "" "" "" "" "" "" "" "" "" "176.9" "187.3" "178.8" "164.1" "199.3" "192.3" "241.4" "216.5" "204.6" "157.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4489642059379383551" "False" "High" "IsMasterProtein" "Q6PD62" "RNA polymerase-associated protein CTR9 homolog OS=Homo sapiens OX=9606 GN=CTR9 PE=1 SV=1" "0.000" "False" "21.159" "5" "6" "6" "6" "1173" "133.4" "6.77" "18.47" "6" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13181, Pf13374" "9646" "ENSG00000198730" "CTR9" "D3DQV8; hsa:9646; Q15015; Q6PD62" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "0.882" "0.931" "0.841" "0.816" "0.749" "0.795" "0.244" "0.940" "10.245" "82.5" "72.8" "76.8" "69.4" "67.3" "61.8" "65.5" "20.1" "77.5" "844.9" "" "" "" "" "" "" "" "" "" "" "73.1" "60.3" "67.0" "51.9" "56.1" "56.8" "55.4" "16.6" "71.1" "844.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2458914006646188126" "False" "High" "IsMasterProtein" "Q9NYV6" "RNA polymerase I-specific transcription initiation factor RRN3 OS=Homo sapiens OX=9606 GN=RRN3 PE=1 SV=1" "0.000" "False" "21.136" "7" "4" "4" "4" "651" "74.1" "5.63" "15.23" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf05327" "54700" "ENSG00000085721; ENSG00000278494" "RRN3" "A2RTY9; B4E0J7; B4E3T2; hsa:54700; Q3MHU9; Q6IPL4; Q9H4F0; Q9NYV6" "RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape" "" "2" "0" "1.039" "0.933" "1.053" "1.032" "1.021" "1.548" "1.520" "1.488" "1.088" "364.2" "378.3" "340.0" "383.7" "376.0" "371.8" "563.7" "553.7" "542.0" "396.2" "" "" "" "" "" "" "" "" "" "" "323.0" "313.4" "296.6" "286.9" "313.5" "341.6" "476.4" "457.6" "497.1" "396.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1991199370327280785" "False" "High" "IsMasterProtein" "Q9HD26" "Golgi-associated PDZ and coiled-coil motif-containing protein OS=Homo sapiens OX=9606 GN=GOPC PE=1 SV=1" "0.000" "False" "21.112" "11" "6" "6" "6" "462" "50.5" "5.92" "21.11" "6" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595" "57120" "ENSG00000047932" "GOPC" "A6NM30; hsa:57120; Q59FS4; Q969U8; Q9HD26" "RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking" "" "2" "0" "1.576" "0.876" "1.200" "1.037" "0.818" "1.026" "0.099" "0.832" "17.475" "162.7" "256.5" "142.5" "195.3" "168.7" "133.1" "167.0" "16.0" "135.3" "2843.8" "" "" "" "" "" "" "" "" "" "" "144.3" "212.5" "124.3" "146.0" "140.7" "122.3" "141.2" "13.3" "124.1" "2843.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.000" "False" "21.109" "21" "4" "5" "4" "206" "23.6" "10.07" "18.73" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.104" "0.890" "0.952" "0.902" "0.938" "0.972" "0.865" "1.025" "1.812" "570.0" "629.2" "507.6" "542.8" "514.3" "534.6" "553.9" "493.2" "584.4" "1033.1" "" "" "" "" "" "" "" "" "" "" "505.5" "521.2" "442.9" "406.0" "428.8" "491.1" "468.1" "407.7" "535.9" "1033.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.000" "False" "21.085" "11" "5" "5" "5" "495" "56.2" "7.58" "16.80" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "3" "0" "1.007" "0.933" "1.012" "0.972" "0.939" "0.868" "0.799" "0.924" "3.104" "318.1" "320.5" "296.7" "322.0" "309.3" "298.8" "276.3" "254.3" "294.1" "987.6" "" "" "" "" "" "" "" "" "" "" "282.1" "265.4" "258.9" "240.8" "258.0" "274.5" "233.5" "210.2" "269.7" "987.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4531671785395663771" "False" "High" "IsMasterProtein" "Q5SXM8" "DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1" "0.000" "False" "21.080" "13" "2" "3" "2" "178" "19.2" "9.80" "15.05" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf05180" "728489" "ENSG00000213221" "DNLZ" "B2RUX5; B9EJE1; hsa:728489; Q5SXM8" "" "" "0" "0" "1.077" "1.025" "0.997" "1.006" "1.083" "1.173" "1.186" "1.074" "0.422" "187.0" "201.5" "191.7" "186.4" "188.1" "202.5" "219.5" "221.8" "200.8" "79.0" "" "" "" "" "" "" "" "" "" "" "165.9" "166.9" "167.3" "139.4" "156.9" "186.0" "185.5" "183.4" "184.2" "79.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516634271704807455" "False" "High" "IsMasterProtein" "Q9BUK0" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Homo sapiens OX=9606 GN=CHCHD7 PE=1 SV=1" "0.000" "False" "21.056" "42" "3" "3" "3" "85" "10.1" "8.82" "15.10" "3" "cell organization and biogenesis" "mitochondrion" "" "Pf02297" "79145" "ENSG00000170791" "CHCHD7" "A8K223; E9PBH3; hsa:79145; J3KNE9; Q7Z588; Q9BUK0" "Mitochondrial protein import" "" "1" "0" "0.960" "1.001" "1.055" "1.021" "1.020" "0.986" "1.043" "1.049" "0.442" "294.1" "282.2" "294.3" "310.3" "300.3" "300.0" "289.9" "306.7" "308.4" "130.0" "" "" "" "" "" "" "" "" "" "" "260.8" "233.8" "256.7" "232.1" "250.4" "275.6" "245.0" "253.5" "282.8" "130.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519156847082484659" "False" "High" "IsMasterProtein" "Q16695" "Histone H3.1t OS=Homo sapiens OX=9606 GN=H3-4 PE=1 SV=3" "0.000" "False" "21.037" "32" "6" "22" "1" "136" "15.5" "11.12" "69.32" "6" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8290" "ENSG00000168148; ENSG00000285435" "H3-4" "B2R5K3; hsa:8290; Q16695; Q6FGU4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Meiotic synapsis; Formation of the beta-catenin:TCF transactivating complex; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence" "Follicle stimulating hormone (FSH) signaling pathway; Male infertility" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4548517045609742799" "False" "High" "IsMasterProtein" "Q9NVR5" "Protein kintoun OS=Homo sapiens OX=9606 GN=DNAAF2 PE=1 SV=2" "0.000" "False" "21.022" "7" "5" "5" "5" "837" "91.1" "5.20" "17.35" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "" "Pf08190, Pf18201" "55172" "ENSG00000165506" "DNAAF2" "B9WS54; C0JAP7; hsa:55172; Q86TR1; Q86TY8; Q969Z5; Q9NVR5" "" "Ciliopathies" "1" "0" "1.034" "1.003" "1.042" "0.964" "0.849" "0.765" "0.958" "0.914" "0.910" "488.5" "505.1" "489.8" "508.8" "471.0" "414.6" "373.6" "468.1" "446.4" "444.7" "" "" "" "" "" "" "" "" "" "" "433.2" "418.4" "427.4" "380.5" "392.7" "380.8" "315.8" "386.9" "409.4" "444.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8070416439539926882" "False" "High" "IsMasterProtein" "Q96E17" "Ras-related protein Rab-3C OS=Homo sapiens OX=9606 GN=RAB3C PE=1 SV=1" "0.000" "False" "20.983" "15" "3" "8" "2" "227" "25.9" "5.24" "26.89" "3" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "115827" "ENSG00000152932" "RAB3C" "hsa:115827; Q96E17" "RAB geranylgeranylation" "" "1" "0" "1.064" "0.968" "1.091" "1.004" "1.045" "1.050" "1.067" "0.986" "0.557" "487.9" "519.3" "472.1" "532.4" "489.8" "510.0" "512.2" "520.5" "481.3" "271.7" "" "" "" "" "" "" "" "" "" "" "432.7" "430.2" "411.9" "398.2" "408.5" "468.5" "432.9" "430.3" "441.4" "271.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1801185171268448485" "False" "High" "IsMasterProtein" "Q6NTE8" "MRN complex-interacting protein OS=Homo sapiens OX=9606 GN=MRNIP PE=1 SV=2" "0.000" "False" "20.975" "20" "6" "6" "6" "343" "37.7" "8.66" "19.81" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf15749" "51149" "ENSG00000161010; ENSG00000283918" "MRNIP" "B5MD09; E9PAK6; Q6NTE8; Q7Z3D8; Q9BUC1; Q9UN54" "" "" "0" "0" "0.890" "0.785" "0.943" "0.867" "0.969" "0.930" "0.786" "0.873" "0.787" "104.8" "93.3" "82.3" "98.8" "90.8" "101.6" "97.4" "82.4" "91.5" "82.4" "" "" "" "" "" "" "" "" "" "" "92.9" "77.3" "71.8" "73.9" "75.7" "93.3" "82.3" "68.1" "83.9" "82.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845152794455651809" "False" "High" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "0.000" "False" "20.941" "2" "5" "5" "2" "2603" "274.1" "6.52" "16.57" "5" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796, Pf13637" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "0" "1.181" "1.056" "1.496" "0.617" "0.785" "1.382" "0.082" "1.354" "12.512" "8.3" "9.8" "8.8" "12.4" "5.1" "6.5" "11.5" "0.7" "11.3" "104.0" "" "" "" "" "" "" "" "" "" "" "7.4" "8.1" "7.7" "9.3" "4.3" "6.0" "9.7" "0.6" "10.3" "104.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2134905287649132421" "False" "High" "IsMasterProtein" "Q9Y312" "Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2" "0.000" "False" "20.939" "15" "5" "7" "5" "384" "43.4" "5.96" "20.06" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf05282, Pf20981" "25980" "ENSG00000131043" "AAR2" "E1P5S7; hsa:25980; Q9H4F9; Q9P1P3; Q9UFK9; Q9Y312" "" "Ciliary landscape" "1" "0" "0.961" "1.009" "1.020" "0.920" "0.903" "0.958" "0.914" "0.928" "1.377" "786.2" "755.7" "793.4" "802.1" "722.9" "709.8" "753.1" "718.6" "729.4" "1082.4" "" "" "" "" "" "" "" "" "" "" "697.2" "626.0" "692.3" "599.9" "602.8" "652.0" "636.5" "594.0" "668.9" "1082.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-621581403936215319" "False" "High" "IsMasterProtein" "Q96B36" "Proline-rich AKT1 substrate 1 OS=Homo sapiens OX=9606 GN=AKT1S1 PE=1 SV=1" "0.000" "False" "20.939" "14" "3" "4" "3" "256" "27.4" "4.75" "17.75" "3" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf15798" "84335" "ENSG00000204673" "AKT1S1" "A8MTQ1; B2RE93; hsa:84335; J3KPM3; Q96B36; Q96BI4; Q96IK7; Q96NG2; Q9BWR5" "HSF1-dependent transactivation; Constitutive Signaling by AKT1 E17K in Cancer; mTORC1-mediated signalling; AKT phosphorylates targets in the cytosol" "Target of rapamycin signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP" "22" "0" "1.001" "0.927" "0.942" "0.931" "0.902" "0.972" "0.937" "0.871" "0.642" "576.8" "577.6" "534.6" "543.1" "536.7" "520.5" "560.5" "540.3" "502.2" "370.5" "" "" "" "" "" "" "" "" "" "" "511.5" "478.5" "466.5" "406.2" "447.5" "478.2" "473.7" "446.6" "460.6" "370.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3241468308071992901" "False" "High" "IsMasterProtein" "Q8NI08" "Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2" "0.000" "False" "20.932" "5" "4" "4" "4" "942" "106.1" "5.59" "16.05" "4" "stress response;other biological processes" "nucleus" "other molecular function" "Pf01476, Pf07534" "135112" "ENSG00000111912" "NCOA7" "B2RNS2; B7Z2C4; B9EH71; G8JL91; hsa:135112; Q3LID6; Q4G0V1; Q5TF95; Q6IPQ4; Q6NE83; Q86T89; Q8N1W4; Q8NI08" "" "Aryl hydrocarbon receptor pathway" "1" "0" "0.941" "0.909" "1.004" "0.798" "0.895" "0.938" "0.771" "0.837" "1.605" "115.0" "108.3" "104.5" "115.4" "91.8" "103.0" "107.9" "88.6" "96.3" "184.6" "" "" "" "" "" "" "" "" "" "" "102.0" "89.7" "91.2" "86.3" "76.6" "94.6" "91.2" "73.3" "88.3" "184.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350737749617918576" "False" "High" "IsMasterProtein" "Q5TAQ9" "DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1" "0.000" "False" "20.874" "10" "6" "6" "6" "597" "66.8" "5.39" "17.33" "6" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400" "50717" "ENSG00000132716" "DCAF8" "D3DVE6; hsa:50717; Q12839; Q4QQI6; Q53F14; Q5TAQ9; Q66K50; Q68CS7; Q96E00" "Neddylation" "" "1" "0" "0.987" "0.951" "1.063" "0.961" "0.902" "0.995" "0.973" "0.840" "0.784" "276.4" "272.7" "262.8" "293.9" "265.8" "249.3" "275.0" "268.9" "232.3" "216.6" "" "" "" "" "" "" "" "" "" "" "245.1" "225.9" "229.3" "219.8" "221.6" "229.0" "232.4" "222.3" "213.1" "216.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7379304699154124017" "False" "High" "IsMasterProtein" "Q7Z7C8" "Transcription initiation factor TFIID subunit 8 OS=Homo sapiens OX=9606 GN=TAF8 PE=1 SV=1" "0.000" "False" "20.858" "13" "3" "4" "3" "310" "34.2" "6.46" "17.90" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07524, Pf10406" "129685" "ENSG00000137413" "TAF8" "hsa:129685; Q5T0K1; Q7Z7C8; Q8N4R9; Q96M52" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.938" "0.947" "0.987" "0.920" "0.998" "0.962" "0.910" "0.980" "0.751" "228.7" "214.6" "216.5" "225.8" "210.3" "228.2" "220.0" "208.2" "224.0" "171.8" "" "" "" "" "" "" "" "" "" "" "202.8" "177.7" "188.9" "168.8" "175.4" "209.7" "185.9" "172.1" "205.4" "171.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7069334460136082352" "False" "High" "IsMasterProtein" "Q9Y4P8" "WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1" "0.000" "False" "20.850" "13" "5" "7" "4" "454" "49.4" "6.46" "20.25" "5" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf21032" "26100" "ENSG00000157954" "WIPI2" "B3KNC2; hsa:26100; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; Q9Y4P8" "Macroautophagy" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "6" "1" "0.974" "0.831" "0.990" "0.773" "0.622" "0.820" "0.808" "0.874" "0.600" "721.0" "702.1" "599.2" "713.7" "557.5" "448.6" "591.1" "582.5" "630.5" "432.6" "" "" "" "" "" "" "" "" "" "" "639.4" "581.6" "522.8" "533.8" "464.9" "412.1" "499.5" "481.4" "578.2" "432.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2282593962912776213" "False" "High" "IsMasterProtein" "Q15853" "Upstream stimulatory factor 2 OS=Homo sapiens OX=9606 GN=USF2 PE=1 SV=1" "0.000" "False" "20.840" "12" "4" "5" "3" "346" "36.9" "5.10" "17.46" "4" "transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7392" "ENSG00000105698" "USF2" "hsa:7392; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q15853; Q6FI33; Q6YI47" "Estrogen-dependent gene expression" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "2" "1" "1.068" "1.043" "1.160" "1.028" "1.024" "1.001" "1.028" "1.024" "0.781" "469.1" "500.9" "489.3" "544.1" "482.1" "480.5" "469.6" "482.3" "480.5" "366.5" "" "" "" "" "" "" "" "" "" "" "416.0" "414.9" "427.0" "406.9" "402.0" "441.4" "396.9" "398.6" "440.7" "366.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.000" "False" "20.788" "13" "4" "9" "4" "243" "27.9" "4.20" "30.39" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "Protein hydroxylation" "" "1" "0" "0.902" "0.849" "0.863" "0.742" "0.594" "0.569" "0.833" "0.819" "0.471" "1545.8" "1394.2" "1312.9" "1334.6" "1147.4" "917.9" "879.3" "1287.0" "1266.0" "727.9" "" "" "" "" "" "" "" "" "" "" "1370.8" "1154.9" "1145.6" "998.1" "956.8" "843.2" "743.1" "1063.8" "1161.1" "727.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7795104145569461525" "False" "High" "IsMasterProtein" "Q2M389" "WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2" "0.000" "False" "20.775" "4" "5" "5" "5" "1173" "136.3" "7.44" "16.35" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14744, Pf14745, Pf14746" "23325" "ENSG00000136051" "WASHC4" "hsa:23325; Q2M389; Q2NL83; Q8IW61; Q8N5W7; Q9NVD6; Q9UPW7" "" "" "0" "0" "1.170" "1.118" "1.097" "1.039" "1.202" "1.185" "1.027" "1.216" "5.266" "232.4" "271.9" "259.8" "255.1" "241.4" "279.4" "275.3" "238.7" "282.7" "1224.0" "" "" "" "" "" "" "" "" "" "" "206.1" "225.3" "226.7" "190.8" "201.3" "256.6" "232.7" "197.3" "259.3" "1224.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6162368025994279371" "False" "High" "IsMasterProtein" "Q13395" "Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1" "0.000" "False" "20.774" "3" "5" "5" "5" "1621" "181.6" "7.05" "18.61" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00588" "6894" "ENSG00000059588" "TARBP1" "hsa:6894; Q13395; Q9H581" "" "" "0" "0" "1.117" "0.936" "1.209" "1.070" "1.001" "1.023" "1.008" "0.970" "0.783" "350.6" "391.8" "328.2" "424.1" "375.2" "350.8" "358.7" "353.6" "340.2" "274.6" "" "" "" "" "" "" "" "" "" "" "310.9" "324.5" "286.4" "317.1" "312.9" "322.3" "303.2" "292.2" "312.0" "274.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2516739525907873838" "False" "High" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "0.000" "False" "20.771" "8" "6" "13" "6" "788" "86.7" "9.42" "51.47" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606, Pf21538, Pf21539" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "7" "0" "1.030" "0.986" "1.097" "1.041" "0.993" "1.002" "0.963" "0.911" "1.130" "603.4" "621.6" "594.8" "662.0" "628.0" "599.5" "604.5" "581.0" "550.0" "682.0" "" "" "" "" "" "" "" "" "" "" "535.1" "514.9" "519.0" "495.1" "523.6" "550.7" "510.9" "480.2" "504.4" "682.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.000" "False" "20.756" "25" "5" "7" "5" "206" "21.2" "4.55" "20.58" "5" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "" "TNF-alpha signaling pathway" "1" "0" "1.024" "1.030" "1.128" "1.060" "1.047" "0.961" "0.940" "1.024" "0.799" "874.2" "895.4" "900.2" "985.8" "926.8" "915.4" "840.5" "821.7" "895.0" "698.2" "" "" "" "" "" "" "" "" "" "" "775.2" "741.7" "785.5" "737.2" "772.8" "840.9" "710.3" "679.2" "820.8" "698.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3152037375536322199" "False" "High" "IsMasterProtein" "P68402" "Platelet-activating factor acetylhydrolase IB subunit alpha2 OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1" "0.000" "False" "20.742" "21" "5" "10" "4" "229" "25.6" "5.92" "33.45" "5" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13472" "5049" "ENSG00000168092" "PAFAH1B2" "A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "PAFAH1B1 copy number variation" "3" "1" "0.962" "1.094" "1.018" "1.099" "1.033" "1.042" "0.929" "1.184" "2.178" "558.6" "537.6" "611.1" "568.5" "613.7" "577.0" "582.0" "519.2" "661.3" "1216.7" "" "" "" "" "" "" "" "" "" "" "495.4" "445.3" "533.2" "425.2" "511.7" "530.0" "491.9" "429.2" "606.5" "1216.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357381019356623363" "False" "High" "IsMasterProtein" "Q15025" "TNFAIP3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TNIP1 PE=1 SV=2" "0.000" "False" "20.739" "6" "4" "4" "4" "636" "71.8" "6.62" "14.93" "4" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "10318" "ENSG00000145901" "TNIP1" "A4F1W8; A4F1W9; A4F1X2; A4F1X4; A4F1X5; A4F1X6; A4F1X7; A4F1X9; B7Z699; E7EPY1; E7ET96; hsa:10318; O76008; Q05KP3; Q05KP4; Q15025; Q6N077; Q96EL9; Q99833; Q9H1J3" "Ovarian tumor domain proteases" "RAC1/PAK1/p38/MMP2 pathway" "2" "0" "1.003" "1.018" "1.201" "1.032" "0.958" "0.998" "0.874" "0.950" "2.292" "160.8" "161.3" "163.7" "193.1" "165.9" "154.1" "160.5" "140.6" "152.8" "368.6" "" "" "" "" "" "" "" "" "" "" "142.6" "133.6" "142.8" "144.4" "138.3" "141.5" "135.6" "116.2" "140.2" "368.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8030934540585171981" "False" "High" "IsMasterProtein" "Q9UJT0" "Tubulin epsilon chain OS=Homo sapiens OX=9606 GN=TUBE1 PE=1 SV=1" "0.000" "False" "20.720" "8" "4" "6" "4" "475" "52.9" "6.64" "23.26" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "51175" "ENSG00000074935" "TUBE1" "hsa:51175; Q5H8W8; Q8NEG3; Q9UJT0" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "0.967" "1.012" "1.014" "0.983" "0.944" "0.952" "0.969" "0.979" "0.552" "732.4" "708.4" "741.2" "742.3" "720.0" "691.4" "696.9" "709.7" "717.2" "404.0" "" "" "" "" "" "" "" "" "" "" "649.5" "586.8" "646.8" "555.1" "600.4" "635.1" "589.0" "586.7" "657.7" "404.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8392578490847645683" "False" "High" "IsMasterProtein" "Q9NR33" "DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2" "0.000" "False" "20.682" "18" "2" "4" "2" "117" "12.2" "4.92" "15.83" "2" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "56655" "ENSG00000115350" "POLE4" "Q53TR2; Q9NR33" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Dual Incision in GG-NER; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "16" "0" "0.905" "1.033" "0.784" "0.930" "1.116" "0.928" "1.007" "1.132" "1.287" "507.4" "459.0" "523.9" "397.8" "471.7" "566.2" "470.6" "510.9" "574.2" "653.1" "" "" "" "" "" "" "" "" "" "" "449.9" "380.2" "457.2" "297.5" "393.3" "520.1" "397.8" "422.3" "526.6" "653.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.000" "False" "20.662" "17" "4" "4" "4" "263" "29.4" "10.02" "9.16" "4" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "Neutrophil degranulation" "" "1" "0" "0.935" "0.769" "1.125" "0.815" "0.849" "0.902" "0.815" "0.856" "0.612" "183.2" "171.4" "141.0" "206.2" "149.4" "155.5" "165.3" "149.4" "156.9" "112.2" "" "" "" "" "" "" "" "" "" "" "162.5" "141.9" "123.0" "154.2" "124.5" "142.9" "139.7" "123.5" "143.9" "112.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "796383816243011669" "False" "High" "IsMasterProtein" "O43513" "Mediator of RNA polymerase II transcription subunit 7 OS=Homo sapiens OX=9606 GN=MED7 PE=1 SV=1" "0.000" "False" "20.654" "15" "2" "4" "2" "233" "27.2" "5.78" "15.61" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05983" "9443" "ENSG00000155868" "MED7" "hsa:9443; O43513" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.161" "0.877" "1.472" "1.146" "0.769" "1.304" "0.965" "0.836" "0.694" "103.5" "120.1" "90.7" "152.2" "118.6" "79.5" "134.9" "99.8" "86.5" "71.8" "" "" "" "" "" "" "" "" "" "" "91.7" "99.5" "79.1" "113.9" "98.9" "73.1" "114.0" "82.5" "79.3" "71.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.000" "False" "20.653" "35" "5" "7" "5" "125" "14.5" "10.54" "23.92" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.940" "0.807" "0.900" "0.865" "0.733" "0.646" "0.728" "0.754" "0.788" "606.6" "570.4" "489.6" "546.1" "524.7" "444.5" "392.0" "441.9" "457.3" "478.3" "" "" "" "" "" "" "" "" "" "" "537.9" "472.5" "427.2" "408.4" "437.5" "408.3" "331.3" "365.3" "419.4" "478.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3246576723643333795" "False" "High" "IsMasterProtein" "Q8N668" "COMM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMMD1 PE=1 SV=1" "0.000" "False" "20.631" "23" "4" "9" "3" "190" "21.2" "6.20" "29.85" "4" "DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07258, Pf17221" "150684" "ENSG00000173163" "COMMD1" "B4DFQ4; hsa:150684; Q8N668; Q96GS0" "Neddylation" "Copper homeostasis; 1p36 copy number variation syndrome" "3" "0" "1.003" "0.997" "1.087" "1.069" "1.060" "1.029" "0.948" "0.907" "1.169" "394.8" "396.0" "393.6" "429.2" "422.2" "418.5" "406.5" "374.5" "357.9" "461.5" "" "" "" "" "" "" "" "" "" "" "350.1" "328.1" "343.4" "321.0" "352.1" "384.5" "343.5" "309.5" "328.3" "461.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441805136985848157" "False" "High" "IsMasterProtein" "Q8TB52" "F-box only protein 30 OS=Homo sapiens OX=9606 GN=FBXO30 PE=1 SV=3" "0.000" "False" "20.618" "5" "3" "3" "3" "745" "82.3" "5.40" "12.83" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf15965, Pf15966" "84085" "ENSG00000118496" "FBXO30" "hsa:84085; Q8TB52; Q9BXZ7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.873" "0.713" "0.759" "0.646" "0.628" "0.612" "0.786" "0.900" "0.272" "550.1" "480.4" "392.2" "417.7" "355.1" "345.3" "336.6" "432.4" "495.0" "149.6" "" "" "" "" "" "" "" "" "" "" "487.8" "397.9" "342.2" "312.4" "296.1" "317.2" "284.5" "357.4" "454.0" "149.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8041329701449868553" "False" "High" "IsMasterProtein" "P07864" "L-lactate dehydrogenase C chain OS=Homo sapiens OX=9606 GN=LDHC PE=1 SV=4" "0.000" "False" "20.605" "11" "4" "34" "2" "332" "36.3" "7.46" "110.17" "4" "other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3948" "ENSG00000166796" "LDHC" "D3DQY4; hsa:3948; P07864; Q6GSG8; Q7Z7J4" "Pyruvate metabolism" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8588470506095453677" "False" "High" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "0.000" "False" "20.588" "21" "8" "8" "8" "280" "31.6" "8.76" "23.42" "8" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "1.103" "1.060" "1.115" "1.109" "1.139" "1.056" "1.073" "1.075" "0.714" "252.1" "278.1" "267.2" "281.1" "279.6" "287.1" "266.1" "270.4" "271.1" "180.0" "" "" "" "" "" "" "" "" "" "" "223.5" "230.3" "233.1" "210.3" "233.1" "263.7" "224.9" "223.5" "248.6" "180.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7524617474399668793" "False" "High" "IsMasterProtein" "Q6DD88" "Atlastin-3 OS=Homo sapiens OX=9606 GN=ATL3 PE=1 SV=1" "0.000" "False" "20.578" "9" "5" "6" "5" "541" "60.5" "5.66" "21.25" "5" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf02263, Pf02841" "25923" "ENSG00000184743" "ATL3" "hsa:25923; Q6DD88; Q8N7W5; Q9H8Q5; Q9UFL1" "" "" "0" "0" "1.061" "0.956" "1.110" "1.082" "1.004" "1.181" "1.163" "1.216" "1.543" "209.5" "222.2" "200.2" "232.5" "226.6" "210.3" "247.3" "243.6" "254.8" "323.1" "" "" "" "" "" "" "" "" "" "" "185.7" "184.1" "174.6" "173.9" "188.9" "193.1" "209.0" "201.4" "233.7" "323.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "20.539" "4" "6" "7" "5" "1393" "155.9" "5.62" "17.13" "6" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "" "2" "0" "1.022" "1.028" "0.961" "0.927" "0.987" "1.023" "0.936" "1.015" "2.707" "225.3" "230.2" "231.6" "216.4" "208.8" "222.3" "230.5" "211.0" "228.7" "609.8" "" "" "" "" "" "" "" "" "" "" "199.8" "190.7" "202.1" "161.8" "174.1" "204.2" "194.8" "174.4" "209.7" "609.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2168737288158195697" "False" "High" "IsMasterProtein" "Q9Y2K1" "Zinc finger and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZBTB1 PE=1 SV=3" "0.000" "False" "20.539" "6" "4" "5" "4" "713" "82.0" "6.39" "15.86" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "22890" "ENSG00000126804" "ZBTB1" "A8K6S8; hsa:22890; Q86SW8; Q9Y2K1" "" "" "0" "0" "1.050" "0.985" "0.993" "0.838" "0.746" "0.836" "1.037" "1.075" "1.164" "93.0" "97.6" "91.6" "92.3" "77.9" "69.4" "77.7" "96.4" "100.0" "108.2" "" "" "" "" "" "" "" "" "" "" "82.4" "80.8" "79.9" "69.1" "64.9" "63.7" "65.7" "79.7" "91.7" "108.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841381739766448706" "False" "High" "IsMasterProtein" "Q2M296" "Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2" "0.000" "False" "20.539" "17" "6" "7" "6" "383" "42.1" "8.73" "23.85" "6" "" "other cell component" "" "Pf00076, Pf01812" "64779" "ENSG00000103248" "MTHFSD" "A8MQ77; B7ZLC0; B7ZLC2; D3DUM9; E9PAM1; hsa:64779; Q2M296; Q9H878; Q9H954" "" "" "0" "0" "0.938" "0.990" "0.985" "1.047" "0.936" "1.028" "0.982" "0.848" "0.990" "410.3" "384.8" "406.1" "404.1" "429.7" "384.1" "421.8" "403.0" "348.0" "406.0" "" "" "" "" "" "" "" "" "" "" "363.8" "318.8" "354.3" "302.2" "358.3" "352.8" "356.5" "333.1" "319.2" "406.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4160171774517724011" "False" "High" "IsMasterProtein" "P51452" "Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1" "0.000" "False" "20.513" "28" "4" "5" "4" "185" "20.5" "7.80" "16.64" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00782" "1845" "ENSG00000108861" "DUSP3" "D3DX45; hsa:1845; P51452; Q5U0J1; Q8IYJ9" "ERKs are inactivated" "MAPK signaling pathway; Fragile X syndrome" "3" "0" "1.166" "1.029" "1.165" "1.096" "1.001" "1.033" "1.085" "1.055" "0.944" "176.4" "205.7" "181.5" "205.5" "193.3" "176.5" "182.1" "191.4" "186.0" "166.5" "" "" "" "" "" "" "" "" "" "" "156.4" "170.4" "158.4" "153.7" "161.2" "162.2" "153.9" "158.2" "170.6" "166.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318017659961933117" "False" "High" "IsMasterProtein" "Q9NVA1" "Ubiquinol-cytochrome c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3" "0.000" "False" "20.505" "16" "5" "5" "5" "299" "34.6" "8.91" "19.02" "5" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "" "Pf03981" "55245" "ENSG00000101019" "UQCC1" "B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1" "" "Ciliary landscape; Mitochondrial complex III assembly" "2" "0" "1.022" "0.985" "1.050" "1.069" "1.121" "1.041" "1.131" "0.912" "0.399" "708.5" "724.2" "698.1" "744.0" "757.3" "794.2" "737.7" "801.6" "646.2" "282.9" "" "" "" "" "" "" "" "" "" "" "628.3" "599.9" "609.1" "556.4" "631.5" "729.5" "623.5" "662.6" "592.7" "282.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5690407567518484702" "False" "High" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "0.000" "False" "20.483" "7" "6" "7" "6" "855" "99.9" "6.23" "21.41" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "Rett syndrome; Nucleotide excision repair in xeroderma pigmentosum" "7" "0" "0.939" "0.847" "0.997" "1.007" "1.000" "1.065" "0.887" "1.027" "2.742" "463.9" "435.6" "393.1" "462.4" "467.2" "463.9" "493.9" "411.4" "476.6" "1272.0" "" "" "" "" "" "" "" "" "" "" "411.4" "360.9" "343.0" "345.8" "389.6" "426.1" "417.4" "340.1" "437.1" "1272.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1368746537246451603" "False" "High" "IsMasterProtein" "Q9Y2I8" "WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2" "0.000" "False" "20.476" "10" "5" "5" "5" "494" "54.6" "7.23" "18.50" "5" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "22884" "ENSG00000047056" "WDR37" "A8K976; D3DRQ7; hsa:22884; Q5SW03; Q8WVG2; Q9NTJ6; Q9Y2I8" "" "" "0" "0" "1.086" "1.012" "1.038" "1.018" "0.972" "0.964" "0.918" "0.878" "0.886" "443.5" "481.6" "448.7" "460.3" "451.6" "430.9" "427.7" "407.3" "389.5" "392.9" "" "" "" "" "" "" "" "" "" "" "393.3" "398.9" "391.5" "344.2" "376.6" "395.9" "361.5" "336.7" "357.3" "392.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "High" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.000" "False" "20.475" "3" "5" "5" "5" "1824" "206.7" "6.47" "18.37" "5" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "3" "0" "1.008" "1.041" "0.957" "1.021" "1.043" "0.995" "0.989" "1.108" "1.416" "403.0" "406.3" "419.3" "385.8" "411.3" "420.3" "401.0" "398.6" "446.3" "570.5" "" "" "" "" "" "" "" "" "" "" "357.3" "336.5" "365.9" "288.5" "343.0" "386.1" "338.9" "329.5" "409.3" "570.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5624599927589214595" "False" "High" "IsMasterProtein" "Q3B7J2" "Glucose-fructose oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GFOD2 PE=1 SV=1" "0.000" "False" "20.472" "13" "5" "5" "5" "385" "42.2" "6.44" "18.20" "5" "cell organization and biogenesis" "non-structural extracellular;extracellular matrix" "other molecular function" "Pf01408" "81577" "ENSG00000141098" "GFOD2" "hsa:81577; Q3B7J2; Q69YL9; Q6UXX6; Q7L648; Q8TE86; Q9BQ07; R4GNG5" "" "" "0" "0" "1.202" "1.089" "1.225" "1.132" "1.201" "1.177" "1.124" "1.063" "1.101" "400.6" "481.6" "436.1" "490.7" "453.6" "481.0" "471.4" "450.2" "426.0" "440.9" "" "" "" "" "" "" "" "" "" "" "355.2" "398.9" "380.5" "367.0" "378.2" "441.8" "398.4" "372.1" "390.7" "440.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "High" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.000" "False" "20.455" "3" "5" "6" "4" "1440" "159.4" "6.14" "18.89" "5" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "0.946" "0.989" "0.989" "0.894" "0.856" "0.973" "0.954" "0.897" "0.654" "204.5" "193.4" "202.1" "202.3" "182.9" "175.0" "198.9" "195.0" "183.4" "133.7" "" "" "" "" "" "" "" "" "" "" "181.3" "160.2" "176.4" "151.3" "152.5" "160.8" "168.1" "161.2" "168.2" "133.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2364171353668644168" "False" "High" "IsMasterProtein" "Q00653" "Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4" "0.000" "False" "20.442" "7" "6" "7" "5" "900" "96.7" "6.25" "21.52" "6" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4791" "ENSG00000077150" "NFKB2" "A8K9D9; D3DR83; hsa:4791; Q00653; Q04860; Q9BU75; Q9H471; Q9H472" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; Interleukin-1 processing; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus infection in host; Breast cancer pathway; Acute viral myocarditis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "43" "0" "1.192" "1.109" "1.133" "0.993" "0.887" "1.029" "0.672" "0.987" "7.385" "192.3" "229.2" "213.3" "217.8" "191.0" "170.6" "197.9" "129.2" "189.8" "1420.2" "" "" "" "" "" "" "" "" "" "" "170.5" "189.9" "186.1" "162.9" "159.2" "156.8" "167.3" "106.8" "174.0" "1420.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182186368676627238" "False" "High" "IsMasterProtein" "Q13405" "Large ribosomal subunit protein mL49 OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" "0.000" "False" "20.424" "32" "5" "8" "5" "166" "19.2" "9.45" "27.87" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05046" "740" "ENSG00000149792" "MRPL49" "B2R4G6; hsa:740; Q13405" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.008" "0.912" "0.973" "0.965" "0.991" "0.929" "0.883" "0.963" "0.869" "792.9" "799.5" "723.3" "771.5" "765.1" "785.7" "736.3" "700.4" "763.6" "689.4" "" "" "" "" "" "" "" "" "" "" "703.1" "662.2" "631.1" "577.0" "638.0" "721.7" "622.3" "578.9" "700.3" "689.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2029862218257081345" "False" "High" "IsMasterProtein" "O15318" "DNA-directed RNA polymerase III subunit RPC7 OS=Homo sapiens OX=9606 GN=POLR3G PE=1 SV=2" "0.000" "False" "20.367" "11" "2" "7" "2" "223" "25.9" "4.63" "29.00" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf11705" "10622" "ENSG00000113356" "POLR3G" "A8MTH0; hsa:10622; O15318" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "10" "0" "1.016" "0.935" "1.003" "1.006" "1.038" "1.056" "1.069" "1.032" "0.828" "575.0" "584.1" "537.6" "576.9" "578.8" "597.0" "607.4" "614.8" "593.3" "476.3" "" "" "" "" "" "" "" "" "" "" "509.9" "483.9" "469.1" "431.5" "482.6" "548.4" "513.3" "508.2" "544.1" "476.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "High" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.000" "False" "20.362" "9" "7" "7" "7" "653" "73.4" "4.75" "21.00" "7" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "3" "0" "0.932" "0.931" "1.009" "0.874" "0.848" "0.899" "0.907" "0.845" "0.666" "474.7" "442.3" "441.9" "479.0" "415.1" "402.8" "426.6" "430.4" "400.9" "316.0" "" "" "" "" "" "" "" "" "" "" "421.0" "366.4" "385.6" "358.2" "346.1" "370.0" "360.5" "355.8" "367.7" "316.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5232175681869918932" "False" "High" "IsMasterProtein" "Q14678" "KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KANK1 PE=1 SV=3" "0.000" "False" "20.356" "3" "3" "3" "3" "1352" "147.2" "5.30" "12.97" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00023, Pf12075" "23189" "ENSG00000107104" "KANK1" "A2A2W8; D3DRH3; hsa:23189; Q14678; Q5W0W0; Q8IY65; Q8WX74" "Estrogen-dependent gene expression; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "VEGFA-VEGFR2 signaling" "3" "0" "1.107" "1.155" "1.074" "1.087" "1.104" "1.009" "0.664" "1.002" "6.706" "180.6" "199.9" "208.6" "194.0" "196.4" "199.5" "182.3" "119.9" "181.0" "1211.3" "" "" "" "" "" "" "" "" "" "" "160.2" "165.6" "182.0" "145.1" "163.8" "183.2" "154.1" "99.1" "166.0" "1211.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6373190460563601224" "False" "High" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "0.000" "False" "20.311" "5" "5" "6" "4" "1031" "117.3" "9.29" "17.91" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "mRNA Splicing - Major Pathway" "" "1" "0" "1.169" "1.127" "1.121" "0.994" "1.023" "1.166" "0.963" "1.044" "5.270" "102.2" "119.5" "115.2" "114.6" "101.6" "104.6" "119.2" "98.4" "106.7" "538.7" "" "" "" "" "" "" "" "" "" "" "90.6" "99.0" "100.6" "85.7" "84.7" "96.1" "100.8" "81.4" "97.9" "538.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "High" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.000" "False" "20.299" "4" "5" "5" "5" "1274" "141.1" "6.13" "14.41" "5" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "" "5" "0" "1.058" "0.913" "0.986" "0.895" "0.835" "0.956" "0.742" "0.838" "3.519" "93.9" "99.4" "85.8" "92.6" "84.1" "78.4" "89.8" "69.7" "78.7" "330.6" "" "" "" "" "" "" "" "" "" "" "83.3" "82.4" "74.9" "69.3" "70.1" "72.1" "75.9" "57.6" "72.2" "330.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8760192209186557782" "False" "High" "IsMasterProtein" "Q8NCA5" "Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2" "0.000" "False" "20.281" "7" "2" "3" "2" "518" "55.2" "8.95" "17.50" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "25940" "ENSG00000119812" "FAM98A" "B2RNA2; hsa:25940; Q8NCA5; Q9Y3Y6" "" "" "0" "0" "0.889" "0.868" "0.902" "0.788" "0.824" "0.696" "0.761" "0.760" "0.950" "181.5" "161.3" "157.6" "163.7" "143.1" "149.6" "126.4" "138.1" "138.0" "172.4" "" "" "" "" "" "" "" "" "" "" "161.0" "133.6" "137.5" "122.4" "119.3" "137.4" "106.8" "114.2" "126.5" "172.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5312560653861073020" "False" "High" "IsMasterProtein" "P82932" "Small ribosomal subunit protein bS6m OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3" "0.000" "False" "20.237" "39" "5" "6" "5" "125" "14.2" "9.26" "21.41" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01250" "64968" "ENSG00000243927" "MRPS6" "B2R573; hsa:64968; P82932; Q96Q64; Q9BSK8; Q9BW89" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.883" "0.901" "0.925" "0.926" "0.926" "0.972" "0.856" "0.906" "1.649" "865.9" "764.4" "780.4" "800.7" "801.6" "801.7" "841.4" "741.0" "784.1" "1428.2" "" "" "" "" "" "" "" "" "" "" "767.9" "633.2" "681.0" "598.8" "668.4" "736.4" "711.1" "612.4" "719.1" "1428.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5085231935458707065" "False" "High" "IsMasterProtein" "O75530" "Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2" "0.000" "False" "20.219" "15" "7" "7" "7" "441" "50.2" "7.03" "21.15" "7" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "8726" "ENSG00000074266" "EED" "A8K7V5; hsa:8726; O00149; O75530; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7" "HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; 5q35 copy number variation" "15" "0" "1.053" "1.032" "1.066" "1.019" "1.013" "0.970" "0.912" "0.961" "2.675" "593.9" "625.2" "613.2" "633.0" "605.5" "601.8" "576.2" "541.7" "570.8" "1588.6" "" "" "" "" "" "" "" "" "" "" "526.7" "517.9" "535.0" "473.4" "504.9" "552.8" "487.0" "447.7" "523.5" "1588.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.000" "False" "20.199" "38" "4" "6" "4" "107" "12.1" "9.64" "20.74" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.937" "0.990" "1.025" "1.010" "0.992" "0.995" "1.044" "0.956" "0.538" "667.6" "625.8" "661.2" "684.1" "674.5" "662.2" "664.1" "696.9" "638.5" "359.4" "" "" "" "" "" "" "" "" "" "" "592.0" "518.4" "577.0" "511.6" "562.4" "608.3" "561.3" "576.0" "585.6" "359.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120451514636770754" "False" "High" "IsMasterProtein" "Q12979" "Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2" "0.000" "False" "20.187" "7" "6" "6" "6" "859" "97.5" "6.55" "21.75" "6" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00168, Pf00620, Pf00621" "29" "ENSG00000159842; ENSG00000276016; ENSG00000278741" "ABR" "B3KW89; B7Z6H7; D3DTH3; D3DTH4; F5H3S2; F5H8B3; hsa:29; Q12979; Q13693; Q13694" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle" "" "9" "0" "1.157" "0.964" "1.011" "0.933" "0.968" "1.042" "0.537" "0.972" "8.500" "435.3" "503.6" "419.6" "440.0" "406.1" "421.5" "453.6" "233.9" "423.2" "3700.1" "" "" "" "" "" "" "" "" "" "" "386.0" "417.2" "366.1" "329.1" "338.6" "387.2" "383.4" "193.3" "388.2" "3700.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.000" "False" "20.162" "25" "3" "5" "3" "150" "17.4" "5.67" "25.01" "3" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "1.077" "1.055" "1.040" "1.079" "1.127" "1.082" "1.124" "0.995" "0.756" "859.0" "925.2" "906.4" "893.6" "926.7" "968.3" "929.8" "965.7" "854.5" "649.0" "" "" "" "" "" "" "" "" "" "" "761.8" "766.4" "790.9" "668.3" "772.7" "889.5" "785.8" "798.2" "783.7" "649.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.000" "False" "20.154" "27" "4" "7" "4" "184" "20.1" "4.18" "26.93" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "RMTs methylate histone arginines" "NF1 copy number variation syndrome" "2" "0" "0.978" "0.899" "1.005" "0.935" "0.961" "1.088" "1.099" "1.083" "0.518" "676.3" "661.3" "607.7" "679.4" "632.1" "650.2" "736.1" "743.4" "732.2" "350.1" "" "" "" "" "" "" "" "" "" "" "599.7" "547.8" "530.2" "508.1" "527.1" "597.3" "622.1" "614.5" "671.5" "350.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394977433117342737" "False" "High" "IsMasterProtein" "Q92859" "Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 SV=2" "0.000" "False" "20.104" "3" "4" "4" "4" "1461" "159.9" "6.54" "16.40" "4" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf06583, Pf07679, Pf13895, Pf13927" "4756" "ENSG00000067141" "NEO1" "B7ZKM9; B7ZKN0; hsa:4756; O00340; Q17RX1; Q92859" "Myogenesis; Netrin-1 signaling" "Splicing factor NOVA regulated synaptic proteins; Netrin-UNC5B signaling pathway; 10q11.21q11.23 copy number variation syndrome" "5" "0" "0.906" "0.945" "0.893" "0.865" "0.836" "0.944" "0.955" "0.891" "0.657" "169.5" "153.5" "160.3" "151.4" "146.6" "141.7" "160.0" "161.9" "151.1" "111.4" "" "" "" "" "" "" "" "" "" "" "150.3" "127.2" "139.9" "113.2" "122.3" "130.2" "135.2" "133.9" "138.6" "111.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4156627100779081460" "False" "High" "IsMasterProtein" "Q02446" "Transcription factor Sp4 OS=Homo sapiens OX=9606 GN=SP4 PE=1 SV=2" "0.000" "False" "20.101" "10" "6" "6" "6" "784" "81.9" "7.05" "18.52" "6" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6671" "ENSG00000105866" "SP4" "hsa:6671; O60402; Q02446; Q32M52" "" "" "0" "0" "0.871" "0.978" "0.856" "0.861" "0.764" "0.843" "0.969" "1.210" "0.471" "790.8" "689.1" "773.8" "676.8" "680.8" "604.1" "666.5" "766.0" "956.8" "372.2" "" "" "" "" "" "" "" "" "" "" "701.3" "570.8" "675.2" "506.2" "567.7" "555.0" "563.3" "633.1" "877.5" "372.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1354238916064112101" "False" "High" "IsMasterProtein" "Q5T6V5" "Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Homo sapiens OX=9606 GN=QNG1 PE=1 SV=1" "0.000" "False" "20.061" "19" "7" "8" "7" "341" "39.0" "5.88" "25.41" "7" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf10343" "84267" "ENSG00000165118" "QNG1" "B2RPI6; hsa:84267; Q5T6V5; Q8N2B1; Q9BT18" "" "" "0" "0" "1.084" "0.787" "1.201" "1.461" "0.804" "4.570" "0.675" "0.762" "7.159" "119.0" "129.0" "93.7" "142.8" "173.8" "95.6" "543.6" "80.3" "90.7" "851.6" "" "" "" "" "" "" "" "" "" "" "105.5" "106.9" "81.7" "106.8" "144.9" "87.8" "459.5" "66.4" "83.1" "851.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032311727132364318" "False" "High" "IsMasterProtein" "Q8IVV7" "Glucose-induced degradation protein 4 homolog OS=Homo sapiens OX=9606 GN=GID4 PE=1 SV=1" "0.000" "False" "20.051" "7" "2" "3" "2" "300" "33.5" "9.16" "12.34" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf09783" "79018" "ENSG00000141034" "GID4" "hsa:79018; Q8IVV7; Q8TEB5; Q9BW50" "" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.032" "0.932" "1.103" "0.999" "1.032" "0.995" "0.946" "0.979" "1.221" "397.5" "410.2" "370.4" "438.4" "397.0" "410.3" "395.3" "375.9" "389.3" "485.2" "" "" "" "" "" "" "" "" "" "" "352.5" "339.8" "323.2" "327.9" "331.0" "376.9" "334.1" "310.7" "357.0" "485.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-448736336253279631" "False" "High" "IsMasterProtein" "Q9Y2H0" "Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4 PE=1 SV=3" "0.000" "False" "20.033" "5" "3" "3" "3" "992" "107.9" "7.08" "13.84" "3" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "22839" "ENSG00000080845" "DLGAP4" "E1P5T5; hsa:22839; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; Q9Y2H0" "Neurexins and neuroligins" "" "1" "0" "1.052" "0.858" "1.156" "1.028" "1.108" "1.004" "1.126" "0.901" "0.556" "110.5" "116.2" "94.9" "127.8" "113.6" "122.5" "110.9" "124.5" "99.6" "61.4" "" "" "" "" "" "" "" "" "" "" "98.0" "96.3" "82.8" "95.6" "94.7" "112.5" "93.8" "102.9" "91.4" "61.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "20.028" "12" "3" "3" "3" "356" "40.5" "8.34" "14.70" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "0.845" "0.881" "0.945" "0.968" "0.969" "1.349" "1.288" "1.329" "3.131" "129.3" "109.3" "113.9" "122.1" "125.1" "125.2" "174.4" "166.4" "171.8" "404.7" "" "" "" "" "" "" "" "" "" "" "114.6" "90.5" "99.4" "91.3" "104.4" "115.0" "147.4" "137.6" "157.5" "404.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "19.995" "8" "6" "6" "6" "661" "72.1" "6.16" "18.71" "6" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "" "Ciliary landscape" "1" "0" "0.991" "0.919" "0.978" "0.948" "0.951" "0.903" "0.954" "0.908" "1.117" "1196.5" "1185.7" "1099.6" "1169.8" "1133.8" "1138.4" "1080.7" "1141.2" "1086.1" "1336.1" "" "" "" "" "" "" "" "" "" "" "1061.1" "982.2" "959.5" "874.8" "945.4" "1045.7" "913.4" "943.3" "996.1" "1336.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080832168399393297" "False" "High" "IsMasterProtein" "Q9Y6D6" "Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2" "0.000" "False" "19.977" "3" "5" "6" "5" "1849" "208.6" "5.85" "16.23" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10565" "ENSG00000066777" "ARFGEF1" "hsa:10565; Q9NV46; Q9UFV2; Q9UNL0; Q9Y6D6" "" "" "0" "0" "0.916" "0.766" "0.876" "0.785" "0.777" "1.001" "0.665" "0.947" "4.929" "155.7" "142.7" "119.3" "136.5" "122.3" "121.0" "155.9" "103.6" "147.4" "767.7" "" "" "" "" "" "" "" "" "" "" "138.1" "118.2" "104.1" "102.1" "102.0" "111.1" "131.7" "85.6" "135.2" "767.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "983128830238586266" "False" "High" "IsMasterProtein" "Q53F19" "Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2" "0.000" "False" "19.927" "6" "4" "4" "4" "620" "70.5" "5.73" "14.99" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10309" "55421" "ENSG00000074356" "NCBP3" "B3KWG7; hsa:55421; Q53F19; Q7L406; Q96FK1; Q9NXZ4" "" "" "0" "0" "1.041" "0.917" "1.028" "1.113" "1.063" "0.920" "0.904" "0.872" "2.729" "82.9" "86.2" "76.0" "85.2" "92.2" "88.1" "76.3" "74.9" "72.2" "226.1" "" "" "" "" "" "" "" "" "" "" "73.5" "71.4" "66.3" "63.7" "76.9" "80.9" "64.4" "61.9" "66.3" "226.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6857356928160301149" "False" "High" "IsMasterProtein" "Q9C0E8" "Endoplasmic reticulum junction formation protein lunapark OS=Homo sapiens OX=9606 GN=LNPK PE=1 SV=2" "0.000" "False" "19.899" "13" "5" "5" "5" "428" "47.7" "5.11" "18.92" "5" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf10058" "80856" "ENSG00000144320" "LNPK" "B7ZLA8; hsa:80856; Q2M2V8; Q2YD99; Q658W8; Q8N5V9; Q96MS5; Q9C0E8" "" "" "0" "0" "1.021" "0.979" "1.092" "1.125" "1.070" "1.008" "1.050" "1.034" "0.534" "585.7" "597.8" "573.3" "639.4" "658.9" "626.9" "590.6" "615.1" "605.8" "312.7" "" "" "" "" "" "" "" "" "" "" "519.4" "495.2" "500.3" "478.2" "549.5" "575.9" "499.2" "508.4" "555.6" "312.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8131199086290691075" "False" "High" "IsMasterProtein" "Q7Z6B7" "SLIT-ROBO Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=SRGAP1 PE=1 SV=1" "0.000" "False" "19.884" "4" "5" "6" "3" "1085" "124.2" "6.83" "19.54" "5" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00018, Pf00611, Pf00620" "57522" "ENSG00000196935" "SRGAP1" "hsa:57522; Q7Z6B7; Q9H8A3; Q9P2P2" "RHOA GTPase cycle; RAC1 GTPase cycle; CDC42 GTPase cycle; Inactivation of CDC42 and RAC1" "" "4" "0" "0.955" "0.910" "0.911" "0.854" "0.858" "0.815" "0.808" "0.867" "1.335" "231.2" "220.7" "210.4" "210.5" "197.4" "198.3" "188.3" "186.7" "200.4" "308.7" "" "" "" "" "" "" "" "" "" "" "205.0" "182.8" "183.5" "157.5" "164.6" "182.2" "159.2" "154.4" "183.8" "308.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "19.872" "10" "6" "7" "6" "577" "63.1" "9.44" "23.07" "6" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "0.954" "1.004" "1.189" "0.886" "0.862" "1.048" "0.926" "1.017" "0.914" "177.2" "169.0" "177.8" "210.6" "157.0" "152.7" "185.7" "164.1" "180.1" "162.0" "" "" "" "" "" "" "" "" "" "" "157.1" "140.0" "155.2" "157.5" "131.0" "140.3" "157.0" "135.6" "165.2" "162.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781078747776304120" "False" "High" "IsMasterProtein" "Q9NY12" "H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1" "0.000" "False" "19.822" "13" "3" "5" "3" "217" "22.3" "10.92" "19.27" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf04410" "54433" "ENSG00000109534" "GAR1" "hsa:54433; Q5MJQ2; Q9NY12" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "0.941" "0.817" "0.869" "0.921" "0.800" "0.911" "0.755" "0.865" "1.278" "308.7" "290.6" "252.1" "268.3" "284.4" "246.8" "281.1" "233.1" "267.1" "394.4" "" "" "" "" "" "" "" "" "" "" "273.7" "240.7" "220.0" "200.7" "237.2" "226.7" "237.6" "192.6" "244.9" "394.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.000" "False" "19.801" "28" "5" "6" "5" "185" "21.4" "5.44" "18.46" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "Unwinding of DNA" "" "1" "0" "1.000" "0.941" "1.071" "0.971" "0.934" "1.023" "1.081" "1.042" "1.735" "395.1" "395.1" "371.9" "423.0" "383.6" "369.2" "404.3" "427.3" "411.5" "685.5" "" "" "" "" "" "" "" "" "" "" "350.4" "327.3" "324.5" "316.4" "319.9" "339.1" "341.7" "353.2" "377.4" "685.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1566902771694482530" "False" "High" "IsMasterProtein" "P51153" "Ras-related protein Rab-13 OS=Homo sapiens OX=9606 GN=RAB13 PE=1 SV=1" "0.000" "False" "19.792" "18" "4" "10" "2" "203" "22.8" "9.19" "30.79" "4" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5872" "ENSG00000143545" "RAB13" "A8K6B5; D3DV67; hsa:5872; P51153; Q5U0A6; Q6GPG6; Q96GU4" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane" "Leukocyte-intrinsic Hippo pathway functions" "4" "0" "0.984" "0.982" "1.126" "1.023" "1.209" "1.050" "0.882" "0.933" "0.786" "165.0" "162.3" "162.0" "185.8" "168.8" "199.6" "173.3" "145.5" "153.9" "129.7" "" "" "" "" "" "" "" "" "" "" "146.3" "134.5" "141.3" "139.0" "140.7" "183.3" "146.5" "120.3" "141.2" "129.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "High" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.000" "False" "19.785" "6" "4" "4" "4" "673" "75.5" "6.73" "13.44" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Neutrophil degranulation" "Ciliary landscape" "2" "0" "0.965" "0.937" "1.046" "0.949" "0.811" "0.967" "0.898" "0.800" "1.241" "178.7" "172.5" "167.4" "187.0" "169.6" "144.9" "172.9" "160.6" "143.1" "221.8" "" "" "" "" "" "" "" "" "" "" "158.5" "142.9" "146.1" "139.9" "141.5" "133.1" "146.1" "132.7" "131.2" "221.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4607067536077994881" "False" "High" "IsMasterProtein" "Q9Y6H1" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CHCHD2 PE=1 SV=1" "0.000" "False" "19.781" "15" "2" "6" "2" "151" "15.5" "9.22" "25.30" "2" "cell organization and biogenesis;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf06747" "51142" "ENSG00000106153" "CHCHD2" "hsa:51142; Q498C3; Q6NZ50; Q9Y6H1" "Mitochondrial protein degradation; Mitochondrial protein import" "Genetic causes of porto-sinusoidal vascular disease" "3" "0" "0.961" "1.074" "1.005" "1.080" "1.050" "1.058" "1.067" "1.084" "0.454" "571.8" "549.6" "614.3" "574.5" "617.5" "600.4" "605.0" "610.2" "619.7" "259.3" "" "" "" "" "" "" "" "" "" "" "507.0" "455.3" "536.0" "429.7" "514.9" "551.5" "511.3" "504.4" "568.4" "259.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8564322409184755345" "False" "High" "IsMasterProtein" "Q9Y4K3" "TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1" "0.000" "False" "19.762" "9" "4" "5" "4" "522" "59.5" "6.44" "16.75" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf13923, Pf18048, Pf21355" "7189" "ENSG00000175104" "TRAF6" "A6NKI7; A8KAB3; D3DR16; hsa:7189; Q8NEH5; Q9Y4K3" "Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PIP3 activates AKT signaling; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Clock-controlled autophagy in bone metabolism; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "78" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1093508448380632282" "False" "High" "IsMasterProtein" "Q9Y3L5" "Ras-related protein Rap-2c OS=Homo sapiens OX=9606 GN=RAP2C PE=1 SV=1" "0.000" "False" "19.746" "21" "4" "6" "4" "183" "20.7" "4.94" "20.10" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57826" "ENSG00000123728" "RAP2C" "B3KWD6; hsa:57826; Q5H9H9; Q9BTS0; Q9Y3L5" "Neutrophil degranulation" "" "1" "0" "1.051" "0.992" "1.141" "1.135" "1.045" "0.935" "1.132" "0.968" "0.693" "392.9" "413.1" "389.7" "448.3" "445.9" "410.5" "367.5" "444.9" "380.2" "272.3" "" "" "" "" "" "" "" "" "" "" "348.4" "342.2" "340.0" "335.3" "371.8" "377.0" "310.6" "367.8" "348.7" "272.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1131809670189224217" "False" "High" "IsMasterProtein" "Q96EY7" "Small ribosomal subunit protein mS39 OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "0.000" "False" "19.741" "6" "4" "4" "4" "689" "78.5" "6.42" "13.11" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.009" "0.927" "1.139" "0.960" "0.923" "1.016" "0.675" "0.911" "5.797" "290.9" "293.6" "269.7" "331.4" "279.4" "268.5" "295.7" "196.3" "265.0" "1686.6" "" "" "" "" "" "" "" "" "" "" "258.0" "243.2" "235.3" "247.8" "232.9" "246.6" "249.9" "162.3" "243.0" "1686.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527140061799616806" "False" "High" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "0.000" "False" "19.711" "11" "6" "6" "6" "673" "73.7" "8.98" "19.11" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "" "2" "0" "0.863" "0.864" "1.052" "0.683" "0.771" "0.727" "0.622" "0.757" "5.164" "131.2" "113.2" "113.3" "137.9" "89.6" "101.1" "95.4" "81.6" "99.3" "677.5" "" "" "" "" "" "" "" "" "" "" "116.3" "93.7" "98.8" "103.2" "74.7" "92.9" "80.6" "67.4" "91.1" "677.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6883874888390724890" "False" "High" "IsMasterProtein" "Q5VTL8" "Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1" "0.000" "False" "19.702" "7" "4" "4" "4" "546" "64.4" "10.54" "13.56" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371" "55119" "ENSG00000134186" "PRPF38B" "hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40" "" "" "0" "0" "1.034" "0.960" "1.100" "0.997" "0.883" "1.201" "1.051" "1.129" "1.628" "560.3" "579.3" "537.8" "616.2" "558.8" "494.5" "673.0" "588.9" "632.5" "912.0" "" "" "" "" "" "" "" "" "" "" "496.9" "479.9" "469.3" "460.8" "466.0" "454.3" "568.8" "486.8" "580.1" "912.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "19.688" "7" "4" "7" "2" "508" "55.0" "7.06" "25.63" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "EGF/EGFR signaling pathway" "8" "2" "1.053" "1.032" "0.921" "0.979" "0.997" "0.929" "0.994" "0.978" "0.885" "818.7" "862.0" "844.5" "753.7" "801.2" "816.4" "760.2" "814.1" "800.5" "724.2" "" "" "" "" "" "" "" "" "" "" "726.0" "714.1" "736.9" "563.7" "668.1" "750.0" "642.5" "672.9" "734.2" "724.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4224605817431316350" "False" "High" "IsMasterProtein" "Q96ST2" "Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2" "0.000" "False" "19.679" "6" "4" "4" "4" "819" "91.9" "4.69" "15.54" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "" "Pf08711" "55677" "ENSG00000163166" "IWS1" "hsa:55677; Q2TB65; Q6P157; Q8N3E8; Q96MI7; Q96ST2; Q9NV97; Q9NWH8" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "1.042" "0.938" "1.050" "0.892" "0.990" "0.871" "0.871" "0.893" "1.324" "315.4" "328.7" "295.7" "331.0" "281.3" "312.2" "274.7" "274.8" "281.6" "417.4" "" "" "" "" "" "" "" "" "" "" "279.7" "272.3" "258.0" "247.5" "234.5" "286.8" "232.2" "227.1" "258.3" "417.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6543857744544751788" "False" "High" "IsMasterProtein" "P38571" "Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo sapiens OX=9606 GN=LIPA PE=1 SV=2" "0.000" "False" "19.660" "9" "4" "6" "4" "399" "45.4" "6.92" "21.49" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00561" "3988" "ENSG00000107798" "LIPA" "B2RBH5; D3DR29; hsa:3988; P38571; Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0" "LDL clearance" "Phase I biotransformations, non-P450; Degradation pathway of sphingolipids, including diseases; Cholesterol metabolism" "4" "0" "1.054" "1.039" "1.115" "1.111" "1.113" "1.168" "1.160" "1.030" "0.555" "599.1" "631.4" "622.6" "668.3" "665.9" "666.7" "700.0" "695.2" "616.9" "332.5" "" "" "" "" "" "" "" "" "" "" "531.3" "523.0" "543.2" "499.8" "555.3" "612.4" "591.6" "574.6" "565.8" "332.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6631585726403495176" "False" "High" "IsMasterProtein" "O14787" "Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3" "0.000" "False" "19.623" "5" "5" "5" "1" "897" "101.3" "5.01" "17.64" "5" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810" "30000" "ENSG00000105576" "TNPO2" "hsa:30000; O14655; O14787; Q6IN77" "" "" "0" "0" "0.987" "1.010" "0.841" "1.054" "0.985" "0.828" "0.252" "1.111" "13.792" "29.1" "28.7" "29.4" "24.5" "30.7" "28.7" "24.1" "7.3" "32.3" "401.6" "" "" "" "" "" "" "" "" "" "" "25.8" "23.8" "25.7" "18.3" "25.6" "26.3" "20.4" "6.1" "29.7" "401.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8501069546997546105" "False" "High" "IsMasterProtein" "Q8WYQ3" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD10 PE=1 SV=1" "0.000" "False" "19.609" "23" "2" "8" "2" "142" "14.1" "7.84" "29.32" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf06747" "400916" "ENSG00000250479; ENSG00000273607" "CHCHD10" "A8K0J5; hsa:400916; Q8WYQ3" "Mitochondrial protein import" "" "1" "0" "0.992" "1.058" "1.007" "1.053" "1.084" "1.054" "0.958" "0.990" "0.663" "566.2" "561.6" "598.9" "570.0" "596.4" "613.5" "596.5" "542.3" "560.7" "375.3" "" "" "" "" "" "" "" "" "" "" "502.1" "465.2" "522.5" "426.3" "497.3" "563.6" "504.2" "448.2" "514.2" "375.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703205907594076097" "False" "High" "IsMasterProtein" "Q12982" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1" "0.000" "False" "19.602" "13" "5" "7" "5" "314" "36.0" "4.81" "25.24" "5" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12496, Pf13716" "663" "ENSG00000140299" "BNIP2" "B4DS94; hsa:663; Q12982" "Myogenesis" "Acute viral myocarditis" "2" "0" "1.078" "1.070" "1.077" "1.055" "1.143" "0.981" "1.011" "0.891" "0.770" "874.2" "942.2" "935.8" "941.7" "922.6" "999.0" "857.4" "883.6" "778.6" "673.1" "" "" "" "" "" "" "" "" "" "" "775.3" "780.5" "816.6" "704.2" "769.3" "917.7" "724.6" "730.4" "714.1" "673.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "19.589" "14" "7" "9" "4" "437" "48.9" "7.80" "26.45" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "Ebola virus infection in host; Ciliary landscape" "6" "0" "0.947" "0.897" "0.926" "0.987" "1.018" "0.969" "0.809" "0.922" "5.264" "224.7" "212.7" "201.6" "208.1" "221.7" "228.6" "217.6" "181.8" "207.2" "1182.6" "" "" "" "" "" "" "" "" "" "" "199.2" "176.2" "175.9" "155.6" "184.8" "210.0" "183.9" "150.3" "190.1" "1182.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7918333957511705273" "False" "High" "IsMasterProtein" "Q68D20" "Protein PMS2CL OS=Homo sapiens OX=9606 GN=PMS2CL PE=1 SV=1" "0.000" "False" "19.587" "27" "3" "5" "3" "193" "20.9" "5.34" "15.95" "3" "" "" "" "" "" "" "PMS2CL" "B4DK88; Q68D20; Q764P1" "" "" "0" "0" "1.054" "0.866" "1.103" "1.081" "1.167" "1.052" "1.154" "0.984" "0.516" "84.2" "88.7" "72.9" "92.8" "91.0" "98.3" "88.6" "97.2" "82.8" "43.4" "" "" "" "" "" "" "" "" "" "" "74.7" "73.5" "63.6" "69.4" "75.9" "90.3" "74.9" "80.3" "76.0" "43.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2426290475951573984" "False" "High" "IsMasterProtein" "Q8WZ73" "E3 ubiquitin-protein ligase rififylin OS=Homo sapiens OX=9606 GN=RFFL PE=1 SV=1" "0.000" "False" "19.536" "13" "4" "5" "4" "363" "40.5" "5.48" "17.24" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13920, Pf21272" "117584" "ENSG00000092871" "RFFL" "E1P633; Q8NHW0; Q8TBY7; Q8WZ73; Q96BE6" "Regulation of TP53 Degradation" "TNF-alpha signaling pathway; 17q12 copy number variation syndrome" "3" "0" "0.990" "0.972" "0.869" "0.971" "1.040" "0.975" "0.944" "0.985" "0.612" "583.8" "578.2" "567.3" "507.2" "566.8" "607.4" "569.1" "551.1" "574.8" "357.3" "" "" "" "" "" "" "" "" "" "" "517.7" "479.0" "495.0" "379.3" "472.7" "558.0" "481.0" "455.5" "527.2" "357.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "19.534" "22" "4" "5" "2" "193" "21.4" "8.53" "14.86" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Separation of Sister Chromatids; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "23" "2" "0.995" "1.014" "0.966" "0.933" "0.903" "0.958" "0.761" "0.923" "6.130" "366.3" "364.4" "371.4" "353.8" "341.6" "330.8" "350.8" "278.6" "338.2" "2245.3" "" "" "" "" "" "" "" "" "" "" "324.8" "301.9" "324.1" "264.6" "284.8" "303.9" "296.4" "230.3" "310.2" "2245.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1992212741193317441" "False" "High" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "0.000" "False" "19.532" "13" "5" "7" "2" "344" "39.6" "11.43" "20.60" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "mRNA processing" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657566489845177469" "False" "High" "IsMasterProtein" "Q969K3" "E3 ubiquitin-protein ligase RNF34 OS=Homo sapiens OX=9606 GN=RNF34 PE=1 SV=1" "0.000" "False" "19.510" "13" "4" "4" "4" "372" "41.6" "4.96" "13.48" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13920, Pf21272" "80196" "ENSG00000170633" "RNF34" "B7Z933; hsa:80196; Q8NG47; Q969K3; Q9H6W8" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TP53 Degradation" "" "2" "0" "1.095" "0.962" "1.141" "1.044" "0.925" "0.960" "0.861" "1.063" "1.525" "108.9" "119.2" "104.8" "124.3" "113.7" "100.7" "104.5" "93.8" "115.7" "166.1" "" "" "" "" "" "" "" "" "" "" "96.6" "98.8" "91.4" "92.9" "94.8" "92.5" "88.3" "77.5" "106.2" "166.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "433622003842614050" "False" "High" "IsMasterProtein" "Q9NWA0" "Mediator of RNA polymerase II transcription subunit 9 OS=Homo sapiens OX=9606 GN=MED9 PE=1 SV=1" "0.000" "False" "19.495" "31" "3" "3" "3" "146" "16.4" "7.39" "12.94" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf07544" "55090" "ENSG00000141026" "MED9" "hsa:55090; Q9NWA0" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "Vitamin D receptor pathway; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "5" "0" "1.072" "1.126" "1.070" "1.092" "1.147" "1.065" "1.167" "1.257" "1.446" "184.5" "197.8" "207.8" "197.5" "201.6" "211.6" "196.6" "215.4" "231.9" "266.9" "" "" "" "" "" "" "" "" "" "" "163.6" "163.8" "181.4" "147.7" "168.1" "194.4" "166.1" "178.0" "212.7" "266.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974291959383986730" "False" "High" "IsMasterProtein" "Q9UL33" "Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1" "0.000" "False" "19.489" "36" "4" "4" "4" "140" "16.1" "6.77" "15.99" "4" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04628" "51693" "ENSG00000167515" "TRAPPC2L" "B2R4M9; hsa:51693; Q6ZTA7; Q9NZZ4; Q9UL33" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.002" "1.034" "0.970" "0.975" "1.056" "0.987" "0.996" "0.963" "1.885" "391.3" "392.0" "404.5" "379.5" "381.4" "413.2" "386.2" "389.8" "376.9" "737.6" "" "" "" "" "" "" "" "" "" "" "347.0" "324.7" "352.9" "283.8" "318.0" "379.6" "326.4" "322.2" "345.6" "737.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5153140893326454359" "False" "High" "IsMasterProtein" "Q99496" "E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1" "0.000" "False" "19.460" "13" "3" "3" "3" "336" "37.6" "6.84" "15.25" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "6045" "ENSG00000121481" "RNF2" "B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; Q99496" "Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "11" "0" "1.026" "1.008" "0.999" "1.012" "1.064" "1.056" "0.925" "1.040" "1.844" "407.8" "418.4" "411.1" "407.5" "412.8" "433.9" "430.6" "377.3" "424.1" "752.2" "" "" "" "" "" "" "" "" "" "" "361.7" "346.6" "358.7" "304.8" "344.2" "398.6" "363.9" "311.9" "389.0" "752.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "High" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.000" "False" "19.422" "23" "6" "9" "6" "231" "25.7" "6.02" "31.41" "6" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "0.869" "0.904" "0.817" "0.800" "0.865" "0.779" "0.857" "0.909" "0.813" "1500.5" "1304.5" "1356.0" "1225.3" "1201.0" "1298.2" "1168.3" "1285.9" "1363.6" "1219.5" "" "" "" "" "" "" "" "" "" "" "1330.6" "1080.6" "1183.2" "916.4" "1001.5" "1192.6" "987.4" "1062.9" "1250.6" "1219.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "High" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.000" "False" "19.413" "11" "4" "4" "4" "362" "41.8" "4.86" "15.71" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "1.067" "0.968" "0.910" "1.073" "1.083" "1.065" "0.946" "1.105" "1.417" "443.9" "473.7" "429.7" "403.8" "476.1" "480.9" "472.9" "419.8" "490.6" "628.9" "" "" "" "" "" "" "" "" "" "" "393.6" "392.4" "374.9" "302.0" "397.0" "441.8" "399.7" "347.0" "450.0" "628.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4771647564776910413" "False" "High" "IsMasterProtein" "Q96JC9" "ELL-associated factor 1 OS=Homo sapiens OX=9606 GN=EAF1 PE=1 SV=1" "0.000" "False" "19.397" "15" "4" "6" "4" "268" "29.0" "5.40" "20.48" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09816" "85403" "ENSG00000144597" "EAF1" "B4E3F5; hsa:85403; Q8IW10; Q96JC9" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "0.947" "0.952" "0.929" "0.948" "0.979" "0.957" "0.909" "0.951" "0.812" "918.2" "869.7" "873.7" "853.3" "870.4" "898.9" "879.0" "834.5" "873.6" "745.2" "" "" "" "" "" "" "" "" "" "" "814.2" "720.4" "762.4" "638.2" "725.8" "825.7" "742.9" "689.8" "801.2" "745.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-348929784632102448" "False" "High" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "0.000" "False" "19.392" "6" "2" "3" "2" "463" "52.5" "7.55" "13.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "1.058" "0.939" "1.215" "1.125" "1.039" "1.026" "1.035" "0.805" "0.523" "125.0" "132.3" "117.4" "151.9" "140.7" "129.9" "128.2" "129.4" "100.6" "65.4" "" "" "" "" "" "" "" "" "" "" "110.9" "109.6" "102.4" "113.6" "117.3" "119.3" "108.4" "106.9" "92.3" "65.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6611035198024909537" "False" "High" "IsMasterProtein" "O43167" "Zinc finger and BTB domain-containing protein 24 OS=Homo sapiens OX=9606 GN=ZBTB24 PE=1 SV=2" "0.000" "False" "19.387" "7" "4" "6" "4" "697" "78.2" "7.61" "19.31" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "9841" "ENSG00000112365" "ZBTB24" "hsa:9841; O43167; Q17RC6; Q5TED5; Q8N455" "" "" "0" "0" "1.092" "1.044" "1.064" "1.076" "1.090" "1.120" "1.012" "1.107" "0.960" "103.2" "112.7" "107.7" "109.8" "111.0" "112.5" "115.5" "104.5" "114.3" "99.1" "" "" "" "" "" "" "" "" "" "" "91.5" "93.4" "94.0" "82.1" "92.6" "103.3" "97.7" "86.3" "104.8" "99.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8273145356875318632" "False" "High" "IsMasterProtein" "Q9BXI6" "TBC1 domain family member 10A OS=Homo sapiens OX=9606 GN=TBC1D10A PE=1 SV=1" "0.000" "False" "19.354" "8" "4" "5" "4" "508" "57.1" "8.44" "16.51" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "83874" "ENSG00000099992" "TBC1D10A" "B3KXT8; hsa:83874; O76053; Q20WK7; Q543A2; Q9BXI6" "TBC/RABGAPs" "Deregulation of Rab and Rab effector genes in bladder cancer" "2" "0" "1.054" "0.943" "1.030" "0.991" "0.982" "0.974" "0.976" "1.073" "2.189" "311.0" "327.8" "293.4" "320.2" "308.1" "305.4" "303.0" "303.5" "333.7" "680.7" "" "" "" "" "" "" "" "" "" "" "275.8" "271.5" "256.0" "239.5" "256.9" "280.5" "256.1" "250.8" "306.0" "680.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993572615210098163" "False" "High" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "0.000" "False" "19.347" "4" "2" "3" "2" "622" "69.8" "6.84" "11.27" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "5q35 copy number variation" "5" "0" "0.979" "1.041" "1.026" "0.968" "0.930" "0.977" "0.884" "0.932" "1.320" "266.0" "260.3" "276.7" "272.8" "257.5" "247.4" "259.9" "235.1" "247.9" "351.1" "" "" "" "" "" "" "" "" "" "" "235.8" "215.6" "241.5" "204.0" "214.7" "227.3" "219.7" "194.3" "227.4" "351.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "19.347" "12" "4" "5" "3" "375" "42.2" "7.64" "17.99" "4" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "Peroxisomal lipid metabolism; Peroxisomal protein import" "" "2" "0" "1.113" "1.048" "1.207" "1.083" "1.047" "1.167" "1.172" "1.055" "0.662" "181.3" "201.9" "189.9" "218.9" "196.3" "189.8" "211.6" "212.5" "191.3" "120.0" "" "" "" "" "" "" "" "" "" "" "160.8" "167.2" "165.7" "163.7" "163.7" "174.4" "178.8" "175.6" "175.5" "120.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "19.307" "31" "4" "14" "1" "95" "10.9" "5.50" "48.63" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "SUMOylation of chromatin organization proteins; SUMOylation of intracellular receptors; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "TAR syndrome" "15" "0" "0.873" "0.970" "0.894" "0.800" "0.893" "0.666" "0.828" "0.722" "0.666" "350.3" "305.9" "339.9" "313.2" "280.4" "312.9" "233.2" "289.9" "253.1" "233.2" "" "" "" "" "" "" "" "" "" "" "310.6" "253.4" "296.6" "234.2" "233.8" "287.4" "197.1" "239.6" "232.1" "233.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824590419555307181" "False" "High" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.000" "False" "19.307" "36" "4" "10" "4" "101" "11.6" "5.52" "30.23" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Formation of Incision Complex in GG-NER; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "27" "0" "0.978" "0.818" "0.819" "0.696" "0.671" "0.572" "0.694" "0.757" "0.897" "1988.5" "1944.3" "1626.2" "1627.8" "1384.2" "1333.4" "1138.2" "1379.1" "1506.0" "1782.7" "" "" "" "" "" "" "" "" "" "" "1763.4" "1610.5" "1418.9" "1217.4" "1154.2" "1224.8" "962.0" "1140.0" "1381.2" "1782.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8371930933438372012" "False" "High" "IsMasterProtein" "P30039" "Phenazine biosynthesis-like domain-containing protein OS=Homo sapiens OX=9606 GN=PBLD PE=1 SV=2" "0.000" "False" "19.292" "20" "5" "6" "5" "288" "31.8" "6.52" "22.64" "5" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf02567" "64081" "ENSG00000108187" "PBLD" "A8MZJ3; C9JIM0; hsa:64081; P30039; Q9HCC2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036196760614096612" "False" "High" "IsMasterProtein" "P11802" "Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2" "0.000" "False" "19.287" "17" "5" "5" "4" "303" "33.7" "7.01" "17.53" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "1019" "ENSG00000135446" "CDK4" "B2R9A0; B4DNF9; hsa:1019; O00576; P11802; Q6FG61" "Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Transcriptional regulation of white adipocyte differentiation; Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; Transcriptional regulation by RUNX2; Meiotic recombination; Transcriptional regulation of granulopoiesis; PTK6 Regulates Cell Cycle; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Bladder cancer; PPAR-alpha pathway; Nuclear receptors meta-pathway; Ovarian infertility; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Sphingolipid metabolism in senescence; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; JAK-STAT signaling in the regulation of beta cells; DNA damage response" "47" "0" "1.111" "1.015" "1.118" "1.232" "1.076" "1.123" "1.151" "0.900" "0.995" "49.6" "55.1" "50.3" "55.4" "61.1" "53.3" "55.7" "57.1" "44.6" "49.3" "" "" "" "" "" "" "" "" "" "" "43.9" "45.6" "43.9" "41.4" "50.9" "49.0" "47.0" "47.2" "40.9" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "19.279" "4" "7" "7" "7" "2157" "243.2" "8.75" "20.25" "7" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "Vitamin D receptor pathway" "10" "0" "1.068" "0.897" "0.989" "0.857" "0.843" "0.972" "0.614" "0.908" "6.106" "115.4" "123.3" "103.5" "114.2" "98.9" "97.3" "112.2" "70.8" "104.8" "704.7" "" "" "" "" "" "" "" "" "" "" "102.4" "102.1" "90.3" "85.4" "82.5" "89.4" "94.8" "58.5" "96.1" "704.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3652671627369165893" "False" "High" "IsMasterProtein" "Q9HBM1" "Kinetochore protein Spc25 OS=Homo sapiens OX=9606 GN=SPC25 PE=1 SV=1" "0.000" "False" "19.270" "15" "2" "3" "2" "224" "26.1" "8.00" "14.96" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08234" "57405" "ENSG00000152253; ENSG00000277909" "SPC25" "A8K4X8; D3DPC0; hsa:57405; Q9HBM1" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.078" "0.967" "1.176" "1.075" "1.121" "1.097" "0.850" "1.129" "3.938" "267.8" "288.6" "259.0" "314.9" "287.8" "300.3" "293.8" "227.5" "302.2" "1054.5" "" "" "" "" "" "" "" "" "" "" "237.5" "239.1" "226.0" "235.5" "240.0" "275.9" "248.3" "188.1" "277.2" "1054.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1812209145391096347" "False" "High" "IsMasterProtein" "P07919" "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2" "0.000" "False" "19.253" "44" "4" "11" "4" "91" "10.7" "4.44" "40.88" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02320" "7388" "ENSG00000173660" "UQCRH" "B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "0.996" "1.051" "0.943" "1.005" "1.168" "1.041" "1.107" "1.155" "0.220" "1007.8" "1003.5" "1059.5" "950.6" "1012.7" "1177.3" "1048.8" "1116.1" "1163.6" "222.1" "" "" "" "" "" "" "" "" "" "" "893.7" "831.2" "924.5" "710.9" "844.5" "1081.5" "886.4" "922.5" "1067.2" "222.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1301679656055029716" "False" "High" "IsMasterProtein" "Q9BWG6" "Sodium channel modifier 1 OS=Homo sapiens OX=9606 GN=SCNM1 PE=1 SV=1" "0.000" "False" "19.241" "17" "3" "6" "3" "230" "25.9" "8.87" "13.16" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15803, Pf15805" "100534012; 79005" "ENSG00000163156" "SCNM1" "B4DWR1; hsa:100534012; hsa:79005; Q5JR74; Q9BWG6" "" "" "0" "0" "0.993" "0.911" "1.031" "0.972" "0.935" "1.076" "1.008" "0.868" "0.619" "179.0" "177.8" "163.0" "184.5" "174.0" "167.3" "192.6" "180.3" "155.4" "110.9" "" "" "" "" "" "" "" "" "" "" "158.7" "147.3" "142.2" "138.0" "145.1" "153.7" "162.8" "149.1" "142.5" "110.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7931435872977733703" "False" "High" "IsMasterProtein" "P05556" "Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 PE=1 SV=2" "0.000" "False" "19.240" "6" "5" "5" "5" "798" "88.4" "5.39" "18.11" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00362, Pf07965, Pf07974, Pf08725, Pf17205, Pf18372" "3688" "ENSG00000150093" "ITGB1" "A8K6N2; D3DRX9; D3DRY3; D3DRY4; D3DRY5; hsa:3688; P05556; P78466; P78467; Q13089; Q13090; Q13091; Q13212; Q14622; Q14647; Q29RW2; Q7Z3V1; Q8WUM6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Potential therapeutics for SARS; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases Activate Formins; HCMV Early Events; RAC2 GTPase cycle; RAC3 GTPase cycle; Integrin cell surface interactions; ECM proteoglycans; GPER1 signaling; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; Signal transduction by L1; Syndecan interactions; Other semaphorin interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions; Formation of the ureteric bud; Platelet Adhesion to exposed collagen; Molecules associated with elastic fibres; TGF-beta receptor signaling activates SMADs; Fibronectin matrix formation; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; MET interacts with TNS proteins" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Cells and molecules involved in local acute inflammatory response ; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Small cell lung cancer; Gastrin signaling pathway; Genes controlling nephrogenesis; Development of ureteric collection system; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; 11p11.2 copy number variation syndrome ; Macrophage-stimulating protein (MSP) signaling network map; TAR syndrome; Cell lineage map for neuronal differentiation" "58" "0" "1.098" "1.054" "1.102" "1.120" "1.153" "1.044" "1.106" "1.265" "0.775" "566.2" "621.5" "596.5" "624.1" "634.1" "652.6" "591.2" "625.9" "716.3" "438.8" "" "" "" "" "" "" "" "" "" "" "502.1" "514.8" "520.5" "466.7" "528.8" "599.5" "499.6" "517.4" "656.9" "438.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2299067407351932215" "False" "High" "IsMasterProtein" "P28907" "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 OS=Homo sapiens OX=9606 GN=CD38 PE=1 SV=2" "0.000" "False" "19.229" "20" "6" "6" "6" "300" "34.3" "7.66" "21.43" "6" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02267" "952" "ENSG00000004468" "CD38" "hsa:952; O00121; O00122; P28907; Q96HY4" "Nicotinate metabolism" "NAD+ metabolism; NAD+ biosynthetic pathways; Cell-type dependent selectivity of CCK2R signaling; Airway smooth muscle cell contraction" "5" "0" "1.146" "0.964" "1.039" "0.956" "0.938" "1.052" "0.973" "1.099" "1.301" "312.6" "358.3" "301.3" "324.8" "298.9" "293.2" "328.9" "304.3" "343.4" "406.6" "" "" "" "" "" "" "" "" "" "" "277.2" "296.8" "262.9" "242.9" "249.2" "269.4" "278.0" "251.5" "314.9" "406.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9020069583805455300" "False" "High" "IsMasterProtein" "O60234" "Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1" "0.000" "False" "19.212" "13" "2" "6" "1" "142" "16.8" "5.26" "23.05" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "9535" "ENSG00000130755; ENSG00000291873" "GMFG" "hsa:9535; O60234; Q6IB37" "Neutrophil degranulation" "" "1" "0" "1.026" "0.983" "1.043" "1.008" "0.982" "1.012" "0.979" "0.958" "0.719" "562.6" "577.0" "553.3" "587.0" "567.1" "552.3" "569.4" "550.5" "539.0" "404.4" "" "" "" "" "" "" "" "" "" "" "498.9" "478.0" "482.8" "439.0" "472.9" "507.4" "481.3" "455.0" "494.3" "404.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376018715288755929" "False" "High" "IsMasterProtein" "O95249" "Golgi SNAP receptor complex member 1 OS=Homo sapiens OX=9606 GN=GOSR1 PE=1 SV=1" "0.000" "False" "19.209" "21" "6" "8" "6" "250" "28.6" "9.42" "23.24" "6" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf12352" "9527" "ENSG00000108587" "GOSR1" "hsa:9527; J3KST5; O75392; O95249" "Intra-Golgi traffic; COPI-mediated anterograde transport" "" "2" "0" "1.019" "0.991" "0.978" "0.988" "0.974" "1.008" "0.971" "1.036" "0.705" "765.7" "780.0" "758.6" "748.6" "756.3" "745.8" "771.5" "743.1" "793.1" "540.1" "" "" "" "" "" "" "" "" "" "" "679.0" "646.1" "661.9" "559.9" "630.7" "685.1" "652.0" "614.2" "727.3" "540.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340635961720124479" "False" "High" "IsMasterProtein" "O75140" "GATOR1 complex protein DEPDC5 OS=Homo sapiens OX=9606 GN=DEPDC5 PE=1 SV=2" "0.000" "False" "19.185" "3" "4" "4" "4" "1603" "181.1" "6.73" "14.41" "4" "stress response;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00610, Pf12257, Pf19418" "9681" "ENSG00000100150" "DEPDC5" "A6H8V6; A8MPX9; B4DH93; B9EGN9; hsa:9681; O75140; Q5K3V5; Q5THY9; Q5THZ0; Q5THZ1; Q5THZ3; Q68DR1; Q6MZX3; Q6PEZ1; Q9UGV8; Q9UH13" "Amino acids regulate mTORC1" "22q11.2 copy number variation syndrome" "2" "0" "0.958" "0.921" "0.920" "1.010" "0.979" "0.917" "0.970" "0.913" "1.451" "176.0" "168.7" "162.1" "162.0" "177.7" "172.3" "161.3" "170.8" "160.7" "255.5" "" "" "" "" "" "" "" "" "" "" "156.1" "139.8" "141.4" "121.1" "148.2" "158.3" "136.4" "141.2" "147.4" "255.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "19.181" "24" "5" "12" "5" "167" "19.4" "7.40" "33.53" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "0.974" "0.984" "1.028" "0.972" "1.064" "0.973" "1.026" "0.932" "0.506" "951.7" "927.0" "936.6" "978.2" "924.8" "1012.4" "926.1" "976.7" "886.9" "481.1" "" "" "" "" "" "" "" "" "" "" "844.0" "767.9" "817.2" "731.6" "771.1" "930.0" "782.7" "807.3" "813.4" "481.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6299048692266605018" "False" "High" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "0.000" "False" "19.176" "9" "7" "8" "6" "759" "84.5" "7.23" "18.88" "7" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "Integrin-mediated cell adhesion" "9" "1" "0.991" "0.947" "0.949" "0.942" "0.976" "0.972" "0.839" "0.923" "2.706" "554.1" "549.4" "524.7" "526.0" "521.8" "540.9" "538.8" "465.1" "511.4" "1499.5" "" "" "" "" "" "" "" "" "" "" "491.4" "455.1" "457.9" "393.4" "435.1" "496.9" "455.4" "384.4" "469.0" "1499.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1645614495321622240" "False" "High" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "0.000" "False" "19.159" "5" "5" "5" "5" "1058" "120.0" "6.04" "16.58" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "1.118" "0.875" "1.272" "0.989" "0.993" "1.108" "0.405" "0.995" "13.180" "175.5" "196.2" "153.5" "223.3" "173.6" "174.2" "194.4" "71.0" "174.6" "2313.0" "" "" "" "" "" "" "" "" "" "" "155.6" "162.5" "133.9" "167.0" "144.8" "160.0" "164.3" "58.7" "160.1" "2313.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "19.152" "20" "3" "5" "3" "156" "17.9" "5.08" "21.10" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "0.869" "0.834" "1.139" "1.056" "0.930" "1.597" "1.424" "1.481" "3.162" "457.2" "397.2" "381.3" "520.9" "482.8" "425.2" "730.1" "650.8" "677.0" "1445.7" "" "" "" "" "" "" "" "" "" "" "405.4" "329.0" "332.7" "389.6" "402.6" "390.6" "617.1" "537.9" "620.9" "1445.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "19.148" "21" "2" "4" "2" "104" "11.4" "9.25" "15.22" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "0.954" "0.968" "0.970" "0.961" "1.035" "0.767" "0.880" "0.907" "1.389" "118.0" "112.6" "114.2" "114.5" "113.4" "122.1" "90.5" "103.9" "107.1" "163.9" "" "" "" "" "" "" "" "" "" "" "104.7" "93.3" "99.7" "85.6" "94.5" "112.2" "76.5" "85.9" "98.2" "163.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3838187860165332500" "False" "High" "IsMasterProtein" "P52564" "Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1" "0.000" "False" "19.133" "15" "5" "5" "5" "334" "37.5" "7.39" "17.64" "5" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5608" "ENSG00000108984" "MAP2K6" "hsa:5608; P52564" "PKR-mediated signaling; Interleukin-1 signaling; Oxidative Stress Induced Senescence; Myogenesis; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; PI5P Regulates TP53 Acetylation" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "41" "0" "0.997" "0.933" "1.046" "1.032" "1.009" "1.172" "0.949" "1.098" "2.922" "356.5" "355.5" "332.8" "373.0" "367.9" "359.8" "417.9" "338.3" "391.3" "1041.9" "" "" "" "" "" "" "" "" "" "" "316.2" "294.5" "290.4" "279.0" "306.7" "330.5" "353.2" "279.6" "358.9" "1041.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "342990274906048664" "False" "High" "IsMasterProtein" "P48730" "Casein kinase I isoform delta OS=Homo sapiens OX=9606 GN=CSNK1D PE=1 SV=2" "0.000" "False" "19.123" "8" "3" "3" "3" "415" "47.3" "9.74" "12.25" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1453" "ENSG00000141551" "CSNK1D" "A2I2P2; hsa:1453; P48730; Q96KZ6; Q9BTN5" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock; Major pathway of rRNA processing in the nucleolus and cytosol; COPII-mediated vesicle transport" "Melatonin metabolism and effects; Wnt signaling pathway; Hedgehog signaling pathway" "13" "0" "0.994" "1.040" "0.999" "1.031" "1.033" "0.959" "0.961" "0.943" "1.142" "108.2" "107.5" "112.6" "108.1" "111.6" "111.8" "103.8" "104.0" "102.1" "123.6" "" "" "" "" "" "" "" "" "" "" "96.0" "89.1" "98.2" "80.9" "93.1" "102.7" "87.7" "86.0" "93.6" "123.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.000" "False" "19.118" "24" "5" "6" "5" "198" "23.0" "7.93" "21.15" "5" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "PI Metabolism" "" "1" "0" "0.973" "1.053" "1.056" "0.984" "0.983" "1.017" "1.075" "0.983" "1.109" "544.8" "530.0" "573.6" "575.1" "536.2" "535.5" "554.3" "585.6" "535.4" "604.1" "" "" "" "" "" "" "" "" "" "" "483.1" "439.1" "500.5" "430.1" "447.1" "491.9" "468.4" "484.1" "491.0" "604.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6830968360322984650" "False" "High" "IsMasterProtein" "Q9BTV6" "Diphthine methyltransferase OS=Homo sapiens OX=9606 GN=DPH7 PE=1 SV=2" "0.000" "False" "19.107" "13" "5" "5" "5" "452" "50.5" "6.60" "17.99" "5" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00400" "92715" "ENSG00000148399" "DPH7" "hsa:92715; Q96AB7; Q9BTV6" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.003" "0.909" "0.954" "0.907" "0.987" "0.990" "0.963" "0.960" "0.552" "618.7" "620.4" "562.4" "590.2" "560.9" "610.8" "612.3" "595.7" "594.0" "341.8" "" "" "" "" "" "" "" "" "" "" "548.6" "513.9" "490.7" "441.4" "467.7" "561.1" "517.5" "492.4" "544.8" "341.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.000" "False" "19.092" "21" "3" "6" "3" "160" "18.3" "4.88" "24.26" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "" "2q11.2 copy number variation syndrome" "1" "0" "1.021" "1.070" "1.061" "1.097" "1.069" "1.012" "1.074" "1.005" "0.571" "673.8" "687.8" "720.9" "714.8" "739.1" "720.0" "681.6" "723.8" "677.1" "384.4" "" "" "" "" "" "" "" "" "" "" "597.5" "569.8" "629.0" "534.6" "616.3" "661.4" "576.0" "598.3" "621.0" "384.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "High" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.000" "False" "19.076" "9" "6" "7" "5" "639" "70.3" "5.29" "22.80" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "TBC/RABGAPs; Amyloid fiber formation" "" "2" "0" "0.939" "0.923" "0.964" "0.942" "0.932" "1.003" "0.921" "0.950" "1.265" "1226.5" "1151.8" "1132.4" "1182.7" "1155.6" "1143.4" "1230.6" "1130.1" "1165.3" "1551.8" "" "" "" "" "" "" "" "" "" "" "1087.7" "954.1" "988.1" "884.5" "963.6" "1050.4" "1040.0" "934.1" "1068.7" "1551.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739336077855480502" "False" "High" "IsMasterProtein" "Q9NWY4" "Histone PARylation factor 1 OS=Homo sapiens OX=9606 GN=HPF1 PE=1 SV=2" "0.000" "False" "19.059" "10" "3" "3" "3" "346" "39.4" "6.80" "12.94" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10228" "54969" "ENSG00000056050" "HPF1" "hsa:54969; Q9NWY4" "" "" "0" "0" "1.089" "0.948" "1.227" "1.066" "1.003" "1.086" "0.258" "0.914" "16.920" "184.8" "201.2" "175.2" "226.8" "197.0" "185.3" "200.7" "47.6" "169.0" "3126.3" "" "" "" "" "" "" "" "" "" "" "163.9" "166.7" "152.8" "169.6" "164.3" "170.2" "169.6" "39.3" "155.0" "3126.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1970257073034718295" "False" "High" "IsMasterProtein" "Q6RW13" "Type-1 angiotensin II receptor-associated protein OS=Homo sapiens OX=9606 GN=AGTRAP PE=1 SV=1" "0.000" "False" "19.050" "30" "3" "3" "3" "159" "17.4" "6.14" "13.05" "3" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf06396" "57085" "ENSG00000177674" "AGTRAP" "A8MVQ5; hsa:57085; Q5SNV4; Q5SNV5; Q6RW13; Q96AC0; Q96PL4; Q9NRW9" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "1.155" "1.031" "1.031" "1.142" "1.129" "1.154" "1.109" "0.929" "0.895" "131.5" "151.9" "135.6" "135.5" "150.2" "148.5" "151.8" "145.9" "122.1" "117.7" "" "" "" "" "" "" "" "" "" "" "116.6" "125.8" "118.3" "101.4" "125.3" "136.4" "128.3" "120.6" "112.0" "117.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7033934706938727348" "False" "High" "IsMasterProtein" "Q9UNY4" "Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2" "0.000" "False" "19.047" "4" "4" "4" "4" "1162" "129.5" "8.37" "15.36" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf06839" "8458" "ENSG00000116830" "TTF2" "A8K4Q2; hsa:8458; O75921; Q5T2K7; Q5VVU8; Q8N6I8; Q9UNY4" "" "Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "2" "0" "1.056" "1.007" "1.078" "0.976" "1.122" "1.075" "0.636" "1.093" "8.084" "343.7" "362.8" "346.2" "370.6" "335.5" "385.7" "369.5" "218.7" "375.5" "2778.4" "" "" "" "" "" "" "" "" "" "" "304.8" "300.6" "302.1" "277.1" "279.8" "354.3" "312.3" "180.8" "344.4" "2778.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002470481848011023" "False" "High" "IsMasterProtein" "Q9P032" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1" "0.000" "False" "19.046" "24" "5" "6" "5" "175" "20.3" "8.82" "21.14" "5" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf06784" "29078" "ENSG00000123545" "NDUFAF4" "B2R4J5; hsa:29078; Q9P032" "Complex I biogenesis" "" "1" "0" "1.040" "1.016" "0.966" "1.079" "1.187" "0.951" "0.894" "1.019" "1.241" "806.9" "839.4" "819.8" "779.3" "870.5" "957.7" "767.7" "721.7" "822.5" "1001.6" "" "" "" "" "" "" "" "" "" "" "715.5" "695.3" "715.3" "582.8" "725.8" "879.8" "648.8" "596.5" "754.3" "1001.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4037115124737055274" "False" "High" "IsMasterProtein" "P04439" "HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2" "0.000" "False" "19.037" "7" "2" "3" "1" "365" "40.8" "6.00" "13.46" "2" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3105" "ENSG00000206503" "HLA-A" "B1PKZ3; hsa:3105; O02939; O02954; O02955; O02963; O19509; O19546; O19598; O19605; O19606; O19619; O19647; O19673; O19687; O19695; O19756; O19794; O19795; O43906; O43907; O46874; O62921; O62924; O77937; O77938; O77964; O78073; O78171; O98009; O98010; O98011; O98137; P01891; P01892; P04439; P05534; P06338; P10313; P10314; P10315; P10316; P13746; P16188; P16189; P16190; P18462; P30443; P30444; P30445; P30446; P30447; P30448; P30449; P30450; P30451; P30452; P30453; P30454; P30455; P30456; P30457; P30458; P30459; P30512; P30514; P79505; P79562; P79563; Q09160; Q29680; Q29747; Q29835; Q29837; Q29838; Q29899; Q29908; Q29909; Q29910; Q30208; Q31623; Q5S3G1; Q65A82; Q8MHM1; Q8MHN9; Q95352; Q95355; Q95362; Q95377; Q95380; Q95IZ5; Q9BCN0; Q9BD15; Q9BD19; Q9GJE6; Q9GJE7; Q9GJE8; Q9MW42; Q9MY89; Q9MYA3; Q9MYA5; Q9MYC4; Q9MYE6; Q9MYE9; Q9MYG4; Q9MYG5; Q9MYI5; Q9TP25; Q9TPQ3; Q9TPR8; Q9TPX8; Q9TPX9; Q9TPY0; Q9TQ24; Q9TQE8; Q9TQE9; Q9TQF1; Q9TQF5; Q9TQF8; Q9TQF9; Q9TQG0; Q9TQG5; Q9TQG7; Q9TQH5; Q9TQI3; Q9TQK5; Q9TQM6; Q9TQN5; Q9TQP5; Q9TQP6; Q9TQP7; Q9UIN1; Q9UIN2; Q9UIP7; Q9UQU3; Q9UQU6; Q9UQU7" "ER-Phagosome pathway; Nef mediated downregulation of MHC class I complex cell surface expression; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; E3 ubiquitin ligases ubiquitinate target proteins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; TAR syndrome" "14" "0" "1.331" "1.119" "1.272" "1.267" "1.240" "1.253" "1.142" "1.374" "0.736" "209.6" "278.9" "234.5" "266.5" "265.6" "259.9" "262.7" "239.4" "287.9" "154.2" "" "" "" "" "" "" "" "" "" "" "185.8" "231.1" "204.6" "199.3" "221.4" "238.8" "222.0" "197.9" "264.0" "154.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3252394429536465777" "False" "High" "IsMasterProtein" "Q32P41" "tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=3" "0.000" "False" "19.023" "10" "6" "7" "6" "509" "58.2" "8.62" "22.55" "6" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02475" "57570" "ENSG00000126814" "TRMT5" "B2RN19; hsa:57570; Q32P41; Q9P2F4" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "0.906" "0.784" "0.971" "0.800" "0.766" "0.788" "0.449" "0.804" "8.019" "301.5" "273.3" "236.3" "292.9" "241.3" "231.1" "237.6" "135.4" "242.4" "2418.0" "" "" "" "" "" "" "" "" "" "" "267.4" "226.4" "206.2" "219.0" "201.2" "212.3" "200.8" "112.0" "222.3" "2418.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8184691105517631334" "False" "High" "IsMasterProtein" "Q9P035" "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2" "0.000" "False" "19.006" "10" "4" "5" "4" "362" "43.1" "8.94" "16.34" "4" "other metabolic processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus" "enzyme regulator activity;other molecular function" "Pf04387" "51495" "ENSG00000074696" "HACD3" "A0PJA1; B4DRF4; hsa:51495; Q280Z3; Q6PD63; Q8IUI5; Q8NC86; Q8NCB1; Q96T12; Q9NQA7; Q9P035" "Synthesis of very long-chain fatty acyl-CoAs" "" "1" "0" "1.029" "1.012" "1.075" "1.172" "1.194" "1.183" "1.126" "1.053" "0.288" "483.2" "497.3" "489.1" "519.5" "566.1" "577.1" "571.4" "544.1" "508.9" "139.1" "" "" "" "" "" "" "" "" "" "" "428.5" "411.9" "426.7" "388.5" "472.0" "530.1" "482.9" "449.7" "466.7" "139.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5002411829564885472" "False" "High" "IsMasterProtein" "Q9GZQ8" "Microtubule-associated proteins 1A/1B light chain 3B OS=Homo sapiens OX=9606 GN=MAP1LC3B PE=1 SV=3" "0.000" "False" "18.998" "17" "2" "10" "2" "125" "14.7" "8.94" "29.21" "2" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "81631" "ENSG00000140941" "MAP1LC3B" "hsa:81631; Q6NW02; Q9GZQ8" "KEAP1-NFE2L2 pathway; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; PINK1-PRKN Mediated Mitophagy; TBC/RABGAPs; Receptor Mediated Mitophagy; Pexophagy; SARS-CoV-2 modulates autophagy" "Ferroptosis; Autophagy; Opioid receptor pathways; Network map of SARS-CoV-2 signaling pathway; Clock-controlled autophagy in bone metabolism; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "16" "0" "1.019" "1.013" "0.979" "1.018" "1.086" "1.100" "1.053" "0.908" "0.604" "685.1" "698.3" "693.8" "670.9" "697.7" "743.7" "753.4" "721.5" "622.0" "413.5" "" "" "" "" "" "" "" "" "" "" "607.6" "578.5" "605.4" "501.8" "581.8" "683.2" "636.8" "596.4" "570.4" "413.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6226740505465900925" "False" "High" "IsMasterProtein" "Q08170" "Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2" "0.000" "False" "18.965" "8" "4" "6" "1" "494" "56.6" "11.52" "19.16" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6429" "ENSG00000116350" "SRSF4" "hsa:6429; Q08170; Q5VXP1; Q9BUA4; Q9UEB5" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "1.139" "1.363" "1.357" "1.038" "1.252" "1.024" "1.213" "1.218" "1.083" "13.5" "15.4" "18.5" "18.4" "14.1" "17.0" "13.9" "16.4" "16.5" "14.7" "" "" "" "" "" "" "" "" "" "" "12.0" "12.8" "16.1" "13.7" "11.7" "15.6" "11.7" "13.6" "15.1" "14.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001709167677346758" "False" "High" "IsMasterProtein" "Q9Y305" "Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2" "0.000" "False" "18.948" "8" "4" "6" "4" "439" "49.9" "8.60" "16.99" "4" "other metabolic processes" "mitochondrion" "other molecular function" "" "23597" "ENSG00000123130" "ACOT9" "B3KNC9; B7ZM94; hsa:23597; Q9Y305" "Mitochondrial Fatty Acid Beta-Oxidation" "VEGFA-VEGFR2 signaling" "2" "0" "0.929" "0.912" "1.093" "1.010" "0.948" "1.053" "1.114" "1.141" "0.970" "387.5" "360.1" "353.5" "423.7" "391.3" "367.4" "407.9" "431.5" "442.3" "376.1" "" "" "" "" "" "" "" "" "" "" "343.7" "298.3" "308.4" "316.9" "326.3" "337.5" "344.8" "356.7" "405.6" "376.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.000" "False" "18.944" "8" "4" "6" "3" "480" "52.6" "6.37" "21.14" "4" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "1.032" "0.993" "1.187" "1.147" "1.038" "0.986" "1.089" "1.058" "0.992" "327.9" "338.2" "325.6" "389.3" "376.0" "340.3" "323.4" "357.0" "346.9" "325.2" "" "" "" "" "" "" "" "" "" "" "290.8" "280.2" "284.1" "291.1" "313.5" "312.6" "273.3" "295.1" "318.1" "325.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3632960594176974073" "False" "High" "IsMasterProtein" "Q9UPN9" "E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3" "0.000" "False" "18.931" "4" "4" "4" "4" "1127" "122.5" "6.67" "14.67" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf00643" "51592" "ENSG00000197323" "TRIM33" "hsa:51592; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; Q9UPN9" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation" "Ectoderm differentiation" "3" "0" "1.261" "0.925" "1.203" "1.002" "0.954" "0.974" "0.491" "0.950" "8.251" "144.9" "182.7" "133.9" "174.2" "145.1" "138.2" "141.1" "71.1" "137.6" "1195.3" "" "" "" "" "" "" "" "" "" "" "128.5" "151.3" "116.9" "130.3" "121.0" "126.9" "119.3" "58.8" "126.2" "1195.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9115702628811982031" "False" "High" "IsMasterProtein" "Q8N5A5" "Zinc finger CCCH-type with G patch domain-containing protein OS=Homo sapiens OX=9606 GN=ZGPAT PE=1 SV=3" "0.000" "False" "18.920" "13" "5" "5" "5" "531" "57.3" "5.43" "16.19" "5" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf18044" "84619" "ENSG00000197114" "ZGPAT" "E1P5K1; hsa:84619; Q4VXN9; Q5JWI9; Q5JWJ0; Q8N5A5; Q8NC55; Q8WUV4; Q96JI0; Q96JU4; Q9H401" "" "" "0" "0" "1.066" "0.866" "1.080" "1.010" "0.834" "0.960" "0.690" "0.892" "2.274" "249.4" "265.8" "215.9" "269.3" "251.8" "208.0" "239.4" "172.0" "222.4" "567.1" "" "" "" "" "" "" "" "" "" "" "221.1" "220.2" "188.4" "201.4" "210.0" "191.1" "202.4" "142.2" "203.9" "567.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004394019571150397" "False" "High" "IsMasterProtein" "P25942" "Tumor necrosis factor receptor superfamily member 5 OS=Homo sapiens OX=9606 GN=CD40 PE=1 SV=1" "0.000" "False" "18.904" "16" "3" "3" "3" "277" "30.6" "5.76" "14.38" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00020" "958" "ENSG00000101017" "CD40" "E1P5S9; hsa:958; P25942; Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0" "" "Allograft rejection; Complement system; Vitamin D receptor pathway; Nod-like receptor (NLR) signaling pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Platelet-mediated interactions with vascular and circulating cells; Inflammatory response pathway; Genes associated with the development of rheumatoid arthritis; Extrafollicular and follicular B cell activation by SARS-CoV-2; Toll-like receptor signaling pathway" "10" "0" "1.095" "0.969" "1.075" "0.928" "1.043" "1.042" "1.024" "1.083" "0.600" "131.5" "144.0" "127.4" "141.4" "122.0" "137.1" "137.1" "134.7" "142.4" "78.9" "" "" "" "" "" "" "" "" "" "" "116.6" "119.3" "111.2" "105.8" "101.7" "126.0" "115.8" "111.3" "130.6" "78.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5299456138050834551" "False" "High" "IsMasterProtein" "O00115" "Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2" "0.000" "False" "18.899" "11" "4" "7" "4" "360" "39.6" "8.05" "20.25" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf03265" "1777" "ENSG00000105612" "DNASE2" "B2RD06; B7Z4K6; hsa:1777; O00115; O43910" "Lysosome Vesicle Biogenesis" "" "1" "0" "1.048" "1.018" "1.028" "1.042" "1.023" "0.979" "1.038" "1.063" "0.530" "586.4" "614.8" "597.0" "603.1" "611.1" "599.9" "574.0" "608.4" "623.2" "310.5" "" "" "" "" "" "" "" "" "" "" "520.0" "509.3" "521.0" "451.1" "509.6" "551.0" "485.1" "502.9" "571.5" "310.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.000" "False" "18.869" "15" "4" "5" "4" "320" "35.3" "8.22" "18.89" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "5" "0" "0.948" "0.941" "0.923" "0.972" "1.139" "1.074" "0.526" "1.024" "8.382" "213.0" "202.0" "200.5" "196.5" "207.0" "242.5" "228.9" "112.0" "218.1" "1785.5" "" "" "" "" "" "" "" "" "" "" "188.9" "167.4" "175.0" "147.0" "172.6" "222.8" "193.4" "92.6" "200.0" "1785.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5478644363893045592" "False" "High" "IsMasterProtein" "P60002" "Transcription elongation factor 1 homolog OS=Homo sapiens OX=9606 GN=ELOF1 PE=1 SV=1" "0.000" "False" "18.866" "22" "1" "4" "1" "83" "9.5" "8.00" "25.13" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf05129" "84337" "ENSG00000130165" "ELOF1" "hsa:84337; P60002; Q8R1J7; Q96II4" "" "" "0" "0" "0.941" "0.988" "0.959" "0.931" "0.974" "0.953" "1.049" "1.006" "0.523" "659.2" "620.0" "651.1" "632.2" "613.8" "642.3" "628.4" "691.7" "663.1" "344.9" "" "" "" "" "" "" "" "" "" "" "584.5" "513.6" "568.1" "472.8" "511.8" "590.0" "531.1" "571.8" "608.2" "344.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4999747194437679436" "False" "High" "IsMasterProtein" "Q969M7" "NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1" "0.000" "False" "18.818" "28" "5" "5" "5" "185" "21.1" "6.79" "17.26" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "140739" "ENSG00000184182" "UBE2F" "A8K1Z8; B4DDT9; B4DFI1; B4DMK3; B4DZU2; B8ZZG2; C9J212; H9KVB9; Q969M7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2q37 copy number variation syndrome" "3" "0" "0.963" "0.867" "0.879" "0.805" "0.795" "0.733" "0.879" "0.853" "0.494" "638.0" "614.3" "553.2" "560.9" "513.4" "507.4" "467.5" "560.5" "544.4" "314.9" "" "" "" "" "" "" "" "" "" "" "565.8" "508.9" "482.7" "419.5" "428.1" "466.1" "395.1" "463.3" "499.3" "314.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8350052096889729945" "False" "High" "IsMasterProtein" "O95670" "V-type proton ATPase subunit G 2 OS=Homo sapiens OX=9606 GN=ATP6V1G2 PE=1 SV=1" "0.000" "False" "18.806" "19" "2" "4" "2" "118" "13.6" "10.26" "14.59" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "534" "ENSG00000206445; ENSG00000213760; ENSG00000226850; ENSG00000227587; ENSG00000230900; ENSG00000234668; ENSG00000234920" "ATP6V1G2" "B5MEF0; hsa:534; O95670; Q2L6F8; Q5HYU8; Q5RJ63" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "" "5" "0" "1.047" "1.124" "1.200" "1.174" "1.307" "1.099" "1.212" "1.231" "0.642" "120.7" "126.4" "135.6" "144.7" "141.6" "157.7" "132.6" "146.3" "148.6" "77.4" "" "" "" "" "" "" "" "" "" "" "107.0" "104.7" "118.3" "108.2" "118.1" "144.9" "112.0" "120.9" "136.3" "77.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4597879666501405539" "False" "High" "IsMasterProtein" "Q9NX08" "COMM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=COMMD8 PE=1 SV=1" "0.000" "False" "18.802" "16" "2" "4" "2" "183" "21.1" "5.43" "18.07" "2" "" "cytosol;nucleus" "" "Pf07258" "54951" "ENSG00000169019" "COMMD8" "hsa:54951; Q8WUR4; Q9HC15; Q9NX08" "Neddylation" "" "1" "0" "1.129" "1.124" "1.120" "1.135" "1.137" "1.158" "1.025" "1.190" "1.482" "355.4" "401.1" "399.4" "398.1" "403.2" "403.9" "411.5" "364.2" "422.9" "526.5" "" "" "" "" "" "" "" "" "" "" "315.1" "332.3" "348.5" "297.7" "336.2" "371.0" "347.8" "301.1" "387.9" "526.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826640121646055106" "False" "High" "IsMasterProtein" "P13473" "Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2" "0.000" "False" "18.800" "9" "4" "5" "4" "410" "44.9" "5.63" "16.44" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3920" "ENSG00000005893" "LAMP2" "A8K4X5; D3DTF0; hsa:3920; P13473; Q16641; Q6Q3G8; Q96J30; Q99534; Q9UD93" "Neutrophil degranulation; Platelet degranulation ; Chaperone Mediated Autophagy" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Clock-controlled autophagy in bone metabolism" "5" "0" "1.082" "1.122" "1.238" "1.146" "1.079" "1.004" "1.100" "1.195" "0.555" "207.5" "224.4" "232.8" "256.9" "237.7" "223.9" "208.4" "228.2" "248.0" "115.1" "" "" "" "" "" "" "" "" "" "" "184.0" "185.9" "203.1" "192.1" "198.2" "205.7" "176.1" "188.6" "227.4" "115.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.000" "False" "18.792" "30" "4" "5" "4" "184" "20.3" "8.22" "19.99" "4" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "Complex I biogenesis" "" "1" "0" "1.194" "1.140" "1.204" "1.115" "1.114" "1.099" "1.024" "0.958" "0.692" "397.8" "475.1" "453.4" "479.2" "443.5" "443.1" "437.3" "407.3" "381.3" "275.5" "" "" "" "" "" "" "" "" "" "" "352.8" "393.6" "395.6" "358.4" "369.8" "407.0" "369.6" "336.6" "349.7" "275.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4671672968224421805" "False" "High" "IsMasterProtein" "Q9NVK5" "FGFR1 oncogene partner 2 OS=Homo sapiens OX=9606 GN=FGFR1OP2 PE=1 SV=1" "0.000" "False" "18.736" "19" "4" "4" "4" "253" "29.4" "6.00" "15.23" "4" "stress response" "cytosol" "other molecular function" "Pf05769" "26127" "ENSG00000111790" "FGFR1OP2" "hsa:26127; Q6R955; Q8N5L7; Q9NVK5; Q9P034; Q9UFK8" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "1.156" "0.983" "1.107" "1.146" "1.031" "1.132" "1.044" "1.044" "0.749" "127.1" "146.9" "124.9" "140.7" "145.6" "131.0" "143.9" "132.7" "132.7" "95.2" "" "" "" "" "" "" "" "" "" "" "112.7" "121.7" "109.0" "105.2" "121.4" "120.3" "121.6" "109.7" "121.7" "95.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6070529034068729651" "False" "High" "IsMasterProtein" "Q8TEV9" "Guanine nucleotide exchange protein SMCR8 OS=Homo sapiens OX=9606 GN=SMCR8 PE=1 SV=2" "0.000" "False" "18.694" "5" "4" "4" "4" "937" "105.0" "5.58" "13.85" "4" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11704" "140775" "ENSG00000176994; ENSG00000283741" "SMCR8" "A5PKZ5; hsa:140775; Q3ZCN0; Q6PJL3; Q8TEV9" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "1.028" "1.050" "1.100" "1.028" "1.073" "1.039" "0.892" "0.910" "1.885" "331.2" "340.6" "347.9" "364.3" "340.4" "355.5" "344.2" "295.6" "301.5" "624.2" "" "" "" "" "" "" "" "" "" "" "293.7" "282.1" "303.6" "272.5" "283.9" "326.6" "290.9" "244.3" "276.6" "624.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "High" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.000" "False" "18.671" "19" "3" "5" "3" "197" "21.6" "5.45" "18.70" "3" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.955" "0.930" "0.957" "1.030" "1.103" "0.889" "1.056" "1.039" "0.565" "185.5" "177.2" "172.6" "177.5" "191.1" "204.5" "164.9" "195.8" "192.8" "104.8" "" "" "" "" "" "" "" "" "" "" "164.5" "146.8" "150.6" "132.8" "159.4" "187.9" "139.4" "161.8" "176.8" "104.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463024331811541084" "False" "High" "IsMasterProtein" "Q15054" "DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2" "0.000" "False" "18.654" "8" "4" "5" "4" "466" "51.4" "9.35" "17.71" "4" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf09507" "10714" "ENSG00000077514" "POLD3" "B7ZAI6; hsa:10714; Q15054; Q32MZ9; Q32N00" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "26" "0" "1.008" "0.999" "0.866" "0.902" "1.004" "0.988" "0.823" "0.996" "4.145" "375.6" "378.5" "375.2" "325.3" "338.7" "376.9" "370.9" "308.9" "374.2" "1556.5" "" "" "" "" "" "" "" "" "" "" "333.0" "313.5" "327.4" "243.3" "282.4" "346.2" "313.5" "255.4" "343.2" "1556.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "High" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.000" "False" "18.641" "18" "6" "6" "6" "390" "44.3" "8.53" "18.53" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "Cell surface interactions at the vascular wall; Transcriptional regulation of white adipocyte differentiation; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "95" "0" "1.225" "1.170" "1.104" "1.096" "1.246" "1.218" "1.271" "1.085" "0.596" "286.3" "350.6" "335.0" "316.2" "313.8" "356.8" "348.8" "364.0" "310.7" "170.6" "" "" "" "" "" "" "" "" "" "" "253.9" "290.4" "292.3" "236.5" "261.7" "327.8" "294.8" "300.9" "285.0" "170.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7569413463716614588" "False" "High" "IsMasterProtein" "Q8N6M0" "Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1" "0.000" "False" "18.631" "16" "5" "6" "5" "293" "33.8" "6.05" "18.96" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf02338" "51633" "ENSG00000155100" "OTUD6B" "A8K6I1; B4DEY0; hsa:51633; Q8N6M0; Q9NTA4; Q9Y387" "" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "1" "0" "1.064" "0.954" "1.002" "1.017" "0.905" "1.093" "0.764" "0.961" "4.369" "369.3" "392.8" "352.3" "370.0" "375.6" "334.1" "403.7" "282.0" "355.0" "1613.4" "" "" "" "" "" "" "" "" "" "" "327.5" "325.4" "307.4" "276.7" "313.2" "306.9" "341.2" "233.1" "325.6" "1613.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1681183959761710458" "False" "High" "IsMasterProtein" "Q96G28" "Cilia- and flagella-associated protein 36 OS=Homo sapiens OX=9606 GN=CFAP36 PE=1 SV=2" "0.000" "False" "18.577" "14" "3" "3" "3" "342" "39.4" "4.97" "11.60" "3" "" "cytoskeleton;nucleus;other cell component" "" "Pf11527" "112942" "ENSG00000163001" "CFAP36" "hsa:112942; Q53SF0; Q53ST9; Q6UY34; Q96G28" "" "" "0" "0" "1.049" "0.913" "1.046" "1.168" "1.123" "1.119" "0.992" "1.265" "1.125" "83.6" "87.7" "76.3" "87.5" "97.7" "93.9" "93.6" "82.9" "105.8" "94.1" "" "" "" "" "" "" "" "" "" "" "74.1" "72.6" "66.6" "65.4" "81.4" "86.3" "79.1" "68.5" "97.0" "94.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120565565592818035" "False" "High" "IsMasterProtein" "P23443" "Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2" "0.000" "False" "18.550" "11" "6" "6" "6" "525" "59.1" "6.65" "21.25" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6198" "ENSG00000108443" "RPS6KB1" "B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; hsa:6198; P23443; Q7Z721" "mTORC1-mediated signalling" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL6 signaling pathway; BDNF-TrkB signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway" "42" "0" "1.091" "1.164" "1.041" "1.208" "1.030" "1.224" "1.265" "1.306" "1.848" "112.5" "122.8" "131.0" "117.1" "136.0" "115.9" "137.8" "142.4" "146.9" "208.0" "" "" "" "" "" "" "" "" "" "" "99.8" "101.7" "114.3" "87.6" "113.4" "106.5" "116.4" "117.7" "134.8" "208.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "High" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.000" "False" "18.522" "19" "4" "4" "4" "270" "30.0" "7.69" "17.06" "4" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "TP53 Regulates Metabolic Genes" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "3" "0" "0.949" "0.977" "0.956" "0.861" "0.902" "1.188" "1.109" "1.060" "2.842" "361.4" "342.9" "353.0" "345.5" "311.1" "326.0" "429.5" "401.0" "383.3" "1027.2" "" "" "" "" "" "" "" "" "" "" "320.5" "284.0" "308.0" "258.4" "259.4" "299.5" "363.0" "331.4" "351.5" "1027.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1899835700088576048" "False" "High" "IsMasterProtein" "O14656" "Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1" "0.000" "False" "18.494" "10" "3" "3" "3" "332" "37.8" "6.99" "12.38" "3" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "1861" "ENSG00000136827" "TOR1A" "B2RB58; hsa:1861; O14656; Q53Y64; Q96CA0" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "1.042" "1.092" "1.119" "1.100" "1.086" "1.222" "1.215" "1.113" "0.739" "417.7" "435.0" "455.9" "467.5" "459.5" "453.4" "510.5" "507.3" "465.0" "308.6" "" "" "" "" "" "" "" "" "" "" "370.4" "360.4" "397.8" "349.6" "383.2" "416.5" "431.5" "419.3" "426.4" "308.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864201792584752389" "False" "High" "IsMasterProtein" "Q03188" "Centromere protein C OS=Homo sapiens OX=9606 GN=CENPC PE=1 SV=2" "0.000" "False" "18.484" "5" "6" "8" "6" "943" "106.8" "9.39" "23.86" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11699, Pf15620, Pf15622" "1060" "ENSG00000145241" "CENPC" "hsa:1060; Q03188; Q6PIR0; Q8IW27; Q9P0M5" "Separation of Sister Chromatids; Deposition of new CENPA-containing nucleosomes at the centromere; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "0.943" "0.925" "1.006" "1.029" "0.876" "0.838" "0.998" "0.969" "0.660" "517.7" "488.3" "479.0" "520.7" "532.8" "453.5" "434.0" "516.7" "501.6" "341.7" "" "" "" "" "" "" "" "" "" "" "459.1" "404.5" "418.0" "389.4" "444.2" "416.6" "366.8" "427.1" "460.0" "341.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175952193399053833" "False" "High" "IsMasterProtein" "P50748" "Kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=KNTC1 PE=1 SV=1" "0.000" "False" "18.444" "3" "8" "10" "7" "2209" "250.6" "5.97" "27.87" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10493" "9735" "ENSG00000184445" "KNTC1" "A7E2C4; B3KSG2; hsa:9735; P50748" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.984" "0.823" "1.045" "0.890" "1.091" "1.004" "0.895" "0.820" "1.950" "711.6" "700.3" "585.6" "743.8" "633.0" "776.2" "714.4" "636.8" "583.2" "1387.4" "" "" "" "" "" "" "" "" "" "" "631.0" "580.1" "511.0" "556.3" "527.9" "713.0" "603.8" "526.3" "534.8" "1387.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "18.439" "12" "4" "4" "4" "423" "46.3" "8.13" "17.72" "4" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "0.919" "0.983" "0.924" "0.912" "0.933" "0.885" "0.664" "0.828" "4.335" "256.4" "235.5" "252.1" "236.9" "233.9" "239.2" "226.9" "170.3" "212.4" "1111.6" "" "" "" "" "" "" "" "" "" "" "227.4" "195.1" "220.0" "177.2" "195.0" "219.7" "191.8" "140.8" "194.8" "1111.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "717271239892975644" "False" "High" "IsMasterProtein" "Q9UK73" "Protein fem-1 homolog B OS=Homo sapiens OX=9606 GN=FEM1B PE=1 SV=1" "0.000" "False" "18.437" "7" "4" "4" "4" "627" "70.2" "6.61" "13.87" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf12796" "10116" "ENSG00000169018" "FEM1B" "hsa:10116; O43146; Q9UK73" "Neddylation" "" "1" "0" "1.024" "0.898" "1.201" "1.032" "1.044" "1.103" "0.933" "0.816" "0.790" "261.3" "267.6" "234.6" "313.8" "269.6" "272.7" "288.3" "243.9" "213.3" "206.3" "" "" "" "" "" "" "" "" "" "" "231.7" "221.7" "204.7" "234.7" "224.8" "250.5" "243.6" "201.6" "195.6" "206.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8246483793918857615" "False" "High" "IsMasterProtein" "Q9NVI7" "ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A PE=1 SV=2" "0.000" "False" "18.428" "7" "4" "4" "4" "634" "71.3" "8.98" "15.66" "4" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00004, Pf12037" "55210" "ENSG00000197785" "ATAD3A" "B3KPB3; D2K8Q1; G3V1I6; Q5SV23; Q8N275; Q96A50; Q9NVI7" "" "1p36 copy number variation syndrome" "1" "0" "0.958" "0.970" "0.935" "0.926" "0.945" "0.833" "0.881" "0.967" "0.323" "372.9" "357.3" "361.7" "348.5" "345.2" "352.5" "310.5" "328.4" "360.5" "120.6" "" "" "" "" "" "" "" "" "" "" "330.7" "296.0" "315.6" "260.7" "287.9" "323.8" "262.4" "271.5" "330.6" "120.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "High" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.000" "False" "18.418" "30" "5" "7" "5" "123" "14.5" "11.05" "23.09" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.925" "1.039" "0.987" "0.929" "0.773" "0.861" "0.917" "0.975" "0.745" "851.0" "787.0" "883.9" "840.3" "790.6" "657.6" "732.6" "780.6" "829.6" "634.2" "" "" "" "" "" "" "" "" "" "" "754.6" "651.9" "771.3" "628.4" "659.3" "604.1" "619.2" "645.2" "760.8" "634.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6159664741780628895" "False" "High" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "0.000" "False" "18.410" "11" "6" "6" "3" "495" "55.5" "8.27" "17.77" "6" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "1.173" "1.130" "0.968" "1.073" "1.009" "1.018" "0.876" "1.007" "3.317" "94.5" "110.9" "106.8" "91.5" "101.5" "95.4" "96.2" "82.8" "95.2" "313.6" "" "" "" "" "" "" "" "" "" "" "83.8" "91.8" "93.2" "68.4" "84.6" "87.6" "81.3" "68.4" "87.3" "313.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3689423794866279404" "False" "High" "IsMasterProtein" "Q8N8A2" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3" "0.000" "False" "18.386" "4" "3" "3" "1" "993" "107.5" "6.30" "14.02" "3" "" "" "" "Pf12796" "91526" "ENSG00000065413" "ANKRD44" "hsa:91526; Q53SL9; Q6P480; Q86VL5; Q8IZ72; Q8N8A2; Q9UFA4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412599355076663570" "False" "High" "IsMasterProtein" "Q8WV92" "MIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MITD1 PE=1 SV=1" "0.000" "False" "18.337" "17" "3" "3" "3" "249" "29.3" "8.00" "12.74" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04212, Pf16565" "129531" "ENSG00000158411" "MITD1" "hsa:129531; Q69YV0; Q8WV92" "" "TAR syndrome" "1" "0" "1.342" "0.997" "1.457" "1.334" "1.087" "1.498" "1.141" "0.994" "0.805" "81.8" "109.9" "81.6" "119.3" "109.2" "89.0" "122.6" "93.4" "81.4" "65.9" "" "" "" "" "" "" "" "" "" "" "72.6" "91.0" "71.2" "89.2" "91.0" "81.8" "103.6" "77.2" "74.6" "65.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-981252296573627161" "False" "High" "IsMasterProtein" "Q8NCN4" "E3 ubiquitin-protein ligase RNF169 OS=Homo sapiens OX=9606 GN=RNF169 PE=1 SV=2" "0.000" "False" "18.310" "5" "4" "4" "4" "708" "77.1" "9.10" "12.81" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13920" "254225" "ENSG00000166439" "RNF169" "hsa:254225; Q6N015; Q8NCN4" "" "" "0" "0" "1.112" "1.016" "1.117" "1.026" "0.827" "1.166" "0.981" "0.958" "1.261" "89.4" "99.4" "90.8" "99.9" "91.7" "73.9" "104.2" "87.6" "85.7" "112.7" "" "" "" "" "" "" "" "" "" "" "79.3" "82.4" "79.3" "74.7" "76.5" "67.9" "88.1" "72.4" "78.6" "112.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1613875613327361847" "False" "High" "IsMasterProtein" "Q96G25" "Mediator of RNA polymerase II transcription subunit 8 OS=Homo sapiens OX=9606 GN=MED8 PE=1 SV=2" "0.000" "False" "18.258" "15" "3" "3" "3" "268" "29.1" "7.44" "13.08" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10232" "112950" "ENSG00000159479" "MED8" "A9IZ91; A9IZ92; hsa:112950; Q5JUY8; Q96FQ4; Q96G25" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.000" "False" "18.217" "27" "4" "8" "4" "148" "16.6" "11.00" "26.98" "4" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "1.055" "0.991" "1.164" "1.088" "0.945" "1.113" "1.002" "0.940" "1.507" "491.0" "517.8" "486.6" "571.5" "534.1" "463.9" "546.7" "492.0" "461.5" "739.9" "" "" "" "" "" "" "" "" "" "" "435.4" "428.9" "424.6" "427.4" "445.4" "426.1" "462.0" "406.7" "423.2" "739.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274876564336853802" "False" "High" "IsMasterProtein" "Q01804" "OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4" "0.000" "False" "18.216" "6" "6" "6" "6" "1114" "124.0" "6.71" "21.10" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02338" "54726" "ENSG00000164164" "OTUD4" "B4DYS4; hsa:54726; Q01804; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6" "" "" "0" "0" "1.070" "0.961" "0.984" "0.921" "0.990" "0.975" "0.887" "0.952" "0.863" "580.5" "621.0" "557.9" "571.0" "534.5" "574.9" "566.1" "514.6" "552.8" "501.1" "" "" "" "" "" "" "" "" "" "" "514.8" "514.4" "486.8" "427.0" "445.7" "528.1" "478.4" "425.4" "507.0" "501.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8109670193418590883" "False" "High" "IsMasterProtein" "O14641" "Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1" "0.000" "False" "18.212" "4" "3" "3" "3" "736" "78.9" "6.02" "11.20" "3" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1856" "ENSG00000004975" "DVL2" "D3DTN3; hsa:1856; O14641; Q53XM0" "Asymmetric localization of PCP proteins; Degradation of DVL; RHO GTPases Activate Formins; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "29" "0" "1.335" "1.149" "1.359" "1.263" "1.263" "1.324" "0.759" "1.189" "9.682" "54.0" "72.2" "62.1" "73.4" "68.3" "68.3" "71.6" "41.0" "64.3" "523.2" "" "" "" "" "" "" "" "" "" "" "47.9" "59.8" "54.2" "54.9" "56.9" "62.7" "60.5" "33.9" "59.0" "523.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8654405548002230634" "False" "High" "IsMasterProtein" "Q49B96" "Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1" "0.000" "False" "18.154" "41" "4" "8" "4" "90" "10.4" "8.72" "27.38" "4" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf06747" "90639" "ENSG00000240230" "COX19" "A4FTX0; hsa:90639; Q49B96" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Mitochondrial protein import" "Mitochondrial complex IV assembly" "5" "0" "1.003" "1.016" "1.019" "1.037" "1.008" "1.021" "1.080" "0.974" "0.745" "1011.6" "1015.1" "1028.3" "1030.5" "1049.2" "1019.7" "1033.3" "1092.2" "985.5" "753.4" "" "" "" "" "" "" "" "" "" "" "897.1" "840.8" "897.3" "770.7" "874.9" "936.7" "873.3" "902.8" "903.9" "753.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7060921209574590531" "False" "High" "IsMasterProtein" "Q01780" "Exosome complex component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2" "0.000" "False" "18.148" "4" "3" "4" "3" "885" "100.8" "8.46" "10.73" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00570, Pf01612, Pf08066" "5394" "ENSG00000171824" "EXOSC10" "B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1297378894876740813" "False" "High" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "0.000" "False" "18.144" "18" "5" "5" "5" "277" "32.0" "8.66" "17.99" "5" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Purine salvage" "Genetic causes of porto-sinusoidal vascular disease" "2" "0" "1.017" "1.017" "1.141" "1.177" "1.095" "1.061" "1.152" "1.055" "0.672" "270.8" "275.4" "275.3" "308.8" "318.8" "296.6" "287.3" "311.9" "285.7" "181.9" "" "" "" "" "" "" "" "" "" "" "240.1" "228.2" "240.2" "231.0" "265.9" "272.5" "242.8" "257.8" "262.0" "181.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7618289525843205014" "False" "High" "IsMasterProtein" "Q7L8W6" "Diphthine--ammonia ligase OS=Homo sapiens OX=9606 GN=DPH6 PE=1 SV=3" "0.000" "False" "18.124" "18" "4" "4" "4" "267" "30.3" "5.40" "15.51" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01902" "89978" "ENSG00000134146" "DPH6" "B3KWG1; hsa:89978; Q7L8W6; Q96HJ6" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.087" "1.004" "1.149" "1.033" "1.067" "1.055" "0.938" "0.921" "1.644" "237.2" "257.7" "238.1" "272.6" "244.9" "253.2" "250.2" "222.4" "218.5" "390.0" "" "" "" "" "" "" "" "" "" "" "210.3" "213.5" "207.8" "203.9" "204.2" "232.5" "211.4" "183.8" "200.4" "390.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934438525806986251" "False" "High" "IsMasterProtein" "Q7Z7K0" "COX assembly mitochondrial protein homolog OS=Homo sapiens OX=9606 GN=CMC1 PE=1 SV=1" "0.000" "False" "18.095" "40" "4" "5" "4" "106" "12.5" "8.63" "19.75" "4" "" "mitochondrion" "other molecular function" "Pf08583" "152100" "ENSG00000187118" "CMC1" "hsa:152100; Q68DJ7; Q7Z7K0" "" "Mitochondrial complex IV assembly" "1" "0" "0.968" "1.124" "0.964" "1.045" "1.213" "0.993" "1.129" "1.134" "0.483" "530.6" "513.4" "596.4" "511.3" "554.3" "643.5" "526.8" "599.2" "601.6" "256.4" "" "" "" "" "" "" "" "" "" "" "470.5" "425.3" "520.4" "382.4" "462.2" "591.1" "445.2" "495.3" "551.8" "256.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5303653638395268189" "False" "High" "IsMasterProtein" "Q16633" "POU domain class 2-associating factor 1 OS=Homo sapiens OX=9606 GN=POU2AF1 PE=1 SV=1" "0.000" "False" "18.087" "12" "2" "5" "2" "256" "27.4" "4.94" "20.04" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09310" "5450" "ENSG00000110777" "POU2AF1" "B2R8Z9; hsa:5450; Q14983; Q16633" "" "" "0" "0" "1.093" "1.108" "1.069" "1.210" "1.106" "0.900" "0.875" "0.847" "0.740" "787.7" "860.6" "872.8" "842.0" "953.0" "871.2" "709.2" "689.0" "667.2" "583.1" "" "" "" "" "" "" "" "" "" "" "698.5" "712.9" "761.5" "629.7" "794.7" "800.3" "599.4" "569.5" "611.9" "583.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3487009987400899106" "False" "High" "IsMasterProtein" "P13051" "Uracil-DNA glycosylase OS=Homo sapiens OX=9606 GN=UNG PE=1 SV=2" "0.000" "False" "18.081" "14" "3" "3" "3" "313" "34.6" "9.32" "13.48" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;nucleus" "translation activity;nucleic acid binding activity;other molecular function" "Pf03167" "7374" "ENSG00000076248" "UNG" "A8K5M6; B2R8Y1; hsa:7374; O00637; O00719; P13051; Q93028" "Chromatin modifications during the maternal to zygotic transition (MZT)" "Base excision repair; DNA repair pathways, full network" "3" "0" "0.905" "1.108" "0.787" "0.915" "0.923" "1.095" "1.112" "1.242" "1.718" "42.4" "38.4" "47.0" "33.4" "38.8" "39.1" "46.4" "47.2" "52.7" "72.9" "" "" "" "" "" "" "" "" "" "" "37.6" "31.8" "41.0" "25.0" "32.4" "36.0" "39.3" "39.0" "48.3" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "High" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.000" "False" "18.070" "15" "6" "6" "6" "427" "47.4" "8.41" "15.35" "6" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "0.814" "1.203" "0.900" "0.777" "0.873" "0.794" "0.520" "0.681" "5.972" "237.0" "193.0" "285.1" "213.3" "184.2" "206.9" "188.1" "123.2" "161.4" "1415.5" "" "" "" "" "" "" "" "" "" "" "210.2" "159.9" "248.8" "159.6" "153.6" "190.1" "159.0" "101.9" "148.0" "1415.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246838135834817893" "False" "High" "IsMasterProtein" "O75362" "Zinc finger protein 217 OS=Homo sapiens OX=9606 GN=ZNF217 PE=1 SV=1" "0.000" "False" "18.046" "4" "4" "6" "4" "1048" "115.2" "8.48" "21.02" "4" "other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7764" "ENSG00000171940" "ZNF217" "E1P5Y6; hsa:7764; O75362; Q14DB8" "Estrogen-dependent gene expression" "" "1" "0" "0.829" "0.817" "0.981" "0.735" "0.730" "0.740" "0.797" "0.761" "1.047" "389.5" "323.1" "318.1" "382.0" "286.4" "284.2" "288.3" "310.5" "296.5" "407.8" "" "" "" "" "" "" "" "" "" "" "345.4" "267.6" "277.5" "285.7" "238.8" "261.1" "243.7" "256.6" "271.9" "407.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054050603788689952" "False" "High" "IsMasterProtein" "Q86YV0" "RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2" "0.000" "False" "18.046" "5" "4" "5" "4" "1011" "111.8" "8.75" "18.95" "4" "other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00616" "64926" "ENSG00000105122" "RASAL3" "hsa:64926; Q86YV0; Q8N2T9; Q9H735" "Regulation of RAS by GAPs" "Ras signaling" "2" "0" "0.946" "0.948" "1.140" "0.777" "0.926" "0.912" "0.639" "1.100" "4.349" "134.4" "127.1" "127.3" "153.1" "104.4" "124.4" "122.6" "85.8" "147.8" "584.3" "" "" "" "" "" "" "" "" "" "" "119.1" "105.3" "111.1" "114.5" "87.0" "114.3" "103.6" "71.0" "135.5" "584.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "High" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.000" "False" "18.041" "44" "3" "3" "3" "124" "13.6" "7.34" "16.65" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "Neutrophil degranulation; Amino acids regulate mTORC1; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; MAP2K and MAPK activation; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "13" "0" "1.131" "1.203" "1.086" "1.259" "1.273" "1.303" "1.204" "1.556" "0.786" "104.2" "117.8" "125.3" "113.1" "131.2" "132.6" "135.8" "125.4" "162.0" "81.8" "" "" "" "" "" "" "" "" "" "" "92.4" "97.6" "109.4" "84.6" "109.4" "121.8" "114.7" "103.7" "148.6" "81.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649705542655534815" "False" "High" "IsMasterProtein" "Q8N573" "Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2" "0.000" "False" "18.040" "5" "4" "4" "3" "874" "97.9" "5.47" "13.86" "4" "stress response;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01476, Pf07534" "55074" "ENSG00000164830" "OXR1" "A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; hsa:55074; Q3LIB5; Q6ZVK9; Q8N573; Q8N8V0; Q9H266; Q9NWC7" "" "" "0" "0" "1.051" "1.086" "1.215" "1.202" "0.962" "1.136" "1.020" "0.960" "0.720" "98.0" "103.0" "106.4" "119.1" "117.8" "94.3" "111.4" "100.0" "94.1" "70.6" "" "" "" "" "" "" "" "" "" "" "86.9" "85.3" "92.9" "89.1" "98.2" "86.6" "94.1" "82.6" "86.3" "70.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6810289511595074622" "False" "High" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "0.000" "False" "18.031" "6" "3" "4" "3" "541" "56.6" "5.48" "18.67" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "RHOQ GTPase cycle; RAC1 GTPase cycle; RHOH GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Amino acid transport across the plasma membrane" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "11" "0" "1.083" "0.944" "1.015" "1.108" "1.055" "1.022" "1.038" "1.350" "0.638" "823.6" "892.3" "777.3" "836.4" "912.3" "869.0" "841.6" "854.6" "1112.1" "525.4" "" "" "" "" "" "" "" "" "" "" "730.4" "739.1" "678.2" "625.5" "760.7" "798.3" "711.3" "706.4" "1019.9" "525.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7524352490741382419" "False" "High" "IsMasterProtein" "O14972" "Vacuolar protein sorting-associated protein 26C OS=Homo sapiens OX=9606 GN=VPS26C PE=1 SV=1" "0.000" "False" "18.004" "16" "3" "3" "3" "297" "33.0" "7.68" "14.63" "3" "transport" "other cytoplasmic organelle" "" "Pf03643" "10311" "ENSG00000157538" "VPS26C" "B2R6T8; B7Z6B1; D3DSH4; hsa:10311; O14972; Q2TAY6" "" "" "0" "0" "1.182" "1.030" "0.978" "1.093" "1.015" "1.254" "1.018" "1.098" "1.542" "173.4" "205.0" "178.6" "169.6" "189.5" "175.9" "217.5" "176.5" "190.4" "267.4" "" "" "" "" "" "" "" "" "" "" "153.8" "169.8" "155.9" "126.8" "158.0" "161.6" "183.8" "145.9" "174.7" "267.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "High" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.000" "False" "18.002" "6" "5" "7" "5" "770" "86.8" "6.67" "22.47" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.123" "1.084" "1.165" "1.125" "0.997" "1.100" "1.048" "0.960" "1.886" "212.6" "238.7" "230.3" "247.6" "239.2" "212.0" "233.8" "222.7" "204.1" "401.0" "" "" "" "" "" "" "" "" "" "" "188.5" "197.7" "201.0" "185.2" "199.4" "194.8" "197.6" "184.1" "187.2" "401.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.000" "False" "17.988" "12" "4" "4" "4" "375" "41.9" "5.44" "16.54" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "4" "0" "1.008" "0.700" "0.801" "0.668" "0.545" "0.536" "0.685" "0.726" "0.555" "237.2" "239.2" "166.1" "190.0" "158.5" "129.3" "127.1" "162.6" "172.3" "131.7" "" "" "" "" "" "" "" "" "" "" "210.4" "198.1" "144.9" "142.1" "132.2" "118.8" "107.4" "134.4" "158.1" "131.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2592776449693665757" "False" "High" "IsMasterProtein" "O95455" "dTDP-D-glucose 4,6-dehydratase OS=Homo sapiens OX=9606 GN=TGDS PE=1 SV=1" "0.000" "False" "17.962" "18" "7" "7" "6" "350" "40.2" "6.60" "13.95" "7" "other metabolic processes" "" "other molecular function" "Pf16363" "23483" "ENSG00000088451" "TGDS" "hsa:23483; O95455; Q05DQ3; Q2TU31; Q5T3Z2; Q9H1T9" "" "" "0" "0" "0.759" "0.995" "0.903" "0.884" "0.878" "0.915" "0.888" "0.784" "0.540" "519.5" "394.3" "516.9" "469.2" "459.4" "456.1" "475.1" "461.2" "407.5" "280.5" "" "" "" "" "" "" "" "" "" "" "460.6" "326.6" "451.0" "350.9" "383.1" "419.0" "401.6" "381.2" "373.7" "280.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890760883318771042" "False" "High" "IsMasterProtein" "Q15653" "NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2" "0.000" "False" "17.951" "11" "3" "3" "3" "356" "37.7" "4.84" "11.47" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00023, Pf13637" "4793" "ENSG00000104825; ENSG00000282905" "NFKBIB" "A8K3F4; hsa:4793; Q15653; Q96BJ7" "Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Apoptosis; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Toll-like receptor signaling pathway" "16" "0" "1.089" "1.005" "1.112" "1.035" "0.995" "0.965" "0.724" "0.935" "5.781" "158.3" "172.4" "159.1" "176.0" "163.8" "157.5" "152.8" "114.6" "148.1" "915.3" "" "" "" "" "" "" "" "" "" "" "140.4" "142.8" "138.8" "131.6" "136.6" "144.7" "129.1" "94.7" "135.8" "915.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835472215069796756" "False" "High" "IsMasterProtein" "Q9Y692" "Glucocorticoid modulatory element-binding protein 1 OS=Homo sapiens OX=9606 GN=GMEB1 PE=1 SV=2" "0.000" "False" "17.932" "10" "3" "3" "3" "573" "62.6" "4.83" "12.39" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "10691" "ENSG00000162419" "GMEB1" "B1AT48; hsa:10691; Q9NWH1; Q9UKD0; Q9Y692" "" "2q37 copy number variation syndrome" "1" "0" "1.019" "1.076" "1.094" "1.059" "0.993" "1.026" "0.922" "1.128" "2.743" "221.4" "225.5" "238.3" "242.2" "234.4" "220.0" "227.2" "204.3" "249.8" "607.5" "" "" "" "" "" "" "" "" "" "" "196.4" "186.8" "207.9" "181.1" "195.5" "202.1" "192.1" "168.8" "229.1" "607.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4124331423707824926" "False" "High" "IsMasterProtein" "Q8N4S0" "Coiled-coil domain-containing protein 82 OS=Homo sapiens OX=9606 GN=CCDC82 PE=1 SV=2" "0.000" "False" "17.925" "8" "4" "4" "4" "544" "64.0" "5.01" "14.87" "4" "" "nucleus" "" "Pf13846, Pf13926" "79780" "ENSG00000149231" "CCDC82" "B3KPU7; hsa:79780; Q8N4S0; Q8WV71; Q9H2Q5; Q9H5E3" "" "" "0" "0" "0.935" "0.962" "0.904" "0.926" "1.002" "0.930" "1.016" "0.972" "0.864" "662.1" "619.2" "636.7" "598.8" "613.2" "663.2" "615.7" "672.5" "643.8" "572.2" "" "" "" "" "" "" "" "" "" "" "587.1" "512.9" "555.5" "447.8" "511.3" "609.2" "520.3" "555.9" "590.4" "572.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5155041473924721713" "False" "High" "IsMasterProtein" "P48454" "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP3CC PE=1 SV=3" "0.000" "False" "17.910" "10" "5" "10" "2" "512" "58.1" "6.98" "22.16" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00149" "5533" "ENSG00000120910" "PPP3CC" "B4DRT5; hsa:5533; P48454; Q9BSS6; Q9H4M5" "DARPP-32 events; Activation of BAD and translocation to mitochondria" "Energy metabolism; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186316132273188222" "False" "High" "IsMasterProtein" "Q92538" "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=3" "0.000" "False" "17.859" "3" "4" "4" "4" "1860" "206.4" "5.73" "13.53" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf12783" "8729" "ENSG00000107862" "GBF1" "A0A7P0RGV0; hsa:8729; Q149P0; Q149P1; Q5VXX3; Q92538; Q96CK6; Q96HZ3; Q9H473" "VxPx cargo-targeting to cilium; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; trans-Golgi Network Vesicle Budding" "" "4" "0" "0.924" "0.677" "0.828" "0.921" "0.653" "0.926" "0.180" "1.073" "10.934" "53.4" "49.3" "36.2" "44.2" "49.1" "34.8" "49.4" "9.6" "57.3" "583.7" "" "" "" "" "" "" "" "" "" "" "47.3" "40.8" "31.6" "33.1" "41.0" "32.0" "41.8" "8.0" "52.5" "583.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243510255652215024" "False" "High" "IsMasterProtein" "Q9Y448" "Small kinetochore-associated protein OS=Homo sapiens OX=9606 GN=KNSTRN PE=1 SV=2" "0.000" "False" "17.803" "13" "4" "4" "4" "316" "35.4" "6.30" "14.06" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "90417" "ENSG00000128944" "KNSTRN" "B4DXA7; hsa:90417; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4; Q9Y448" "" "Leukocyte-intrinsic Hippo pathway functions" "1" "0" "0.993" "0.947" "1.021" "1.028" "0.997" "0.919" "0.789" "0.878" "2.218" "428.3" "425.4" "405.7" "437.4" "440.3" "427.1" "393.8" "338.0" "376.1" "949.9" "" "" "" "" "" "" "" "" "" "" "379.8" "352.4" "354.0" "327.1" "367.1" "392.3" "332.8" "279.4" "344.9" "949.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5598137855594202811" "False" "High" "IsMasterProtein" "Q9Y6G3" "Large ribosomal subunit protein mL42 OS=Homo sapiens OX=9606 GN=MRPL42 PE=1 SV=1" "0.000" "False" "17.771" "27" "2" "2" "2" "142" "16.7" "8.35" "12.14" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10210" "28977" "ENSG00000198015" "MRPL42" "hsa:28977; Q6FID1; Q96Q48; Q9P0S1; Q9Y6G3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.075" "0.870" "0.759" "1.156" "0.901" "0.977" "1.038" "0.922" "1.036" "137.5" "147.7" "119.5" "104.4" "158.9" "123.8" "134.3" "142.6" "126.7" "142.4" "" "" "" "" "" "" "" "" "" "" "121.9" "122.4" "104.3" "78.1" "132.5" "113.7" "113.5" "117.9" "116.2" "142.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6899043111177724007" "False" "High" "IsMasterProtein" "Q15208" "Serine/threonine-protein kinase 38 OS=Homo sapiens OX=9606 GN=STK38 PE=1 SV=1" "0.000" "False" "17.766" "10" "4" "4" "4" "465" "54.2" "7.15" "18.28" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "11329" "ENSG00000112079" "STK38" "hsa:11329; Q15208; Q503A1" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "Interactome of polycomb repressive complex 2 (PRC2)" "3" "0" "1.045" "1.012" "1.491" "1.115" "0.990" "1.097" "0.877" "1.019" "3.255" "180.8" "188.9" "182.9" "269.6" "201.5" "179.0" "198.2" "158.5" "184.3" "588.5" "" "" "" "" "" "" "" "" "" "" "160.3" "156.5" "159.6" "201.6" "168.0" "164.4" "167.5" "131.0" "169.0" "588.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "High" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.000" "False" "17.761" "28" "4" "4" "4" "160" "19.0" "5.20" "16.50" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.927" "0.833" "0.880" "0.757" "0.840" "0.801" "0.818" "0.902" "2.061" "382.8" "355.0" "318.7" "336.8" "289.7" "321.5" "306.4" "313.3" "345.3" "788.8" "" "" "" "" "" "" "" "" "" "" "339.4" "294.0" "278.0" "251.9" "241.6" "295.3" "259.0" "259.0" "316.7" "788.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5843152145544884275" "False" "High" "IsMasterProtein" "Q6KC79" "Nipped-B-like protein OS=Homo sapiens OX=9606 GN=NIPBL PE=1 SV=2" "0.000" "False" "17.759" "2" "5" "5" "5" "2804" "315.9" "7.91" "15.70" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12765, Pf12830" "25836" "ENSG00000164190" "NIPBL" "hsa:25836; Q6KC79; Q6KCD6; Q6N080; Q6ZT92; Q7Z2E6; Q8N4M5; Q9Y6Y3; Q9Y6Y4" "Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "3" "0" "0.942" "0.824" "0.922" "0.847" "0.870" "0.911" "0.848" "0.857" "0.753" "384.0" "361.7" "316.3" "354.2" "325.3" "334.0" "349.8" "325.8" "329.2" "289.2" "" "" "" "" "" "" "" "" "" "" "340.5" "299.6" "276.0" "264.9" "271.2" "306.8" "295.6" "269.3" "302.0" "289.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "17.756" "30" "5" "6" "5" "152" "17.7" "10.99" "19.39" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.934" "0.887" "0.993" "0.913" "0.755" "0.825" "0.788" "0.843" "1.847" "480.9" "449.3" "426.6" "477.6" "439.2" "363.0" "396.6" "378.8" "405.3" "888.1" "" "" "" "" "" "" "" "" "" "" "426.5" "372.2" "372.2" "357.2" "366.2" "333.5" "335.2" "313.1" "371.7" "888.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4884717818161655002" "False" "High" "IsMasterProtein" "Q9H4L5" "Oxysterol-binding protein-related protein 3 OS=Homo sapiens OX=9606 GN=OSBPL3 PE=1 SV=1" "0.000" "False" "17.739" "6" "4" "4" "4" "887" "101.2" "6.87" "12.82" "4" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "26031" "ENSG00000070882" "OSBPL3" "A4D167; A4D168; A4D169; A4D170; A4D171; A4D172; B8ZZ79; B8ZZP0; hsa:26031; O14591; O43357; O43358; Q8N702; Q8N703; Q8N704; Q8NFH0; Q8NFH1; Q8NI12; Q8NI13; Q9BZF4; Q9H4L5; Q9UED6" "Synthesis of bile acids and bile salts" "Orexin receptor pathway" "2" "0" "0.748" "0.893" "0.750" "0.939" "0.864" "0.943" "0.010" "0.825" "31.099" "29.5" "22.1" "26.3" "22.1" "27.7" "25.5" "27.8" "0.0" "24.3" "917.2" "" "" "" "" "" "" "" "" "" "" "26.2" "18.3" "23.0" "16.5" "23.1" "23.4" "23.5" "0.0" "22.3" "917.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5902665754527388004" "False" "High" "IsMasterProtein" "Q969R8" "KICSTOR complex protein ITFG2 OS=Homo sapiens OX=9606 GN=ITFG2 PE=1 SV=1" "0.000" "False" "17.734" "9" "4" "5" "4" "447" "49.3" "5.22" "17.25" "4" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf15907" "55846" "ENSG00000111203" "ITFG2" "A8K4Z5; D3DUQ2; hsa:55846; Q6PKU5; Q969R8; Q96SX6" "Amino acids regulate mTORC1" "" "1" "0" "0.955" "0.993" "1.062" "0.945" "0.994" "1.162" "1.054" "0.940" "0.688" "182.1" "173.8" "180.9" "193.4" "172.0" "180.9" "211.6" "192.0" "171.2" "125.2" "" "" "" "" "" "" "" "" "" "" "161.5" "144.0" "157.8" "144.6" "143.4" "166.2" "178.9" "158.7" "157.0" "125.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009101809611603487" "False" "High" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "0.000" "False" "17.731" "9" "5" "5" "5" "608" "68.4" "7.65" "13.45" "5" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "Nonhomologous End-Joining (NHEJ)" "" "1" "0" "0.976" "0.910" "0.908" "0.853" "1.065" "0.857" "0.594" "0.950" "5.204" "297.6" "290.4" "270.8" "270.2" "254.0" "317.0" "255.1" "176.9" "282.7" "1548.7" "" "" "" "" "" "" "" "" "" "" "263.9" "240.5" "236.3" "202.1" "211.8" "291.2" "215.6" "146.2" "259.3" "1548.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9085991407022296267" "False" "High" "IsMasterProtein" "P01920" "HLA class II histocompatibility antigen, DQ beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DQB1 PE=1 SV=2" "0.000" "False" "17.716" "17" "4" "5" "3" "261" "30.0" "7.25" "17.84" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3119" "ENSG00000225824; ENSG00000231286; ENSG00000233209" "HLA-DQB1" "A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7; B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35; C8ZL52; C8ZLJ8; C8ZLJ9; C9DRQ3; hsa:3119; O19708; O19713; O19724; O62861; O78046; O78221; O78223; O98034; O98201; P01917; P01918; P01919; P01920; P03992; P05537; P79482; P79526; P79544; P79551; Q08GC8; Q09035; Q0E4V9; Q1M312; Q29731; Q29877; Q29884; Q29915; Q29966; Q2P9N3; Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081; Q30082; Q30083; Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5; Q53I44; Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1; Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3; Q9BD17; Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection" "8" "0" "1.055" "1.107" "1.169" "0.961" "1.035" "1.171" "0.965" "1.083" "0.676" "131.5" "138.8" "145.6" "153.7" "126.5" "136.1" "154.1" "127.0" "142.4" "88.9" "" "" "" "" "" "" "" "" "" "" "116.6" "115.0" "127.1" "115.0" "105.4" "125.0" "130.2" "105.0" "130.6" "88.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6896293366325971592" "False" "High" "IsMasterProtein" "Q8WWK9" "Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1" "0.000" "False" "17.686" "4" "3" "5" "3" "683" "76.9" "9.41" "19.70" "3" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "" "Pf15297" "26586" "ENSG00000136108" "CKAP2" "A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4" "" "" "0" "0" "1.030" "0.865" "0.923" "0.845" "0.844" "0.928" "0.963" "1.111" "1.122" "804.5" "828.6" "696.2" "742.2" "679.5" "679.3" "746.2" "774.7" "894.0" "903.0" "" "" "" "" "" "" "" "" "" "" "713.4" "686.4" "607.5" "555.1" "566.6" "624.1" "630.7" "640.4" "819.9" "903.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572306403840384650" "False" "High" "IsMasterProtein" "O75208" "Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1" "0.000" "False" "17.683" "12" "3" "4" "3" "318" "35.5" "5.94" "22.53" "3" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08511, Pf21392" "57017" "ENSG00000088682" "COQ9" "A8K3L2; hsa:57017; O75208; Q7L5V7; Q7Z5T6; Q8NBL4; Q9NTJ2; Q9P056" "Ubiquinol biosynthesis" "" "1" "0" "0.953" "0.959" "0.891" "1.029" "0.941" "0.960" "0.941" "1.026" "0.667" "523.1" "498.4" "501.5" "465.9" "538.1" "492.1" "502.1" "492.0" "536.5" "348.9" "" "" "" "" "" "" "" "" "" "" "463.8" "412.8" "437.6" "348.4" "448.7" "452.0" "424.3" "406.7" "492.0" "348.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1176830711489117496" "False" "High" "IsMasterProtein" "Q7L1V2" "Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1" "0.000" "False" "17.681" "9" "4" "4" "4" "547" "59.2" "6.29" "15.20" "4" "transport;other biological processes" "other cytoplasmic organelle;other cell component" "" "Pf19036, Pf19037, Pf19038" "22879" "ENSG00000103111" "MON1B" "B4DDZ0; hsa:22879; O94949; Q7L1V2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.005" "0.929" "1.082" "1.031" "0.997" "1.045" "0.986" "0.836" "1.109" "483.5" "485.7" "449.2" "522.9" "498.5" "481.9" "505.4" "476.6" "404.3" "536.0" "" "" "" "" "" "" "" "" "" "" "428.7" "402.3" "391.9" "391.0" "415.7" "442.7" "427.2" "394.0" "370.8" "536.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833705581656825044" "False" "High" "IsMasterProtein" "Q96RT1" "Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2" "0.000" "False" "17.649" "4" "6" "6" "6" "1412" "158.2" "5.50" "17.60" "6" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00595, Pf13855" "55914" "ENSG00000112851" "ERBIN" "A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma" "26" "0" "0.978" "0.971" "1.018" "0.730" "0.827" "0.731" "0.833" "0.869" "1.262" "163.6" "159.9" "158.9" "166.5" "119.3" "135.2" "119.5" "136.2" "142.2" "206.5" "" "" "" "" "" "" "" "" "" "" "145.0" "132.4" "138.6" "124.5" "99.5" "124.2" "101.0" "112.6" "130.4" "206.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5046480723636324863" "False" "High" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "0.000" "False" "17.641" "10" "3" "4" "3" "301" "33.2" "8.82" "12.33" "3" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "Q96FD2; Q9Y314" "NOSIP mediated eNOS trafficking" "" "1" "0" "1.152" "1.014" "1.145" "0.957" "1.229" "0.995" "0.459" "0.951" "11.061" "101.4" "116.9" "102.9" "116.2" "97.0" "124.7" "100.9" "46.5" "96.5" "1121.9" "" "" "" "" "" "" "" "" "" "" "89.9" "96.8" "89.8" "86.9" "80.9" "114.5" "85.3" "38.5" "88.5" "1121.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4398789072412591486" "False" "High" "IsMasterProtein" "Q14249" "Endonuclease G, mitochondrial OS=Homo sapiens OX=9606 GN=ENDOG PE=1 SV=4" "0.000" "False" "17.634" "19" "5" "6" "5" "297" "32.6" "9.50" "19.87" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01223" "2021" "ENSG00000167136" "ENDOG" "hsa:2021; Q14249; Q5T281; Q9BSP2" "" "Nanomaterial induced apoptosis; Acute viral myocarditis" "2" "0" "1.076" "0.955" "0.893" "0.987" "0.983" "0.849" "0.818" "0.798" "0.941" "239.0" "257.3" "228.3" "213.4" "235.9" "235.1" "202.9" "195.6" "190.7" "224.9" "" "" "" "" "" "" "" "" "" "" "212.0" "213.1" "199.2" "159.6" "196.7" "216.0" "171.5" "161.7" "174.9" "224.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6528342238616596443" "False" "High" "IsMasterProtein" "Q92542" "Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2" "0.000" "False" "17.629" "6" "4" "6" "4" "709" "78.4" "5.99" "18.28" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05450, Pf18266" "23385" "ENSG00000162736" "NCSTN" "hsa:23385; Q5T207; Q5T208; Q86VV5; Q92542" "Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3" "Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Notch signaling pathway" "20" "0" "0.846" "0.853" "0.907" "0.778" "0.624" "0.647" "0.835" "1.088" "0.653" "78.1" "66.1" "66.6" "70.8" "60.8" "48.7" "50.5" "65.2" "85.0" "51.0" "" "" "" "" "" "" "" "" "" "" "69.2" "54.7" "58.1" "53.0" "50.7" "44.8" "42.7" "53.9" "77.9" "51.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1395564513229487982" "False" "High" "IsMasterProtein" "O94826" "Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1" "0.000" "False" "17.621" "8" "6" "6" "6" "608" "67.4" "7.12" "20.24" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00515, Pf13181" "9868" "ENSG00000154174" "TOMM70" "D3DN48; hsa:9868; O94826" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "9" "0" "1.030" "0.868" "0.980" "0.908" "0.980" "0.919" "0.494" "0.860" "8.776" "381.4" "392.9" "331.2" "373.8" "346.5" "373.7" "350.4" "188.3" "328.1" "3347.5" "" "" "" "" "" "" "" "" "" "" "338.3" "325.5" "289.0" "279.6" "289.0" "343.3" "296.1" "155.6" "300.9" "3347.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5954226143684266914" "False" "High" "IsMasterProtein" "P10398" "Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2" "0.000" "False" "17.606" "8" "5" "5" "2" "606" "67.5" "9.01" "16.96" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "369" "ENSG00000078061" "ARAF" "hsa:369; P07557; P10398; Q5H9B2; Q5H9B3" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway" "33" "0" "0.916" "0.890" "0.899" "0.977" "0.831" "1.038" "0.712" "1.216" "7.261" "92.7" "84.9" "82.5" "83.3" "90.6" "77.0" "96.2" "66.0" "112.8" "673.1" "" "" "" "" "" "" "" "" "" "" "82.2" "70.3" "72.0" "62.3" "75.5" "70.7" "81.3" "54.6" "103.4" "673.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "17.597" "54" "5" "14" "5" "103" "11.6" "5.27" "37.93" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "0.956" "1.012" "0.916" "0.955" "1.056" "0.959" "0.997" "1.007" "0.404" "1817.7" "1738.5" "1838.8" "1665.4" "1736.0" "1920.2" "1742.6" "1812.0" "1831.1" "735.2" "" "" "" "" "" "" "" "" "" "" "1611.9" "1440.1" "1604.4" "1245.5" "1447.6" "1763.9" "1472.8" "1497.7" "1679.4" "735.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338672527715775280" "False" "High" "IsMasterProtein" "Q8IWL3" "Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3" "0.000" "False" "17.576" "21" "5" "6" "5" "235" "27.4" "7.69" "24.71" "5" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf07743, Pf18256" "150274" "ENSG00000100209" "HSCB" "hsa:150274; Q8IWL3; Q9BWS7" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "3" "0" "1.088" "0.953" "1.057" "0.966" "1.158" "1.002" "0.989" "0.940" "0.997" "226.3" "246.2" "215.7" "239.1" "218.5" "262.1" "226.8" "223.8" "212.6" "225.7" "" "" "" "" "" "" "" "" "" "" "200.6" "203.9" "188.2" "178.8" "182.2" "240.7" "191.7" "185.0" "195.0" "225.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421733537835387635" "False" "High" "IsMasterProtein" "Q9NPE2" "Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2" "0.000" "False" "17.558" "11" "3" "4" "3" "291" "32.4" "9.10" "15.84" "3" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf06413" "51335" "ENSG00000182768" "NGRN" "B2R6M8; hsa:51335; Q4V9L7; Q9HBL4; Q9NPE2" "" "" "0" "0" "0.967" "0.958" "1.020" "1.052" "0.963" "0.918" "0.948" "0.947" "0.587" "466.0" "450.7" "446.7" "475.5" "490.5" "448.9" "427.9" "441.8" "441.3" "273.4" "" "" "" "" "" "" "" "" "" "" "413.3" "373.4" "389.7" "355.6" "409.0" "412.4" "361.7" "365.2" "404.8" "273.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4329245545062110439" "False" "High" "IsMasterProtein" "Q9NQ50" "Large ribosomal subunit protein mL40 OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" "0.000" "False" "17.555" "21" "4" "6" "4" "206" "24.5" "9.63" "25.30" "4" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf09812" "64976" "ENSG00000185608" "MRPL40" "B3KVZ7; hsa:64976; O95134; Q9NQ50" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "22q11.2 copy number variation syndrome" "4" "0" "0.945" "0.923" "0.921" "1.049" "0.980" "0.953" "0.825" "0.942" "0.857" "169.6" "160.2" "156.5" "156.2" "177.8" "166.2" "161.7" "139.9" "159.7" "145.3" "" "" "" "" "" "" "" "" "" "" "150.4" "132.7" "136.6" "116.8" "148.3" "152.7" "136.6" "115.6" "146.5" "145.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5356440792729817096" "False" "High" "IsMasterProtein" "Q5VZ89" "DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3" "0.000" "False" "17.518" "2" "3" "4" "3" "1909" "212.6" "6.83" "15.89" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "55667" "ENSG00000137145" "DENND4C" "A2A3R1; A2A3R2; A2A3R3; A2A3R9; hsa:55667; Q5VZ89; Q6AI48; Q6ZUB3; Q8NCY7; Q9H6N4; Q9NUT1; Q9NWA5; Q9NWT3; R4GN35; R4GNB2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.947" "0.875" "0.959" "0.883" "0.830" "1.050" "0.935" "0.966" "3.154" "97.4" "92.2" "85.3" "93.4" "86.0" "80.8" "102.3" "91.0" "94.1" "307.2" "" "" "" "" "" "" "" "" "" "" "86.4" "76.4" "74.4" "69.9" "71.7" "74.3" "86.5" "75.2" "86.3" "307.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951709946097313123" "False" "High" "IsMasterProtein" "P78362" "SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3" "0.000" "False" "17.482" "8" "6" "7" "4" "688" "77.5" "4.97" "17.71" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6733" "ENSG00000135250" "SRPK2" "A8MVX2; hsa:6733; O75220; O75221; P78362; Q6NUL0; Q6V1X2; Q8IYQ3" "Maturation of nucleoprotein" "mRNA processing" "2" "0" "1.001" "0.884" "0.890" "0.848" "0.867" "0.716" "0.767" "0.746" "0.766" "526.9" "527.3" "466.0" "469.0" "446.9" "457.0" "377.1" "404.2" "392.9" "403.3" "" "" "" "" "" "" "" "" "" "" "467.2" "436.8" "406.6" "350.7" "372.6" "419.8" "318.7" "334.1" "360.4" "403.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7700866187711353791" "False" "High" "IsMasterProtein" "Q9P0R6" "GSK3B-interacting protein OS=Homo sapiens OX=9606 GN=GSKIP PE=1 SV=2" "0.000" "False" "17.448" "15" "2" "5" "2" "139" "15.6" "4.48" "21.95" "2" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05303" "51527" "ENSG00000100744" "GSKIP" "B3KSZ0; hsa:51527; Q9BST1; Q9NWK0; Q9P0R6" "" "" "0" "0" "1.001" "0.994" "0.974" "0.984" "0.951" "0.959" "0.981" "1.061" "0.568" "830.5" "831.5" "825.2" "808.6" "817.5" "789.9" "796.1" "815.0" "881.0" "471.7" "" "" "" "" "" "" "" "" "" "" "736.5" "688.8" "720.0" "604.7" "681.7" "725.6" "672.9" "673.6" "808.0" "471.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3954168667574221268" "False" "High" "IsMasterProtein" "Q9H1J1" "Regulator of nonsense transcripts 3A OS=Homo sapiens OX=9606 GN=UPF3A PE=1 SV=1" "0.000" "False" "17.442" "6" "3" "5" "3" "476" "54.7" "9.03" "12.69" "3" "transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65110" "ENSG00000169062" "UPF3A" "A2A366; hsa:65110; Q5T8C3; Q5T8C9; Q7Z6N3; Q86YK1; Q9BZI8; Q9H1J1" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "2" "0" "0.486" "0.500" "0.496" "0.507" "0.491" "0.470" "0.513" "0.559" "0.353" "760.4" "369.4" "380.5" "377.5" "385.7" "373.2" "357.4" "390.0" "425.1" "268.2" "" "" "" "" "" "" "" "" "" "" "674.3" "306.0" "332.0" "282.3" "321.6" "342.8" "302.0" "322.3" "389.8" "268.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6705073720058711891" "False" "High" "IsMasterProtein" "Q96BP2" "Small ribosomal subunit protein mS37 OS=Homo sapiens OX=9606 GN=CHCHD1 PE=1 SV=1" "0.000" "False" "17.427" "23" "2" "2" "2" "118" "13.5" "10.21" "8.97" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "" "Pf06747" "118487" "ENSG00000172586" "CHCHD1" "hsa:118487; Q96BP2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.855" "0.724" "1.089" "0.914" "0.932" "1.036" "0.787" "0.773" "0.753" "83.8" "71.6" "60.7" "91.3" "76.6" "78.1" "86.8" "65.9" "64.7" "63.1" "" "" "" "" "" "" "" "" "" "" "74.3" "59.3" "52.9" "68.2" "63.9" "71.7" "73.3" "54.5" "59.4" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2419362748715144783" "False" "High" "IsMasterProtein" "Q0VG06" "Fanconi anemia core complex-associated protein 100 OS=Homo sapiens OX=9606 GN=FAAP100 PE=1 SV=3" "0.000" "False" "17.401" "4" "3" "3" "3" "881" "93.4" "5.29" "13.30" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15146" "80233" "ENSG00000185504" "FAAP100" "A6NNM1; hsa:80233; Q0VG06; Q8N3F7; Q9BV13; Q9H6K7; Q9H7E8" "Fanconi Anemia Pathway; PKR-mediated signaling" "DNA repair pathways, full network" "3" "0" "1.068" "1.059" "1.142" "1.048" "1.167" "1.129" "1.165" "1.012" "0.726" "243.0" "259.5" "257.4" "277.6" "254.6" "283.6" "274.2" "283.0" "245.9" "176.5" "" "" "" "" "" "" "" "" "" "" "215.5" "215.0" "224.6" "207.6" "212.3" "260.6" "231.8" "233.9" "225.5" "176.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2636434062481616227" "False" "High" "IsMasterProtein" "P42858" "Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2" "0.000" "False" "17.361" "2" "5" "5" "5" "3142" "347.4" "6.20" "14.17" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf20925, Pf20926, Pf20927" "3064" "ENSG00000197386" "HTT" "hsa:3064; P42858; Q9UQB7" "Regulation of MECP2 expression and activity" "Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome; 15q25 copy number variation; HDAC6 interactions in the central nervous system" "7" "0" "1.046" "0.953" "1.094" "1.084" "0.917" "1.119" "1.090" "0.855" "1.451" "267.5" "279.8" "255.0" "292.6" "290.1" "245.4" "299.4" "291.7" "228.8" "388.1" "" "" "" "" "" "" "" "" "" "" "237.2" "231.7" "222.5" "218.8" "241.9" "225.4" "253.0" "241.1" "209.9" "388.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4134532342981628088" "False" "High" "IsMasterProtein" "Q9BSV6" "tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens OX=9606 GN=TSEN34 PE=1 SV=1" "0.000" "False" "17.347" "13" "3" "3" "3" "310" "33.6" "8.43" "15.67" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01974" "79042" "ENSG00000170892; ENSG00000273896; ENSG00000274078; ENSG00000274129; ENSG00000274672; ENSG00000274796; ENSG00000275165; ENSG00000278605; ENSG00000278622; ENSG00000278712" "TSEN34" "A6NNB1; B0V3J1; hsa:79042; Q9BSV6; Q9BVT1; Q9H6H5" "tRNA processing in the nucleus" "" "1" "0" "0.904" "0.905" "0.814" "0.839" "0.888" "0.744" "0.764" "0.961" "2.492" "452.5" "409.0" "409.4" "368.3" "379.6" "401.6" "336.5" "345.7" "434.7" "1127.5" "" "" "" "" "" "" "" "" "" "" "401.3" "338.8" "357.2" "275.4" "316.6" "369.0" "284.4" "285.8" "398.7" "1127.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8286530119888385384" "False" "High" "IsMasterProtein" "P36969" "Phospholipid hydroperoxide glutathione peroxidase GPX4 OS=Homo sapiens OX=9606 GN=GPX4 PE=1 SV=3" "0.000" "False" "17.326" "22" "4" "4" "4" "197" "22.2" "8.37" "10.34" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00255" "2879" "ENSG00000167468" "GPX4" "hsa:2879; O43381; P36969; Q6PJ59; Q9UPK2" "Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "11" "0" "1.060" "0.849" "1.182" "1.112" "1.098" "1.032" "0.994" "1.002" "0.415" "148.9" "157.9" "126.4" "176.0" "165.6" "163.5" "153.7" "148.0" "149.2" "61.8" "" "" "" "" "" "" "" "" "" "" "132.1" "130.8" "110.3" "131.6" "138.1" "150.2" "129.9" "122.4" "136.8" "61.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "High" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.000" "False" "17.306" "4" "3" "5" "3" "961" "104.3" "5.27" "17.92" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "" "14" "0" "1.257" "0.954" "1.156" "0.963" "0.954" "0.884" "1.137" "1.142" "1.045" "69.9" "87.8" "66.6" "80.7" "67.3" "66.6" "61.8" "79.4" "79.8" "73.0" "" "" "" "" "" "" "" "" "" "" "61.9" "72.7" "58.1" "60.4" "56.1" "61.2" "52.2" "65.6" "73.1" "73.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446725702153589765" "False" "High" "IsMasterProtein" "Q9Y2T2" "AP-3 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP3M1 PE=1 SV=1" "0.000" "False" "17.306" "15" "6" "7" "6" "418" "46.9" "6.93" "20.56" "6" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "26985" "ENSG00000185009" "AP3M1" "hsa:26985; Q5JQ12; Q9H5L2; Q9Y2T2" "Association of TriC/CCT with target proteins during biosynthesis" "" "1" "0" "1.024" "1.027" "0.962" "0.977" "0.987" "1.232" "0.893" "1.040" "3.073" "351.7" "360.2" "361.3" "338.4" "343.7" "347.1" "433.3" "314.2" "365.7" "1080.9" "" "" "" "" "" "" "" "" "" "" "311.9" "298.4" "315.2" "253.1" "286.6" "318.8" "366.2" "259.7" "335.4" "1080.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "17.298" "10" "5" "5" "5" "436" "47.7" "5.85" "15.39" "5" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "0.994" "0.877" "0.943" "0.952" "0.797" "1.077" "0.911" "0.844" "2.072" "192.8" "191.6" "169.1" "181.9" "183.5" "153.6" "207.6" "175.7" "162.6" "399.4" "" "" "" "" "" "" "" "" "" "" "171.0" "158.7" "147.5" "136.0" "153.1" "141.1" "175.5" "145.2" "149.2" "399.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-212858070142576811" "False" "High" "IsMasterProtein" "Q86VX2" "COMM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=COMMD7 PE=1 SV=2" "0.000" "False" "17.286" "18" "3" "4" "3" "200" "22.5" "5.92" "17.58" "3" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf07258, Pf21672" "149951" "ENSG00000149600" "COMMD7" "A2BHJ2; B3KTZ2; hsa:149951; Q5JYB0; Q86VX2; Q96SI7; Q9BW53" "Neddylation" "" "1" "0" "1.032" "1.089" "1.115" "1.059" "1.084" "1.116" "1.091" "0.933" "0.862" "488.2" "503.6" "531.5" "544.5" "516.9" "529.3" "544.7" "532.6" "455.7" "420.6" "" "" "" "" "" "" "" "" "" "" "432.9" "417.2" "463.8" "407.2" "431.0" "486.2" "460.4" "440.2" "417.9" "420.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.000" "False" "17.254" "5" "4" "4" "4" "847" "94.1" "6.23" "12.67" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "13" "0" "1.109" "0.922" "0.988" "0.909" "0.999" "0.924" "0.602" "0.773" "4.604" "254.7" "282.4" "235.0" "251.8" "231.6" "254.6" "235.4" "153.4" "197.0" "1172.9" "" "" "" "" "" "" "" "" "" "" "225.9" "233.9" "205.0" "188.3" "193.1" "233.8" "199.0" "126.8" "180.7" "1172.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.000" "False" "17.221" "13" "2" "3" "2" "243" "26.5" "4.78" "14.12" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "Role of LAT2/NTAL/LAB on calcium mobilization" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "3" "0" "0.986" "0.996" "1.054" "1.083" "1.070" "0.929" "1.052" "0.977" "0.689" "312.4" "308.1" "311.1" "329.2" "338.4" "334.4" "290.3" "328.6" "305.1" "215.2" "" "" "" "" "" "" "" "" "" "" "277.0" "255.2" "271.5" "246.2" "282.2" "307.2" "245.3" "271.6" "279.9" "215.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7401329575601911727" "False" "High" "IsMasterProtein" "P13674" "Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2" "0.000" "False" "17.208" "8" "5" "5" "5" "534" "61.0" "6.01" "15.94" "5" "cell organization and biogenesis" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf08336, Pf13640" "5033" "ENSG00000122884" "P4HA1" "C9JL12; hsa:5033; P13674; Q15082; Q15083; Q5VSQ5" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "1.029" "0.905" "0.947" "0.940" "1.106" "1.084" "0.960" "1.114" "1.818" "159.6" "164.3" "144.4" "151.1" "150.1" "176.6" "173.1" "153.2" "177.7" "290.2" "" "" "" "" "" "" "" "" "" "" "141.6" "136.1" "126.0" "113.0" "125.1" "162.2" "146.3" "126.6" "163.0" "290.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740935786864817136" "False" "High" "IsMasterProtein" "Q9BRX2" "Protein pelota homolog OS=Homo sapiens OX=9606 GN=PELO PE=1 SV=2" "0.000" "False" "17.152" "6" "2" "2" "2" "385" "43.3" "6.34" "8.29" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "Pf03463, Pf03464, Pf03465" "53918" "ENSG00000152684" "PELO" "hsa:53918; Q9BRX2; Q9GZS6; Q9Y306" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "1" "0" "0.704" "0.863" "1.013" "1.022" "0.860" "1.096" "0.010" "0.940" "30.849" "17.7" "12.4" "15.3" "17.9" "18.1" "15.2" "19.4" "0.0" "16.6" "545.0" "" "" "" "" "" "" "" "" "" "" "15.7" "10.3" "13.3" "13.4" "15.1" "14.0" "16.4" "0.0" "15.2" "545.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2806721064947217400" "False" "High" "IsMasterProtein" "P0C024" "Peroxisomal coenzyme A diphosphatase NUDT7 OS=Homo sapiens OX=9606 GN=NUDT7 PE=1 SV=1" "0.000" "False" "17.151" "13" "3" "5" "3" "238" "26.9" "7.05" "17.56" "3" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00293" "283927" "ENSG00000140876" "NUDT7" "B4DLE5; H3BUB8; hsa:283927; P0C024" "Peroxisomal lipid metabolism; Peroxisomal protein import" "" "2" "0" "1.131" "1.049" "0.768" "1.112" "1.113" "0.931" "1.023" "1.112" "1.129" "136.6" "154.5" "143.3" "104.9" "151.9" "152.1" "127.2" "139.7" "151.9" "154.3" "" "" "" "" "" "" "" "" "" "" "121.1" "128.0" "125.1" "78.4" "126.7" "139.7" "107.5" "115.5" "139.3" "154.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5633919100605792812" "False" "High" "IsMasterProtein" "O43482" "Protein Mis18-beta OS=Homo sapiens OX=9606 GN=OIP5 PE=1 SV=2" "0.000" "False" "17.147" "21" "5" "5" "5" "229" "24.7" "7.37" "14.41" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03226" "11339" "ENSG00000104147" "OIP5" "hsa:11339; O43482; Q96BX7" "Deposition of new CENPA-containing nucleosomes at the centromere" "" "1" "0" "1.115" "1.038" "1.080" "1.130" "1.036" "1.158" "1.106" "1.117" "0.697" "146.8" "163.6" "152.3" "158.6" "165.9" "152.1" "169.9" "162.3" "163.9" "102.3" "" "" "" "" "" "" "" "" "" "" "130.2" "135.6" "132.9" "118.6" "138.3" "139.7" "143.6" "134.2" "150.3" "102.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "High" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.000" "False" "17.136" "25" "2" "2" "2" "127" "14.6" "4.70" "10.09" "2" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "1.035" "0.987" "0.911" "0.985" "0.896" "0.943" "0.806" "0.845" "1.739" "162.1" "167.7" "159.9" "147.7" "159.7" "145.3" "152.9" "130.6" "137.0" "281.9" "" "" "" "" "" "" "" "" "" "" "143.7" "138.9" "139.5" "110.5" "133.2" "133.5" "129.3" "107.9" "125.6" "281.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "High" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.000" "False" "17.135" "7" "5" "5" "5" "588" "68.0" "7.33" "16.32" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.983" "0.905" "1.006" "1.043" "1.076" "0.796" "0.170" "0.850" "11.870" "207.0" "203.5" "187.3" "208.2" "215.8" "222.7" "164.8" "35.2" "176.0" "2457.2" "" "" "" "" "" "" "" "" "" "" "183.6" "168.5" "163.5" "155.7" "180.0" "204.6" "139.3" "29.1" "161.4" "2457.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "17.103" "7" "3" "3" "3" "494" "55.0" "7.12" "11.82" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "Formation of the active cofactor, UDP-glucuronate" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "3" "0" "1.033" "0.904" "1.010" "1.037" "0.937" "1.104" "1.004" "0.938" "0.686" "191.6" "197.8" "173.2" "193.5" "198.6" "179.5" "211.5" "192.3" "179.8" "131.5" "" "" "" "" "" "" "" "" "" "" "169.9" "163.9" "151.1" "144.7" "165.6" "164.9" "178.8" "159.0" "164.9" "131.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "17.101" "4" "3" "3" "3" "785" "88.2" "9.28" "11.71" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "IRF3-mediated induction of type I IFN" "" "2" "0" "1.072" "1.097" "1.142" "1.200" "0.999" "1.127" "0.572" "1.163" "10.728" "153.4" "164.4" "168.2" "175.2" "184.1" "153.3" "172.8" "87.7" "178.4" "1645.5" "" "" "" "" "" "" "" "" "" "" "136.0" "136.2" "146.8" "131.0" "153.5" "140.8" "146.1" "72.5" "163.7" "1645.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "17.067" "12" "5" "5" "5" "373" "40.4" "8.76" "17.02" "5" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "3" "0" "0.948" "0.970" "0.900" "0.904" "1.046" "0.857" "0.895" "0.832" "0.346" "200.2" "189.9" "194.3" "180.2" "181.0" "209.5" "171.6" "179.3" "166.7" "69.4" "" "" "" "" "" "" "" "" "" "" "177.6" "157.3" "169.5" "134.8" "151.0" "192.5" "145.1" "148.2" "152.8" "69.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8165689774405731487" "False" "High" "IsMasterProtein" "Q9NS18" "Glutaredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX2 PE=1 SV=1" "0.000" "False" "17.056" "19" "3" "5" "3" "164" "18.0" "9.11" "17.65" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462" "51022" "ENSG00000023572" "GLRX2" "hsa:51022; Q3LR69; Q7L1N7; Q96JC0; Q9NS18; Q9Y3D4" "" "" "0" "0" "0.896" "1.135" "0.595" "1.070" "1.174" "0.916" "1.123" "1.219" "0.576" "357.1" "319.9" "405.4" "212.4" "382.1" "419.2" "327.0" "400.9" "435.3" "205.6" "" "" "" "" "" "" "" "" "" "" "316.6" "265.0" "353.8" "158.8" "318.6" "385.1" "276.4" "331.4" "399.3" "205.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5444771599092088743" "False" "High" "IsMasterProtein" "Q96EY9" "Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Homo sapiens OX=9606 GN=ADAT3 PE=1 SV=1" "0.000" "False" "17.049" "13" "5" "5" "5" "351" "38.0" "7.88" "16.20" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00383" "113179" "" "ADAT3" "hsa:113179; Q96EY9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.002" "0.954" "1.129" "1.043" "1.001" "1.087" "0.987" "0.889" "0.939" "222.4" "223.0" "212.1" "251.2" "232.0" "222.6" "241.9" "219.6" "197.8" "208.9" "" "" "" "" "" "" "" "" "" "" "197.3" "184.7" "185.1" "187.8" "193.5" "204.5" "204.4" "181.5" "181.4" "208.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "877541021914049463" "False" "High" "IsMasterProtein" "Q53S08" "Ras-related protein Rab-6D OS=Homo sapiens OX=9606 GN=RAB6D PE=1 SV=1" "0.000" "False" "17.047" "12" "2" "2" "1" "254" "28.2" "6.74" "10.26" "2" "transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "150786" "ENSG00000233087" "RAB6D" "hsa:150786; Q53S08" "" "" "0" "0" "1.085" "1.072" "0.964" "1.157" "1.210" "1.031" "1.085" "0.932" "0.584" "130.5" "141.7" "139.9" "125.9" "151.0" "157.9" "134.6" "141.6" "121.7" "76.2" "" "" "" "" "" "" "" "" "" "" "115.7" "117.4" "122.1" "94.1" "125.9" "145.1" "113.8" "117.0" "111.6" "76.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5995744781224398015" "False" "High" "IsMasterProtein" "P10746" "Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1" "0.000" "False" "17.020" "20" "3" "4" "3" "265" "28.6" "5.48" "14.57" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf02602" "7390" "ENSG00000188690" "UROS" "B2RC13; D3DRF7; hsa:7390; P10746; Q9H2T1" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "1.229" "0.912" "1.030" "1.044" "0.982" "1.054" "1.185" "0.801" "0.911" "47.3" "58.1" "43.1" "48.7" "49.4" "46.4" "49.8" "56.0" "37.9" "43.1" "" "" "" "" "" "" "" "" "" "" "41.9" "48.1" "37.6" "36.4" "41.2" "42.7" "42.1" "46.3" "34.7" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459383988131840815" "False" "High" "IsMasterProtein" "Q9ULP0" "Protein NDRG4 OS=Homo sapiens OX=9606 GN=NDRG4 PE=1 SV=2" "0.000" "False" "16.965" "11" "3" "4" "3" "352" "38.4" "6.21" "12.36" "3" "cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "" "Pf03096" "65009" "ENSG00000103034" "NDRG4" "B3KNU2; B4DK66; B4DSW5; H7C600; hsa:65009; Q6ZNE7; Q6ZTI7; Q96PL9; Q9GZM1; Q9GZN3; Q9GZX0; Q9ULP0" "" "" "0" "0" "1.111" "1.060" "0.977" "0.960" "1.085" "0.977" "1.044" "1.042" "1.043" "437.0" "485.4" "463.1" "427.1" "419.7" "474.0" "426.8" "456.3" "455.4" "455.7" "" "" "" "" "" "" "" "" "" "" "387.5" "402.1" "404.0" "319.4" "350.0" "435.5" "360.7" "377.2" "417.7" "455.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5305151798806457032" "False" "High" "IsMasterProtein" "Q9UJ68" "Mitochondrial peptide methionine sulfoxide reductase OS=Homo sapiens OX=9606 GN=MSRA PE=1 SV=1" "0.000" "False" "16.943" "17" "4" "5" "4" "235" "26.1" "8.09" "17.47" "4" "protein metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01625" "4482" "ENSG00000175806; ENSG00000285250" "MSRA" "E9PAS8; hsa:4482; Q52TC4; Q549N4; Q66MI7; Q9UJ68" "Protein repair" "Sulindac metabolic pathway; Methionine de novo and salvage pathway; 8p23.1 copy number variation syndrome" "4" "0" "0.928" "0.909" "0.909" "0.943" "0.949" "0.907" "0.786" "1.028" "4.107" "294.7" "273.5" "267.9" "267.9" "277.8" "279.6" "267.2" "231.5" "302.8" "1210.3" "" "" "" "" "" "" "" "" "" "" "261.3" "226.5" "233.7" "200.4" "231.6" "256.8" "225.9" "191.4" "277.7" "1210.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.000" "False" "16.923" "19" "7" "8" "5" "273" "33.2" "10.35" "28.85" "7" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "1.106" "0.810" "0.853" "0.834" "0.923" "1.008" "0.977" "1.086" "0.765" "566.6" "626.6" "459.1" "483.2" "472.3" "523.0" "571.2" "553.7" "615.4" "433.3" "" "" "" "" "" "" "" "" "" "" "502.4" "519.0" "400.6" "361.4" "393.8" "480.5" "482.8" "457.7" "564.4" "433.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3318503761924520630" "False" "High" "IsMasterProtein" "Q96R06" "Sperm-associated antigen 5 OS=Homo sapiens OX=9606 GN=SPAG5 PE=1 SV=2" "0.000" "False" "16.922" "4" "4" "5" "4" "1193" "134.3" "5.00" "13.21" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "10615" "ENSG00000076382" "SPAG5" "hsa:10615; O95213; Q96R06; Q9BWE8; Q9NT17; Q9UFE6" "" "" "0" "0" "0.883" "0.819" "0.946" "0.868" "0.820" "0.809" "0.251" "0.850" "12.474" "178.5" "157.7" "146.1" "168.9" "154.8" "146.4" "144.3" "44.8" "151.7" "2226.1" "" "" "" "" "" "" "" "" "" "" "158.3" "130.6" "127.5" "126.3" "129.1" "134.5" "122.0" "37.0" "139.2" "2226.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8767729618822811067" "False" "High" "IsMasterProtein" "O14933" "Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4" "0.000" "False" "16.916" "20" "3" "4" "3" "153" "17.8" "7.88" "14.34" "3" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "9246" "ENSG00000156587" "UBE2L6" "A6NDM6; A8MY53; hsa:9246; O14933; Q8N5D8; Q9UEZ0" "Antigen processing: Ubiquitination & Proteasome degradation; RSV-host interactions; Amyloid fiber formation; PKR-mediated signaling; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome" "11" "0" "0.991" "1.011" "1.000" "1.008" "0.997" "1.043" "0.958" "0.980" "2.909" "410.4" "406.7" "414.8" "410.5" "413.7" "409.2" "428.1" "393.1" "402.1" "1193.6" "" "" "" "" "" "" "" "" "" "" "363.9" "336.9" "362.0" "307.0" "345.0" "375.9" "361.8" "324.9" "368.8" "1193.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3969710029576412220" "False" "High" "IsMasterProtein" "Q9Y3T6" "R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3" "0.000" "False" "16.912" "11" "4" "6" "4" "440" "49.1" "5.63" "21.85" "4" "" "" "nucleic acid binding activity" "Pf01424" "203069" "ENSG00000104679" "R3HCC1" "B7ZLI1; hsa:203069; Q9Y3T6" "" "" "0" "0" "1.045" "1.068" "1.047" "0.905" "0.901" "1.039" "0.889" "0.864" "1.218" "241.0" "251.9" "257.3" "252.4" "218.2" "217.1" "250.4" "214.1" "208.3" "293.6" "" "" "" "" "" "" "" "" "" "" "213.7" "208.7" "224.5" "188.7" "181.9" "199.5" "211.6" "177.0" "191.0" "293.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894202004243013211" "False" "High" "IsMasterProtein" "O15530" "3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1" "0.000" "False" "16.911" "6" "3" "3" "3" "556" "63.1" "7.36" "12.16" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf14593" "5170" "ENSG00000140992" "PDPK1" "H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5" "Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway" "46" "0" "0.960" "0.902" "1.102" "1.019" "1.056" "1.210" "0.958" "1.125" "2.675" "191.8" "184.2" "173.0" "211.4" "195.4" "202.6" "232.1" "183.7" "215.7" "513.1" "" "" "" "" "" "" "" "" "" "" "170.1" "152.6" "150.9" "158.1" "162.9" "186.1" "196.2" "151.8" "197.8" "513.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4850932002920581345" "False" "High" "IsMasterProtein" "Q96GX5" "Serine/threonine-protein kinase greatwall OS=Homo sapiens OX=9606 GN=MASTL PE=1 SV=1" "0.000" "False" "16.872" "4" "4" "6" "3" "879" "97.3" "5.99" "17.49" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "84930" "ENSG00000120539" "MASTL" "hsa:84930; Q5T8D5; Q5T8D7; Q8NCD6; Q96GX5; Q96SJ5" "MASTL Facilitates Mitotic Progression" "" "1" "0" "1.191" "1.294" "1.013" "0.787" "1.300" "1.414" "0.199" "1.734" "17.547" "10.4" "12.4" "13.5" "10.6" "8.2" "13.6" "14.7" "2.1" "18.1" "182.9" "" "" "" "" "" "" "" "" "" "" "9.2" "10.3" "11.8" "7.9" "6.8" "12.4" "12.5" "1.7" "16.6" "182.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.000" "False" "16.828" "19" "5" "5" "5" "257" "28.0" "11.03" "15.06" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Protein hydroxylation; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "1.114" "1.043" "0.894" "1.031" "1.040" "0.803" "0.980" "1.148" "0.728" "132.6" "147.6" "138.2" "118.5" "136.7" "137.9" "106.5" "129.9" "152.1" "96.5" "" "" "" "" "" "" "" "" "" "" "117.6" "122.3" "120.6" "88.6" "114.0" "126.7" "90.0" "107.4" "139.5" "96.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "16.827" "6" "3" "4" "2" "512" "57.9" "4.42" "14.29" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "1" "1.036" "0.978" "1.056" "0.944" "0.842" "1.016" "0.938" "0.941" "1.330" "276.0" "285.8" "269.9" "291.6" "260.6" "232.5" "280.4" "259.0" "259.7" "367.1" "" "" "" "" "" "" "" "" "" "" "244.8" "236.8" "235.5" "218.1" "217.3" "213.6" "237.0" "214.1" "238.2" "367.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888035968268434758" "False" "High" "IsMasterProtein" "Q9Y3B2" "Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1" "0.000" "False" "16.818" "26" "4" "4" "4" "195" "21.4" "8.24" "16.94" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf10447, Pf14382" "51013" "ENSG00000171311" "EXOSC1" "B2R9B3; hsa:51013; Q5JTH3; Q9Y3B2" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "0.929" "1.027" "1.099" "0.926" "1.024" "0.963" "0.930" "0.967" "2.892" "274.3" "254.8" "281.5" "301.3" "253.9" "281.0" "264.0" "255.2" "265.3" "793.1" "" "" "" "" "" "" "" "" "" "" "243.2" "211.1" "245.7" "225.4" "211.7" "258.1" "223.2" "210.9" "243.4" "793.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.000" "False" "16.818" "33" "3" "8" "2" "79" "9.9" "8.46" "27.71" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "" "Small cell lung cancer" "1" "0" "0.978" "0.955" "0.969" "1.046" "1.062" "0.802" "0.778" "0.902" "1.810" "342.4" "334.9" "326.8" "331.6" "358.0" "363.7" "274.8" "266.3" "308.8" "619.9" "" "" "" "" "" "" "" "" "" "" "303.6" "277.4" "285.2" "248.0" "298.5" "334.1" "232.2" "220.1" "283.2" "619.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933830844704503327" "False" "High" "IsMasterProtein" "Q8N680" "Zinc finger and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZBTB2 PE=1 SV=1" "0.000" "False" "16.807" "8" "3" "3" "3" "514" "57.3" "6.10" "12.52" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "57621" "ENSG00000181472" "ZBTB2" "A8K7C7; hsa:57621; Q5SZ81; Q8N680; Q9P245" "" "Ectoderm differentiation" "1" "0" "1.050" "0.998" "1.059" "1.089" "1.103" "1.005" "0.972" "0.998" "0.724" "516.5" "542.5" "515.7" "546.8" "562.7" "569.9" "519.1" "502.0" "515.4" "374.0" "" "" "" "" "" "" "" "" "" "" "458.1" "449.4" "450.0" "408.9" "469.2" "523.5" "438.7" "415.0" "472.7" "374.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6951101032549152638" "False" "High" "IsMasterProtein" "Q9BYD3" "Large ribosomal subunit protein uL4m OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" "0.000" "False" "16.790" "15" "4" "5" "4" "311" "34.9" "9.72" "17.25" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00573" "51073" "ENSG00000105364" "MRPL4" "A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.199" "1.153" "1.303" "1.083" "0.892" "1.153" "1.051" "1.100" "1.624" "127.7" "153.2" "147.2" "166.5" "138.4" "113.9" "147.3" "134.3" "140.5" "207.4" "" "" "" "" "" "" "" "" "" "" "113.3" "126.9" "128.5" "124.5" "115.4" "104.6" "124.5" "111.0" "128.8" "207.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2792434032950857374" "False" "High" "IsMasterProtein" "Q96HR3" "Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1" "0.000" "False" "16.762" "16" "3" "4" "3" "178" "20.3" "8.27" "12.61" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11315" "90390" "ENSG00000164758" "MED30" "C6GKU9; hsa:90390; Q96HR3" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.212" "1.275" "1.543" "1.432" "1.201" "1.270" "1.211" "0.898" "2.219" "68.2" "82.6" "86.9" "105.2" "97.6" "81.9" "86.6" "82.6" "61.3" "151.3" "" "" "" "" "" "" "" "" "" "" "60.5" "68.4" "75.9" "78.7" "81.4" "75.2" "73.2" "68.3" "56.2" "151.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516422207583123109" "False" "High" "IsMasterProtein" "Q9NUD5" "Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2" "0.000" "False" "16.762" "13" "6" "9" "6" "403" "43.5" "8.53" "23.72" "6" "stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "85364" "ENSG00000247315" "ZCCHC3" "hsa:85364; Q3B7J3; Q6NT79; Q9NUD5" "" "" "0" "0" "0.983" "0.931" "1.010" "1.019" "1.022" "0.996" "1.009" "1.063" "0.857" "412.7" "405.8" "384.2" "416.8" "420.5" "422.0" "411.0" "416.3" "438.8" "353.6" "" "" "" "" "" "" "" "" "" "" "366.0" "336.2" "335.2" "311.7" "350.7" "387.6" "347.3" "344.1" "402.4" "353.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8473772251373638669" "False" "High" "IsMasterProtein" "Q12907" "Vesicular integral-membrane protein VIP36 OS=Homo sapiens OX=9606 GN=LMAN2 PE=1 SV=1" "0.000" "False" "16.751" "12" "4" "4" "4" "356" "40.2" "6.95" "14.76" "4" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03388" "10960" "ENSG00000169223" "LMAN2" "hsa:10960; Q12907; Q53HH1" "COPII-mediated vesicle transport; Cargo concentration in the ER" "5q35 copy number variation" "3" "0" "1.050" "0.964" "1.061" "1.038" "0.969" "1.120" "0.940" "0.911" "0.887" "293.5" "308.1" "282.8" "311.4" "304.7" "284.4" "328.8" "276.0" "267.3" "260.2" "" "" "" "" "" "" "" "" "" "" "260.2" "255.2" "246.8" "232.9" "254.1" "261.2" "277.9" "228.1" "245.2" "260.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7535964181824527260" "False" "High" "IsMasterProtein" "Q9H0E3" "Histone deacetylase complex subunit SAP130 OS=Homo sapiens OX=9606 GN=SAP130 PE=1 SV=1" "0.000" "False" "16.721" "3" "3" "4" "3" "1048" "110.3" "9.83" "12.07" "3" "other biological processes" "nucleus" "" "Pf16014" "79595" "ENSG00000136715" "SAP130" "B7ZLM3; C9K0X9; hsa:79595; Q4ZFV4; Q53T46; Q8WVW4; Q9H0E3; Q9H9G8" "NoRC negatively regulates rRNA expression; HATs acetylate histones" "" "2" "0" "0.933" "0.767" "0.885" "0.832" "0.809" "0.760" "0.735" "0.787" "0.759" "133.7" "124.8" "102.6" "118.4" "111.3" "108.2" "101.7" "98.4" "105.2" "101.4" "" "" "" "" "" "" "" "" "" "" "118.6" "103.4" "89.5" "88.6" "92.8" "99.4" "85.9" "81.3" "96.5" "101.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7586099756274293155" "False" "High" "IsMasterProtein" "Q71UM5" "Ribosomal protein eS27-like OS=Homo sapiens OX=9606 GN=RPS27L PE=1 SV=3" "0.000" "False" "16.714" "38" "3" "5" "1" "84" "9.5" "9.45" "11.43" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01667" "51065" "ENSG00000185088" "RPS27L" "hsa:51065; Q71UM5; Q9BTJ1" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "" "18" "0" "0.954" "0.942" "0.899" "0.847" "0.890" "0.763" "0.741" "0.899" "1.358" "77.2" "73.6" "72.7" "69.3" "65.4" "68.7" "58.9" "57.2" "69.4" "104.8" "" "" "" "" "" "" "" "" "" "" "68.4" "61.0" "63.5" "51.9" "54.5" "63.1" "49.8" "47.3" "63.7" "104.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3805240560895531655" "False" "High" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "0.000" "False" "16.714" "7" "2" "3" "2" "418" "45.9" "6.46" "12.35" "2" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "0.994" "1.029" "0.966" "1.107" "1.004" "0.833" "0.788" "0.844" "1.336" "420.4" "417.8" "432.6" "406.1" "465.5" "421.8" "350.2" "331.4" "354.8" "561.8" "" "" "" "" "" "" "" "" "" "" "372.8" "346.1" "377.5" "303.7" "388.2" "387.5" "296.0" "273.9" "325.4" "561.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7091276917323746637" "False" "High" "IsMasterProtein" "Q9H008" "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase OS=Homo sapiens OX=9606 GN=LHPP PE=1 SV=2" "0.000" "False" "16.712" "14" "3" "4" "3" "270" "29.1" "6.15" "14.36" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf13242, Pf13344" "64077" "ENSG00000107902" "LHPP" "B3KP20; hsa:64077; Q2TBE9; Q5VUV9; Q5VUW0; Q9H008" "Pyrophosphate hydrolysis" "" "1" "0" "1.019" "1.021" "1.047" "0.995" "1.020" "0.988" "0.975" "0.991" "0.451" "347.7" "354.3" "354.9" "364.1" "346.0" "354.6" "343.6" "338.8" "344.7" "156.9" "" "" "" "" "" "" "" "" "" "" "308.3" "293.5" "309.7" "272.3" "288.5" "325.8" "290.4" "280.1" "316.1" "156.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-181287195693513573" "False" "High" "IsMasterProtein" "Q96EA4" "Protein Spindly OS=Homo sapiens OX=9606 GN=SPDL1 PE=1 SV=2" "0.000" "False" "16.698" "9" "4" "4" "4" "605" "70.1" "5.47" "14.36" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "54908" "ENSG00000040275" "SPDL1" "B4E393; C9JS47; hsa:54908; Q8TEC8; Q96EA4; Q9HD44; Q9NX97" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.081" "1.005" "0.960" "1.037" "1.025" "1.056" "0.822" "1.224" "5.998" "111.4" "120.4" "111.9" "107.0" "115.5" "114.2" "117.7" "91.5" "136.3" "668.1" "" "" "" "" "" "" "" "" "" "" "98.8" "99.7" "97.7" "80.0" "96.3" "104.9" "99.5" "75.7" "125.0" "668.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561031833154832659" "False" "High" "IsMasterProtein" "O15379" "Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2" "0.000" "False" "16.697" "8" "4" "6" "3" "428" "48.8" "5.16" "21.02" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "8841" "ENSG00000171720" "HDAC3" "D3DQE1; hsa:8841; O15379; O43268; Q9UEI5; Q9UEV0" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "31" "0" "1.094" "1.068" "1.155" "1.204" "1.043" "0.961" "1.005" "0.858" "1.207" "568.1" "621.6" "606.6" "656.4" "684.3" "592.7" "546.0" "571.0" "487.6" "685.6" "" "" "" "" "" "" "" "" "" "" "503.8" "514.9" "529.3" "490.9" "570.6" "544.4" "461.4" "472.0" "447.2" "685.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "16.672" "14" "7" "7" "7" "521" "56.4" "7.99" "20.63" "7" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2q37 copy number variation syndrome" "2" "0" "1.164" "0.915" "1.162" "0.970" "0.993" "1.000" "1.003" "0.914" "0.660" "800.1" "931.6" "732.4" "930.0" "775.8" "794.9" "800.0" "802.3" "731.3" "528.2" "" "" "" "" "" "" "" "" "" "" "709.5" "771.7" "639.1" "695.5" "646.9" "730.2" "676.2" "663.2" "670.7" "528.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9003669345530149661" "False" "High" "IsMasterProtein" "Q15738" "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=NSDHL PE=1 SV=2" "0.000" "False" "16.663" "11" "4" "4" "4" "373" "41.9" "8.06" "14.51" "4" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01073" "50814" "ENSG00000147383; ENSG00000292192" "NSDHL" "D3DWT6; hsa:50814; O00344; Q15738" "Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "7" "0" "1.081" "0.997" "1.149" "1.070" "0.973" "1.076" "1.080" "1.015" "0.783" "161.4" "174.5" "160.9" "185.4" "172.7" "156.9" "173.6" "174.2" "163.8" "126.4" "" "" "" "" "" "" "" "" "" "" "143.1" "144.5" "140.4" "138.6" "144.0" "144.2" "146.7" "144.0" "150.2" "126.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8438939394960091078" "False" "High" "IsMasterProtein" "O00116" "Alkyldihydroxyacetonephosphate synthase, peroxisomal OS=Homo sapiens OX=9606 GN=AGPS PE=1 SV=1" "0.000" "False" "16.661" "7" "3" "3" "3" "658" "72.9" "7.34" "10.77" "3" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01565, Pf02913" "8540" "ENSG00000018510" "AGPS" "A5D8U9; hsa:8540; O00116; Q2TU35" "Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins" "Triacylglyceride synthesis" "4" "0" "1.277" "1.262" "1.326" "1.283" "1.202" "1.307" "1.356" "1.320" "0.886" "109.4" "139.7" "138.1" "145.1" "140.4" "131.5" "143.0" "148.4" "144.4" "96.9" "" "" "" "" "" "" "" "" "" "" "97.0" "115.7" "120.5" "108.5" "117.1" "120.8" "120.9" "122.6" "132.4" "96.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8583026759934693939" "False" "High" "IsMasterProtein" "Q9P1Z2" "Calcium-binding and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CALCOCO1 PE=1 SV=2" "0.000" "False" "16.636" "8" "5" "5" "5" "691" "77.3" "4.82" "15.68" "5" "cell-cell signaling;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07888, Pf17751, Pf18112" "57658" "ENSG00000012822" "CALCOCO1" "B3KVA8; hsa:57658; Q6FI59; Q71RC3; Q86WF8; Q96JU3; Q9H090; Q9P1Z2" "" "" "0" "0" "1.086" "0.991" "1.108" "0.963" "1.021" "1.048" "0.887" "0.953" "2.680" "424.2" "460.9" "420.4" "470.0" "408.4" "433.2" "444.5" "376.3" "404.1" "1137.1" "" "" "" "" "" "" "" "" "" "" "376.2" "381.8" "366.8" "351.5" "340.5" "398.0" "375.7" "311.1" "370.6" "1137.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8364917298053465575" "False" "High" "IsMasterProtein" "Q9UQ88" "Cyclin-dependent kinase 11A OS=Homo sapiens OX=9606 GN=CDK11A PE=1 SV=4" "0.000" "False" "16.588" "6" "6" "7" "6" "783" "91.3" "5.36" "20.72" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "728642" "ENSG00000008128" "CDK11A" "hsa:728642; O95227; O95228; O96012; Q12821; Q12853; Q12854; Q2TAJ0; Q5QPR0; Q5QPR1; Q5QPR2; Q9UBC4; Q9UBI3; Q9UEI1; Q9UEI2; Q9UP53; Q9UP54; Q9UP55; Q9UP56; Q9UQ86; Q9UQ87; Q9UQ88; Q9UQ89" "Recruitment of mitotic centrosome proteins and complexes" "1p36 copy number variation syndrome" "2" "0" "1.051" "0.928" "1.107" "0.951" "0.928" "0.925" "0.791" "0.899" "2.747" "397.2" "417.3" "368.5" "439.5" "377.9" "368.7" "367.6" "314.0" "357.0" "1090.9" "" "" "" "" "" "" "" "" "" "" "352.2" "345.7" "321.5" "328.7" "315.1" "338.7" "310.6" "259.5" "327.4" "1090.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "High" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.000" "False" "16.565" "38" "3" "7" "1" "84" "9.5" "9.45" "18.26" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "25" "1" "0.919" "1.044" "0.945" "0.986" "0.937" "0.850" "0.856" "0.891" "1.842" "435.3" "400.1" "454.3" "411.2" "429.2" "408.0" "370.0" "372.6" "387.7" "801.9" "" "" "" "" "" "" "" "" "" "" "386.0" "331.4" "396.4" "307.6" "357.9" "374.8" "312.7" "308.0" "355.6" "801.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2919064090187144388" "False" "High" "IsMasterProtein" "Cont_P00760" "Serine protease 1 OS=Bos taurus OX=9913 GN=PRSS1 PE=1 SV=3" "0.000" "True" "16.558" "15" "3" "4" "2" "246" "25.8" "8.07" "16.18" "3" "protein metabolism;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00089" "615026; 780933" "ENSBIXG00000023431; ENSBIXG00005009443; ENSBTAG00000050323; ENSBTAG00000052726" "LOC113890875; PRSS1" "A0A4W2FD21; A6H6Y3; bta:615026; bta:780933; P00760" "" "" "0" "0" "0.730" "0.829" "20.346" "0.625" "0.470" "0.766" "0.996" "1.287" "1.042" "30.8" "22.5" "25.6" "627.7" "19.3" "14.5" "23.6" "30.7" "39.7" "32.1" "" "" "" "" "" "" "" "" "" "" "27.4" "18.6" "22.3" "469.4" "16.1" "13.3" "20.0" "25.4" "36.4" "32.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.000" "False" "16.547" "10" "4" "4" "4" "398" "44.4" "6.98" "16.57" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "0.873" "0.832" "0.810" "0.759" "0.637" "0.638" "0.516" "0.858" "5.524" "344.6" "300.8" "286.7" "279.0" "261.4" "219.6" "219.7" "177.9" "295.7" "1903.3" "" "" "" "" "" "" "" "" "" "" "305.6" "249.2" "250.2" "208.7" "218.0" "201.7" "185.7" "147.0" "271.2" "1903.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827998788629081219" "False" "High" "IsMasterProtein" "Q12834" "Cell division cycle protein 20 homolog OS=Homo sapiens OX=9606 GN=CDC20 PE=1 SV=2" "0.000" "False" "16.485" "5" "2" "5" "2" "499" "54.7" "9.23" "18.03" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf12894" "991" "ENSG00000117399" "CDC20" "B2R6Z6; D3DPJ1; hsa:991; Q12834; Q5JUY4; Q9BW56; Q9UQI9" "Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Ub-specific processing proteases; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; APC-Cdc20 mediated degradation of Nek2A; Phosphorylation of Emi1" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; HDAC6 interactions in the central nervous system" "23" "0" "0.923" "0.908" "0.837" "0.857" "0.902" "0.815" "0.698" "0.896" "2.626" "174.4" "160.9" "158.3" "145.9" "149.5" "157.3" "142.0" "121.7" "156.3" "458.0" "" "" "" "" "" "" "" "" "" "" "154.6" "133.3" "138.1" "109.1" "124.7" "144.5" "120.0" "100.6" "143.4" "458.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1398033593130895886" "False" "High" "IsMasterProtein" "O43264" "Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3" "0.000" "False" "16.476" "5" "4" "4" "4" "779" "88.8" "6.27" "15.24" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf06248, Pf20665, Pf20666" "9183" "ENSG00000086827" "ZW10" "A1A528; hsa:9183; O43264" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "0.995" "0.936" "0.997" "0.939" "0.899" "0.887" "0.715" "0.938" "4.034" "464.3" "461.8" "434.5" "462.8" "436.1" "417.2" "411.9" "331.9" "435.5" "1872.9" "" "" "" "" "" "" "" "" "" "" "411.7" "382.5" "379.1" "346.1" "363.7" "383.3" "348.1" "274.4" "399.4" "1872.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4044629129436372468" "False" "High" "IsMasterProtein" "Q14160" "Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=5" "0.000" "False" "16.447" "3" "6" "6" "6" "1630" "174.8" "5.07" "14.75" "6" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00560, Pf00595, Pf13855" "23513" "ENSG00000180900; ENSG00000274287" "SCRIB" "hsa:23513; Q14160; Q6P496; Q7Z5D1; Q8WWV8; Q96C69; Q96GG1" "CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; Asymmetric localization of PCP proteins; RND2 GTPase cycle; RND3 GTPase cycle" "Thyroid stimulating hormone (TSH) signaling pathway; Complement system in neuronal development and plasticity" "8" "0" "1.006" "0.812" "1.040" "0.909" "0.872" "0.938" "0.770" "0.925" "2.453" "721.6" "725.7" "586.2" "750.6" "656.1" "629.1" "676.9" "555.3" "667.8" "1770.4" "" "" "" "" "" "" "" "" "" "" "639.9" "601.1" "511.5" "561.3" "547.1" "577.9" "572.1" "459.0" "612.5" "1770.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709781459489319409" "False" "High" "IsMasterProtein" "Q9UHN1" "DNA polymerase subunit gamma-2 OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1" "0.000" "False" "16.437" "6" "3" "3" "3" "485" "54.9" "8.35" "11.26" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf03129" "11232" "ENSG00000256525" "POLG2" "hsa:11232; O00419; Q0IJ81; Q96GW2; Q9UHN1; Q9UK35; Q9UK94" "Transcriptional activation of mitochondrial biogenesis" "" "1" "0" "1.254" "1.199" "1.416" "1.375" "1.010" "1.224" "1.089" "1.303" "0.741" "127.9" "160.4" "153.3" "181.1" "175.8" "129.2" "156.5" "139.2" "166.6" "94.7" "" "" "" "" "" "" "" "" "" "" "113.4" "132.8" "133.8" "135.4" "146.6" "118.7" "132.3" "115.1" "152.8" "94.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2809025675902823137" "False" "High" "IsMasterProtein" "Q9H2Y7" "Zinc finger protein 106 OS=Homo sapiens OX=9606 GN=ZNF106 PE=1 SV=1" "0.000" "False" "16.405" "3" "6" "6" "5" "1883" "208.8" "7.15" "18.11" "6" "signal transduction" "other membranes;cytosol;nucleus" "other molecular function" "Pf00400" "64397" "ENSG00000103994" "ZNF106" "B4DZ40; E9PE29; hsa:64397; Q6NSD9; Q6PEK1; Q86T43; Q86T45; Q86T50; Q86T58; Q86TA9; Q96M37; Q9H2Y7; Q9H7B8" "" "" "0" "0" "0.900" "0.772" "0.939" "0.809" "0.744" "0.659" "0.712" "0.703" "1.383" "66.2" "59.5" "51.1" "62.1" "53.5" "49.3" "43.6" "47.1" "46.5" "91.5" "" "" "" "" "" "" "" "" "" "" "58.7" "49.3" "44.5" "46.4" "44.6" "45.2" "36.9" "39.0" "42.6" "91.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "16.404" "4" "3" "3" "3" "683" "77.5" "9.50" "13.26" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.016" "1.032" "1.006" "0.971" "1.010" "0.922" "0.681" "0.933" "4.999" "331.5" "336.9" "342.1" "333.4" "321.9" "334.9" "305.7" "225.7" "309.4" "1657.4" "" "" "" "" "" "" "" "" "" "" "294.0" "279.1" "298.5" "249.3" "268.4" "307.6" "258.3" "186.6" "283.8" "1657.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "16.392" "11" "4" "4" "4" "414" "47.6" "6.18" "14.78" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.740" "0.665" "0.663" "0.563" "0.530" "0.617" "0.455" "0.740" "2.762" "363.9" "269.2" "242.0" "241.1" "205.0" "192.7" "224.5" "165.6" "269.2" "1005.2" "" "" "" "" "" "" "" "" "" "" "322.7" "223.0" "211.2" "180.3" "170.9" "177.0" "189.8" "136.9" "246.9" "1005.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974219725755957834" "False" "High" "IsMasterProtein" "Q5HYJ3" "Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3" "0.000" "False" "16.390" "17" "6" "6" "5" "339" "38.7" "9.25" "22.04" "6" "" "nucleus" "" "Pf16046" "143684" "ENSG00000077458" "FAM76B" "B2R9C2; hsa:143684; Q5HYJ3; Q6PIU3; Q8TC53" "" "" "0" "1" "1.142" "1.016" "1.022" "0.999" "1.031" "1.040" "0.945" "1.092" "0.685" "331.5" "378.6" "336.8" "338.8" "331.0" "341.8" "344.6" "313.3" "361.9" "227.0" "" "" "" "" "" "" "" "" "" "" "294.0" "313.6" "293.9" "253.3" "276.0" "314.0" "291.3" "259.0" "331.9" "227.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845069297566421061" "False" "High" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "0.000" "False" "16.322" "5" "5" "5" "5" "906" "100.0" "6.29" "17.06" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "15" "0" "1.111" "1.050" "1.110" "1.001" "1.053" "0.988" "1.097" "0.965" "0.634" "230.8" "256.4" "242.3" "256.3" "231.1" "243.2" "228.1" "253.2" "222.9" "146.4" "" "" "" "" "" "" "" "" "" "" "204.7" "212.4" "211.4" "191.6" "192.7" "223.4" "192.7" "209.3" "204.4" "146.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6868774579306622081" "False" "High" "IsMasterProtein" "O43278" "Kunitz-type protease inhibitor 1 OS=Homo sapiens OX=9606 GN=SPINT1 PE=1 SV=2" "0.000" "False" "16.294" "7" "4" "7" "4" "529" "58.4" "6.29" "20.33" "4" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00014, Pf00057, Pf07502" "6692" "ENSG00000166145" "SPINT1" "hsa:6692; O43278; Q7Z7D2" "MET Receptor Activation; Signaling by MST1" "" "2" "0" "0.936" "0.966" "1.070" "1.039" "1.036" "1.009" "1.068" "1.071" "0.635" "228.8" "214.1" "220.9" "244.8" "237.8" "236.9" "231.0" "244.3" "245.0" "145.2" "" "" "" "" "" "" "" "" "" "" "202.9" "177.3" "192.8" "183.1" "198.3" "217.7" "195.2" "201.9" "224.7" "145.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8714366505281620526" "False" "High" "IsMasterProtein" "Q7L5Y9" "E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1" "0.000" "False" "16.256" "8" "3" "4" "3" "396" "45.3" "8.69" "18.08" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10607" "10296" "ENSG00000090316" "MAEA" "hsa:10296; O95285; Q5JB54; Q6ZRD6; Q7L5Y9; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84" "" "Ciliary landscape" "1" "0" "1.087" "0.945" "1.040" "1.011" "1.017" "1.012" "0.936" "1.047" "1.245" "471.4" "512.6" "445.6" "490.0" "476.6" "479.5" "477.2" "441.2" "493.4" "586.8" "" "" "" "" "" "" "" "" "" "" "418.0" "424.6" "388.8" "366.5" "397.4" "440.5" "403.3" "364.7" "452.5" "586.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1734934898581359440" "False" "High" "IsMasterProtein" "P61457" "Pterin-4-alpha-carbinolamine dehydratase OS=Homo sapiens OX=9606 GN=PCBD1 PE=1 SV=2" "0.000" "False" "16.234" "43" "5" "7" "4" "104" "12.0" "6.80" "23.69" "5" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01329" "5092" "ENSG00000166228" "PCBD1" "hsa:5092; P61457; P70519; P80095; Q9D930" "Phenylalanine metabolism" "" "1" "1" "1.003" "0.947" "1.097" "1.000" "1.097" "1.002" "1.017" "0.964" "0.621" "331.5" "332.4" "313.9" "363.6" "331.5" "363.6" "332.1" "337.2" "319.7" "205.7" "" "" "" "" "" "" "" "" "" "" "294.0" "275.4" "273.9" "272.0" "276.4" "334.0" "280.6" "278.7" "293.2" "205.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9115866675213369101" "False" "High" "IsMasterProtein" "Q99807" "5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ7 PE=1 SV=3" "0.000" "False" "16.232" "14" "3" "3" "3" "217" "24.3" "8.59" "11.66" "3" "other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf03232" "10229" "ENSG00000167186" "COQ7" "B2RDA9; hsa:10229; Q99807; Q9BTT7; Q9H0T5; Q9UEW5; Q9UNR5" "Ubiquinol biosynthesis" "" "1" "0" "1.203" "1.071" "1.212" "1.063" "0.995" "1.152" "1.056" "1.023" "0.698" "309.2" "371.8" "331.1" "374.9" "328.6" "307.6" "356.1" "326.6" "316.4" "215.8" "" "" "" "" "" "" "" "" "" "" "274.2" "308.0" "288.9" "280.4" "274.0" "282.5" "301.0" "270.0" "290.2" "215.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624164927491725104" "False" "High" "IsMasterProtein" "O75449" "Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1" "0.000" "False" "16.197" "9" "5" "5" "5" "491" "55.9" "6.90" "16.64" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "11104" "ENSG00000186625" "KATNA1" "E1P5A3; hsa:11104; O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52" "" "" "0" "0" "1.037" "0.914" "0.857" "1.072" "1.136" "1.078" "1.036" "1.126" "1.869" "295.7" "306.7" "270.3" "253.4" "317.1" "336.1" "318.8" "306.3" "333.0" "552.6" "" "" "" "" "" "" "" "" "" "" "262.3" "254.1" "235.9" "189.5" "264.4" "308.7" "269.4" "253.1" "305.4" "552.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7421726054682487966" "False" "High" "IsMasterProtein" "Q9NX18" "Succinate dehydrogenase assembly factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF2 PE=1 SV=1" "0.000" "False" "16.178" "28" "5" "5" "5" "166" "19.6" "6.80" "15.82" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf03937" "54949" "ENSG00000167985" "SDHAF2" "hsa:54949; Q9NX18" "" "Mitochondrial complex II assembly" "1" "0" "1.007" "1.042" "1.032" "0.967" "1.167" "1.107" "1.183" "1.146" "0.530" "507.6" "511.0" "529.1" "523.8" "491.0" "592.5" "562.1" "600.6" "581.7" "268.9" "" "" "" "" "" "" "" "" "" "" "450.1" "423.3" "461.6" "391.8" "409.4" "544.3" "475.0" "496.5" "533.5" "268.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "16.077" "14" "2" "4" "2" "168" "17.5" "5.49" "14.23" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "1.041" "1.045" "1.070" "1.000" "0.961" "0.982" "0.923" "1.009" "0.404" "416.6" "433.7" "435.6" "445.7" "416.5" "400.4" "409.0" "384.7" "420.3" "168.4" "" "" "" "" "" "" "" "" "" "" "369.5" "359.3" "380.1" "333.3" "347.3" "367.8" "345.7" "318.0" "385.5" "168.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530095289376032453" "False" "High" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.000" "False" "16.060" "19" "5" "5" "5" "243" "27.0" "9.16" "18.13" "5" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "1.043" "0.959" "1.127" "1.003" "0.975" "0.997" "0.926" "0.832" "0.553" "188.4" "196.5" "180.7" "212.3" "189.0" "183.8" "187.8" "174.4" "156.7" "104.1" "" "" "" "" "" "" "" "" "" "" "167.1" "162.8" "157.7" "158.7" "157.6" "168.8" "158.8" "144.1" "143.8" "104.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "16.000" "10" "4" "5" "4" "486" "55.7" "5.20" "17.18" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "Clathrin-mediated endocytosis" "" "1" "0" "1.024" "1.019" "0.986" "0.976" "1.030" "1.046" "0.905" "1.005" "3.796" "342.5" "350.8" "349.1" "337.7" "334.4" "352.6" "358.2" "310.1" "344.1" "1300.0" "" "" "" "" "" "" "" "" "" "" "303.7" "290.6" "304.6" "252.5" "278.8" "323.9" "302.7" "256.3" "315.6" "1300.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8897927759308668761" "False" "High" "IsMasterProtein" "Q3KQV9" "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2" "0.000" "False" "15.951" "6" "3" "4" "1" "507" "57.0" "6.32" "13.50" "3" "other metabolic processes" "" "other molecular function" "Pf01704" "91373" "ENSG00000197355" "UAP1L1" "A2AMJ8; hsa:91373; Q3KQV9; Q5SPZ2; Q69YQ3; Q6ZR38" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6208634135307330971" "False" "High" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "0.000" "False" "15.948" "6" "5" "5" "5" "764" "89.4" "5.81" "16.51" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "Ectoderm differentiation" "6" "0" "1.067" "1.002" "1.004" "1.008" "1.010" "1.017" "0.922" "0.957" "1.657" "459.4" "490.1" "460.5" "461.2" "463.0" "464.2" "467.3" "423.7" "439.5" "761.3" "" "" "" "" "" "" "" "" "" "" "407.4" "405.9" "401.8" "344.9" "386.0" "426.4" "395.0" "350.2" "403.1" "761.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4778122268276291111" "False" "High" "IsMasterProtein" "P49406" "Large ribosomal subunit protein bL19m OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "0.000" "False" "15.935" "12" "4" "4" "4" "292" "33.5" "9.50" "15.31" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Cytoplasmic ribosomal proteins" "4" "0" "0.947" "1.030" "0.928" "0.905" "0.888" "1.051" "1.103" "0.896" "2.379" "197.4" "187.0" "203.3" "183.1" "178.7" "175.3" "207.3" "217.6" "176.8" "469.5" "" "" "" "" "" "" "" "" "" "" "175.0" "154.9" "177.4" "136.9" "149.0" "161.0" "175.2" "179.9" "162.1" "469.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5271819707192533656" "False" "High" "IsMasterProtein" "Q9H7E9" "UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1" "0.000" "False" "15.897" "13" "3" "4" "3" "229" "25.0" "9.95" "13.40" "3" "" "" "" "Pf15393" "65265" "ENSG00000182307; ENSG00000291362" "C8orf33" "A6NGC0; hsa:65265; Q96BT8; Q9H7E9" "" "" "0" "0" "0.924" "0.939" "0.820" "0.861" "0.809" "0.794" "0.749" "0.760" "1.674" "283.7" "262.2" "266.4" "232.6" "244.4" "229.4" "225.2" "212.6" "215.6" "475.0" "" "" "" "" "" "" "" "" "" "" "251.6" "217.2" "232.5" "174.0" "203.8" "210.7" "190.3" "175.7" "197.7" "475.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-228772176721817864" "False" "High" "IsMasterProtein" "Q96HY6" "DDRGK domain-containing protein 1 OS=Homo sapiens OX=9606 GN=DDRGK1 PE=1 SV=2" "0.000" "False" "15.843" "14" "4" "7" "4" "314" "35.6" "5.12" "22.66" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09756" "65992" "ENSG00000198171" "DDRGK1" "A6NIU5; C9JSZ5; hsa:65992; Q96HY6; Q9BW47" "RHOA GTPase cycle" "" "1" "0" "1.163" "0.895" "0.970" "0.872" "0.895" "0.955" "0.841" "0.925" "0.955" "280.1" "325.8" "250.7" "271.7" "244.3" "250.6" "267.6" "235.5" "259.2" "267.4" "" "" "" "" "" "" "" "" "" "" "248.4" "269.9" "218.7" "203.2" "203.7" "230.2" "226.2" "194.6" "237.7" "267.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801357975470055423" "False" "High" "IsMasterProtein" "O14526" "F-BAR domain only protein 1 OS=Homo sapiens OX=9606 GN=FCHO1 PE=1 SV=2" "0.000" "False" "15.819" "3" "3" "3" "3" "889" "96.8" "6.96" "11.51" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00611, Pf10291" "23149" "ENSG00000130475" "FCHO1" "A6NHE6; A8K5U5; B4E120; hsa:23149; O14526; Q05C93; Q8IW22" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "1.038" "0.944" "1.016" "0.969" "0.876" "0.979" "0.808" "0.890" "2.760" "382.3" "396.9" "360.8" "388.3" "370.5" "334.7" "374.1" "308.8" "340.4" "1055.1" "" "" "" "" "" "" "" "" "" "" "339.0" "328.8" "314.8" "290.4" "309.0" "307.5" "316.2" "255.3" "312.2" "1055.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-352840310732152978" "False" "High" "IsMasterProtein" "Q8NFU3" "Thiosulfate:glutathione sulfurtransferase OS=Homo sapiens OX=9606 GN=TSTD1 PE=1 SV=3" "0.000" "False" "15.809" "39" "5" "6" "5" "115" "12.5" "6.07" "16.57" "5" "other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00581" "100131187" "ENSG00000215845" "TSTD1" "hsa:100131187; Q5SY48; Q5SY49; Q5SY50; Q5SY51; Q8NFU2; Q8NFU3; Q9BV22" "Sulfide oxidation to sulfate" "" "1" "0" "1.011" "1.031" "0.974" "0.968" "0.936" "0.968" "0.965" "0.990" "0.508" "760.3" "768.3" "783.5" "740.3" "735.7" "711.8" "735.7" "733.6" "752.4" "386.2" "" "" "" "" "" "" "" "" "" "" "674.2" "636.5" "683.6" "553.6" "613.4" "653.9" "621.8" "606.4" "690.1" "386.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1239693809215146352" "False" "High" "IsMasterProtein" "P37275" "Zinc finger E-box-binding homeobox 1 OS=Homo sapiens OX=9606 GN=ZEB1 PE=1 SV=2" "0.000" "False" "15.800" "3" "4" "5" "4" "1124" "124.0" "4.94" "18.08" "4" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf05605" "6935" "ENSG00000148516" "ZEB1" "B4DJV0; B4DUW9; E9PCM7; F5H4I8; hsa:6935; P37275; Q12924; Q13800; Q2KJ05; Q5T968; Q5VZ84; Q8NB68" "Interleukin-4 and Interleukin-13 signaling" "Hypoxia-mediated EMT and stemness; TGF-beta signaling pathway; Clear cell renal cell carcinoma pathways; Epithelial to mesenchymal transition in colorectal cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; CCL18 signaling pathway; Hypertrophy model" "8" "0" "1.020" "1.048" "0.905" "1.022" "1.092" "0.954" "0.900" "0.938" "0.716" "305.0" "311.2" "319.7" "276.1" "311.8" "333.2" "290.9" "274.4" "286.2" "218.3" "" "" "" "" "" "" "" "" "" "" "270.5" "257.7" "278.9" "206.5" "260.0" "306.1" "245.8" "226.8" "262.5" "218.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652692427915398655" "False" "High" "IsMasterProtein" "Q9H0H5" "Rac GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RACGAP1 PE=1 SV=1" "0.000" "False" "15.782" "9" "5" "5" "5" "632" "71.0" "8.88" "15.62" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00130, Pf00620" "29127" "ENSG00000161800" "RACGAP1" "hsa:29127; Q6PJ26; Q9H0H5; Q9NWN2; Q9P250; Q9P2W2" "RHOC GTPase cycle; RHOA GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; RHOB GTPase cycle" "S1P receptor signal transduction; Wnt signaling pathway and pluripotency" "13" "0" "0.967" "1.040" "1.028" "0.903" "0.965" "0.922" "0.820" "0.942" "2.435" "178.6" "172.8" "185.7" "183.5" "161.2" "172.4" "164.7" "146.5" "168.2" "434.9" "" "" "" "" "" "" "" "" "" "" "158.4" "143.1" "162.0" "137.3" "134.4" "158.4" "139.2" "121.1" "154.2" "434.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4078172975795956139" "False" "High" "IsMasterProtein" "Q7Z6V5" "tRNA-specific adenosine deaminase 2 OS=Homo sapiens OX=9606 GN=ADAT2 PE=1 SV=1" "0.000" "False" "15.763" "20" "4" "4" "4" "191" "21.0" "6.74" "15.99" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf14437" "134637" "ENSG00000189007" "ADAT2" "A6NL12; B3KWY3; hsa:134637; Q7Z327; Q7Z6V5; Q8IY39" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.943" "0.884" "0.867" "0.848" "0.940" "0.883" "0.852" "0.874" "0.618" "433.3" "408.8" "382.9" "375.8" "367.6" "407.2" "382.5" "369.3" "378.9" "267.9" "" "" "" "" "" "" "" "" "" "" "384.3" "338.6" "334.1" "281.1" "306.5" "374.0" "323.2" "305.3" "347.5" "267.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4612354553252099721" "False" "High" "IsMasterProtein" "Q12981" "Vesicle transport protein SEC20 OS=Homo sapiens OX=9606 GN=BNIP1 PE=1 SV=3" "0.000" "False" "15.758" "12" "3" "3" "3" "228" "26.1" "8.95" "11.98" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf03908" "662" "ENSG00000113734" "BNIP1" "D3DQM3; D3DQM4; D3DQM5; D3DQM6; hsa:662; O75622; O75623; O75624; Q12981; Q6K044; Q96FG4" "COPI-dependent Golgi-to-ER retrograde traffic" "" "1" "0" "1.270" "1.206" "1.189" "1.106" "1.008" "1.232" "1.066" "1.120" "0.418" "99.9" "126.9" "120.5" "118.9" "110.5" "100.7" "123.2" "106.6" "111.9" "41.8" "" "" "" "" "" "" "" "" "" "" "88.6" "105.1" "105.1" "88.9" "92.2" "92.5" "104.1" "88.1" "102.7" "41.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7985947186271226833" "False" "High" "IsMasterProtein" "Q9UPW0" "Forkhead box protein J3 OS=Homo sapiens OX=9606 GN=FOXJ3 PE=1 SV=2" "0.000" "False" "15.749" "7" "3" "4" "3" "622" "68.9" "7.09" "9.85" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250" "22887" "ENSG00000198815" "FOXJ3" "A7MBL7; A7MD18; D3DPW2; hsa:22887; Q9NSS7; Q9UPW0" "" "" "0" "0" "0.947" "0.881" "0.945" "0.965" "0.805" "0.850" "0.780" "0.795" "1.492" "118.3" "112.1" "104.3" "111.8" "114.2" "95.3" "100.6" "92.3" "94.1" "176.5" "" "" "" "" "" "" "" "" "" "" "104.9" "92.8" "91.0" "83.6" "95.2" "87.5" "85.0" "76.3" "86.3" "176.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7159036767897580858" "False" "High" "IsMasterProtein" "P20036" "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" "0.000" "False" "15.738" "16" "3" "3" "3" "260" "29.4" "5.21" "11.47" "3" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00993, Pf07654" "3113" "ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177" "HLA-DPA1" "A9YWH7; B9UKH4; O19722; O46883; P01905; P20036; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; Q9BCQ1; Q9TPX3; Q9XS10" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "1.193" "1.087" "0.969" "1.160" "1.195" "1.038" "1.096" "1.072" "0.697" "193.4" "230.7" "210.3" "187.4" "224.3" "231.1" "200.8" "212.0" "207.3" "134.8" "" "" "" "" "" "" "" "" "" "" "171.5" "191.1" "183.5" "140.1" "187.0" "212.3" "169.7" "175.2" "190.1" "134.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4929708673540461466" "False" "High" "IsMasterProtein" "Q9UHP3" "Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4" "0.000" "False" "15.698" "4" "4" "4" "4" "1055" "122.1" "5.34" "12.22" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443, Pf02809" "29761" "ENSG00000155313" "USP25" "C0LSZ0; hsa:29761; Q6DHZ9; Q9H9W1; Q9UHP3" "Ub-specific processing proteases" "" "1" "0" "1.022" "0.878" "1.360" "0.980" "0.876" "1.038" "0.888" "0.813" "1.314" "238.3" "243.5" "209.1" "324.0" "233.5" "208.7" "247.3" "211.6" "193.8" "313.1" "" "" "" "" "" "" "" "" "" "" "211.3" "201.7" "182.5" "242.3" "194.7" "191.8" "209.0" "174.9" "177.7" "313.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311968132693307525" "False" "High" "IsMasterProtein" "P42773" "Cyclin-dependent kinase 4 inhibitor C OS=Homo sapiens OX=9606 GN=CDKN2C PE=1 SV=1" "0.000" "False" "15.692" "25" "5" "10" "5" "168" "18.1" "6.52" "28.74" "5" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12796" "1031" "ENSG00000123080" "CDKN2C" "hsa:1031; P42773; Q8TB83" "Oncogene Induced Senescence; Oxidative Stress Induced Senescence; Cyclin D associated events in G1; Senescence-Associated Secretory Phenotype (SASP)" "Cell cycle; Glioblastoma signaling pathways; Vitamin D receptor pathway; G1 to S cell cycle control" "8" "0" "0.917" "0.890" "0.868" "0.866" "0.991" "0.900" "0.908" "0.918" "0.399" "1278.4" "1171.9" "1137.4" "1109.0" "1106.7" "1267.3" "1151.2" "1160.5" "1174.1" "510.1" "" "" "" "" "" "" "" "" "" "" "1133.7" "970.7" "992.4" "829.4" "922.8" "1164.1" "972.9" "959.2" "1076.8" "510.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.000" "False" "15.684" "5" "3" "3" "3" "621" "68.7" "7.96" "10.65" "3" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Complex I biogenesis" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "3" "0" "0.938" "0.803" "0.910" "0.898" "0.876" "0.870" "0.836" "0.729" "1.378" "171.2" "160.6" "137.5" "155.8" "153.7" "150.0" "149.0" "143.2" "124.9" "235.9" "" "" "" "" "" "" "" "" "" "" "151.9" "133.1" "120.0" "116.5" "128.2" "137.8" "125.9" "118.4" "114.5" "235.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5249914492597377912" "False" "High" "IsMasterProtein" "Q8WV19" "Vesicle transport protein SFT2A OS=Homo sapiens OX=9606 GN=SFT2D1 PE=1 SV=1" "0.000" "False" "15.677" "17" "1" "1" "1" "159" "17.8" "8.65" "7.94" "1" "transport" "other membranes" "" "Pf04178" "113402" "ENSG00000198818" "SFT2D1" "hsa:113402; Q5TI64; Q8WV19; Q9UIC7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "15.653" "13" "2" "2" "2" "252" "25.4" "9.88" "11.21" "2" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "1.187" "1.326" "1.183" "1.108" "1.262" "1.288" "1.292" "1.305" "1.413" "45.1" "53.5" "59.7" "53.3" "49.9" "56.9" "58.0" "58.2" "58.8" "63.7" "" "" "" "" "" "" "" "" "" "" "40.0" "44.3" "52.1" "39.9" "41.6" "52.2" "49.0" "48.1" "53.9" "63.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1129418023889810362" "False" "High" "IsMasterProtein" "P40429" "Large ribosomal subunit protein uL13 OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2" "0.000" "False" "15.653" "16" "4" "5" "4" "203" "23.6" "10.93" "16.91" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00572" "23521" "ENSG00000142541" "RPL13A" "A8K505; hsa:23521; P40429" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "1.126" "1.036" "0.975" "1.158" "1.042" "0.968" "0.972" "0.980" "1.077" "622.1" "700.4" "644.4" "606.4" "720.4" "648.3" "602.2" "604.5" "609.7" "669.9" "" "" "" "" "" "" "" "" "" "" "551.6" "580.2" "562.3" "453.5" "600.8" "595.6" "509.0" "499.7" "559.2" "669.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7058356130293402746" "False" "High" "IsMasterProtein" "Q6ZRS2" "Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3" "0.000" "False" "15.621" "1" "3" "3" "3" "3230" "343.3" "5.96" "10.36" "3" "cell organization and biogenesis;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529" "10847" "ENSG00000080603" "SRCAP" "B0JZA6; hsa:10847; O15026; Q6ZRS2; Q7Z744; Q9Y5L9" "" "Pathways affected in adenoid cystic carcinoma" "1" "0" "1.217" "1.175" "1.304" "1.214" "1.179" "1.217" "0.966" "1.138" "2.802" "162.6" "198.0" "191.1" "212.0" "197.4" "191.6" "198.0" "157.0" "185.0" "455.7" "" "" "" "" "" "" "" "" "" "" "144.2" "164.0" "166.7" "158.5" "164.6" "176.0" "167.3" "129.8" "169.7" "455.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246556582121742605" "False" "High" "IsMasterProtein" "Q9P253" "Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2" "0.000" "False" "15.612" "3" "3" "3" "3" "973" "110.1" "6.07" "11.26" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05131" "57617" "ENSG00000104142" "VPS18" "hsa:57617; Q8TCG0; Q96DI3; Q9H268; Q9P253" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "3" "0" "1.267" "0.912" "1.232" "1.158" "0.960" "1.307" "0.539" "1.069" "11.776" "74.4" "94.2" "67.8" "91.6" "86.1" "71.3" "97.1" "40.1" "79.5" "875.6" "" "" "" "" "" "" "" "" "" "" "65.9" "78.0" "59.2" "68.5" "71.8" "65.5" "82.1" "33.1" "72.9" "875.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656121017139874826" "False" "High" "IsMasterProtein" "Q01081" "Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3" "0.000" "False" "15.598" "13" "3" "4" "3" "240" "27.9" "8.81" "16.02" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "102724594; 7307" "ENSG00000160201" "U2AF1" "hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway" "mRNA processing" "5" "0" "1.093" "1.029" "1.000" "1.041" "0.928" "0.930" "0.536" "1.035" "9.936" "269.6" "294.6" "277.3" "269.6" "280.6" "250.3" "250.8" "144.4" "279.1" "2678.4" "" "" "" "" "" "" "" "" "" "" "239.0" "244.1" "241.9" "201.6" "234.0" "229.9" "212.0" "119.3" "256.0" "2678.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8503334225233124721" "False" "High" "IsMasterProtein" "P78317" "E3 ubiquitin-protein ligase RNF4 OS=Homo sapiens OX=9606 GN=RNF4 PE=1 SV=1" "0.000" "False" "15.569" "21" "3" "6" "3" "190" "21.3" "7.03" "18.02" "3" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13639" "6047" "ENSG00000063978" "RNF4" "B2R6D6; D6RF58; P78317; Q49AR8" "Processing of DNA double-strand break ends; Antigen processing: Ubiquitination & Proteasome degradation" "Androgen receptor signaling pathway" "3" "0" "1.214" "1.048" "1.244" "1.035" "1.402" "1.153" "1.046" "1.328" "0.722" "30.4" "36.9" "31.9" "37.9" "31.5" "42.7" "35.1" "31.8" "40.4" "22.0" "" "" "" "" "" "" "" "" "" "" "27.0" "30.6" "27.8" "28.3" "26.3" "39.2" "29.6" "26.3" "37.1" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260092317082084293" "False" "High" "IsMasterProtein" "Q13362" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP2R5C PE=1 SV=3" "0.000" "False" "15.557" "10" "6" "7" "4" "524" "61.0" "6.87" "16.86" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5527" "ENSG00000078304" "PPP2R5C" "B4DYJ8; B5BUA5; F5GWP3; hsa:5527; Q13362; Q14391; Q15060; Q15174; Q6ZN33" "Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "29" "0" "0.884" "0.945" "1.034" "0.815" "0.764" "0.859" "0.770" "0.861" "2.486" "369.7" "327.0" "349.4" "382.1" "301.2" "282.4" "317.7" "284.8" "318.2" "919.0" "" "" "" "" "" "" "" "" "" "" "327.8" "270.8" "304.8" "285.8" "251.2" "259.4" "268.5" "235.4" "291.9" "919.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2341580766278944773" "False" "High" "IsMasterProtein" "P15056" "Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4" "0.000" "False" "15.533" "6" "5" "6" "2" "766" "84.4" "7.53" "16.34" "5" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "673" "ENSG00000157764" "BRAF" "A4D1T4; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66; hsa:673; P15056; Q13878; Q3MIN6; Q9UDP8; Q9Y6T3" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Spry regulation of FGF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; Signalling to p38 via RIT and RIN; Negative feedback regulation of MAPK pathway" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Polycystic kidney disease pathway; Bladder cancer; Focal adhesion; BDNF-TrkB signaling; MAPK signaling pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Rett syndrome; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; MAPK pathway in congenital thyroid cancer; TCA cycle in senescence; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; ErbB signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "56" "3" "0.945" "1.066" "1.129" "1.117" "1.115" "1.628" "1.495" "1.571" "2.436" "358.0" "338.3" "381.5" "404.4" "399.8" "399.4" "582.8" "535.4" "562.3" "872.4" "" "" "" "" "" "" "" "" "" "" "317.5" "280.2" "332.9" "302.4" "333.4" "366.9" "492.6" "442.6" "515.7" "872.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4153058016593714536" "False" "High" "IsMasterProtein" "Q9UKT5" "F-box only protein 4 OS=Homo sapiens OX=9606 GN=FBXO4 PE=1 SV=2" "0.000" "False" "15.501" "9" "3" "3" "3" "387" "44.1" "6.16" "13.50" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646" "26272" "ENSG00000151876" "FBXO4" "hsa:26272; Q68CU8; Q86VT8; Q9UK98; Q9UKT5" "Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "3" "0" "0.921" "0.859" "0.950" "0.966" "0.985" "0.956" "1.070" "1.002" "1.053" "105.0" "96.7" "90.2" "99.8" "101.4" "103.5" "100.4" "112.4" "105.2" "110.6" "" "" "" "" "" "" "" "" "" "" "93.1" "80.1" "78.7" "74.6" "84.6" "95.1" "84.9" "92.9" "96.5" "110.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "524672605360435536" "False" "High" "IsMasterProtein" "O95273" "Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2" "0.000" "False" "15.492" "6" "2" "3" "2" "360" "40.2" "4.82" "11.58" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf13324, Pf20936" "23582" "ENSG00000166946" "CCNDBP1" "A8K3Q0; A8K3U2; hsa:23582; O95273; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3; Q9UHX9" "" "" "0" "0" "0.887" "0.990" "1.040" "0.984" "0.966" "1.090" "0.985" "1.015" "2.660" "299.2" "265.4" "296.2" "311.1" "294.3" "289.1" "326.1" "294.8" "303.6" "796.0" "" "" "" "" "" "" "" "" "" "" "265.4" "219.8" "258.4" "232.6" "245.4" "265.6" "275.6" "243.6" "278.5" "796.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "High" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.000" "False" "15.466" "10" "3" "5" "3" "411" "46.5" "6.96" "19.45" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "Regulation of expression of SLITs and ROBOs; Expression and translocation of olfactory receptors; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cardiogenesis" "" "4" "0" "0.841" "1.056" "0.898" "0.992" "1.042" "0.850" "0.944" "1.085" "0.579" "109.7" "92.3" "115.9" "98.5" "108.8" "114.3" "93.3" "103.6" "119.1" "63.6" "" "" "" "" "" "" "" "" "" "" "97.3" "76.4" "101.1" "73.7" "90.8" "105.0" "78.8" "85.6" "109.2" "63.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "683503187076847751" "False" "High" "IsMasterProtein" "Q96AZ6" "Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2" "0.000" "False" "15.434" "23" "4" "4" "4" "181" "20.4" "8.92" "13.58" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "3669" "ENSG00000172183" "ISG20" "hsa:3669; O00441; O00586; Q96AZ6" "Interferon alpha/beta signaling" "" "1" "0" "1.009" "0.866" "0.814" "0.783" "0.923" "0.825" "0.606" "0.900" "3.727" "40.4" "40.7" "35.0" "32.9" "31.6" "37.3" "33.3" "24.5" "36.3" "150.6" "" "" "" "" "" "" "" "" "" "" "35.8" "33.8" "30.5" "24.6" "26.4" "34.3" "28.2" "20.3" "33.3" "150.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2927225253202889871" "False" "High" "IsMasterProtein" "P20701" "Integrin alpha-L OS=Homo sapiens OX=9606 GN=ITGAL PE=1 SV=3" "0.000" "False" "15.428" "4" "4" "4" "4" "1170" "128.7" "5.63" "15.04" "4" "cell adhesion;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00092, Pf00357, Pf01839, Pf08441, Pf20805" "3683" "ENSG00000005844" "ITGAL" "hsa:3683; O43746; P20701; Q45H73; Q96HB1; Q9UBC8" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; RUNX3 Regulates Immune Response and Cell Migration" "Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway" "11" "0" "1.029" "1.044" "1.276" "1.125" "1.027" "1.159" "1.085" "1.227" "0.796" "292.2" "300.7" "305.2" "373.0" "328.7" "300.1" "338.8" "317.1" "358.5" "232.5" "" "" "" "" "" "" "" "" "" "" "259.1" "249.1" "266.3" "278.9" "274.1" "275.6" "286.3" "262.1" "328.8" "232.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1584990058854155939" "False" "High" "IsMasterProtein" "Q9NPI6" "mRNA-decapping enzyme 1A OS=Homo sapiens OX=9606 GN=DCP1A PE=1 SV=3" "0.000" "False" "15.418" "12" "4" "4" "4" "582" "63.2" "6.25" "11.34" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "55802" "ENSG00000272886" "DCP1A" "B4DHN9; hsa:55802; Q9NPI6; U3KQM8" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; mRNA decay by 5' to 3' exoribonuclease; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "TGF-beta signaling pathway" "5" "0" "1.009" "0.908" "1.075" "0.990" "0.989" "0.952" "0.927" "0.882" "1.740" "409.9" "413.4" "372.0" "440.6" "405.7" "405.4" "390.4" "380.0" "361.5" "713.0" "" "" "" "" "" "" "" "" "" "" "363.5" "342.4" "324.6" "329.5" "338.3" "372.4" "329.9" "314.1" "331.5" "713.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6853510993854323375" "False" "High" "IsMasterProtein" "Q9H7J1" "Protein phosphatase 1 regulatory subunit 3E OS=Homo sapiens OX=9606 GN=PPP1R3E PE=1 SV=2" "0.000" "False" "15.383" "14" "3" "3" "3" "279" "30.6" "11.15" "14.05" "3" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf03370" "90673" "ENSG00000235194" "PPP1R3E" "D3DS47; hsa:90673; Q9H7J1" "" "" "0" "0" "1.024" "0.978" "1.077" "0.953" "0.959" "1.088" "1.019" "0.983" "1.004" "176.3" "180.5" "172.4" "190.0" "168.0" "169.0" "191.8" "179.7" "173.4" "177.0" "" "" "" "" "" "" "" "" "" "" "156.4" "149.5" "150.4" "142.1" "140.1" "155.3" "162.1" "148.5" "159.0" "177.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283979429673317137" "False" "High" "IsMasterProtein" "A6NIH7" "Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1" "0.000" "False" "15.357" "14" "3" "5" "3" "251" "28.1" "5.68" "20.80" "3" "cell organization and biogenesis;transport;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05351" "84747" "ENSG00000175970" "UNC119B" "A6NIH7; hsa:84747" "Trafficking of myristoylated proteins to the cilium" "" "1" "0" "1.051" "1.041" "1.041" "1.050" "1.046" "1.042" "0.980" "1.014" "1.759" "347.1" "364.9" "361.3" "361.3" "364.3" "363.2" "361.7" "340.1" "352.2" "610.6" "" "" "" "" "" "" "" "" "" "" "307.8" "302.3" "315.3" "270.2" "303.8" "333.6" "305.7" "281.1" "323.0" "610.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "212659989141045460" "False" "High" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "0.000" "False" "15.353" "8" "4" "4" "4" "416" "47.3" "7.33" "11.91" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "6" "0" "0.896" "1.036" "0.843" "0.928" "0.943" "0.915" "0.880" "0.849" "1.014" "158.5" "142.0" "164.2" "133.6" "147.1" "149.5" "145.0" "139.5" "134.5" "160.7" "" "" "" "" "" "" "" "" "" "" "140.6" "117.6" "143.3" "99.9" "122.6" "137.3" "122.6" "115.3" "123.4" "160.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7494983611247909195" "False" "High" "IsMasterProtein" "O15394" "Neural cell adhesion molecule 2 OS=Homo sapiens OX=9606 GN=NCAM2 PE=1 SV=2" "0.000" "False" "15.345" "5" "5" "6" "5" "837" "93.0" "5.60" "19.92" "5" "cell adhesion;cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00041, Pf07679, Pf13927" "4685" "ENSG00000154654" "NCAM2" "A8MQ06; B7Z841; hsa:4685; O15394; Q7Z7F2" "" "" "0" "0" "1.039" "0.899" "1.005" "0.985" "1.000" "1.011" "0.933" "1.009" "0.787" "392.2" "407.7" "352.7" "394.3" "386.4" "392.4" "396.5" "366.0" "395.7" "308.5" "" "" "" "" "" "" "" "" "" "" "347.8" "337.7" "307.8" "294.9" "322.2" "360.5" "335.1" "302.5" "362.9" "308.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3102131592095934236" "False" "High" "IsMasterProtein" "Q969G6" "Riboflavin kinase OS=Homo sapiens OX=9606 GN=RFK PE=1 SV=2" "0.000" "False" "15.327" "19" "3" "5" "3" "155" "17.6" "8.13" "15.17" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01687" "55312" "ENSG00000135002" "RFK" "hsa:55312; Q5JSG9; Q969G6; Q9NUT7" "Vitamin B2 (riboflavin) metabolism" "Selenium micronutrient network; Folate metabolism; TNF-alpha signaling pathway" "4" "0" "1.001" "0.992" "1.040" "0.998" "1.024" "1.048" "1.098" "1.003" "0.516" "1027.8" "1028.5" "1019.4" "1068.8" "1026.1" "1052.0" "1077.5" "1128.4" "1031.0" "530.2" "" "" "" "" "" "" "" "" "" "" "911.4" "852.0" "889.5" "799.3" "855.7" "966.3" "910.6" "932.7" "945.6" "530.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "15.311" "13" "5" "5" "5" "408" "45.9" "6.18" "16.19" "5" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "Thyroxine (thyroid hormone) production" "4" "0" "1.078" "1.092" "1.082" "1.058" "1.071" "1.118" "1.044" "1.044" "0.692" "298.1" "321.5" "325.5" "322.7" "315.3" "319.2" "333.2" "311.3" "311.3" "206.3" "" "" "" "" "" "" "" "" "" "" "264.4" "266.3" "284.0" "241.4" "262.9" "293.2" "281.6" "257.3" "285.5" "206.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265901885640742242" "False" "High" "IsMasterProtein" "Q03164" "Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5" "0.000" "False" "15.293" "1" "5" "6" "5" "3969" "431.5" "9.09" "16.56" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "4297" "ENSG00000118058" "KMT2A" "E9PQG7; hsa:4297; Q03164; Q13743; Q13744; Q14845; Q16364; Q59FF2; Q6UBD1; Q9HBJ3; Q9UD94; Q9UMA3" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis" "Histone modifications" "6" "0" "1.018" "0.900" "1.000" "0.961" "0.915" "0.953" "0.699" "0.746" "0.888" "61.7" "62.8" "55.5" "61.6" "59.3" "56.5" "58.8" "43.1" "46.0" "54.8" "" "" "" "" "" "" "" "" "" "" "54.7" "52.0" "48.4" "46.1" "49.4" "51.9" "49.7" "35.6" "42.2" "54.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-21239567639981216" "False" "High" "IsMasterProtein" "Q9BRA0" "N-alpha-acetyltransferase 38, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA38 PE=1 SV=1" "0.000" "False" "15.239" "30" "3" "3" "3" "125" "13.5" "5.53" "11.09" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "84316" "ENSG00000183011" "NAA38" "hsa:84316; Q8N4M0; Q9BRA0" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967906594537230573" "False" "High" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "0.000" "False" "15.216" "24" "3" "4" "3" "133" "15.5" "6.06" "15.91" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "0.869" "0.954" "0.968" "0.958" "0.991" "0.886" "0.929" "0.949" "1.035" "178.9" "155.4" "170.7" "173.2" "171.5" "177.2" "158.5" "166.2" "169.7" "185.1" "" "" "" "" "" "" "" "" "" "" "158.6" "128.7" "148.9" "129.5" "143.0" "162.8" "133.9" "137.3" "155.6" "185.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7135249905505884321" "False" "High" "IsMasterProtein" "P0DTL6" "Zinc finger TRAF-type-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFTRAF1 PE=1 SV=1" "0.000" "False" "15.215" "14" "5" "7" "5" "404" "43.8" "6.76" "17.65" "5" "" "nucleus;other cell component" "other molecular function" "" "157542; 50626; 84773" "ENSG00000187954" "ZFTRAF1" "B3KSX0; D3DWM3; E9PJD7; hsa:157542; hsa:50626; hsa:84773; P0DTL6; Q6ZMK1; Q9BSF6; Q9BSU6" "" "" "0" "0" "1.028" "0.990" "0.947" "0.953" "0.998" "0.944" "0.932" "0.969" "0.608" "516.8" "531.1" "511.4" "489.4" "492.4" "515.5" "487.6" "481.9" "501.0" "314.0" "" "" "" "" "" "" "" "" "" "" "458.3" "439.9" "446.3" "366.0" "410.6" "473.5" "412.1" "398.3" "459.5" "314.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-323839447441261697" "False" "High" "IsMasterProtein" "Q9NWK9" "Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1" "0.000" "False" "15.191" "7" "3" "3" "3" "470" "53.9" "5.80" "11.70" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "54680" "ENSG00000117174" "ZNHIT6" "B2RBA1; B4DP13; D3DT20; hsa:54680; Q9H278; Q9H3X3; Q9NWK9; Q9NWN0" "" "" "0" "0" "0.926" "0.863" "0.922" "1.024" "1.033" "0.917" "0.836" "0.983" "2.210" "440.7" "408.2" "380.3" "406.1" "451.1" "455.1" "403.9" "368.5" "433.0" "973.8" "" "" "" "" "" "" "" "" "" "" "390.8" "338.1" "331.8" "303.7" "376.2" "418.0" "341.4" "304.6" "397.1" "973.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4527223765443096832" "False" "High" "IsMasterProtein" "O95785" "Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2" "0.000" "False" "15.175" "3" "4" "4" "4" "1651" "178.6" "6.86" "13.09" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "58525" "ENSG00000011451" "WIZ" "B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1" "" "" "0" "0" "0.923" "0.947" "0.899" "1.021" "1.005" "1.107" "0.890" "1.003" "1.129" "217.2" "200.5" "205.7" "195.3" "221.6" "218.2" "240.4" "193.4" "217.9" "245.3" "" "" "" "" "" "" "" "" "" "" "192.6" "166.1" "179.5" "146.1" "184.8" "200.5" "203.2" "159.8" "199.8" "245.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3305508852960409357" "False" "High" "IsMasterProtein" "Cont_Q7SIH1" "Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2" "0.000" "True" "15.167" "3" "4" "4" "4" "1510" "167.5" "6.02" "13.46" "4" "" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791" "513856" "" "A2M" "A8E647; bta:513856; Q7SIH1" "" "" "0" "0" "1.058" "0.924" "1.116" "1.050" "1.045" "1.092" "1.076" "0.851" "0.856" "240.3" "254.3" "222.2" "268.3" "252.3" "251.1" "262.4" "258.5" "204.5" "205.7" "" "" "" "" "" "" "" "" "" "" "213.1" "210.6" "193.9" "200.7" "210.4" "230.7" "221.8" "213.7" "187.6" "205.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8417991388953307590" "False" "High" "IsMasterProtein" "O75064" "DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4" "0.000" "False" "15.156" "3" "5" "5" "5" "1496" "163.7" "7.21" "16.71" "5" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "9909" "ENSG00000198837" "DENND4B" "hsa:9909; O75064; Q5T4K0" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.887" "0.926" "0.897" "0.774" "0.720" "0.715" "0.881" "0.865" "1.078" "191.3" "169.7" "177.2" "171.6" "148.0" "137.8" "136.7" "168.5" "165.4" "206.3" "" "" "" "" "" "" "" "" "" "" "169.7" "140.6" "154.6" "128.3" "123.4" "126.6" "115.6" "139.3" "151.7" "206.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2137226823831967498" "False" "High" "IsMasterProtein" "Q0VD83" "Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3" "0.000" "False" "15.148" "4" "4" "5" "4" "1097" "115.6" "4.40" "15.97" "4" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "" "55911" "ENSG00000184730" "APOBR" "H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9" "VLDL clearance" "" "1" "0" "0.967" "1.062" "1.074" "1.023" "0.980" "0.940" "1.069" "1.059" "0.446" "106.1" "102.6" "112.8" "114.0" "108.6" "104.0" "99.8" "113.5" "112.4" "47.3" "" "" "" "" "" "" "" "" "" "" "94.1" "85.0" "98.4" "85.2" "90.5" "95.5" "84.3" "93.8" "103.1" "47.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6579369189662832735" "False" "High" "IsMasterProtein" "Q8IX04" "Ubiquitin-conjugating enzyme E2 variant 3 OS=Homo sapiens OX=9606 GN=UEVLD PE=1 SV=2" "0.000" "False" "15.142" "9" "3" "3" "3" "471" "52.2" "7.09" "12.46" "3" "protein metabolism;other metabolic processes;transport" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00056, Pf02866, Pf05743" "55293" "ENSG00000151116" "UEVLD" "B2RB69; B4DL43; F5H6L6; H7BYD6; hsa:55293; Q6P2F0; Q8IX04; Q96FF5; Q9NUX7" "" "" "0" "0" "1.057" "0.997" "1.040" "0.916" "1.015" "0.960" "0.858" "1.068" "3.169" "444.7" "470.0" "443.4" "462.4" "407.4" "451.4" "427.1" "381.5" "474.8" "1409.1" "" "" "" "" "" "" "" "" "" "" "394.4" "389.3" "386.9" "345.8" "339.7" "414.7" "361.0" "315.3" "435.4" "1409.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "15.126" "18" "4" "5" "4" "193" "21.7" "5.39" "15.31" "4" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.989" "0.915" "0.962" "0.903" "0.798" "0.993" "0.790" "0.916" "2.753" "505.1" "499.6" "462.3" "485.8" "455.8" "403.1" "501.7" "399.0" "462.4" "1390.7" "" "" "" "" "" "" "" "" "" "" "447.9" "413.8" "403.4" "363.3" "380.1" "370.3" "424.0" "329.8" "424.1" "1390.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2500202292612525864" "False" "High" "IsMasterProtein" "Q99623" "Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2" "0.000" "False" "15.118" "7" "2" "2" "2" "299" "33.3" "9.83" "8.47" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01145" "11331" "ENSG00000215021" "PHB2" "B4DP75; hsa:11331; Q2YDA4; Q7KYU3; Q92978; Q99623" "Processing of SMDT1; Cellular response to mitochondrial stress" "" "2" "0" "0.465" "0.162" "0.286" "0.290" "0.274" "0.217" "0.193" "0.322" "0.167" "498.7" "232.1" "80.6" "142.4" "144.5" "136.9" "108.0" "96.1" "160.6" "83.4" "" "" "" "" "" "" "" "" "" "" "442.2" "192.3" "70.3" "106.5" "120.5" "125.7" "91.3" "79.4" "147.2" "83.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-303142054863253165" "False" "High" "IsMasterProtein" "Q67FW5" "Queuosine-tRNA galactosyltransferase OS=Homo sapiens OX=9606 GN=B3GNTL1 PE=1 SV=3" "0.000" "False" "15.116" "14" "5" "6" "5" "346" "39.4" "7.78" "19.84" "5" "" "" "other molecular function" "Pf00535" "146712" "ENSG00000175711; ENSG00000277033" "B3GNTL1" "hsa:146712; Q67FW5; Q6GV30; Q8WUT3" "O-linked glycosylation of mucins" "" "1" "0" "0.968" "0.838" "0.934" "0.792" "0.860" "0.810" "0.805" "0.841" "0.642" "445.4" "431.1" "373.2" "416.0" "352.6" "383.1" "360.8" "358.7" "374.7" "286.0" "" "" "" "" "" "" "" "" "" "" "395.0" "357.1" "325.7" "311.1" "294.1" "351.9" "305.0" "296.5" "343.6" "286.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397574204075436679" "False" "High" "IsMasterProtein" "Q15013" "MAD2L1-binding protein OS=Homo sapiens OX=9606 GN=MAD2L1BP PE=1 SV=1" "0.000" "False" "15.106" "14" "2" "3" "2" "274" "31.0" "6.30" "12.85" "2" "other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06581" "9587" "ENSG00000124688" "MAD2L1BP" "B4DLV3; E9PAT7; hsa:9587; Q15013; Q6IBB1" "" "3q29 copy number variation syndrome" "1" "0" "0.964" "0.885" "0.929" "0.780" "0.740" "0.721" "0.813" "0.890" "0.798" "237.8" "229.3" "210.6" "220.9" "185.5" "176.0" "171.4" "193.3" "211.7" "189.8" "" "" "" "" "" "" "" "" "" "" "210.9" "189.9" "183.7" "165.2" "154.7" "161.6" "144.8" "159.8" "194.2" "189.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "High" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.000" "False" "15.098" "7" "3" "3" "3" "434" "50.5" "11.33" "11.89" "3" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "0.982" "0.961" "1.200" "1.129" "0.977" "1.097" "1.143" "1.162" "0.755" "265.4" "260.7" "255.2" "318.5" "299.7" "259.2" "291.1" "303.3" "308.5" "200.4" "" "" "" "" "" "" "" "" "" "" "235.3" "216.0" "222.6" "238.2" "249.9" "238.1" "246.0" "250.7" "282.9" "200.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8125851440420054284" "False" "High" "IsMasterProtein" "Q86UT8" "Centrosomal AT-AC splicing factor OS=Homo sapiens OX=9606 GN=CENATAC PE=1 SV=1" "0.000" "False" "15.075" "11" "3" "3" "3" "332" "38.0" "8.22" "11.10" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf14968" "338657" "ENSG00000186166; ENSG00000280975" "CENATAC" "hsa:338657; Q86UT8" "" "" "0" "0" "1.393" "0.901" "1.226" "0.999" "1.113" "1.213" "1.051" "0.841" "0.848" "59.0" "82.2" "53.2" "72.4" "59.0" "65.7" "71.6" "62.1" "49.7" "50.1" "" "" "" "" "" "" "" "" "" "" "52.4" "68.1" "46.4" "54.1" "49.2" "60.4" "60.5" "51.3" "45.5" "50.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-559088974634696514" "False" "High" "IsMasterProtein" "P13598" "Intercellular adhesion molecule 2 OS=Homo sapiens OX=9606 GN=ICAM2 PE=1 SV=2" "0.000" "False" "15.075" "14" "4" "4" "4" "275" "30.6" "7.43" "13.92" "4" "cell adhesion" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf03921" "3384" "ENSG00000108622" "ICAM2" "hsa:3384; P13598; Q14600" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "Complement system; Ebola virus infection in host" "5" "0" "1.134" "1.038" "1.154" "1.070" "1.035" "1.080" "1.120" "1.035" "0.357" "481.9" "546.4" "500.3" "556.2" "515.8" "498.9" "520.5" "539.5" "498.8" "172.2" "" "" "" "" "" "" "" "" "" "" "427.3" "452.7" "436.6" "416.0" "430.1" "458.2" "439.9" "446.0" "457.4" "172.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1475037397769826540" "False" "High" "IsMasterProtein" "O75817" "Ribonuclease P protein subunit p20 OS=Homo sapiens OX=9606 GN=POP7 PE=1 SV=2" "0.000" "False" "15.068" "16" "2" "3" "2" "140" "15.6" "8.94" "7.89" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12328" "10248" "ENSG00000172336" "POP7" "A4D2E0; hsa:10248; O75817; Q9BV74" "tRNA processing in the nucleus" "" "1" "0" "0.987" "0.956" "0.882" "0.834" "0.912" "0.970" "0.824" "1.018" "0.673" "212.8" "209.9" "203.5" "187.6" "177.5" "194.0" "206.4" "175.4" "216.6" "143.3" "" "" "" "" "" "" "" "" "" "" "188.7" "173.9" "177.6" "140.3" "148.0" "178.2" "174.4" "145.0" "198.7" "143.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4721604686666439752" "False" "High" "IsMasterProtein" "P07947" "Tyrosine-protein kinase Yes OS=Homo sapiens OX=9606 GN=YES1 PE=1 SV=3" "0.000" "False" "15.057" "6" "4" "4" "1" "543" "60.8" "6.74" "14.06" "4" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "7525" "ENSG00000176105" "YES1" "A6NLB3; D3DUH1; hsa:7525; P07947" "FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; EPHB-mediated forward signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; Signaling by ERBB2; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; CD28 co-stimulation; PECAM1 interactions; CTLA4 inhibitory signaling" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; NRF2-ARE regulation; Gastrin signaling pathway; GDNF signaling" "22" "2" "1.136" "0.976" "1.072" "1.076" "1.079" "1.055" "0.991" "1.111" "2.359" "534.0" "606.9" "521.3" "572.7" "574.5" "576.5" "563.2" "529.2" "593.5" "1260.0" "" "" "" "" "" "" "" "" "" "" "473.6" "502.7" "454.9" "428.3" "479.0" "529.5" "476.0" "437.4" "544.4" "1260.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.000" "False" "15.052" "10" "4" "4" "4" "406" "46.9" "8.37" "13.54" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "" "2" "0" "1.014" "1.090" "1.109" "1.124" "1.057" "1.179" "1.099" "1.049" "1.323" "436.9" "442.8" "476.1" "484.6" "491.3" "461.9" "515.3" "480.2" "458.2" "577.9" "" "" "" "" "" "" "" "" "" "" "387.4" "366.8" "415.4" "362.4" "409.6" "424.3" "435.5" "396.9" "420.2" "577.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2805151388024258847" "False" "High" "IsMasterProtein" "Cont_Q28107" "Coagulation factor V OS=Bos taurus OX=9913 GN=F5 PE=1 SV=1" "0.000" "True" "15.040" "2" "4" "4" "4" "2211" "248.8" "5.83" "12.78" "4" "stress response;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00754, Pf06049, Pf07732" "280687" "" "F5" "bta:280687; Q28107; Q28108" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3476317971320699033" "False" "High" "IsMasterProtein" "O43156" "TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3" "0.000" "False" "15.033" "4" "4" "4" "4" "1089" "122.0" "5.97" "13.08" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf21547" "9675" "ENSG00000101407" "TTI1" "D6W4K3; hsa:9675; O43156; Q5JX67; Q96A38; Q9BR47; Q9H4K0" "" "Fragile X syndrome; Pleural mesothelioma" "2" "0" "0.992" "0.972" "1.057" "1.051" "0.991" "1.023" "1.082" "0.930" "1.445" "30.1" "29.9" "29.3" "31.9" "31.7" "29.9" "30.8" "32.6" "28.0" "43.6" "" "" "" "" "" "" "" "" "" "" "26.7" "24.8" "25.6" "23.8" "26.4" "27.4" "26.0" "26.9" "25.7" "43.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8346227288620115762" "False" "High" "IsMasterProtein" "Q86TN4" "tRNA 2'-phosphotransferase 1 OS=Homo sapiens OX=9606 GN=TRPT1 PE=1 SV=2" "0.000" "False" "15.021" "9" "2" "3" "2" "253" "27.7" "9.98" "10.51" "2" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01885" "83707" "ENSG00000149743" "TRPT1" "A8MU17; A8MYC9; F5H2B2; hsa:83707; Q86TN4; Q9BSB9" "" "" "0" "0" "1.211" "0.930" "1.191" "1.024" "1.068" "1.032" "0.996" "0.977" "1.148" "167.9" "203.3" "156.2" "200.0" "172.0" "179.4" "173.3" "167.3" "164.1" "192.8" "" "" "" "" "" "" "" "" "" "" "148.9" "168.4" "136.3" "149.6" "143.4" "164.8" "146.4" "138.3" "150.5" "192.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7201160367223049830" "False" "High" "IsMasterProtein" "Cont_Q3MHN5" "Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1" "0.000" "True" "14.998" "8" "4" "4" "4" "474" "53.3" "5.52" "11.08" "4" "transport" "non-structural extracellular;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00273, Pf09164" "530076" "" "GC" "bta:530076; Q3MHN5" "" "" "0" "0" "1.116" "1.081" "0.813" "1.056" "0.920" "0.928" "1.084" "1.077" "0.527" "199.7" "222.8" "215.8" "162.3" "210.9" "183.7" "185.4" "216.5" "215.0" "105.2" "" "" "" "" "" "" "" "" "" "" "177.1" "184.6" "188.3" "121.4" "175.9" "168.7" "156.7" "179.0" "197.2" "105.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2163956888383823018" "False" "High" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "0.000" "False" "14.990" "2" "2" "2" "2" "974" "110.4" "6.49" "8.05" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048, Pf20652" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "0.863" "0.806" "0.932" "0.913" "0.714" "0.813" "0.010" "0.782" "21.585" "30.4" "26.3" "24.5" "28.4" "27.8" "21.7" "24.7" "0.0" "23.8" "656.9" "" "" "" "" "" "" "" "" "" "" "27.0" "21.7" "21.4" "21.2" "23.2" "20.0" "20.9" "0.0" "21.8" "656.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9076326979726242055" "False" "High" "IsMasterProtein" "Q9P2K6" "Kelch-like protein 42 OS=Homo sapiens OX=9606 GN=KLHL42 PE=1 SV=2" "0.000" "False" "14.984" "7" "3" "3" "3" "505" "56.8" "5.74" "13.24" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf01344, Pf07707" "57542" "ENSG00000087448" "KLHL42" "hsa:57542; Q2VPK1; Q8N334; Q9P2K6" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.058" "0.983" "1.104" "1.050" "1.024" "1.024" "1.033" "1.015" "0.937" "404.5" "428.1" "397.5" "446.4" "424.5" "414.2" "414.4" "417.7" "410.4" "379.0" "" "" "" "" "" "" "" "" "" "" "358.7" "354.6" "346.8" "333.9" "354.0" "380.5" "350.2" "345.3" "376.4" "379.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265190665490175279" "False" "High" "IsMasterProtein" "Q6IQ22" "Ras-related protein Rab-12 OS=Homo sapiens OX=9606 GN=RAB12 PE=1 SV=3" "0.000" "False" "14.981" "7" "2" "6" "1" "244" "27.2" "8.41" "21.97" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00071" "201475" "" "RAB12" "A6NEF5; hsa:201475; Q4KMQ3; Q6IQ22" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs" "" "2" "0" "1.183" "0.985" "1.183" "1.122" "0.956" "1.099" "1.017" "0.969" "0.739" "151.5" "179.2" "149.2" "179.2" "169.9" "144.8" "166.5" "154.1" "146.7" "111.9" "" "" "" "" "" "" "" "" "" "" "134.3" "148.5" "130.1" "134.0" "141.7" "133.0" "140.7" "127.3" "134.6" "111.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "High" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.000" "False" "14.967" "18" "3" "5" "3" "234" "26.2" "5.49" "22.23" "3" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "0.949" "1.064" "0.960" "1.052" "1.027" "0.973" "1.006" "0.948" "0.435" "1034.9" "982.3" "1101.2" "993.4" "1088.9" "1062.5" "1007.3" "1040.8" "981.5" "450.6" "" "" "" "" "" "" "" "" "" "" "917.7" "813.7" "960.9" "742.9" "908.0" "976.0" "851.4" "860.3" "900.2" "450.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6723656292985318404" "False" "High" "IsMasterProtein" "Q9Y255" "PRELI domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PRELID1 PE=1 SV=1" "0.000" "False" "14.954" "19" "5" "6" "5" "219" "25.2" "9.54" "19.73" "5" "cell organization and biogenesis;transport;other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf04707" "27166" "ENSG00000169230" "PRELID1" "B2R5F7; D6RD25; hsa:27166; Q549N2; Q9UI13; Q9UJS9; Q9Y255" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "5q35 copy number variation" "3" "0" "0.987" "0.956" "0.951" "0.908" "1.051" "0.971" "0.841" "0.913" "0.532" "443.4" "437.6" "423.7" "421.8" "402.6" "465.9" "430.4" "372.7" "404.8" "235.9" "" "" "" "" "" "" "" "" "" "" "393.2" "362.5" "369.7" "315.5" "335.7" "427.9" "363.7" "308.1" "371.2" "235.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1879771635680972276" "False" "High" "IsMasterProtein" "O95208" "Epsin-2 OS=Homo sapiens OX=9606 GN=EPN2 PE=1 SV=3" "0.000" "False" "14.942" "5" "3" "4" "3" "641" "68.4" "7.52" "15.60" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "22905" "ENSG00000072134" "EPN2" "A8MTV8; B3KRX8; E9PBC2; hsa:22905; O95207; O95208; Q52LD0; Q9H7Z2; Q9UPT7" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "1.012" "0.941" "0.993" "0.960" "0.984" "0.949" "0.921" "0.898" "0.633" "425.7" "430.8" "400.4" "422.8" "408.6" "419.0" "404.0" "392.0" "382.3" "269.6" "" "" "" "" "" "" "" "" "" "" "377.5" "356.8" "349.4" "316.2" "340.7" "384.9" "341.4" "324.0" "350.7" "269.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "14.937" "17" "6" "6" "6" "299" "33.3" "7.52" "13.21" "6" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "Urea cycle" "" "1" "0" "1.276" "1.103" "1.140" "1.228" "1.318" "1.273" "1.099" "1.054" "1.532" "107.0" "136.6" "118.1" "122.0" "131.4" "141.1" "136.2" "117.6" "112.8" "164.0" "" "" "" "" "" "" "" "" "" "" "94.9" "113.1" "103.0" "91.2" "109.5" "129.6" "115.1" "97.2" "103.4" "164.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6309414575858280989" "False" "High" "IsMasterProtein" "Q9GZQ3" "COMM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=COMMD5 PE=1 SV=1" "0.000" "False" "14.934" "12" "3" "3" "3" "224" "24.7" "7.02" "10.85" "3" "" "cytosol;nucleus" "" "Pf07258, Pf21672" "28991" "ENSG00000170619" "COMMD5" "D3DWN7; hsa:28991; Q9GZQ3; Q9NVN6; Q9UHX5" "Neddylation" "" "1" "0" "1.073" "1.014" "0.949" "0.996" "1.075" "1.000" "1.023" "0.842" "0.802" "393.1" "421.8" "398.6" "373.0" "391.5" "422.6" "393.2" "402.2" "331.0" "315.3" "" "" "" "" "" "" "" "" "" "" "348.6" "349.4" "347.8" "279.0" "326.5" "388.2" "332.3" "332.4" "303.6" "315.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.000" "False" "14.925" "10" "3" "3" "3" "437" "49.6" "8.12" "9.59" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.976" "1.086" "0.936" "0.942" "0.982" "1.070" "0.967" "1.026" "0.598" "188.2" "183.8" "204.4" "176.2" "177.4" "184.9" "201.4" "182.1" "193.2" "112.5" "" "" "" "" "" "" "" "" "" "" "166.9" "152.2" "178.3" "131.8" "147.9" "169.9" "170.2" "150.5" "177.2" "112.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.000" "False" "14.918" "8" "4" "5" "3" "448" "47.3" "5.88" "17.16" "4" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenocysteine synthesis" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "3" "0" "1.060" "1.020" "1.115" "1.010" "1.066" "1.074" "1.029" "1.029" "0.638" "298.1" "315.9" "304.0" "332.4" "301.2" "317.8" "320.0" "306.7" "306.7" "190.0" "" "" "" "" "" "" "" "" "" "" "264.3" "261.7" "265.2" "248.6" "251.1" "291.9" "270.5" "253.5" "281.3" "190.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "14.903" "20" "2" "9" "2" "102" "11.8" "4.70" "27.20" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "0.933" "0.913" "1.058" "0.943" "0.912" "1.003" "0.883" "0.962" "0.455" "356.1" "332.3" "325.1" "376.8" "335.6" "324.8" "357.2" "314.3" "342.7" "162.2" "" "" "" "" "" "" "" "" "" "" "315.8" "275.2" "283.6" "281.8" "279.9" "298.4" "301.9" "259.8" "314.3" "162.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256308892199755457" "False" "High" "IsMasterProtein" "Q969J3" "BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1" "0.000" "False" "14.898" "22" "4" "5" "4" "196" "22.2" "6.35" "14.12" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf10158" "118426" "ENSG00000165714; ENSG00000280689" "BORCS5" "hsa:118426; Q969J3; Q96QS5" "" "" "0" "0" "1.007" "1.073" "0.972" "1.041" "1.100" "0.945" "1.069" "1.083" "0.708" "619.5" "624.1" "664.6" "602.1" "645.2" "681.2" "585.5" "662.2" "670.7" "438.7" "" "" "" "" "" "" "" "" "" "" "549.4" "516.9" "579.9" "450.3" "538.0" "625.7" "494.8" "547.4" "615.1" "438.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "592112739915171791" "False" "High" "IsMasterProtein" "Q8NCG7" "Diacylglycerol lipase-beta OS=Homo sapiens OX=9606 GN=DAGLB PE=1 SV=2" "0.000" "False" "14.870" "6" "3" "3" "3" "672" "73.7" "6.55" "8.06" "3" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf01764" "221955" "ENSG00000164535" "DAGLB" "A4D2P3; B3KV90; B4DQU0; hsa:221955; Q6PIX3; Q8N2N2; Q8N9S1; Q8NCG7; Q8TED3; Q8WXE6" "Arachidonate production from DAG" "Cannabinoid receptor signaling; ADHD and autism (ASD) linked metabolic pathways and SNP" "3" "0" "1.054" "0.847" "1.046" "1.150" "1.048" "1.145" "1.025" "0.968" "1.123" "253.8" "267.6" "215.0" "265.6" "291.8" "266.1" "290.7" "260.2" "245.7" "285.0" "" "" "" "" "" "" "" "" "" "" "225.1" "221.7" "187.6" "198.6" "243.3" "244.5" "245.6" "215.1" "225.4" "285.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6253369152743795153" "False" "High" "IsMasterProtein" "Q8TD16" "Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1" "0.000" "False" "14.863" "5" "5" "5" "5" "824" "93.5" "5.44" "16.61" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf09730" "23299" "ENSG00000185963" "BICD2" "hsa:23299; O75181; Q5TBQ2; Q5TBQ3; Q8TD16; Q96LH2; Q9BT84; Q9H561" "COPI-independent Golgi-to-ER retrograde traffic" "" "1" "0" "0.929" "0.787" "0.873" "0.779" "0.918" "0.876" "0.684" "0.909" "3.655" "522.3" "485.2" "411.1" "456.0" "407.0" "479.7" "457.3" "357.5" "475.0" "1908.9" "" "" "" "" "" "" "" "" "" "" "463.2" "401.9" "358.7" "341.0" "339.4" "440.7" "386.5" "295.5" "435.7" "1908.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2487485535113900715" "False" "High" "IsMasterProtein" "Q9UGK8" "Secretion-regulating guanine nucleotide exchange factor OS=Homo sapiens OX=9606 GN=SERGEF PE=1 SV=2" "0.000" "False" "14.855" "7" "2" "2" "2" "458" "49.0" "6.46" "9.87" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00415, Pf13540" "26297" "ENSG00000129158" "SERGEF" "hsa:26297; Q9UGK8; Q9UGK9" "" "" "0" "0" "0.984" "0.923" "1.259" "1.070" "1.148" "1.004" "0.836" "1.050" "1.004" "78.5" "77.3" "72.4" "98.8" "84.0" "90.1" "78.8" "65.6" "82.5" "78.8" "" "" "" "" "" "" "" "" "" "" "69.6" "64.0" "63.2" "73.9" "70.0" "82.8" "66.6" "54.3" "75.6" "78.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4425211315180123745" "False" "High" "IsMasterProtein" "P49768" "Presenilin-1 OS=Homo sapiens OX=9606 GN=PSEN1 PE=1 SV=1" "0.000" "False" "14.834" "6" "2" "4" "2" "467" "52.6" "5.31" "13.94" "2" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf01080" "5663" "ENSG00000080815" "PSEN1" "B2R6D3; hsa:5663; O95465; P49768; Q14762; Q15719; Q15720; Q96P33; Q9UIF0" "Neutrophil degranulation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3" "Alzheimer's disease and miRNA effects; Notch signaling; Canonical and non-canonical Notch signaling; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "22" "0" "0.961" "0.870" "1.003" "0.892" "0.955" "0.908" "0.836" "0.963" "0.370" "258.6" "248.6" "225.0" "259.5" "230.8" "247.0" "234.8" "216.1" "249.0" "95.8" "" "" "" "" "" "" "" "" "" "" "229.4" "206.0" "196.3" "194.1" "192.5" "226.9" "198.5" "178.7" "228.3" "95.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1889063708723088162" "False" "High" "IsMasterProtein" "O14772" "Fucose-1-phosphate guanylyltransferase OS=Homo sapiens OX=9606 GN=FPGT PE=1 SV=3" "0.000" "False" "14.801" "6" "4" "4" "4" "607" "68.0" "6.87" "13.32" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf07959" "8790" "ENSG00000254685" "FPGT" "A0A0A0MRP2; A6NMH3; B4DRX2; B4E2Y7; E9PNQ2; hsa:8790; O14772; Q8N5J7" "GDP-fucose biosynthesis" "" "1" "0" "1.033" "0.938" "1.167" "1.056" "0.997" "1.158" "1.018" "0.937" "0.690" "416.2" "430.2" "390.6" "485.8" "439.6" "415.1" "481.9" "423.9" "390.1" "287.0" "" "" "" "" "" "" "" "" "" "" "369.1" "356.3" "340.8" "363.3" "366.6" "381.3" "407.3" "350.4" "357.7" "287.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "14.798" "4" "4" "4" "4" "1136" "124.5" "6.10" "14.49" "4" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "Neutrophil degranulation; RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4571084566871798353" "False" "High" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "0.000" "False" "14.789" "25" "2" "13" "1" "64" "7.1" "9.99" "35.01" "2" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "0.871" "0.884" "0.827" "0.805" "0.958" "0.880" "0.833" "0.816" "0.323" "1851.9" "1612.8" "1637.5" "1531.8" "1490.6" "1773.5" "1630.6" "1542.1" "1511.4" "597.5" "" "" "" "" "" "" "" "" "" "" "1642.2" "1336.0" "1428.8" "1145.6" "1243.0" "1629.2" "1378.1" "1274.6" "1386.1" "597.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2661255315618113722" "False" "High" "IsMasterProtein" "O43493" "Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4" "0.000" "False" "14.788" "11" "4" "4" "4" "437" "45.9" "5.63" "13.37" "4" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf17818" "10618" "ENSG00000152291; ENSG00000292253" "TGOLN2" "B2R686; B8ZZ88; D6W5K3; F8W8W7; F8WBK2; hsa:10618; J3KQ45; O15282; O43492; O43493; O43499; O43500; O43501; Q53G68; Q53GV2; Q6MZV1; Q6ZTM7; Q8N6T8; Q92760; Q96QL2" "Golgi Associated Vesicle Biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "" "6" "0" "0.995" "0.866" "0.964" "0.924" "0.976" "0.941" "0.857" "0.959" "0.904" "333.2" "331.6" "288.5" "321.3" "307.8" "325.1" "313.6" "285.5" "319.5" "301.4" "" "" "" "" "" "" "" "" "" "" "295.5" "274.7" "251.7" "240.3" "256.7" "298.6" "265.0" "236.0" "293.0" "301.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "843171063376576291" "False" "High" "IsMasterProtein" "Q6P0Q8" "Microtubule-associated serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=MAST2 PE=1 SV=2" "0.000" "False" "14.786" "3" "6" "8" "5" "1798" "196.3" "8.16" "26.69" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08926, Pf17820" "23139" "ENSG00000086015" "MAST2" "hsa:23139; O94899; Q5VT07; Q5VT08; Q6P0Q8; Q7LGC4; Q8NDG1; Q96B94; Q9BYE8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3917086936507081280" "False" "High" "IsMasterProtein" "Q56P03" "E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4" "0.000" "False" "14.782" "16" "4" "5" "4" "285" "32.7" "5.12" "16.09" "4" "other biological processes" "nucleus;other cell component" "" "Pf10238" "55837" "ENSG00000129518" "EAPP" "hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86" "" "" "0" "0" "0.666" "0.608" "0.603" "0.581" "0.626" "0.654" "0.571" "0.630" "1.534" "465.3" "309.8" "282.7" "280.8" "270.4" "291.3" "304.5" "265.7" "293.0" "713.8" "" "" "" "" "" "" "" "" "" "" "412.6" "256.6" "246.7" "210.0" "225.5" "267.6" "257.3" "219.6" "268.7" "713.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723203762439641288" "False" "High" "IsMasterProtein" "Q9Y5N5" "Methyltransferase N6AMT1 OS=Homo sapiens OX=9606 GN=N6AMT1 PE=1 SV=4" "0.000" "False" "14.727" "14" "3" "3" "3" "214" "22.9" "5.11" "11.60" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29104" "ENSG00000156239" "N6AMT1" "B2RA97; hsa:29104; Q96F73; Q9Y5N5" "Eukaryotic Translation Termination; Methylation" "" "2" "0" "1.109" "1.048" "1.137" "1.026" "1.015" "1.074" "0.918" "1.049" "0.710" "76.5" "84.8" "80.1" "86.9" "78.5" "77.6" "82.1" "70.2" "80.2" "54.3" "" "" "" "" "" "" "" "" "" "" "67.8" "70.2" "69.9" "65.0" "65.4" "71.3" "69.4" "58.0" "73.5" "54.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.000" "False" "14.699" "6" "3" "5" "3" "499" "55.4" "5.78" "16.78" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "mRNA Splicing - Major Pathway" "" "1" "0" "1.345" "1.262" "2.067" "1.414" "1.204" "1.597" "0.891" "1.230" "8.039" "20.8" "28.0" "26.3" "43.1" "29.5" "25.1" "33.3" "18.6" "25.7" "167.6" "" "" "" "" "" "" "" "" "" "" "18.5" "23.2" "23.0" "32.2" "24.6" "23.1" "28.1" "15.4" "23.5" "167.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8712581138028706155" "False" "High" "IsMasterProtein" "Cont_P02081" "Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1" "0.000" "True" "14.697" "29" "4" "5" "4" "145" "15.8" "7.03" "17.15" "4" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "104983812; 109569915; 109569938; 511735" "ENSBIXG00000000751; ENSBTAG00000038748" "LOC104983812; LOC109569915; LOC113905586" "A0A4W2CHH0; A0A6P3GXP4; A0A6P5D2L1; bbis:104983812; biu:109569915; biu:109569938; bta:511735; P02081; Q3SX09" "" "" "0" "0" "0.866" "0.899" "0.878" "0.871" "0.889" "0.954" "0.883" "0.848" "0.649" "252.8" "219.0" "227.3" "222.0" "220.3" "224.7" "241.1" "223.2" "214.3" "164.1" "" "" "" "" "" "" "" "" "" "" "224.2" "181.4" "198.4" "166.0" "183.7" "206.4" "203.8" "184.5" "196.6" "164.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513337833647549896" "False" "High" "IsMasterProtein" "P11717" "Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3" "0.000" "False" "14.695" "1" "3" "5" "3" "2491" "274.2" "5.94" "13.35" "3" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00040, Pf00878" "3482" "ENSG00000197081" "IGF2R" "hsa:3482; P11717; Q7Z7G9; Q96PT5" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "TROP2 regulatory signaling" "6" "0" "1.090" "1.079" "1.064" "1.044" "0.906" "0.959" "0.971" "0.961" "0.700" "118.4" "129.0" "127.8" "125.9" "123.6" "107.3" "113.5" "115.0" "113.8" "82.9" "" "" "" "" "" "" "" "" "" "" "105.0" "106.9" "111.5" "94.2" "103.1" "98.5" "95.9" "95.0" "104.3" "82.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3953931010856732739" "False" "High" "IsMasterProtein" "P16104" "Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2" "0.000" "False" "14.692" "22" "4" "10" "1" "143" "15.1" "10.74" "28.47" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3014" "ENSG00000188486" "H2AX" "hsa:3014; P16104; Q4ZGJ7; Q6IAS5" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Amyloid fiber formation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; RMTs methylate histone arginines; Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response" "47" "3" "0.951" "0.876" "0.923" "0.934" "0.908" "0.848" "0.865" "0.864" "0.587" "576.3" "547.8" "505.0" "532.0" "538.3" "523.4" "488.8" "498.5" "497.7" "338.4" "" "" "" "" "" "" "" "" "" "" "511.0" "453.7" "440.7" "397.8" "448.8" "480.8" "413.2" "412.0" "456.4" "338.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5324652532582305658" "False" "High" "IsMasterProtein" "P53779" "Mitogen-activated protein kinase 10 OS=Homo sapiens OX=9606 GN=MAPK10 PE=1 SV=2" "0.000" "False" "14.670" "10" "5" "6" "1" "464" "52.6" "6.79" "13.92" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5602" "ENSG00000109339" "MAPK10" "A6NFS3; A6NG28; B3KQ94; hsa:5602; P53779; Q15707; Q49AP1" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Focal adhesion; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Wnt signaling pathway and pluripotency; Oxidative stress response; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; G13 signaling pathway; 5q35 copy number variation; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "36" "0" "1.111" "0.890" "1.223" "1.078" "1.025" "1.204" "1.100" "1.073" "1.711" "97.5" "108.3" "86.8" "119.2" "105.1" "99.9" "117.3" "107.3" "104.6" "166.8" "" "" "" "" "" "" "" "" "" "" "86.4" "89.7" "75.7" "89.1" "87.6" "91.8" "99.2" "88.7" "95.9" "166.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1999120718507000118" "False" "High" "IsMasterProtein" "P17707" "S-adenosylmethionine decarboxylase proenzyme OS=Homo sapiens OX=9606 GN=AMD1 PE=1 SV=2" "0.000" "False" "14.656" "9" "3" "3" "3" "334" "38.3" "6.00" "11.77" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf01536" "262" "ENSG00000123505" "AMD1" "E1P5F7; hsa:262; P17707; Q5VXN4; Q5VXN6; Q9BWK4" "Metabolism of polyamines" "Methionine de novo and salvage pathway" "2" "0" "0.974" "0.942" "1.028" "0.942" "1.023" "0.632" "0.571" "0.575" "0.767" "457.5" "445.5" "431.0" "470.5" "431.1" "467.8" "289.2" "261.4" "263.1" "350.9" "" "" "" "" "" "" "" "" "" "" "405.7" "369.0" "376.0" "351.9" "359.5" "429.8" "244.4" "216.0" "241.3" "350.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858291838725637521" "False" "High" "IsMasterProtein" "Q14353" "Guanidinoacetate N-methyltransferase OS=Homo sapiens OX=9606 GN=GAMT PE=1 SV=1" "0.000" "False" "14.653" "9" "1" "3" "1" "236" "26.3" "6.14" "14.44" "1" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "" "2593" "ENSG00000130005" "GAMT" "A8K0A0; hsa:2593; Q14353; Q53Y34; Q8WVJ1" "Transcriptional Regulation by MECP2; Creatine metabolism" "MECP2 and associated Rett syndrome; Creatine pathway" "4" "0" "0.998" "1.006" "1.125" "1.088" "0.910" "1.148" "0.988" "0.936" "1.212" "129.6" "129.4" "130.4" "145.8" "141.0" "118.0" "148.8" "128.1" "121.3" "157.1" "" "" "" "" "" "" "" "" "" "" "115.0" "107.2" "113.8" "109.1" "117.6" "108.4" "125.8" "105.9" "111.3" "157.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7983353042055504763" "False" "High" "IsMasterProtein" "Q6SZW1" "NAD(+) hydrolase SARM1 OS=Homo sapiens OX=9606 GN=SARM1 PE=1 SV=1" "0.000" "False" "14.642" "4" "3" "4" "3" "724" "79.3" "6.55" "10.66" "3" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf07647, Pf13676" "23098" "ENSG00000004139" "SARM1" "hsa:23098; O60277; Q6SZW1; Q7LGG3; Q9NXY5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3536014580655726636" "False" "High" "IsMasterProtein" "P98170" "E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2" "0.000" "False" "14.632" "7" "3" "3" "3" "497" "56.6" "6.65" "12.30" "3" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00653, Pf13920, Pf21290" "331" "ENSG00000101966" "XIAP" "D3DTF2; hsa:331; P98170; Q9NQ14" "TNFR1-induced NF-kappa-B signaling pathway; Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; Regulation of PTEN localization" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity" "20" "0" "1.059" "1.032" "1.016" "1.017" "1.160" "1.033" "0.961" "1.018" "1.567" "483.5" "512.0" "498.8" "491.0" "491.9" "560.9" "499.5" "464.9" "492.2" "757.5" "" "" "" "" "" "" "" "" "" "" "428.8" "424.1" "435.2" "367.2" "410.2" "515.2" "422.2" "384.2" "451.4" "757.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "High" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.000" "False" "14.631" "7" "4" "5" "4" "564" "62.3" "6.99" "14.70" "4" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Coenzyme A biosynthesis" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "2" "0" "1.221" "1.117" "1.386" "1.222" "1.188" "1.183" "0.404" "1.023" "16.245" "34.9" "42.6" "39.0" "48.3" "42.6" "41.4" "41.2" "14.1" "35.7" "566.4" "" "" "" "" "" "" "" "" "" "" "30.9" "35.3" "34.0" "36.2" "35.5" "38.1" "34.9" "11.6" "32.7" "566.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5573084200900719321" "False" "High" "IsMasterProtein" "Q9Y5V0" "Zinc finger protein 706 OS=Homo sapiens OX=9606 GN=ZNF706 PE=1 SV=1" "0.000" "False" "14.598" "47" "4" "10" "4" "76" "8.5" "10.01" "29.16" "4" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf04419, Pf12874" "51123" "ENSG00000120963" "ZNF706" "A8K362; hsa:51123; Q9Y5V0" "Generic Transcription Pathway" "" "1" "0" "0.938" "0.936" "0.922" "0.904" "0.914" "0.838" "0.906" "0.864" "0.519" "2169.6" "2035.2" "2030.9" "1999.7" "1960.8" "1983.4" "1817.6" "1965.6" "1873.5" "1127.1" "" "" "" "" "" "" "" "" "" "" "1923.9" "1685.8" "1772.1" "1495.5" "1635.0" "1821.9" "1536.2" "1624.7" "1718.3" "1127.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6155932716542002822" "False" "High" "IsMasterProtein" "P06239" "Tyrosine-protein kinase Lck OS=Homo sapiens OX=9606 GN=LCK PE=1 SV=6" "0.000" "False" "14.583" "7" "3" "3" "1" "509" "58.0" "5.36" "10.36" "3" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "3932" "ENSG00000182866" "LCK" "D3DPP8; hsa:3932; P06239; P07100; Q12850; Q13152; Q5TDH8; Q5TDH9; Q7RTZ3; Q96DW4; Q9NYT8" "RHOH GTPase cycle; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; DAP12 signaling; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; CD28 dependent Vav1 pathway; Nef Mediated CD4 Down-regulation; Interleukin-2 signaling; Nef and signal transduction; PECAM1 interactions; CTLA4 inhibitory signaling; FLT3 signaling through SRC family kinases" "Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Inflammatory response pathway; Cancer immunotherapy by PD-1 blockade; IL-18 signaling pathway; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; TAR syndrome; Interferon type I signaling pathways; Notch signaling pathway; T-cell receptor signaling pathway" "40" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.000" "False" "14.574" "11" "5" "5" "5" "418" "45.4" "7.99" "12.81" "5" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "1.050" "1.199" "0.994" "1.080" "1.052" "1.094" "1.075" "1.397" "1.337" "86.5" "90.9" "103.8" "86.0" "93.4" "91.0" "94.7" "93.0" "120.8" "115.7" "" "" "" "" "" "" "" "" "" "" "76.7" "75.3" "90.5" "64.3" "77.9" "83.6" "80.0" "76.9" "110.8" "115.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "14.571" "4" "4" "4" "4" "957" "108.7" "7.56" "13.55" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.932" "0.973" "0.906" "0.956" "1.015" "0.968" "0.926" "0.969" "1.188" "538.7" "501.8" "524.0" "488.2" "515.1" "546.6" "521.3" "498.7" "521.8" "639.9" "" "" "" "" "" "" "" "" "" "" "477.7" "415.7" "457.2" "365.1" "429.5" "502.1" "440.6" "412.2" "478.5" "639.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "859606760973151215" "False" "High" "IsMasterProtein" "Q562F6" "Shugoshin 2 OS=Homo sapiens OX=9606 GN=SGO2 PE=1 SV=2" "0.000" "False" "14.554" "4" "6" "7" "6" "1265" "144.7" "7.91" "20.76" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "" "151246" "ENSG00000163535" "SGO2" "hsa:151246; Q53RR9; Q53T20; Q562F6; Q86XY4; Q8IWK2; Q8IZK1; Q8N1Q5; Q96LQ3" "Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cohesin complex - Cornelia de Lange syndrome" "7" "0" "0.974" "0.902" "0.934" "0.892" "0.865" "0.960" "0.977" "0.972" "1.299" "587.0" "571.6" "529.6" "548.5" "523.5" "507.5" "563.3" "573.8" "570.6" "762.8" "" "" "" "" "" "" "" "" "" "" "520.6" "473.5" "462.1" "410.2" "436.5" "466.2" "476.0" "474.3" "523.3" "762.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4828769571271312822" "False" "High" "IsMasterProtein" "P46108" "Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2" "0.000" "False" "14.525" "15" "4" "4" "4" "304" "33.8" "5.55" "12.89" "4" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00017, Pf00018, Pf07653" "1398" "ENSG00000167193" "CRK" "A8MWE8; B0LPE8; D3DTH6; hsa:1398; P46108; Q96GA9; Q96HJ0" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; GDNF signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "31" "0" "1.105" "1.058" "0.980" "1.117" "1.079" "1.098" "1.049" "1.104" "2.687" "325.6" "359.8" "344.5" "319.2" "363.7" "351.4" "357.6" "341.6" "359.5" "875.0" "" "" "" "" "" "" "" "" "" "" "288.7" "298.1" "300.6" "238.7" "303.2" "322.8" "302.2" "282.4" "329.7" "875.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-27127465578060112" "False" "High" "IsMasterProtein" "Q96SU4" "Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2" "0.000" "False" "14.525" "4" "3" "3" "3" "736" "83.1" "6.18" "11.41" "3" "other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114883" "ENSG00000117859" "OSBPL9" "B1AKJ8; B3KPQ4; D3DQ31; hsa:114883; Q5TFC0; Q6IA67; Q86YQ3; Q8NB17; Q8TAS8; Q96SK4; Q96SU4; Q9H9X2" "Synthesis of bile acids and bile salts" "" "1" "0" "0.984" "0.823" "1.099" "1.053" "0.752" "1.058" "0.347" "0.943" "11.942" "149.9" "147.5" "123.4" "164.8" "157.8" "112.7" "158.6" "52.0" "141.3" "1790.0" "" "" "" "" "" "" "" "" "" "" "132.9" "122.2" "107.6" "123.2" "131.6" "103.5" "134.1" "43.0" "129.6" "1790.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2196461866191852716" "False" "High" "IsMasterProtein" "Q9Y5J1" "U3 small nucleolar RNA-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=UTP18 PE=1 SV=3" "0.000" "False" "14.479" "6" "2" "3" "2" "556" "62.0" "8.76" "17.20" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "51096" "ENSG00000011260" "UTP18" "hsa:51096; Q9H4N6; Q9Y5J1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.915" "0.973" "0.891" "0.946" "0.946" "0.802" "0.781" "0.826" "0.386" "201.6" "184.5" "196.1" "179.7" "190.7" "190.8" "161.8" "157.5" "166.6" "77.8" "" "" "" "" "" "" "" "" "" "" "178.8" "152.8" "171.1" "134.4" "159.0" "175.3" "136.7" "130.1" "152.8" "77.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "High" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.000" "False" "14.425" "20" "4" "6" "4" "167" "19.5" "4.74" "21.65" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "" "Breast cancer pathway" "1" "0" "0.983" "0.865" "0.856" "0.800" "0.918" "0.794" "0.806" "0.866" "0.957" "916.4" "900.5" "792.4" "784.7" "733.0" "841.3" "727.8" "738.7" "793.8" "877.0" "" "" "" "" "" "" "" "" "" "" "812.6" "745.9" "691.4" "586.9" "611.3" "772.8" "615.1" "610.6" "728.0" "877.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8284852689861497980" "False" "High" "IsMasterProtein" "Q5VV52" "Zinc finger protein 691 OS=Homo sapiens OX=9606 GN=ZNF691 PE=1 SV=2" "0.000" "False" "14.410" "10" "2" "4" "2" "315" "35.8" "7.80" "16.44" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465" "51058" "ENSG00000164011" "ZNF691" "A8MXP6; B4DJR7; hsa:51058; O95878; Q5VV52; Q9NWE8" "Generic Transcription Pathway" "" "1" "0" "0.938" "0.802" "0.903" "0.847" "0.935" "0.856" "1.144" "0.924" "0.682" "65.0" "61.0" "52.1" "58.7" "55.0" "60.8" "55.6" "74.3" "60.1" "44.3" "" "" "" "" "" "" "" "" "" "" "57.6" "50.5" "45.5" "43.9" "45.9" "55.9" "47.0" "61.4" "55.1" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004295546409196846" "False" "High" "IsMasterProtein" "P13747" "HLA class I histocompatibility antigen, alpha chain E OS=Homo sapiens OX=9606 GN=HLA-E PE=1 SV=4" "0.000" "False" "14.410" "7" "2" "3" "1" "358" "40.0" "5.83" "11.49" "2" "stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3133" "ENSG00000204592; ENSG00000206493; ENSG00000225201; ENSG00000229252; ENSG00000230254; ENSG00000233904; ENSG00000236632" "HLA-E" "E2G051; hsa:3133; P13747; Q30169; Q6DU44; Q9BT83; Q9GIY7; Q9GIY8" "ER-Phagosome pathway; Interferon gamma signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144980634344963458" "False" "High" "IsMasterProtein" "O14686" "Histone-lysine N-methyltransferase 2D OS=Homo sapiens OX=9606 GN=KMT2D PE=1 SV=2" "0.000" "False" "14.362" "1" "4" "4" "4" "5537" "593.0" "5.58" "12.88" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "8085" "ENSG00000167548" "KMT2D" "hsa:8085; O14686; O14687" "Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Histone modifications; 16p11.2 proximal deletion syndrome" "8" "0" "1.054" "0.853" "1.083" "0.924" "0.966" "0.850" "0.896" "0.949" "1.157" "112.7" "118.8" "96.1" "122.1" "104.1" "108.9" "95.8" "101.0" "107.0" "130.4" "" "" "" "" "" "" "" "" "" "" "99.9" "98.4" "83.8" "91.3" "86.8" "100.0" "81.0" "83.5" "98.1" "130.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "14.357" "15" "5" "6" "5" "312" "35.1" "9.13" "15.62" "5" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "0.939" "0.933" "0.957" "0.942" "0.838" "0.896" "0.774" "0.942" "3.928" "439.2" "412.3" "409.7" "420.1" "413.7" "367.9" "393.6" "339.9" "413.8" "1725.1" "" "" "" "" "" "" "" "" "" "" "389.4" "341.5" "357.5" "314.2" "345.0" "338.0" "332.7" "281.0" "379.5" "1725.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3452513591771994158" "False" "High" "IsMasterProtein" "Q6ICG6" "Uncharacterized protein KIAA0930 OS=Homo sapiens OX=9606 GN=KIAA0930 PE=1 SV=1" "0.000" "False" "14.352" "5" "2" "2" "2" "404" "45.8" "7.94" "8.16" "2" "" "" "" "Pf09741" "23313" "ENSG00000100364" "KIAA0930" "B0QY17; B0QY19; B3KT48; hsa:23313; Q6ICG6; Q6ZVE5; Q7Z6K9; Q8IZ76; Q9Y2E2" "" "" "0" "0" "0.901" "0.614" "0.931" "0.905" "0.575" "0.852" "0.683" "0.965" "0.636" "52.1" "47.0" "32.0" "48.5" "47.2" "30.0" "44.4" "35.6" "50.3" "33.2" "" "" "" "" "" "" "" "" "" "" "46.2" "38.9" "27.9" "36.3" "39.3" "27.5" "37.5" "29.4" "46.1" "33.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023891521044108187" "False" "High" "IsMasterProtein" "Q96BX8" "MOB kinase activator 3A OS=Homo sapiens OX=9606 GN=MOB3A PE=1 SV=1" "0.000" "False" "14.339" "18" "4" "5" "4" "217" "25.4" "8.63" "17.62" "4" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "126308" "ENSG00000172081" "MOB3A" "B3KTF1; hsa:126308; O75249; Q8TF69; Q96BX8" "" "" "0" "0" "1.013" "1.104" "1.077" "1.058" "0.965" "0.755" "0.621" "0.726" "4.268" "344.5" "348.9" "380.4" "371.0" "364.4" "332.5" "260.0" "213.9" "250.0" "1470.2" "" "" "" "" "" "" "" "" "" "" "305.5" "289.0" "331.9" "277.5" "303.9" "305.4" "219.7" "176.8" "229.2" "1470.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9164959202025983104" "False" "High" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "0.000" "False" "14.332" "7" "5" "5" "5" "902" "102.5" "6.84" "13.73" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "0.977" "0.854" "1.123" "1.082" "0.993" "1.071" "0.939" "1.054" "1.187" "71.0" "69.4" "60.6" "79.7" "76.8" "70.5" "76.1" "66.7" "74.8" "84.3" "" "" "" "" "" "" "" "" "" "" "62.9" "57.5" "52.9" "59.6" "64.0" "64.8" "64.3" "55.1" "68.6" "84.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6176732133664384368" "False" "High" "IsMasterProtein" "Q70CQ2" "Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2" "0.000" "False" "14.320" "1" "5" "6" "5" "3546" "404.0" "5.82" "13.61" "5" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf12030" "9736" "ENSG00000115464" "USP34" "A8MWD0; B3KWU9; hsa:9736; O60316; O94834; Q3B777; Q6P6C9; Q70CQ2; Q7L8P6; Q8N3T9; Q8TBW2; Q9UGA1" "Ub-specific processing proteases; TCF dependent signaling in response to WNT" "" "2" "0" "1.020" "0.935" "1.026" "0.940" "1.035" "1.067" "0.836" "0.984" "3.984" "464.0" "473.5" "433.7" "475.9" "436.1" "480.2" "495.2" "387.9" "456.4" "1848.8" "" "" "" "" "" "" "" "" "" "" "411.5" "392.2" "378.4" "355.9" "363.6" "441.1" "418.5" "320.7" "418.6" "1848.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.000" "False" "14.315" "23" "2" "3" "2" "120" "12.9" "6.67" "10.86" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "" "Translation factors; Fragile X syndrome" "2" "0" "0.940" "0.942" "1.091" "0.905" "1.211" "1.128" "1.044" "1.002" "0.505" "155.2" "145.8" "146.2" "169.3" "140.5" "187.9" "175.1" "162.0" "155.5" "78.4" "" "" "" "" "" "" "" "" "" "" "137.6" "120.8" "127.6" "126.6" "117.2" "172.6" "148.0" "133.9" "142.6" "78.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-932703795777546839" "False" "High" "IsMasterProtein" "Q96BJ3" "Axin interactor, dorsalization-associated protein OS=Homo sapiens OX=9606 GN=AIDA PE=1 SV=1" "0.000" "False" "14.301" "10" "2" "2" "2" "306" "35.0" "6.55" "10.75" "2" "developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf08910, Pf14186" "64853" "ENSG00000186063" "AIDA" "A8K1F0; hsa:64853; Q49A81; Q5JRA4; Q658P1; Q96BJ3; Q9H9E8" "" "" "0" "0" "0.983" "0.997" "0.956" "1.019" "0.959" "0.961" "0.982" "1.011" "1.159" "265.0" "260.4" "264.3" "253.4" "270.2" "254.2" "254.7" "260.2" "267.9" "307.3" "" "" "" "" "" "" "" "" "" "" "235.0" "215.7" "230.6" "189.5" "225.3" "233.6" "215.3" "215.1" "245.7" "307.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5924667286913212153" "False" "High" "IsMasterProtein" "Q9Y484" "WD repeat domain phosphoinositide-interacting protein 4 OS=Homo sapiens OX=9606 GN=WDR45 PE=1 SV=1" "0.000" "False" "14.285" "11" "4" "4" "4" "360" "39.8" "7.14" "14.21" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf21032" "11152" "ENSG00000196998; ENSG00000292221" "WDR45" "A6NGH5; B7WPI2; hsa:11152; Q5MNZ5; Q6IBS7; Q6NT94; Q96H03; Q9Y484" "Macroautophagy" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; ADHD and autism (ASD) linked metabolic pathways and SNP" "3" "0" "1.092" "1.015" "1.027" "1.058" "0.985" "1.072" "1.133" "1.000" "0.876" "271.5" "296.5" "275.7" "278.9" "287.3" "267.5" "291.1" "307.6" "271.6" "237.8" "" "" "" "" "" "" "" "" "" "" "240.8" "245.6" "240.5" "208.6" "239.6" "245.7" "246.0" "254.3" "249.1" "237.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7227303497452228744" "False" "High" "IsMasterProtein" "Q9P0S2" "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COX16 PE=1 SV=1" "0.000" "False" "14.276" "22" "2" "6" "2" "106" "12.3" "9.50" "22.67" "2" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14138" "51241" "ENSG00000133983" "COX16" "A6NDT5; A8K3X8; B8XYC5; hsa:51241; Q9P0S2" "Cytoprotection by HMOX1; TP53 Regulates Metabolic Genes; Respiratory electron transport" "Mitochondrial complex IV assembly" "4" "0" "1.054" "1.037" "0.996" "1.012" "1.047" "0.968" "1.132" "1.050" "0.305" "819.5" "863.5" "849.9" "815.9" "829.7" "857.6" "793.2" "927.3" "860.2" "250.0" "" "" "" "" "" "" "" "" "" "" "726.7" "715.3" "741.5" "610.2" "691.8" "787.8" "670.4" "766.5" "789.0" "250.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8113893803591480288" "False" "High" "IsMasterProtein" "Cont_Q7Z794" "Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3" "0.000" "True" "14.260" "7" "4" "4" "1" "578" "61.9" "5.99" "15.47" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "374454" "ENSG00000189182" "KRT77" "hsa:374454; Q7RTS8; Q7Z794" "Formation of the cornified envelope" "" "2" "0" "0.898" "0.839" "1.219" "0.944" "0.994" "0.966" "1.002" "0.925" "0.707" "105.9" "95.1" "88.8" "129.0" "99.9" "105.2" "102.3" "106.1" "97.9" "74.9" "" "" "" "" "" "" "" "" "" "" "93.9" "78.8" "77.5" "96.5" "83.3" "96.7" "86.4" "87.7" "89.8" "74.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1241863298076822509" "False" "High" "IsMasterProtein" "Q5VUA4" "Zinc finger protein 318 OS=Homo sapiens OX=9606 GN=ZNF318 PE=1 SV=2" "0.000" "False" "14.231" "2" "5" "5" "5" "2279" "251.0" "7.20" "16.59" "5" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "24149" "ENSG00000171467" "ZNF318" "hsa:24149; O94796; Q4G0E4; Q5VUA4; Q8NEM6; Q9UNU8; Q9Y2W9" "" "Androgen receptor signaling pathway" "1" "0" "0.991" "0.900" "0.979" "0.928" "0.987" "0.948" "0.967" "0.897" "1.102" "670.6" "664.4" "603.8" "656.3" "622.1" "662.1" "635.5" "648.5" "601.2" "738.9" "" "" "" "" "" "" "" "" "" "" "594.6" "550.3" "526.8" "490.8" "518.7" "608.2" "537.1" "536.0" "551.4" "738.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6297313033402222307" "False" "High" "IsMasterProtein" "Q8TF01" "Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2" "0.000" "False" "14.201" "3" "3" "3" "3" "805" "92.5" "10.02" "9.18" "3" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15996" "25957" "ENSG00000132424" "PNISR" "A8K540; E1P5D2; hsa:25957; Q5T064; Q5T065; Q6P2B4; Q6P2N4; Q6PJ93; Q6PK36; Q7Z640; Q8N2L1; Q8TF00; Q8TF01; Q96K10; Q96SI3; Q96SM5; Q9P076; Q9P0C0; Q9Y4N3" "" "" "0" "0" "1.005" "0.878" "0.975" "1.044" "0.930" "1.072" "1.091" "1.024" "0.404" "225.4" "226.6" "198.0" "219.9" "235.4" "209.6" "241.5" "245.8" "230.8" "91.0" "" "" "" "" "" "" "" "" "" "" "199.9" "187.7" "172.7" "164.4" "196.3" "192.5" "204.1" "203.2" "211.7" "91.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "14.201" "13" "3" "4" "3" "248" "29.2" "10.65" "12.92" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "1.234" "0.996" "1.401" "1.315" "1.088" "1.167" "1.161" "1.050" "0.847" "218.3" "269.4" "217.4" "305.9" "287.0" "237.5" "254.9" "253.4" "229.3" "184.9" "" "" "" "" "" "" "" "" "" "" "193.6" "223.1" "189.7" "228.7" "239.3" "218.2" "215.4" "209.5" "210.3" "184.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8960608706317852180" "False" "High" "IsMasterProtein" "A1L188" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 OS=Homo sapiens OX=9606 GN=NDUFAF8 PE=1 SV=1" "0.000" "False" "14.199" "32" "2" "4" "2" "74" "7.8" "9.32" "16.36" "2" "cell organization and biogenesis" "mitochondrion" "" "" "284184" "ENSG00000224877" "NDUFAF8" "A1L188; hsa:284184" "" "" "0" "0" "1.038" "0.962" "1.135" "0.970" "0.848" "1.154" "0.931" "1.083" "0.670" "655.6" "680.3" "630.6" "744.3" "635.7" "556.0" "756.6" "610.7" "709.9" "439.4" "" "" "" "" "" "" "" "" "" "" "581.4" "563.5" "550.2" "556.6" "530.1" "510.7" "639.4" "504.8" "651.0" "439.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8098039391314381890" "False" "High" "IsMasterProtein" "Q92503" "SEC14-like protein 1 OS=Homo sapiens OX=9606 GN=SEC14L1 PE=1 SV=2" "0.000" "False" "14.172" "7" "4" "4" "4" "715" "81.2" "6.43" "9.87" "4" "stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00650, Pf03765, Pf04707" "6397" "ENSG00000129657" "SEC14L1" "A8K4E8; B4DDI5; D5G3K1; hsa:6397; Q92503; Q99780" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "2" "0" "0.968" "0.909" "1.073" "0.958" "0.947" "0.965" "0.995" "0.898" "2.429" "163.2" "158.0" "148.3" "175.1" "156.3" "154.5" "157.4" "162.4" "146.5" "396.3" "" "" "" "" "" "" "" "" "" "" "144.7" "130.9" "129.4" "130.9" "130.4" "141.9" "133.0" "134.2" "134.3" "396.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643865994575879356" "False" "High" "IsMasterProtein" "Q7Z6M4" "Transcription termination factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF4 PE=1 SV=3" "0.000" "False" "14.171" "3" "1" "2" "1" "381" "43.9" "4.82" "8.16" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf02536" "130916" "ENSG00000122085" "MTERF4" "A8K6K0; hsa:130916; Q7Z6M4; Q9P0E0" "rRNA modification in the mitochondrion" "CCL18 signaling pathway; 2q37 copy number variation syndrome" "3" "0" "0.916" "0.761" "0.969" "0.823" "1.013" "0.846" "0.931" "0.982" "1.592" "59.2" "54.3" "45.1" "57.4" "48.8" "60.0" "50.1" "55.1" "58.1" "94.3" "" "" "" "" "" "" "" "" "" "" "52.5" "44.9" "39.3" "42.9" "40.7" "55.1" "42.4" "45.6" "53.3" "94.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2147212707680779052" "False" "High" "IsMasterProtein" "P49427" "Ubiquitin-conjugating enzyme E2 R1 OS=Homo sapiens OX=9606 GN=CDC34 PE=1 SV=2" "0.000" "False" "14.146" "17" "4" "4" "3" "236" "26.7" "4.54" "13.25" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "997" "ENSG00000099804" "CDC34" "A8K689; hsa:997; P49427" "FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Vitamin D receptor pathway" "6" "0" "0.858" "0.840" "1.241" "1.079" "0.836" "1.085" "0.840" "0.892" "4.737" "130.0" "111.6" "109.2" "161.4" "140.3" "108.7" "141.0" "109.2" "115.9" "615.8" "" "" "" "" "" "" "" "" "" "" "115.3" "92.4" "95.3" "120.7" "117.0" "99.9" "119.2" "90.2" "106.3" "615.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2025748717046247647" "False" "High" "IsMasterProtein" "Q8IV63" "Serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2" "0.000" "False" "14.139" "9" "3" "4" "3" "474" "52.8" "9.04" "13.33" "3" "signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13240" "51231" "ENSG00000105053" "VRK3" "A6NEG5; A8KA53; hsa:51231; Q502Y2; Q8IV63; Q9P2V8" "ERKs are inactivated" "" "1" "0" "0.984" "1.078" "1.012" "1.061" "0.994" "1.152" "1.113" "1.109" "1.302" "606.1" "596.2" "653.4" "613.2" "643.2" "602.2" "698.2" "674.7" "672.5" "789.0" "" "" "" "" "" "" "" "" "" "" "537.5" "493.9" "570.1" "458.6" "536.4" "553.2" "590.1" "557.7" "616.8" "789.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241628752191747033" "False" "High" "IsMasterProtein" "Q9Y6W3" "Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1" "0.000" "False" "14.117" "5" "4" "4" "4" "813" "92.6" "7.65" "8.38" "4" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00648, Pf01067, Pf04212" "23473" "ENSG00000131375" "CAPN7" "hsa:23473; Q9Y6W3" "Degradation of the extracellular matrix" "Integrin-mediated cell adhesion" "2" "0" "1.168" "1.110" "1.164" "1.019" "1.056" "1.139" "0.945" "1.135" "3.797" "185.3" "216.4" "205.5" "215.7" "188.8" "195.5" "211.0" "175.1" "210.2" "703.3" "" "" "" "" "" "" "" "" "" "" "164.3" "179.3" "179.3" "161.3" "157.4" "179.6" "178.3" "144.7" "192.8" "703.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.000" "False" "14.115" "53" "3" "4" "3" "73" "8.5" "8.44" "14.71" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "mRNA Splicing - Major Pathway" "" "1" "0" "0.932" "0.811" "0.892" "0.773" "0.857" "0.812" "0.860" "0.698" "1.720" "80.1" "74.7" "64.9" "71.4" "61.9" "68.6" "65.0" "68.9" "55.9" "137.8" "" "" "" "" "" "" "" "" "" "" "71.0" "61.8" "56.7" "53.4" "51.6" "63.1" "55.0" "56.9" "51.2" "137.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945964816553277045" "False" "High" "IsMasterProtein" "Q9Y2X0" "Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2" "0.000" "False" "14.083" "4" "4" "4" "4" "877" "96.7" "7.37" "13.52" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00400, Pf11635, Pf20718, Pf20719" "10025" "ENSG00000175221" "MED16" "hsa:10025; Q6PJT2; Q96AD4; Q96I35; Q9Y2X0; Q9Y652" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.001" "0.984" "1.046" "1.042" "0.976" "0.950" "0.927" "0.951" "1.096" "568.2" "568.9" "558.8" "594.3" "591.9" "554.3" "539.7" "526.6" "540.6" "622.7" "" "" "" "" "" "" "" "" "" "" "503.8" "471.3" "487.6" "444.5" "493.6" "509.1" "456.1" "435.2" "495.8" "622.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3275196182656961977" "False" "High" "IsMasterProtein" "Q8WXB1" "Protein N-lysine methyltransferase METTL21A OS=Homo sapiens OX=9606 GN=METTL21A PE=1 SV=2" "0.000" "False" "14.077" "17" "4" "5" "4" "218" "24.6" "6.27" "14.93" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10294" "151194" "ENSG00000144401" "METTL21A" "hsa:151194; Q53RV0; Q8N1Z9; Q8WXB1; Q96GH6" "Protein methylation" "" "1" "0" "1.033" "1.041" "1.000" "1.060" "1.110" "0.973" "1.058" "0.942" "0.481" "344.6" "355.9" "358.6" "344.7" "365.2" "382.5" "335.4" "364.7" "324.6" "165.7" "" "" "" "" "" "" "" "" "" "" "305.6" "294.8" "312.9" "257.8" "304.6" "351.4" "283.4" "301.4" "297.7" "165.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8081850607027736323" "False" "High" "IsMasterProtein" "Q9P0J1" "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDP1 PE=1 SV=3" "0.000" "False" "14.077" "6" "3" "3" "3" "537" "61.0" "6.67" "11.39" "3" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "54704" "ENSG00000164951" "PDP1" "B3KX71; hsa:54704; J3KPU0; Q5U5K1; Q9P0J1" "Regulation of pyruvate dehydrogenase (PDH) complex" "Orexin receptor pathway; Glucose metabolism in triple-negative breast cancer cells" "3" "0" "0.725" "0.733" "0.768" "0.775" "0.690" "0.878" "0.775" "0.746" "0.848" "275.0" "199.3" "201.6" "211.2" "213.1" "189.8" "241.5" "213.1" "205.1" "233.3" "" "" "" "" "" "" "" "" "" "" "243.8" "165.1" "175.9" "157.9" "177.7" "174.3" "204.1" "176.1" "188.1" "233.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4002358354751571135" "False" "High" "IsMasterProtein" "Q8NFP9" "Neurobeachin OS=Homo sapiens OX=9606 GN=NBEA PE=1 SV=3" "0.000" "False" "14.058" "2" "5" "5" "3" "2946" "327.6" "6.18" "14.21" "5" "other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "26960" "ENSG00000172915" "NBEA" "B7Z2H9; hsa:26960; Q5T320; Q8NFP9; Q9HCM8; Q9NSU1; Q9NW98; Q9Y6J1" "NOTCH1 Intracellular Domain Regulates Transcription; PKA activation; Neurotransmitter receptors and postsynaptic signal transmission; Assembly and cell surface presentation of NMDA receptors" "" "4" "0" "0.881" "0.862" "0.952" "0.882" "0.787" "0.795" "0.801" "0.831" "0.598" "177.3" "156.2" "152.8" "168.8" "156.3" "139.5" "140.9" "141.9" "147.4" "106.0" "" "" "" "" "" "" "" "" "" "" "157.2" "129.4" "133.3" "126.2" "130.3" "128.1" "119.1" "117.3" "135.2" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4722809731006219467" "False" "High" "IsMasterProtein" "P48047" "ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1" "0.000" "False" "14.050" "15" "2" "2" "2" "213" "23.3" "9.96" "11.30" "2" "other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion" "transporter activity" "Pf00213" "539" "ENSG00000241837" "ATP5PO" "B2R4E2; hsa:539; P48047; Q5U042; Q6IBI2" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "6" "0" "1.230" "1.073" "1.146" "1.292" "1.200" "1.148" "0.978" "1.328" "1.431" "134.0" "164.8" "143.7" "153.6" "173.1" "160.7" "153.8" "131.1" "177.9" "191.8" "" "" "" "" "" "" "" "" "" "" "118.8" "136.5" "125.4" "114.9" "144.4" "147.7" "130.0" "108.4" "163.2" "191.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2950951748836187489" "False" "High" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "0.000" "False" "14.046" "17" "4" "4" "4" "304" "34.3" "9.28" "13.66" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "SUMOylation of DNA damage response and repair proteins" "15q11q13 copy number variation" "2" "0" "0.928" "0.840" "0.933" "0.824" "0.772" "0.856" "0.874" "0.994" "1.222" "367.4" "341.1" "308.5" "342.6" "302.6" "283.6" "314.3" "321.1" "365.3" "448.9" "" "" "" "" "" "" "" "" "" "" "325.8" "282.6" "269.2" "256.3" "252.3" "260.5" "265.7" "265.4" "335.1" "448.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8914227060072634545" "False" "High" "IsMasterProtein" "O96009" "Napsin-A OS=Homo sapiens OX=9606 GN=NAPSA PE=1 SV=1" "0.000" "False" "14.035" "10" "3" "4" "3" "420" "45.4" "6.61" "12.45" "3" "protein metabolism;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026" "9476" "ENSG00000131400" "NAPSA" "hsa:9476; O96009; Q8WWD9" "Surfactant metabolism" "" "1" "0" "1.184" "0.914" "1.238" "0.777" "1.241" "1.534" "1.054" "0.954" "0.680" "26.6" "31.6" "24.4" "33.0" "20.7" "33.1" "40.9" "28.1" "25.4" "18.1" "" "" "" "" "" "" "" "" "" "" "23.6" "26.1" "21.3" "24.7" "17.3" "30.4" "34.5" "23.2" "23.3" "18.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4567106574901643860" "False" "High" "IsMasterProtein" "O60826" "Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1" "0.000" "False" "14.018" "5" "2" "2" "2" "627" "70.7" "6.74" "9.72" "2" "transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle" "other molecular function" "Pf05667, Pf21674" "28952" "ENSG00000101997" "CCDC22" "A8K7G1; hsa:28952; O60826" "Neddylation" "" "1" "0" "1.324" "1.042" "1.403" "1.392" "1.438" "1.460" "0.961" "1.074" "4.219" "33.9" "44.9" "35.3" "47.6" "47.2" "48.8" "49.5" "32.6" "36.4" "143.1" "" "" "" "" "" "" "" "" "" "" "30.1" "37.2" "30.8" "35.6" "39.4" "44.8" "41.9" "26.9" "33.4" "143.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9196998486354008360" "False" "High" "IsMasterProtein" "Q6F5E8" "Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2" "0.000" "False" "13.995" "2" "3" "4" "3" "1435" "154.6" "6.76" "12.45" "3" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13516, Pf16000, Pf17888" "146206" "ENSG00000159753" "CARMIL2" "B8X2Z3; hsa:146206; Q6F5E8" "" "" "0" "0" "0.918" "0.838" "0.934" "1.038" "0.875" "0.985" "0.881" "1.009" "2.629" "134.5" "123.5" "112.7" "125.6" "139.6" "117.7" "132.5" "118.5" "135.7" "353.6" "" "" "" "" "" "" "" "" "" "" "119.3" "102.3" "98.4" "93.9" "116.4" "108.1" "112.0" "97.9" "124.5" "353.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3092682979585279254" "False" "High" "IsMasterProtein" "Q96BP3" "Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1" "0.000" "False" "13.988" "7" "5" "5" "5" "646" "73.5" "7.15" "12.54" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160, Pf00400" "23398" "ENSG00000113593" "PPWD1" "B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3" "mRNA Splicing - Major Pathway" "" "1" "0" "1.097" "0.950" "1.033" "1.010" "0.951" "0.987" "0.875" "0.931" "2.667" "331.0" "363.1" "314.6" "341.8" "334.4" "314.8" "326.8" "289.6" "308.1" "882.8" "" "" "" "" "" "" "" "" "" "" "293.5" "300.8" "274.5" "255.6" "278.9" "289.2" "276.2" "239.4" "282.6" "882.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1016656761563188351" "False" "High" "IsMasterProtein" "O15127" "Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2" "0.000" "False" "13.982" "12" "4" "4" "4" "329" "36.6" "6.10" "14.92" "4" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04144" "10066" "ENSG00000140497" "SCAMP2" "B2RDF0; hsa:10066; O15127; Q9BQE8" "" "Serotonin transporter activity; Monoamine transport" "2" "0" "0.998" "0.901" "1.457" "1.006" "1.230" "1.135" "1.109" "0.795" "1.068" "41.1" "41.0" "37.1" "60.0" "41.4" "50.6" "46.7" "45.6" "32.7" "43.9" "" "" "" "" "" "" "" "" "" "" "36.5" "34.0" "32.3" "44.8" "34.5" "46.5" "39.5" "37.7" "30.0" "43.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625848183831329232" "False" "High" "IsMasterProtein" "Q6VMQ6" "Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3" "0.000" "False" "13.973" "2" "2" "2" "2" "1270" "136.3" "4.70" "8.16" "2" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf16788, Pf16794" "55729" "ENSG00000171681" "ATF7IP" "F5GX74; G3V1U0; hsa:55729; Q4G0T9; Q6P3T3; Q6VMQ6; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8" "PKMTs methylate histone lysines" "" "1" "0" "1.066" "0.923" "1.065" "1.130" "1.266" "1.109" "0.885" "0.915" "2.755" "46.6" "49.7" "43.0" "49.6" "52.6" "59.0" "51.7" "41.2" "42.6" "128.3" "" "" "" "" "" "" "" "" "" "" "41.3" "41.1" "37.5" "37.1" "43.9" "54.2" "43.7" "34.1" "39.1" "128.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021225223718005983" "False" "High" "IsMasterProtein" "P31949" "Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2" "0.000" "False" "13.970" "39" "4" "7" "4" "105" "11.7" "7.12" "21.72" "4" "signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6282" "ENSG00000163191" "S100A11" "hsa:6282; P31949; Q5VTK0" "Neutrophil degranulation" "" "1" "0" "0.865" "0.918" "0.827" "0.751" "0.875" "0.839" "0.856" "0.838" "0.459" "903.0" "781.0" "829.0" "746.7" "678.5" "789.8" "757.2" "772.8" "757.1" "414.3" "" "" "" "" "" "" "" "" "" "" "800.7" "646.9" "723.3" "558.5" "565.8" "725.6" "640.0" "638.8" "694.4" "414.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-535471645367581150" "False" "High" "IsMasterProtein" "Q9Y3B6" "ER membrane protein complex subunit 9 OS=Homo sapiens OX=9606 GN=EMC9 PE=1 SV=3" "0.000" "False" "13.958" "17" "3" "4" "3" "208" "23.0" "5.91" "13.39" "3" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf03665" "51016" "ENSG00000100908; ENSG00000285377" "EMC9" "D3DS60; hsa:51016; Q9BUM3; Q9Y3B6" "" "" "0" "0" "1.011" "1.067" "1.037" "1.004" "0.884" "0.905" "0.995" "0.930" "1.662" "39.1" "39.5" "41.7" "40.5" "39.2" "34.5" "35.4" "38.8" "36.3" "64.9" "" "" "" "" "" "" "" "" "" "" "34.6" "32.7" "36.4" "30.3" "32.7" "31.7" "29.9" "32.1" "33.3" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "13.954" "19" "3" "3" "3" "172" "20.0" "4.58" "11.79" "3" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "1.001" "1.066" "1.178" "1.182" "1.028" "1.152" "0.481" "0.866" "8.186" "248.4" "248.7" "264.9" "292.7" "293.6" "255.4" "286.3" "119.4" "215.2" "2033.5" "" "" "" "" "" "" "" "" "" "" "220.3" "206.0" "231.1" "218.9" "244.9" "234.6" "241.9" "98.7" "197.4" "2033.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2203431477329866008" "False" "High" "IsMasterProtein" "Q9BZK3" "Putative nascent polypeptide-associated complex subunit alpha-like protein OS=Homo sapiens OX=9606 GN=NACA4P PE=5 SV=1" "0.000" "False" "13.937" "7" "1" "4" "1" "213" "23.3" "4.59" "19.98" "1" "other biological processes" "translational apparatus;other cell component" "other molecular function" "Pf01849" "" "" "NACA4P" "Q9BZK3" "" "" "0" "0" "1.322" "1.102" "1.441" "1.272" "1.104" "1.229" "1.221" "1.188" "0.787" "184.1" "243.3" "202.9" "265.3" "234.1" "203.2" "226.2" "224.7" "218.7" "144.9" "" "" "" "" "" "" "" "" "" "" "163.2" "201.6" "177.0" "198.4" "195.2" "186.7" "191.2" "185.7" "200.5" "144.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664937440056635092" "False" "High" "IsMasterProtein" "Q9BQ48" "Large ribosomal subunit protein bL34m OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1" "0.000" "False" "13.928" "24" "2" "5" "2" "92" "10.2" "12.25" "19.54" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00468" "64981" "ENSG00000130312" "MRPL34" "hsa:64981; Q9BQ48" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.094" "1.126" "1.048" "1.135" "1.158" "0.955" "1.071" "1.049" "0.277" "803.8" "878.9" "905.1" "842.0" "912.2" "931.1" "767.4" "860.6" "842.8" "222.8" "" "" "" "" "" "" "" "" "" "" "712.8" "728.1" "789.8" "629.7" "760.7" "855.3" "648.6" "711.4" "773.0" "222.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643527966773386320" "False" "High" "IsMasterProtein" "Q8IWZ8" "SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2" "0.000" "False" "13.916" "5" "3" "3" "3" "645" "72.4" "7.61" "11.73" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "57794" "ENSG00000105705" "SUGP1" "hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.752" "1.066" "1.300" "1.155" "1.315" "1.134" "1.028" "1.051" "1.559" "306.5" "537.1" "326.8" "398.5" "353.9" "403.0" "347.5" "315.0" "322.2" "477.9" "" "" "" "" "" "" "" "" "" "" "271.8" "444.9" "285.1" "298.0" "295.1" "370.2" "293.7" "260.4" "295.5" "477.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699883784093853229" "False" "High" "IsMasterProtein" "Q8IY47" "Kelch repeat and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KBTBD2 PE=1 SV=2" "0.000" "False" "13.914" "6" "4" "4" "4" "623" "71.3" "5.62" "11.18" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "25948" "ENSG00000170852" "KBTBD2" "A8K9T7; hsa:25948; Q86Y62; Q8IY47; Q9P239; Q9UFM7; Q9Y382" "" "" "0" "0" "1.082" "1.060" "1.031" "1.133" "1.045" "1.091" "1.037" "1.005" "0.528" "368.6" "398.8" "390.9" "380.1" "417.7" "385.0" "402.2" "382.1" "370.6" "194.5" "" "" "" "" "" "" "" "" "" "" "326.9" "330.3" "341.1" "284.2" "348.3" "353.7" "339.9" "315.8" "339.9" "194.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396940342238216990" "False" "High" "IsMasterProtein" "Q9H6Y2" "WD repeat-containing protein 55 OS=Homo sapiens OX=9606 GN=WDR55 PE=1 SV=2" "0.000" "False" "13.906" "7" "2" "3" "2" "383" "42.0" "4.92" "12.32" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf12894" "54853" "ENSG00000120314" "WDR55" "hsa:54853; Q9H6Y2; Q9NXK4" "" "" "0" "0" "1.174" "1.117" "1.230" "1.140" "1.083" "1.217" "1.103" "1.413" "1.068" "183.8" "215.8" "205.3" "226.0" "209.5" "199.0" "223.6" "202.7" "259.7" "196.2" "" "" "" "" "" "" "" "" "" "" "163.0" "178.8" "179.1" "169.0" "174.7" "182.8" "189.0" "167.6" "238.2" "196.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073332157955076013" "False" "High" "IsMasterProtein" "P50914" "Large ribosomal subunit protein eL14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "0.000" "False" "13.879" "14" "3" "6" "3" "215" "23.4" "10.93" "18.82" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.059" "0.988" "1.083" "1.106" "0.955" "0.899" "1.024" "0.993" "0.604" "598.9" "634.2" "591.9" "648.8" "662.4" "572.0" "538.5" "613.4" "594.8" "361.8" "" "" "" "" "" "" "" "" "" "" "531.1" "525.3" "516.5" "485.2" "552.3" "525.4" "455.1" "507.0" "545.5" "361.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9154000995379348407" "False" "High" "IsMasterProtein" "Q16644" "MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1" "0.000" "False" "13.841" "13" "4" "4" "3" "382" "43.0" "7.28" "11.48" "4" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7867" "ENSG00000114738" "MAPKAPK3" "B5BU67; hsa:7867; Q16644" "VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; p38MAPK events; activated TAK1 mediates p38 MAPK activation" "Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Serotonin HTR1 group and FOS pathway" "7" "0" "0.906" "0.997" "1.155" "1.004" "1.034" "0.987" "0.989" "0.849" "2.048" "257.5" "233.4" "256.7" "297.3" "258.6" "266.2" "254.2" "254.8" "218.7" "527.4" "" "" "" "" "" "" "" "" "" "" "228.4" "193.4" "224.0" "222.4" "215.6" "244.5" "214.9" "210.6" "200.5" "527.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.000" "False" "13.837" "5" "3" "3" "3" "729" "78.8" "5.48" "9.04" "3" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "" "Splicing factor NOVA regulated synaptic proteins" "1" "0" "0.926" "1.060" "0.958" "1.063" "1.015" "1.095" "0.860" "1.003" "2.266" "135.8" "125.8" "144.0" "130.1" "144.3" "137.8" "148.6" "116.8" "136.1" "307.8" "" "" "" "" "" "" "" "" "" "" "120.4" "104.2" "125.6" "97.3" "120.4" "126.6" "125.6" "96.6" "124.9" "307.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660276496901993886" "False" "High" "IsMasterProtein" "Q96SY0" "Integrator complex subunit 14 OS=Homo sapiens OX=9606 GN=INTS14 PE=1 SV=2" "0.000" "False" "13.818" "6" "3" "3" "3" "518" "57.4" "5.12" "13.27" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13519, Pf19435, Pf20504" "81556" "ENSG00000138614" "INTS14" "B4DDI6; B4DVD5; hsa:81556; Q49AH8; Q96HX5; Q96SY0; Q9H0S5" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.043" "0.985" "0.924" "1.025" "1.039" "1.006" "0.934" "1.060" "2.112" "394.1" "411.2" "388.1" "364.0" "404.0" "409.2" "396.6" "368.1" "417.5" "832.3" "" "" "" "" "" "" "" "" "" "" "349.4" "340.6" "338.6" "272.3" "336.8" "375.9" "335.2" "304.3" "382.9" "832.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054198857384115692" "False" "High" "IsMasterProtein" "O14492" "SH2B adapter protein 2 OS=Homo sapiens OX=9606 GN=SH2B2 PE=1 SV=2" "0.000" "False" "13.810" "7" "3" "3" "3" "632" "67.7" "6.27" "10.71" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00169, Pf08916" "10603" "ENSG00000160999" "SH2B2" "A0A0A0MTI2; A6ND74; O14492" "Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling" "5" "0" "0.956" "0.935" "0.973" "1.054" "0.940" "1.031" "0.745" "0.968" "4.234" "373.5" "357.2" "349.1" "363.5" "393.8" "351.0" "385.3" "278.1" "361.7" "1581.6" "" "" "" "" "" "" "" "" "" "" "331.2" "295.9" "304.6" "271.8" "328.4" "322.4" "325.6" "229.9" "331.7" "1581.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1674970657433919693" "False" "High" "IsMasterProtein" "P51159" "Ras-related protein Rab-27A OS=Homo sapiens OX=9606 GN=RAB27A PE=1 SV=3" "0.000" "False" "13.800" "10" "2" "2" "2" "221" "24.9" "5.22" "7.90" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5873" "ENSG00000069974" "RAB27A" "hsa:5873; O00195; P51159; Q6FI40; Q9UIR9; Q9Y5U3" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Insulin processing" "Deregulation of Rab and Rab effector genes in bladder cancer; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; 2q37 copy number variation syndrome" "7" "0" "1.034" "0.939" "0.923" "0.937" "1.027" "1.083" "1.047" "0.974" "0.620" "320.0" "330.9" "300.5" "295.3" "299.8" "328.6" "346.5" "335.1" "311.5" "198.2" "" "" "" "" "" "" "" "" "" "" "283.7" "274.1" "262.2" "220.9" "250.0" "301.8" "292.9" "277.0" "285.7" "198.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4344816618369671433" "False" "High" "IsMasterProtein" "Q16537" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1" "0.000" "False" "13.785" "6" "3" "4" "2" "467" "54.7" "6.95" "11.14" "3" "signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5529" "ENSG00000154001" "PPP2R5E" "A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "28" "0" "0.928" "0.811" "1.072" "0.919" "0.873" "1.082" "0.695" "0.894" "5.023" "244.2" "226.6" "197.9" "261.9" "224.4" "213.1" "264.1" "169.8" "218.4" "1226.6" "" "" "" "" "" "" "" "" "" "" "216.6" "187.7" "172.7" "195.9" "187.1" "195.8" "223.2" "140.4" "200.3" "1226.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2659436389650332532" "False" "High" "IsMasterProtein" "Q8TEQ0" "Sorting nexin-29 OS=Homo sapiens OX=9606 GN=SNX29 PE=1 SV=3" "0.000" "False" "13.782" "4" "2" "3" "1" "813" "91.2" "6.21" "12.93" "2" "" "" "other molecular function" "Pf00787, Pf02759" "92017" "ENSG00000048471" "SNX29" "B5MDW2; hsa:92017; Q8N2X2; Q8TEQ0; Q9HA26" "" "" "0" "0" "0.917" "0.651" "0.889" "0.651" "0.787" "0.663" "0.808" "0.804" "2.793" "16.7" "15.4" "10.9" "14.9" "10.9" "13.2" "11.1" "13.5" "13.5" "46.8" "" "" "" "" "" "" "" "" "" "" "14.9" "12.7" "9.5" "11.1" "9.1" "12.1" "9.4" "11.2" "12.4" "46.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986646952840969808" "False" "High" "IsMasterProtein" "Q9BUE6" "Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1" "0.000" "False" "13.779" "19" "2" "2" "2" "129" "14.2" "9.07" "6.91" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01521" "81689" "ENSG00000135070" "ISCA1" "B3KP34; B4DJI5; hsa:81689; Q8ND75; Q9BUE6; Q9BZR2" "Mitochondrial iron-sulfur cluster biogenesis" "" "1" "0" "0.921" "0.859" "1.160" "1.015" "0.984" "1.069" "1.042" "0.877" "1.170" "108.1" "99.6" "92.8" "125.4" "109.7" "106.4" "115.6" "112.7" "94.9" "126.6" "" "" "" "" "" "" "" "" "" "" "95.9" "82.5" "81.0" "93.8" "91.5" "97.7" "97.7" "93.1" "87.0" "126.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2508229497243424265" "False" "High" "IsMasterProtein" "P82673" "Small ribosomal subunit protein mS35 OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "0.000" "False" "13.778" "13" "4" "4" "4" "323" "36.8" "8.24" "13.19" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.987" "0.941" "0.992" "1.002" "1.009" "1.007" "0.804" "0.977" "3.062" "426.8" "421.2" "401.8" "423.3" "427.5" "430.6" "429.6" "343.2" "417.0" "1306.7" "" "" "" "" "" "" "" "" "" "" "378.5" "348.9" "350.6" "316.6" "356.5" "395.6" "363.1" "283.7" "382.5" "1306.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5427058765005465503" "False" "High" "IsMasterProtein" "Q7Z6I8" "UPF0461 protein C5orf24 OS=Homo sapiens OX=9606 GN=C5orf24 PE=1 SV=1" "0.000" "False" "13.776" "26" "3" "3" "3" "188" "20.1" "9.85" "9.01" "3" "" "" "" "Pf17724" "134553" "ENSG00000181904" "C5orf24" "D3DQA7; hsa:134553; Q7Z6I8; Q86Y53; Q8N1T9" "" "" "0" "0" "0.971" "0.929" "0.844" "0.889" "1.030" "0.879" "1.010" "0.916" "0.467" "309.7" "300.7" "287.7" "261.3" "275.5" "319.1" "272.3" "312.7" "283.7" "144.5" "" "" "" "" "" "" "" "" "" "" "274.7" "249.0" "251.0" "195.4" "229.7" "293.1" "230.1" "258.5" "260.1" "144.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "13.761" "3" "2" "2" "2" "793" "89.8" "7.56" "10.50" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "4" "0" "1.056" "0.855" "1.101" "0.883" "0.969" "0.837" "0.649" "0.818" "5.201" "41.3" "43.6" "35.3" "45.4" "36.4" "40.0" "34.6" "26.8" "33.8" "214.7" "" "" "" "" "" "" "" "" "" "" "36.6" "36.1" "30.8" "34.0" "30.4" "36.8" "29.2" "22.2" "31.0" "214.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6322413842474440718" "False" "High" "IsMasterProtein" "Q96IR7" "4-hydroxyphenylpyruvate dioxygenase-like protein OS=Homo sapiens OX=9606 GN=HPDL PE=1 SV=1" "0.000" "False" "13.755" "12" "3" "3" "3" "371" "39.4" "7.03" "12.08" "3" "other metabolic processes" "mitochondrion" "other molecular function" "" "84842" "ENSG00000186603" "HPDL" "B2R9B0; hsa:84842; Q96IR7" "" "" "0" "0" "1.123" "0.992" "1.186" "1.032" "1.066" "1.281" "1.109" "1.130" "0.650" "280.5" "315.0" "278.4" "332.8" "289.4" "299.1" "359.3" "311.1" "316.9" "182.4" "" "" "" "" "" "" "" "" "" "" "248.8" "260.9" "242.9" "248.9" "241.3" "274.7" "303.7" "257.2" "290.7" "182.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7708170732071910709" "False" "High" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "0.000" "False" "13.753" "7" "4" "4" "4" "591" "64.0" "9.73" "14.92" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "RHOG GTPase cycle; RAC2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "Integrin-mediated cell adhesion; Focal adhesion; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "25" "0" "1.027" "1.089" "0.983" "1.215" "1.180" "1.559" "1.531" "1.471" "1.966" "328.7" "337.4" "358.0" "323.2" "399.4" "387.7" "512.3" "503.2" "483.3" "646.1" "" "" "" "" "" "" "" "" "" "" "291.4" "279.5" "312.4" "241.7" "333.0" "356.2" "432.9" "415.9" "443.3" "646.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "203506742472389879" "False" "High" "IsMasterProtein" "Q5RL73" "RNA-binding protein 48 OS=Homo sapiens OX=9606 GN=RBM48 PE=1 SV=1" "0.000" "False" "13.743" "11" "4" "4" "4" "367" "41.8" "8.72" "14.32" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "" "84060" "ENSG00000127993" "RBM48" "B7Z2K5; B7ZL51; hsa:84060; Q5H9T2; Q5RL73; Q8IYW7; Q96NS0; Q9H0V7" "" "" "0" "0" "0.987" "1.082" "0.976" "0.935" "1.152" "0.953" "1.033" "1.089" "0.629" "223.9" "220.9" "242.3" "218.5" "209.4" "258.0" "213.5" "231.3" "243.9" "140.7" "" "" "" "" "" "" "" "" "" "" "198.6" "183.0" "211.4" "163.4" "174.6" "237.0" "180.4" "191.2" "223.7" "140.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "13.734" "5" "4" "4" "3" "723" "78.3" "5.58" "13.58" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654723519218057862" "False" "High" "IsMasterProtein" "Q9BXB5" "Oxysterol-binding protein-related protein 10 OS=Homo sapiens OX=9606 GN=OSBPL10 PE=1 SV=2" "0.000" "False" "13.727" "5" "3" "4" "3" "764" "83.9" "8.31" "15.93" "3" "other metabolic processes;transport" "other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "114884" "ENSG00000144645" "OSBPL10" "B4E212; hsa:114884; Q9BTU5; Q9BXB5" "Acyl chain remodelling of PS" "" "1" "0" "0.885" "0.903" "0.833" "0.950" "1.045" "0.679" "0.358" "0.835" "8.531" "56.6" "50.1" "51.1" "47.1" "53.7" "59.1" "38.4" "20.3" "47.2" "482.5" "" "" "" "" "" "" "" "" "" "" "50.2" "41.5" "44.6" "35.2" "44.8" "54.3" "32.4" "16.7" "43.3" "482.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9158242191706838173" "False" "High" "IsMasterProtein" "Q71RC2" "La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3" "0.000" "False" "13.709" "4" "3" "4" "3" "724" "80.5" "6.61" "6.53" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383" "113251" "ENSG00000161813" "LARP4" "A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9" "" "" "0" "0" "1.682" "0.976" "1.147" "1.245" "1.308" "1.212" "0.925" "1.168" "0.993" "358.1" "602.5" "349.6" "410.8" "445.8" "468.6" "434.0" "331.2" "418.5" "355.6" "" "" "" "" "" "" "" "" "" "" "317.6" "499.1" "305.0" "307.2" "371.8" "430.5" "366.8" "273.8" "383.8" "355.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.000" "False" "13.707" "8" "4" "5" "4" "551" "62.1" "8.40" "15.22" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "ISG15 antiviral mechanism; PKR-mediated signaling; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "16" "0" "1.170" "1.198" "1.203" "1.207" "1.006" "1.125" "0.764" "1.168" "6.068" "177.3" "207.4" "212.4" "213.3" "214.0" "178.3" "199.4" "135.4" "207.0" "1075.6" "" "" "" "" "" "" "" "" "" "" "157.2" "171.8" "185.3" "159.5" "178.4" "163.8" "168.5" "111.9" "189.8" "1075.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531116507177860716" "False" "High" "IsMasterProtein" "Q06609" "DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1" "0.000" "False" "13.694" "12" "3" "3" "3" "339" "36.9" "5.60" "12.36" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423, Pf14520" "5888" "ENSG00000051180" "RAD51" "B0FXP0; B2R8T6; hsa:5888; Q06609; Q6FHX9; Q6ZNA8; Q9BV60" "Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; Primary ovarian insufficiency; DNA damage response" "23" "0" "1.123" "0.914" "1.156" "1.128" "1.011" "1.394" "1.261" "1.041" "0.917" "276.4" "310.3" "252.7" "319.6" "311.8" "279.6" "385.2" "348.6" "287.8" "253.3" "" "" "" "" "" "" "" "" "" "" "245.1" "257.0" "220.5" "239.0" "260.0" "256.8" "325.6" "288.1" "263.9" "253.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514101839783017752" "False" "High" "IsMasterProtein" "Q9P021" "Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1" "0.000" "False" "13.687" "19" "2" "3" "2" "101" "11.2" "9.47" "11.83" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10235" "9419" "ENSG00000119878" "CRIPT" "hsa:9419; Q9P021" "" "" "0" "0" "1.182" "0.969" "1.157" "1.112" "1.057" "1.148" "1.190" "1.091" "0.514" "245.5" "290.2" "238.0" "284.1" "273.0" "259.5" "281.9" "292.1" "267.8" "126.1" "" "" "" "" "" "" "" "" "" "" "217.7" "240.4" "207.6" "212.5" "227.6" "238.3" "238.2" "241.5" "245.6" "126.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "High" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.000" "False" "13.654" "11" "3" "3" "3" "341" "37.6" "8.56" "12.85" "3" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "Signaling by BRAF and RAF1 fusions" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "3" "0" "0.898" "1.001" "0.960" "0.912" "0.960" "1.126" "0.839" "0.907" "2.356" "421.4" "378.5" "421.6" "404.4" "384.2" "404.5" "474.4" "353.4" "382.1" "992.7" "" "" "" "" "" "" "" "" "" "" "373.7" "313.5" "367.9" "302.4" "320.4" "371.6" "400.9" "292.1" "350.4" "992.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5919366994915360532" "False" "High" "IsMasterProtein" "Q8NI60" "Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1" "0.000" "False" "13.643" "7" "4" "5" "4" "647" "71.9" "6.99" "16.75" "4" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf03109" "56997" "ENSG00000163050" "COQ8A" "hsa:56997; Q5T7A5; Q63HK0; Q8NCJ6; Q8NI60; Q9HBQ1; Q9NQ67" "" "" "0" "0" "1.058" "0.980" "1.015" "1.097" "0.868" "1.001" "1.077" "1.000" "1.029" "194.0" "205.1" "190.0" "196.8" "212.8" "168.3" "194.2" "208.9" "194.0" "199.5" "" "" "" "" "" "" "" "" "" "" "172.0" "169.9" "165.8" "147.2" "177.4" "154.6" "164.1" "172.6" "177.9" "199.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3691090388992879642" "False" "High" "IsMasterProtein" "Cont_P02453" "Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3" "0.000" "True" "13.632" "3" "4" "7" "4" "1463" "138.9" "5.78" "19.77" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "extracellular structural activity;other molecular function" "Pf00093, Pf01391, Pf01410" "104990617; 109573749; 282187" "ENSBIXG00000001136; ENSBTAG00000013103" "COL1A1" "A0A4W2CI58; A0A6B0RVL7; A0A6P3HPH0; A0A6P5DEQ2; bbis:104990617; biu:109573749; bta:282187; P02453; Q3MHM2" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling" "Inflammatory response pathway; Osteoblast signaling; Focal adhesion" "19" "0" "1.856" "0.777" "2.612" "1.090" "2.894" "1.114" "0.805" "1.649" "0.378" "120.4" "223.5" "93.5" "314.4" "131.2" "348.4" "134.1" "96.9" "198.5" "45.5" "" "" "" "" "" "" "" "" "" "" "106.8" "185.1" "81.6" "235.2" "109.4" "320.1" "113.3" "80.1" "182.1" "45.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.000" "False" "13.624" "3" "5" "5" "5" "1555" "172.9" "8.48" "15.73" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "" "5" "0" "1.027" "0.936" "0.963" "0.935" "0.986" "0.911" "0.807" "0.932" "3.665" "525.0" "539.1" "491.2" "505.8" "491.0" "517.6" "478.3" "423.5" "489.3" "1924.1" "" "" "" "" "" "" "" "" "" "" "465.6" "446.5" "428.6" "378.3" "409.4" "475.5" "404.2" "350.1" "448.7" "1924.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2812564218304631981" "False" "High" "IsMasterProtein" "Q9NRD1" "F-box only protein 6 OS=Homo sapiens OX=9606 GN=FBXO6 PE=1 SV=1" "0.000" "False" "13.612" "11" "3" "5" "3" "293" "33.9" "6.09" "17.55" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf04300, Pf12937" "26270" "ENSG00000116663" "FBXO6" "B1AK42; B2RC88; hsa:26270; Q9NRD1; Q9UKT3" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "1.098" "1.012" "1.090" "0.933" "0.947" "1.019" "1.022" "0.920" "0.963" "259.6" "285.0" "262.9" "283.1" "242.2" "245.7" "264.5" "265.4" "238.7" "250.0" "" "" "" "" "" "" "" "" "" "" "230.2" "236.1" "229.4" "211.7" "201.9" "225.7" "223.6" "219.3" "219.0" "250.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-300411415202382779" "False" "High" "IsMasterProtein" "Q96NB1" "Centrosomal protein 20 OS=Homo sapiens OX=9606 GN=CEP20 PE=1 SV=1" "0.000" "False" "13.600" "16" "2" "2" "2" "174" "19.8" "7.15" "7.62" "2" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf09398" "123811" "ENSG00000133393; ENSG00000276914" "CEP20" "B3KPU9; hsa:123811; Q96NB1" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "0.954" "0.885" "0.867" "0.887" "0.812" "0.911" "0.918" "0.845" "0.723" "152.0" "144.9" "134.5" "131.8" "134.8" "123.4" "138.4" "139.5" "128.4" "109.8" "" "" "" "" "" "" "" "" "" "" "134.8" "120.0" "117.3" "98.6" "112.4" "113.3" "117.0" "115.3" "117.8" "109.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273003467290879098" "False" "High" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "0.000" "False" "13.570" "11" "3" "3" "3" "303" "34.8" "5.87" "10.43" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; O60526; Q969U2; Q9HBT1; Q9UNE7" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of TNFR1 signaling; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8051417909882487765" "False" "High" "IsMasterProtein" "Q14562" "ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1" "0.000" "False" "13.557" "3" "4" "5" "3" "1220" "139.2" "8.32" "13.98" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf00575, Pf04408, Pf07717, Pf21010" "1659" "ENSG00000067596" "DHX8" "hsa:1659; Q14562" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.163" "0.979" "1.186" "1.114" "1.001" "1.164" "1.010" "1.001" "1.304" "255.3" "297.0" "249.9" "302.7" "284.3" "255.5" "297.2" "257.7" "255.4" "332.8" "" "" "" "" "" "" "" "" "" "" "226.4" "246.0" "218.1" "226.4" "237.1" "234.7" "251.2" "213.0" "234.3" "332.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5558821625919889641" "False" "High" "IsMasterProtein" "Q9UDY4" "DnaJ homolog subfamily B member 4 OS=Homo sapiens OX=9606 GN=DNAJB4 PE=1 SV=1" "0.000" "False" "13.551" "10" "3" "3" "1" "337" "37.8" "8.50" "11.97" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00226, Pf01556" "11080" "ENSG00000162616" "DNAJB4" "B2R824; hsa:11080; Q13431; Q9UDY4" "" "VEGFA-VEGFR2 signaling" "1" "1" "0.930" "0.846" "0.906" "0.833" "0.910" "0.935" "0.773" "0.960" "2.489" "521.2" "484.7" "440.8" "472.1" "434.1" "474.1" "487.2" "402.9" "500.4" "1297.4" "" "" "" "" "" "" "" "" "" "" "462.2" "401.5" "384.6" "353.1" "361.9" "435.6" "411.7" "333.0" "458.9" "1297.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "921315881662704994" "False" "High" "IsMasterProtein" "O15040" "Tectonin beta-propeller repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=TECPR2 PE=1 SV=4" "0.000" "False" "13.550" "3" "4" "4" "4" "1411" "153.8" "5.55" "12.91" "4" "other metabolic processes;transport" "other cell component" "" "Pf06462, Pf19193" "9895" "ENSG00000196663" "TECPR2" "A5PKY3; A6NFY9; A7E2X3; H0YMM9; hsa:9895; O15040; Q9UEG6" "" "" "0" "0" "1.081" "0.929" "1.482" "1.070" "0.910" "1.155" "1.053" "0.828" "0.677" "48.3" "52.3" "44.9" "71.6" "51.7" "44.0" "55.9" "50.9" "40.0" "32.7" "" "" "" "" "" "" "" "" "" "" "42.9" "43.3" "39.2" "53.6" "43.1" "40.4" "47.2" "42.1" "36.7" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5424828533558395863" "False" "High" "IsMasterProtein" "O95352" "Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1" "0.000" "False" "13.540" "6" "5" "5" "5" "703" "77.9" "6.24" "15.29" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00899, Pf16420" "10533" "ENSG00000197548" "ATG7" "B4E170; E9PB95; hsa:10533; O95352; Q7L8L0; Q9BWP2; Q9UFH4" "Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy" "Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "12" "0" "1.040" "1.092" "1.096" "1.024" "1.043" "1.198" "1.161" "1.175" "1.499" "390.2" "405.8" "425.9" "427.6" "399.6" "407.0" "467.5" "453.1" "458.4" "584.7" "" "" "" "" "" "" "" "" "" "" "346.0" "336.2" "371.6" "319.8" "333.2" "373.9" "395.1" "374.5" "420.5" "584.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "469142345215753577" "False" "High" "IsMasterProtein" "Q9Y2R9" "Small ribosomal subunit protein uS7m OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "0.000" "False" "13.521" "17" "3" "3" "3" "242" "28.1" "9.99" "9.57" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.088" "0.856" "1.173" "0.985" "0.658" "1.037" "0.871" "0.883" "2.825" "146.9" "159.8" "125.7" "172.4" "144.7" "96.7" "152.3" "128.0" "129.7" "415.0" "" "" "" "" "" "" "" "" "" "" "130.3" "132.4" "109.7" "128.9" "120.7" "88.8" "128.7" "105.8" "118.9" "415.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8932263568853688601" "False" "High" "IsMasterProtein" "Q9UKA9" "Polypyrimidine tract-binding protein 2 OS=Homo sapiens OX=9606 GN=PTBP2 PE=1 SV=1" "0.000" "False" "13.510" "6" "4" "5" "3" "531" "57.5" "8.66" "19.38" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "58155" "ENSG00000117569" "PTBP2" "hsa:58155; Q8N0Z1; Q8N160; Q8NFB0; Q8NFB1; Q969N9; Q96Q76; Q9UKA9" "" "Genes targeted by miRNAs in adipocytes; mRNA processing" "2" "0" "1.001" "0.920" "1.057" "1.011" "0.908" "0.878" "0.299" "0.812" "12.587" "174.6" "174.9" "160.7" "184.5" "176.5" "158.6" "153.3" "52.2" "141.8" "2197.7" "" "" "" "" "" "" "" "" "" "" "154.8" "144.8" "140.2" "138.0" "147.2" "145.6" "129.6" "43.1" "130.0" "2197.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "13.509" "5" "3" "3" "3" "498" "56.9" "7.72" "10.47" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "Interferon gamma signaling" "" "1" "0" "0.904" "0.732" "1.057" "0.909" "1.108" "0.882" "0.010" "0.928" "16.184" "37.2" "33.6" "27.2" "39.3" "33.8" "41.2" "32.8" "0.0" "34.5" "602.1" "" "" "" "" "" "" "" "" "" "" "33.0" "27.9" "23.8" "29.4" "28.2" "37.9" "27.7" "0.0" "31.6" "602.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "High" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.000" "False" "13.498" "3" "2" "2" "2" "744" "82.3" "7.78" "8.71" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "M-decay: degradation of maternal mRNAs by maternally stored factors; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "Ciliary landscape" "4" "0" "0.976" "0.902" "0.988" "0.856" "0.995" "1.069" "0.838" "1.013" "5.395" "68.6" "67.0" "61.9" "67.8" "58.8" "68.2" "73.4" "57.5" "69.5" "370.1" "" "" "" "" "" "" "" "" "" "" "60.8" "55.5" "54.0" "50.7" "49.0" "62.7" "62.0" "47.5" "63.7" "370.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4099473831415028291" "False" "High" "IsMasterProtein" "Q15011" "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1" "0.000" "False" "13.484" "5" "2" "4" "1" "391" "43.7" "5.25" "12.36" "2" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00240" "9709" "ENSG00000051108" "HERPUD1" "E9PGD1; hsa:9709; O60644; Q15011; Q6IAN8; Q96D92" "ATF4 activates genes in response to endoplasmic reticulum stress" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "3" "0" "1.258" "1.111" "1.005" "1.237" "1.159" "1.108" "1.195" "1.097" "0.635" "71.5" "90.0" "79.5" "71.9" "88.5" "82.9" "79.3" "85.5" "78.5" "45.4" "" "" "" "" "" "" "" "" "" "" "63.4" "74.6" "69.3" "53.8" "73.8" "76.2" "67.0" "70.7" "72.0" "45.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1838412941252019118" "False" "High" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "0.000" "False" "13.470" "22" "3" "3" "3" "152" "17.0" "8.31" "9.53" "3" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "0.945" "0.909" "1.007" "1.002" "0.904" "0.999" "0.730" "0.839" "2.628" "124.7" "117.8" "113.3" "125.6" "125.0" "112.6" "124.6" "91.0" "104.6" "327.6" "" "" "" "" "" "" "" "" "" "" "110.6" "97.6" "98.9" "93.9" "104.2" "103.5" "105.3" "75.3" "95.9" "327.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.000" "False" "13.459" "5" "4" "4" "4" "931" "98.9" "5.86" "12.44" "4" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "" "2" "0" "1.029" "1.262" "1.165" "1.225" "0.988" "1.154" "1.103" "1.243" "1.769" "158.1" "162.7" "199.5" "184.2" "193.6" "156.1" "182.4" "174.4" "196.5" "279.7" "" "" "" "" "" "" "" "" "" "" "140.2" "134.7" "174.1" "137.8" "161.4" "143.4" "154.1" "144.2" "180.2" "279.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1094871198918048732" "False" "High" "IsMasterProtein" "O00287" "Regulatory factor X-associated protein OS=Homo sapiens OX=9606 GN=RFXAP PE=1 SV=1" "0.000" "False" "13.459" "13" "2" "2" "2" "272" "28.2" "5.54" "8.57" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf15289" "5994" "ENSG00000133111" "RFXAP" "B2R9T8; hsa:5994; O00287; Q5VZM6; Q8TC40" "" "" "0" "0" "1.004" "0.920" "1.060" "0.941" "1.012" "0.960" "0.955" "0.984" "0.656" "308.5" "309.6" "283.8" "326.9" "290.2" "312.1" "296.3" "294.7" "303.4" "202.2" "" "" "" "" "" "" "" "" "" "" "273.5" "256.5" "247.6" "244.5" "242.0" "286.7" "250.4" "243.6" "278.3" "202.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "287646480627839655" "False" "High" "IsMasterProtein" "Q6ZMZ0" "E3 ubiquitin-protein ligase RNF19B OS=Homo sapiens OX=9606 GN=RNF19B PE=1 SV=2" "0.000" "False" "13.452" "5" "2" "2" "2" "732" "77.9" "6.19" "8.77" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01485" "127544" "ENSG00000116514" "RNF19B" "B7ZLB2; E9PAW6; G3XA82; hsa:127544; Q0VG77; Q5TH44; Q5TH45; Q6P6A4; Q6ZMZ0; Q8N2S8; Q8WUF3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.463" "1.496" "1.285" "1.476" "0.990" "1.137" "1.053" "1.191" "1.099" "9.8" "14.4" "14.7" "12.6" "14.5" "9.7" "11.2" "10.3" "11.7" "10.8" "" "" "" "" "" "" "" "" "" "" "8.7" "11.9" "12.8" "9.4" "12.1" "8.9" "9.4" "8.6" "10.7" "10.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.000" "False" "13.451" "2" "1" "4" "1" "606" "63.8" "8.48" "15.93" "1" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "1.149" "0.948" "1.156" "1.157" "1.221" "0.834" "0.632" "1.153" "7.757" "36.4" "41.8" "34.5" "42.1" "42.1" "44.4" "30.4" "23.0" "42.0" "282.2" "" "" "" "" "" "" "" "" "" "" "32.3" "34.6" "30.1" "31.5" "35.1" "40.8" "25.7" "19.0" "38.5" "282.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7293098897812305004" "False" "High" "IsMasterProtein" "Q9Y623" "Myosin-4 OS=Homo sapiens OX=9606 GN=MYH4 PE=1 SV=2" "0.000" "False" "13.450" "1" "3" "4" "1" "1939" "222.9" "5.85" "12.57" "3" "other metabolic processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4622" "ENSG00000264424" "MYH4" "Q9Y623" "" "" "0" "0" "8.083" "0.976" "1.344" "0.938" "1.231" "1.129" "1.173" "1.080" "0.763" "177.1" "1431.4" "172.9" "238.0" "166.1" "218.1" "200.0" "207.7" "191.3" "135.0" "" "" "" "" "" "" "" "" "" "" "157.0" "1185.7" "150.8" "178.0" "138.5" "200.3" "169.0" "171.6" "175.4" "135.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139245110499108060" "False" "High" "IsMasterProtein" "P32942" "Intercellular adhesion molecule 3 OS=Homo sapiens OX=9606 GN=ICAM3 PE=1 SV=2" "0.000" "False" "13.449" "8" "4" "4" "4" "547" "59.5" "5.43" "11.48" "4" "cell adhesion;transport" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf03921, Pf21146" "3385" "ENSG00000076662" "ICAM3" "hsa:3385; P32942; Q6PD68" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "Ebola virus infection in host" "4" "0" "0.876" "0.801" "0.820" "0.852" "1.006" "0.669" "0.790" "1.053" "0.422" "104.9" "91.9" "84.0" "86.0" "89.4" "105.6" "70.2" "82.9" "110.5" "44.3" "" "" "" "" "" "" "" "" "" "" "93.1" "76.1" "73.3" "64.3" "74.5" "97.0" "59.3" "68.5" "101.3" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "13.437" "4" "3" "3" "3" "753" "81.8" "6.20" "11.84" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.138" "1.023" "1.053" "1.142" "1.231" "1.260" "1.256" "1.218" "1.491" "171.4" "195.1" "175.2" "180.5" "195.7" "210.9" "216.0" "215.2" "208.7" "255.5" "" "" "" "" "" "" "" "" "" "" "152.0" "161.6" "152.9" "135.0" "163.2" "193.7" "182.5" "177.8" "191.4" "255.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334556934018890015" "False" "High" "IsMasterProtein" "P51808" "Dynein light chain Tctex-type 3 OS=Homo sapiens OX=9606 GN=DYNLT3 PE=1 SV=1" "0.000" "False" "13.435" "23" "2" "3" "2" "116" "13.1" "5.66" "16.12" "2" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03645" "6990" "ENSG00000165169" "DYNLT3" "hsa:6990; P51808; Q6ICS3" "" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Orexin receptor pathway" "4" "0" "1.017" "1.050" "1.072" "1.108" "1.086" "1.251" "1.205" "1.099" "0.946" "479.7" "488.0" "503.5" "514.2" "531.5" "520.9" "599.9" "578.2" "527.3" "453.7" "" "" "" "" "" "" "" "" "" "" "425.4" "404.3" "439.3" "384.5" "443.2" "478.5" "507.0" "477.9" "483.6" "453.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3983981062552353097" "False" "High" "IsMasterProtein" "Q92600" "CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1" "0.000" "False" "13.404" "10" "3" "3" "3" "299" "33.6" "8.03" "11.51" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04078" "9125" "ENSG00000144580" "CNOT9" "B2RPI0; B5MDQ4; B7Z1E5; hsa:9125; Q92600; Q96IX4" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "4" "0" "1.008" "0.986" "1.001" "1.019" "1.005" "1.207" "0.972" "1.222" "3.340" "301.5" "304.0" "297.2" "301.7" "307.1" "303.1" "364.1" "293.2" "368.5" "1007.0" "" "" "" "" "" "" "" "" "" "" "267.4" "251.8" "259.3" "225.6" "256.1" "278.5" "307.7" "242.3" "337.9" "1007.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3056828042948797118" "False" "High" "IsMasterProtein" "Q9Y5B6" "PAX3- and PAX7-binding protein 1 OS=Homo sapiens OX=9606 GN=PAXBP1 PE=1 SV=2" "0.000" "False" "13.403" "4" "2" "2" "2" "917" "104.7" "5.68" "11.16" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf07842" "94104" "ENSG00000159086; ENSG00000263141" "PAXBP1" "D3DSE7; hsa:94104; Q96DU8; Q9NYQ0; Q9Y5B6" "" "" "0" "0" "0.883" "0.787" "0.790" "0.812" "0.840" "0.818" "0.762" "0.749" "0.663" "117.7" "104.0" "92.6" "93.0" "95.6" "98.9" "96.3" "89.7" "88.2" "78.0" "" "" "" "" "" "" "" "" "" "" "104.4" "86.1" "80.8" "69.6" "79.7" "90.9" "81.4" "74.1" "80.9" "78.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2648921608470054018" "False" "High" "IsMasterProtein" "Q96L92" "Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2" "0.000" "False" "13.395" "5" "3" "5" "3" "541" "61.2" "6.49" "14.68" "3" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595, Pf00787, Pf00788" "81609" "ENSG00000143376" "SNX27" "hsa:81609; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q96L92; Q9H3K8" "" "" "0" "0" "1.084" "0.776" "1.044" "0.880" "0.896" "0.996" "0.612" "0.982" "6.650" "118.1" "128.1" "91.7" "123.3" "103.9" "105.8" "117.7" "72.4" "116.0" "785.6" "" "" "" "" "" "" "" "" "" "" "104.8" "106.1" "80.0" "92.2" "86.7" "97.2" "99.5" "59.8" "106.4" "785.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4822956659812595428" "False" "High" "IsMasterProtein" "P17706" "Tyrosine-protein phosphatase non-receptor type 2 OS=Homo sapiens OX=9606 GN=PTPN2 PE=1 SV=2" "0.000" "False" "13.388" "9" "3" "3" "3" "415" "48.4" "8.29" "12.44" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5771" "ENSG00000175354" "PTPN2" "A8K955; A8MXU3; hsa:5771; K7ENG3; P17706; Q96AU5; Q96HR2" "PKR-mediated signaling; Negative regulation of MET activity; Interleukin-37 signaling" "Immune response to tuberculosis; 5q35 copy number variation" "5" "0" "1.134" "1.011" "1.177" "0.993" "0.962" "1.128" "0.423" "1.041" "10.939" "158.4" "179.7" "160.1" "186.5" "157.2" "152.3" "178.6" "67.0" "164.9" "1732.4" "" "" "" "" "" "" "" "" "" "" "140.4" "148.8" "139.7" "139.4" "131.1" "139.9" "151.0" "55.4" "151.2" "1732.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "961314597478386434" "False" "High" "IsMasterProtein" "P57740" "Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1" "0.000" "False" "13.386" "3" "3" "3" "3" "925" "106.3" "5.43" "11.88" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04121" "57122" "ENSG00000111581" "NUP107" "B4DZ67; hsa:57122; P57740; Q6PJE1" "Separation of Sister Chromatids; RHO GTPases Activate Formins; HCMV Late Events; Resolution of Sister Chromatid Cohesion; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "Gastric cancer network 1; Primary ovarian insufficiency" "37" "0" "0.857" "0.895" "1.159" "0.912" "0.760" "1.099" "1.034" "0.963" "3.313" "237.8" "203.8" "212.8" "275.5" "216.8" "180.7" "261.4" "245.9" "229.0" "787.9" "" "" "" "" "" "" "" "" "" "" "210.9" "168.9" "185.7" "206.1" "180.8" "166.0" "221.0" "203.2" "210.0" "787.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "336772770148819757" "False" "High" "IsMasterProtein" "Q9NVR0" "Kelch-like protein 11 OS=Homo sapiens OX=9606 GN=KLHL11 PE=1 SV=1" "0.000" "False" "13.374" "6" "5" "6" "5" "708" "80.1" "6.16" "14.86" "5" "" "cytosol" "" "Pf00651, Pf01344, Pf07707" "55175" "ENSG00000178502" "KLHL11" "hsa:55175; Q9NVR0" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "1.088" "0.929" "1.042" "0.984" "1.119" "0.968" "1.022" "0.918" "1.338" "674.7" "734.0" "626.7" "703.3" "663.7" "755.0" "653.3" "689.5" "619.3" "902.5" "" "" "" "" "" "" "" "" "" "" "598.3" "608.0" "546.8" "526.0" "553.5" "693.5" "552.1" "569.9" "568.0" "902.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.000" "False" "13.372" "5" "5" "6" "5" "845" "98.3" "6.62" "17.85" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "38" "0" "0.684" "0.749" "0.633" "0.854" "0.681" "0.761" "0.043" "0.953" "18.208" "64.0" "43.8" "48.0" "40.5" "54.7" "43.6" "48.7" "2.8" "61.0" "1166.2" "" "" "" "" "" "" "" "" "" "" "56.8" "36.3" "41.9" "30.3" "45.6" "40.1" "41.2" "2.3" "56.0" "1166.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5739848343521747817" "False" "High" "IsMasterProtein" "Q5TEU4" "Arginine-hydroxylase NDUFAF5, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF5 PE=1 SV=1" "0.000" "False" "13.361" "9" "3" "3" "3" "345" "38.9" "6.57" "7.70" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf08241" "79133" "ENSG00000101247" "NDUFAF5" "A8K166; hsa:79133; Q5TEU4; Q6GPH3; Q9H6F4" "Complex I biogenesis" "" "1" "0" "1.145" "1.079" "1.275" "1.197" "1.175" "1.173" "1.231" "1.040" "0.443" "154.7" "177.3" "167.0" "197.4" "185.2" "181.8" "181.5" "190.5" "160.9" "68.5" "" "" "" "" "" "" "" "" "" "" "137.2" "146.8" "145.7" "147.6" "154.4" "167.0" "153.4" "157.5" "147.6" "68.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8965718931841673636" "False" "High" "IsMasterProtein" "Q9Y496" "Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4" "0.000" "False" "13.327" "6" "4" "5" "3" "699" "80.0" "6.54" "15.53" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "11127" "ENSG00000131437" "KIF3A" "A8MSW9; hsa:11127; Q59EN1; Q86XE9; Q9Y496; Q9Y6V4" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO" "Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling" "11" "0" "1.023" "0.855" "0.987" "0.913" "0.861" "0.808" "0.796" "1.219" "2.821" "118.0" "120.7" "100.8" "116.5" "107.7" "101.6" "95.3" "93.9" "143.8" "332.7" "" "" "" "" "" "" "" "" "" "" "104.6" "100.0" "88.0" "87.1" "89.8" "93.3" "80.6" "77.6" "131.9" "332.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7180208613807174562" "False" "High" "IsMasterProtein" "P16118" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=PFKFB1 PE=1 SV=3" "0.000" "False" "13.315" "8" "4" "4" "1" "471" "54.6" "6.58" "10.82" "4" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00300, Pf01591" "5207" "ENSG00000158571" "PFKFB1" "B2RA88; B4DUN5; hsa:5207; P16118; Q5JXS5; Q99951" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; PKA-mediated phosphorylation of key metabolic factors; PP2A-mediated dephosphorylation of key metabolic factors" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2492385812914646204" "False" "High" "IsMasterProtein" "O14730" "Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2" "0.000" "False" "13.295" "8" "5" "5" "5" "519" "59.1" "5.76" "15.36" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01163" "8780" "ENSG00000101782" "RIOK3" "O14730; Q8IXN9" "Major pathway of rRNA processing in the nucleolus and cytosol" "Hematopoietic stem cell differentiation" "2" "0" "0.915" "0.932" "0.950" "0.974" "0.826" "0.948" "1.015" "0.995" "0.801" "425.2" "389.2" "396.4" "404.0" "414.1" "351.2" "402.9" "431.7" "422.8" "340.7" "" "" "" "" "" "" "" "" "" "" "377.0" "322.4" "345.9" "302.2" "345.3" "322.6" "340.6" "356.8" "387.8" "340.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827121188594037217" "False" "High" "IsMasterProtein" "Q6P1R4" "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS1L PE=1 SV=1" "0.000" "False" "13.281" "12" "4" "4" "4" "473" "53.2" "8.29" "12.76" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "64118" "ENSG00000169718" "DUS1L" "A6NHV4; hsa:64118; Q6P1R4; Q96AI3" "" "" "0" "0" "1.114" "1.056" "1.207" "1.148" "1.201" "0.932" "0.886" "0.932" "1.342" "248.3" "276.6" "262.3" "299.6" "285.1" "298.2" "231.5" "219.9" "231.5" "333.2" "" "" "" "" "" "" "" "" "" "" "220.2" "229.1" "228.8" "224.1" "237.7" "274.0" "195.7" "181.8" "212.3" "333.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6000200469823771153" "False" "High" "IsMasterProtein" "P63272" "Transcription elongation factor SPT4 OS=Homo sapiens OX=9606 GN=SUPT4H1 PE=1 SV=1" "0.000" "False" "13.278" "17" "1" "2" "1" "117" "13.2" "8.06" "10.28" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf06093" "6827" "ENSG00000213246" "SUPT4H1" "B2R4X8; D3DTZ4; hsa:6827; P63272; Q16550; Q62387; Q6ZP89" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "Initiation of transcription and translation elongation at the HIV-1 LTR" "16" "0" "0.857" "1.052" "0.890" "1.058" "1.133" "0.953" "0.997" "1.135" "1.468" "150.3" "128.8" "158.1" "133.8" "158.9" "170.3" "143.1" "149.7" "170.5" "220.6" "" "" "" "" "" "" "" "" "" "" "133.3" "106.7" "137.9" "100.1" "132.5" "156.4" "121.0" "123.8" "156.4" "220.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1396372760161625634" "False" "High" "IsMasterProtein" "Q8N129" "Protein canopy homolog 4 OS=Homo sapiens OX=9606 GN=CNPY4 PE=1 SV=1" "0.000" "False" "13.275" "14" "3" "4" "3" "248" "28.3" "4.64" "13.37" "3" "other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf11938" "245812" "ENSG00000166997" "CNPY4" "hsa:245812; Q8N129; Q8WUN9" "" "" "0" "0" "1.031" "1.023" "1.141" "1.058" "1.020" "1.215" "1.133" "1.159" "0.984" "174.7" "180.2" "178.8" "199.3" "184.8" "178.1" "212.2" "198.0" "202.5" "172.0" "" "" "" "" "" "" "" "" "" "" "154.9" "149.2" "156.0" "149.1" "154.1" "163.6" "179.4" "163.7" "185.7" "172.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7538327877078952516" "False" "High" "IsMasterProtein" "Q9UK33" "Zinc finger protein 580 OS=Homo sapiens OX=9606 GN=ZNF580 PE=1 SV=1" "0.000" "False" "13.261" "20" "3" "3" "3" "172" "18.7" "10.08" "13.43" "3" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "51157" "ENSG00000213015" "ZNF580" "B2RC05; hsa:51157; Q9NPP7; Q9UK33" "" "" "0" "0" "0.993" "0.944" "0.994" "1.004" "0.936" "0.901" "0.847" "0.876" "0.562" "522.6" "519.2" "493.3" "519.5" "524.9" "489.4" "470.8" "442.6" "457.8" "293.6" "" "" "" "" "" "" "" "" "" "" "463.4" "430.1" "430.4" "388.5" "437.7" "449.5" "397.9" "365.8" "419.9" "293.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8937681193743142864" "False" "High" "IsMasterProtein" "Q9P1F3" "Costars family protein ABRACL OS=Homo sapiens OX=9606 GN=ABRACL PE=1 SV=1" "0.000" "False" "13.209" "47" "3" "3" "3" "81" "9.1" "6.29" "9.42" "3" "other biological processes" "" "" "Pf14705" "58527" "ENSG00000146386" "ABRACL" "hsa:58527; Q5SZC8; Q9P0A1; Q9P1F3" "" "" "0" "0" "1.011" "1.117" "0.808" "0.859" "0.806" "1.021" "1.082" "1.318" "0.351" "468.0" "473.2" "522.6" "378.2" "402.2" "377.1" "477.7" "506.2" "617.1" "164.4" "" "" "" "" "" "" "" "" "" "" "415.1" "392.0" "456.0" "282.9" "335.4" "346.4" "403.8" "418.4" "566.0" "164.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6360176631635833399" "False" "High" "IsMasterProtein" "P25054" "Adenomatous polyposis coli protein OS=Homo sapiens OX=9606 GN=APC PE=1 SV=2" "0.000" "False" "13.193" "2" "4" "4" "4" "2843" "311.5" "7.80" "10.90" "4" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00514, Pf05923, Pf05924, Pf05937, Pf05956, Pf05972, Pf11414, Pf16629, Pf16630, Pf16633, Pf16634, Pf16635, Pf16636, Pf16689, Pf18797" "324" "ENSG00000134982" "APC" "B7Z2B6; D3DT03; hsa:324; P25054; Q15162; Q15163; Q93042" "Deactivation of the beta-catenin transactivating complex; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Ovarian tumor domain proteases; Apoptotic cleavage of cellular proteins; APC truncation mutants are not K63 polyubiquitinated" "Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Gastric cancer network 1; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Copper homeostasis; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Regulation of sister chromatid separation at the metaphase-anaphase transition; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Cohesin complex - Cornelia de Lange syndrome; Alzheimer's disease; 2q21.1 copy number variation syndrome; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent)" "45" "0" "1.169" "1.086" "1.134" "1.192" "1.095" "1.500" "1.143" "1.391" "0.794" "33.0" "38.5" "35.8" "37.4" "39.3" "36.1" "49.4" "37.7" "45.8" "26.2" "" "" "" "" "" "" "" "" "" "" "29.2" "31.9" "31.2" "27.9" "32.7" "33.1" "41.8" "31.1" "42.0" "26.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190260410723795831" "False" "High" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "0.000" "False" "13.192" "13" "4" "5" "4" "317" "36.9" "4.40" "14.35" "4" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202, Pf13499" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "0.865" "0.979" "1.012" "0.988" "1.099" "0.959" "0.924" "1.027" "1.705" "381.1" "329.5" "373.0" "385.5" "376.5" "418.8" "365.6" "352.2" "391.5" "649.9" "" "" "" "" "" "" "" "" "" "" "338.0" "273.0" "325.5" "288.3" "314.0" "384.7" "309.0" "291.1" "359.1" "649.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316251485158664462" "False" "High" "IsMasterProtein" "Q8N8A6" "ATP-dependent RNA helicase DDX51 OS=Homo sapiens OX=9606 GN=DDX51 PE=1 SV=3" "0.000" "False" "13.188" "2" "1" "3" "1" "666" "72.4" "8.16" "11.64" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "317781" "ENSG00000185163; ENSG00000288503" "DDX51" "A8MPT9; hsa:317781; Q5CZ71; Q8IXK5; Q8N8A6; Q96ED1" "" "" "0" "0" "1.147" "1.177" "1.301" "1.201" "1.037" "0.982" "1.089" "1.059" "1.030" "59.9" "68.7" "70.5" "78.0" "72.0" "62.1" "58.8" "65.3" "63.4" "61.7" "" "" "" "" "" "" "" "" "" "" "53.1" "56.9" "61.5" "58.3" "60.0" "57.1" "49.7" "54.0" "58.2" "61.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086845665992869030" "False" "High" "IsMasterProtein" "O94991" "SLIT and NTRK-like protein 5 OS=Homo sapiens OX=9606 GN=SLITRK5 PE=1 SV=2" "0.000" "False" "13.177" "3" "3" "4" "3" "958" "107.4" "6.95" "14.09" "3" "cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf13855" "26050" "ENSG00000165300" "SLITRK5" "B3KNB8; B4DSH5; hsa:26050; O94991; Q5VT81" "RAC2 GTPase cycle; RAC3 GTPase cycle; Receptor-type tyrosine-protein phosphatases" "" "3" "0" "0.835" "0.920" "1.020" "0.909" "0.697" "0.691" "0.945" "0.880" "0.751" "161.8" "135.2" "148.9" "165.0" "147.1" "112.8" "111.8" "152.9" "142.4" "121.5" "" "" "" "" "" "" "" "" "" "" "143.5" "112.0" "129.9" "123.4" "122.7" "103.7" "94.5" "126.4" "130.6" "121.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "273952586028610460" "False" "High" "IsMasterProtein" "Q63HQ0" "AP-1 complex-associated regulatory protein OS=Homo sapiens OX=9606 GN=AP1AR PE=1 SV=1" "0.000" "False" "13.154" "10" "2" "2" "2" "302" "34.3" "4.87" "11.03" "2" "cell adhesion;transport;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf15745" "55435" "ENSG00000138660" "AP1AR" "B2RCV7; hsa:55435; Q63HQ0; Q96GG6; Q9H0V0; Q9P1L4" "" "" "0" "0" "0.935" "0.901" "0.889" "0.919" "0.858" "0.939" "0.901" "0.931" "0.754" "459.3" "429.4" "413.8" "408.5" "422.2" "394.1" "431.5" "414.0" "427.6" "346.5" "" "" "" "" "" "" "" "" "" "" "407.3" "355.7" "361.0" "305.5" "352.1" "362.0" "364.7" "342.2" "392.1" "346.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5696513608973606523" "False" "High" "IsMasterProtein" "Q86VQ1" "Glucocorticoid-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=GLCCI1 PE=1 SV=1" "0.000" "False" "13.153" "5" "3" "3" "3" "547" "58.0" "9.44" "10.35" "3" "" "other cell component" "" "Pf15388" "113263" "ENSG00000106415" "GLCCI1" "A4D103; hsa:113263; Q86VQ1; Q96FD0" "" "" "0" "0" "1.087" "1.130" "0.935" "1.065" "1.109" "0.937" "0.949" "0.922" "0.520" "210.1" "228.4" "237.4" "196.5" "223.8" "233.1" "196.8" "199.4" "193.6" "109.2" "" "" "" "" "" "" "" "" "" "" "186.3" "189.2" "207.1" "146.9" "186.6" "214.1" "166.3" "164.8" "177.6" "109.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590031244663879657" "False" "High" "IsMasterProtein" "P47224" "Guanine nucleotide exchange factor MSS4 OS=Homo sapiens OX=9606 GN=RABIF PE=1 SV=2" "0.000" "False" "13.147" "25" "2" "2" "2" "123" "13.8" "5.52" "10.66" "2" "cell organization and biogenesis;transport;signal transduction" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf04421" "5877" "ENSG00000183155" "RABIF" "B2R4P4; hsa:5877; P47224; Q92992" "" "Retinoblastoma gene in cancer" "1" "0" "1.013" "1.013" "1.185" "1.093" "1.150" "1.153" "1.330" "1.252" "1.187" "113.3" "114.7" "114.7" "134.2" "123.8" "130.3" "130.6" "150.6" "141.8" "134.4" "" "" "" "" "" "" "" "" "" "" "100.5" "95.0" "100.1" "100.4" "103.3" "119.7" "110.4" "124.5" "130.1" "134.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5858537743821975597" "False" "High" "IsMasterProtein" "O75843" "AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1" "0.000" "False" "13.147" "4" "3" "3" "3" "785" "87.1" "6.55" "10.45" "3" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf02883" "8906" "ENSG00000213983" "AP1G2" "D3DS51; hsa:8906; O75504; O75843" "Lysosome Vesicle Biogenesis" "" "1" "0" "1.004" "0.996" "0.898" "0.973" "0.970" "0.916" "0.607" "0.947" "6.952" "64.7" "65.0" "64.5" "58.1" "62.9" "62.8" "59.3" "39.2" "61.3" "449.9" "" "" "" "" "" "" "" "" "" "" "57.4" "53.8" "56.2" "43.5" "52.5" "57.7" "50.1" "32.4" "56.2" "449.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6358620098822443937" "False" "High" "IsMasterProtein" "Q8TDB4" "Protein MGARP OS=Homo sapiens OX=9606 GN=MGARP PE=1 SV=1" "0.000" "False" "13.144" "15" "2" "2" "2" "240" "25.4" "4.44" "9.67" "2" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "" "Pf14962" "84709" "ENSG00000137463" "MGARP" "hsa:84709; Q8TDB4; Q9BZC3" "" "" "0" "0" "0.961" "0.931" "0.901" "0.943" "1.099" "0.862" "1.018" "0.999" "0.188" "455.2" "437.6" "423.6" "410.1" "429.2" "500.3" "392.6" "463.3" "454.9" "85.8" "" "" "" "" "" "" "" "" "" "" "403.7" "362.5" "369.6" "306.7" "357.9" "459.6" "331.8" "382.9" "417.2" "85.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1558588285545917257" "False" "High" "IsMasterProtein" "O75531" "Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1" "0.000" "False" "13.129" "37" "6" "20" "6" "89" "10.1" "6.09" "54.77" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02961" "8815" "ENSG00000175334" "BANF1" "hsa:8815; O60558; O75531; Q6FGG7" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy; Progeria-associated lipodystrophy" "11" "0" "1.008" "0.923" "0.940" "0.880" "0.842" "0.882" "1.036" "1.004" "0.117" "3130.2" "3154.5" "2888.1" "2942.6" "2753.2" "2634.1" "2762.1" "3241.3" "3143.6" "367.2" "" "" "" "" "" "" "" "" "" "" "2775.8" "2613.0" "2520.0" "2200.7" "2295.8" "2419.7" "2334.4" "2679.2" "2883.1" "367.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6338677437993936073" "False" "High" "IsMasterProtein" "P30305" "M-phase inducer phosphatase 2 OS=Homo sapiens OX=9606 GN=CDC25B PE=1 SV=2" "0.000" "False" "13.118" "4" "2" "3" "2" "580" "64.9" "6.40" "9.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00581, Pf06617" "994" "ENSG00000101224" "CDC25B" "D3DVY1; D3DVY2; D3DVY3; D3DVY4; hsa:994; O43551; P30305; Q13971; Q5JX77; Q6RSS1; Q9BRA6" "Cyclin A/B1/B2 associated events during G2/M transition; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; Retinoblastoma gene in cancer; MAPK signaling pathway" "8" "0" "0.945" "0.955" "1.014" "1.142" "1.141" "1.745" "1.758" "1.729" "1.122" "50.2" "47.4" "47.9" "50.9" "57.3" "57.3" "87.6" "88.3" "86.8" "56.3" "" "" "" "" "" "" "" "" "" "" "44.5" "39.3" "41.8" "38.1" "47.8" "52.6" "74.1" "73.0" "79.6" "56.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-39268026158598830" "False" "High" "IsMasterProtein" "P20138" "Myeloid cell surface antigen CD33 OS=Homo sapiens OX=9606 GN=CD33 PE=1 SV=2" "0.000" "False" "13.114" "9" "3" "3" "3" "364" "39.8" "8.38" "12.27" "3" "cell adhesion;cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00047, Pf07686" "945" "ENSG00000105383" "CD33" "B4E3P8; C9JEN7; F8WAL2; hsa:945; P20138; Q8TD24" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Neutrophil degranulation" "" "2" "0" "1.009" "1.033" "0.955" "0.957" "1.026" "0.976" "1.036" "1.030" "0.382" "681.6" "687.5" "704.1" "650.7" "652.3" "699.1" "665.0" "706.4" "702.1" "260.2" "" "" "" "" "" "" "" "" "" "" "604.4" "569.5" "614.4" "486.6" "543.9" "642.2" "562.0" "583.9" "644.0" "260.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948996399981661341" "False" "High" "IsMasterProtein" "Q2TAL8" "Transcriptional regulator QRICH1 OS=Homo sapiens OX=9606 GN=QRICH1 PE=1 SV=1" "0.000" "False" "13.113" "6" "4" "4" "4" "776" "86.4" "5.87" "12.61" "4" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf12012" "54870" "ENSG00000198218" "QRICH1" "hsa:54870; Q2TAL8; Q4G0F7; Q7L621; Q8TEA5" "" "" "0" "0" "0.984" "0.965" "0.802" "0.824" "0.718" "0.678" "0.621" "0.891" "5.396" "249.0" "245.0" "240.4" "199.8" "205.2" "178.8" "168.9" "154.6" "221.9" "1343.6" "" "" "" "" "" "" "" "" "" "" "220.8" "202.9" "209.7" "149.4" "171.1" "164.2" "142.8" "127.8" "203.5" "1343.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8757079958512544915" "False" "High" "IsMasterProtein" "Q96DE5" "Anaphase-promoting complex subunit 16 OS=Homo sapiens OX=9606 GN=ANAPC16 PE=1 SV=1" "0.000" "False" "13.103" "17" "2" "3" "2" "110" "11.7" "4.97" "9.14" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf17256" "119504" "ENSG00000166295" "ANAPC16" "hsa:119504; Q96DE5" "Separation of Sister Chromatids; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "17" "0" "0.871" "0.878" "0.998" "0.999" "0.895" "0.844" "0.846" "0.870" "0.931" "445.6" "388.3" "391.3" "444.7" "445.3" "398.7" "376.1" "377.0" "387.6" "415.1" "" "" "" "" "" "" "" "" "" "" "395.2" "321.6" "341.4" "332.6" "371.3" "366.3" "317.8" "311.6" "355.5" "415.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635036141062544876" "False" "High" "IsMasterProtein" "P52655" "Transcription initiation factor IIA subunit 1 OS=Homo sapiens OX=9606 GN=GTF2A1 PE=1 SV=1" "0.000" "False" "13.087" "3" "1" "2" "1" "376" "41.5" "4.55" "8.42" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03153" "2957" "ENSG00000165417" "GTF2A1" "hsa:2957; P52655; Q3KNQ9" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "" "10" "0" "0.888" "0.919" "0.969" "0.945" "0.961" "0.991" "0.899" "0.769" "0.378" "142.4" "126.4" "130.9" "138.1" "134.6" "136.8" "141.2" "128.1" "109.6" "53.8" "" "" "" "" "" "" "" "" "" "" "126.3" "104.7" "114.2" "103.3" "112.2" "125.7" "119.3" "105.9" "100.5" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1179356982440791831" "False" "High" "IsMasterProtein" "Q6ZNW5" "GDP-D-glucose phosphorylase 1 OS=Homo sapiens OX=9606 GN=GDPGP1 PE=1 SV=2" "0.000" "False" "13.053" "10" "4" "4" "4" "385" "42.3" "6.47" "14.27" "4" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "" "390637" "ENSG00000183208" "GDPGP1" "hsa:390637; Q6ZNW5" "" "" "0" "0" "1.238" "1.128" "1.214" "1.242" "1.054" "0.985" "0.889" "0.884" "1.005" "283.6" "351.0" "320.0" "344.3" "352.3" "299.0" "279.3" "252.2" "250.6" "285.1" "" "" "" "" "" "" "" "" "" "" "251.5" "290.8" "279.2" "257.5" "293.8" "274.6" "236.0" "208.5" "229.8" "285.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516330367870273472" "False" "High" "IsMasterProtein" "P09086" "POU domain, class 2, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU2F2 PE=1 SV=3" "0.000" "False" "13.002" "7" "3" "4" "3" "479" "51.2" "8.43" "13.98" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5452" "ENSG00000028277" "POU2F2" "hsa:5452; P09086; Q16648; Q7M4M8; Q9BRS4" "RNA polymerase II transcribes snRNA genes" "Ectoderm differentiation; Prion disease pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "4" "0" "1.056" "0.918" "0.858" "0.833" "0.852" "0.927" "0.717" "0.799" "5.929" "121.3" "128.1" "111.4" "104.1" "101.1" "103.4" "112.5" "87.0" "96.9" "719.2" "" "" "" "" "" "" "" "" "" "" "107.6" "106.1" "97.2" "77.8" "84.3" "94.9" "95.1" "71.9" "88.9" "719.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-646999670011784093" "False" "High" "IsMasterProtein" "Q96S55" "ATPase WRNIP1 OS=Homo sapiens OX=9606 GN=WRNIP1 PE=1 SV=2" "0.000" "False" "13.001" "5" "3" "3" "3" "665" "72.1" "6.10" "13.94" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf12002, Pf16193, Pf18279" "56897" "ENSG00000124535" "WRNIP1" "B2RDB0; hsa:56897; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q96S55; Q9H681; Q9NRJ6" "" "" "0" "0" "0.866" "0.919" "0.632" "0.683" "0.803" "0.772" "0.668" "0.831" "1.701" "86.8" "75.2" "79.8" "54.9" "59.3" "69.7" "67.0" "58.0" "72.1" "147.7" "" "" "" "" "" "" "" "" "" "" "77.0" "62.3" "69.6" "41.1" "49.5" "64.0" "56.6" "47.9" "66.1" "147.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1078046361948541096" "False" "High" "IsMasterProtein" "Q6UWP2" "Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1" "0.000" "False" "12.979" "12" "3" "3" "3" "260" "28.3" "6.64" "11.68" "3" "other metabolic processes" "non-structural extracellular" "other molecular function" "Pf00106" "79154" "ENSG00000275397; ENSG00000278535" "DHRS11" "A0A0U5BLD0; B2RDZ3; hsa:79154; Q6UWP2; Q9BUC7; Q9H674" "" "17q12 copy number variation syndrome" "1" "0" "1.102" "1.150" "1.115" "1.253" "1.108" "1.171" "1.155" "1.171" "1.043" "257.7" "284.1" "296.3" "287.4" "322.9" "285.5" "301.8" "297.8" "301.7" "268.8" "" "" "" "" "" "" "" "" "" "" "228.6" "235.3" "258.6" "214.9" "269.3" "262.3" "255.0" "246.1" "276.7" "268.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755296670490160775" "False" "High" "IsMasterProtein" "Q96SB3" "Neurabin-2 OS=Homo sapiens OX=9606 GN=PPP1R9B PE=1 SV=3" "0.000" "False" "12.976" "4" "3" "5" "3" "817" "89.3" "4.97" "15.32" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00595, Pf17817" "84687" "ENSG00000108819" "PPP1R9B" "D3DTX6; hsa:84687; Q8TCR9; Q96SB3" "" "" "0" "0" "0.780" "0.834" "1.002" "0.648" "0.613" "0.877" "0.745" "0.596" "0.629" "25.5" "19.9" "21.3" "25.6" "16.5" "15.6" "22.4" "19.0" "15.2" "16.0" "" "" "" "" "" "" "" "" "" "" "22.6" "16.5" "18.6" "19.1" "13.8" "14.4" "18.9" "15.7" "13.9" "16.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417947325093162762" "False" "High" "IsMasterProtein" "Q49A26" "Cytokine-like nuclear factor N-PAC OS=Homo sapiens OX=9606 GN=GLYR1 PE=1 SV=4" "0.000" "False" "12.950" "6" "3" "3" "3" "553" "60.5" "9.17" "10.08" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf03446, Pf14833" "84656" "ENSG00000140632" "GLYR1" "B4DL47; C9JJ40; C9JJ60; hsa:84656; Q49A26; Q5U632; Q6P1Q2; Q6V3W7; Q9BTI1; Q9BXK2" "" "" "0" "0" "1.013" "1.073" "1.276" "1.183" "1.128" "1.188" "1.045" "1.246" "0.675" "47.5" "48.1" "50.9" "60.6" "56.2" "53.5" "56.4" "49.6" "59.1" "32.0" "" "" "" "" "" "" "" "" "" "" "42.1" "39.8" "44.4" "45.3" "46.8" "49.1" "47.7" "41.0" "54.2" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "High" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.000" "False" "12.948" "1" "4" "4" "4" "3664" "402.0" "7.64" "10.26" "4" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "RHOBTB1 GTPase cycle" "Notch signaling pathway" "2" "0" "0.938" "0.774" "0.860" "0.949" "0.879" "0.821" "0.783" "0.760" "2.123" "143.2" "134.4" "110.9" "123.1" "135.9" "125.9" "117.5" "112.1" "108.8" "304.0" "" "" "" "" "" "" "" "" "" "" "127.0" "111.3" "96.7" "92.1" "113.3" "115.6" "99.3" "92.7" "99.8" "304.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3749115953426157303" "False" "High" "IsMasterProtein" "Q6PGN9" "Proline/serine-rich coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=PSRC1 PE=1 SV=1" "0.000" "False" "12.919" "7" "2" "2" "2" "363" "38.8" "11.21" "8.24" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf15259" "84722" "ENSG00000134222" "PSRC1" "hsa:84722; Q5T2Z3; Q6PGN9; Q6ZTI8; Q71MG3; Q9BV77" "" "Aryl hydrocarbon receptor pathway" "1" "0" "0.960" "0.870" "0.925" "0.867" "0.884" "0.653" "0.667" "0.709" "0.756" "331.5" "318.3" "288.6" "306.8" "287.4" "293.1" "216.5" "221.0" "235.2" "250.6" "" "" "" "" "" "" "" "" "" "" "294.0" "263.7" "251.8" "229.4" "239.6" "269.2" "183.0" "182.7" "215.7" "250.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5448927889689110920" "False" "High" "IsMasterProtein" "Q16539" "Mitogen-activated protein kinase 14 OS=Homo sapiens OX=9606 GN=MAPK14 PE=1 SV=3" "0.000" "False" "12.916" "10" "3" "6" "2" "360" "41.3" "5.78" "10.17" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1432" "ENSG00000112062" "MAPK14" "A6ZJ92; A8K6P4; B0LPH0; B5TY32; hsa:1432; O60776; Q13083; Q14084; Q16539; Q8TDX0" "Neutrophil degranulation; Regulation of TP53 Activity through Phosphorylation; VEGFA-VEGFR2 Pathway; DSCAM interactions; RHO GTPases Activate NADPH Oxidases; Myogenesis; ERK/MAPK targets; Oxidative Stress Induced Senescence; ADP signalling through P2Y purinoceptor 1; NOD1/2 Signaling Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; KSRP (KHSRP) binds and destabilizes mRNA; Activation of the AP-1 family of transcription factors; Platelet sensitization by LDL; CD163 mediating an anti-inflammatory response" "Physiological and pathological hypertrophy of the heart; Angiogenesis; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Oxidative stress response; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Regulatory circuits of the STAT3 signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; Th17 cell differentiation pathway; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; IL-19 signaling pathway; Interferon type I signaling pathways; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Monoamine transport; Toll-like receptor signaling pathway" "92" "0" "0.953" "0.927" "1.034" "0.914" "1.021" "0.989" "0.888" "1.006" "1.655" "125.1" "119.3" "115.9" "129.4" "114.3" "127.7" "123.8" "111.1" "125.9" "207.0" "" "" "" "" "" "" "" "" "" "" "110.9" "98.8" "101.2" "96.8" "95.3" "117.3" "104.6" "91.8" "115.5" "207.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1367534402013747077" "False" "High" "IsMasterProtein" "O75947" "ATP synthase subunit d, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PD PE=1 SV=3" "0.000" "False" "12.912" "22" "4" "4" "4" "161" "18.5" "5.30" "11.08" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05873" "10476" "ENSG00000167863" "ATP5PD" "B2R5L6; hsa:10476; O75947; Q9H3J4" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "5" "0" "1.051" "1.128" "1.026" "1.259" "1.202" "1.131" "1.087" "1.183" "0.814" "548.7" "576.4" "618.7" "563.2" "690.5" "659.3" "620.8" "596.5" "649.0" "446.7" "" "" "" "" "" "" "" "" "" "" "486.6" "477.5" "539.8" "421.2" "575.8" "605.7" "524.6" "493.1" "595.2" "446.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "582663252060756755" "False" "High" "IsMasterProtein" "Q9NVX7" "Kelch repeat and BTB domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KBTBD4 PE=1 SV=4" "0.000" "False" "12.908" "8" "4" "4" "4" "534" "59.9" "5.77" "11.82" "4" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.108" "1.071" "1.146" "1.086" "1.082" "1.206" "1.136" "1.048" "0.756" "176.9" "195.9" "189.5" "202.8" "192.0" "191.4" "213.3" "200.9" "185.4" "133.7" "" "" "" "" "" "" "" "" "" "" "156.8" "162.3" "165.3" "151.6" "160.1" "175.8" "180.3" "166.1" "170.0" "133.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2540636687362609874" "False" "High" "IsMasterProtein" "O94768" "Serine/threonine-protein kinase 17B OS=Homo sapiens OX=9606 GN=STK17B PE=1 SV=1" "0.000" "False" "12.907" "9" "3" "3" "3" "372" "42.3" "5.25" "10.62" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9262" "ENSG00000081320" "STK17B" "hsa:9262; O94768" "" "" "0" "0" "1.790" "0.998" "1.095" "1.100" "1.079" "1.005" "0.617" "1.189" "8.157" "238.7" "427.2" "238.3" "261.4" "262.4" "257.5" "239.8" "147.4" "283.8" "1946.9" "" "" "" "" "" "" "" "" "" "" "211.6" "353.9" "207.9" "195.5" "218.8" "236.6" "202.7" "121.8" "260.3" "1946.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3257917255703740656" "False" "High" "IsMasterProtein" "Q14181" "DNA polymerase alpha subunit B OS=Homo sapiens OX=9606 GN=POLA2 PE=1 SV=2" "0.000" "False" "12.883" "7" "4" "5" "4" "598" "65.9" "5.24" "16.18" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus" "nucleic acid binding activity" "Pf04042, Pf08418" "23649" "ENSG00000014138" "POLA2" "B4DNB4; hsa:23649; Q14181; Q9BPV3" "Defective pyroptosis; Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "12" "0" "1.000" "0.946" "1.036" "0.955" "0.976" "0.975" "0.809" "0.964" "4.350" "340.3" "340.4" "322.0" "352.3" "324.9" "332.2" "331.7" "275.2" "328.1" "1480.2" "" "" "" "" "" "" "" "" "" "" "301.7" "282.0" "281.0" "263.5" "270.9" "305.2" "280.4" "227.5" "300.9" "1480.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8481325661535348808" "False" "High" "IsMasterProtein" "P46019" "Phosphorylase b kinase regulatory subunit alpha, liver isoform OS=Homo sapiens OX=9606 GN=PHKA2 PE=1 SV=1" "0.000" "False" "12.880" "4" "4" "4" "4" "1235" "138.3" "6.44" "12.78" "4" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00723, Pf19292" "5256" "ENSG00000044446" "PHKA2" "A8K1T1; hsa:5256; P46019; Q6LAJ5; Q7Z6W0; Q96CR3; Q9UDA1" "Glycogen breakdown (glycogenolysis)" "Type II diabetes mellitus; Glycogen synthesis and degradation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2089333689475724176" "False" "High" "IsMasterProtein" "Q9BTM9" "Ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=URM1 PE=1 SV=1" "0.000" "False" "12.878" "13" "1" "6" "1" "101" "11.4" "4.67" "23.40" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf09138" "81605" "ENSG00000167118" "URM1" "B3KMH3; B4DV08; hsa:81605; Q5T4B4; Q9BTM9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.033" "0.930" "1.175" "1.006" "1.000" "1.039" "1.002" "0.913" "0.986" "548.7" "566.8" "510.3" "644.8" "552.2" "548.9" "570.3" "549.7" "500.8" "540.7" "" "" "" "" "" "" "" "" "" "" "486.5" "469.5" "445.3" "482.2" "460.4" "504.2" "482.0" "454.3" "459.3" "540.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "529818675588363220" "False" "High" "IsMasterProtein" "O95674" "Phosphatidate cytidylyltransferase 2 OS=Homo sapiens OX=9606 GN=CDS2 PE=1 SV=1" "0.000" "False" "12.875" "5" "2" "2" "2" "445" "51.4" "7.09" "8.28" "2" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf01148" "8760" "ENSG00000101290" "CDS2" "B2RDC6; D3DW04; hsa:8760; O95674; Q5TDY2; Q5TDY3; Q5TDY4; Q5TDY5; Q9BYK5; Q9NTT2" "Synthesis of PG" "" "1" "0" "1.060" "0.971" "0.605" "1.053" "1.054" "0.903" "1.045" "1.058" "0.341" "143.5" "152.1" "139.3" "86.9" "151.1" "151.2" "129.5" "150.0" "151.8" "49.0" "" "" "" "" "" "" "" "" "" "" "127.3" "126.0" "121.6" "65.0" "126.0" "138.9" "109.5" "124.0" "139.3" "49.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "127392206666109507" "False" "High" "IsMasterProtein" "O95166" "Gamma-aminobutyric acid receptor-associated protein OS=Homo sapiens OX=9606 GN=GABARAP PE=1 SV=1" "0.000" "False" "12.872" "15" "3" "7" "1" "117" "13.9" "8.79" "21.43" "3" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11337" "ENSG00000170296" "GABARAP" "hsa:11337; O95166" "Macroautophagy; TBC/RABGAPs" "2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "4" "0" "0.717" "0.770" "0.769" "0.790" "0.855" "0.885" "0.789" "0.830" "0.673" "129.3" "92.7" "99.6" "99.4" "102.1" "110.6" "114.4" "102.0" "107.4" "87.0" "" "" "" "" "" "" "" "" "" "" "114.6" "76.8" "86.9" "74.4" "85.2" "101.6" "96.7" "84.3" "98.5" "87.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3310116821494939621" "False" "High" "IsMasterProtein" "O00584" "Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2" "0.000" "False" "12.858" "12" "3" "3" "3" "256" "29.5" "7.08" "10.41" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "non-structural extracellular;mitochondrion;ER/Golgi;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00445" "8635" "ENSG00000026297" "RNASET2" "B2RDA7; E1P5C3; hsa:8635; O00584; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47" "Neutrophil degranulation" "" "1" "0" "0.981" "0.976" "0.952" "0.950" "1.033" "1.037" "1.001" "1.022" "0.818" "331.3" "324.9" "323.3" "315.5" "314.8" "342.3" "343.4" "331.5" "338.5" "271.1" "" "" "" "" "" "" "" "" "" "" "293.8" "269.1" "282.1" "236.0" "262.5" "314.5" "290.3" "274.0" "310.4" "271.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1443049690155721947" "False" "High" "IsMasterProtein" "Q9H0E2" "Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1" "0.000" "False" "12.850" "14" "4" "7" "4" "274" "30.3" "5.97" "20.89" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf02845" "54472" "ENSG00000078902; ENSG00000291426" "TOLLIP" "B3KXC6; hsa:54472; Q9H0E2; Q9H9E6; Q9UJ69" "Neutrophil degranulation; Interleukin-1 signaling" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling related to MyD88; Signal transduction through IL1R; Toll-like receptor signaling pathway" "7" "0" "1.180" "0.934" "1.155" "1.056" "1.048" "1.109" "0.912" "0.945" "1.409" "422.0" "498.0" "394.1" "487.6" "445.6" "442.1" "468.1" "384.8" "398.6" "594.6" "" "" "" "" "" "" "" "" "" "" "374.2" "412.5" "343.9" "364.6" "371.6" "406.1" "395.6" "318.0" "365.6" "594.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5623462440984321357" "False" "High" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "0.000" "False" "12.843" "5" "4" "6" "4" "907" "103.5" "8.12" "13.57" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "0.898" "0.895" "0.924" "0.851" "0.899" "0.934" "0.809" "0.784" "2.824" "312.7" "280.7" "279.7" "288.8" "266.0" "281.2" "292.0" "253.0" "245.1" "882.9" "" "" "" "" "" "" "" "" "" "" "277.3" "232.5" "244.0" "216.0" "221.8" "258.3" "246.8" "209.1" "224.8" "882.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045429465415994492" "False" "High" "IsMasterProtein" "Q3ZCQ8" "Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2" "0.000" "False" "12.842" "6" "2" "2" "2" "353" "39.6" "8.37" "9.61" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;mitochondrion;nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03031" "92609" "ENSG00000105197" "TIMM50" "hsa:92609; Q330K1; Q3ZCQ8; Q6QA00; Q96FJ5; Q96GY2; Q9H370" "Mitochondrial protein import" "" "1" "0" "0.956" "1.161" "1.119" "1.115" "0.815" "1.145" "0.848" "0.979" "0.149" "53.0" "50.6" "61.5" "59.3" "59.0" "43.2" "60.7" "44.9" "51.9" "7.9" "" "" "" "" "" "" "" "" "" "" "47.0" "42.0" "53.7" "44.3" "49.2" "39.6" "51.3" "37.1" "47.6" "7.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291509197618805102" "False" "High" "IsMasterProtein" "Cont_Q3SZ57" "Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1" "0.000" "True" "12.838" "5" "4" "5" "3" "610" "68.5" "6.29" "14.20" "4" "other metabolic processes;developmental processes;signal transduction" "non-structural extracellular;other cell component" "other molecular function" "Pf00273" "506011" "ENSBIXG00000005150; ENSBTAG00000017131" "AFP" "A0A4W2DDK5; bta:506011; Q3SZ57" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "12.817" "4" "4" "7" "1" "727" "83.8" "6.28" "16.98" "4" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "Chemokine signaling pathway; CCL18 signaling pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667568518827666272" "False" "High" "IsMasterProtein" "O94762" "ATP-dependent DNA helicase Q5 OS=Homo sapiens OX=9606 GN=RECQL5 PE=1 SV=2" "0.000" "False" "12.801" "5" "5" "6" "5" "991" "108.8" "8.56" "19.21" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf06959, Pf16124" "9400" "ENSG00000108469" "RECQL5" "hsa:9400; O94762; Q6P4G0; Q9H0B1; Q9P1W7; Q9UNC8" "" "" "0" "0" "0.894" "0.794" "0.963" "0.779" "0.845" "0.710" "0.555" "0.736" "3.774" "124.8" "111.6" "99.1" "120.2" "97.2" "105.4" "88.6" "69.3" "91.9" "470.9" "" "" "" "" "" "" "" "" "" "" "110.6" "92.4" "86.4" "89.9" "81.0" "96.9" "74.9" "57.3" "84.3" "470.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2204752013873116397" "False" "High" "IsMasterProtein" "Q8IV20" "Purine nucleoside phosphorylase LACC1 OS=Homo sapiens OX=9606 GN=LACC1 PE=1 SV=1" "0.000" "False" "12.799" "6" "2" "3" "2" "430" "47.7" "7.06" "7.15" "2" "stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf02578" "144811" "ENSG00000179630" "LACC1" "A2A3Z6; hsa:144811; Q8IV20; Q8N8X5" "" "" "0" "0" "1.265" "1.244" "1.143" "1.350" "1.229" "1.078" "1.107" "0.946" "0.700" "230.1" "291.0" "286.2" "262.9" "310.6" "282.7" "248.0" "254.6" "217.7" "161.1" "" "" "" "" "" "" "" "" "" "" "204.0" "241.0" "249.7" "196.6" "259.0" "259.7" "209.6" "210.5" "199.6" "161.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4489677363022304149" "False" "High" "IsMasterProtein" "Q8IYU8" "Calcium uptake protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=MICU2 PE=1 SV=2" "0.000" "False" "12.798" "7" "2" "2" "2" "434" "49.6" "9.09" "6.94" "2" "transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "221154" "ENSG00000165487" "MICU2" "hsa:221154; Q8IYU8; Q8N0T6; Q8NAX8" "Mitochondrial protein degradation; Processing of SMDT1" "" "3" "0" "0.829" "0.889" "0.797" "0.938" "0.970" "0.787" "0.960" "1.000" "0.525" "234.2" "194.2" "208.2" "186.6" "219.8" "227.1" "184.3" "224.9" "234.2" "123.0" "" "" "" "" "" "" "" "" "" "" "207.7" "160.8" "181.7" "139.6" "183.3" "208.7" "155.7" "185.9" "214.8" "123.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454272078180370625" "False" "High" "IsMasterProtein" "P20226" "TATA-box-binding protein OS=Homo sapiens OX=9606 GN=TBP PE=1 SV=2" "0.000" "False" "12.796" "10" "4" "4" "4" "339" "37.7" "9.79" "10.45" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00352" "6908" "ENSG00000112592" "TBP" "B4E3B3; F5H869; hsa:6908; P20226; Q16845; Q6IBM6; Q9UC02" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; Regulation of TP53 Activity through Phosphorylation; SIRT1 negatively regulates rRNA expression" "Prion disease pathway; Eukaryotic transcription initiation" "23" "0" "0.990" "0.973" "0.913" "0.934" "1.025" "0.813" "0.752" "0.803" "1.750" "762.5" "754.5" "741.9" "696.4" "712.5" "781.2" "620.0" "573.6" "612.3" "1334.3" "" "" "" "" "" "" "" "" "" "" "676.1" "625.0" "647.3" "520.8" "594.1" "717.6" "524.0" "474.1" "561.6" "1334.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9085174644749999284" "False" "High" "IsMasterProtein" "Q4G0F5" "Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2" "0.000" "False" "12.789" "11" "4" "8" "2" "336" "39.1" "7.36" "22.69" "4" "stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "112936" "ENSG00000151502" "VPS26B" "hsa:112936; Q4G0F5; Q96A55" "" "" "0" "0" "1.015" "0.789" "0.991" "0.973" "0.996" "0.890" "0.887" "0.834" "0.707" "89.3" "90.6" "70.5" "88.4" "86.9" "89.0" "79.4" "79.2" "74.5" "63.1" "" "" "" "" "" "" "" "" "" "" "79.2" "75.1" "61.5" "66.1" "72.4" "81.7" "67.1" "65.4" "68.3" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4814601069630724909" "False" "High" "IsMasterProtein" "Q15906" "Vacuolar protein sorting-associated protein 72 homolog OS=Homo sapiens OX=9606 GN=VPS72 PE=1 SV=1" "0.000" "False" "12.779" "11" "4" "6" "4" "364" "40.6" "6.48" "18.93" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05764, Pf08265" "6944" "ENSG00000163159" "VPS72" "A6NLK9; A6PW55; hsa:6944; Q15906; Q53GJ2; Q5U0R4" "HATs acetylate histones" "" "1" "0" "0.930" "0.959" "0.879" "0.920" "1.000" "0.920" "0.887" "0.918" "1.234" "358.1" "332.9" "343.3" "314.7" "329.3" "358.2" "329.5" "317.6" "328.6" "441.7" "" "" "" "" "" "" "" "" "" "" "317.5" "275.7" "299.5" "235.4" "274.6" "329.1" "278.5" "262.5" "301.3" "441.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146373126346510516" "False" "High" "IsMasterProtein" "Q96SL8" "Flt3-interacting zinc finger protein 1 OS=Homo sapiens OX=9606 GN=FIZ1 PE=1 SV=2" "0.000" "False" "12.770" "5" "2" "3" "2" "496" "52.0" "8.19" "12.35" "2" "other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00096" "84922" "ENSG00000179943" "FIZ1" "A2RU72; Q6ZMJ7; Q96SL8" "" "" "0" "0" "1.038" "0.830" "0.585" "0.928" "0.994" "1.034" "0.964" "0.911" "1.157" "87.6" "90.9" "72.7" "51.3" "81.3" "87.1" "90.6" "84.5" "79.8" "101.4" "" "" "" "" "" "" "" "" "" "" "77.7" "75.3" "63.5" "38.3" "67.8" "80.0" "76.6" "69.8" "73.2" "101.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4765552648658305889" "False" "High" "IsMasterProtein" "Q96JH7" "Deubiquitinating protein VCPIP1 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2" "0.000" "False" "12.749" "4" "4" "4" "4" "1222" "134.2" "7.20" "12.87" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02338, Pf19437, Pf21403" "80124" "ENSG00000175073" "VCPIP1" "hsa:80124; Q504T4; Q86T93; Q86W01; Q8N3A9; Q96JH7; Q9H5R8" "Ovarian tumor domain proteases" "Alstrom syndrome" "2" "0" "2.449" "0.814" "0.954" "0.814" "0.923" "0.906" "0.726" "0.986" "3.545" "132.9" "325.5" "108.2" "126.8" "108.1" "122.6" "120.4" "96.5" "131.0" "471.1" "" "" "" "" "" "" "" "" "" "" "117.9" "269.6" "94.4" "94.8" "90.2" "112.7" "101.8" "79.7" "120.2" "471.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3090856641429635389" "False" "High" "IsMasterProtein" "Q16637" "Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN2 PE=1 SV=1" "0.000" "False" "12.746" "10" "2" "2" "2" "294" "31.8" "6.55" "8.38" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06003, Pf20635, Pf20636" "6606; 6607" "ENSG00000172062; ENSG00000205571; ENSG00000273772; ENSG00000275349; ENSG00000277773" "SMN1; SMN2" "A8K0V4; hsa:6606; hsa:6607; Q13119; Q16637; Q549U5; Q96J51" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "1.037" "0.921" "1.075" "1.042" "1.010" "0.904" "0.836" "0.970" "3.767" "330.6" "343.0" "304.4" "355.5" "344.6" "333.8" "299.0" "276.3" "320.9" "1245.5" "" "" "" "" "" "" "" "" "" "" "293.2" "284.1" "265.6" "265.9" "287.3" "306.6" "252.7" "228.4" "294.3" "1245.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538396539459298741" "False" "High" "IsMasterProtein" "Q9H6Q4" "Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1" "0.000" "False" "12.743" "7" "3" "3" "3" "476" "53.0" "7.23" "10.27" "3" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "other molecular function" "Pf02256, Pf02906" "64428" "ENSG00000103245" "CIAO3" "A1L385; B3KTJ3; hsa:64428; Q53GC6; Q96S10; Q9H6J8; Q9H6Q4" "Cytosolic iron-sulfur cluster assembly" "" "1" "0" "1.065" "0.978" "1.077" "1.011" "1.144" "1.016" "1.019" "0.913" "0.712" "267.3" "284.6" "261.6" "288.0" "270.3" "305.8" "271.7" "272.5" "244.0" "190.3" "" "" "" "" "" "" "" "" "" "" "237.1" "235.8" "228.2" "215.4" "225.4" "280.9" "229.6" "225.2" "223.8" "190.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4949581647878709913" "False" "High" "IsMasterProtein" "Q7Z7A1" "Centriolin OS=Homo sapiens OX=9606 GN=CNTRL PE=1 SV=2" "0.000" "False" "12.735" "1" "3" "3" "3" "2325" "268.7" "5.55" "8.62" "3" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf14580" "11064" "ENSG00000119397" "CNTRL" "A2A2Y1; B2RP67; hsa:11064; Q3MN79; Q5FWF8; Q5JVD0; Q6MZR3; Q6PKC1; Q7Z7A1; Q8TEP3; Q9Y489" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.248" "0.978" "1.384" "1.248" "0.948" "1.248" "1.082" "0.941" "1.187" "149.9" "187.1" "146.7" "207.4" "187.1" "142.2" "187.1" "162.2" "141.0" "177.9" "" "" "" "" "" "" "" "" "" "" "132.9" "155.0" "128.0" "155.1" "156.0" "130.6" "158.1" "134.1" "129.4" "177.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137976061761612537" "False" "High" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "0.000" "False" "12.708" "4" "5" "5" "4" "942" "103.9" "6.37" "14.54" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "10" "0" "1.153" "1.174" "0.956" "0.958" "1.077" "1.193" "1.020" "1.313" "6.293" "51.9" "59.8" "60.9" "49.6" "49.7" "55.9" "61.9" "52.9" "68.1" "326.5" "" "" "" "" "" "" "" "" "" "" "46.0" "49.5" "53.2" "37.1" "41.4" "51.3" "52.3" "43.8" "62.5" "326.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.000" "False" "12.707" "1" "4" "4" "4" "3184" "353.4" "6.32" "11.09" "4" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "" "10q11.21q11.23 copy number variation syndrome" "1" "0" "1.043" "0.897" "0.964" "0.868" "0.760" "0.943" "0.378" "1.135" "9.227" "76.8" "80.1" "68.9" "74.0" "66.6" "58.3" "72.4" "29.0" "87.1" "708.4" "" "" "" "" "" "" "" "" "" "" "68.1" "66.4" "60.1" "55.3" "55.6" "53.6" "61.2" "24.0" "79.9" "708.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8184976527645465360" "False" "High" "IsMasterProtein" "Q8N5M4" "Tetratricopeptide repeat protein 9C OS=Homo sapiens OX=9606 GN=TTC9C PE=1 SV=1" "0.000" "False" "12.700" "19" "3" "3" "3" "171" "20.0" "8.92" "10.49" "3" "" "" "" "Pf14559" "283237" "ENSG00000162222" "TTC9C" "hsa:283237; Q8N5M4; Q8WYY7" "" "" "0" "0" "1.015" "0.981" "0.925" "1.025" "1.029" "0.935" "0.988" "1.030" "1.788" "253.6" "257.5" "248.7" "234.6" "260.0" "261.0" "237.2" "250.5" "261.1" "453.4" "" "" "" "" "" "" "" "" "" "" "224.9" "213.3" "217.0" "175.4" "216.8" "239.8" "200.5" "207.1" "239.5" "453.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2806673757180566722" "False" "High" "IsMasterProtein" "P54709" "Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1" "0.000" "False" "12.691" "15" "4" "4" "4" "279" "31.5" "8.35" "13.59" "4" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00287" "483" "ENSG00000069849" "ATP1B3" "B7Z1N7; hsa:483; P54709" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases; Basigin interactions" "Calcium regulation in cardiac cells" "5" "0" "1.119" "0.835" "1.262" "1.105" "1.004" "1.273" "0.984" "1.283" "0.793" "127.6" "142.8" "106.5" "161.1" "141.0" "128.2" "162.5" "125.6" "163.7" "101.3" "" "" "" "" "" "" "" "" "" "" "113.2" "118.3" "92.9" "120.5" "117.6" "117.7" "137.3" "103.8" "150.1" "101.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5567467987070279927" "False" "High" "IsMasterProtein" "Q96CV9" "Optineurin OS=Homo sapiens OX=9606 GN=OPTN PE=1 SV=3" "0.000" "False" "12.690" "7" "4" "5" "4" "577" "65.9" "5.17" "14.34" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11577, Pf16516, Pf18414" "10133" "ENSG00000123240" "OPTN" "B3KP00; D3DRS4; D3DRS8; hsa:10133; Q5T672; Q5T673; Q5T674; Q5T675; Q7LDL9; Q8N562; Q96CV9; Q9UET9; Q9UEV4; Q9Y218" "Regulation of PLK1 Activity at G2/M Transition; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TBC/RABGAPs; TNFR1-induced proapoptotic signaling" "HDAC6 interactions in the central nervous system" "6" "0" "0.967" "0.915" "0.826" "0.810" "0.754" "0.766" "0.735" "0.953" "1.779" "624.2" "603.6" "571.2" "515.5" "505.5" "470.7" "478.4" "458.6" "594.7" "1110.6" "" "" "" "" "" "" "" "" "" "" "553.5" "500.0" "498.4" "385.5" "421.5" "432.4" "404.3" "379.0" "545.4" "1110.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2309309010695254198" "False" "High" "IsMasterProtein" "Q7Z6J8" "E3 ubiquitin-protein ligase E3D OS=Homo sapiens OX=9606 GN=UBE3D PE=1 SV=2" "0.000" "False" "12.672" "4" "1" "2" "1" "389" "43.6" "8.13" "10.18" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09814" "90025" "ENSG00000118420" "UBE3D" "B4DP63; hsa:90025; Q5T4W2; Q6IPR4; Q75UG0; Q7Z6J8; Q9NT42" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.175" "1.086" "1.399" "1.243" "0.993" "1.371" "1.132" "1.017" "1.087" "41.3" "48.6" "44.9" "57.8" "51.4" "41.1" "56.7" "46.8" "42.1" "44.9" "" "" "" "" "" "" "" "" "" "" "36.7" "40.2" "39.2" "43.3" "42.9" "37.7" "47.9" "38.7" "38.6" "44.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-142769344711843061" "False" "High" "IsMasterProtein" "P60468" "Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2" "0.000" "False" "12.660" "22" "2" "3" "2" "96" "10.0" "11.56" "10.31" "2" "protein metabolism;other metabolic processes;stress response;transport" "other membranes;cytosol;ER/Golgi" "translation activity;other molecular function" "Pf03911" "10952" "ENSG00000106803" "SEC61B" "hsa:10952; P38390; P38391; P60468; Q6IBC1" "ER-Phagosome pathway; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; SRP-dependent cotranslational protein targeting to membrane" "" "3" "0" "0.919" "0.970" "0.935" "0.932" "1.084" "0.878" "1.008" "0.924" "0.351" "377.6" "346.9" "366.4" "353.2" "352.1" "409.3" "331.7" "380.7" "349.0" "132.7" "" "" "" "" "" "" "" "" "" "" "334.9" "287.3" "319.7" "264.1" "293.6" "376.0" "280.3" "314.6" "320.1" "132.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4893836570063627970" "False" "High" "IsMasterProtein" "O75494" "Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1" "0.000" "False" "12.644" "11" "3" "3" "3" "262" "31.3" "11.27" "10.28" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10772" "ENSG00000188529" "SRSF10" "A6NFM6; A6NI42; A6NIU7; B4DJP9; hsa:10772; O60572; O75494; Q5JRH9; Q5JRI0; Q5JRI2; Q5JRI3; Q5JRI4; Q96G09; Q96P17" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "1.226" "1.111" "1.282" "1.194" "1.177" "1.244" "1.250" "1.117" "1.471" "166.7" "204.3" "185.2" "213.7" "199.1" "196.3" "207.3" "208.3" "186.2" "245.3" "" "" "" "" "" "" "" "" "" "" "147.8" "169.3" "161.6" "159.8" "166.0" "180.3" "175.2" "172.2" "170.8" "245.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3525614426972172152" "False" "High" "IsMasterProtein" "Q96JN0" "Ligand-dependent corepressor OS=Homo sapiens OX=9606 GN=LCOR PE=1 SV=2" "0.000" "False" "12.620" "3" "1" "2" "1" "433" "47.0" "9.38" "8.69" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf05225" "84458" "ENSG00000196233" "LCOR" "D3DR47; hsa:84458; Q5VW16; Q7Z723; Q86T32; Q86T33; Q8N3L6; Q8N655; Q96JN0; Q9H945; Q9Y457" "" "" "0" "0" "1.110" "1.098" "1.334" "1.208" "0.992" "0.973" "0.927" "0.976" "0.655" "38.2" "42.4" "42.0" "51.0" "46.2" "37.9" "37.2" "35.5" "37.3" "25.0" "" "" "" "" "" "" "" "" "" "" "33.9" "35.1" "36.6" "38.1" "38.5" "34.8" "31.4" "29.3" "34.2" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.000" "False" "12.598" "8" "3" "3" "3" "531" "58.9" "9.64" "10.90" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "1.024" "1.054" "1.363" "0.992" "0.998" "1.054" "0.612" "1.168" "8.211" "93.9" "96.1" "98.9" "127.9" "93.1" "93.7" "99.0" "57.4" "109.6" "770.7" "" "" "" "" "" "" "" "" "" "" "83.2" "79.6" "86.3" "95.7" "77.6" "86.1" "83.6" "47.4" "100.5" "770.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9201189030336339183" "False" "High" "IsMasterProtein" "P62875" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" "0.000" "False" "12.590" "30" "2" "3" "2" "67" "7.6" "7.77" "10.59" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01194" "5441" "ENSG00000177700" "POLR2L" "hsa:5441; P52436; P62875; Q6FHX3" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "56" "0" "0.973" "0.994" "0.887" "1.036" "1.023" "0.895" "0.931" "0.999" "1.491" "303.8" "295.7" "302.0" "269.4" "314.7" "310.9" "271.9" "282.7" "303.5" "453.0" "" "" "" "" "" "" "" "" "" "" "269.4" "244.9" "263.5" "201.5" "262.4" "285.6" "229.8" "233.7" "278.3" "453.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1068600970013118283" "False" "High" "IsMasterProtein" "Q99584" "Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1" "0.000" "False" "12.581" "29" "3" "4" "3" "98" "11.5" "6.16" "14.87" "3" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6284" "ENSG00000189171" "S100A13" "hsa:6284; Q52PI9; Q6FGF8; Q99584" "" "" "0" "0" "0.824" "0.929" "1.049" "0.985" "0.916" "1.011" "1.078" "1.171" "0.982" "102.8" "84.6" "95.4" "107.8" "101.2" "94.2" "103.9" "110.8" "120.3" "100.9" "" "" "" "" "" "" "" "" "" "" "91.1" "70.1" "83.3" "80.6" "84.4" "86.5" "87.8" "91.6" "110.4" "100.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3663346498088535534" "False" "High" "IsMasterProtein" "P0CG31" "Putative zinc finger protein 286B OS=Homo sapiens OX=9606 GN=ZNF286B PE=5 SV=1" "0.000" "False" "12.577" "5" "2" "2" "2" "522" "59.5" "8.35" "9.76" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "" "" "ZNF286B" "P0CG31" "" "" "0" "0" "1.026" "0.951" "1.001" "0.988" "0.950" "1.027" "1.009" "0.972" "0.599" "328.7" "337.3" "312.7" "328.9" "324.6" "312.2" "337.6" "331.6" "319.6" "196.9" "" "" "" "" "" "" "" "" "" "" "291.5" "279.4" "272.9" "246.0" "270.7" "286.8" "285.3" "274.1" "293.1" "196.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163626551938173047" "False" "High" "IsMasterProtein" "P27987" "Inositol-trisphosphate 3-kinase B OS=Homo sapiens OX=9606 GN=ITPKB PE=1 SV=5" "0.000" "False" "12.557" "5" "4" "5" "4" "946" "102.3" "8.43" "12.53" "4" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "3707" "ENSG00000143772" "ITPKB" "hsa:3707; P27987; Q5VWL9; Q5VWM0; Q96BZ2; Q96JS1; Q9UH47" "Synthesis of IP3 and IP4 in the cytosol" "CCL18 signaling pathway" "2" "0" "0.665" "0.662" "0.682" "0.592" "0.697" "0.680" "0.484" "0.541" "1.633" "345.5" "229.8" "228.8" "235.6" "204.6" "240.7" "235.0" "167.1" "186.8" "564.3" "" "" "" "" "" "" "" "" "" "" "306.4" "190.3" "199.7" "176.2" "170.6" "221.1" "198.6" "138.1" "171.3" "564.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294747431044223143" "False" "High" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "0.000" "False" "12.545" "2" "3" "3" "3" "1215" "131.3" "5.30" "9.34" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Transcriptional regulation by RUNX2; Late endosomal microautophagy; Cilium Assembly; Aggrephagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766745797864106974" "False" "High" "IsMasterProtein" "O75528" "Transcriptional adapter 3 OS=Homo sapiens OX=9606 GN=TADA3 PE=1 SV=1" "0.000" "False" "12.542" "6" "2" "3" "2" "432" "48.9" "6.27" "8.68" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10198" "10474" "ENSG00000171148" "TADA3" "hsa:10474; O75528; Q6FI83; Q9UFS2" "Ub-specific processing proteases; Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "3" "0" "0.965" "0.823" "0.947" "0.891" "0.860" "0.920" "0.857" "0.952" "1.768" "33.1" "31.9" "27.2" "31.3" "29.5" "28.5" "30.5" "28.3" "31.5" "58.5" "" "" "" "" "" "" "" "" "" "" "29.3" "26.5" "23.8" "23.4" "24.6" "26.1" "25.7" "23.4" "28.9" "58.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3120640487531832187" "False" "High" "IsMasterProtein" "Q9BTT4" "Mediator of RNA polymerase II transcription subunit 10 OS=Homo sapiens OX=9606 GN=MED10 PE=1 SV=1" "0.000" "False" "12.522" "28" "3" "3" "3" "135" "15.7" "6.19" "9.77" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09748" "84246" "ENSG00000133398; ENSG00000291745" "MED10" "C6G491; hsa:84246; Q9BTT4" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.482" "1.091" "0.928" "1.244" "1.070" "1.088" "1.257" "1.070" "1.020" "32.4" "48.0" "35.3" "30.1" "40.3" "34.7" "35.3" "40.7" "34.7" "33.1" "" "" "" "" "" "" "" "" "" "" "28.7" "39.8" "30.8" "22.5" "33.6" "31.8" "29.8" "33.7" "31.8" "33.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5234927014907967079" "False" "High" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "0.000" "False" "12.504" "6" "2" "2" "2" "455" "50.6" "9.10" "9.08" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.955" "0.749" "0.992" "0.921" "1.010" "0.746" "0.826" "0.739" "0.908" "72.8" "69.5" "54.5" "72.2" "67.0" "73.5" "54.3" "60.2" "53.8" "66.1" "" "" "" "" "" "" "" "" "" "" "64.6" "57.6" "47.6" "54.0" "55.9" "67.5" "45.9" "49.7" "49.3" "66.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639217336905112259" "False" "High" "IsMasterProtein" "Q8N5K1" "CDGSH iron-sulfur domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CISD2 PE=1 SV=1" "0.000" "False" "12.500" "21" "2" "3" "2" "135" "15.3" "9.61" "11.10" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf09360, Pf10660" "493856" "ENSG00000145354" "CISD2" "hsa:493856; Q7Z3D5; Q8N5K1" "" "" "0" "0" "1.101" "0.997" "1.103" "1.016" "1.033" "1.002" "1.104" "1.029" "0.829" "134.6" "148.2" "134.2" "148.4" "136.7" "139.0" "134.9" "148.5" "138.5" "111.6" "" "" "" "" "" "" "" "" "" "" "119.3" "122.8" "117.1" "111.0" "114.0" "127.7" "114.0" "122.8" "127.0" "111.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "484436176042567230" "False" "High" "IsMasterProtein" "P02686" "Myelin basic protein OS=Homo sapiens OX=9606 GN=MBP PE=1 SV=3" "0.000" "False" "12.493" "10" "1" "1" "1" "304" "33.1" "9.79" "6.69" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01669" "4155" "ENSG00000197971" "MBP" "A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4; hsa:4155; P02686; Q15337; Q15338; Q15339; Q15340; Q59GX3; Q65ZS4; Q6AI64; Q6FH37; Q6FI04; Q6PK23" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity; Opioid receptor pathways; Cell lineage map for neuronal differentiation" "10" "0" "0.806" "0.982" "0.872" "0.811" "0.900" "0.816" "0.969" "0.852" "0.388" "72.0" "58.0" "70.7" "62.8" "58.4" "64.8" "58.8" "69.8" "61.3" "27.9" "" "" "" "" "" "" "" "" "" "" "63.8" "48.0" "61.7" "46.9" "48.7" "59.5" "49.7" "57.7" "56.2" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4536625609042411990" "False" "High" "IsMasterProtein" "Q16656" "Nuclear respiratory factor 1 OS=Homo sapiens OX=9606 GN=NRF1 PE=1 SV=1" "0.000" "False" "12.488" "6" "3" "4" "3" "503" "53.5" "5.05" "12.39" "3" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf10491" "4899" "ENSG00000106459" "NRF1" "A8K4C6; B4DDV6; hsa:4899; Q15305; Q16656; Q96AN2" "PPARA activates gene expression; Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Interactions between LOXL4 and oxidative stress pathway; Mitochondrial gene expression; Sildenafil treatment" "6" "0" "1.018" "0.944" "1.064" "1.072" "0.967" "0.867" "0.834" "0.975" "1.822" "141.2" "143.7" "133.2" "150.2" "151.3" "136.6" "122.5" "117.7" "137.6" "257.1" "" "" "" "" "" "" "" "" "" "" "125.2" "119.0" "116.2" "112.4" "126.2" "125.4" "103.5" "97.3" "126.2" "257.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624211832406913783" "False" "High" "IsMasterProtein" "P15884" "Transcription factor 4 OS=Homo sapiens OX=9606 GN=TCF4 PE=1 SV=3" "0.000" "False" "12.475" "4" "2" "2" "2" "667" "71.3" "7.01" "7.19" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6925" "ENSG00000196628" "TCF4" "B3KT62; B3KUC0; B4DT37; B4DUG3; B7Z5M6; B7Z6Y1; G0LNT9; G0LNU0; G0LNU1; G0LNU2; G0LNU4; G0LNU5; G0LNU8; G0LNU9; G0LNV0; G0LNV1; G0LNV2; H3BPQ1; hsa:6925; P15884; Q08AP2; Q08AP3; Q15439; Q15440; Q15441" "Myogenesis" "Neural crest differentiation; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Development of pulmonary dendritic cells and macrophage subsets; Rett syndrome; Gastrin signaling pathway; Neurogenesis regulation in the olfactory epithelium" "10" "0" "1.150" "1.168" "1.008" "1.199" "1.054" "0.857" "0.589" "0.810" "3.484" "75.5" "86.8" "88.2" "76.1" "90.5" "79.6" "64.7" "44.5" "61.2" "263.0" "" "" "" "" "" "" "" "" "" "" "66.9" "71.9" "76.9" "56.9" "75.5" "73.1" "54.6" "36.7" "56.1" "263.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594360635056461095" "False" "High" "IsMasterProtein" "O75648" "Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2" "0.000" "False" "12.470" "15" "5" "6" "5" "421" "47.7" "8.03" "16.23" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf03054, Pf20258, Pf20259" "55687" "ENSG00000100416" "TRMU" "A8K3U7; hsa:55687; O75648; Q05C99; Q5W9C8; Q66K31; Q6ICC3; Q9NWC1" "tRNA modification in the mitochondrion" "" "1" "0" "0.959" "0.921" "0.909" "0.951" "0.860" "1.078" "1.090" "0.988" "0.957" "169.2" "162.2" "155.9" "153.7" "161.0" "145.5" "182.4" "184.4" "167.2" "161.9" "" "" "" "" "" "" "" "" "" "" "150.0" "134.4" "136.0" "115.0" "134.2" "133.6" "154.2" "152.4" "153.4" "161.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "12.469" "21" "3" "3" "3" "158" "18.7" "5.73" "11.60" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "0.951" "1.017" "1.093" "0.978" "0.956" "1.072" "1.016" "0.875" "2.703" "345.1" "328.2" "351.0" "377.3" "337.5" "329.9" "370.0" "350.5" "302.0" "932.6" "" "" "" "" "" "" "" "" "" "" "306.0" "271.9" "306.2" "282.2" "281.5" "303.1" "312.7" "289.7" "277.0" "932.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2063418146080875135" "False" "High" "IsMasterProtein" "O76094" "Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3" "0.000" "False" "12.461" "3" "2" "3" "2" "671" "74.6" "9.26" "13.12" "2" "other biological processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08492, Pf13181, Pf17004" "6731" "ENSG00000174780" "SRP72" "G5E9Z8; hsa:6731; O76094; Q7Z3C0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "0.914" "0.830" "0.880" "0.821" "0.821" "0.943" "0.577" "0.933" "4.377" "214.1" "195.7" "177.7" "188.5" "175.7" "175.7" "201.8" "123.5" "199.7" "936.9" "" "" "" "" "" "" "" "" "" "" "189.8" "162.1" "155.0" "140.9" "146.5" "161.4" "170.5" "102.0" "183.2" "936.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6936203440907421315" "False" "High" "IsMasterProtein" "Q9UEG4" "Zinc finger protein 629 OS=Homo sapiens OX=9606 GN=ZNF629 PE=1 SV=2" "0.000" "False" "12.444" "3" "3" "3" "2" "869" "96.6" "7.93" "12.81" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "23361" "ENSG00000102870" "ZNF629" "hsa:23361; Q15938; Q9UEG4" "" "" "0" "0" "0.927" "1.011" "0.887" "0.948" "0.995" "0.934" "0.934" "1.005" "1.076" "293.4" "272.0" "296.8" "260.3" "278.1" "291.8" "274.1" "273.9" "294.8" "315.6" "" "" "" "" "" "" "" "" "" "" "260.2" "225.3" "259.0" "194.6" "231.9" "268.1" "231.7" "226.4" "270.4" "315.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "12.442" "7" "3" "3" "2" "367" "41.9" "6.39" "10.62" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "30" "0" "0.943" "0.859" "0.876" "0.865" "0.800" "0.782" "0.865" "1.062" "0.931" "519.0" "489.2" "446.0" "454.4" "448.7" "415.2" "405.9" "449.1" "551.4" "483.3" "" "" "" "" "" "" "" "" "" "" "460.2" "405.3" "389.2" "339.8" "374.2" "381.4" "343.0" "371.2" "505.7" "483.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "12.433" "9" "3" "4" "3" "395" "45.3" "9.29" "14.88" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.886" "0.716" "0.838" "0.628" "0.478" "0.540" "0.670" "0.735" "1.331" "366.8" "324.8" "262.7" "307.2" "230.4" "175.2" "197.9" "245.6" "269.6" "488.2" "" "" "" "" "" "" "" "" "" "" "325.3" "269.1" "229.2" "229.8" "192.1" "161.0" "167.3" "203.0" "247.2" "488.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8640947955125983665" "False" "High" "IsMasterProtein" "Q9Y5A7" "NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2" "0.000" "False" "12.418" "9" "5" "5" "5" "615" "70.5" "5.96" "16.54" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "" "Pf00627, Pf18037" "51667" "ENSG00000013374" "NUB1" "hsa:51667; O95422; Q75MR9; Q8IX22; Q9BXR2; Q9Y5A7" "" "" "0" "0" "1.061" "1.094" "1.260" "1.232" "0.923" "1.029" "0.662" "0.927" "9.204" "126.4" "134.1" "138.2" "159.2" "155.7" "116.6" "130.1" "83.7" "117.2" "1163.4" "" "" "" "" "" "" "" "" "" "" "112.1" "111.1" "120.6" "119.1" "129.9" "107.1" "109.9" "69.2" "107.4" "1163.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4878144000314540155" "False" "High" "IsMasterProtein" "Q9NWU5" "Large ribosomal subunit protein uL22m OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" "0.000" "False" "12.403" "19" "4" "4" "4" "206" "23.6" "9.94" "14.45" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00237" "29093" "ENSG00000082515" "MRPL22" "A6NGJ8; hsa:29093; Q5H9Q1; Q96Q51; Q9NWU5; Q9P006" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.878" "0.897" "1.059" "0.789" "0.800" "1.016" "0.859" "0.915" "2.468" "161.7" "142.0" "145.1" "171.2" "127.6" "129.4" "164.3" "138.9" "148.0" "399.0" "" "" "" "" "" "" "" "" "" "" "143.4" "117.6" "126.6" "128.0" "106.4" "118.9" "138.9" "114.8" "135.7" "399.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5260823146616738925" "False" "High" "IsMasterProtein" "O43829" "Zinc finger and BTB domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZBTB14 PE=1 SV=2" "0.000" "False" "12.398" "9" "5" "6" "5" "449" "50.9" "6.04" "11.09" "5" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "7541" "ENSG00000198081" "ZBTB14" "hsa:7541; O00403; O43829; Q2TB80" "" "" "0" "0" "1.106" "1.092" "1.119" "1.284" "1.172" "0.953" "1.002" "1.107" "0.596" "63.3" "70.0" "69.1" "70.8" "81.2" "74.2" "60.3" "63.4" "70.0" "37.7" "" "" "" "" "" "" "" "" "" "" "56.1" "58.0" "60.3" "52.9" "67.7" "68.1" "50.9" "52.4" "64.2" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3757021002134428310" "False" "High" "IsMasterProtein" "Q8TBM8" "DnaJ homolog subfamily B member 14 OS=Homo sapiens OX=9606 GN=DNAJB14 PE=1 SV=1" "0.000" "False" "12.389" "5" "2" "2" "2" "379" "42.5" "8.59" "7.05" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00226, Pf09320" "79982" "ENSG00000164031" "DNAJB14" "hsa:79982; Q6UXN1; Q7Z3P0; Q86TA7; Q86TM0; Q8TBM8; Q9GZU9" "" "" "0" "0" "0.899" "0.945" "1.063" "0.888" "0.884" "0.704" "0.798" "0.843" "0.500" "284.9" "256.2" "269.3" "302.9" "253.0" "252.0" "200.7" "227.5" "240.2" "142.6" "" "" "" "" "" "" "" "" "" "" "252.7" "212.2" "235.0" "226.5" "211.0" "231.5" "169.6" "188.1" "220.3" "142.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.000" "False" "12.379" "3" "2" "2" "2" "839" "94.6" "6.77" "8.07" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "3" "0" "1.244" "0.997" "1.310" "1.175" "0.848" "1.233" "1.026" "1.073" "1.269" "54.6" "68.0" "54.5" "71.6" "64.2" "46.4" "67.3" "56.1" "58.6" "69.4" "" "" "" "" "" "" "" "" "" "" "48.5" "56.3" "47.6" "53.5" "53.6" "42.6" "56.9" "46.3" "53.8" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827826663467104318" "False" "High" "IsMasterProtein" "Q9UK41" "Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1" "0.000" "False" "12.355" "14" "3" "3" "3" "221" "25.4" "5.54" "10.13" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03997" "51160" "ENSG00000160948; ENSG00000285339" "VPS28" "hsa:51160; Q86VK0; Q9UK41" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "7q11.23 copy number variation syndrome" "6" "0" "1.171" "1.015" "1.048" "1.014" "0.940" "1.294" "0.957" "0.974" "2.309" "99.8" "116.9" "101.3" "104.6" "101.2" "93.8" "129.1" "95.5" "97.2" "230.4" "" "" "" "" "" "" "" "" "" "" "88.5" "96.8" "88.4" "78.2" "84.4" "86.2" "109.1" "78.9" "89.2" "230.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7038810457230990351" "False" "High" "IsMasterProtein" "Q8NB15" "Zinc finger protein 511 OS=Homo sapiens OX=9606 GN=ZNF511 PE=1 SV=2" "0.000" "False" "12.345" "10" "2" "3" "2" "252" "28.2" "7.66" "13.57" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "118472" "ENSG00000198546" "ZNF511" "A8K8L5; hsa:118472; Q8NB15; Q8WUP1; Q96BV2" "" "" "0" "0" "0.893" "0.941" "0.999" "0.943" "0.879" "0.931" "0.956" "0.924" "0.997" "300.1" "267.9" "282.4" "299.9" "282.9" "263.6" "279.3" "286.9" "277.4" "299.1" "" "" "" "" "" "" "" "" "" "" "266.1" "221.9" "246.4" "224.3" "235.9" "242.2" "236.1" "237.2" "254.4" "299.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726538263945454181" "False" "High" "IsMasterProtein" "Q01459" "Di-N-acetylchitobiase OS=Homo sapiens OX=9606 GN=CTBS PE=1 SV=1" "0.000" "False" "12.319" "7" "3" "3" "3" "385" "43.7" "6.64" "10.56" "3" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00704" "1486" "ENSG00000117151" "CTBS" "hsa:1486; Q01459; Q5VX50" "" "" "0" "0" "0.989" "0.979" "0.903" "0.945" "1.033" "0.887" "0.889" "0.925" "0.448" "309.6" "306.2" "303.2" "279.5" "292.6" "319.8" "274.7" "275.3" "286.4" "138.6" "" "" "" "" "" "" "" "" "" "" "274.5" "253.7" "264.6" "209.1" "244.0" "293.7" "232.1" "227.6" "262.7" "138.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1487358643357756863" "False" "High" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "0.000" "False" "12.317" "4" "2" "2" "2" "584" "64.7" "7.65" "8.55" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "0.955" "0.861" "1.019" "0.916" "1.103" "1.050" "0.142" "1.005" "17.405" "133.0" "127.0" "114.5" "135.5" "121.9" "146.8" "139.7" "18.9" "133.7" "2315.3" "" "" "" "" "" "" "" "" "" "" "118.0" "105.2" "99.9" "101.4" "101.7" "134.8" "118.1" "15.6" "122.6" "2315.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890831805190457766" "False" "High" "IsMasterProtein" "Q9BV73" "Centrosome-associated protein CEP250 OS=Homo sapiens OX=9606 GN=CEP250 PE=1 SV=2" "0.000" "False" "12.313" "1" "4" "4" "4" "2442" "281.0" "5.02" "13.09" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15035" "11190" "ENSG00000126001" "CEP250" "E1P5Q3; hsa:11190; O14812; O60588; Q9BV73; Q9H450" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Mesodermal commitment pathway" "8" "0" "1.002" "1.048" "1.017" "0.985" "0.988" "0.893" "0.589" "0.903" "3.011" "69.3" "69.5" "72.7" "70.5" "68.3" "68.5" "61.9" "40.8" "62.6" "208.8" "" "" "" "" "" "" "" "" "" "" "61.5" "57.6" "63.4" "52.8" "57.0" "62.9" "52.3" "33.7" "57.5" "208.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "High" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.000" "False" "12.304" "8" "4" "5" "4" "559" "62.0" "8.59" "16.15" "4" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "0.927" "0.979" "1.030" "1.025" "0.997" "0.939" "0.828" "0.798" "0.793" "128.2" "118.9" "125.4" "132.0" "131.3" "127.8" "120.4" "106.1" "102.3" "101.6" "" "" "" "" "" "" "" "" "" "" "113.7" "98.5" "109.4" "98.7" "109.5" "117.4" "101.7" "87.7" "93.8" "101.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851558283081104520" "False" "High" "IsMasterProtein" "Q14145" "Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2" "0.000" "False" "12.270" "7" "4" "5" "4" "624" "69.6" "6.44" "14.36" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "9817" "ENSG00000079999" "KEAP1" "B3KPD5; hsa:9817; Q14145; Q6LEP0; Q8WTX1; Q9BPY9" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Nuclear events mediated by NFE2L2" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Hereditary leiomyomatosis and renal cell carcinoma pathway; NRF2-ARE regulation; Head and neck squamous cell carcinoma; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2247702318764912013" "False" "High" "IsMasterProtein" "Q8NI22" "Multiple coagulation factor deficiency protein 2 OS=Homo sapiens OX=9606 GN=MCFD2 PE=1 SV=1" "0.000" "False" "12.259" "9" "1" "4" "1" "146" "16.4" "4.63" "8.43" "1" "transport" "other membranes;ER/Golgi" "other molecular function" "Pf13499" "90411" "ENSG00000180398" "MCFD2" "A8K7W2; D6W5A9; E9PD95; hsa:90411; Q53SS3; Q68D61; Q8N3M5; Q8NI22" "COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "" "3" "0" "1.034" "0.941" "1.354" "1.101" "0.895" "1.111" "0.940" "0.857" "0.593" "158.0" "163.4" "148.7" "213.9" "174.0" "141.4" "175.6" "148.5" "135.4" "93.8" "" "" "" "" "" "" "" "" "" "" "140.1" "135.4" "129.8" "160.0" "145.1" "129.9" "148.4" "122.7" "124.2" "93.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.000" "False" "12.243" "11" "2" "2" "2" "187" "20.8" "9.10" "6.95" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714422319878504399" "False" "High" "IsMasterProtein" "O95391" "Pre-mRNA-splicing factor SLU7 OS=Homo sapiens OX=9606 GN=SLU7 PE=1 SV=2" "0.000" "False" "12.242" "3" "2" "2" "2" "586" "68.3" "7.14" "7.73" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11708" "10569" "ENSG00000164609" "SLU7" "D3DQK2; hsa:10569; O95391; Q3LUJ0; Q3LUJ1; Q6RXQ5; Q96FM9" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "4" "0" "1.027" "0.985" "0.985" "1.012" "0.899" "0.959" "0.945" "0.967" "2.029" "112.1" "115.1" "110.3" "110.4" "113.4" "100.8" "107.5" "105.9" "108.3" "227.4" "" "" "" "" "" "" "" "" "" "" "99.4" "95.4" "96.3" "82.5" "94.5" "92.6" "90.8" "87.5" "99.3" "227.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4597913287802266182" "False" "High" "IsMasterProtein" "O60921" "Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1" "0.000" "False" "12.241" "9" "2" "3" "2" "280" "31.7" "6.84" "12.44" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04005" "3364" "ENSG00000136273" "HUS1" "B4DFI9; hsa:3364; O60921" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "ATR signaling" "8" "0" "1.144" "1.012" "1.089" "1.117" "1.159" "1.033" "1.101" "1.034" "1.048" "232.3" "265.8" "235.1" "253.0" "259.5" "269.2" "240.1" "255.9" "240.2" "243.5" "" "" "" "" "" "" "" "" "" "" "206.0" "220.2" "205.2" "189.2" "216.4" "247.3" "202.9" "211.5" "220.3" "243.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7385395348648311511" "False" "High" "IsMasterProtein" "Q9HCP0" "Casein kinase I isoform gamma-1 OS=Homo sapiens OX=9606 GN=CSNK1G1 PE=1 SV=1" "0.000" "False" "12.236" "7" "3" "3" "3" "422" "48.5" "9.01" "12.82" "3" "cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00069, Pf12605" "53944" "ENSG00000169118" "CSNK1G1" "hsa:53944; Q5JPH1; Q96AE9; Q9HCP0; Q9HCP1" "" "Wnt signaling pathway; Hedgehog signaling pathway" "2" "0" "1.184" "1.025" "1.294" "1.190" "0.925" "1.143" "1.058" "0.946" "0.572" "398.3" "471.5" "408.4" "515.6" "473.8" "368.6" "455.4" "421.5" "376.7" "228.0" "" "" "" "" "" "" "" "" "" "" "353.2" "390.6" "356.4" "385.6" "395.1" "338.6" "384.9" "348.4" "345.5" "228.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.000" "False" "12.175" "2" "4" "5" "4" "2054" "233.0" "6.30" "8.88" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "" "3" "0" "1.368" "0.917" "1.297" "0.958" "0.905" "0.892" "0.647" "1.104" "4.406" "219.2" "299.9" "201.0" "284.3" "210.0" "198.3" "195.5" "141.8" "242.0" "965.5" "" "" "" "" "" "" "" "" "" "" "194.3" "248.4" "175.3" "212.6" "175.1" "182.2" "165.3" "117.2" "221.9" "965.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1635055545262344476" "False" "High" "IsMasterProtein" "Q9UER7" "Death domain-associated protein 6 OS=Homo sapiens OX=9606 GN=DAXX PE=1 SV=2" "0.000" "False" "12.171" "5" "3" "3" "3" "740" "81.3" "4.87" "9.45" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03344, Pf20920" "1616" "ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617" "DAXX" "B4E1I3; F5ANJ6; F5ANJ7; F5H082; hsa:1616; O14747; O15141; O15208; Q5STK9; Q9BWI3; Q9UER7" "SUMOylation of transcription cofactors; HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway" "11" "0" "0.851" "1.107" "1.185" "1.256" "0.701" "0.589" "0.786" "1.177" "7.075" "39.6" "33.7" "43.8" "46.9" "49.7" "27.7" "23.3" "31.1" "46.6" "280.1" "" "" "" "" "" "" "" "" "" "" "35.1" "27.9" "38.2" "35.1" "41.5" "25.5" "19.7" "25.7" "42.7" "280.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667791429140774240" "False" "High" "IsMasterProtein" "Q9NUM4" "Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2" "0.000" "False" "12.163" "7" "2" "3" "2" "274" "31.1" "6.99" "11.02" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf07092, Pf21002" "54664" "ENSG00000106460" "TMEM106B" "A4D108; hsa:54664; Q53FL9; Q8N4L0; Q9NUM4" "" "" "0" "0" "1.020" "1.072" "1.089" "1.068" "1.201" "1.028" "1.095" "1.028" "0.530" "455.1" "464.0" "487.8" "495.5" "486.1" "546.7" "467.7" "498.1" "467.6" "241.3" "" "" "" "" "" "" "" "" "" "" "403.5" "384.4" "425.6" "370.6" "405.3" "502.2" "395.3" "411.7" "428.9" "241.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590032029601755120" "False" "High" "IsMasterProtein" "O75935" "Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1" "0.000" "False" "12.163" "23" "5" "6" "5" "186" "21.1" "5.47" "15.30" "5" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07426" "11258" "ENSG00000137100" "DCTN3" "A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "" "11" "0" "1.142" "0.912" "0.933" "0.969" "1.041" "0.992" "0.629" "1.016" "6.419" "190.9" "217.9" "174.2" "178.2" "185.0" "198.7" "189.3" "120.0" "193.9" "1225.3" "" "" "" "" "" "" "" "" "" "" "169.3" "180.5" "152.0" "133.3" "154.3" "182.6" "160.0" "99.2" "177.8" "1225.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6843403857140785601" "False" "High" "IsMasterProtein" "Q8NBL1" "Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1" "0.000" "False" "12.126" "7" "3" "3" "3" "392" "46.2" "8.72" "10.61" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf05686" "56983" "ENSG00000163389" "POGLUT1" "B2RD13; hsa:56983; Q53GJ4; Q8N2T1; Q8NBL1" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "" "1" "0" "1.033" "0.991" "1.135" "1.101" "1.027" "1.339" "1.162" "1.108" "1.459" "107.6" "111.2" "106.6" "122.1" "118.4" "110.6" "144.1" "125.1" "119.2" "157.0" "" "" "" "" "" "" "" "" "" "" "95.4" "92.1" "93.1" "91.3" "98.8" "101.6" "121.7" "103.4" "109.4" "157.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "12.084" "28" "4" "7" "4" "109" "12.4" "6.62" "17.32" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "Eukaryotic transcription initiation" "11" "0" "1.021" "1.048" "0.947" "0.935" "1.076" "0.936" "1.002" "0.927" "0.444" "860.5" "878.9" "902.1" "814.5" "804.7" "925.9" "805.7" "862.5" "797.8" "381.8" "" "" "" "" "" "" "" "" "" "" "763.0" "728.0" "787.1" "609.1" "671.0" "850.5" "680.9" "712.9" "731.7" "381.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717347442497409014" "False" "High" "IsMasterProtein" "Q9NXF7" "DDB1- and CUL4-associated factor 16 OS=Homo sapiens OX=9606 GN=DCAF16 PE=1 SV=1" "0.000" "False" "12.052" "14" "3" "3" "3" "216" "24.2" "6.04" "9.85" "3" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf15349" "54876" "ENSG00000163257" "DCAF16" "B3KPB7; hsa:54876; Q9NXF7" "Neddylation" "" "1" "0" "0.950" "0.990" "0.832" "0.911" "1.018" "0.850" "0.844" "1.013" "2.058" "247.1" "234.7" "244.7" "205.5" "225.1" "251.6" "209.9" "208.5" "250.4" "508.6" "" "" "" "" "" "" "" "" "" "" "219.1" "194.4" "213.5" "153.7" "187.7" "231.2" "177.4" "172.4" "229.6" "508.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1162437005396674229" "False" "High" "IsMasterProtein" "Q99442" "Translocation protein SEC62 OS=Homo sapiens OX=9606 GN=SEC62 PE=1 SV=1" "0.000" "False" "12.050" "8" "3" "4" "3" "399" "45.8" "7.12" "13.38" "3" "transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf03839" "7095" "ENSG00000008952" "SEC62" "D3DNQ0; hsa:7095; O00682; O00729; Q99442" "" "" "0" "0" "1.066" "0.972" "1.061" "1.035" "1.125" "0.994" "0.995" "1.098" "0.751" "413.4" "440.6" "401.8" "438.8" "427.9" "465.2" "410.8" "411.4" "454.1" "310.6" "" "" "" "" "" "" "" "" "" "" "366.6" "365.0" "350.6" "328.2" "356.8" "427.3" "347.2" "340.1" "416.4" "310.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3289873417268458662" "False" "High" "IsMasterProtein" "Q9NX40" "OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1" "0.000" "False" "12.025" "12" "3" "6" "3" "245" "27.6" "7.49" "19.44" "3" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "54940" "ENSG00000109180" "OCIAD1" "C9K030; G8JLN7; hsa:54940; Q9BZE8; Q9NX40" "" "" "0" "0" "1.014" "1.006" "0.905" "1.017" "1.108" "0.974" "0.961" "1.050" "0.694" "563.9" "571.6" "567.4" "510.3" "573.3" "624.8" "549.4" "541.7" "592.4" "391.5" "" "" "" "" "" "" "" "" "" "" "500.1" "473.5" "495.1" "381.6" "478.1" "573.9" "464.3" "447.7" "543.3" "391.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.000" "False" "12.011" "11" "4" "4" "3" "347" "35.9" "9.22" "11.00" "4" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "18" "0" "0.954" "0.834" "0.874" "0.973" "1.029" "1.006" "0.884" "0.996" "0.867" "213.2" "203.3" "177.8" "186.4" "207.5" "219.4" "214.5" "188.4" "212.3" "184.9" "" "" "" "" "" "" "" "" "" "" "189.1" "168.4" "155.1" "139.4" "173.0" "201.5" "181.3" "155.7" "194.7" "184.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4201760533929060036" "False" "High" "IsMasterProtein" "P63313" "Thymosin beta-10 OS=Homo sapiens OX=9606 GN=TMSB10 PE=1 SV=2" "0.000" "False" "11.983" "34" "3" "25" "1" "44" "5.0" "5.36" "67.28" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf01290" "9168" "ENSG00000034510" "TMSB10" "hsa:9168; P13472; P63313; Q596K9" "" "VEGFA-VEGFR2 signaling; Extrafollicular and follicular B cell activation by SARS-CoV-2" "2" "2" "0.899" "0.977" "1.016" "0.885" "0.855" "0.693" "0.962" "0.963" "0.459" "4993.6" "4488.3" "4878.2" "5071.9" "4418.0" "4267.8" "3460.9" "4805.0" "4808.0" "2293.4" "" "" "" "" "" "" "" "" "" "" "4428.2" "3717.9" "4256.4" "3793.1" "3684.0" "3920.4" "2925.0" "3971.6" "4409.6" "2293.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1643005475345734960" "False" "High" "IsMasterProtein" "Cont_A0A3Q1M032" "Uncharacterized protein OS=Bos taurus OX=9913 PE=1 SV=1" "0.000" "True" "11.972" "7" "1" "1" "1" "369" "40.4" "6.09" "6.90" "1" "" "other membranes" "" "Pf07654" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "213953215988823024" "False" "High" "IsMasterProtein" "Q92896" "Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2" "0.000" "False" "11.960" "3" "4" "4" "4" "1179" "134.5" "6.90" "11.59" "4" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytoskeleton;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00839" "2734" "ENSG00000090863" "GLG1" "B7Z8Y4; D3DUJ7; hsa:2734; Q13221; Q6P9D1; Q92896" "Cell surface interactions at the vascular wall" "" "1" "0" "0.992" "0.982" "1.051" "1.222" "1.239" "1.123" "1.166" "1.331" "0.902" "173.0" "171.5" "169.9" "181.7" "211.3" "214.3" "194.2" "201.7" "230.1" "155.9" "" "" "" "" "" "" "" "" "" "" "153.4" "142.1" "148.3" "135.9" "176.2" "196.8" "164.2" "166.7" "211.1" "155.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5200285318932313306" "False" "High" "IsMasterProtein" "Q9UHR6" "Zinc finger HIT domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZNHIT2 PE=1 SV=1" "0.000" "False" "11.947" "5" "2" "2" "2" "403" "42.9" "5.99" "7.50" "2" "" "" "other molecular function" "Pf04438" "741" "ENSG00000174276" "ZNHIT2" "hsa:741; Q3SY14; Q8IUV0; Q9UHR6" "" "" "0" "0" "0.885" "0.997" "1.208" "1.042" "1.098" "1.087" "0.010" "0.906" "18.447" "38.6" "34.2" "38.5" "46.6" "40.2" "42.4" "42.0" "0.0" "34.9" "711.8" "" "" "" "" "" "" "" "" "" "" "34.2" "28.3" "33.6" "34.8" "33.5" "38.9" "35.5" "0.0" "32.0" "711.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5515893546974733261" "False" "High" "IsMasterProtein" "E9PRG8" "Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=1 SV=2" "0.000" "False" "11.944" "17" "2" "4" "2" "123" "14.2" "11.53" "13.61" "2" "" "" "" "Pf17719" "102288414" "ENSG00000278615" "C11orf98" "A0A0B4J220; E9PRG8; hsa:102288414" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "11.937" "3" "2" "2" "2" "733" "81.7" "7.88" "9.36" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "1.000" "0.926" "1.026" "0.931" "0.893" "0.991" "0.904" "0.837" "1.316" "75.1" "75.1" "69.5" "77.1" "69.9" "67.1" "74.4" "67.9" "62.8" "98.9" "" "" "" "" "" "" "" "" "" "" "66.6" "62.2" "60.7" "57.6" "58.3" "61.6" "62.9" "56.1" "57.6" "98.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.000" "False" "11.937" "14" "3" "3" "3" "232" "25.8" "9.74" "11.20" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "tRNA processing in the nucleus" "" "1" "0" "0.841" "0.811" "0.745" "0.837" "0.807" "0.821" "0.793" "0.976" "1.745" "394.6" "331.7" "320.2" "294.0" "330.4" "318.5" "323.9" "312.7" "385.0" "688.6" "" "" "" "" "" "" "" "" "" "" "349.9" "274.8" "279.4" "219.9" "275.5" "292.6" "273.8" "258.5" "353.1" "688.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3334956500044048337" "False" "High" "IsMasterProtein" "P55197" "Protein AF-10 OS=Homo sapiens OX=9606 GN=MLLT10 PE=1 SV=2" "0.000" "False" "11.901" "3" "3" "4" "3" "1068" "113.3" "8.21" "13.49" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13831, Pf13832" "8028" "ENSG00000078403" "MLLT10" "B1ANA8; hsa:8028; P55197; Q5JT37; Q5VX90; Q66K63" "" "" "0" "0" "0.761" "0.765" "0.816" "0.781" "0.811" "0.677" "0.666" "0.709" "0.721" "287.4" "218.6" "219.8" "234.5" "224.6" "233.1" "194.7" "191.3" "203.6" "207.2" "" "" "" "" "" "" "" "" "" "" "254.9" "181.1" "191.8" "175.4" "187.3" "214.1" "164.6" "158.1" "186.8" "207.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194436757358923865" "False" "High" "IsMasterProtein" "Q5W0V3" "FHF complex subunit HOOK interacting protein 2A OS=Homo sapiens OX=9606 GN=FHIP2A PE=1 SV=1" "0.000" "False" "11.894" "4" "2" "2" "2" "765" "86.5" "5.29" "7.24" "2" "" "" "" "Pf10257, Pf19311, Pf19314" "57700" "ENSG00000151553" "FHIP2A" "Q5H9P7; Q5W0V2; Q5W0V3; Q8IY76; Q9HCH2" "" "" "0" "0" "1.096" "0.969" "1.137" "1.084" "1.013" "1.171" "1.188" "1.027" "1.050" "159.6" "174.9" "154.7" "181.4" "172.9" "161.6" "187.0" "189.6" "163.9" "167.5" "" "" "" "" "" "" "" "" "" "" "141.5" "144.8" "135.0" "135.7" "144.2" "148.5" "158.0" "156.7" "150.3" "167.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4400189645946568146" "False" "High" "IsMasterProtein" "O00488" "Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2" "0.000" "False" "11.874" "24" "2" "3" "2" "134" "15.2" "9.82" "11.16" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12171" "51042" "ENSG00000142684" "ZNF593" "B2R4S0; hsa:51042; O00488; Q5T2H7" "" "" "0" "0" "1.035" "1.126" "1.102" "1.093" "1.123" "1.179" "1.157" "1.039" "0.497" "130.7" "135.3" "147.2" "144.1" "142.9" "146.8" "154.2" "151.2" "135.8" "65.0" "" "" "" "" "" "" "" "" "" "" "115.9" "112.1" "128.5" "107.8" "119.2" "134.9" "130.3" "125.0" "124.5" "65.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5468986810261152963" "False" "High" "IsMasterProtein" "Q15334" "Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3" "0.000" "False" "11.872" "4" "4" "4" "4" "1064" "115.3" "6.29" "9.50" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf08366" "3996" "ENSG00000131899" "LLGL1" "A7MBM7; hsa:3996; O00188; Q15334; Q58F11; Q86UK6" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "1.104" "0.941" "1.009" "1.077" "1.006" "1.292" "1.086" "1.207" "2.786" "170.7" "188.5" "160.6" "172.2" "183.8" "171.7" "220.6" "185.4" "206.0" "475.7" "" "" "" "" "" "" "" "" "" "" "151.4" "156.1" "140.1" "128.8" "153.3" "157.7" "186.5" "153.2" "189.0" "475.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3902641514385650329" "False" "High" "IsMasterProtein" "Q5BKZ1" "DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2" "0.000" "False" "11.863" "4" "2" "2" "2" "582" "65.6" "5.15" "8.30" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "284695" "ENSG00000162664" "ZNF326" "A8MYX1; B4DLN0; B4E179; hsa:284695; Q5BKZ1; Q5VW93; Q5VW94; Q5VW96; Q5VW97; Q6NSA2; Q7Z638; Q7Z6C2" "" "" "0" "0" "1.013" "0.756" "1.001" "0.917" "0.798" "0.942" "0.296" "0.831" "11.052" "129.8" "131.4" "98.1" "129.9" "119.0" "103.5" "122.3" "38.4" "107.9" "1434.1" "" "" "" "" "" "" "" "" "" "" "115.1" "108.8" "85.6" "97.2" "99.2" "95.1" "103.3" "31.7" "98.9" "1434.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8876703773954477578" "False" "High" "IsMasterProtein" "O43759" "Synaptogyrin-1 OS=Homo sapiens OX=9606 GN=SYNGR1 PE=1 SV=2" "0.000" "False" "11.859" "10" "2" "2" "2" "233" "25.4" "4.68" "8.82" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01284" "9145" "ENSG00000100321" "SYNGR1" "A6NP69; A8K0E2; hsa:9145; O43757; O43758; O43759; Q53Y02; Q96J56; Q9UGZ4" "Neutrophil degranulation" "" "1" "0" "1.018" "0.970" "0.989" "1.037" "0.994" "1.002" "1.037" "0.817" "0.985" "336.4" "342.5" "326.3" "332.7" "348.9" "334.4" "336.9" "348.9" "274.9" "331.2" "" "" "" "" "" "" "" "" "" "" "298.3" "283.7" "284.7" "248.9" "291.0" "307.2" "284.8" "288.4" "252.1" "331.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782870004774892945" "False" "High" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "0.000" "False" "11.852" "7" "3" "6" "2" "467" "52.3" "6.58" "12.65" "3" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "49" "1" "1.072" "1.001" "1.101" "1.039" "0.970" "1.024" "0.835" "0.913" "3.827" "426.3" "457.2" "426.7" "469.4" "442.9" "413.5" "436.7" "356.0" "389.4" "1631.5" "" "" "" "" "" "" "" "" "" "" "378.1" "378.7" "372.4" "351.1" "369.3" "379.9" "369.1" "294.3" "357.1" "1631.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316200197019601200" "False" "High" "IsMasterProtein" "Q9Y3I1" "F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1" "0.000" "False" "11.820" "7" "3" "3" "3" "522" "58.5" "6.55" "11.46" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00646, Pf11566" "25793" "ENSG00000100225" "FBXO7" "B4DNB3; B4DWX5; hsa:25793; Q5TGC4; Q5TI86; Q96HM6; Q9UF21; Q9UKT2; Q9Y3I1" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.033" "0.960" "1.017" "1.053" "1.006" "1.092" "0.987" "0.940" "1.764" "374.4" "386.6" "359.6" "380.9" "394.1" "376.6" "408.9" "369.6" "352.1" "660.5" "" "" "" "" "" "" "" "" "" "" "332.0" "320.3" "313.7" "284.9" "328.6" "346.0" "345.5" "305.5" "322.9" "660.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8378095313839820512" "False" "High" "IsMasterProtein" "P15923" "Transcription factor E2-alpha OS=Homo sapiens OX=9606 GN=TCF3 PE=1 SV=1" "0.000" "False" "11.786" "4" "2" "2" "2" "654" "67.6" "6.47" "7.79" "2" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6929" "ENSG00000071564" "TCF3" "hsa:6929; P15883; P15923; Q14208; Q14635; Q14636; Q2TB39; Q2TB40; Q9UPI9" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis" "Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; lncRNA in canonical Wnt signaling and colorectal cancer; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2215661484008569262" "False" "High" "IsMasterProtein" "Q9UBW7" "Zinc finger MYM-type protein 2 OS=Homo sapiens OX=9606 GN=ZMYM2 PE=1 SV=1" "0.000" "False" "11.771" "2" "3" "3" "3" "1377" "154.8" "6.34" "8.88" "3" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf06467, Pf12012" "7750" "ENSG00000121741" "ZMYM2" "A6NDG0; A6NI02; hsa:7750; O43212; O43434; O60898; Q5W0Q4; Q5W0T3; Q63HP0; Q8NE39; Q9H0V5; Q9H538; Q9UBW7; Q9UEU2" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "" "3" "0" "1.185" "1.044" "0.954" "0.984" "1.074" "0.993" "0.459" "1.096" "14.554" "105.9" "125.5" "110.5" "101.0" "104.2" "113.8" "105.1" "48.6" "116.1" "1541.6" "" "" "" "" "" "" "" "" "" "" "93.9" "104.0" "96.4" "75.5" "86.9" "104.5" "88.9" "40.2" "106.4" "1541.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-737330374784277396" "False" "High" "IsMasterProtein" "Q6ZV73" "FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens OX=9606 GN=FGD6 PE=1 SV=2" "0.000" "False" "11.750" "2" "3" "3" "3" "1430" "160.7" "7.03" "10.83" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "55785" "ENSG00000180263" "FGD6" "hsa:55785; Q6ZR53; Q6ZV73; Q7Z2Z7; Q96D44; Q9NUR8; Q9P2I5" "" "" "0" "0" "1.130" "1.226" "1.083" "0.942" "1.082" "0.785" "0.809" "0.827" "1.618" "99.1" "112.0" "121.5" "107.4" "93.4" "107.2" "77.8" "80.2" "82.0" "160.4" "" "" "" "" "" "" "" "" "" "" "87.9" "92.8" "106.0" "80.3" "77.9" "98.5" "65.8" "66.3" "75.2" "160.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-161088924712109766" "False" "High" "IsMasterProtein" "Q96RU2" "Ubiquitin carboxyl-terminal hydrolase 28 OS=Homo sapiens OX=9606 GN=USP28 PE=1 SV=1" "0.000" "False" "11.721" "3" "3" "3" "3" "1077" "122.4" "5.20" "10.86" "3" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57646" "ENSG00000048028" "USP28" "B0YJC0; B0YJC1; hsa:57646; Q6NZX9; Q96RU2; Q9P213" "Ub-specific processing proteases" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "2" "0" "1.624" "0.884" "1.030" "1.155" "1.071" "1.118" "0.579" "1.114" "7.608" "75.4" "122.5" "66.7" "77.7" "87.1" "80.8" "84.3" "43.6" "84.0" "573.8" "" "" "" "" "" "" "" "" "" "" "66.9" "101.4" "58.2" "58.1" "72.7" "74.2" "71.2" "36.1" "77.0" "573.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5274992111862833065" "False" "High" "IsMasterProtein" "Q8IXJ6" "NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2" "0.000" "False" "11.711" "7" "3" "3" "3" "389" "43.2" "5.36" "10.33" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02146" "22933" "ENSG00000068903; ENSG00000283100" "SIRT2" "A8K3V1; B2RB45; hsa:22933; O95889; Q8IXJ6; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13" "Initiation of Nuclear Envelope (NE) Reformation" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; HDAC6 interactions in the central nervous system" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1899154642705730358" "False" "High" "IsMasterProtein" "Q9UNK0" "Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2" "0.000" "False" "11.702" "11" "3" "3" "3" "236" "26.9" "4.98" "10.48" "3" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739" "9482" "ENSG00000170310" "STX8" "hsa:9482; O60712; Q53XT8; Q9UNK0" "" "" "0" "0" "1.112" "1.002" "1.260" "1.093" "0.896" "1.187" "1.004" "1.016" "0.689" "636.4" "707.8" "637.5" "802.0" "695.6" "570.2" "755.3" "639.0" "646.5" "438.6" "" "" "" "" "" "" "" "" "" "" "564.3" "586.3" "556.3" "599.8" "580.1" "523.8" "638.3" "528.2" "593.0" "438.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "11.699" "46" "4" "6" "4" "68" "7.7" "8.18" "19.31" "4" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "Mitochondrial protein import" "" "1" "0" "1.010" "0.980" "0.921" "0.960" "1.083" "0.944" "1.011" "1.010" "0.571" "1049.9" "1060.3" "1029.0" "966.6" "1007.5" "1137.0" "990.7" "1061.2" "1060.1" "599.9" "" "" "" "" "" "" "" "" "" "" "931.0" "878.3" "897.8" "722.9" "840.1" "1044.4" "837.3" "877.2" "972.2" "599.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1790933947294059226" "False" "High" "IsMasterProtein" "Q9H477" "Ribokinase OS=Homo sapiens OX=9606 GN=RBKS PE=1 SV=1" "0.000" "False" "11.687" "9" "3" "4" "3" "322" "34.1" "5.05" "14.41" "3" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "64080" "ENSG00000171174" "RBKS" "A9UK04; B4DV96; hsa:64080; Q9H477" "Pentose phosphate pathway" "" "1" "0" "1.006" "0.986" "0.969" "1.053" "1.023" "0.983" "0.988" "0.918" "0.451" "440.9" "443.7" "434.6" "427.5" "464.3" "451.1" "433.6" "435.8" "404.6" "199.0" "" "" "" "" "" "" "" "" "" "" "391.0" "367.6" "379.2" "319.7" "387.2" "414.4" "366.5" "360.2" "371.1" "199.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2268308097842944024" "False" "High" "IsMasterProtein" "Q9NPL8" "Complex I assembly factor TIMMDC1, mitochondrial OS=Homo sapiens OX=9606 GN=TIMMDC1 PE=1 SV=2" "0.000" "False" "11.674" "11" "3" "3" "3" "285" "32.2" "8.50" "11.40" "3" "" "other membranes;mitochondrion;nucleus" "" "Pf02466" "51300" "ENSG00000113845" "TIMMDC1" "D3DN81; hsa:51300; Q6IAJ7; Q6UWU6; Q9NPL8; Q9NPR3; Q9NPS5; Q9P0Y6" "Complex I biogenesis" "" "1" "0" "0.961" "0.936" "0.979" "0.904" "0.994" "0.960" "0.952" "0.960" "0.411" "486.9" "467.8" "455.7" "476.6" "440.0" "483.8" "467.6" "463.6" "467.5" "200.3" "" "" "" "" "" "" "" "" "" "" "431.8" "387.5" "397.6" "356.4" "366.9" "444.4" "395.2" "383.2" "428.8" "200.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157929292758815644" "False" "High" "IsMasterProtein" "Q96A35" "Large ribosomal subunit protein uL24m OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "0.000" "False" "11.670" "14" "3" "4" "3" "216" "24.9" "9.29" "12.74" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.974" "0.934" "0.902" "0.910" "0.814" "1.160" "0.971" "0.964" "2.367" "103.2" "100.5" "96.4" "93.1" "93.9" "84.0" "119.7" "100.2" "99.5" "244.3" "" "" "" "" "" "" "" "" "" "" "91.5" "83.3" "84.2" "69.6" "78.3" "77.1" "101.2" "82.8" "91.3" "244.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857902194460077614" "False" "High" "IsMasterProtein" "Q13535" "Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3" "0.000" "False" "11.665" "1" "5" "5" "4" "2644" "301.2" "7.43" "14.30" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08064" "545" "ENSG00000175054" "ATR" "hsa:545; Q13535; Q59HB2; Q7KYL3; Q93051; Q9BXK4" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; Cell cycle; ATR signaling; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; NIPBL role in DNA damage - Cornelia de Lange syndrome; DNA damage response" "19" "0" "0.796" "0.794" "0.871" "0.771" "0.865" "0.830" "0.882" "0.859" "1.362" "668.5" "532.1" "531.0" "582.1" "515.3" "578.4" "555.1" "589.5" "574.3" "910.7" "" "" "" "" "" "" "" "" "" "" "592.9" "440.7" "463.3" "435.3" "429.7" "531.4" "469.2" "487.3" "526.8" "910.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889499803111270787" "False" "High" "IsMasterProtein" "O43824" "Putative GTP-binding protein 6 OS=Homo sapiens OX=9606 GN=GTPBP6 PE=1 SV=4" "0.000" "False" "11.660" "8" "3" "3" "3" "516" "56.9" "9.42" "10.85" "3" "" "other cell component" "translation activity;other molecular function" "Pf01926, Pf13167, Pf16360" "8225" "ENSG00000178605; ENSG00000292358" "GTPBP6" "H0Y2S1; hsa:8225; O43824; Q53F77; Q5HYX8" "" "" "0" "0" "1.303" "1.016" "1.480" "1.120" "0.919" "1.377" "1.063" "1.113" "0.776" "46.4" "60.4" "47.1" "68.7" "51.9" "42.6" "63.9" "49.3" "51.6" "36.0" "" "" "" "" "" "" "" "" "" "" "41.1" "50.0" "41.1" "51.3" "43.3" "39.2" "54.0" "40.7" "47.3" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2333660704476735765" "False" "High" "IsMasterProtein" "O15397" "Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2" "0.000" "False" "11.655" "3" "3" "3" "3" "1037" "119.9" "5.16" "10.67" "3" "transport;signal transduction" "cytosol;nucleus" "other molecular function" "Pf03810, Pf08506" "10526" "ENSG00000133704" "IPO8" "B7Z7M3; hsa:10526; O15397" "Transcriptional regulation by small RNAs" "Autophagy in pancreatic ductal adenocarcinoma" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7089722272324942505" "False" "High" "IsMasterProtein" "Q9NU23" "LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1" "0.000" "False" "11.639" "39" "4" "5" "4" "88" "10.4" "10.46" "15.78" "4" "cell organization and biogenesis" "mitochondrion" "" "Pf05347" "57226" "ENSG00000083099" "LYRM2" "B2R4U2; E1P517; hsa:57226; Q9NU23" "" "" "0" "0" "1.082" "1.019" "1.060" "1.033" "1.033" "1.047" "1.098" "0.965" "0.392" "303.9" "328.9" "309.7" "322.2" "314.0" "314.0" "318.1" "333.6" "293.1" "119.1" "" "" "" "" "" "" "" "" "" "" "269.5" "272.4" "270.2" "240.9" "261.9" "288.4" "268.9" "275.7" "268.8" "119.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2095194651549531862" "False" "High" "IsMasterProtein" "O95487" "Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2" "0.000" "False" "11.621" "2" "2" "2" "2" "1268" "137.3" "6.67" "7.92" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10427" "ENSG00000138802" "SEC24B" "B7ZKM8; B7ZKN4; hsa:10427; O95487; Q0VG08" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.014" "0.864" "1.348" "1.156" "0.857" "1.166" "1.004" "0.756" "2.207" "64.4" "65.3" "55.6" "86.8" "74.4" "55.2" "75.1" "64.6" "48.7" "142.1" "" "" "" "" "" "" "" "" "" "" "57.1" "54.1" "48.5" "64.9" "62.0" "50.7" "63.4" "53.4" "44.6" "142.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2007985770655079458" "False" "High" "IsMasterProtein" "Q9BPX6" "Calcium uptake protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MICU1 PE=1 SV=1" "0.000" "False" "11.602" "11" "5" "5" "5" "476" "54.3" "8.41" "13.72" "5" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13202" "10367" "ENSG00000107745" "MICU1" "A8MV96; B3KN20; B4DJH9; B4DPI1; B5MBY3; D3YTJ3; hsa:10367; O75785; Q9BPX6; Q9H9N6; Q9UFX0" "Processing of SMDT1" "" "2" "0" "0.916" "1.046" "0.960" "1.013" "1.090" "1.041" "1.088" "1.050" "0.938" "308.9" "283.1" "323.0" "296.5" "313.0" "336.8" "321.6" "336.2" "324.4" "289.7" "" "" "" "" "" "" "" "" "" "" "273.9" "234.5" "281.8" "221.7" "261.0" "309.4" "271.8" "277.9" "297.5" "289.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8789508812130398643" "False" "High" "IsMasterProtein" "Q9BTE7" "DCN1-like protein 5 OS=Homo sapiens OX=9606 GN=DCUN1D5 PE=1 SV=1" "0.000" "False" "11.599" "14" "3" "3" "3" "237" "27.5" "5.58" "7.25" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03556" "84259" "ENSG00000137692" "DCUN1D5" "hsa:84259; Q3ZTT2; Q9BTE7" "Neddylation" "" "1" "0" "1.129" "0.875" "1.147" "1.073" "0.954" "1.075" "0.825" "0.948" "3.189" "245.6" "277.2" "214.9" "281.6" "263.4" "234.2" "263.9" "202.5" "232.8" "783.0" "" "" "" "" "" "" "" "" "" "" "217.7" "229.6" "187.6" "210.6" "219.6" "215.2" "223.0" "167.4" "213.5" "783.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020211284576112703" "False" "High" "IsMasterProtein" "Q86UY8" "5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1" "0.000" "False" "11.587" "7" "3" "3" "3" "548" "63.4" "8.31" "6.77" "3" "" "cytosol;other cell component" "other molecular function" "Pf05761" "51559" "ENSG00000111696" "NT5DC3" "hsa:51559; Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3" "" "" "0" "0" "0.850" "0.874" "0.906" "0.828" "0.768" "1.067" "0.866" "0.845" "0.525" "43.0" "36.6" "37.6" "39.0" "35.6" "33.0" "45.9" "37.3" "36.3" "22.6" "" "" "" "" "" "" "" "" "" "" "38.1" "30.3" "32.8" "29.2" "29.7" "30.4" "38.8" "30.8" "33.3" "22.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2490332894624900384" "False" "High" "IsMasterProtein" "Q92574" "Hamartin OS=Homo sapiens OX=9606 GN=TSC1 PE=1 SV=2" "0.000" "False" "11.573" "4" "5" "5" "5" "1164" "129.7" "6.47" "11.43" "5" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04388" "7248" "ENSG00000165699" "TSC1" "B7Z897; hsa:7248; Q5VVN5; Q92574" "TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "27" "0" "0.830" "0.823" "0.886" "0.866" "0.826" "0.922" "0.620" "0.957" "4.513" "284.6" "236.2" "234.3" "252.1" "246.6" "235.1" "262.3" "176.5" "272.5" "1284.5" "" "" "" "" "" "" "" "" "" "" "252.4" "195.6" "204.5" "188.5" "205.6" "216.0" "221.7" "145.9" "249.9" "1284.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "11.573" "9" "3" "4" "3" "316" "34.8" "8.35" "14.59" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "1.022" "1.004" "1.079" "1.117" "0.884" "1.048" "0.807" "0.941" "5.070" "173.5" "177.4" "174.1" "187.1" "193.8" "153.4" "181.9" "140.0" "163.4" "879.7" "" "" "" "" "" "" "" "" "" "" "153.9" "146.9" "152.0" "140.0" "161.6" "140.9" "153.7" "115.7" "149.8" "879.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1699378345202944964" "False" "High" "IsMasterProtein" "Q96MX6" "Dynein axonemal assembly factor 10 OS=Homo sapiens OX=9606 GN=DNAAF10 PE=1 SV=1" "0.000" "False" "11.561" "8" "3" "3" "3" "357" "39.7" "8.09" "9.80" "3" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "1.034" "0.999" "1.005" "1.052" "1.054" "1.003" "1.075" "0.998" "1.704" "345.7" "357.3" "345.2" "347.6" "363.6" "364.3" "346.7" "371.6" "344.9" "588.9" "" "" "" "" "" "" "" "" "" "" "306.5" "295.9" "301.2" "259.9" "303.2" "334.7" "293.1" "307.2" "316.4" "588.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-425292061037693979" "False" "High" "IsMasterProtein" "Q9HBR0" "Solute carrier family 38 member 10 OS=Homo sapiens OX=9606 GN=SLC38A10 PE=1 SV=2" "0.000" "False" "11.559" "3" "3" "4" "3" "1119" "119.7" "5.73" "12.39" "3" "transport;developmental processes" "other membranes;ER/Golgi" "transporter activity" "Pf01490" "124565" "ENSG00000157637" "SLC38A10" "hsa:124565; Q6ZRC5; Q8NA99; Q96C66; Q9HBR0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2126851971965856372" "False" "High" "IsMasterProtein" "Q9BSU1" "Phagosome assembly factor 1 OS=Homo sapiens OX=9606 GN=PHAF1 PE=1 SV=1" "0.000" "False" "11.546" "6" "2" "2" "2" "422" "47.5" "7.72" "8.20" "2" "transport" "other membranes;ER/Golgi;other cell component" "" "Pf03676" "80262" "ENSG00000125149" "PHAF1" "hsa:80262; Q9BSU1; Q9HA86" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "11.521" "17" "3" "4" "3" "157" "18.2" "7.59" "14.02" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "Transcriptional Regulation by E2F6" "" "1" "0" "0.970" "0.810" "0.822" "0.772" "0.709" "0.674" "0.713" "0.829" "1.050" "791.8" "768.0" "641.7" "650.5" "611.1" "561.4" "534.0" "564.3" "656.1" "831.8" "" "" "" "" "" "" "" "" "" "" "702.2" "636.2" "559.9" "486.5" "509.5" "515.8" "451.3" "466.5" "601.7" "831.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8911180821409162451" "False" "High" "IsMasterProtein" "Q9NYB9" "Abl interactor 2 OS=Homo sapiens OX=9606 GN=ABI2 PE=1 SV=1" "0.000" "False" "11.520" "7" "3" "5" "1" "513" "55.6" "6.16" "11.15" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00018, Pf07815" "10152" "ENSG00000138443" "ABI2" "B4DSN1; hsa:10152; Q13147; Q13249; Q13801; Q9BV70; Q9NYB9" "RAC1 GTPase cycle; RAC2 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Regulation of actin cytoskeleton" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2713677220638239159" "False" "High" "IsMasterProtein" "Q7L099" "Protein RUFY3 OS=Homo sapiens OX=9606 GN=RUFY3 PE=1 SV=1" "0.000" "False" "11.517" "6" "3" "3" "2" "469" "52.9" "5.49" "10.60" "3" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cell component" "" "Pf02759" "22902" "ENSG00000018189" "RUFY3" "B3KM25; B4DYW7; D9N163; hsa:22902; O94948; Q7L099; Q9UI00" "" "" "0" "0" "0.927" "0.965" "1.033" "0.922" "0.876" "0.826" "0.736" "0.911" "3.374" "208.6" "193.3" "201.2" "215.5" "192.3" "182.7" "172.3" "153.6" "190.0" "703.9" "" "" "" "" "" "" "" "" "" "" "185.0" "160.1" "175.6" "161.1" "160.4" "167.8" "145.7" "127.0" "174.2" "703.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5412542927183305238" "False" "High" "IsMasterProtein" "P17535" "Transcription factor JunD OS=Homo sapiens OX=9606 GN=JUND PE=1 SV=3" "0.000" "False" "11.514" "6" "2" "2" "1" "347" "35.2" "7.37" "7.93" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3727" "ENSG00000130522" "JUND" "hsa:3727; P17535; Q53EK9" "NGF-stimulated transcription; Estrogen-dependent gene expression" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; Angiotensin II receptor type 1 pathway; Hypertrophy model; 10q11.21q11.23 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "14" "0" "1.133" "1.111" "1.270" "1.127" "0.864" "1.459" "1.441" "1.331" "0.885" "55.4" "62.7" "61.5" "70.3" "62.4" "47.9" "80.8" "79.8" "73.7" "49.0" "" "" "" "" "" "" "" "" "" "" "49.1" "52.0" "53.7" "52.6" "52.0" "44.0" "68.3" "65.9" "67.6" "49.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3106381619938843905" "False" "High" "IsMasterProtein" "Q5TA31" "E3 ubiquitin-protein ligase RNF187 OS=Homo sapiens OX=9606 GN=RNF187 PE=1 SV=2" "0.000" "False" "11.486" "16" "3" "3" "3" "235" "26.2" "5.95" "11.34" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15227" "149603" "ENSG00000168159; ENSG00000285426" "RNF187" "A6NL57; hsa:149603; Q5TA31; Q6P2J7; Q6PJR0" "" "" "0" "0" "1.075" "1.030" "1.229" "1.100" "1.078" "1.069" "1.005" "1.045" "0.615" "152.1" "163.4" "156.6" "187.0" "167.3" "163.9" "162.5" "152.9" "158.9" "93.5" "" "" "" "" "" "" "" "" "" "" "134.9" "135.4" "136.7" "139.8" "139.5" "150.6" "137.4" "126.4" "145.7" "93.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2535135395164112803" "False" "High" "IsMasterProtein" "Q96KM6" "Zinc finger protein 512B OS=Homo sapiens OX=9606 GN=ZNF512B PE=1 SV=1" "0.000" "False" "11.470" "4" "3" "3" "3" "892" "97.2" "9.83" "10.93" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf21276" "57473" "ENSG00000196700" "ZNF512B" "hsa:57473; Q08AK9; Q96KM6; Q9ULM4" "RHOV GTPase cycle" "" "1" "0" "1.029" "0.915" "0.927" "0.921" "0.858" "0.923" "0.938" "0.940" "0.688" "201.6" "207.4" "184.4" "186.9" "185.6" "172.9" "186.1" "189.0" "189.6" "138.7" "" "" "" "" "" "" "" "" "" "" "178.8" "171.8" "160.9" "139.8" "154.8" "158.8" "157.3" "156.2" "173.9" "138.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "High" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.000" "False" "11.446" "9" "4" "5" "4" "424" "48.0" "6.29" "15.58" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "Metalloprotease DUBs" "EGF/EGFR signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5985118232380264359" "False" "High" "IsMasterProtein" "Q15363" "Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1" "0.000" "False" "11.439" "10" "2" "4" "2" "201" "22.7" "5.17" "9.69" "2" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf01105" "10959" "ENSG00000086598" "TMED2" "hsa:10959; Q15363" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Pre-NOTCH Processing in Golgi; COPII-mediated vesicle transport; Cargo concentration in the ER" "5q35 copy number variation" "6" "0" "1.210" "0.876" "1.026" "1.138" "1.055" "0.971" "0.912" "1.208" "1.808" "201.5" "243.9" "176.5" "206.7" "229.3" "212.7" "195.7" "183.9" "243.4" "364.3" "" "" "" "" "" "" "" "" "" "" "178.7" "202.1" "154.0" "154.6" "191.2" "195.4" "165.4" "152.0" "223.2" "364.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2935309689569447405" "False" "High" "IsMasterProtein" "Q9BYD6" "Large ribosomal subunit protein uL1m OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" "0.000" "False" "11.439" "8" "3" "4" "3" "325" "36.9" "8.78" "14.90" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00687" "65008" "ENSG00000169288" "MRPL1" "A6NG03; hsa:65008; Q4W5B8; Q6IAG4; Q96BW3; Q9BYD6; Q9H793; Q9NRL5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.159" "1.071" "1.144" "1.162" "1.682" "1.268" "0.840" "1.398" "8.258" "385.8" "447.0" "413.4" "441.4" "448.4" "648.8" "489.1" "324.1" "539.5" "3186.3" "" "" "" "" "" "" "" "" "" "" "342.2" "370.3" "360.7" "330.1" "373.9" "596.0" "413.4" "267.9" "494.8" "3186.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8858852225098701208" "False" "High" "IsMasterProtein" "P49642" "DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1" "0.000" "False" "11.431" "7" "3" "3" "3" "420" "49.9" "8.21" "8.77" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01896" "5557" "ENSG00000198056" "PRIM1" "hsa:5557; P49642" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "13" "0" "1.033" "1.047" "1.075" "0.783" "0.881" "1.205" "0.408" "0.891" "10.425" "27.3" "28.2" "28.6" "29.4" "21.4" "24.1" "32.9" "11.1" "24.3" "284.8" "" "" "" "" "" "" "" "" "" "" "24.2" "23.4" "24.9" "22.0" "17.8" "22.1" "27.8" "9.2" "22.3" "284.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5117695276373963239" "False" "High" "IsMasterProtein" "Q9UKL0" "REST corepressor 1 OS=Homo sapiens OX=9606 GN=RCOR1 PE=1 SV=2" "0.000" "False" "11.407" "8" "5" "5" "2" "485" "53.3" "7.03" "12.30" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "23186" "ENSG00000089902" "RCOR1" "hsa:23186; J3KN32; Q15044; Q6P2I9; Q86VG5; Q9UKL0" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; Factors involved in megakaryocyte development and platelet production; HDACs deacetylate histones" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.000" "False" "11.400" "6" "2" "2" "2" "325" "35.7" "4.74" "9.25" "2" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "1.022" "0.907" "0.967" "0.925" "0.950" "0.986" "0.684" "0.971" "3.454" "175.5" "179.3" "159.2" "169.6" "162.4" "166.7" "173.1" "120.1" "170.4" "606.3" "" "" "" "" "" "" "" "" "" "" "155.6" "148.5" "138.9" "126.9" "135.4" "153.1" "146.3" "99.2" "156.3" "606.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687801448742430149" "False" "High" "IsMasterProtein" "Q9H4A6" "Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1" "0.000" "False" "11.398" "13" "4" "4" "4" "298" "33.8" "6.44" "9.98" "4" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05719" "64083" "ENSG00000113384" "GOLPH3" "hsa:64083; Q9H4A6; Q9UIW5" "" "" "0" "0" "0.857" "0.756" "0.753" "0.706" "0.721" "0.599" "0.583" "0.732" "1.485" "512.2" "439.1" "387.4" "385.8" "361.6" "369.3" "307.1" "298.5" "375.0" "760.5" "" "" "" "" "" "" "" "" "" "" "454.2" "363.7" "338.0" "288.5" "301.5" "339.3" "259.5" "246.7" "343.9" "760.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4959898328745925415" "False" "High" "IsMasterProtein" "Q6IN84" "rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1" "0.000" "False" "11.363" "11" "4" "4" "4" "353" "38.6" "7.94" "9.72" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588, Pf08032" "79922" "ENSG00000274853; ENSG00000278619" "MRM1" "A8K8E2; hsa:79922; Q6IN84; Q96GK2; Q9H664" "rRNA modification in the mitochondrion" "17q12 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7030839673765711891" "False" "High" "IsMasterProtein" "Q9HC44" "Vasculin-like protein 1 OS=Homo sapiens OX=9606 GN=GPBP1L1 PE=1 SV=1" "0.000" "False" "11.344" "11" "3" "3" "3" "474" "52.3" "6.84" "7.96" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf15337" "60313" "ENSG00000159592" "GPBP1L1" "D3DQ10; hsa:60313; Q9H751; Q9HC44" "" "" "0" "0" "1.054" "1.047" "1.181" "1.249" "1.129" "1.243" "1.415" "1.236" "0.869" "224.8" "237.0" "235.3" "265.5" "280.9" "253.8" "279.4" "318.1" "277.8" "195.3" "" "" "" "" "" "" "" "" "" "" "199.3" "196.3" "205.3" "198.6" "234.2" "233.1" "236.1" "263.0" "254.8" "195.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.000" "False" "11.328" "5" "4" "5" "4" "804" "91.8" "7.42" "13.72" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.049" "0.864" "1.086" "0.956" "1.006" "1.008" "0.875" "0.779" "1.974" "566.0" "593.7" "488.9" "614.5" "541.3" "569.2" "570.4" "495.4" "440.8" "1117.3" "" "" "" "" "" "" "" "" "" "" "501.9" "491.8" "426.5" "459.6" "451.3" "522.8" "482.0" "409.5" "404.2" "1117.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5042642415102067907" "False" "High" "IsMasterProtein" "Q99549" "M-phase phosphoprotein 8 OS=Homo sapiens OX=9606 GN=MPHOSPH8 PE=1 SV=2" "0.000" "False" "11.326" "3" "2" "2" "2" "860" "97.1" "6.06" "8.40" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00385, Pf12796" "54737" "ENSG00000196199" "MPHOSPH8" "B7Z6F9; hsa:54737; Q5JPE5; Q5JTQ0; Q86TK3; Q96MK4; Q99549; Q9BTP1" "" "" "0" "0" "1.470" "0.958" "1.200" "1.005" "0.979" "1.165" "0.897" "0.892" "0.818" "124.2" "182.7" "119.0" "149.1" "124.9" "121.6" "144.7" "111.4" "110.9" "101.6" "" "" "" "" "" "" "" "" "" "" "110.2" "151.3" "103.8" "111.5" "104.1" "111.7" "122.3" "92.1" "101.7" "101.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6478965972270282031" "False" "High" "IsMasterProtein" "Q9H246" "Uncharacterized protein C1orf21 OS=Homo sapiens OX=9606 GN=C1orf21 PE=1 SV=1" "0.000" "False" "11.317" "27" "3" "3" "3" "121" "13.9" "5.22" "8.60" "3" "" "" "" "Pf15389" "81563" "ENSG00000116667" "C1orf21" "B2R551; Q9H246" "" "" "0" "0" "0.929" "0.882" "1.044" "0.968" "0.893" "1.032" "0.874" "0.894" "0.448" "345.6" "321.1" "304.8" "360.9" "334.7" "308.6" "356.6" "302.1" "308.8" "154.7" "" "" "" "" "" "" "" "" "" "" "306.5" "266.0" "266.0" "269.9" "279.1" "283.5" "301.4" "249.7" "283.2" "154.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "282539810863181563" "False" "High" "IsMasterProtein" "Q9UL40" "Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1" "0.000" "False" "11.289" "11" "3" "3" "3" "294" "32.9" "9.09" "9.22" "3" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "23567" "ENSG00000113761" "ZNF346" "B7Z367; hsa:23567; Q68CV9; Q6ZMW1; Q9UL40" "" "5q35 copy number variation" "1" "0" "1.015" "0.975" "1.060" "1.109" "0.915" "1.090" "1.112" "0.888" "0.934" "236.0" "239.5" "230.2" "250.3" "261.7" "215.9" "257.4" "262.4" "209.5" "220.5" "" "" "" "" "" "" "" "" "" "" "209.3" "198.4" "200.9" "187.2" "218.2" "198.3" "217.5" "216.9" "192.2" "220.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1962544655148758053" "False" "High" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "0.000" "False" "11.274" "4" "3" "4" "3" "595" "69.6" "6.47" "13.80" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "10" "0" "0.893" "0.917" "0.985" "1.028" "0.966" "0.981" "0.985" "0.843" "0.964" "341.4" "304.8" "312.9" "336.2" "351.0" "329.7" "334.7" "336.1" "287.7" "329.2" "" "" "" "" "" "" "" "" "" "" "302.7" "252.5" "273.0" "251.4" "292.7" "302.8" "282.9" "277.8" "263.8" "329.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.000" "False" "11.272" "15" "3" "3" "3" "176" "20.7" "6.34" "10.26" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "" "2" "0" "0.952" "0.958" "0.941" "0.911" "0.976" "0.948" "0.930" "0.821" "0.848" "221.3" "210.7" "212.0" "208.2" "201.5" "216.0" "209.7" "205.9" "181.6" "187.7" "" "" "" "" "" "" "" "" "" "" "196.3" "174.5" "185.0" "155.7" "168.1" "198.4" "177.2" "170.2" "166.6" "187.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8296927392794764826" "False" "High" "IsMasterProtein" "Q9BZL4" "Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1" "0.000" "False" "11.270" "3" "2" "2" "2" "782" "84.8" "5.57" "8.36" "2" "signal transduction" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf12796, Pf15898" "54776" "ENSG00000125503" "PPP1R12C" "B4DME2; hsa:54776; Q59FK8; Q6ZPD1; Q7L8F7; Q96HW1; Q9BZL4; Q9H5H5; Q9NT00" "" "Focal adhesion" "1" "0" "1.065" "0.942" "1.009" "0.894" "0.905" "1.008" "0.724" "0.960" "2.267" "91.8" "97.7" "86.4" "92.6" "82.0" "83.0" "92.5" "66.4" "88.1" "208.0" "" "" "" "" "" "" "" "" "" "" "81.4" "81.0" "75.4" "69.3" "68.4" "76.3" "78.2" "54.9" "80.8" "208.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5378807455886263528" "False" "High" "IsMasterProtein" "Q13740" "CD166 antigen OS=Homo sapiens OX=9606 GN=ALCAM PE=1 SV=2" "0.000" "False" "11.268" "7" "3" "3" "3" "583" "65.1" "6.25" "10.65" "3" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08205, Pf13927" "214" "ENSG00000170017" "ALCAM" "B2RNS3; B4DTU0; hsa:214; O60892; Q13740; Q1HGM8; Q1HGM9; Q6PEY4; Q6ZS95" "L1CAM interactions" "" "1" "0" "1.103" "1.037" "0.990" "1.010" "1.052" "0.966" "1.079" "1.177" "0.726" "322.0" "355.0" "334.0" "318.6" "325.2" "338.8" "311.0" "347.5" "378.9" "233.8" "" "" "" "" "" "" "" "" "" "" "285.5" "294.0" "291.4" "238.3" "271.1" "311.2" "262.9" "287.2" "347.5" "233.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "High" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.000" "False" "11.246" "2" "4" "5" "4" "1960" "211.6" "9.04" "15.73" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "" "Matrix metalloproteinases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8560465734379748063" "False" "High" "IsMasterProtein" "Q9NP77" "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1" "0.000" "False" "11.233" "12" "2" "2" "2" "194" "22.6" "5.33" "8.21" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04722" "29101" "ENSG00000160075" "SSU72" "hsa:29101; Q9BZS6; Q9H933; Q9NP77" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.150" "0.896" "1.062" "1.060" "1.057" "1.027" "0.741" "1.073" "5.421" "150.6" "173.2" "134.9" "160.0" "159.7" "159.2" "154.6" "111.6" "161.6" "816.4" "" "" "" "" "" "" "" "" "" "" "133.6" "143.5" "117.7" "119.6" "133.2" "146.3" "130.7" "92.2" "148.2" "816.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6043463436452304537" "False" "High" "IsMasterProtein" "Q5SSJ5" "Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1" "0.000" "False" "11.205" "5" "3" "6" "3" "553" "61.2" "9.67" "15.19" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "50809" "ENSG00000127483" "HP1BP3" "A6NI71; A8K5D7; B3KMZ8; B4E210; hsa:50809; Q05BI0; Q5SSJ5; Q5SSJ6; Q5SWC6; Q6PIM9; Q8NDF0; Q9UHY0" "" "" "0" "0" "0.951" "0.911" "0.898" "0.832" "0.749" "0.795" "0.764" "0.872" "0.829" "711.7" "676.5" "648.0" "639.2" "592.2" "532.7" "565.5" "543.6" "620.6" "590.1" "" "" "" "" "" "" "" "" "" "" "631.1" "560.4" "565.4" "478.0" "493.8" "489.4" "477.9" "449.3" "569.2" "590.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926875629278284651" "False" "High" "IsMasterProtein" "Q9UKV5" "E3 ubiquitin-protein ligase AMFR OS=Homo sapiens OX=9606 GN=AMFR PE=1 SV=2" "0.000" "False" "11.195" "4" "1" "1" "1" "643" "72.9" "6.39" "6.47" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf02845, Pf13639, Pf18442" "267" "ENSG00000159461" "AMFR" "hsa:267; P26442; Q8IZ70; Q9UKV5" "ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Sterol regulatory element-binding proteins (SREBP) signaling" "3" "0" "0.974" "0.857" "0.832" "0.809" "0.631" "1.053" "0.734" "0.801" "0.620" "34.5" "33.6" "29.6" "28.7" "27.9" "21.8" "36.4" "25.3" "27.6" "21.4" "" "" "" "" "" "" "" "" "" "" "30.6" "27.8" "25.8" "21.5" "23.3" "20.0" "30.7" "20.9" "25.3" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7450881141775825578" "False" "High" "IsMasterProtein" "Q9H8W3" "Protein FAM204A OS=Homo sapiens OX=9606 GN=FAM204A PE=1 SV=1" "0.000" "False" "11.173" "5" "1" "2" "1" "233" "27.0" "7.91" "7.31" "1" "" "" "" "" "63877" "ENSG00000165669" "FAM204A" "D3DRC6; hsa:63877; Q5T373; Q9H5V5; Q9H8W3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7689745804882425318" "False" "High" "IsMasterProtein" "Q6XQN6" "Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2" "0.000" "False" "11.143" "5" "3" "3" "3" "538" "57.5" "5.68" "10.90" "3" "other metabolic processes;stress response" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf17767, Pf17956" "93100" "ENSG00000147813; ENSG00000278488" "NAPRT" "A7BFI3; hsa:93100; Q6PJL1; Q6XQN4; Q6XQN5; Q6XQN6; Q8N5E8; Q9BRG0" "Neutrophil degranulation; Nicotinamide salvaging" "NAD+ biosynthetic pathways" "3" "0" "1.073" "0.922" "1.065" "1.036" "1.039" "1.033" "0.945" "0.939" "0.556" "626.5" "672.3" "577.8" "667.2" "648.8" "650.9" "646.9" "592.1" "588.5" "348.3" "" "" "" "" "" "" "" "" "" "" "555.5" "556.9" "504.2" "499.0" "541.0" "597.9" "546.7" "489.4" "539.8" "348.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5797732752713602243" "False" "High" "IsMasterProtein" "Q15050" "Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2" "0.000" "False" "11.130" "7" "3" "3" "3" "365" "41.2" "10.70" "9.69" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf04939" "23212" "ENSG00000179041" "RRS1" "hsa:23212; Q15050; Q9BUX8" "" "" "0" "0" "1.032" "0.775" "0.819" "0.704" "0.530" "0.545" "0.744" "0.772" "0.325" "569.8" "587.9" "441.4" "466.4" "401.0" "302.0" "310.5" "424.2" "440.0" "185.2" "" "" "" "" "" "" "" "" "" "" "505.3" "487.0" "385.1" "348.8" "334.4" "277.5" "262.4" "350.6" "403.5" "185.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874402221689570626" "False" "High" "IsMasterProtein" "Q86W56" "Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1" "0.000" "False" "11.114" "3" "2" "2" "2" "976" "111.0" "6.43" "7.65" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05028, Pf20811" "670; 8505" "ENSG00000227345" "PARG" "A5YBK3; B2RC24; B4DIU5; B4DYR4; hsa:8505; I6RUV3; Q6E4P6; Q6E4P7; Q7Z742; Q86W56; Q9Y4W7" "POLB-Dependent Long Patch Base Excision Repair" "10q11.21q11.23 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042758646776431623" "False" "High" "IsMasterProtein" "Q9UQR0" "Sex comb on midleg-like protein 2 OS=Homo sapiens OX=9606 GN=SCML2 PE=1 SV=1" "0.000" "False" "11.085" "5" "3" "4" "3" "700" "77.2" "8.54" "10.08" "3" "other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820, Pf12140, Pf17208" "10389" "ENSG00000102098" "SCML2" "hsa:10389; Q5JXE6; Q86U98; Q8IWD0; Q8NDP2; Q9UGC5; Q9UQR0" "" "" "0" "0" "0.788" "0.819" "0.675" "0.945" "0.965" "0.825" "0.051" "0.909" "13.401" "52.5" "41.3" "43.0" "35.4" "49.6" "50.6" "43.3" "2.7" "47.7" "703.0" "" "" "" "" "" "" "" "" "" "" "46.5" "34.2" "37.5" "26.5" "41.3" "46.5" "36.6" "2.2" "43.7" "703.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436639350970849740" "False" "High" "IsMasterProtein" "Q9UHB4" "NADPH-dependent diflavin oxidoreductase 1 OS=Homo sapiens OX=9606 GN=NDOR1 PE=1 SV=1" "0.000" "False" "11.074" "5" "2" "3" "2" "597" "66.7" "6.35" "9.70" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "27158" "ENSG00000188566" "NDOR1" "D3YTG6; D3YTH9; hsa:27158; Q5VSG4; Q86US9; Q96BC6; Q9UHB4" "Cytosolic iron-sulfur cluster assembly" "" "1" "0" "1.159" "0.827" "1.274" "1.006" "0.761" "1.107" "0.948" "0.929" "0.836" "264.7" "306.9" "218.8" "337.2" "266.4" "201.3" "293.0" "251.0" "245.9" "221.2" "" "" "" "" "" "" "" "" "" "" "234.7" "254.2" "190.9" "252.2" "222.2" "184.9" "247.6" "207.4" "225.5" "221.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2428159041387120762" "False" "High" "IsMasterProtein" "Q9Y664" "KICSTOR complex protein kaptin OS=Homo sapiens OX=9606 GN=KPTN PE=1 SV=2" "0.000" "False" "11.074" "8" "3" "3" "3" "436" "48.1" "5.26" "9.11" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "" "11133" "ENSG00000118162" "KPTN" "B3KN86; B4DQ76; hsa:11133; Q96GT1; Q9Y664" "Amino acids regulate mTORC1" "" "1" "0" "0.885" "0.843" "1.163" "0.792" "0.978" "1.046" "0.741" "0.826" "0.755" "47.6" "42.1" "40.1" "55.3" "37.7" "46.5" "49.7" "35.2" "39.3" "35.9" "" "" "" "" "" "" "" "" "" "" "42.2" "34.8" "35.0" "41.4" "31.4" "42.7" "42.0" "29.1" "36.0" "35.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945002004547854697" "False" "High" "IsMasterProtein" "Q8N7B6" "PACRG-like protein OS=Homo sapiens OX=9606 GN=PACRGL PE=1 SV=2" "0.000" "False" "11.046" "13" "3" "3" "3" "248" "27.1" "9.67" "9.99" "3" "" "" "" "Pf10274" "133015" "ENSG00000163138" "PACRGL" "B2RDB9; B4DFF8; B4DMN7; hsa:133015; Q8N7B6; Q8TBA8" "" "" "0" "0" "1.058" "1.052" "0.972" "0.933" "1.009" "0.910" "1.051" "0.978" "0.996" "261.9" "277.2" "275.6" "254.6" "244.4" "264.3" "238.4" "275.3" "256.2" "260.9" "" "" "" "" "" "" "" "" "" "" "232.3" "229.6" "240.5" "190.4" "203.8" "242.7" "201.5" "227.5" "234.9" "260.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8996103182095070186" "False" "High" "IsMasterProtein" "Q9UBF6" "RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1" "0.000" "False" "11.042" "11" "1" "2" "1" "113" "12.7" "5.44" "8.18" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9616" "ENSG00000114125" "RNF7" "A8K1H9; A8MTB5; C9JYL3; D3DNF7; D3DNF8; hsa:9616; Q9BXN8; Q9UBF6; Q9Y5M7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Inactivation of CSF3 (G-CSF) signaling" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Modulators of TCR signaling and T cell activation" "5" "0" "0.794" "0.851" "1.017" "0.813" "0.858" "1.047" "1.101" "0.831" "0.386" "72.6" "57.6" "61.7" "73.8" "59.0" "62.2" "76.0" "79.9" "60.3" "28.0" "" "" "" "" "" "" "" "" "" "" "64.4" "47.7" "53.9" "55.2" "49.2" "57.2" "64.2" "66.0" "55.3" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.000" "False" "11.031" "6" "3" "3" "1" "520" "59.6" "8.21" "9.77" "3" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "3" "0" "0.847" "0.799" "0.898" "0.740" "0.731" "0.755" "0.715" "0.739" "0.644" "189.3" "160.3" "151.2" "169.9" "140.1" "138.4" "142.9" "135.4" "140.0" "121.9" "" "" "" "" "" "" "" "" "" "" "167.9" "132.8" "131.9" "127.1" "116.8" "127.2" "120.8" "111.9" "128.4" "121.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691661012823891973" "False" "High" "IsMasterProtein" "P54278" "Mismatch repair endonuclease PMS2 OS=Homo sapiens OX=9606 GN=PMS2 PE=1 SV=2" "0.000" "False" "11.030" "3" "2" "2" "2" "862" "95.7" "6.86" "7.12" "2" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01119, Pf08676, Pf13589" "5395" "ENSG00000122512" "PMS2" "B2R610; hsa:5395; P54278; Q52LH6; Q5FBW9; Q5FBX1; Q5FBX2; Q75MR2" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "Male infertility; DNA repair pathways, full network; DNA mismatch repair" "8" "0" "0.691" "0.665" "0.742" "0.732" "0.684" "0.697" "0.587" "0.619" "2.774" "78.1" "54.0" "52.0" "58.0" "57.2" "53.4" "54.5" "45.9" "48.3" "216.6" "" "" "" "" "" "" "" "" "" "" "69.3" "44.7" "45.3" "43.3" "47.7" "49.1" "46.0" "37.9" "44.3" "216.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5430220103658382973" "False" "High" "IsMasterProtein" "Q969Q0" "Ribosomal protein eL42-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "0.000" "False" "11.018" "24" "3" "5" "3" "106" "12.5" "10.65" "14.95" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "0.993" "0.972" "1.123" "1.063" "1.115" "1.180" "1.132" "0.924" "0.664" "430.8" "427.7" "418.6" "483.7" "458.1" "480.3" "508.4" "487.8" "398.0" "286.1" "" "" "" "" "" "" "" "" "" "" "382.0" "354.3" "365.3" "361.7" "382.0" "441.2" "429.7" "403.2" "365.0" "286.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4300221756741418571" "False" "High" "IsMasterProtein" "P59768" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 OS=Homo sapiens OX=9606 GN=GNG2 PE=1 SV=2" "0.000" "False" "11.011" "32" "2" "2" "2" "71" "7.8" "7.99" "7.99" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "54331" "ENSG00000186469" "GNG2" "hsa:54331; P59768; Q5JPE2; Q6P9A9" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "36" "0" "1.115" "0.901" "1.145" "1.044" "0.990" "1.187" "1.047" "1.495" "0.694" "135.2" "150.7" "121.8" "154.9" "141.2" "133.9" "160.5" "141.6" "202.2" "93.9" "" "" "" "" "" "" "" "" "" "" "119.9" "124.9" "106.3" "115.8" "117.8" "123.0" "135.7" "117.0" "185.4" "93.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711060710327679778" "False" "High" "IsMasterProtein" "O75886" "Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1" "0.000" "False" "10.986" "7" "4" "4" "2" "525" "58.1" "5.07" "11.61" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "10254" "ENSG00000115145" "STAM2" "A8K8A0; D3DPA1; hsa:10254; O75886; Q7LDQ0; Q9UF58" "Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "EGF/EGFR signaling pathway" "9" "0" "0.818" "1.307" "0.710" "0.951" "1.212" "1.134" "0.780" "1.038" "4.119" "22.5" "18.4" "29.4" "16.0" "21.4" "27.3" "25.5" "17.6" "23.4" "92.8" "" "" "" "" "" "" "" "" "" "" "20.0" "15.3" "25.7" "12.0" "17.9" "25.1" "21.6" "14.5" "21.5" "92.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531363712700192847" "False" "High" "IsMasterProtein" "Q9NZJ6" "Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ3 PE=1 SV=3" "0.000" "False" "10.976" "10" "4" "5" "4" "369" "41.0" "7.42" "14.25" "4" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08241" "51805" "ENSG00000132423" "COQ3" "B3KPX0; hsa:51805; Q5T061; Q6P4F0; Q8IXG6; Q96BG1; Q9H0N1; Q9NZJ6" "Ubiquinol biosynthesis" "" "1" "0" "0.966" "0.997" "0.831" "0.903" "1.052" "0.891" "0.982" "0.903" "0.768" "322.4" "311.4" "321.3" "267.9" "291.1" "339.1" "287.2" "316.7" "291.3" "247.8" "" "" "" "" "" "" "" "" "" "" "285.9" "258.0" "280.4" "200.3" "242.7" "311.5" "242.7" "261.8" "267.1" "247.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613056624096108144" "False" "High" "IsMasterProtein" "Q7Z7E8" "Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1" "0.000" "False" "10.973" "10" "5" "6" "4" "422" "46.1" "5.10" "12.62" "5" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "55585" "ENSG00000160714" "UBE2Q1" "B4DF92; hsa:55585; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q7Z7E8; Q96MV4; Q9BVX5; Q9UGL6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.028" "0.897" "0.860" "0.814" "0.882" "0.871" "0.648" "0.788" "3.441" "454.7" "467.3" "408.0" "391.1" "370.0" "400.9" "395.9" "294.7" "358.3" "1564.8" "" "" "" "" "" "" "" "" "" "" "403.3" "387.1" "356.0" "292.5" "308.6" "368.3" "334.6" "243.6" "328.6" "1564.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3766879511259281877" "False" "High" "IsMasterProtein" "Q96CM8" "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2" "0.000" "False" "10.972" "3" "2" "2" "2" "615" "68.1" "7.55" "8.99" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "80221" "ENSG00000167107" "ACSF2" "B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2" "Mitochondrial Fatty Acid Beta-Oxidation" "Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "3" "0" "0.954" "0.988" "0.990" "1.061" "1.204" "1.501" "1.321" "1.302" "2.636" "351.8" "335.8" "347.7" "348.2" "373.2" "423.6" "528.2" "464.9" "458.3" "927.5" "" "" "" "" "" "" "" "" "" "" "312.0" "278.2" "303.4" "260.4" "311.2" "389.1" "446.4" "384.3" "420.3" "927.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5896962611559729209" "False" "High" "IsMasterProtein" "O14734" "Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1" "0.000" "False" "10.954" "10" "3" "3" "3" "319" "35.9" "7.56" "11.22" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf02551, Pf13622" "10005" "ENSG00000101473" "ACOT8" "hsa:10005; O14734; O15261; Q17RX4" "Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "" "5" "0" "1.067" "0.976" "1.053" "1.049" "1.107" "1.035" "1.003" "0.960" "0.648" "452.2" "482.7" "441.1" "476.0" "474.3" "500.7" "468.0" "453.3" "433.9" "293.0" "" "" "" "" "" "" "" "" "" "" "401.0" "399.8" "384.9" "356.0" "395.5" "459.9" "395.6" "374.7" "398.0" "293.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307907366133705571" "False" "High" "IsMasterProtein" "Q9UJY4" "ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3" "0.000" "False" "10.938" "4" "3" "3" "2" "613" "67.1" "6.55" "11.03" "3" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23062" "ENSG00000103365" "GGA2" "D3DWF0; hsa:23062; O14564; Q9NYN2; Q9UJY4; Q9UPS2" "Amyloid fiber formation; TBC/RABGAPs" "" "2" "0" "0.910" "0.849" "1.026" "0.949" "0.954" "0.901" "0.580" "0.976" "8.806" "111.9" "101.8" "95.0" "114.8" "106.1" "106.8" "100.8" "64.9" "109.2" "985.1" "" "" "" "" "" "" "" "" "" "" "99.2" "84.4" "82.9" "85.8" "88.5" "98.1" "85.2" "53.7" "100.1" "985.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388377478201374307" "False" "High" "IsMasterProtein" "A0A024R1R8" "Translation machinery-associated protein 7B OS=Homo sapiens OX=9606 GN=TMA7B PE=3 SV=1" "0.000" "False" "10.933" "23" "2" "6" "1" "64" "7.1" "9.99" "19.96" "2" "" "" "" "Pf09072" "" "ENSG00000225528" "TMA7B" "A0A024R1R8" "" "" "0" "1" "0.915" "0.923" "0.942" "0.875" "0.918" "0.956" "0.968" "0.912" "0.372" "1340.6" "1226.0" "1237.3" "1262.4" "1172.4" "1230.2" "1281.2" "1297.9" "1223.1" "499.2" "" "" "" "" "" "" "" "" "" "" "1188.8" "1015.6" "1079.6" "944.1" "977.6" "1130.1" "1082.8" "1072.8" "1121.7" "499.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4461868117343589472" "False" "High" "IsMasterProtein" "Q66K14" "TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3" "0.000" "False" "10.926" "2" "1" "1" "1" "1250" "140.4" "5.25" "6.19" "1" "" "other membranes" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23061" "ENSG00000197226; ENSG00000284400" "TBC1D9B" "D3DWQ5; D3DWQ6; hsa:23061; O75163; Q53EY0; Q66K14; Q6MZI2; Q96H49" "" "" "0" "0" "0.836" "0.582" "0.686" "0.793" "0.631" "0.713" "0.519" "0.729" "3.237" "21.2" "17.7" "12.4" "14.6" "16.8" "13.4" "15.1" "11.0" "15.5" "68.7" "" "" "" "" "" "" "" "" "" "" "18.8" "14.7" "10.8" "10.9" "14.0" "12.3" "12.8" "9.1" "14.2" "68.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756136000491077603" "False" "High" "IsMasterProtein" "P08236" "Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2" "0.000" "False" "10.914" "6" "4" "5" "4" "651" "74.7" "7.02" "15.33" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00703, Pf02836, Pf02837" "2990" "ENSG00000169919" "GUSB" "B4E1F6; E9PCV0; hsa:2990; P08236; Q549U0; Q96CL9" "Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation; MPS VII - Sly syndrome" "Glycosaminoglycan degradation" "5" "0" "1.080" "0.949" "1.064" "1.018" "1.200" "1.023" "0.929" "0.949" "0.716" "198.3" "214.2" "188.1" "210.9" "201.9" "237.9" "202.8" "184.1" "188.2" "142.0" "" "" "" "" "" "" "" "" "" "" "175.8" "177.4" "164.1" "157.8" "168.4" "218.5" "171.4" "152.2" "172.6" "142.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982542769367786087" "False" "High" "IsMasterProtein" "O75116" "Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4" "0.000" "False" "10.905" "2" "2" "2" "1" "1388" "160.8" "6.02" "7.26" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "9475" "ENSG00000134318" "ROCK2" "hsa:9475; O75116; Q53QZ0; Q53SJ7; Q9UQN5" "Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1532626323839813541" "False" "High" "IsMasterProtein" "Q99622" "Protein C10 OS=Homo sapiens OX=9606 GN=C12orf57 PE=1 SV=1" "0.000" "False" "10.901" "19" "2" "2" "2" "126" "13.2" "5.14" "8.68" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf14974" "113246" "ENSG00000111678" "C12orf57" "B2R4Q6; hsa:113246; Q99622" "" "" "0" "0" "0.886" "0.936" "1.045" "0.919" "0.976" "0.880" "0.753" "0.889" "3.190" "439.0" "389.0" "410.8" "458.6" "403.6" "428.5" "386.2" "330.7" "390.3" "1400.3" "" "" "" "" "" "" "" "" "" "" "389.3" "322.3" "358.4" "342.9" "336.5" "393.7" "326.4" "273.3" "358.0" "1400.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "10.896" "2" "4" "4" "4" "1593" "182.7" "8.44" "12.14" "4" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.027" "1.011" "0.961" "0.965" "1.070" "0.960" "0.909" "1.057" "2.089" "343.8" "353.1" "347.4" "330.4" "331.7" "367.8" "330.0" "312.5" "363.4" "718.0" "" "" "" "" "" "" "" "" "" "" "304.9" "292.5" "303.1" "247.1" "276.6" "337.9" "278.9" "258.3" "333.3" "718.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2766829585988969351" "False" "High" "IsMasterProtein" "O75190" "DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2" "0.000" "False" "10.889" "10" "3" "4" "3" "326" "36.1" "9.16" "13.92" "3" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00226" "10049" "ENSG00000105993" "DNAJB6" "A4D232; A8K7D8; A8KAG0; B4DN73; E9PCZ2; hsa:10049; O75190; O95806; Q53EN8; Q59EF2; Q6FIC8; Q75MA2; Q9UIK6" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.872" "1.141" "1.002" "0.879" "0.945" "0.957" "0.930" "1.071" "1.499" "56.6" "49.3" "64.5" "56.7" "49.7" "53.4" "54.1" "52.6" "60.6" "84.8" "" "" "" "" "" "" "" "" "" "" "50.2" "40.9" "56.3" "42.4" "41.4" "49.1" "45.7" "43.5" "55.5" "84.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747450166338589829" "False" "High" "IsMasterProtein" "Q8IUE6" "Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=H2AC21 PE=1 SV=3" "0.000" "False" "10.886" "18" "3" "8" "1" "130" "14.0" "10.89" "22.73" "3" "" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "317772" "ENSG00000184270" "H2AC21" "hsa:317772; Q8IUE6" "HCMV Late Events; UCH proteinases; Ub-specific processing proteases; HCMV Early Events; HDACs deacetylate histones; Metalloprotease DUBs; RMTs methylate histone arginines; HATs acetylate histones" "" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4954031466942572679" "False" "High" "IsMasterProtein" "Q6NW29" "RWD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RWDD4 PE=1 SV=3" "0.000" "False" "10.865" "10" "2" "2" "2" "188" "21.2" "5.31" "8.58" "2" "" "" "" "Pf05773" "201965" "ENSG00000182552" "RWDD4" "B2RDE9; B4DDP2; hsa:201965; Q6NW29; Q75LA9; Q8WVW2" "" "" "0" "0" "0.995" "1.079" "0.960" "1.084" "1.028" "1.036" "0.783" "1.142" "3.862" "213.8" "212.6" "230.7" "205.2" "231.7" "219.7" "221.4" "167.3" "244.2" "825.7" "" "" "" "" "" "" "" "" "" "" "189.6" "176.1" "201.3" "153.4" "193.2" "201.8" "187.1" "138.3" "224.0" "825.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6923013739007896551" "False" "High" "IsMasterProtein" "P60033" "CD81 antigen OS=Homo sapiens OX=9606 GN=CD81 PE=1 SV=1" "0.000" "False" "10.860" "13" "3" "3" "3" "236" "25.8" "5.29" "8.06" "3" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00335" "975" "ENSG00000110651" "CD81" "hsa:975; P18582; P60033; Q5U0J6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade" "B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome" "6" "0" "1.272" "1.180" "1.190" "1.217" "1.248" "1.264" "1.067" "1.619" "0.922" "124.6" "158.5" "147.1" "148.3" "151.7" "155.6" "157.5" "132.9" "201.8" "114.9" "" "" "" "" "" "" "" "" "" "" "110.5" "131.3" "128.4" "110.9" "126.5" "142.9" "133.1" "109.9" "185.0" "114.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "High" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.000" "False" "10.827" "7" "5" "6" "5" "709" "79.7" "6.34" "16.53" "5" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "0.963" "0.856" "1.077" "0.885" "0.993" "1.086" "0.736" "0.958" "3.818" "342.5" "329.8" "293.3" "369.0" "303.3" "340.0" "372.0" "252.0" "328.0" "1307.6" "" "" "" "" "" "" "" "" "" "" "303.8" "273.2" "255.9" "275.9" "252.9" "312.4" "314.4" "208.3" "300.8" "1307.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2978485946285835937" "False" "High" "IsMasterProtein" "Q8NHH9" "Atlastin-2 OS=Homo sapiens OX=9606 GN=ATL2 PE=1 SV=2" "0.000" "False" "10.822" "6" "3" "3" "3" "583" "66.2" "5.48" "10.35" "3" "cell organization and biogenesis" "other membranes;ER/Golgi" "other molecular function" "Pf02263, Pf02841" "64225" "ENSG00000119787" "ATL2" "B7Z1X2; B7Z7X8; hsa:64225; Q4ZG30; Q7Z630; Q8NHH8; Q8NHH9; Q9H5M7" "" "" "0" "0" "1.158" "0.953" "1.081" "0.993" "0.815" "0.836" "0.858" "0.966" "1.199" "81.8" "94.8" "78.0" "88.5" "81.3" "66.7" "68.4" "70.2" "79.0" "98.1" "" "" "" "" "" "" "" "" "" "" "72.6" "78.5" "68.1" "66.2" "67.8" "61.3" "57.8" "58.0" "72.5" "98.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5677827102624180499" "False" "High" "IsMasterProtein" "Q96IQ9" "Zinc finger protein 414 OS=Homo sapiens OX=9606 GN=ZNF414 PE=1 SV=2" "0.000" "False" "10.786" "11" "3" "4" "3" "312" "32.8" "7.81" "11.63" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15909" "84330" "ENSG00000133250" "ZNF414" "A8MY94; hsa:84330; Q96IQ9" "" "" "0" "0" "1.092" "0.992" "0.980" "0.920" "0.988" "0.908" "0.975" "1.016" "1.501" "390.5" "426.3" "387.4" "382.8" "359.1" "385.8" "354.7" "380.5" "396.6" "586.1" "" "" "" "" "" "" "" "" "" "" "346.3" "353.1" "338.0" "286.3" "299.4" "354.4" "299.8" "314.5" "363.7" "586.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3284671458686948130" "False" "High" "IsMasterProtein" "Q14498" "RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2" "0.000" "False" "10.773" "6" "4" "4" "4" "530" "59.3" "10.10" "9.34" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00076, Pf15519" "9584" "ENSG00000131051" "RBM39" "A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499" "mRNA Splicing - Major Pathway" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "1.032" "1.025" "1.053" "1.031" "1.038" "0.973" "0.770" "1.049" "5.474" "333.2" "343.7" "341.4" "350.8" "343.6" "345.8" "324.3" "256.6" "349.6" "1824.1" "" "" "" "" "" "" "" "" "" "" "295.5" "284.7" "297.9" "262.3" "286.5" "317.6" "274.1" "212.1" "320.7" "1824.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "10.767" "15" "3" "3" "3" "237" "26.4" "10.86" "10.29" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.000" "0.948" "1.035" "1.102" "0.972" "1.029" "1.097" "1.060" "0.543" "259.6" "259.6" "246.1" "268.7" "286.1" "252.4" "267.2" "284.6" "275.2" "140.9" "" "" "" "" "" "" "" "" "" "" "230.2" "215.1" "214.8" "201.0" "238.6" "231.8" "225.8" "235.3" "252.4" "140.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.000" "False" "10.766" "7" "3" "3" "3" "398" "45.5" "8.88" "10.18" "3" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.927" "0.733" "0.829" "0.745" "0.604" "0.824" "0.674" "0.870" "3.505" "423.3" "392.4" "310.1" "350.8" "315.4" "255.9" "348.9" "285.3" "368.3" "1484.0" "" "" "" "" "" "" "" "" "" "" "375.4" "325.1" "270.6" "262.4" "263.0" "235.0" "294.9" "235.8" "337.8" "1484.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058994257240808720" "False" "High" "IsMasterProtein" "Q9ULR5" "Polyadenylate-binding protein-interacting protein 2B OS=Homo sapiens OX=9606 GN=PAIP2B PE=1 SV=2" "0.000" "False" "10.765" "15" "2" "3" "2" "123" "14.2" "4.17" "9.74" "2" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "400961" "ENSG00000124374" "PAIP2B" "hsa:400961; Q9ULR5" "" "" "0" "0" "0.892" "0.891" "0.896" "0.968" "0.939" "0.849" "0.923" "0.963" "0.694" "325.1" "290.0" "289.5" "291.4" "314.6" "305.1" "276.1" "299.9" "312.9" "225.6" "" "" "" "" "" "" "" "" "" "" "288.3" "240.2" "252.6" "217.9" "262.4" "280.3" "233.4" "247.9" "287.0" "225.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108294970833743211" "False" "High" "IsMasterProtein" "Q5XUX1" "F-box/WD repeat-containing protein 9 OS=Homo sapiens OX=9606 GN=FBXW9 PE=1 SV=3" "0.000" "False" "10.750" "6" "2" "2" "2" "458" "50.7" "6.48" "8.25" "2" "" "cytosol" "" "Pf00400, Pf12937" "84261" "ENSG00000132004" "FBXW9" "B3KVP7; hsa:84261; Q5XUX1; Q9BT89" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "1.110" "1.180" "1.116" "1.155" "1.249" "1.071" "1.151" "0.974" "0.648" "128.6" "142.7" "151.8" "143.5" "148.6" "160.6" "137.7" "148.0" "125.2" "83.4" "" "" "" "" "" "" "" "" "" "" "114.0" "118.2" "132.4" "107.4" "123.9" "147.6" "116.3" "122.3" "114.9" "83.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6908456215771720414" "False" "High" "IsMasterProtein" "Q96LC7" "Sialic acid-binding Ig-like lectin 10 OS=Homo sapiens OX=9606 GN=SIGLEC10 PE=1 SV=3" "0.000" "False" "10.719" "4" "2" "2" "2" "697" "76.5" "8.35" "7.11" "2" "cell adhesion;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf07679, Pf07686, Pf13927" "89790" "ENSG00000142512" "SIGLEC10" "A8K1I5; A8K3C7; C9JJ33; C9JM10; F8W917; hsa:89790; Q3MIR5; Q6UXI8; Q96G54; Q96LC7; Q96LC8" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710648290314938534" "False" "High" "IsMasterProtein" "P01906" "HLA class II histocompatibility antigen, DQ alpha 2 chain OS=Homo sapiens OX=9606 GN=HLA-DQA2 PE=1 SV=2" "0.000" "False" "10.711" "7" "2" "2" "1" "255" "28.0" "4.88" "8.05" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00993, Pf07654" "3118" "ENSG00000206301; ENSG00000223793; ENSG00000225103; ENSG00000231526; ENSG00000231823; ENSG00000233192; ENSG00000237541; ENSG00000257473" "HLA-DQA2" "A2BF37; B0V0E7; hsa:3118; O19789; P01906; Q5SQ94; Q5SR04" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482584710342815386" "False" "High" "IsMasterProtein" "Q15773" "Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1" "0.000" "False" "10.704" "11" "2" "3" "2" "248" "28.1" "6.90" "10.22" "2" "other biological processes" "nucleus;other cell component" "" "Pf10248" "8079" "ENSG00000089693" "MLF2" "hsa:8079; Q15773" "" "" "0" "0" "1.126" "1.218" "1.243" "1.238" "1.173" "1.142" "0.790" "1.059" "7.040" "114.4" "128.8" "139.4" "142.2" "141.7" "134.2" "130.7" "90.4" "121.2" "805.7" "" "" "" "" "" "" "" "" "" "" "101.5" "106.7" "121.6" "106.3" "118.2" "123.3" "110.5" "74.7" "111.2" "805.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1632540778200031519" "False" "High" "IsMasterProtein" "Q9BVA0" "Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1" "0.000" "False" "10.696" "4" "2" "2" "2" "655" "72.3" "7.56" "8.30" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf13925" "10300" "ENSG00000140854" "KATNB1" "A6NCG6; hsa:10300; O60620; Q9BVA0" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "1.027" "0.862" "1.002" "0.994" "0.882" "1.148" "1.097" "1.001" "1.572" "172.6" "177.2" "148.9" "172.9" "171.7" "152.2" "198.1" "189.3" "172.9" "271.3" "" "" "" "" "" "" "" "" "" "" "153.1" "146.8" "129.9" "129.3" "143.2" "139.8" "167.4" "156.5" "158.6" "271.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.000" "False" "10.672" "19" "3" "4" "2" "130" "14.4" "9.11" "14.62" "3" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "0" "0.957" "0.956" "1.007" "0.933" "0.995" "1.006" "1.021" "0.932" "0.419" "661.0" "632.7" "631.6" "665.9" "616.9" "657.4" "664.8" "674.9" "615.7" "277.1" "" "" "" "" "" "" "" "" "" "" "586.1" "524.1" "551.1" "498.0" "514.4" "603.9" "561.9" "557.9" "564.7" "277.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1616730099319626279" "False" "High" "IsMasterProtein" "O43298" "Zinc finger and BTB domain-containing protein 43 OS=Homo sapiens OX=9606 GN=ZBTB43 PE=1 SV=1" "0.000" "False" "10.640" "5" "2" "3" "2" "467" "52.6" "5.76" "9.61" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "23099" "ENSG00000169155" "ZBTB43" "hsa:23099; O43298; Q5JU96" "" "" "0" "0" "0.969" "1.054" "1.126" "1.174" "0.994" "1.099" "1.038" "1.059" "0.780" "158.5" "153.6" "167.0" "178.5" "186.1" "157.5" "174.2" "164.5" "167.9" "123.6" "" "" "" "" "" "" "" "" "" "" "140.6" "127.3" "145.7" "133.5" "155.2" "144.7" "147.2" "135.9" "153.9" "123.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699160270543076643" "False" "High" "IsMasterProtein" "Q14789" "Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2" "0.000" "False" "10.635" "1" "5" "7" "4" "3259" "375.8" "5.00" "17.29" "5" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "nucleic acid binding activity" "" "2804" "ENSG00000173230" "GOLGB1" "B2ZZ91; D3DN92; E7EP74; F1T0J2; hsa:2804; Q14398; Q14789" "Golgi Associated Vesicle Biogenesis; COPI-mediated anterograde transport; Signaling by FLT3 fusion proteins" "" "3" "0" "1.027" "1.020" "1.045" "1.032" "1.002" "1.052" "0.932" "1.020" "1.333" "359.6" "369.2" "366.8" "375.8" "371.3" "360.5" "378.4" "335.0" "366.9" "479.4" "" "" "" "" "" "" "" "" "" "" "318.9" "305.9" "320.1" "281.1" "309.6" "331.1" "319.8" "276.9" "336.5" "479.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6163151869954126091" "False" "High" "IsMasterProtein" "Q9P2S5" "WD repeat-containing protein WRAP73 OS=Homo sapiens OX=9606 GN=WRAP73 PE=1 SV=1" "0.000" "False" "10.625" "10" "4" "4" "4" "460" "51.6" "6.81" "9.60" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "49856" "ENSG00000116213" "WRAP73" "hsa:49856; Q5T0D6; Q9BUH7; Q9NTK7; Q9NX56; Q9P2S5" "" "" "0" "0" "1.294" "1.004" "1.212" "1.129" "1.129" "1.137" "1.246" "0.886" "0.540" "141.0" "182.5" "141.6" "171.0" "159.2" "159.2" "160.4" "175.8" "125.0" "76.1" "" "" "" "" "" "" "" "" "" "" "125.1" "151.2" "123.5" "127.9" "132.7" "146.3" "135.6" "145.3" "114.6" "76.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5096502141000675032" "False" "High" "IsMasterProtein" "Q8TBB5" "Kelch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KLHDC4 PE=1 SV=1" "0.000" "False" "10.618" "7" "3" "4" "3" "520" "57.9" "5.72" "13.74" "3" "" "" "" "Pf13415, Pf13418" "54758" "ENSG00000104731" "KLHDC4" "D3DUN3; D3DUN4; D3DUN5; hsa:54758; Q8TBB5; Q96F29; Q9BVN3" "" "" "0" "0" "1.000" "1.024" "0.958" "1.000" "1.127" "0.961" "1.026" "1.062" "1.321" "226.0" "226.0" "231.4" "216.4" "225.9" "254.7" "217.1" "231.8" "240.1" "298.6" "" "" "" "" "" "" "" "" "" "" "200.4" "187.2" "201.9" "161.9" "188.4" "234.0" "183.5" "191.6" "220.2" "298.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1278451535878426302" "False" "High" "IsMasterProtein" "Q07820" "Induced myeloid leukemia cell differentiation protein Mcl-1 OS=Homo sapiens OX=9606 GN=MCL1 PE=1 SV=3" "0.000" "False" "10.612" "10" "2" "2" "2" "350" "37.3" "5.66" "10.55" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "4170" "ENSG00000143384" "MCL1" "B2R6B2; D3DV03; D3DV04; hsa:4170; Q07820; Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1" "Interleukin-4 and Interleukin-13 signaling; Signaling by ALK fusions and activated point mutants" "Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Pleural mesothelioma" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.000" "False" "10.604" "14" "2" "2" "2" "217" "23.3" "4.98" "10.36" "2" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "1.034" "1.024" "1.016" "1.098" "1.053" "1.092" "1.068" "1.087" "0.643" "265.4" "274.5" "271.9" "269.7" "291.4" "279.5" "289.8" "283.4" "288.6" "170.7" "" "" "" "" "" "" "" "" "" "" "235.4" "227.4" "237.2" "201.7" "243.0" "256.7" "244.9" "234.3" "264.7" "170.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1870630596764229112" "False" "High" "IsMasterProtein" "Q15643" "Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3" "0.000" "False" "10.594" "2" "3" "3" "3" "1979" "227.4" "5.26" "6.78" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytoskeleton;ER/Golgi" "other molecular function" "" "9321" "ENSG00000100815" "TRIP11" "B2RUT2; hsa:9321; O14689; O15154; O95949; Q15643; Q6MZL5" "Intraflagellar transport; Intra-Golgi traffic; Signaling by FLT3 fusion proteins" "" "3" "0" "0.977" "0.899" "0.942" "0.904" "0.928" "0.904" "1.003" "0.945" "1.037" "267.0" "260.9" "240.0" "251.6" "241.3" "247.7" "241.3" "267.8" "252.2" "276.9" "" "" "" "" "" "" "" "" "" "" "236.7" "216.1" "209.4" "188.1" "201.2" "227.5" "204.0" "221.3" "231.3" "276.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635487615117841616" "False" "High" "IsMasterProtein" "Q7Z3E2" "Coiled-coil domain-containing protein 186 OS=Homo sapiens OX=9606 GN=CCDC186 PE=1 SV=2" "0.000" "False" "10.579" "3" "3" "3" "3" "898" "103.6" "6.27" "8.45" "3" "cell-cell signaling;transport;other biological processes" "ER/Golgi" "other molecular function" "" "55088" "ENSG00000165813" "CCDC186" "hsa:55088; Q2M2V6; Q3ZB81; Q6NS91; Q7RTP1; Q7Z3E2; Q8N117; Q8N3G3; Q8N6C2; Q9NWA3" "" "" "0" "0" "0.981" "1.047" "1.007" "0.999" "0.988" "0.915" "0.831" "0.946" "2.283" "180.9" "177.5" "189.4" "182.3" "180.7" "178.8" "165.6" "150.4" "171.1" "413.0" "" "" "" "" "" "" "" "" "" "" "160.5" "147.0" "165.2" "136.3" "150.7" "164.3" "140.0" "124.3" "156.9" "413.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088626010110122517" "False" "High" "IsMasterProtein" "Q9UJX6" "Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1" "0.000" "False" "10.579" "5" "5" "5" "5" "822" "93.8" "5.22" "10.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00888, Pf08672" "29882" "ENSG00000176248" "ANAPC2" "hsa:29882; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; Q9UJX6" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "0.967" "0.933" "1.020" "0.983" "0.866" "0.977" "0.834" "0.857" "1.478" "308.1" "298.0" "287.5" "314.2" "302.8" "266.8" "301.1" "257.0" "264.1" "455.4" "" "" "" "" "" "" "" "" "" "" "273.2" "246.9" "250.9" "235.0" "252.5" "245.1" "254.5" "212.4" "242.2" "455.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624689202228352756" "False" "High" "IsMasterProtein" "Q8IWJ2" "GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4" "0.000" "False" "10.571" "2" "5" "6" "3" "1684" "195.8" "5.14" "13.23" "5" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01465, Pf16704" "9648" "ENSG00000135968" "GCC2" "A6H8X8; hsa:9648; O15045; Q4ZG46; Q8IWJ2; Q8TDH3; Q9H2G8" "Signaling by ALK fusions and activated point mutants; Retrograde transport at the Trans-Golgi-Network" "Deregulation of Rab and Rab effector genes in bladder cancer" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2415988570574177896" "False" "High" "IsMasterProtein" "P13196" "5-aminolevulinate synthase, non-specific, mitochondrial OS=Homo sapiens OX=9606 GN=ALAS1 PE=1 SV=2" "0.000" "False" "10.538" "7" "5" "5" "5" "640" "70.5" "8.46" "12.30" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00155, Pf09029" "211" "ENSG00000023330" "ALAS1" "hsa:211; P13196" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; PPARA activates gene expression; Heme biosynthesis" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "8" "0" "0.967" "0.931" "0.961" "1.031" "1.013" "0.920" "0.959" "1.030" "1.247" "477.7" "462.0" "444.5" "459.1" "492.6" "483.9" "439.5" "457.9" "491.8" "595.5" "" "" "" "" "" "" "" "" "" "" "423.6" "382.7" "387.9" "343.3" "410.8" "444.5" "371.5" "378.5" "451.0" "595.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354971542348250461" "False" "High" "IsMasterProtein" "Q96BW9" "Phosphatidate cytidylyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TAMM41 PE=1 SV=2" "0.000" "False" "10.533" "4" "1" "2" "1" "452" "51.0" "7.94" "7.97" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf09139" "132001" "ENSG00000144559" "TAMM41" "B4DIY7; C9J2U4; hsa:132001; Q96BW9" "" "" "0" "0" "1.191" "1.042" "1.108" "1.161" "1.418" "1.297" "1.141" "0.988" "1.324" "45.9" "54.7" "47.8" "50.9" "53.3" "65.1" "59.5" "52.3" "45.4" "60.8" "" "" "" "" "" "" "" "" "" "" "40.7" "45.3" "41.7" "38.0" "44.4" "59.8" "50.3" "43.3" "41.6" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7226837977459101745" "False" "High" "IsMasterProtein" "P27701" "CD82 antigen OS=Homo sapiens OX=9606 GN=CD82 PE=1 SV=1" "0.000" "False" "10.533" "7" "1" "1" "1" "267" "29.6" "5.24" "5.97" "1" "" "plasma membrane;other membranes" "" "Pf00335" "3732" "ENSG00000085117" "CD82" "D3DQN6; E9PC70; hsa:3732; P27701; Q7Z2D4; Q7Z5N2" "" "16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "3" "0" "1.003" "0.872" "0.876" "1.051" "1.054" "1.036" "1.064" "1.467" "0.664" "83.2" "83.4" "72.5" "72.9" "87.5" "87.7" "86.2" "88.5" "122.1" "55.2" "" "" "" "" "" "" "" "" "" "" "73.8" "69.1" "63.3" "54.5" "72.9" "80.6" "72.9" "73.2" "112.0" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5758316461638693187" "False" "High" "IsMasterProtein" "Q05519" "Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1" "0.000" "False" "10.532" "6" "3" "3" "3" "484" "53.5" "10.52" "9.82" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00076" "9295" "ENSG00000116754" "SRSF11" "hsa:9295; Q05519; Q5T758; Q8IWE6" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "10.530" "3" "2" "3" "2" "537" "60.6" "4.84" "10.02" "2" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Regulation of the apoptosome activity" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "1.041" "1.069" "1.074" "1.057" "1.036" "1.135" "0.980" "0.950" "1.240" "182.3" "189.7" "194.8" "195.8" "192.7" "188.8" "206.8" "178.6" "173.1" "226.0" "" "" "" "" "" "" "" "" "" "" "161.6" "157.1" "170.0" "146.4" "160.7" "173.4" "174.8" "147.6" "158.8" "226.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6116188343313863326" "False" "High" "IsMasterProtein" "Q6P1L8" "Large ribosomal subunit protein uL14m OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" "0.000" "False" "10.525" "7" "1" "2" "1" "145" "15.9" "10.24" "7.32" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00238" "64928" "ENSG00000180992" "MRPL14" "B2R575; hsa:64928; Q6P1L8; Q96Q72" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.864" "0.874" "0.874" "0.885" "0.823" "1.038" "0.860" "0.865" "0.907" "227.5" "196.6" "198.8" "198.9" "201.2" "187.1" "236.1" "195.7" "196.7" "206.4" "" "" "" "" "" "" "" "" "" "" "201.7" "162.8" "173.5" "148.8" "167.8" "171.9" "199.6" "161.8" "180.4" "206.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8411894831205011543" "False" "High" "IsMasterProtein" "Q7L8J4" "SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1" "0.000" "False" "10.519" "8" "4" "4" "4" "393" "43.5" "5.77" "12.22" "4" "signal transduction" "other cell component" "enzyme regulator activity" "Pf05276" "80851" "ENSG00000175137" "SH3BP5L" "B4DQ94; hsa:80851; Q7L8J4; Q96FI5; Q9BQH8; Q9C0E3" "" "" "0" "0" "0.949" "0.867" "0.944" "0.853" "0.820" "0.819" "0.789" "0.865" "1.115" "546.4" "518.4" "473.9" "515.7" "466.3" "448.0" "447.4" "431.2" "472.9" "609.2" "" "" "" "" "" "" "" "" "" "" "484.5" "429.4" "413.5" "385.7" "388.8" "411.5" "378.1" "356.4" "433.7" "609.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049271637643204736" "False" "High" "IsMasterProtein" "Q96F63" "Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1" "0.000" "False" "10.517" "7" "2" "2" "2" "343" "38.9" "4.59" "8.37" "2" "" "nucleus" "" "Pf09747" "90324" "ENSG00000142039" "CCDC97" "hsa:90324; Q658N6; Q96F63; Q96IF3" "" "" "0" "0" "1.159" "1.098" "1.003" "1.079" "0.978" "1.039" "0.998" "0.922" "1.777" "108.2" "125.5" "118.8" "108.5" "116.7" "105.9" "112.5" "108.0" "99.7" "192.3" "" "" "" "" "" "" "" "" "" "" "96.0" "103.9" "103.6" "81.1" "97.3" "97.3" "95.0" "89.3" "91.5" "192.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-631503824976752333" "False" "High" "IsMasterProtein" "Q9BYD2" "Large ribosomal subunit protein bL9m OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" "0.000" "False" "10.516" "11" "2" "2" "2" "267" "30.2" "10.08" "6.70" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01281" "65005" "ENSG00000143436" "MRPL9" "B2RD99; hsa:65005; Q5SZR2; Q9BSW8; Q9BYD2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.187" "1.218" "1.258" "1.559" "1.087" "1.333" "1.239" "1.039" "2.037" "27.6" "32.7" "33.6" "34.7" "43.0" "30.0" "36.7" "34.2" "28.6" "56.1" "" "" "" "" "" "" "" "" "" "" "24.4" "27.1" "29.3" "25.9" "35.8" "27.5" "31.1" "28.2" "26.3" "56.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "376281410555249272" "False" "High" "IsMasterProtein" "O75592" "E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4" "0.000" "False" "10.512" "1" "3" "3" "3" "4678" "513.3" "7.02" "10.16" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf03256, Pf08005, Pf13540" "23077" "ENSG00000005810" "MYCBP2" "A6NJC6; O75592; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4" "" "3q29 copy number variation syndrome" "1" "0" "1.063" "0.948" "0.940" "0.873" "1.041" "1.021" "0.821" "1.091" "2.439" "107.5" "114.3" "101.9" "101.1" "93.9" "111.9" "109.7" "88.2" "117.3" "262.2" "" "" "" "" "" "" "" "" "" "" "95.3" "94.7" "88.9" "75.6" "78.3" "102.8" "92.7" "72.9" "107.6" "262.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "High" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.000" "False" "10.512" "4" "3" "4" "2" "747" "85.1" "7.69" "11.72" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "" "5" "0" "1.178" "1.041" "0.901" "1.001" "0.825" "1.317" "0.303" "1.260" "9.779" "15.3" "18.1" "16.0" "13.8" "15.4" "12.6" "20.2" "4.6" "19.3" "150.0" "" "" "" "" "" "" "" "" "" "" "13.6" "15.0" "13.9" "10.3" "12.8" "11.6" "17.1" "3.8" "17.7" "150.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2576441029290344386" "False" "High" "IsMasterProtein" "Q03468" "DNA excision repair protein ERCC-6 OS=Homo sapiens OX=9606 GN=ERCC6 PE=1 SV=1" "0.000" "False" "10.512" "2" "2" "2" "2" "1493" "168.3" "8.09" "9.03" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "2074" "ENSG00000225830" "ERCC6" "D3DX94; E7EV46; hsa:2074; Q03468; Q5W0L9" "B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "12" "0" "1.051" "0.917" "1.189" "0.960" "0.815" "1.139" "0.906" "0.956" "0.833" "117.4" "123.4" "107.7" "139.6" "112.7" "95.7" "133.8" "106.4" "112.3" "97.8" "" "" "" "" "" "" "" "" "" "" "104.1" "102.2" "94.0" "104.4" "94.0" "87.9" "113.1" "87.9" "103.0" "97.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2083530276327625921" "False" "High" "IsMasterProtein" "Q9BUW7" "Bublin coiled-coil protein OS=Homo sapiens OX=9606 GN=BBLN PE=1 SV=1" "0.000" "False" "10.508" "19" "1" "2" "1" "83" "9.0" "4.22" "8.45" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "Pf03670" "79095" "ENSG00000171159" "BBLN" "hsa:79095; Q5SYV8; Q9BUW7; Q9Y3F7" "" "" "0" "0" "1.088" "0.957" "1.113" "1.049" "0.906" "1.293" "1.109" "1.131" "0.577" "96.5" "105.0" "92.3" "107.3" "101.2" "87.4" "124.8" "107.0" "109.2" "55.7" "" "" "" "" "" "" "" "" "" "" "85.6" "86.9" "80.5" "80.3" "84.4" "80.3" "105.5" "88.5" "100.1" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2315597211980714734" "False" "High" "IsMasterProtein" "Q9BRQ8" "Ferroptosis suppressor protein 1 OS=Homo sapiens OX=9606 GN=AIFM2 PE=1 SV=1" "0.000" "False" "10.497" "9" "4" "4" "4" "373" "40.5" "9.11" "12.09" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07992" "84883" "ENSG00000042286" "AIFM2" "B3KXI0; hsa:84883; Q63Z39; Q9BRQ8" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "Apoptosis modulation and signaling; Ferroptosis; Urotensin-II-mediated signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263774820605261131" "False" "High" "IsMasterProtein" "Q9BTK6" "PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=PAGR1 PE=1 SV=1" "0.000" "False" "10.431" "9" "2" "4" "2" "254" "27.7" "4.46" "17.69" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf15364" "79447" "ENSG00000280789" "PAGR1" "A2ICR6; hsa:79447; Q9BTK6" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of WDR5-containing histone-modifying complexes" "16p11.2 proximal deletion syndrome; Kleefstra syndrome" "4" "0" "0.885" "0.915" "0.917" "0.968" "0.856" "0.756" "0.738" "0.717" "0.613" "225.9" "199.9" "206.8" "207.1" "218.7" "193.4" "170.7" "166.7" "161.9" "138.6" "" "" "" "" "" "" "" "" "" "" "200.3" "165.6" "180.4" "154.9" "182.3" "177.6" "144.3" "137.8" "148.5" "138.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6599360429670756188" "False" "High" "IsMasterProtein" "Q92902" "BLOC-3 complex member HPS1 OS=Homo sapiens OX=9606 GN=HPS1 PE=1 SV=2" "0.000" "False" "10.429" "4" "3" "3" "3" "700" "79.2" "5.91" "11.02" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf19036, Pf19037, Pf19038" "3257" "ENSG00000107521" "HPS1" "A8MRT2; O15402; O15502; Q5TAA3; Q8WXE5; Q92902" "RAB GEFs exchange GTP for GDP on RABs" "IL-18 signaling pathway" "2" "0" "1.262" "1.022" "1.242" "1.138" "1.108" "1.147" "1.095" "1.027" "1.029" "386.5" "487.6" "394.9" "479.8" "439.7" "428.1" "443.4" "423.2" "397.1" "397.7" "" "" "" "" "" "" "" "" "" "" "342.7" "403.9" "344.6" "358.9" "366.7" "393.3" "374.7" "349.8" "364.2" "397.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2662699924812854810" "False" "High" "IsMasterProtein" "Q9P219" "Protein Daple OS=Homo sapiens OX=9606 GN=CCDC88C PE=1 SV=3" "0.000" "False" "10.399" "1" "3" "3" "3" "2028" "228.1" "6.23" "8.68" "3" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "440193" "ENSG00000015133" "CCDC88C" "hsa:440193; Q69YK1; Q7L1M2; Q86SX7; Q8IYG8; Q9P219" "Negative regulation of TCF-dependent signaling by DVL-interacting proteins" "Ectoderm differentiation; Ectoderm differentiation" "3" "0" "1.181" "0.998" "1.119" "0.918" "0.810" "0.868" "0.630" "1.048" "4.572" "104.7" "123.6" "104.5" "117.2" "96.1" "84.8" "90.9" "65.9" "109.7" "478.6" "" "" "" "" "" "" "" "" "" "" "92.8" "102.4" "91.2" "87.6" "80.2" "77.9" "76.8" "54.5" "100.7" "478.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5517326746891322777" "False" "High" "IsMasterProtein" "Q9H2P0" "Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1" "0.000" "False" "10.396" "2" "2" "2" "2" "1102" "123.5" "7.34" "7.44" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00046, Pf19627" "23394" "ENSG00000101126" "ADNP" "E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34" "" "" "0" "0" "1.107" "0.963" "1.013" "0.961" "1.018" "0.912" "0.740" "0.927" "5.956" "114.6" "126.8" "110.3" "116.1" "110.1" "116.6" "104.5" "84.8" "106.2" "682.3" "" "" "" "" "" "" "" "" "" "" "101.6" "105.0" "96.3" "86.8" "91.8" "107.1" "88.3" "70.1" "97.4" "682.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5970441865792546005" "False" "High" "IsMasterProtein" "P04920" "Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4" "0.000" "False" "10.392" "2" "2" "2" "2" "1241" "136.9" "6.29" "7.74" "2" "transport;developmental processes;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00955, Pf07565" "6522" "ENSG00000164889" "SLC4A2" "B2R6T0; B4DIT0; D3DX05; F8W682; hsa:6522; P04920; Q45EY5; Q969L3" "Bicarbonate transporters" "Proximal tubule transport" "2" "0" "1.122" "1.086" "1.158" "1.079" "1.003" "1.158" "0.825" "1.174" "1.094" "47.5" "53.2" "51.5" "54.9" "51.2" "47.6" "54.9" "39.2" "55.7" "51.9" "" "" "" "" "" "" "" "" "" "" "42.1" "44.1" "45.0" "41.1" "42.7" "43.7" "46.4" "32.4" "51.1" "51.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9163044576809599647" "False" "High" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "0.000" "False" "10.388" "28" "3" "3" "3" "133" "15.2" "5.80" "10.31" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "4" "0" "0.986" "0.816" "1.285" "0.951" "0.745" "1.340" "0.972" "1.061" "1.798" "469.6" "462.9" "383.4" "603.4" "446.6" "350.0" "629.0" "456.3" "498.3" "844.3" "" "" "" "" "" "" "" "" "" "" "416.4" "383.4" "334.5" "451.3" "372.4" "321.5" "531.6" "377.1" "457.0" "844.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370304273166594920" "False" "High" "IsMasterProtein" "O94906" "Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1" "0.000" "False" "10.365" "5" "4" "4" "4" "941" "106.9" "8.25" "9.01" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06424, Pf13181, Pf14559" "24148" "ENSG00000101161" "PRPF6" "B2RAR5; B3KMC6; hsa:24148; O94906; O95109; Q5VXS5; Q9H3Z1; Q9H4T9; Q9H4U8; Q9NTE6" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.925" "0.874" "0.952" "0.923" "0.893" "0.821" "0.784" "0.891" "1.778" "225.3" "208.5" "196.9" "214.6" "208.0" "201.2" "185.0" "176.7" "200.7" "400.7" "" "" "" "" "" "" "" "" "" "" "199.8" "172.7" "171.8" "160.5" "173.4" "184.9" "156.4" "146.0" "184.1" "400.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2644989191906863874" "False" "High" "IsMasterProtein" "Q6ZSZ5" "Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4" "0.000" "False" "10.364" "3" "3" "3" "3" "1361" "151.5" "6.33" "10.77" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00621, Pf17838" "23370" "ENSG00000104880" "ARHGEF18" "A8MV62; B5ME81; hsa:23370; I3L1I5; O60274; Q6DD92; Q6ZSZ5" "RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "" "5" "0" "1.064" "1.032" "1.175" "0.998" "0.932" "1.071" "0.976" "0.995" "2.077" "117.7" "125.2" "121.4" "138.3" "117.5" "109.7" "126.0" "114.9" "117.1" "244.4" "" "" "" "" "" "" "" "" "" "" "104.4" "103.7" "106.0" "103.4" "98.0" "100.8" "106.5" "94.9" "107.4" "244.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4457923418212220439" "False" "High" "IsMasterProtein" "O60499" "Syntaxin-10 OS=Homo sapiens OX=9606 GN=STX10 PE=1 SV=1" "0.000" "False" "10.346" "7" "2" "3" "2" "249" "28.1" "4.89" "11.24" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf05739, Pf09177" "8677" "ENSG00000104915" "STX10" "A6NC41; hsa:8677; O60499; Q6IAP4; Q96AE8" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.105" "1.034" "1.178" "1.049" "1.105" "1.191" "1.056" "0.992" "1.067" "254.6" "281.5" "263.4" "300.0" "267.1" "281.3" "303.4" "268.9" "252.6" "271.7" "" "" "" "" "" "" "" "" "" "" "225.8" "233.2" "229.8" "224.3" "222.7" "258.4" "256.4" "222.3" "231.7" "271.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4319087482350833745" "False" "High" "IsMasterProtein" "Q96F10" "Thialysine N-epsilon-acetyltransferase OS=Homo sapiens OX=9606 GN=SAT2 PE=1 SV=1" "0.000" "False" "10.339" "14" "3" "3" "3" "170" "19.1" "6.04" "10.30" "3" "other metabolic processes" "other cell component" "other molecular function" "Pf00583" "112483" "ENSG00000141504" "SAT2" "hsa:112483; Q96F10" "" "Ferroptosis" "1" "0" "1.005" "0.940" "1.024" "0.960" "0.932" "1.129" "1.074" "0.922" "0.905" "360.8" "362.7" "339.3" "369.5" "346.5" "336.3" "407.5" "387.6" "332.6" "326.6" "" "" "" "" "" "" "" "" "" "" "320.0" "300.4" "296.0" "276.3" "289.0" "309.0" "344.4" "320.4" "305.0" "326.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772258242304102193" "False" "High" "IsMasterProtein" "Q9BQE5" "Apolipoprotein L2 OS=Homo sapiens OX=9606 GN=APOL2 PE=1 SV=2" "0.000" "False" "10.324" "6" "2" "2" "2" "337" "37.1" "6.74" "7.99" "2" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf05461" "23780" "ENSG00000128335" "APOL2" "B0QYK7; hsa:23780; O95915; Q59GW9; Q5TH96; Q969T6; Q9BQE5; Q9BT28; Q9UGT1; Q9UH10" "" "" "0" "0" "1.014" "0.916" "0.935" "0.965" "0.912" "1.139" "0.962" "1.005" "2.858" "522.3" "529.7" "478.6" "488.2" "504.2" "476.5" "595.0" "502.3" "525.1" "1492.7" "" "" "" "" "" "" "" "" "" "" "463.2" "438.8" "417.6" "365.1" "420.4" "437.7" "502.9" "415.2" "481.6" "1492.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028441251658952013" "False" "High" "IsMasterProtein" "Q9H7L9" "Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens OX=9606 GN=SUDS3 PE=1 SV=2" "0.000" "False" "10.317" "6" "2" "2" "2" "328" "38.1" "5.66" "9.05" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08598" "64426" "ENSG00000111707" "SUDS3" "hsa:64426; Q4KMQ5; Q8N6H0; Q9H7L9; Q9H8D2" "Ub-specific processing proteases; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Potential therapeutics for SARS" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502285001895834817" "False" "High" "IsMasterProtein" "Q99638" "Cell cycle checkpoint control protein RAD9A OS=Homo sapiens OX=9606 GN=RAD9A PE=1 SV=1" "0.000" "False" "10.292" "7" "3" "3" "3" "391" "42.5" "5.66" "11.10" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04139" "5883" "ENSG00000172613" "RAD9A" "B2RCZ8; hsa:5883; Q6FI29; Q96C41; Q99638" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; NF1 copy number variation syndrome ; DNA damage response" "14" "0" "0.953" "0.935" "0.925" "1.053" "1.001" "1.057" "1.036" "0.813" "0.623" "430.8" "410.4" "403.0" "398.4" "453.7" "431.1" "455.5" "446.2" "350.3" "268.5" "" "" "" "" "" "" "" "" "" "" "382.0" "339.9" "351.7" "298.0" "378.3" "396.0" "385.0" "368.8" "321.3" "268.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3550614013973356196" "False" "High" "IsMasterProtein" "Q9GZX9" "Twisted gastrulation protein homolog 1 OS=Homo sapiens OX=9606 GN=TWSG1 PE=1 SV=1" "0.000" "False" "10.291" "11" "2" "2" "2" "223" "25.0" "5.34" "8.53" "2" "developmental processes;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf04668" "57045" "ENSG00000128791" "TWSG1" "B2RE08; D3DUH9; hsa:57045; Q8NBI7; Q96K46; Q9GZX9" "" "Mesodermal commitment pathway; Mesodermal commitment pathway" "2" "0" "1.125" "1.040" "1.081" "1.105" "1.179" "1.238" "1.178" "1.262" "0.608" "263.1" "296.0" "273.6" "284.6" "290.7" "310.2" "325.7" "310.0" "332.0" "160.1" "" "" "" "" "" "" "" "" "" "" "233.3" "245.2" "238.8" "212.8" "242.4" "285.0" "275.3" "256.2" "304.5" "160.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "High" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.000" "False" "10.281" "12" "2" "2" "2" "182" "20.1" "8.02" "8.98" "2" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "0.995" "1.051" "1.070" "1.076" "1.103" "1.119" "1.157" "0.953" "0.702" "293.3" "292.0" "308.2" "313.7" "315.6" "323.4" "328.3" "339.4" "279.4" "205.8" "" "" "" "" "" "" "" "" "" "" "260.1" "241.8" "268.9" "234.6" "263.1" "297.1" "277.5" "280.6" "256.2" "205.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1638288113087067454" "False" "High" "IsMasterProtein" "Q9NQG6" "Mitochondrial dynamics protein MIEF1 OS=Homo sapiens OX=9606 GN=MIEF1 PE=1 SV=1" "0.000" "False" "10.278" "6" "3" "3" "3" "463" "51.3" "7.64" "10.67" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf20266, Pf21297" "54471" "ENSG00000100335" "MIEF1" "hsa:54471; Q7L890; Q9BUI3; Q9NQG6" "" "" "0" "0" "1.160" "1.042" "1.130" "1.097" "0.989" "1.107" "1.092" "1.020" "1.102" "152.4" "176.8" "158.8" "172.3" "167.2" "150.7" "168.7" "166.5" "155.5" "167.9" "" "" "" "" "" "" "" "" "" "" "135.2" "146.5" "138.5" "128.8" "139.4" "138.4" "142.6" "137.6" "142.6" "167.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845419377566949929" "False" "High" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.000" "False" "10.261" "12" "2" "4" "2" "147" "16.7" "7.80" "12.59" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Proteasome degradation" "13" "0" "1.062" "0.986" "0.980" "1.037" "0.971" "1.014" "1.001" "1.056" "1.449" "455.8" "484.0" "449.6" "446.7" "472.5" "442.8" "462.3" "456.2" "481.5" "660.4" "" "" "" "" "" "" "" "" "" "" "404.2" "401.0" "392.3" "334.1" "394.0" "406.8" "390.7" "377.1" "441.6" "660.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2484581201426293261" "False" "High" "IsMasterProtein" "Q8NB25" "Protein FAM184A OS=Homo sapiens OX=9606 GN=FAM184A PE=1 SV=3" "0.000" "False" "10.233" "2" "2" "2" "2" "1140" "132.9" "5.83" "7.74" "2" "" "cytoskeleton;other cell component" "" "Pf15665" "79632" "ENSG00000111879" "FAM184A" "B9DI75; F8W8D6; hsa:79632; Q5TBS9; Q7Z323; Q8NB25; Q96GY8; Q9H0J8; Q9H851" "" "" "0" "0" "1.035" "1.067" "1.061" "1.002" "1.064" "0.842" "0.918" "0.918" "0.884" "219.5" "227.2" "234.2" "232.9" "219.9" "233.6" "184.8" "201.4" "201.6" "194.1" "" "" "" "" "" "" "" "" "" "" "194.7" "188.2" "204.3" "174.2" "183.4" "214.6" "156.2" "166.5" "184.9" "194.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482571623851624299" "False" "High" "IsMasterProtein" "Q7Z6M3" "Allergin-1 OS=Homo sapiens OX=9606 GN=MILR1 PE=1 SV=2" "0.000" "False" "10.202" "3" "2" "3" "2" "343" "38.7" "7.77" "11.17" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13895, Pf17736" "284021" "ENSG00000271605" "MILR1" "A1L458; B4DUS1; B7ZM50; B9EGN0; D6RUW6; D6RUW8; hsa:284021; Q7Z6M3" "" "" "0" "0" "1.070" "1.010" "0.945" "1.013" "1.064" "0.948" "0.984" "1.001" "0.530" "479.8" "513.2" "484.6" "453.6" "485.9" "510.6" "454.8" "472.2" "480.1" "254.2" "" "" "" "" "" "" "" "" "" "" "425.4" "425.1" "422.8" "339.2" "405.1" "469.1" "384.4" "390.3" "440.3" "254.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4493911830020970266" "False" "High" "IsMasterProtein" "Q9BQE9" "B-cell CLL/lymphoma 7 protein family member B OS=Homo sapiens OX=9606 GN=BCL7B PE=1 SV=1" "0.000" "False" "10.141" "16" "3" "3" "1" "202" "22.2" "4.75" "11.18" "3" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf04714" "9275" "ENSG00000106635" "BCL7B" "A8K226; C9JWD3; D3DXF0; hsa:9275; O43769; Q13845; Q6ZW75; Q9BQE9" "" "7q11.23 copy number variation syndrome" "1" "0" "1.115" "0.948" "1.312" "1.184" "1.132" "1.285" "0.976" "1.092" "0.866" "40.6" "45.3" "38.5" "53.3" "48.1" "45.9" "52.2" "39.6" "44.3" "35.2" "" "" "" "" "" "" "" "" "" "" "36.0" "37.5" "33.6" "39.8" "40.1" "42.2" "44.1" "32.7" "40.7" "35.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6065007746744177820" "False" "High" "IsMasterProtein" "Q9ULZ2" "Signal-transducing adaptor protein 1 OS=Homo sapiens OX=9606 GN=STAP1 PE=1 SV=1" "0.000" "False" "10.131" "8" "3" "4" "3" "295" "34.3" "7.77" "13.73" "3" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00169" "26228" "ENSG00000035720" "STAP1" "B2R980; hsa:26228; Q9ULZ2" "" "" "0" "0" "0.806" "1.067" "0.750" "0.707" "0.802" "0.933" "0.593" "1.279" "4.356" "337.3" "271.7" "360.0" "253.0" "238.4" "270.3" "314.8" "199.9" "431.3" "1469.1" "" "" "" "" "" "" "" "" "" "" "299.1" "225.1" "314.1" "189.2" "198.8" "248.3" "266.0" "165.2" "395.5" "1469.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5807037256963766302" "False" "High" "IsMasterProtein" "Q9H0F7" "ADP-ribosylation factor-like protein 6 OS=Homo sapiens OX=9606 GN=ARL6 PE=1 SV=1" "0.000" "False" "10.127" "17" "3" "3" "3" "186" "21.1" "8.54" "11.05" "3" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00025" "84100" "ENSG00000113966" "ARL6" "A8KA93; D3DN31; hsa:84100; Q9H0F7" "BBSome-mediated cargo-targeting to cilium" "Ciliopathies; Bardet-Biedl syndrome" "3" "0" "1.056" "0.929" "0.939" "1.000" "1.006" "1.107" "0.999" "1.070" "3.422" "388.5" "410.4" "360.9" "364.8" "388.4" "390.8" "430.1" "388.1" "415.5" "1329.5" "" "" "" "" "" "" "" "" "" "" "344.5" "340.0" "314.9" "272.8" "323.9" "359.0" "363.5" "320.8" "381.1" "1329.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "High" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.000" "False" "10.101" "4" "3" "3" "3" "904" "102.3" "11.84" "11.32" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "7" "0" "0.970" "0.871" "0.987" "0.949" "0.999" "1.015" "1.010" "1.020" "1.149" "406.9" "394.6" "354.4" "401.7" "386.2" "406.4" "412.8" "411.1" "415.1" "467.4" "" "" "" "" "" "" "" "" "" "" "360.8" "326.9" "309.2" "300.4" "322.0" "373.3" "348.9" "339.8" "380.7" "467.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463882674882175167" "False" "High" "IsMasterProtein" "Q5NDL2" "EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1" "0.000" "False" "10.086" "5" "3" "3" "3" "527" "62.0" "7.05" "8.67" "3" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf04577" "285203" "ENSG00000163378" "EOGT" "A8K2U1; B4DFH5; hsa:285203; L7X1M5; Q5NDL2; Q6MZY0; Q6P985; Q6ZTV0" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.902" "0.750" "1.131" "0.854" "0.673" "1.141" "0.950" "0.894" "0.765" "625.0" "563.4" "468.5" "706.9" "533.4" "420.9" "712.9" "593.6" "558.5" "477.9" "" "" "" "" "" "" "" "" "" "" "554.2" "466.7" "408.8" "528.6" "444.8" "386.6" "602.5" "490.7" "512.2" "477.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8617908927917494365" "False" "High" "IsMasterProtein" "O14639" "Actin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=ABLIM1 PE=1 SV=3" "0.000" "False" "10.072" "4" "3" "3" "3" "778" "87.6" "8.59" "9.54" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf02209, Pf16182" "3983" "ENSG00000099204" "ABLIM1" "A6NI16; A6NJ06; A8MXA9; B3KVH2; hsa:3983; O14639; Q15039; Q5JVV1; Q5JVV2; Q5T6N2; Q5T6N3; Q5T6N5; Q68CQ9; Q9BUP1" "DCC mediated attractive signaling" "Male infertility" "2" "0" "1.016" "0.883" "0.920" "1.117" "1.046" "1.035" "0.944" "0.959" "0.882" "170.6" "173.3" "150.7" "157.0" "190.5" "178.4" "176.5" "161.0" "163.6" "150.5" "" "" "" "" "" "" "" "" "" "" "151.3" "143.6" "131.5" "117.4" "158.9" "163.9" "149.2" "133.1" "150.0" "150.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5885254063310961994" "False" "High" "IsMasterProtein" "Q6NXT1" "Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2" "0.000" "False" "10.069" "10" "3" "3" "3" "300" "32.5" "6.28" "9.19" "3" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf12796" "129138" "ENSG00000100124" "ANKRD54" "hsa:129138; Q6NXT1; Q6ZSB1; Q9UGV1" "" "" "0" "0" "1.033" "1.052" "0.993" "1.048" "0.880" "1.013" "0.903" "1.031" "2.093" "381.3" "393.9" "400.9" "378.8" "399.4" "335.4" "386.4" "344.2" "393.0" "797.9" "" "" "" "" "" "" "" "" "" "" "338.1" "326.3" "349.8" "283.3" "333.0" "308.1" "326.6" "284.5" "360.5" "797.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2880199082589634412" "False" "High" "IsMasterProtein" "P30281" "G1/S-specific cyclin-D3 OS=Homo sapiens OX=9606 GN=CCND3 PE=1 SV=2" "0.000" "False" "10.069" "13" "3" "3" "3" "292" "32.5" "7.06" "9.49" "3" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "896" "ENSG00000112576" "CCND3" "B2RD63; B3KQ22; E9PAS4; E9PB36; hsa:896; P30281; Q5T8J0; Q6FG62; Q96F49" "Regulation of RUNX1 Expression and Activity; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Drug-mediated inhibition of CDK4/CDK6 activity" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Retinoblastoma gene in cancer; Focal adhesion; Overview of nanoparticle effects; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Measles virus infection; Pleural mesothelioma; JAK-STAT signaling in the regulation of beta cells; DNA damage response; DNA damage response (only ATM dependent)" "24" "0" "1.037" "1.057" "1.104" "1.075" "1.049" "0.967" "0.994" "1.045" "1.228" "224.3" "232.6" "237.2" "247.6" "241.2" "235.4" "216.9" "222.9" "234.4" "275.4" "" "" "" "" "" "" "" "" "" "" "198.9" "192.7" "206.9" "185.2" "201.1" "216.2" "183.3" "184.2" "215.0" "275.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5023215591343920566" "False" "High" "IsMasterProtein" "Q12768" "WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1" "0.000" "False" "10.050" "3" "3" "3" "3" "1159" "134.2" "6.98" "8.27" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf10266" "9897" "ENSG00000164961" "WASHC5" "A8K4R7; hsa:9897; Q12768; Q3KQX5; Q8TBQ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4333754145708475207" "False" "High" "IsMasterProtein" "Q9UKT8" "F-box/WD repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=FBXW2 PE=1 SV=2" "0.000" "False" "10.020" "7" "3" "3" "3" "454" "51.5" "6.58" "10.93" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00400, Pf00646" "26190" "ENSG00000119402" "FBXW2" "B3KRL8; hsa:26190; Q4VXH2; Q7Z4V6; Q8WV51; Q9HA09; Q9UKA3; Q9UKT8" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "Wnt signaling pathway and pluripotency" "4" "0" "1.020" "1.000" "1.090" "1.032" "1.012" "1.140" "1.024" "0.953" "0.807" "320.3" "326.8" "320.4" "349.0" "330.6" "324.0" "365.1" "327.9" "305.1" "258.3" "" "" "" "" "" "" "" "" "" "" "284.0" "270.7" "279.5" "261.0" "275.7" "297.6" "308.6" "271.0" "279.8" "258.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4906938189869504573" "False" "High" "IsMasterProtein" "Q6GQQ9" "OTU domain-containing protein 7B OS=Homo sapiens OX=9606 GN=OTUD7B PE=1 SV=1" "0.000" "False" "9.989" "3" "2" "2" "2" "843" "92.5" "6.71" "6.32" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01754, Pf02338, Pf14555" "56957" "ENSG00000264522" "OTUD7B" "B7Z643; D3DUZ8; hsa:56957; Q5SZ60; Q6GQQ9; Q8WWA7; Q9NQ53; Q9UFF4" "Ovarian tumor domain proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "TNF-alpha signaling pathway; Warburg effect modulated by deubiquitinating enzymes and their substrates" "6" "0" "0.945" "0.920" "1.027" "0.790" "0.965" "0.891" "0.589" "0.902" "3.089" "34.5" "32.7" "31.8" "35.5" "27.3" "33.3" "30.8" "20.4" "31.2" "106.7" "" "" "" "" "" "" "" "" "" "" "30.6" "27.0" "27.7" "26.5" "22.7" "30.6" "26.0" "16.8" "28.6" "106.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622932999208517122" "False" "High" "IsMasterProtein" "Q96HR8" "H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2" "0.000" "False" "9.989" "5" "3" "3" "3" "494" "53.7" "4.87" "11.11" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04410" "92345" "ENSG00000145414" "NAF1" "D3DP28; E9PAZ2; hsa:92345; Q96HR8" "" "" "0" "0" "0.825" "0.907" "0.855" "0.911" "0.989" "0.944" "0.879" "0.966" "1.179" "581.3" "479.9" "527.5" "496.9" "529.3" "575.0" "549.0" "511.2" "561.3" "685.4" "" "" "" "" "" "" "" "" "" "" "515.5" "397.5" "460.3" "371.6" "441.4" "528.2" "464.0" "422.5" "514.8" "685.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7274845657669851" "False" "High" "IsMasterProtein" "Q9BQE6" "LBH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LBHD1 PE=1 SV=3" "0.000" "False" "9.973" "12" "3" "3" "3" "289" "31.5" "4.60" "8.48" "3" "other biological processes" "nucleus" "" "Pf15317" "79081" "ENSG00000162194" "LBHD1" "hsa:79081; Q96NA4; Q9BQE6" "" "" "0" "0" "0.867" "1.025" "1.159" "1.024" "1.046" "0.905" "1.081" "1.234" "0.772" "135.7" "117.7" "139.1" "157.2" "138.9" "142.0" "122.8" "146.6" "167.4" "104.7" "" "" "" "" "" "" "" "" "" "" "120.3" "97.5" "121.4" "117.6" "115.9" "130.4" "103.8" "121.2" "153.5" "104.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1059597510691601" "False" "High" "IsMasterProtein" "B2RBV5" "MORF4 family associated protein 1 like 2 OS=Homo sapiens OX=9606 GN=MRFAP1L2 PE=1 SV=1" "0.000" "False" "9.950" "32" "4" "5" "4" "119" "13.4" "8.22" "15.42" "4" "other biological processes" "" "" "Pf15155" "" "" "MRFAP1L2" "B2RBV5" "" "" "0" "0" "0.962" "0.921" "1.138" "1.005" "0.873" "1.199" "1.036" "1.173" "0.735" "168.6" "162.3" "155.4" "191.9" "169.5" "147.3" "202.1" "174.8" "197.7" "124.0" "" "" "" "" "" "" "" "" "" "" "149.5" "134.4" "135.6" "143.5" "141.4" "135.3" "170.8" "144.5" "181.4" "124.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1874471011183671858" "False" "High" "IsMasterProtein" "Q16670" "Zinc finger and SCAN domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZSCAN26 PE=1 SV=2" "0.000" "False" "9.948" "7" "3" "3" "3" "478" "55.2" "8.06" "10.82" "3" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7741" "ENSG00000197062" "ZSCAN26" "hsa:7741; Q16670; Q5JPG4; Q7Z3Q6; Q96A17" "" "" "0" "0" "0.987" "0.872" "0.977" "0.939" "0.943" "1.289" "0.886" "0.967" "0.798" "247.2" "244.0" "215.5" "241.5" "232.2" "233.1" "318.7" "219.1" "239.0" "197.2" "" "" "" "" "" "" "" "" "" "" "219.2" "202.2" "188.0" "180.6" "193.6" "214.1" "269.4" "181.1" "219.2" "197.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638301692080516805" "False" "High" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "0.000" "False" "9.948" "6" "4" "5" "4" "575" "61.6" "6.95" "15.24" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Regulation of HSF1-mediated heat shock response" "Cell interactions of the pancreatic cancer microenvironment" "2" "0" "0.851" "0.750" "0.732" "0.780" "0.768" "0.739" "0.802" "0.918" "0.409" "179.2" "152.5" "134.3" "131.2" "139.7" "137.5" "132.5" "143.7" "164.4" "73.3" "" "" "" "" "" "" "" "" "" "" "158.9" "126.3" "117.2" "98.1" "116.5" "126.3" "112.0" "118.8" "150.8" "73.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3143696315815793188" "False" "High" "IsMasterProtein" "Q8WXH0" "Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3" "0.000" "False" "9.927" "0" "4" "5" "4" "6885" "795.9" "5.36" "17.15" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23224" "ENSG00000054654" "SYNE2" "B4DND7; B4DPR6; I6XXQ5; Q540G1; Q86YP9; Q8N1S3; Q8NF49; Q8TER7; Q8WWW3; Q8WWW4; Q8WWW5; Q8WXH0; Q8WXH1; Q9NU50; Q9UFQ4; Q9Y2L4; Q9Y4R1" "Meiotic synapsis" "Ovarian infertility; Rett syndrome; Envelope proteins and their potential roles in EDMD physiopathology" "4" "0" "0.970" "1.051" "0.911" "0.928" "0.940" "0.935" "1.030" "0.936" "0.580" "600.6" "582.3" "631.3" "547.1" "557.5" "564.4" "561.7" "618.7" "561.9" "348.1" "" "" "" "" "" "" "" "" "" "" "532.6" "482.3" "550.8" "409.2" "464.9" "518.4" "474.7" "511.4" "515.3" "348.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1783792033634386114" "False" "High" "IsMasterProtein" "Q8N7H5" "RNA polymerase II-associated factor 1 homolog OS=Homo sapiens OX=9606 GN=PAF1 PE=1 SV=2" "0.000" "False" "9.916" "9" "3" "4" "3" "531" "59.9" "4.63" "7.77" "3" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03985" "54623" "ENSG00000006712" "PAF1" "hsa:54623; M0QX35; O75239; Q8N7H5; Q9H166; Q9NUU9" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "1.050" "1.103" "0.872" "0.749" "0.855" "0.869" "0.770" "0.901" "2.192" "41.5" "43.6" "45.8" "36.2" "31.1" "35.5" "36.1" "31.9" "37.4" "91.0" "" "" "" "" "" "" "" "" "" "" "36.8" "36.1" "39.9" "27.1" "25.9" "32.6" "30.5" "26.4" "34.3" "91.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779198879907914861" "False" "High" "IsMasterProtein" "P62328" "Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2" "0.000" "False" "9.913" "45" "3" "25" "1" "44" "5.1" "5.06" "63.16" "3" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01290" "7114" "ENSG00000205542" "TMSB4X" "hsa:7114; P01253; P01254; P62328; Q546P5; Q63576; Q9UE55" "Platelet degranulation" "Genes targeted by miRNAs in adipocytes; VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Regulation of actin cytoskeleton" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7873984446358378188" "False" "High" "IsMasterProtein" "Q6UUV9" "CREB-regulated transcription coactivator 1 OS=Homo sapiens OX=9606 GN=CRTC1 PE=1 SV=2" "0.000" "False" "9.907" "4" "2" "2" "2" "634" "67.3" "6.05" "8.03" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "23373" "ENSG00000105662" "CRTC1" "A6NMG5; hsa:23373; O75114; Q6UUV9; Q6Y3A3; Q7LDZ2; Q8IUL3; Q8IZ34; Q8IZL1; Q8N6W3; Q96AI8; Q9H801" "Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway" "5" "0" "0.961" "1.003" "0.979" "1.041" "1.043" "1.034" "1.038" "1.071" "0.657" "334.3" "321.3" "335.4" "327.2" "347.9" "348.8" "345.6" "347.0" "358.0" "219.7" "" "" "" "" "" "" "" "" "" "" "296.5" "266.2" "292.7" "244.7" "290.1" "320.4" "292.1" "286.8" "328.3" "219.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1703927075416448593" "False" "High" "IsMasterProtein" "P07477" "Serine protease 1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1" "0.000" "False" "9.899" "11" "2" "9" "1" "247" "26.5" "6.51" "20.09" "2" "cell organization and biogenesis;protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "5644" "ENSG00000204983; ENSG00000274247" "PRSS1" "A1A509; A6NJ71; B2R5I5; hsa:5644; P07477; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7" "Uptake of dietary cobalamins into enterocytes; Activation of Matrix Metalloproteinases" "" "2" "0" "0.895" "0.839" "0.952" "0.966" "0.994" "1.008" "1.023" "1.039" "0.623" "807.0" "722.5" "677.3" "768.1" "779.6" "802.4" "813.1" "825.4" "838.1" "502.6" "" "" "" "" "" "" "" "" "" "" "715.7" "598.5" "591.0" "574.5" "650.1" "737.1" "687.2" "682.3" "768.7" "502.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2990327377986760395" "False" "High" "IsMasterProtein" "Q8N9Q2" "Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1" "0.000" "False" "9.896" "17" "3" "5" "3" "155" "18.2" "9.85" "17.93" "3" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf13917" "285672" "ENSG00000153006" "SREK1IP1" "hsa:285672; Q32NC8; Q8N9Q2" "" "" "0" "0" "0.954" "0.876" "0.999" "0.965" "0.994" "0.986" "0.969" "0.980" "0.660" "406.8" "388.2" "356.2" "406.4" "392.7" "404.2" "401.0" "394.4" "398.8" "268.4" "" "" "" "" "" "" "" "" "" "" "360.7" "321.6" "310.8" "303.9" "327.4" "371.3" "338.9" "326.0" "365.8" "268.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2715206749087144500" "False" "High" "IsMasterProtein" "Q8WUR7" "UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2" "0.000" "False" "9.887" "13" "2" "5" "2" "153" "16.3" "9.83" "14.17" "2" "" "other cell component" "" "Pf02594" "123207" "ENSG00000169609" "C15orf40" "A6NIC9; B2R5E7; F5GX92; F8WD31; G5EA00; hsa:123207; Q8WUR7" "" "15q25 copy number variation" "1" "0" "0.991" "0.993" "1.027" "0.957" "0.991" "1.065" "0.989" "1.069" "0.466" "593.5" "588.0" "589.1" "609.6" "567.9" "588.4" "632.0" "586.9" "634.6" "276.4" "" "" "" "" "" "" "" "" "" "" "526.3" "487.1" "514.1" "455.9" "473.5" "540.5" "534.1" "485.1" "582.0" "276.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7707069974883679945" "False" "High" "IsMasterProtein" "P11836" "B-lymphocyte antigen CD20 OS=Homo sapiens OX=9606 GN=MS4A1 PE=1 SV=1" "0.000" "False" "9.886" "8" "2" "2" "2" "297" "33.1" "5.05" "6.19" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04103" "931" "ENSG00000156738" "MS4A1" "A6NMS4; B4DT24; hsa:931; P08984; P11836; Q13963" "" "Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "2" "0" "1.011" "1.199" "1.260" "1.285" "1.116" "1.051" "0.926" "1.449" "0.770" "89.2" "90.1" "106.9" "112.3" "114.5" "99.5" "93.7" "82.5" "129.1" "68.6" "" "" "" "" "" "" "" "" "" "" "79.1" "74.7" "93.3" "84.0" "95.5" "91.4" "79.2" "68.2" "118.4" "68.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1985777424174479704" "False" "High" "IsMasterProtein" "Q14669" "E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1" "0.000" "False" "9.861" "2" "3" "3" "3" "1992" "220.3" "8.48" "9.28" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00632" "9320" "ENSG00000153827" "TRIP12" "D4HL82; Q14669; Q14CA3; Q14CF1; Q15644; Q53R87; Q53TE7" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1160157628659640460" "False" "High" "IsMasterProtein" "Q5T2D2" "Trem-like transcript 2 protein OS=Homo sapiens OX=9606 GN=TREML2 PE=1 SV=2" "0.000" "False" "9.857" "3" "1" "2" "1" "321" "35.1" "9.63" "8.16" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "" "79865" "ENSG00000112195" "TREML2" "hsa:79865; Q08AP8; Q08AP9; Q5T2D2; Q8IWY0; Q9H8E9" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "0.954" "0.988" "0.965" "1.009" "1.068" "0.772" "0.882" "0.967" "0.489" "154.0" "146.9" "152.1" "148.6" "155.4" "164.5" "118.9" "135.8" "148.9" "75.3" "" "" "" "" "" "" "" "" "" "" "136.6" "121.7" "132.7" "111.2" "129.6" "151.1" "100.5" "112.2" "136.5" "75.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5511043592146931857" "False" "High" "IsMasterProtein" "Q9BSB4" "Autophagy-related protein 101 OS=Homo sapiens OX=9606 GN=ATG101 PE=1 SV=1" "0.000" "False" "9.857" "15" "3" "3" "3" "218" "25.0" "6.15" "8.98" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf07855" "60673" "ENSG00000123395" "ATG101" "hsa:60673; Q9BSB4; Q9HAE2; Q9HBN1" "Macroautophagy" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "8" "0" "1.218" "1.060" "1.392" "1.308" "1.003" "1.217" "0.991" "0.918" "1.253" "98.5" "120.0" "104.5" "137.1" "128.9" "98.8" "119.9" "97.6" "90.4" "123.4" "" "" "" "" "" "" "" "" "" "" "87.3" "99.4" "91.1" "102.6" "107.4" "90.8" "101.3" "80.7" "82.9" "123.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3678214923131327318" "False" "High" "IsMasterProtein" "Q96RQ3" "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3" "0.000" "False" "9.844" "2" "1" "1" "1" "725" "80.4" "7.78" "4.53" "1" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786" "56922" "ENSG00000078070" "MCCC1" "hsa:56922; Q59ES4; Q96RQ3; Q9H959; Q9NS97" "Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "Amino acid metabolism" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4012099030302879857" "False" "High" "IsMasterProtein" "P49137" "MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1" "0.000" "False" "9.817" "8" "4" "4" "3" "400" "45.5" "8.68" "13.02" "4" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9261" "ENSG00000162889" "MAPKAPK2" "hsa:9261; P49137; Q5SY30; Q5SY41; Q8IYD6" "Oxidative Stress Induced Senescence; Regulation of TNFR1 signaling; activated TAK1 mediates p38 MAPK activation; VEGFA-VEGFR2 Pathway; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Pleural mesothelioma; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "21" "0" "0.951" "0.926" "1.046" "1.063" "1.035" "1.034" "0.939" "0.906" "1.079" "422.8" "402.0" "391.4" "442.4" "449.4" "437.6" "437.2" "397.1" "382.9" "456.1" "" "" "" "" "" "" "" "" "" "" "374.9" "333.0" "341.5" "330.9" "374.7" "402.0" "369.5" "328.2" "351.2" "456.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3841644939449259778" "False" "High" "IsMasterProtein" "Q4LDG9" "Dynein axonemal light chain 1 OS=Homo sapiens OX=9606 GN=DNAL1 PE=1 SV=1" "0.000" "False" "9.817" "17" "3" "5" "3" "190" "21.5" "6.10" "12.99" "3" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf12799" "83544" "ENSG00000119661" "DNAL1" "B2RD38; hsa:83544; Q4LDG9; Q5JPB7; Q9BS43" "" "Ciliopathies" "1" "0" "1.090" "0.990" "1.083" "1.141" "0.949" "1.065" "1.035" "0.969" "0.856" "80.0" "87.2" "79.2" "86.6" "91.3" "75.9" "85.2" "82.8" "77.5" "68.4" "" "" "" "" "" "" "" "" "" "" "70.9" "72.2" "69.1" "64.8" "76.1" "69.7" "72.0" "68.4" "71.0" "68.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1765905761415043140" "False" "High" "IsMasterProtein" "Q96PY6" "Serine/threonine-protein kinase Nek1 OS=Homo sapiens OX=9606 GN=NEK1 PE=1 SV=2" "0.000" "False" "9.782" "1" "1" "2" "1" "1258" "142.7" "5.94" "4.32" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "4750" "ENSG00000137601" "NEK1" "G5E9Z3; hsa:4750; Q05DG5; Q14CB7; Q5H9T1; Q6PIB8; Q96PY6; Q96SS2; Q9H6P7; Q9Y594" "" "Ciliopathies; Bardet-Biedl syndrome" "2" "0" "0.451" "0.486" "0.764" "0.470" "0.389" "0.552" "0.206" "0.472" "3.862" "13.9" "6.2" "6.7" "10.6" "6.5" "5.4" "7.7" "2.9" "6.5" "53.5" "" "" "" "" "" "" "" "" "" "" "12.3" "5.2" "5.9" "7.9" "5.4" "5.0" "6.5" "2.4" "6.0" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "High" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.000" "False" "9.765" "5" "3" "3" "3" "570" "61.8" "6.11" "8.22" "3" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "1.181" "1.126" "1.422" "1.187" "1.212" "1.071" "1.257" "1.087" "1.060" "163.0" "192.5" "183.5" "231.7" "193.5" "197.5" "174.5" "204.9" "177.1" "172.8" "" "" "" "" "" "" "" "" "" "" "144.5" "159.5" "160.1" "173.3" "161.4" "181.4" "147.5" "169.3" "162.4" "172.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "846923677132301137" "False" "High" "IsMasterProtein" "Q9UBS8" "E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1" "0.000" "False" "9.756" "7" "3" "4" "3" "474" "53.8" "4.75" "10.81" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01485, Pf05773" "9604" "ENSG00000013561" "RNF14" "A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4; hsa:9604; O94793; Q6IBV0; Q9UBS8" "Antigen processing: Ubiquitination & Proteasome degradation" "Androgen receptor signaling pathway" "2" "0" "0.789" "0.791" "0.792" "0.874" "0.815" "0.735" "0.652" "0.713" "4.079" "123.8" "97.7" "98.0" "98.1" "108.2" "101.0" "91.1" "80.8" "88.3" "505.1" "" "" "" "" "" "" "" "" "" "" "109.8" "81.0" "85.5" "73.4" "90.2" "92.7" "77.0" "66.8" "81.0" "505.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966374980505742475" "False" "High" "IsMasterProtein" "Q15047" "Histone-lysine N-methyltransferase SETDB1 OS=Homo sapiens OX=9606 GN=SETDB1 PE=1 SV=1" "0.000" "False" "9.738" "2" "3" "3" "3" "1291" "143.1" "6.02" "6.57" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01429, Pf05033, Pf18300, Pf18358, Pf18359" "9869" "ENSG00000143379" "SETDB1" "A6NEW2; hsa:9869; Q15047; Q5SZD8; Q5SZD9; Q5SZE0; Q5SZE7; Q96GM9" "PKMTs methylate histone lysines" "Histone modifications; Pleural mesothelioma" "3" "0" "1.143" "1.038" "1.316" "1.097" "0.924" "1.196" "0.958" "1.029" "1.505" "122.9" "140.5" "127.6" "161.8" "134.8" "113.6" "147.0" "117.8" "126.4" "185.0" "" "" "" "" "" "" "" "" "" "" "109.0" "116.4" "111.4" "121.0" "112.4" "104.3" "124.3" "97.4" "116.0" "185.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.000" "False" "9.729" "4" "3" "3" "3" "602" "68.2" "6.43" "9.37" "3" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "1.276" "0.901" "1.217" "1.278" "0.995" "1.144" "0.476" "0.895" "12.724" "98.3" "125.4" "88.6" "119.6" "125.6" "97.8" "112.4" "46.8" "87.9" "1250.5" "" "" "" "" "" "" "" "" "" "" "87.1" "103.9" "77.3" "89.5" "104.7" "89.8" "95.0" "38.7" "80.7" "1250.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2520392851407789687" "False" "High" "IsMasterProtein" "O00401" "Actin nucleation-promoting factor WASL OS=Homo sapiens OX=9606 GN=WASL PE=1 SV=2" "0.000" "False" "9.729" "6" "3" "3" "3" "505" "54.8" "7.93" "9.90" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf00568, Pf00786, Pf02205" "8976" "ENSG00000106299" "WASL" "A1JUI9; hsa:8976; O00401; Q7Z746" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; Clathrin-mediated endocytosis; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling" "Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway" "17" "0" "1.067" "0.976" "1.041" "0.939" "0.971" "1.027" "1.035" "0.929" "0.643" "133.8" "142.8" "130.7" "139.4" "125.7" "130.0" "137.4" "138.5" "124.3" "86.0" "" "" "" "" "" "" "" "" "" "" "118.7" "118.3" "114.0" "104.2" "104.8" "119.4" "116.1" "114.5" "114.0" "86.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1343964700997120443" "False" "High" "IsMasterProtein" "O94830" "Phospholipase DDHD2 OS=Homo sapiens OX=9606 GN=DDHD2 PE=1 SV=2" "0.000" "False" "9.707" "3" "2" "2" "2" "711" "81.0" "5.39" "6.83" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "23259" "ENSG00000085788" "DDHD2" "B3KWV2; B3KXB5; hsa:23259; O94830; Q9H8X7" "Synthesis of PA" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711038865420362592" "False" "High" "IsMasterProtein" "Q9BRV8" "Suppressor of IKBKE 1 OS=Homo sapiens OX=9606 GN=SIKE1 PE=1 SV=1" "0.000" "False" "9.686" "6" "1" "1" "1" "207" "23.7" "5.21" "4.73" "1" "" "cytosol" "other molecular function" "Pf05769" "80143" "ENSG00000052723" "SIKE1" "hsa:80143; Q5TEZ7; Q5TEZ9; Q68DZ4; Q9BRV8; Q9H778" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation" "Novel intracellular components of RIG-I-like receptor pathway" "5" "0" "1.250" "0.980" "0.984" "1.176" "1.094" "1.136" "0.976" "0.989" "1.017" "113.2" "141.6" "111.0" "111.5" "133.2" "123.9" "128.7" "110.5" "112.0" "115.2" "" "" "" "" "" "" "" "" "" "" "100.4" "117.3" "96.9" "83.4" "111.1" "113.8" "108.8" "91.4" "102.8" "115.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3754382258737944185" "False" "High" "IsMasterProtein" "Q9Y546" "Leucine-rich repeat-containing protein 42 OS=Homo sapiens OX=9606 GN=LRRC42 PE=1 SV=1" "0.000" "False" "9.663" "8" "4" "5" "4" "428" "48.5" "7.46" "15.20" "4" "" "" "" "Pf13516" "115353" "ENSG00000116212" "LRRC42" "D3DQ46; hsa:115353; Q8N2Q8; Q9Y546" "" "" "0" "0" "1.208" "0.907" "1.035" "0.925" "0.883" "0.986" "0.816" "0.925" "3.208" "114.2" "137.9" "103.6" "118.2" "105.5" "100.8" "112.6" "93.2" "105.6" "366.3" "" "" "" "" "" "" "" "" "" "" "101.2" "114.2" "90.4" "88.4" "88.0" "92.6" "95.1" "77.0" "96.8" "366.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2555590194794136668" "False" "High" "IsMasterProtein" "Q9C073" "Protein FAM117A OS=Homo sapiens OX=9606 GN=FAM117A PE=1 SV=1" "0.000" "False" "9.660" "7" "3" "3" "3" "453" "48.3" "8.31" "10.48" "3" "" "" "" "Pf15388" "81558" "ENSG00000121104" "FAM117A" "B7Z7Q3; hsa:81558; Q9C073" "" "" "0" "0" "1.011" "1.062" "0.893" "0.934" "0.933" "0.874" "0.779" "0.904" "0.640" "202.5" "204.8" "215.0" "180.9" "189.2" "189.0" "177.1" "157.8" "183.0" "129.6" "" "" "" "" "" "" "" "" "" "" "179.6" "169.7" "187.6" "135.3" "157.7" "173.6" "149.6" "130.4" "167.8" "129.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9065508386869284325" "False" "High" "IsMasterProtein" "Q9Y2L5" "Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2" "0.000" "False" "9.656" "2" "3" "3" "3" "1435" "160.9" "6.87" "6.67" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf12739" "22878" "ENSG00000153339" "TRAPPC8" "A0JP15; B3KME5; hsa:22878; Q9H0L2; Q9Y2L5" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.959" "1.001" "0.893" "0.824" "0.820" "0.950" "0.881" "0.777" "1.229" "259.2" "248.6" "259.5" "231.5" "213.5" "212.5" "246.2" "228.5" "201.3" "318.6" "" "" "" "" "" "" "" "" "" "" "229.9" "205.9" "226.4" "173.2" "178.1" "195.2" "208.1" "188.9" "184.6" "318.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174147483962909046" "False" "High" "IsMasterProtein" "Q9NRX1" "RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1" "0.000" "False" "9.648" "6" "1" "1" "1" "252" "27.9" "9.73" "4.94" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "" "56902" "ENSG00000115946" "PNO1" "A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.405" "1.244" "1.496" "1.214" "1.050" "1.130" "1.113" "1.160" "5.301" "36.4" "51.2" "45.3" "54.5" "44.2" "38.2" "41.1" "40.5" "42.3" "193.1" "" "" "" "" "" "" "" "" "" "" "32.3" "42.4" "39.5" "40.8" "36.9" "35.1" "34.8" "33.5" "38.8" "193.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.000" "False" "9.648" "11" "3" "4" "3" "247" "27.9" "7.74" "13.23" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359859415185382416" "False" "High" "IsMasterProtein" "O75575" "DNA-directed RNA polymerase III subunit RPC9 OS=Homo sapiens OX=9606 GN=CRCP PE=1 SV=1" "0.000" "False" "9.648" "20" "3" "3" "3" "148" "16.9" "5.39" "8.81" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03874" "27297" "ENSG00000241258" "CRCP" "A8MUZ4; A8MW23; B2R4H4; B4E198; hsa:27297; O75575; Q3KRA3; Q5HYF1; Q8IXL4" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Myometrial relaxation and contraction pathways" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2714987798271116551" "False" "High" "IsMasterProtein" "Q9BUE0" "Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1" "0.000" "False" "9.646" "13" "3" "5" "3" "208" "23.6" "6.54" "15.69" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09637" "54797" "ENSG00000130772; ENSG00000284944" "MED18" "D3DPM1; hsa:54797; Q9BUE0; Q9NXU9" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "" "3" "0" "0.919" "1.066" "1.021" "1.057" "1.031" "1.065" "1.058" "0.994" "1.047" "348.7" "320.5" "371.7" "356.1" "368.4" "359.6" "371.2" "368.9" "346.6" "365.2" "" "" "" "" "" "" "" "" "" "" "309.2" "265.5" "324.3" "266.3" "307.2" "330.3" "313.7" "304.9" "317.9" "365.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314787517679089989" "False" "High" "IsMasterProtein" "Q8WUX9" "Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1" "0.000" "False" "9.630" "7" "3" "3" "3" "453" "50.9" "5.35" "7.81" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "91782" "ENSG00000147457" "CHMP7" "B2RDT3; B4DKJ6; D3DSS1; hsa:91782; Q8NDM1; Q8WUX9; Q9BT50" "Late endosomal microautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "1.089" "0.808" "1.254" "0.925" "0.961" "1.054" "0.604" "0.912" "7.735" "76.7" "83.5" "61.9" "96.2" "71.0" "73.7" "80.9" "46.4" "69.9" "593.2" "" "" "" "" "" "" "" "" "" "" "68.0" "69.2" "54.0" "71.9" "59.2" "67.7" "68.3" "38.3" "64.1" "593.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892747589052197154" "False" "High" "IsMasterProtein" "Q5W0B1" "ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1" "0.000" "False" "9.601" "2" "2" "2" "2" "726" "81.1" "5.72" "6.91" "2" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13923" "79596" "ENSG00000152193" "OBI1" "B2RN99; hsa:79596; Q5W0B1; Q8TBY2; Q9H0T2; Q9H8M0" "" "" "0" "0" "1.321" "1.149" "0.962" "0.982" "1.083" "1.059" "0.787" "0.947" "3.382" "131.9" "174.3" "151.6" "127.0" "129.6" "142.8" "139.7" "103.9" "124.9" "446.2" "" "" "" "" "" "" "" "" "" "" "117.0" "144.4" "132.3" "94.9" "108.1" "131.2" "118.1" "85.9" "114.5" "446.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4562553461680680521" "False" "High" "IsMasterProtein" "Q9Y2Q5" "Ragulator complex protein LAMTOR2 OS=Homo sapiens OX=9606 GN=LAMTOR2 PE=1 SV=1" "0.000" "False" "9.598" "15" "2" "3" "2" "125" "13.5" "5.40" "9.48" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf03259" "28956" "ENSG00000116586" "LAMTOR2" "hsa:28956; Q5VY97; Q5VY98; Q5VY99; Q9Y2Q5" "Neutrophil degranulation; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; MAP2K and MAPK activation" "" "9" "0" "1.060" "1.000" "1.112" "1.166" "1.079" "1.182" "1.207" "1.051" "0.696" "382.0" "404.9" "381.8" "424.7" "445.5" "412.0" "451.5" "461.0" "401.6" "265.8" "" "" "" "" "" "" "" "" "" "" "338.7" "335.4" "333.1" "317.6" "371.5" "378.5" "381.6" "381.0" "368.3" "265.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2947777995853760023" "False" "High" "IsMasterProtein" "Q53GQ0" "Very-long-chain 3-oxoacyl-CoA reductase OS=Homo sapiens OX=9606 GN=HSD17B12 PE=1 SV=2" "0.000" "False" "9.594" "12" "4" "4" "4" "312" "34.3" "9.32" "8.70" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf00106" "51144" "ENSG00000149084" "HSD17B12" "A8K9B0; D3DR23; hsa:51144; Q53GQ0; Q96EA9; Q96JU2; Q9Y6G8" "Synthesis of very long-chain fatty acyl-CoAs; Androgen biosynthesis" "Mitochondrial fatty acid synthesis pathway" "3" "0" "1.010" "0.578" "1.020" "1.120" "0.918" "0.962" "1.411" "1.115" "0.630" "21.6" "21.8" "12.5" "22.0" "24.2" "19.8" "20.8" "30.5" "24.1" "13.6" "" "" "" "" "" "" "" "" "" "" "19.2" "18.1" "10.9" "16.5" "20.2" "18.2" "17.6" "25.2" "22.1" "13.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659599348828785252" "False" "High" "IsMasterProtein" "Q96DB9" "FXYD domain-containing ion transport regulator 5 OS=Homo sapiens OX=9606 GN=FXYD5 PE=1 SV=2" "0.000" "False" "9.567" "11" "1" "1" "1" "178" "19.5" "5.85" "7.07" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes" "cytoskeletal activity;other molecular function" "Pf02038" "53827" "ENSG00000089327" "FXYD5" "B7WNZ8; hsa:53827; Q6UW44; Q96DB9; Q9HC34; Q9P039" "" "" "0" "0" "1.031" "0.844" "1.249" "1.001" "0.953" "0.833" "0.834" "0.763" "0.586" "73.5" "75.8" "62.0" "91.8" "73.5" "70.0" "61.2" "61.3" "56.1" "43.1" "" "" "" "" "" "" "" "" "" "" "65.2" "62.8" "54.1" "68.7" "61.3" "64.3" "51.8" "50.7" "51.4" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "High" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.000" "False" "9.528" "5" "3" "3" "3" "477" "54.2" "6.15" "5.99" "3" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "0.922" "0.868" "0.889" "0.842" "0.999" "0.884" "0.858" "0.931" "0.604" "361.7" "333.5" "313.9" "321.6" "304.4" "361.4" "319.8" "310.3" "336.7" "218.4" "" "" "" "" "" "" "" "" "" "" "320.7" "276.2" "273.9" "240.5" "253.8" "332.0" "270.3" "256.5" "308.8" "218.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3092870897652950663" "False" "High" "IsMasterProtein" "O14841" "5-oxoprolinase OS=Homo sapiens OX=9606 GN=OPLAH PE=1 SV=3" "0.000" "False" "9.520" "2" "3" "3" "3" "1288" "137.4" "6.58" "9.50" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf01968, Pf02538, Pf05378, Pf19278" "26873" "ENSG00000178814" "OPLAH" "A5PKY8; hsa:26873; O14841; Q75W65; Q9Y4Q0" "Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD" "Glutathione metabolism" "3" "0" "0.975" "0.974" "1.146" "1.027" "1.047" "1.048" "1.077" "0.961" "0.669" "430.5" "419.7" "419.3" "493.2" "442.2" "450.8" "451.1" "463.8" "413.5" "288.1" "" "" "" "" "" "" "" "" "" "" "381.8" "347.6" "365.8" "368.9" "368.8" "414.1" "381.2" "383.4" "379.3" "288.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1227162241055397784" "False" "High" "IsMasterProtein" "Q9H0W8" "Nonsense-mediated mRNA decay factor SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1" "0.000" "False" "9.520" "6" "2" "2" "2" "520" "57.6" "7.01" "8.21" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "" "56006" "ENSG00000105771" "SMG9" "hsa:56006; O60429; Q9H0W8; Q9H9A9" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "0.911" "0.989" "1.053" "0.903" "0.923" "0.867" "0.721" "0.934" "2.659" "135.2" "123.2" "133.7" "142.4" "122.0" "124.7" "117.2" "97.4" "126.2" "359.4" "" "" "" "" "" "" "" "" "" "" "119.9" "102.0" "116.7" "106.5" "101.7" "114.5" "99.0" "80.5" "115.8" "359.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220085271204376127" "False" "High" "IsMasterProtein" "O95983" "Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1" "0.000" "False" "9.515" "12" "4" "4" "3" "291" "32.8" "5.34" "9.51" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "53615" "ENSG00000071655" "MBD3" "A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in progeria" "7" "0" "0.951" "0.930" "0.863" "0.949" "0.991" "0.919" "0.776" "0.996" "2.942" "316.4" "300.8" "294.2" "273.1" "300.4" "313.4" "290.8" "245.6" "315.0" "931.0" "" "" "" "" "" "" "" "" "" "" "280.6" "249.1" "256.7" "204.3" "250.5" "287.9" "245.7" "203.0" "288.9" "931.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7680065627734331684" "False" "High" "IsMasterProtein" "Q3KRA6" "UPF0538 protein C2orf76 OS=Homo sapiens OX=9606 GN=C2orf76 PE=1 SV=3" "0.000" "False" "9.501" "16" "2" "2" "2" "126" "14.6" "6.93" "5.50" "2" "" "" "" "Pf10209" "130355" "ENSG00000186132" "C2orf76" "B7ZLS8; hsa:130355; Q3KRA6; Q4VC35" "" "" "0" "0" "1.192" "0.947" "1.166" "1.092" "0.934" "1.094" "1.052" "0.918" "1.104" "203.5" "242.5" "192.7" "237.2" "222.2" "190.1" "222.5" "214.0" "186.8" "224.5" "" "" "" "" "" "" "" "" "" "" "180.4" "200.9" "168.1" "177.4" "185.3" "174.6" "188.1" "176.9" "171.4" "224.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3776455647046576995" "False" "High" "IsMasterProtein" "Q7L3B6" "Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1" "0.000" "False" "9.471" "9" "4" "4" "4" "337" "38.8" "5.34" "11.75" "4" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf08565" "55664" "ENSG00000106993" "CDC37L1" "B1AL70; hsa:55664; Q7L3B6; Q9NWS3; Q9NX16" "Platelet degranulation" "" "1" "0" "0.985" "0.969" "0.961" "0.900" "0.909" "0.926" "0.856" "0.883" "1.572" "530.2" "522.1" "513.7" "509.6" "477.3" "481.7" "491.0" "454.0" "468.2" "833.5" "" "" "" "" "" "" "" "" "" "" "470.1" "432.5" "448.3" "381.1" "398.0" "442.5" "415.0" "375.3" "429.4" "833.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9179155935409940173" "False" "High" "IsMasterProtein" "Q15750" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens OX=9606 GN=TAB1 PE=1 SV=1" "0.000" "False" "9.466" "4" "2" "2" "2" "504" "54.6" "5.52" "6.12" "2" "developmental processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "10454" "ENSG00000100324" "TAB1" "hsa:10454; Q15750; Q2PP09; Q8IZW2" "NOD1/2 Signaling Pathway; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; TGF-beta signaling pathway; MAPK signaling pathway; TLR4 signaling and tolerance; miRNA role in immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; Toll-like receptor signaling pathway" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8434539253909675931" "False" "High" "IsMasterProtein" "Q13588" "GRB2-related adapter protein OS=Homo sapiens OX=9606 GN=GRAP PE=1 SV=1" "0.000" "False" "9.437" "9" "2" "2" "2" "217" "25.3" "7.03" "6.77" "2" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018" "10750" "ENSG00000154016" "GRAP" "hsa:10750; Q13588" "Signaling by SCF-KIT" "" "1" "0" "1.120" "0.914" "1.024" "0.868" "0.976" "0.828" "0.644" "0.844" "6.923" "68.5" "76.7" "62.6" "70.2" "59.5" "66.9" "56.8" "44.1" "57.9" "474.4" "" "" "" "" "" "" "" "" "" "" "60.8" "63.6" "54.7" "52.5" "49.6" "61.4" "48.0" "36.5" "53.1" "474.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1389983804562693885" "False" "High" "IsMasterProtein" "A2RUC4" "tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1" "0.000" "False" "9.407" "9" "3" "3" "3" "315" "36.5" "7.55" "8.68" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13621" "129450" "ENSG00000162971" "TYW5" "A2RUC4; B2RNE3; hsa:129450; Q8N1R2" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "0.970" "0.860" "0.877" "0.769" "0.789" "0.848" "0.933" "1.059" "0.604" "203.9" "197.8" "175.2" "178.8" "156.8" "160.9" "172.8" "190.2" "215.9" "123.2" "" "" "" "" "" "" "" "" "" "" "180.8" "163.9" "152.9" "133.8" "130.7" "147.8" "146.1" "157.2" "198.0" "123.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4179257016855703776" "False" "High" "IsMasterProtein" "Q53QV2" "Protein LBH OS=Homo sapiens OX=9606 GN=LBH PE=1 SV=1" "0.000" "False" "9.404" "15" "1" "3" "1" "105" "12.2" "4.41" "8.91" "1" "other biological processes" "nucleus;other cell component" "" "Pf15317" "81606" "ENSG00000213626" "LBH" "B2RBC2; hsa:81606; Q53QV2; Q9H0Q1" "" "" "0" "0" "0.896" "0.952" "0.815" "0.665" "0.844" "0.923" "0.970" "1.000" "0.498" "24.8" "22.2" "23.6" "20.2" "16.5" "21.0" "22.9" "24.1" "24.8" "12.4" "" "" "" "" "" "" "" "" "" "" "22.0" "18.4" "20.6" "15.1" "13.8" "19.2" "19.4" "19.9" "22.8" "12.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4042052557542696256" "False" "High" "IsMasterProtein" "Q8TAP8" "Protein phosphatase 1 regulatory subunit 35 OS=Homo sapiens OX=9606 GN=PPP1R35 PE=1 SV=1" "0.000" "False" "9.363" "9" "1" "1" "1" "253" "27.9" "8.68" "6.68" "1" "developmental processes;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf15503" "221908" "ENSG00000160813" "PPP1R35" "A4D2C5; hsa:221908; Q8TAP8" "" "" "0" "0" "0.931" "0.950" "0.960" "0.903" "0.876" "0.948" "0.937" "0.835" "1.159" "88.4" "82.2" "84.0" "84.9" "79.8" "77.4" "83.7" "82.8" "73.8" "102.4" "" "" "" "" "" "" "" "" "" "" "78.4" "68.1" "73.3" "63.5" "66.5" "71.1" "70.8" "68.4" "67.7" "102.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4909217675583698117" "False" "High" "IsMasterProtein" "A0A3B3IS91" "POLG alternative reading frame OS=Homo sapiens OX=9606 GN=POLGARF PE=1 SV=2" "0.000" "False" "9.353" "17" "2" "2" "2" "260" "25.5" "12.04" "7.92" "2" "" "non-structural extracellular;nucleus" "" "" "" "ENSG00000291307" "POLGARF" "A0A3B3IS91" "" "" "0" "0" "1.046" "1.000" "1.047" "1.017" "0.940" "0.992" "0.966" "0.897" "0.667" "243.9" "255.1" "244.0" "255.4" "248.0" "229.3" "241.9" "235.6" "218.9" "162.7" "" "" "" "" "" "" "" "" "" "" "216.3" "211.3" "212.9" "191.0" "206.8" "210.6" "204.5" "194.7" "200.7" "162.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3640417393520932039" "False" "High" "IsMasterProtein" "Q9P031" "Thyroid transcription factor 1-associated protein 26 OS=Homo sapiens OX=9606 GN=CCDC59 PE=1 SV=2" "0.000" "False" "9.342" "9" "2" "2" "2" "241" "28.7" "9.88" "6.93" "2" "" "nucleus" "" "Pf08524" "29080" "ENSG00000133773" "CCDC59" "hsa:29080; Q9H2V5; Q9NW62; Q9P031" "Surfactant metabolism" "" "1" "0" "1.047" "0.945" "1.032" "1.019" "0.964" "0.706" "0.678" "0.730" "0.710" "398.5" "417.4" "376.8" "411.2" "406.1" "384.0" "281.3" "270.3" "291.1" "282.8" "" "" "" "" "" "" "" "" "" "" "353.4" "345.8" "328.8" "307.5" "338.7" "352.7" "237.7" "223.4" "266.9" "282.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2332005078854859868" "False" "High" "IsMasterProtein" "Q9BWT6" "Meiotic nuclear division protein 1 homolog OS=Homo sapiens OX=9606 GN=MND1 PE=1 SV=1" "0.000" "False" "9.335" "11" "2" "2" "2" "205" "23.7" "8.19" "7.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism" "nucleus" "nucleic acid binding activity" "Pf03962, Pf18517" "84057" "ENSG00000121211" "MND1" "B2R5F9; hsa:84057; Q9BWT6" "Meiotic recombination" "Primary ovarian insufficiency" "2" "0" "1.005" "0.945" "1.026" "1.068" "1.117" "1.126" "1.024" "1.051" "1.745" "277.6" "279.0" "262.4" "284.9" "296.4" "310.0" "312.5" "284.3" "291.8" "484.4" "" "" "" "" "" "" "" "" "" "" "246.1" "231.1" "228.9" "213.1" "247.2" "284.8" "264.1" "235.0" "267.7" "484.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1756983135160374971" "False" "High" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "0.000" "False" "9.327" "5" "3" "3" "3" "622" "71.6" "7.31" "10.47" "3" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "1.034" "0.873" "1.189" "1.051" "0.888" "1.236" "1.059" "1.027" "2.439" "362.0" "374.3" "315.9" "430.4" "380.4" "321.5" "447.3" "383.2" "371.8" "882.9" "" "" "" "" "" "" "" "" "" "" "321.0" "310.1" "275.7" "321.9" "317.2" "295.3" "378.1" "316.8" "341.0" "882.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330394968015135701" "False" "High" "IsMasterProtein" "Q9P2R3" "Rabankyrin-5 OS=Homo sapiens OX=9606 GN=ANKFY1 PE=1 SV=2" "0.000" "False" "9.319" "2" "2" "2" "2" "1169" "128.3" "6.10" "5.94" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00023, Pf00651, Pf01363, Pf12796" "51479" "ENSG00000185722" "ANKFY1" "A8KA65; hsa:51479; Q5RKV4; Q9P2R3; Q9ULG5" "RHOD GTPase cycle" "" "1" "0" "0.935" "0.924" "1.289" "0.934" "0.870" "1.012" "0.557" "0.701" "7.769" "130.2" "121.7" "120.4" "167.8" "121.7" "113.3" "131.8" "72.5" "91.3" "1011.6" "" "" "" "" "" "" "" "" "" "" "115.5" "100.8" "105.0" "125.5" "101.5" "104.1" "111.4" "59.9" "83.7" "1011.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3269351355245221217" "False" "High" "IsMasterProtein" "Q8NF37" "Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2" "0.000" "False" "9.314" "4" "2" "2" "2" "534" "59.1" "6.02" "6.75" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01553, Pf13833" "79888" "ENSG00000153395" "LPCAT1" "hsa:79888; Q1HAQ1; Q7Z4G6; Q8N3U7; Q8NF37; Q8WUL8; Q9GZW6" "Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379661527543753299" "False" "High" "IsMasterProtein" "Q6PID8" "Kelch domain-containing protein 10 OS=Homo sapiens OX=9606 GN=KLHDC10 PE=1 SV=1" "0.000" "False" "9.308" "5" "1" "1" "1" "442" "49.1" "9.38" "5.11" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13854" "23008" "ENSG00000128607" "KLHDC10" "hsa:23008; Q6PID8; Q86Y99; Q92554" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "-8717511238945883438" "False" "High" "IsMasterProtein" "Q12769" "Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3" "0.000" "False" "9.305" "2" "3" "3" "3" "1436" "162.0" "5.50" "8.93" "3" "other metabolic processes;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf11715" "23279" "ENSG00000030066" "NUP160" "B4DYE8; B4E2J9; hsa:23279; Q08AD3; Q12769; Q7Z5X6; Q96GB3; Q9H660" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "35" "0" "1.125" "1.028" "0.964" "1.173" "0.876" "1.127" "0.983" "1.193" "2.744" "79.4" "89.3" "81.6" "76.5" "93.1" "69.5" "89.5" "78.1" "94.7" "217.8" "" "" "" "" "" "" "" "" "" "" "70.4" "74.0" "71.2" "57.2" "77.7" "63.9" "75.6" "64.5" "86.8" "217.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6537732196203622572" "False" "High" "IsMasterProtein" "Q8N884" "Cyclic GMP-AMP synthase OS=Homo sapiens OX=9606 GN=CGAS PE=1 SV=2" "0.000" "False" "9.304" "4" "2" "2" "2" "522" "58.8" "9.48" "7.56" "2" "cell-cell signaling;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03281, Pf20266" "115004" "ENSG00000164430" "CGAS" "hsa:115004; L0L2J9; Q14CV6; Q32NC9; Q5SWL0; Q5SWL1; Q8N884; Q96E45" "STING mediated induction of host immune responses" "Cytosolic DNA-sensing pathway; STING pathway in Kawasaki-like disease and COVID-19; Lung pathology of COVID-19; 8p23.1 copy number variation syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2807670351825780389" "False" "High" "IsMasterProtein" "P0DI82" "Trafficking protein particle complex subunit 2B OS=Homo sapiens OX=9606 GN=TRAPPC2B PE=1 SV=1" "0.000" "False" "9.283" "16" "2" "2" "2" "140" "16.4" "6.52" "8.05" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04628" "6399" "ENSG00000256060" "TRAPPC2B" "A6NEG0; hsa:6399; O14582; P0DI82; Q9HD16" "" "" "0" "0" "0.903" "0.817" "1.013" "1.140" "1.012" "0.920" "0.933" "1.041" "1.599" "107.2" "96.8" "87.5" "108.6" "122.2" "108.5" "98.6" "100.0" "111.6" "171.4" "" "" "" "" "" "" "" "" "" "" "95.0" "80.2" "76.4" "81.2" "101.9" "99.7" "83.3" "82.7" "102.3" "171.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7084160994910384820" "False" "High" "IsMasterProtein" "Q96G04" "Protein-lysine N-methyltransferase EEF2KMT OS=Homo sapiens OX=9606 GN=EEF2KMT PE=1 SV=2" "0.000" "False" "9.273" "8" "2" "2" "2" "330" "36.9" "6.05" "7.26" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf10294, Pf14904" "196483" "ENSG00000118894" "EEF2KMT" "D3DUF0; Q96G04; Q96S85" "Protein methylation" "" "1" "0" "0.936" "0.844" "0.972" "0.961" "0.984" "0.905" "0.824" "0.849" "0.814" "339.2" "317.4" "286.3" "329.7" "326.1" "333.6" "306.8" "279.5" "287.9" "276.2" "" "" "" "" "" "" "" "" "" "" "300.8" "262.9" "249.8" "246.6" "271.9" "306.5" "259.3" "231.0" "264.1" "276.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.000" "False" "9.272" "21" "2" "6" "2" "77" "8.5" "8.75" "17.98" "2" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.948" "0.967" "0.936" "0.965" "1.079" "0.989" "1.021" "1.024" "0.477" "1084.0" "1027.7" "1048.4" "1014.6" "1046.5" "1169.3" "1071.6" "1106.3" "1109.6" "516.7" "" "" "" "" "" "" "" "" "" "" "961.2" "851.3" "914.8" "758.8" "872.6" "1074.1" "905.7" "914.4" "1017.6" "516.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785225310514612646" "False" "High" "IsMasterProtein" "Q9NZ45" "CDGSH iron-sulfur domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CISD1 PE=1 SV=1" "0.000" "False" "9.239" "14" "1" "1" "1" "108" "12.2" "9.09" "5.71" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf09360, Pf10660" "55847" "ENSG00000122873" "CISD1" "hsa:55847; Q1X902; Q9NZ45" "" "Adipogenesis; Ferroptosis" "2" "0" "0.994" "0.978" "1.063" "0.982" "1.032" "1.074" "1.050" "1.077" "1.216" "197.7" "196.5" "193.5" "210.1" "194.2" "204.0" "212.3" "207.6" "213.0" "240.4" "" "" "" "" "" "" "" "" "" "" "175.3" "162.8" "168.8" "157.1" "162.0" "187.4" "179.5" "171.6" "195.4" "240.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9099132526023132947" "False" "High" "IsMasterProtein" "Q9Y6D5" "Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3" "0.000" "False" "9.236" "1" "2" "3" "2" "1785" "201.9" "6.33" "11.51" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10564" "ENSG00000124198" "ARFGEF2" "hsa:10564; Q5TFT9; Q9NTS1; Q9Y6D5" "Association of TriC/CCT with target proteins during biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7425032110570727878" "False" "High" "IsMasterProtein" "Q96NT1" "Nucleosome assembly protein 1-like 5 OS=Homo sapiens OX=9606 GN=NAP1L5 PE=1 SV=1" "0.000" "False" "9.234" "7" "1" "2" "1" "182" "19.6" "4.21" "4.81" "1" "cell organization and biogenesis" "nucleus" "" "Pf00956" "266812" "ENSG00000177432" "NAP1L5" "hsa:266812; Q96NT1" "" "" "0" "0" "1.238" "0.794" "0.934" "0.778" "0.833" "0.915" "0.860" "1.127" "0.609" "492.9" "610.3" "391.3" "460.3" "383.3" "410.8" "451.1" "423.7" "555.8" "300.4" "" "" "" "" "" "" "" "" "" "" "437.1" "505.5" "341.4" "344.2" "319.6" "377.4" "381.3" "350.2" "509.7" "300.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7548254055495868617" "False" "High" "IsMasterProtein" "Q9BZD4" "Kinetochore protein Nuf2 OS=Homo sapiens OX=9606 GN=NUF2 PE=1 SV=2" "0.000" "False" "9.210" "8" "4" "4" "4" "464" "54.3" "8.27" "11.09" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03800" "83540" "ENSG00000143228" "NUF2" "hsa:83540; Q8WU69; Q96HJ4; Q96Q78; Q9BZD4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.962" "0.923" "0.948" "0.903" "1.091" "0.862" "0.010" "1.090" "19.773" "109.7" "105.6" "101.2" "104.0" "99.1" "119.7" "94.5" "0.0" "119.6" "2169.9" "" "" "" "" "" "" "" "" "" "" "97.3" "87.5" "88.3" "77.8" "82.7" "110.0" "79.9" "0.0" "109.7" "2169.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2529735565303520700" "False" "High" "IsMasterProtein" "Q9BQS8" "FYVE and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FYCO1 PE=1 SV=3" "0.000" "False" "9.201" "2" "3" "3" "3" "1478" "166.9" "4.92" "8.89" "3" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "79443" "ENSG00000163820" "FYCO1" "B7ZKT7; hsa:79443; Q3MJE6; Q86T41; Q86TB1; Q8TEF9; Q96IV5; Q9BQS8; Q9H8P9" "" "Clock-controlled autophagy in bone metabolism" "1" "0" "0.936" "0.866" "0.965" "0.878" "0.828" "0.798" "0.902" "1.027" "1.354" "604.3" "565.6" "523.1" "583.1" "530.5" "500.1" "482.5" "545.0" "620.9" "818.4" "" "" "" "" "" "" "" "" "" "" "535.9" "468.5" "456.5" "436.1" "442.3" "459.4" "407.8" "450.5" "569.4" "818.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "712228557573966988" "False" "High" "IsMasterProtein" "Q9ULC3" "Ras-related protein Rab-23 OS=Homo sapiens OX=9606 GN=RAB23 PE=1 SV=1" "0.000" "False" "9.198" "12" "3" "4" "3" "237" "26.6" "6.60" "9.55" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "51715" "ENSG00000112210" "RAB23" "B2R9I5; hsa:51715; Q68DJ6; Q8NI06; Q9P023; Q9ULC3" "RAB geranylgeranylation" "Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "4" "0" "0.959" "0.882" "0.898" "0.864" "1.015" "0.871" "0.896" "0.894" "0.498" "356.0" "341.4" "313.9" "319.7" "307.5" "361.3" "310.2" "319.0" "318.3" "177.3" "" "" "" "" "" "" "" "" "" "" "315.7" "282.8" "273.9" "239.1" "256.4" "331.9" "262.2" "263.7" "291.9" "177.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696589814023666564" "False" "High" "IsMasterProtein" "Q13503" "Mediator of RNA polymerase II transcription subunit 21 OS=Homo sapiens OX=9606 GN=MED21 PE=1 SV=1" "0.000" "False" "9.196" "17" "2" "2" "2" "144" "15.6" "4.45" "5.86" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11221" "9412" "ENSG00000152944" "MED21" "B2R4I3; hsa:9412; Q13503; Q6IB05; Q92811" "RSV-host interactions; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "" "3" "0" "1.047" "1.012" "1.074" "1.073" "0.942" "1.041" "1.051" "1.010" "1.008" "145.2" "151.9" "146.9" "155.9" "155.7" "136.7" "151.0" "152.6" "146.6" "146.3" "" "" "" "" "" "" "" "" "" "" "128.7" "125.9" "128.2" "116.6" "129.8" "125.6" "127.7" "126.1" "134.4" "146.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172063933685251467" "False" "High" "IsMasterProtein" "Q9BTA9" "WW domain-containing adapter protein with coiled-coil OS=Homo sapiens OX=9606 GN=WAC PE=1 SV=3" "0.000" "False" "9.188" "4" "3" "4" "3" "647" "70.7" "9.45" "9.92" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00397" "51322" "ENSG00000095787" "WAC" "A8K2A9; C9JBT9; D3DRW5; D3DRW6; D3DRW7; hsa:51322; Q53EN9; Q5JU75; Q5JU77; Q5VXK0; Q5VXK2; Q8TCK1; Q96DP3; Q96FW6; Q96JI3; Q9BTA9" "E3 ubiquitin ligases ubiquitinate target proteins" "" "1" "0" "0.871" "0.776" "0.654" "0.691" "0.611" "0.620" "0.590" "0.828" "2.058" "273.5" "238.2" "212.3" "178.9" "188.8" "167.0" "169.5" "161.4" "226.3" "562.8" "" "" "" "" "" "" "" "" "" "" "242.5" "197.3" "185.3" "133.8" "157.5" "153.4" "143.2" "133.4" "207.5" "562.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155133754937223753" "False" "High" "IsMasterProtein" "O43402" "ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1" "0.000" "False" "9.183" "12" "2" "2" "2" "210" "23.8" "6.40" "9.36" "2" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf03665" "10328" "ENSG00000131148" "EMC8" "C9JB21; hsa:10328; O43402" "" "" "0" "0" "1.010" "1.042" "1.195" "1.079" "0.985" "1.232" "1.539" "1.164" "2.097" "59.0" "59.5" "61.4" "70.5" "63.6" "58.1" "72.6" "90.7" "68.6" "123.6" "" "" "" "" "" "" "" "" "" "" "52.3" "49.3" "53.6" "52.7" "53.1" "53.4" "61.4" "75.0" "62.9" "123.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7903736519056340786" "False" "High" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "0.000" "False" "9.179" "5" "3" "5" "3" "500" "53.9" "8.66" "16.49" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Basigin interactions; Pyruvate metabolism; Aspirin ADME; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "8" "0" "0.948" "0.685" "0.683" "0.606" "0.423" "0.467" "0.635" "0.955" "0.530" "858.6" "813.6" "588.4" "586.3" "520.1" "363.4" "401.0" "545.1" "820.2" "455.4" "" "" "" "" "" "" "" "" "" "" "761.4" "674.0" "513.4" "438.5" "433.7" "333.8" "338.9" "450.6" "752.2" "455.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3568481181707392039" "False" "High" "IsMasterProtein" "P30307" "M-phase inducer phosphatase 3 OS=Homo sapiens OX=9606 GN=CDC25C PE=1 SV=2" "0.000" "False" "9.175" "4" "2" "2" "2" "473" "53.3" "6.79" "7.60" "2" "cell cycle OR cell proliferation;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00581, Pf06617" "995" "ENSG00000158402" "CDC25C" "D3DQB8; hsa:995; P30307; Q96PL3; Q9H168; Q9H2E8; Q9H2E9; Q9H2F1" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Activation of ATR in response to replication stress; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Polo-like kinase mediated events" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling pathway; p53 transcriptional gene network; CCL18 signaling pathway; DNA damage response; Monoamine transport" "15" "0" "1.147" "1.199" "1.147" "1.273" "1.076" "1.108" "1.043" "0.971" "2.002" "89.4" "102.6" "107.2" "102.5" "113.8" "96.2" "99.1" "93.2" "86.8" "179.0" "" "" "" "" "" "" "" "" "" "" "79.3" "85.0" "93.5" "76.7" "94.9" "88.3" "83.7" "77.1" "79.6" "179.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2874165042467263127" "False" "High" "IsMasterProtein" "Q6PJG6" "BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2" "0.000" "False" "9.137" "4" "3" "3" "3" "821" "88.1" "5.27" "8.39" "3" "cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf02985" "221927" "ENSG00000106009" "BRAT1" "A4D200; C9JY24; hsa:221927; Q6PJG6; Q8IW85; Q8IZ43; Q8WVR8; Q96IV9; Q9H7J8; Q9UFA3" "" "" "0" "0" "0.928" "0.674" "1.256" "0.801" "0.768" "0.819" "0.825" "0.917" "3.576" "34.9" "32.4" "23.5" "43.8" "28.0" "26.8" "28.6" "28.8" "32.0" "124.7" "" "" "" "" "" "" "" "" "" "" "30.9" "26.8" "20.5" "32.8" "23.3" "24.6" "24.1" "23.8" "29.3" "124.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "9.131" "13" "2" "2" "2" "178" "20.4" "5.03" "7.42" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "" "Metapathway biotransformation Phase I and II" "1" "0" "0.878" "0.956" "0.936" "0.955" "0.920" "1.009" "1.006" "0.890" "0.719" "176.5" "155.0" "168.7" "165.3" "168.6" "162.4" "178.2" "177.6" "157.0" "126.9" "" "" "" "" "" "" "" "" "" "" "156.5" "128.4" "147.2" "123.6" "140.6" "149.2" "150.6" "146.8" "144.0" "126.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-101820050033511890" "False" "High" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0.000" "False" "9.129" "3" "4" "4" "4" "1978" "220.5" "6.38" "7.22" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "Transcriptional regulation of white adipocyte differentiation" "" "1" "0" "0.834" "0.860" "0.981" "0.854" "0.983" "0.968" "0.771" "0.888" "2.479" "113.6" "94.7" "97.7" "111.5" "97.0" "111.7" "109.9" "87.6" "100.8" "281.6" "" "" "" "" "" "" "" "" "" "" "100.7" "78.5" "85.3" "83.4" "80.9" "102.6" "92.9" "72.4" "92.5" "281.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3461094019956647414" "False" "High" "IsMasterProtein" "Q96KQ7" "Histone-lysine N-methyltransferase EHMT2 OS=Homo sapiens OX=9606 GN=EHMT2 PE=1 SV=3" "0.000" "False" "9.127" "2" "3" "3" "3" "1210" "132.3" "5.45" "9.75" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00856, Pf05033, Pf21533" "10919" "ENSG00000204371; ENSG00000206376; ENSG00000227333; ENSG00000232045; ENSG00000236759; ENSG00000238134" "EHMT2" "B0UZY2; hsa:10919; Q14349; Q5JP83; Q5JQ92; Q5JQA1; Q5JQG3; Q6PK06; Q96KQ7; Q96MH5; Q96QD0; Q9UQL8; Q9Y331" "Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Transcriptional Regulation by VENTX; Regulation of TP53 Activity through Methylation; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Histone modifications; Ethanol effects on histone modifications; MTHFR deficiency" "10" "0" "0.897" "0.746" "0.828" "0.824" "0.763" "0.674" "0.721" "0.955" "2.281" "76.3" "68.4" "56.9" "63.2" "62.9" "58.2" "51.4" "55.0" "72.9" "174.0" "" "" "" "" "" "" "" "" "" "" "67.6" "56.7" "49.6" "47.2" "52.4" "53.5" "43.4" "45.5" "66.8" "174.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370565265455321105" "False" "High" "IsMasterProtein" "Q8IU81" "Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1" "0.000" "False" "9.117" "5" "2" "3" "2" "584" "61.6" "8.18" "11.93" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "26145" "ENSG00000170604" "IRF2BP1" "Q53EL7; Q6DC95; Q8IU81; Q9BRZ9; Q9Y4P4" "" "" "0" "0" "1.072" "0.979" "1.089" "0.992" "0.833" "1.217" "0.669" "1.096" "7.567" "40.2" "43.1" "39.4" "43.8" "39.9" "33.5" "48.9" "26.9" "44.1" "304.3" "" "" "" "" "" "" "" "" "" "" "35.7" "35.7" "34.4" "32.7" "33.3" "30.8" "41.4" "22.2" "40.4" "304.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4890653308716064100" "False" "High" "IsMasterProtein" "Q9H981" "Actin-related protein 8 OS=Homo sapiens OX=9606 GN=ACTR8 PE=1 SV=2" "0.000" "False" "9.093" "3" "2" "2" "2" "624" "70.4" "7.78" "6.99" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf00022" "93973" "ENSG00000113812" "ACTR8" "B3KSW7; hsa:93973; Q8N566; Q9H663; Q9H981" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "1.033" "0.905" "0.966" "0.950" "0.924" "0.952" "0.526" "0.933" "10.573" "186.5" "192.6" "168.7" "180.2" "177.2" "172.4" "177.5" "98.1" "174.1" "1971.8" "" "" "" "" "" "" "" "" "" "" "165.4" "159.6" "147.2" "134.8" "147.8" "158.3" "150.0" "81.1" "159.7" "1971.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.000" "False" "9.054" "10" "3" "3" "3" "338" "37.4" "6.98" "8.50" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "7" "0" "1.010" "0.972" "0.993" "0.989" "0.972" "1.375" "1.343" "1.344" "2.348" "369.5" "373.3" "359.3" "366.8" "365.5" "359.1" "508.2" "496.4" "496.7" "867.7" "" "" "" "" "" "" "" "" "" "" "327.7" "309.2" "313.5" "274.3" "304.7" "329.8" "429.5" "410.3" "455.6" "867.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6950247271112546932" "False" "High" "IsMasterProtein" "Q9H3N1" "Thioredoxin-related transmembrane protein 1 OS=Homo sapiens OX=9606 GN=TMX1 PE=1 SV=1" "0.000" "False" "9.049" "6" "2" "2" "2" "280" "31.8" "4.98" "6.90" "2" "stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085" "81542" "ENSG00000139921" "TMX1" "B2R7A4; hsa:81542; Q8N487; Q8NBN5; Q9H3N1; Q9Y4T6" "" "" "0" "0" "0.975" "0.912" "1.033" "0.993" "1.014" "1.001" "1.008" "0.965" "0.388" "173.8" "169.5" "158.4" "179.5" "172.5" "176.1" "173.9" "175.1" "167.7" "67.4" "" "" "" "" "" "" "" "" "" "" "154.1" "140.4" "138.2" "134.3" "143.8" "161.8" "147.0" "144.7" "153.8" "67.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818906983370151673" "False" "High" "IsMasterProtein" "Q8ND76" "Cyclin-Y OS=Homo sapiens OX=9606 GN=CCNY PE=1 SV=2" "0.000" "False" "9.013" "7" "2" "2" "2" "341" "39.3" "7.20" "7.98" "2" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134" "219771" "ENSG00000108100" "CCNY" "B7ZKX9; D3DRY9; hsa:219771; Q2M3V4; Q2TU96; Q6NT86; Q7Z4U7; Q8ND76; Q8TEX2; Q8TEX3; Q96M99; Q96P45" "" "" "0" "0" "1.111" "0.928" "1.268" "1.011" "0.945" "1.141" "1.043" "0.948" "0.919" "160.6" "178.3" "149.1" "203.7" "162.4" "151.7" "183.3" "167.5" "152.3" "147.6" "" "" "" "" "" "" "" "" "" "" "142.4" "147.7" "130.1" "152.4" "135.4" "139.3" "154.9" "138.4" "139.7" "147.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-942541566262454804" "False" "High" "IsMasterProtein" "Q9BRQ0" "Pygopus homolog 2 OS=Homo sapiens OX=9606 GN=PYGO2 PE=1 SV=2" "0.000" "False" "9.005" "4" "1" "1" "1" "406" "41.2" "7.28" "6.42" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf00628" "90780" "ENSG00000163348" "PYGO2" "hsa:90780; Q8WYZ4; Q96CY2; Q9BRQ0" "Deactivation of the beta-catenin transactivating complex; Formation of the beta-catenin:TCF transactivating complex" "1q21.1 copy number variation syndrome" "3" "0" "1.011" "1.039" "0.952" "0.984" "1.075" "1.003" "0.950" "1.049" "0.811" "152.7" "154.4" "158.7" "145.3" "150.2" "164.2" "153.2" "145.1" "160.2" "123.8" "" "" "" "" "" "" "" "" "" "" "135.4" "127.9" "138.4" "108.7" "125.2" "150.8" "129.5" "119.9" "146.9" "123.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.000" "False" "9.003" "4" "2" "2" "2" "395" "42.5" "4.86" "6.73" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "3" "0" "0.923" "0.878" "0.816" "0.911" "0.987" "0.920" "0.793" "0.839" "2.793" "187.7" "173.2" "164.9" "153.1" "171.1" "185.2" "172.7" "148.9" "157.4" "524.4" "" "" "" "" "" "" "" "" "" "" "166.5" "143.5" "143.9" "114.5" "142.7" "170.2" "146.0" "123.1" "144.4" "524.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7773792101669392702" "False" "High" "IsMasterProtein" "O94880" "PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=3" "0.000" "False" "9.001" "2" "2" "2" "2" "948" "106.9" "5.34" "6.65" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf13831, Pf13832" "9678" "ENSG00000106443" "PHF14" "A0A0U1RRH6; A7MCZ3; B4DI82; hsa:9678; O94880" "" "" "0" "0" "1.053" "1.004" "1.108" "1.055" "1.015" "0.997" "1.036" "0.826" "0.507" "228.6" "240.7" "229.5" "253.3" "241.1" "232.0" "227.9" "236.9" "188.8" "116.0" "" "" "" "" "" "" "" "" "" "" "202.7" "199.3" "200.2" "189.4" "201.1" "213.1" "192.7" "195.8" "173.2" "116.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3340255736931624389" "False" "High" "IsMasterProtein" "Q9UHA3" "Probable ribosome biogenesis protein RLP24 OS=Homo sapiens OX=9606 GN=RSL24D1 PE=1 SV=1" "0.000" "False" "8.999" "17" "2" "2" "2" "163" "19.6" "9.98" "7.34" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus" "other molecular function" "Pf01246" "51187" "ENSG00000137876" "RSL24D1" "B2RD72; hsa:51187; Q561V8; Q8N6S8; Q96B04; Q96C76; Q96HJ1; Q9UHA3" "" "" "0" "0" "1.157" "0.938" "0.969" "0.929" "1.011" "1.041" "1.018" "0.945" "0.317" "38.9" "45.1" "36.5" "37.8" "36.2" "39.4" "40.5" "39.7" "36.8" "12.3" "" "" "" "" "" "" "" "" "" "" "34.5" "37.3" "31.9" "28.2" "30.2" "36.2" "34.3" "32.8" "33.7" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3147119451307441974" "False" "High" "IsMasterProtein" "Q96MU7" "YTH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=YTHDC1 PE=1 SV=3" "0.000" "False" "8.992" "3" "3" "4" "3" "727" "84.6" "6.23" "11.05" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf04146" "91746" "ENSG00000083896; ENSG00000275272" "YTHDC1" "hsa:91746; Q4W5Q3; Q7Z622; Q8TF35; Q96MU7" "" "" "0" "0" "0.961" "0.966" "0.958" "0.869" "0.912" "0.797" "0.870" "0.775" "0.722" "198.2" "190.4" "191.5" "190.0" "172.2" "180.8" "158.0" "172.4" "153.7" "143.1" "" "" "" "" "" "" "" "" "" "" "175.8" "157.8" "167.1" "142.1" "143.6" "166.0" "133.5" "142.5" "140.9" "143.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "High" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.000" "False" "8.989" "0" "2" "2" "2" "3859" "437.3" "8.19" "8.21" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones" "Rett syndrome" "4" "0" "1.163" "0.877" "1.033" "1.026" "1.210" "1.021" "0.817" "1.106" "1.878" "160.5" "186.6" "140.7" "165.8" "164.7" "194.2" "163.8" "131.1" "177.4" "301.3" "" "" "" "" "" "" "" "" "" "" "142.3" "154.6" "122.8" "124.0" "137.3" "178.4" "138.4" "108.4" "162.7" "301.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "745274347307830124" "False" "High" "IsMasterProtein" "Q9BX70" "BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=BTBD2 PE=1 SV=1" "0.000" "False" "8.973" "3" "1" "1" "1" "525" "55.9" "5.90" "5.16" "1" "developmental processes" "cytosol;other cell component" "" "Pf00651, Pf07707, Pf08005" "55643" "ENSG00000133243" "BTBD2" "hsa:55643; O60418; O75248; Q4VBZ1; Q6IAC5; Q7Z5W0; Q96SX8; Q9BX70; Q9NPS1; Q9NX81" "" "" "0" "0" "1.170" "1.136" "1.077" "1.185" "1.193" "1.099" "1.061" "0.999" "2.182" "86.9" "101.7" "98.7" "93.5" "102.9" "103.6" "95.5" "92.2" "86.8" "189.6" "" "" "" "" "" "" "" "" "" "" "77.0" "84.2" "86.1" "70.0" "85.8" "95.2" "80.7" "76.2" "79.6" "189.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8546786530734250007" "False" "High" "IsMasterProtein" "Q00325" "Solute carrier family 25 member 3 OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2" "0.000" "False" "8.961" "9" "3" "4" "3" "362" "40.1" "9.38" "10.39" "3" "transport" "plasma membrane;other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00153" "5250" "ENSG00000075415" "SLC25A3" "B3KS34; hsa:5250; Q00325; Q7Z7N7; Q96A03" "" "" "0" "0" "1.279" "1.018" "1.162" "1.268" "1.360" "1.212" "1.090" "1.475" "0.661" "314.7" "402.5" "320.5" "365.5" "399.1" "427.8" "381.3" "342.9" "464.0" "208.0" "" "" "" "" "" "" "" "" "" "" "279.0" "333.4" "279.6" "273.3" "332.8" "393.0" "322.3" "283.4" "425.6" "208.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2186364449985292911" "False" "High" "IsMasterProtein" "P63172" "Dynein light chain Tctex-type 1 OS=Homo sapiens OX=9606 GN=DYNLT1 PE=1 SV=1" "0.000" "False" "8.957" "14" "1" "1" "1" "113" "12.4" "5.08" "6.03" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03645" "6993" "ENSG00000146425" "DYNLT1" "hsa:6993; P63172; Q15763; Q5VTU4" "Neutrophil degranulation" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "5" "0" "1.229" "1.136" "0.865" "1.174" "1.172" "1.166" "1.145" "1.206" "0.763" "124.6" "153.1" "141.6" "107.8" "146.4" "146.0" "145.4" "142.7" "150.2" "95.1" "" "" "" "" "" "" "" "" "" "" "110.5" "126.8" "123.6" "80.6" "122.0" "134.1" "122.9" "118.0" "137.8" "95.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623340480838481175" "False" "High" "IsMasterProtein" "Q15287" "RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1" "0.000" "False" "8.951" "5" "1" "2" "1" "305" "34.2" "11.84" "7.13" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10921" "ENSG00000205937" "RNPS1" "A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3" "Transport of Mature mRNA derived from an Intron-Containing Transcript; Regulation of expression of SLITs and ROBOs; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "mRNA processing" "7" "0" "1.099" "1.010" "1.203" "1.065" "1.079" "0.796" "0.856" "1.141" "1.648" "57.6" "63.4" "58.2" "69.3" "61.4" "62.2" "45.9" "49.4" "65.8" "95.0" "" "" "" "" "" "" "" "" "" "" "51.1" "52.5" "50.8" "51.8" "51.2" "57.2" "38.8" "40.8" "60.3" "95.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3711449830735196489" "False" "High" "IsMasterProtein" "Q9BZJ0" "Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4" "0.000" "False" "8.941" "5" "3" "3" "3" "848" "100.4" "8.00" "5.05" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf02184" "51340" "ENSG00000101343" "CRNKL1" "A8K9T4; hsa:51340; Q5JY64; Q8WYI5; Q9BZI9; Q9BZJ0; Q9BZJ1; Q9BZJ2; Q9GZW7; Q9H8F8; Q9NQH5; Q9NYD8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.092" "0.887" "1.015" "1.091" "0.808" "0.938" "0.898" "0.853" "0.641" "81.8" "89.3" "72.5" "83.0" "89.2" "66.1" "76.7" "73.5" "69.8" "52.5" "" "" "" "" "" "" "" "" "" "" "72.6" "74.0" "63.3" "62.1" "74.4" "60.7" "64.9" "60.7" "64.0" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "75736922320642282" "False" "High" "IsMasterProtein" "O95568" "Histidine protein methyltransferase 1 homolog OS=Homo sapiens OX=9606 GN=METTL18 PE=1 SV=1" "0.000" "False" "8.917" "10" "3" "3" "3" "372" "42.1" "6.76" "6.54" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13489" "92342" "ENSG00000171806" "METTL18" "B2R9T5; hsa:92342; O95568" "" "" "0" "0" "1.108" "0.662" "1.202" "0.794" "0.662" "1.212" "0.767" "0.704" "0.516" "156.1" "172.9" "103.4" "187.6" "123.9" "103.3" "189.2" "119.7" "109.9" "80.6" "" "" "" "" "" "" "" "" "" "" "138.4" "143.2" "90.2" "140.3" "103.3" "94.9" "159.9" "99.0" "100.8" "80.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243679290783972836" "False" "High" "IsMasterProtein" "Q5JPE7" "BOS complex subunit NOMO2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1" "0.000" "False" "8.911" "1" "2" "2" "2" "1267" "139.4" "5.76" "6.47" "2" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity;other molecular function" "Pf13620, Pf17802" "283820" "ENSG00000185164" "NOMO2" "hsa:283820; Q4G177; Q5JPE7" "" "" "0" "0" "1.137" "1.042" "1.212" "1.006" "1.200" "1.125" "1.079" "1.049" "0.997" "165.8" "188.6" "172.7" "201.1" "166.8" "199.0" "186.6" "178.9" "174.0" "165.3" "" "" "" "" "" "" "" "" "" "" "147.1" "156.2" "150.7" "150.4" "139.1" "182.8" "157.7" "147.9" "159.6" "165.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939280561053710644" "False" "High" "IsMasterProtein" "Q9P0T4" "Zinc finger protein 581 OS=Homo sapiens OX=9606 GN=ZNF581 PE=1 SV=1" "0.000" "False" "8.899" "11" "2" "2" "2" "197" "22.0" "8.82" "7.71" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "51545" "ENSG00000171425" "ZNF581" "B2RDM6; hsa:51545; Q9P0T4" "" "" "0" "0" "0.946" "0.793" "0.810" "0.835" "0.939" "0.832" "0.746" "0.720" "0.719" "198.7" "188.0" "157.5" "160.9" "165.9" "186.7" "165.2" "148.2" "143.0" "142.9" "" "" "" "" "" "" "" "" "" "" "176.2" "155.7" "137.4" "120.4" "138.4" "171.5" "139.6" "122.5" "131.1" "142.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583521273813264514" "False" "High" "IsMasterProtein" "P35236" "Tyrosine-protein phosphatase non-receptor type 7 OS=Homo sapiens OX=9606 GN=PTPN7 PE=1 SV=3" "0.000" "False" "8.889" "9" "3" "3" "3" "360" "40.5" "6.79" "9.52" "3" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5778" "ENSG00000143851" "PTPN7" "B3KXE1; hsa:5778; P35236; Q53XK4; Q5SXQ0; Q5SXQ1; Q9BV05" "Interleukin-37 signaling; Negative regulation of MAPK pathway" "MAPK signaling pathway; IL-18 signaling pathway" "4" "0" "1.146" "1.024" "1.143" "0.974" "0.942" "1.044" "0.769" "0.960" "4.005" "211.3" "242.3" "216.4" "241.5" "205.9" "199.1" "220.6" "162.5" "202.8" "846.4" "" "" "" "" "" "" "" "" "" "" "187.4" "200.7" "188.8" "180.6" "171.7" "182.9" "186.4" "134.3" "186.0" "846.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7946497630754715310" "False" "High" "IsMasterProtein" "Q9H223" "EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1" "0.000" "False" "8.886" "5" "3" "3" "2" "541" "61.1" "6.76" "8.70" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30844" "ENSG00000103966" "EHD4" "hsa:30844; Q9H223; Q9HAR1; Q9NZN2" "" "" "0" "0" "1.378" "0.900" "1.119" "1.320" "1.099" "1.278" "1.112" "1.172" "1.206" "210.3" "289.7" "189.3" "235.4" "277.5" "231.0" "268.7" "233.7" "246.5" "253.6" "" "" "" "" "" "" "" "" "" "" "186.5" "240.0" "165.1" "176.0" "231.4" "212.2" "227.1" "193.2" "226.1" "253.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6147929922391527183" "False" "High" "IsMasterProtein" "P49116" "Nuclear receptor subfamily 2 group C member 2 OS=Homo sapiens OX=9606 GN=NR2C2 PE=1 SV=1" "0.000" "False" "8.884" "5" "2" "3" "2" "596" "65.4" "6.28" "6.48" "2" "developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7182" "ENSG00000177463" "NR2C2" "A8K3H5; B6ZGT8; hsa:7182; P49116; P55092" "Nuclear Receptor transcription pathway" "Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer" "5" "0" "1.014" "0.964" "1.135" "0.928" "0.993" "0.863" "0.791" "0.849" "1.049" "249.8" "253.4" "240.8" "283.5" "231.9" "248.2" "215.7" "197.6" "212.2" "262.1" "" "" "" "" "" "" "" "" "" "" "221.5" "209.9" "210.1" "212.0" "193.4" "228.0" "182.3" "163.3" "194.6" "262.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.000" "False" "8.852" "11" "2" "3" "2" "163" "17.6" "10.30" "7.89" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.000" "False" "8.851" "14" "2" "3" "2" "138" "15.8" "9.60" "9.83" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.907" "0.958" "1.023" "0.974" "0.932" "0.967" "0.968" "0.888" "0.417" "418.9" "379.9" "401.2" "428.6" "407.8" "390.2" "405.0" "405.6" "372.1" "174.8" "" "" "" "" "" "" "" "" "" "" "371.4" "314.7" "350.1" "320.6" "340.1" "358.5" "342.3" "335.3" "341.3" "174.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5451664074513337477" "False" "High" "IsMasterProtein" "O75629" "Protein CREG1 OS=Homo sapiens OX=9606 GN=CREG1 PE=1 SV=1" "0.000" "False" "8.849" "10" "1" "1" "1" "220" "24.1" "7.59" "6.33" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13883" "8804" "ENSG00000143162" "CREG1" "B2RDD4; hsa:8804; O75629; Q8N9A3" "Neutrophil degranulation" "" "1" "0" "1.418" "1.389" "1.286" "1.455" "1.265" "1.318" "0.909" "1.127" "0.638" "38.3" "54.4" "53.3" "49.3" "55.8" "48.5" "50.6" "34.9" "43.2" "24.5" "" "" "" "" "" "" "" "" "" "" "34.0" "45.0" "46.5" "36.9" "46.5" "44.5" "42.7" "28.8" "39.6" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6220946712320524294" "False" "High" "IsMasterProtein" "Q7L5D6" "Golgi to ER traffic protein 4 homolog OS=Homo sapiens OX=9606 GN=GET4 PE=1 SV=1" "0.000" "False" "8.849" "6" "2" "2" "2" "327" "36.5" "5.41" "6.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04190" "51608" "ENSG00000239857" "GET4" "A4D2Q1; B3KNC7; hsa:51608; Q7L5D6; Q9UFC9; Q9Y309" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.061" "0.900" "0.954" "0.993" "0.940" "1.122" "1.086" "0.930" "3.678" "93.3" "98.9" "84.0" "89.0" "92.6" "87.7" "104.7" "101.3" "86.8" "343.1" "" "" "" "" "" "" "" "" "" "" "82.7" "81.9" "73.3" "66.6" "77.2" "80.6" "88.5" "83.7" "79.6" "343.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6216659800236310345" "False" "High" "IsMasterProtein" "Q9H1Z4" "WD repeat-containing protein 13 OS=Homo sapiens OX=9606 GN=WDR13 PE=1 SV=3" "0.000" "False" "8.847" "6" "2" "2" "2" "485" "53.7" "9.23" "10.01" "2" "other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus" "other molecular function" "Pf00400" "64743" "ENSG00000101940" "WDR13" "hsa:64743; Q06DW8; Q06DX0; Q06DX1; Q9BUL7; Q9H1Z4; Q9NWW4" "" "" "0" "0" "0.884" "0.789" "1.034" "0.928" "0.995" "1.163" "1.020" "0.787" "0.881" "118.7" "104.9" "93.6" "122.7" "110.1" "118.1" "138.0" "121.0" "93.4" "104.6" "" "" "" "" "" "" "" "" "" "" "105.2" "86.9" "81.7" "91.8" "91.8" "108.5" "116.7" "100.0" "85.7" "104.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8104731299280243918" "False" "High" "IsMasterProtein" "Q4G148" "Glucoside xylosyltransferase 1 OS=Homo sapiens OX=9606 GN=GXYLT1 PE=1 SV=2" "0.000" "False" "8.832" "5" "2" "2" "2" "440" "50.5" "8.65" "6.69" "2" "protein metabolism;other metabolic processes" "other membranes" "other molecular function" "Pf01501" "283464" "ENSG00000151233" "GXYLT1" "B3KWJ2; hsa:283464; Q4G148; Q8IXV1; Q96BH4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5300611953044969662" "False" "High" "IsMasterProtein" "Q9BSJ5" "Mitochondrial nucleoid-associated protein 1 OS=Homo sapiens OX=9606 GN=MTNAP1 PE=1 SV=2" "0.000" "False" "8.827" "4" "3" "5" "3" "609" "67.3" "9.16" "15.41" "3" "" "other membranes" "" "" "55028" "ENSG00000141219" "C17orf80" "A8K9X3; Q5JB45; Q6YAU3; Q9BSJ5; Q9H0L9; Q9H5E6; Q9NWN5" "" "" "0" "0" "0.992" "1.124" "0.943" "1.016" "1.012" "0.917" "0.980" "1.007" "0.422" "507.6" "503.6" "570.6" "478.5" "515.6" "513.8" "465.4" "497.6" "511.2" "214.3" "" "" "" "" "" "" "" "" "" "" "450.1" "417.2" "497.9" "357.8" "430.0" "472.0" "393.4" "411.3" "468.8" "214.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653544174487068262" "False" "High" "IsMasterProtein" "O00479" "High mobility group nucleosome-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=HMGN4 PE=1 SV=3" "0.000" "False" "8.819" "27" "3" "3" "3" "90" "9.5" "10.48" "10.41" "3" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "10473" "ENSG00000182952; ENSG00000292175" "HMGN4" "B2R4I6; hsa:10473; O00479; Q53XL9" "" "" "0" "0" "0.879" "0.803" "0.926" "0.812" "0.843" "0.949" "0.954" "0.924" "0.345" "787.2" "691.9" "632.0" "728.8" "639.1" "663.7" "747.4" "751.2" "727.8" "271.8" "" "" "" "" "" "" "" "" "" "" "698.1" "573.2" "551.5" "545.0" "532.9" "609.7" "631.7" "620.9" "667.4" "271.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755213045612558311" "False" "High" "IsMasterProtein" "P53367" "Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2" "0.000" "False" "8.812" "6" "2" "6" "2" "373" "41.7" "6.70" "11.07" "2" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf06456" "27236" "ENSG00000164144" "ARFIP1" "B4DS69; hsa:27236; P53367; Q2M2X4; Q3SYL4; Q9Y2X6" "" "" "0" "0" "0.935" "0.896" "1.024" "0.952" "1.072" "0.974" "1.003" "0.805" "0.887" "945.2" "883.3" "846.9" "968.3" "900.1" "1012.8" "921.0" "948.4" "760.6" "838.2" "" "" "" "" "" "" "" "" "" "" "838.2" "731.7" "739.0" "724.2" "750.6" "930.4" "778.4" "783.9" "697.6" "838.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9220853686183247090" "False" "High" "IsMasterProtein" "Cont_P01966" "Hemoglobin subunit alpha OS=Bos taurus OX=9913 GN=HBA PE=1 SV=2" "0.000" "True" "8.786" "11" "1" "1" "1" "142" "15.2" "8.44" "4.81" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "100140149; 109578761; 512439" "ENSBIXG00000028763; ENSBIXG00005026352; ENSBTAG00000051412" "GLNC1; HBA; LOC109578761; LOC113883300" "A0A1K0FUD3; A0A4W2IFB1; A0A6P5DZW6; A3KN13; biu:109578761; bta:100140149; bta:512439; P01966; Q3SZE0; Q9TTR9; Q9TTS0; Q9TTS1" "Cytoprotection by HMOX1; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Heme signaling; Erythrocytes take up oxygen and release carbon dioxide" "" "5" "0" "1.020" "1.143" "1.067" "1.218" "1.191" "0.976" "1.106" "1.009" "0.593" "116.1" "118.4" "132.7" "123.9" "141.4" "138.3" "113.3" "128.4" "117.2" "68.8" "" "" "" "" "" "" "" "" "" "" "103.0" "98.1" "115.8" "92.7" "117.9" "127.0" "95.8" "106.2" "107.5" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "418728153778102369" "False" "High" "IsMasterProtein" "Q13029" "PR domain zinc finger protein 2 OS=Homo sapiens OX=9606 GN=PRDM2 PE=1 SV=3" "0.000" "False" "8.782" "1" "3" "3" "3" "1718" "188.8" "7.31" "8.51" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912, Pf21549" "7799" "ENSG00000116731" "PRDM2" "B1AJZ4; B5MC68; hsa:7799; Q13029; Q13149; Q14550; Q5THJ1; Q5VUL9" "" "Histone modifications" "1" "0" "0.930" "0.705" "0.764" "0.650" "0.508" "0.496" "0.705" "0.758" "0.499" "490.0" "455.5" "345.3" "374.1" "318.5" "248.7" "242.8" "345.5" "371.4" "244.5" "" "" "" "" "" "" "" "" "" "" "434.5" "377.3" "301.3" "279.8" "265.6" "228.4" "205.2" "285.5" "340.6" "244.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1316883428224227619" "False" "High" "IsMasterProtein" "Q8WYQ5" "Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1" "0.000" "False" "8.765" "3" "2" "2" "2" "773" "86.0" "5.95" "5.04" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "54487" "ENSG00000128191" "DGCR8" "B2R8G1; hsa:54487; Q6DCB2; Q6MZE9; Q6Y2L0; Q8WYQ5; Q96G39; Q96GP8; Q9H6L8; Q9H6T7; Q9NRW2" "Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7993967056221403717" "False" "High" "IsMasterProtein" "Q9BU02" "Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3" "0.000" "False" "8.750" "10" "2" "2" "2" "230" "25.6" "4.82" "5.79" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01928" "79178" "ENSG00000259431" "THTPA" "D3DS50; G3V4J3; hsa:79178; Q9BU02" "Vitamin B1 (thiamin) metabolism" "" "1" "0" "0.902" "0.858" "0.848" "0.892" "0.677" "0.886" "0.688" "0.843" "1.125" "71.0" "64.1" "60.9" "60.2" "63.3" "48.1" "62.9" "48.8" "59.8" "79.9" "" "" "" "" "" "" "" "" "" "" "62.9" "53.1" "53.2" "45.0" "52.8" "44.1" "53.2" "40.3" "54.9" "79.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3086307340332827349" "False" "High" "IsMasterProtein" "Q9UL45" "Biogenesis of lysosome-related organelles complex 1 subunit 6 OS=Homo sapiens OX=9606 GN=BLOC1S6 PE=1 SV=1" "0.000" "False" "8.719" "9" "1" "1" "1" "172" "19.7" "6.40" "5.81" "1" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf14712" "26258" "ENSG00000104164" "BLOC1S6" "hsa:26258; Q9UL45" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "1.447" "0.901" "0.831" "1.127" "1.155" "0.982" "0.874" "1.308" "0.988" "97.9" "141.8" "88.2" "81.4" "110.4" "113.2" "96.2" "85.6" "128.2" "96.7" "" "" "" "" "" "" "" "" "" "" "86.9" "117.4" "77.0" "60.9" "92.1" "104.0" "81.3" "70.7" "117.5" "96.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531814392904203237" "False" "High" "IsMasterProtein" "P09884" "DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2" "0.000" "False" "8.718" "1" "2" "2" "2" "1462" "165.8" "5.85" "7.42" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08996, Pf12254" "5422" "ENSG00000101868" "POLA1" "hsa:5422; P09884; Q86UQ7" "Activation of the pre-replicative complex; Defective pyroptosis; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication" "13" "0" "1.029" "0.861" "1.126" "1.039" "0.854" "1.225" "0.833" "1.140" "5.290" "368.1" "378.9" "317.0" "414.4" "382.6" "314.2" "451.0" "306.6" "419.7" "1947.5" "" "" "" "" "" "" "" "" "" "" "326.4" "313.9" "276.6" "309.9" "319.1" "288.6" "381.2" "253.4" "384.9" "1947.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6067622255201761803" "False" "High" "IsMasterProtein" "O95059" "Ribonuclease P protein subunit p14 OS=Homo sapiens OX=9606 GN=RPP14 PE=1 SV=3" "0.000" "False" "8.708" "19" "3" "5" "3" "124" "13.7" "7.75" "12.58" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "11102" "ENSG00000163684" "RPP14" "O95059; Q53X97" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "1.033" "1.281" "0.965" "1.111" "1.325" "0.923" "1.208" "1.069" "0.695" "101.9" "105.2" "130.5" "98.3" "113.2" "134.9" "94.0" "123.1" "108.8" "70.8" "" "" "" "" "" "" "" "" "" "" "90.3" "87.1" "113.9" "73.5" "94.4" "124.0" "79.5" "101.7" "99.8" "70.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6130355325015870888" "False" "High" "IsMasterProtein" "Q9Y3E2" "BolA-like protein 1 OS=Homo sapiens OX=9606 GN=BOLA1 PE=1 SV=1" "0.000" "False" "8.707" "15" "2" "3" "2" "137" "14.3" "7.96" "12.48" "2" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf01722" "51027" "ENSG00000178096" "BOLA1" "B2R7K2; D3DUZ4; hsa:51027; Q5QNY0; Q9Y3E2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7077086371814425132" "False" "High" "IsMasterProtein" "Q9BU79" "Transmembrane protein 243 OS=Homo sapiens OX=9606 GN=TMEM243 PE=1 SV=1" "0.000" "False" "8.690" "16" "1" "1" "1" "118" "13.4" "8.18" "5.80" "1" "" "other membranes" "" "Pf10856" "79161" "ENSG00000135185" "TMEM243" "A4D1C6; B2R9I4; D6W5P1; hsa:79161; Q9BU79" "" "" "0" "0" "1.125" "1.199" "1.153" "1.268" "1.215" "1.162" "1.217" "1.252" "1.025" "187.6" "211.0" "225.1" "216.3" "237.9" "228.0" "218.1" "228.4" "234.9" "192.4" "" "" "" "" "" "" "" "" "" "" "166.4" "174.8" "196.4" "161.8" "198.4" "209.5" "184.3" "188.8" "215.5" "192.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8900361841491851768" "False" "High" "IsMasterProtein" "Q8N567" "Zinc finger CCHC domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ZCCHC9 PE=1 SV=2" "0.000" "False" "8.677" "6" "2" "3" "2" "271" "30.5" "9.17" "5.73" "2" "" "nucleus" "other molecular function" "Pf00098" "84240" "ENSG00000131732" "ZCCHC9" "B2RAE7; hsa:84240; Q8N567; Q9H027" "" "" "0" "0" "0.889" "0.680" "0.733" "0.635" "0.668" "0.552" "0.677" "0.682" "0.277" "453.5" "403.1" "308.4" "332.3" "287.7" "302.7" "250.4" "307.1" "309.5" "125.8" "" "" "" "" "" "" "" "" "" "" "402.1" "333.9" "269.1" "248.5" "239.9" "278.1" "211.6" "253.8" "283.8" "125.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626058579617190840" "False" "High" "IsMasterProtein" "Q5VYS8" "Terminal uridylyltransferase 7 OS=Homo sapiens OX=9606 GN=TUT7 PE=1 SV=1" "0.000" "False" "8.672" "2" "3" "4" "3" "1495" "171.1" "6.83" "8.45" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf03828, Pf16631, Pf19088" "79670" "ENSG00000083223" "TUT7" "hsa:79670; Q5H9T0; Q5VYS5; Q5VYS7; Q5VYS8; Q658Z9; Q659A2; Q6MZJ3; Q8N5F0; Q96N57; Q96NE8; Q9C0F2; Q9H8M6" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "3" "0" "1.021" "0.932" "1.321" "1.096" "0.908" "1.093" "0.193" "0.946" "12.690" "41.8" "42.7" "39.0" "55.3" "45.9" "38.0" "45.7" "8.1" "39.6" "530.9" "" "" "" "" "" "" "" "" "" "" "37.1" "35.4" "34.0" "41.3" "38.2" "34.9" "38.6" "6.7" "36.3" "530.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-763212604296308746" "False" "High" "IsMasterProtein" "Q8IXH7" "Negative elongation factor C/D OS=Homo sapiens OX=9606 GN=NELFCD PE=1 SV=2" "0.000" "False" "8.666" "4" "2" "2" "2" "590" "66.2" "5.10" "7.16" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04858" "51497" "ENSG00000101158" "NELFCD" "B4DE06; hsa:51497; Q8IXH7; Q9BYL2; Q9H405; Q9H888; Q9H8T3; Q9NVX5; Q9P029; Q9UGN1; Q9UGN2; Q9UGN3" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "16" "0" "1.116" "0.913" "1.120" "1.118" "0.992" "1.044" "0.631" "0.914" "7.728" "149.7" "167.0" "136.6" "167.6" "167.3" "148.5" "156.2" "94.5" "136.8" "1156.9" "" "" "" "" "" "" "" "" "" "" "132.7" "138.4" "119.2" "125.4" "139.5" "136.4" "132.1" "78.1" "125.4" "1156.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5887664116474982474" "False" "High" "IsMasterProtein" "Q9H6E4" "Coiled-coil domain-containing protein 134 OS=Homo sapiens OX=9606 GN=CCDC134 PE=1 SV=1" "0.000" "False" "8.649" "8" "1" "1" "1" "229" "26.5" "8.85" "6.34" "1" "developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf15002" "79879" "ENSG00000100147" "CCDC134" "hsa:79879; Q9H6E4" "" "" "0" "0" "1.124" "1.064" "1.189" "1.020" "0.925" "1.198" "1.049" "1.081" "2.017" "143.1" "160.9" "152.2" "170.1" "145.9" "132.3" "171.4" "150.0" "154.7" "288.6" "" "" "" "" "" "" "" "" "" "" "126.9" "133.3" "132.8" "127.2" "121.7" "121.6" "144.8" "124.0" "141.9" "288.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5248794698895072137" "False" "High" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "0.000" "False" "8.647" "5" "3" "3" "3" "651" "72.8" "7.44" "5.34" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8603881510889965526" "False" "High" "IsMasterProtein" "Q92889" "DNA repair endonuclease XPF OS=Homo sapiens OX=9606 GN=ERCC4 PE=1 SV=3" "0.000" "False" "8.624" "2" "2" "2" "2" "916" "104.4" "6.93" "6.98" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02732" "2072" "ENSG00000175595" "ERCC4" "A5PKV6; A8K111; hsa:2072; O00140; Q8TD83; Q92889" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "0.913" "0.887" "1.047" "0.723" "0.888" "0.955" "0.917" "0.764" "1.779" "228.5" "208.6" "202.5" "239.1" "165.1" "202.9" "218.2" "209.4" "174.5" "406.3" "" "" "" "" "" "" "" "" "" "" "202.6" "172.8" "176.7" "178.8" "137.7" "186.4" "184.4" "173.1" "160.1" "406.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904247061824975509" "False" "High" "IsMasterProtein" "Q9NP73" "UDP-N-acetylglucosamine transferase subunit ALG13 OS=Homo sapiens OX=9606 GN=ALG13 PE=1 SV=2" "0.000" "False" "8.603" "2" "2" "4" "2" "1137" "126.0" "6.74" "11.94" "2" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02338, Pf04101" "79868" "ENSG00000101901" "ALG13" "B1AKD6; B1AKM1; B2R5L5; B7Z6J0; B7Z804; B7Z847; B7Z9A8; B7ZAJ1; B7ZB57; hsa:79868; Q17RC3; Q5JXY9; Q9H5U8; Q9NP73" "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS" "N-glycan biosynthesis" "3" "0" "1.091" "0.967" "1.225" "1.085" "0.954" "1.043" "0.960" "0.966" "0.896" "166.2" "181.4" "160.7" "203.6" "180.4" "158.6" "173.4" "159.6" "160.5" "149.0" "" "" "" "" "" "" "" "" "" "" "147.4" "150.2" "140.2" "152.3" "150.4" "145.7" "146.6" "131.9" "147.2" "149.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1794400254837024545" "False" "High" "IsMasterProtein" "Q969P6" "DNA topoisomerase I, mitochondrial OS=Homo sapiens OX=9606 GN=TOP1MT PE=1 SV=1" "0.000" "False" "8.590" "4" "3" "3" "1" "601" "69.8" "9.41" "10.73" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01028, Pf02919, Pf14370" "116447" "ENSG00000184428" "TOP1MT" "B7ZAR5; E7ES89; hsa:116447; Q86ST4; Q86V82; Q969P6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-979600656900959777" "False" "High" "IsMasterProtein" "Q9HD40" "O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2" "0.000" "False" "8.586" "6" "3" "3" "3" "501" "55.7" "8.05" "7.83" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05889" "51091" "ENSG00000109618" "SEPSECS" "A8K8W1; hsa:51091; Q0D2P3; Q17RT1; Q9HD40; Q9NXZ5; Q9UGM9; Q9Y353" "Selenocysteine synthesis" "Selenium metabolism and selenoproteins" "2" "0" "0.889" "1.079" "1.218" "1.066" "1.195" "1.399" "1.342" "1.042" "3.656" "72.1" "64.1" "77.9" "87.9" "76.9" "86.2" "100.9" "96.8" "75.2" "263.7" "" "" "" "" "" "" "" "" "" "" "64.0" "53.1" "67.9" "65.7" "64.1" "79.2" "85.3" "80.0" "69.0" "263.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7212172965787635527" "False" "High" "IsMasterProtein" "Q15031" "Leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "0.000" "False" "8.575" "3" "3" "3" "3" "903" "101.9" "8.22" "8.30" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264, Pf13603" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Mitochondrial tRNA aminoacylation" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.000" "False" "8.564" "26" "3" "4" "3" "114" "13.5" "5.11" "10.96" "3" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "2" "0" "1.531" "0.670" "1.767" "1.108" "0.901" "1.618" "1.299" "0.979" "0.542" "26.6" "40.8" "17.8" "47.1" "29.5" "24.0" "43.1" "34.6" "26.1" "14.4" "" "" "" "" "" "" "" "" "" "" "23.6" "33.8" "15.6" "35.2" "24.6" "22.0" "36.4" "28.6" "23.9" "14.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7560300285237323007" "False" "High" "IsMasterProtein" "Q12980" "GATOR1 complex protein NPRL3 OS=Homo sapiens OX=9606 GN=NPRL3 PE=1 SV=1" "0.000" "False" "8.561" "3" "1" "1" "1" "569" "63.6" "6.98" "4.32" "1" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf03666" "8131" "ENSG00000103148" "NPRL3" "D3DU40; hsa:8131; Q12980; Q1W6H0; Q4TT56; Q92469" "Amino acids regulate mTORC1" "22q11.2 copy number variation syndrome" "2" "0" "0.704" "0.687" "0.896" "0.969" "0.987" "0.742" "0.949" "0.872" "3.351" "30.4" "21.4" "20.9" "27.3" "29.5" "30.0" "22.6" "28.9" "26.5" "102.0" "" "" "" "" "" "" "" "" "" "" "27.0" "17.7" "18.2" "20.4" "24.6" "27.6" "19.1" "23.9" "24.3" "102.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.000" "False" "8.557" "9" "3" "5" "3" "348" "38.6" "9.48" "13.31" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.872" "0.825" "0.877" "0.803" "0.753" "0.997" "0.765" "0.870" "2.339" "334.0" "291.3" "275.4" "292.8" "268.1" "251.4" "332.9" "255.5" "290.5" "781.1" "" "" "" "" "" "" "" "" "" "" "296.1" "241.3" "240.3" "219.0" "223.5" "231.0" "281.3" "211.2" "266.4" "781.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774466273942528480" "False" "High" "IsMasterProtein" "O43379" "WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4" "0.000" "False" "8.556" "2" "3" "3" "3" "1518" "165.8" "5.91" "9.46" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "" "Pf00400" "284403" "ENSG00000075702" "WDR62" "hsa:284403; O43379; Q63HP9; Q659D7; Q8NBF7; Q96AD9" "" "Primary ovarian insufficiency" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8446655200423982377" "False" "High" "IsMasterProtein" "Q8N4C8" "Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2" "0.000" "False" "8.556" "2" "2" "2" "1" "1332" "149.7" "7.85" "7.00" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "50488" "ENSG00000141503" "MINK1" "D3DTK3; D3DTK4; hsa:50488; Q5U8Z0; Q8N4C8; Q9P1X1; Q9P2R8" "Oxidative Stress Induced Senescence" "Angiopoietin-like protein 8 regulatory pathway; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "5" "0" "1.106" "1.111" "1.112" "1.054" "1.113" "1.337" "1.189" "1.234" "2.176" "95.6" "105.7" "106.2" "106.3" "100.8" "106.4" "127.8" "113.7" "118.0" "208.1" "" "" "" "" "" "" "" "" "" "" "84.8" "87.6" "92.7" "79.5" "84.0" "97.8" "108.0" "94.0" "108.2" "208.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5402441647647125323" "False" "High" "IsMasterProtein" "O75880" "Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1" "0.000" "False" "8.546" "8" "3" "3" "3" "301" "33.8" "8.88" "9.01" "3" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "6341" "ENSG00000133028" "SCO1" "B2RDM0; hsa:6341; O75880" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis" "5" "0" "1.020" "1.149" "1.122" "1.127" "1.211" "1.096" "1.065" "1.007" "0.661" "47.9" "48.9" "55.1" "53.8" "54.0" "58.0" "52.5" "51.1" "48.3" "31.7" "" "" "" "" "" "" "" "" "" "" "42.5" "40.5" "48.0" "40.2" "45.0" "53.3" "44.4" "42.2" "44.3" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8514110242710764604" "False" "High" "IsMasterProtein" "P48553" "Trafficking protein particle complex subunit 10 OS=Homo sapiens OX=9606 GN=TRAPPC10 PE=1 SV=2" "0.000" "False" "8.531" "2" "2" "2" "2" "1259" "142.1" "6.04" "3.75" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf12584" "7109" "ENSG00000160218" "TRAPPC10" "hsa:7109; P48553; Q3MIR2; Q86SI7; Q9UMD4; Q9Y4L3" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "0.991" "1.106" "1.062" "0.892" "0.928" "1.070" "0.866" "0.994" "1.244" "120.3" "119.2" "133.1" "127.8" "107.3" "111.7" "128.7" "104.2" "119.6" "149.7" "" "" "" "" "" "" "" "" "" "" "106.7" "98.7" "116.1" "95.6" "89.5" "102.6" "108.8" "86.1" "109.7" "149.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1664770674535561933" "False" "High" "IsMasterProtein" "Q96T37" "RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2" "0.000" "False" "8.529" "3" "2" "2" "2" "977" "107.1" "10.08" "7.63" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf07744" "64783" "ENSG00000162775" "RBM15" "A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0" "" "" "0" "0" "1.018" "1.022" "0.687" "1.223" "1.084" "1.014" "0.870" "1.099" "1.904" "26.6" "27.1" "27.2" "18.3" "32.6" "28.8" "27.0" "23.2" "29.3" "50.7" "" "" "" "" "" "" "" "" "" "" "23.6" "22.5" "23.7" "13.7" "27.1" "26.5" "22.8" "19.1" "26.8" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4950317330528062097" "False" "High" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.000" "False" "8.528" "3" "1" "1" "1" "427" "47.8" "9.47" "4.17" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Ub-specific processing proteases; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; DNA Damage Recognition in GG-NER" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465431971745530473" "False" "High" "IsMasterProtein" "Q3KRA9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Homo sapiens OX=9606 GN=ALKBH6 PE=1 SV=2" "0.000" "False" "8.526" "10" "3" "3" "3" "238" "26.5" "8.78" "8.32" "3" "" "nucleus;other cell component" "other molecular function" "Pf13532" "84964" "ENSG00000239382" "ALKBH6" "A5LGM8; A6NLP1; A8MU96; hsa:84964; Q3KRA9" "" "" "0" "0" "0.917" "0.919" "1.166" "1.155" "1.029" "1.079" "1.018" "0.969" "1.244" "103.0" "94.5" "94.7" "120.1" "119.1" "106.0" "111.2" "104.9" "99.9" "128.2" "" "" "" "" "" "" "" "" "" "" "91.4" "78.2" "82.6" "89.8" "99.3" "97.4" "94.0" "86.7" "91.6" "128.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171781996039323562" "False" "High" "IsMasterProtein" "P57105" "Synaptojanin-2-binding protein OS=Homo sapiens OX=9606 GN=SYNJ2BP PE=1 SV=2" "0.000" "False" "8.520" "10" "1" "1" "1" "145" "15.9" "6.30" "4.66" "1" "signal transduction;other biological processes" "other membranes;mitochondrion" "" "Pf00595" "55333" "ENSG00000213463" "SYNJ2BP" "hsa:55333; P57105; Q49SH3; Q96IA4" "" "" "0" "0" "1.899" "1.023" "1.800" "1.400" "1.577" "1.366" "1.408" "1.327" "0.747" "84.5" "160.4" "86.4" "152.0" "118.2" "133.2" "115.4" "118.9" "112.1" "63.1" "" "" "" "" "" "" "" "" "" "" "74.9" "132.9" "75.4" "113.7" "98.6" "122.4" "97.6" "98.3" "102.8" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "8.494" "2" "3" "3" "3" "1192" "132.5" "6.19" "9.72" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "Post-chaperonin tubulin folding pathway" "" "1" "0" "0.982" "0.975" "1.098" "0.984" "0.899" "1.252" "1.083" "0.979" "3.623" "137.1" "134.6" "133.7" "150.5" "134.9" "123.2" "171.6" "148.4" "134.2" "496.6" "" "" "" "" "" "" "" "" "" "" "121.6" "111.5" "116.6" "112.6" "112.5" "113.2" "145.0" "122.7" "123.1" "496.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6620394605716673272" "False" "High" "IsMasterProtein" "Q96GX2" "Ataxin-7-like protein 3B OS=Homo sapiens OX=9606 GN=ATXN7L3B PE=1 SV=2" "0.000" "False" "8.492" "10" "1" "4" "1" "97" "10.8" "4.36" "15.48" "1" "other biological processes" "other cell component" "" "" "552889" "ENSG00000253719" "ATXN7L3B" "hsa:552889; Q96GX2" "" "" "0" "0" "1.042" "1.062" "1.003" "0.993" "1.096" "1.008" "1.040" "1.007" "0.762" "679.4" "708.2" "721.6" "681.2" "674.9" "744.5" "685.0" "706.8" "683.9" "517.7" "" "" "" "" "" "" "" "" "" "" "602.5" "586.7" "629.6" "509.4" "562.8" "683.9" "579.0" "584.2" "627.2" "517.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654378889917812669" "False" "High" "IsMasterProtein" "Q9BQ90" "Kelch domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KLHDC3 PE=1 SV=1" "0.000" "False" "8.490" "7" "2" "2" "2" "382" "43.1" "8.07" "7.12" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf07646, Pf13418, Pf13964" "116138" "ENSG00000124702" "KLHDC3" "A8K2W9; hsa:116138; Q9BQ90" "XBP1(S) activates chaperone genes" "" "1" "0" "1.079" "1.096" "1.166" "1.091" "1.061" "1.144" "1.027" "1.015" "1.065" "310.0" "334.4" "339.8" "361.4" "338.2" "328.9" "354.5" "318.2" "314.6" "330.2" "" "" "" "" "" "" "" "" "" "" "274.9" "277.0" "296.5" "270.3" "282.0" "302.1" "299.6" "263.0" "288.6" "330.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8029509769443933574" "False" "High" "IsMasterProtein" "Q7Z7A3" "Cytoplasmic tRNA 2-thiolation protein 1 OS=Homo sapiens OX=9606 GN=CTU1 PE=1 SV=1" "0.000" "False" "8.489" "6" "2" "2" "2" "348" "36.4" "9.20" "8.29" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01171, Pf16503" "90353" "ENSG00000142544" "CTU1" "A8K558; hsa:90353; Q7Z7A3; Q96GZ7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.159" "0.986" "1.124" "1.088" "0.989" "1.017" "1.072" "0.824" "1.315" "136.6" "158.4" "134.7" "153.6" "148.6" "135.2" "139.0" "146.4" "112.6" "179.6" "" "" "" "" "" "" "" "" "" "" "121.2" "131.2" "117.5" "114.9" "123.9" "124.2" "117.5" "121.0" "103.3" "179.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5711081481514943927" "False" "High" "IsMasterProtein" "P07858" "Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3" "0.000" "False" "8.486" "9" "3" "3" "3" "339" "37.8" "6.30" "9.58" "3" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112, Pf08127" "1508" "ENSG00000164733; ENSG00000285132" "CTSB" "B3KQR5; B3KRR5; hsa:1508; P07858; Q503A6; Q96D87" "MHC class II antigen presentation; Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Neutrophil degranulation; Trafficking and processing of endosomal TLR" "Ebola virus infection in host; 8p23.1 copy number variation syndrome" "7" "0" "0.973" "0.991" "0.950" "0.997" "0.791" "0.930" "0.934" "0.698" "0.551" "35.3" "34.4" "35.0" "33.6" "35.3" "28.0" "32.9" "33.0" "24.7" "19.5" "" "" "" "" "" "" "" "" "" "" "31.3" "28.5" "30.6" "25.1" "29.4" "25.7" "27.8" "27.3" "22.6" "19.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588052474242389854" "False" "High" "IsMasterProtein" "Q92766" "Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3" "0.000" "False" "8.484" "2" "4" "5" "4" "1687" "181.3" "6.98" "10.84" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894, Pf13912" "6239" "ENSG00000124782" "RREB1" "A2RRF5; E2GM80; E2GM81; hsa:6239; O75567; O75568; Q5VYB2; Q6BEP5; Q6BEP6; Q6BEP8; Q86SU2; Q92766; Q9Y474" "" "" "0" "0" "0.914" "1.038" "0.918" "0.927" "0.892" "0.977" "0.845" "0.827" "1.059" "464.4" "424.5" "482.1" "426.3" "430.6" "414.1" "453.9" "392.5" "384.0" "491.8" "" "" "" "" "" "" "" "" "" "" "411.9" "351.7" "420.6" "318.8" "359.1" "380.4" "383.7" "324.4" "352.2" "491.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4453552053953244697" "False" "High" "IsMasterProtein" "P19634" "Sodium/hydrogen exchanger 1 OS=Homo sapiens OX=9606 GN=SLC9A1 PE=1 SV=2" "0.000" "False" "8.483" "3" "1" "1" "1" "815" "90.7" "7.21" "5.42" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf00999, Pf16644" "6548" "ENSG00000090020" "SLC9A1" "B1ALD6; D3DPL4; hsa:6548; P19634; Q96EM2" "Hyaluronan uptake and degradation; Sodium/Proton exchangers" "Osteoclast signaling; G protein signaling pathways; Gastrin signaling pathway; Opioid receptor pathways; Regulation of actin cytoskeleton" "7" "0" "1.253" "0.975" "1.302" "1.371" "1.124" "1.232" "1.147" "0.885" "0.833" "39.3" "49.3" "38.3" "51.2" "53.9" "44.2" "48.4" "45.1" "34.8" "32.7" "" "" "" "" "" "" "" "" "" "" "34.9" "40.8" "33.4" "38.3" "44.9" "40.6" "40.9" "37.3" "31.9" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396014057802155010" "False" "High" "IsMasterProtein" "Q15910" "Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2" "0.000" "False" "8.474" "4" "2" "2" "2" "746" "85.3" "7.02" "6.19" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf11616, Pf18118, Pf18264, Pf21358" "2146" "ENSG00000106462" "EZH2" "B2RAQ1; B3KS30; B7Z1D6; B7Z7L6; hsa:2146; Q15755; Q15910; Q75MG3; Q92857; Q96FI6" "Defective pyroptosis; Oxidative Stress Induced Senescence; HCMV Early Events; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "19" "0" "1.079" "0.877" "1.000" "1.047" "1.020" "0.861" "0.720" "0.966" "4.996" "90.5" "97.6" "79.4" "90.5" "94.8" "92.4" "77.9" "65.2" "87.5" "452.3" "" "" "" "" "" "" "" "" "" "" "80.3" "80.9" "69.3" "67.7" "79.0" "84.9" "65.9" "53.9" "80.2" "452.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2478117011496918927" "False" "High" "IsMasterProtein" "Q13206" "Probable ATP-dependent RNA helicase DDX10 OS=Homo sapiens OX=9606 GN=DDX10 PE=1 SV=2" "0.000" "False" "8.466" "2" "1" "1" "1" "875" "100.8" "8.63" "5.24" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf13959" "1662" "ENSG00000178105" "DDX10" "B2RCQ3; hsa:1662; Q13206; Q5BJD8" "" "" "0" "0" "1.142" "1.067" "1.142" "0.999" "1.334" "1.404" "0.807" "1.129" "0.820" "30.3" "34.6" "32.3" "34.6" "30.3" "40.4" "42.6" "24.5" "34.2" "24.9" "" "" "" "" "" "" "" "" "" "" "26.9" "28.7" "28.2" "25.9" "25.2" "37.2" "36.0" "20.2" "31.4" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8066723703653811047" "False" "High" "IsMasterProtein" "P53814" "Smoothelin OS=Homo sapiens OX=9606 GN=SMTN PE=1 SV=7" "0.000" "False" "8.465" "3" "3" "3" "3" "917" "99.0" "9.07" "8.56" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf12510" "6525" "ENSG00000183963" "SMTN" "hsa:6525; O00569; O95769; O95937; P53814; Q8N4H8; Q8WWW1; Q8WWW2; Q9P1S8; Q9UIT1; Q9UIT2" "" "" "0" "0" "0.914" "0.925" "0.855" "0.856" "0.891" "0.822" "0.788" "1.008" "2.214" "250.1" "228.7" "231.3" "213.9" "214.0" "222.8" "205.7" "197.2" "252.0" "553.6" "" "" "" "" "" "" "" "" "" "" "221.8" "189.4" "201.9" "159.9" "178.4" "204.7" "173.8" "163.0" "231.1" "553.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658722355380059482" "False" "High" "IsMasterProtein" "Q9UPN4" "Centrosomal protein of 131 kDa OS=Homo sapiens OX=9606 GN=CEP131 PE=1 SV=3" "0.000" "False" "8.457" "1" "1" "1" "1" "1083" "122.1" "8.69" "4.41" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22994" "ENSG00000141577" "CEP131" "A6NHI8; B2RN11; hsa:22994; Q96F50; Q9UPN4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.084" "1.199" "1.199" "1.113" "1.197" "1.278" "1.282" "1.029" "0.896" "40.9" "44.3" "49.0" "49.0" "45.5" "48.9" "52.2" "52.4" "42.1" "36.6" "" "" "" "" "" "" "" "" "" "" "36.2" "36.7" "42.8" "36.6" "37.9" "44.9" "44.1" "43.3" "38.6" "36.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1918127686378148163" "False" "High" "IsMasterProtein" "P20908" "Collagen alpha-1(V) chain OS=Homo sapiens OX=9606 GN=COL5A1 PE=1 SV=3" "0.000" "False" "8.435" "2" "3" "3" "3" "1838" "183.4" "5.06" "6.07" "3" "cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf01391, Pf01410, Pf02210" "1289" "ENSG00000130635" "COL5A1" "A0A087WXW9; hsa:1289; P20908; Q15094; Q5SUX4" "Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling" "Allograft rejection; miRNA targets in ECM and membrane receptors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403142608945012148" "False" "High" "IsMasterProtein" "Q8IX01" "SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2" "0.000" "False" "8.430" "2" "2" "2" "2" "1082" "120.1" "7.28" "5.69" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "10147" "ENSG00000064607" "SUGP2" "C9JI71; hsa:10147; O15071; O60369; Q5JPH7; Q8IX01; Q8WUF7" "" "mRNA processing" "1" "0" "1.012" "0.979" "1.212" "1.067" "1.082" "1.057" "0.941" "0.877" "2.208" "81.7" "82.7" "80.0" "99.1" "87.2" "88.4" "86.4" "76.9" "71.7" "180.5" "" "" "" "" "" "" "" "" "" "" "72.5" "68.5" "69.8" "74.1" "72.8" "81.2" "73.0" "63.6" "65.8" "180.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534484608378348231" "False" "High" "IsMasterProtein" "Q9H000" "E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens OX=9606 GN=MKRN2 PE=1 SV=2" "0.000" "False" "8.422" "9" "4" "4" "4" "416" "46.9" "7.61" "12.75" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00097, Pf00642, Pf14608" "23609" "ENSG00000075975" "MKRN2" "A6NIA2; B3KRC5; B4DPR4; Q8N391; Q96BD4; Q9BUY2; Q9H000; Q9NRY1" "" "" "0" "0" "1.036" "0.989" "1.084" "1.040" "1.068" "0.832" "0.422" "0.946" "9.346" "229.6" "238.0" "227.1" "248.8" "238.8" "245.2" "191.1" "96.8" "217.1" "2145.7" "" "" "" "" "" "" "" "" "" "" "203.6" "197.1" "198.1" "186.1" "199.1" "225.2" "161.5" "80.0" "199.1" "2145.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5495353831656127209" "False" "High" "IsMasterProtein" "Q8ND04" "Nonsense-mediated mRNA decay factor SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1" "0.000" "False" "8.421" "3" "3" "3" "3" "991" "109.6" "7.68" "7.25" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf10220" "55181" "ENSG00000167447" "SMG8" "hsa:55181; Q8N5U5; Q8ND04; Q8TDN0; Q9H5P5; Q9NVQ1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "1.102" "0.739" "1.012" "0.866" "0.713" "0.909" "0.010" "0.930" "19.165" "27.3" "30.1" "20.2" "27.6" "23.6" "19.5" "24.8" "0.0" "25.4" "523.0" "" "" "" "" "" "" "" "" "" "" "24.2" "24.9" "17.6" "20.7" "19.7" "17.9" "21.0" "0.0" "23.3" "523.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5558995711693310036" "False" "High" "IsMasterProtein" "Q9BWW4" "Single-stranded DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=SSBP3 PE=1 SV=1" "0.000" "False" "8.419" "5" "2" "3" "2" "388" "40.4" "6.90" "10.65" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04503" "23648" "ENSG00000157216" "SSBP3" "A8K0A9; hsa:23648; Q5T860; Q5T861; Q9BTM0; Q9BWW3; Q9BWW4" "" "" "0" "0" "0.858" "0.930" "0.831" "0.777" "0.727" "0.689" "0.754" "0.984" "0.471" "262.7" "225.3" "244.4" "218.1" "204.2" "191.0" "181.0" "197.9" "258.5" "123.8" "" "" "" "" "" "" "" "" "" "" "232.9" "186.7" "213.2" "163.1" "170.3" "175.4" "152.9" "163.6" "237.1" "123.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6077742637667714135" "False" "High" "IsMasterProtein" "Q00535" "Cyclin-dependent kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "0.000" "False" "8.417" "14" "3" "3" "2" "292" "33.3" "7.66" "5.52" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; DARPP-32 events; Activated NTRK2 signals through CDK5" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "16" "0" "1.056" "0.975" "1.653" "1.114" "0.887" "1.149" "0.914" "0.880" "0.963" "235.5" "248.8" "229.6" "389.3" "262.4" "209.0" "270.5" "215.3" "207.3" "226.8" "" "" "" "" "" "" "" "" "" "" "208.9" "206.1" "200.3" "291.1" "218.8" "192.0" "228.6" "178.0" "190.1" "226.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4484612190120374131" "False" "High" "IsMasterProtein" "Q9Y6Y0" "Influenza virus NS1A-binding protein OS=Homo sapiens OX=9606 GN=IVNS1ABP PE=1 SV=3" "0.000" "False" "8.415" "4" "3" "3" "3" "642" "71.7" "5.53" "5.62" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10625" "ENSG00000116679" "IVNS1ABP" "A8K8R6; hsa:10625; Q1G4T6; Q1G4T7; Q5TF75; Q6NW38; Q7LCG2; Q9NZX0; Q9Y480; Q9Y6Y0" "" "" "0" "0" "1.148" "1.111" "0.895" "1.099" "0.925" "1.016" "0.473" "0.848" "6.239" "36.2" "41.5" "40.2" "32.4" "39.8" "33.5" "36.8" "17.1" "30.7" "225.8" "" "" "" "" "" "" "" "" "" "" "32.1" "34.4" "35.1" "24.2" "33.2" "30.7" "31.1" "14.2" "28.2" "225.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1373534053104032037" "False" "High" "IsMasterProtein" "O14653" "Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2" "0.000" "False" "8.409" "10" "2" "2" "2" "212" "24.8" "8.06" "7.56" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf12352" "9570" "ENSG00000108433" "GOSR2" "D3DXJ5; D3DXJ6; hsa:9570; O14653; Q8N4B8; Q96DA5; Q9BZZ4" "COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5414288998537041680" "False" "High" "IsMasterProtein" "Q9UK53" "Inhibitor of growth protein 1 OS=Homo sapiens OX=9606 GN=ING1 PE=1 SV=2" "0.000" "False" "8.408" "6" "2" "2" "2" "422" "46.7" "9.06" "8.47" "2" "cell cycle OR cell proliferation;transport;other biological processes" "nucleus" "other molecular function" "Pf12998" "3621" "ENSG00000153487" "ING1" "hsa:3621; O00532; O43658; Q53ZR3; Q5T9G8; Q5T9G9; Q5T9H0; Q5T9H1; Q9H007; Q9HD98; Q9HD99; Q9NS83; Q9P0U6; Q9UBC6; Q9UIJ1; Q9UIJ2; Q9UIJ3; Q9UIJ4; Q9UK52; Q9UK53" "" "" "0" "0" "0.936" "0.969" "0.881" "0.901" "0.899" "0.987" "0.893" "0.926" "1.908" "150.3" "140.7" "145.6" "132.4" "135.4" "135.1" "148.3" "134.2" "139.2" "286.7" "" "" "" "" "" "" "" "" "" "" "133.3" "116.6" "127.1" "99.0" "112.9" "124.1" "125.3" "110.9" "127.6" "286.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3817415269467879151" "False" "High" "IsMasterProtein" "P16435" "NADPH--cytochrome P450 reductase OS=Homo sapiens OX=9606 GN=POR PE=1 SV=2" "0.000" "False" "8.400" "3" "2" "2" "2" "677" "76.6" "5.58" "6.39" "2" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "5447" "ENSG00000127948" "POR" "P16435; Q16455; Q197M5; Q8N181; Q9H3M8; Q9UDT3" "Cytochrome P450 - arranged by substrate type" "Oxidation by cytochrome P450; Ferroptosis; 7q11.23 distal copy number variation" "4" "0" "1.344" "1.446" "1.464" "1.375" "1.400" "1.578" "1.543" "1.376" "0.854" "57.0" "76.7" "82.5" "83.5" "78.4" "79.9" "90.0" "88.0" "78.5" "48.7" "" "" "" "" "" "" "" "" "" "" "50.6" "63.5" "71.9" "62.5" "65.4" "73.4" "76.1" "72.7" "72.0" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545380139494389775" "False" "High" "IsMasterProtein" "P08962" "CD63 antigen OS=Homo sapiens OX=9606 GN=CD63 PE=1 SV=2" "0.000" "False" "8.395" "8" "2" "2" "2" "238" "25.6" "7.81" "7.51" "2" "cell adhesion;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00335" "967" "ENSG00000135404" "CD63" "F8VZE2; hsa:967; P08962; Q5TZP3; Q8N6Z9; Q9UCG6" "Neutrophil degranulation; Platelet degranulation" "Extracellular vesicles in the crosstalk of cardiac cells; 11p11.2 copy number variation syndrome" "4" "0" "1.060" "0.990" "0.969" "1.043" "1.203" "1.145" "1.122" "1.245" "0.764" "284.4" "301.4" "281.7" "275.7" "296.6" "342.3" "325.6" "319.2" "354.2" "217.4" "" "" "" "" "" "" "" "" "" "" "252.2" "249.7" "245.8" "206.2" "247.3" "314.4" "275.2" "263.8" "324.9" "217.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3323196945052743606" "False" "High" "IsMasterProtein" "Q9UGC7" "Peptide chain release factor 1-like, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1L PE=1 SV=1" "0.000" "False" "8.380" "7" "2" "2" "2" "380" "43.6" "8.34" "7.77" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf00472, Pf03462" "54516" "ENSG00000112031" "MTRF1L" "B3KTA0; hsa:54516; Q3KR06; Q5TF44; Q5TF50; Q96CC5; Q96EX4; Q96K40; Q9UGC7" "Mitochondrial translation termination" "" "1" "0" "1.074" "1.043" "1.459" "1.076" "1.045" "1.069" "0.996" "1.076" "0.884" "172.1" "184.7" "179.4" "251.1" "185.1" "179.7" "184.0" "171.4" "185.2" "152.1" "" "" "" "" "" "" "" "" "" "" "152.6" "153.0" "156.6" "187.8" "154.3" "165.1" "155.5" "141.7" "169.9" "152.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2190048182398586679" "False" "High" "IsMasterProtein" "Q9NRX5" "Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1" "0.000" "False" "8.366" "4" "2" "2" "2" "453" "50.5" "5.85" "7.37" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf03348" "57515" "ENSG00000111897" "SERINC1" "B3KY69; E1P565; hsa:57515; O75655; Q7Z2F5; Q8TAG1; Q9NRX5; Q9NTH8; Q9ULG7" "Serine biosynthesis" "Sphingolipid pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "649692950129023278" "False" "High" "IsMasterProtein" "Q96QF0" "Rab-3A-interacting protein OS=Homo sapiens OX=9606 GN=RAB3IP PE=1 SV=1" "0.000" "False" "8.363" "3" "1" "1" "1" "476" "53.0" "5.97" "5.76" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf06428" "117177" "ENSG00000127328" "RAB3IP" "B7WPJ6; hsa:117177; Q6PCE4; Q96A24; Q96QE6; Q96QE7; Q96QE8; Q96QE9; Q96QF0; Q96QF1; Q9H673" "Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; BBSome-mediated cargo-targeting to cilium; VxPx cargo-targeting to cilium" "Joubert syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1234088544826657040" "False" "High" "IsMasterProtein" "Q9H871" "E3 ubiquitin-protein transferase RMND5A OS=Homo sapiens OX=9606 GN=RMND5A PE=1 SV=1" "0.000" "False" "8.356" "7" "3" "3" "3" "391" "44.0" "6.06" "6.78" "3" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10607, Pf13445" "64795" "ENSG00000153561" "RMND5A" "D6W5M6; hsa:64795; Q6NTF0; Q9H6W5; Q9H871; Q9H9H2" "" "Ciliary landscape" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765890645847651977" "False" "High" "IsMasterProtein" "Q14790" "Caspase-8 OS=Homo sapiens OX=9606 GN=CASP8 PE=1 SV=1" "0.000" "False" "8.342" "4" "1" "1" "1" "479" "55.4" "5.10" "5.14" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00656, Pf01335" "841" "ENSG00000064012" "CASP8" "hsa:841; O14676; Q14790; Q14791; Q14792; Q14793; Q14794; Q14795; Q14796; Q15780; Q15806; Q53TT5; Q8TDI1; Q8TDI2; Q8TDI3; Q8TDI4; Q8TDI5; Q96T22; Q9C0K4; Q9UQ81" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Regulation of NF-kappa B signaling; TLR3-mediated TICAM1-dependent programmed cell death; Caspase-mediated cleavage of cytoskeletal proteins; TNFR1-induced proapoptotic signaling; CLEC7A/inflammasome pathway; Microbial modulation of RIPK1-mediated regulated necrosis; Activation, myristolyation of BID and translocation to mitochondria; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; 16p11.2 proximal deletion syndrome; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Alzheimer's disease; DNA damage response; Toll-like receptor signaling pathway" "54" "0" "1.317" "1.001" "1.389" "1.387" "1.095" "1.187" "0.576" "1.309" "9.001" "45.2" "59.5" "45.2" "62.8" "62.7" "49.5" "53.6" "26.0" "59.1" "406.7" "" "" "" "" "" "" "" "" "" "" "40.1" "49.3" "39.5" "46.9" "52.3" "45.4" "45.3" "21.5" "54.2" "406.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "96752444028096472" "False" "High" "IsMasterProtein" "Q8WWC4" "m-AAA protease-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MAIP1 PE=1 SV=1" "0.000" "False" "8.311" "9" "3" "3" "3" "291" "32.5" "9.17" "9.24" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "translation activity" "" "79568" "ENSG00000162972" "MAIP1" "hsa:79568; Q658V9; Q8WWC4; Q9H671" "Processing of SMDT1" "" "1" "0" "0.966" "0.924" "0.939" "1.051" "1.049" "1.111" "1.035" "1.063" "1.731" "229.8" "222.0" "212.4" "215.7" "241.6" "241.1" "255.2" "237.9" "244.3" "397.9" "" "" "" "" "" "" "" "" "" "" "203.8" "183.9" "185.4" "161.3" "201.5" "221.5" "215.7" "196.7" "224.1" "397.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2106052778808331693" "False" "High" "IsMasterProtein" "P62910" "Large ribosomal subunit protein eL32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "0.000" "False" "8.309" "15" "2" "2" "2" "135" "15.9" "11.33" "6.58" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.960" "0.978" "1.057" "1.112" "1.120" "0.959" "0.994" "0.945" "1.151" "336.1" "322.8" "328.9" "355.3" "373.6" "376.3" "322.3" "334.0" "317.6" "386.9" "" "" "" "" "" "" "" "" "" "" "298.1" "267.4" "287.0" "265.7" "311.5" "345.7" "272.4" "276.1" "291.3" "386.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6975188446723822093" "False" "High" "IsMasterProtein" "O75771" "DNA repair protein RAD51 homolog 4 OS=Homo sapiens OX=9606 GN=RAD51D PE=1 SV=1" "0.000" "False" "8.295" "4" "1" "1" "1" "328" "35.0" "6.25" "5.09" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf08423, Pf21794" "5892" "ENSG00000185379" "RAD51D" "B4DJU7; E1P637; hsa:5892; O43537; O60355; O75196; O75771; O75847; O75848; O76073; O76085; O94908; Q9UFU5" "Resolution of D-loop Structures through Holliday Junction Intermediates; TP53 Regulates Transcription of DNA Repair Genes; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "17q12 copy number variation syndrome" "11" "0" "0.952" "0.931" "1.212" "1.270" "1.155" "1.416" "1.439" "1.085" "0.872" "85.0" "81.0" "79.1" "103.1" "108.0" "98.3" "120.4" "122.3" "92.3" "74.2" "" "" "" "" "" "" "" "" "" "" "75.4" "67.1" "69.1" "77.1" "90.1" "90.3" "101.8" "101.1" "84.6" "74.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8718116979404921777" "False" "High" "IsMasterProtein" "P51116" "RNA-binding protein FXR2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2" "0.000" "False" "8.263" "4" "3" "3" "2" "673" "74.2" "6.23" "9.50" "3" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf17904, Pf18336" "9513" "ENSG00000129245" "FXR2" "B2R9M2; D3DTQ1; hsa:9513; P51116; Q86V09; Q8WUM2" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.917" "0.835" "0.951" "0.804" "0.890" "0.900" "0.871" "0.861" "1.844" "159.4" "146.1" "133.1" "151.6" "128.2" "141.8" "143.5" "138.8" "137.2" "293.8" "" "" "" "" "" "" "" "" "" "" "141.3" "121.0" "116.2" "113.4" "106.9" "130.3" "121.3" "114.8" "125.8" "293.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7515824926889841061" "False" "High" "IsMasterProtein" "Q8TDM0" "Breast carcinoma-amplified sequence 4 OS=Homo sapiens OX=9606 GN=BCAS4 PE=1 SV=1" "0.000" "False" "8.237" "13" "2" "2" "2" "211" "22.7" "5.86" "6.71" "2" "" "other cell component" "" "" "55653" "ENSG00000124243" "BCAS4" "hsa:55653; Q5TD52; Q5TD53; Q5TD54; Q5U5K7; Q5XKE8; Q8IXI7; Q8NEZ6; Q8TDL9; Q8TDM0; Q9NX13; Q9Y511" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8080322362920288108" "False" "High" "IsMasterProtein" "Q7Z7F0" "KH homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KHDC4 PE=1 SV=1" "0.000" "False" "8.234" "4" "3" "3" "3" "614" "64.8" "8.73" "9.71" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "" "22889" "ENSG00000132680" "KHDC4" "hsa:22889; O94981; Q7L7Q2; Q7Z7E9; Q7Z7F0; Q8TBQ0" "" "" "0" "0" "0.939" "0.950" "1.013" "0.925" "0.945" "0.969" "0.986" "0.978" "2.292" "250.0" "234.8" "237.5" "253.2" "231.2" "236.3" "242.3" "246.5" "244.5" "573.0" "" "" "" "" "" "" "" "" "" "" "221.7" "194.5" "207.2" "189.3" "192.8" "217.0" "204.8" "203.7" "224.3" "573.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.000" "False" "8.230" "3" "3" "3" "3" "763" "85.5" "8.75" "8.48" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "G0 and Early G1" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "3" "0" "0.924" "0.964" "1.053" "1.007" "1.025" "1.059" "1.026" "0.923" "1.007" "526.5" "486.5" "507.6" "554.6" "530.1" "539.8" "557.7" "539.9" "486.1" "530.3" "" "" "" "" "" "" "" "" "" "" "466.9" "403.0" "442.9" "414.8" "442.1" "495.9" "471.4" "446.3" "445.8" "530.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311185762453524816" "False" "High" "IsMasterProtein" "O95905" "Protein ecdysoneless homolog OS=Homo sapiens OX=9606 GN=ECD PE=1 SV=1" "0.000" "False" "8.213" "3" "2" "3" "2" "644" "72.7" "4.87" "10.58" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07093" "11319" "ENSG00000122882" "ECD" "C9JX46; E9PAW8; hsa:11319; O95905" "" "" "0" "0" "1.109" "0.757" "0.958" "0.819" "0.780" "1.046" "0.419" "1.061" "5.078" "58.2" "64.6" "44.1" "55.8" "47.7" "45.4" "60.9" "24.4" "61.8" "295.6" "" "" "" "" "" "" "" "" "" "" "51.6" "53.5" "38.4" "41.7" "39.8" "41.7" "51.4" "20.2" "56.6" "295.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537965283186170392" "False" "High" "IsMasterProtein" "Q9UM13" "Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1" "0.000" "False" "8.210" "11" "2" "2" "2" "185" "21.2" "9.06" "7.51" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf03256" "10393" "ENSG00000164162" "ANAPC10" "D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "0.951" "0.933" "0.885" "0.957" "1.049" "0.870" "0.969" "0.840" "1.270" "472.4" "449.3" "440.9" "418.0" "452.1" "495.4" "411.0" "457.9" "396.6" "600.0" "" "" "" "" "" "" "" "" "" "" "418.9" "372.1" "384.7" "312.6" "377.0" "455.1" "347.4" "378.5" "363.8" "600.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-319216844392798796" "False" "High" "IsMasterProtein" "Q9Y4R8" "Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2" "0.000" "False" "8.208" "4" "4" "4" "4" "837" "91.7" "5.76" "7.28" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10193" "9894" "ENSG00000100726" "TELO2" "D3DU73; hsa:9894; O75168; Q7LDV4; Q9BR21; Q9Y4R8" "" "Fragile X syndrome; Pleural mesothelioma" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7599147423310777868" "False" "High" "IsMasterProtein" "P55199" "RNA polymerase II elongation factor ELL OS=Homo sapiens OX=9606 GN=ELL PE=1 SV=1" "0.000" "False" "8.187" "2" "1" "1" "1" "621" "68.2" "9.33" "5.42" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07303, Pf10390" "8178" "ENSG00000105656" "ELL" "hsa:8178; P55199" "TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; Transcription-Coupled Nucleotide Excision Repair (TC-NER)" "Interactome of polycomb repressive complex 2 (PRC2)" "14" "0" "0.960" "0.710" "0.931" "0.723" "0.963" "0.810" "0.748" "0.838" "2.777" "55.7" "53.5" "39.6" "51.9" "40.3" "53.6" "45.1" "41.7" "46.7" "154.7" "" "" "" "" "" "" "" "" "" "" "49.4" "44.3" "34.5" "38.8" "33.6" "49.3" "38.1" "34.4" "42.8" "154.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7560312729267318795" "False" "High" "IsMasterProtein" "Q5HYI8" "Rab-like protein 3 OS=Homo sapiens OX=9606 GN=RABL3 PE=1 SV=1" "0.000" "False" "8.175" "9" "1" "1" "1" "236" "26.4" "7.11" "5.21" "1" "transport;other biological processes" "other cell component" "other molecular function" "Pf08477" "285282" "ENSG00000144840" "RABL3" "hsa:285282; Q5HYI8; Q8WUD3" "" "" "0" "0" "0.824" "1.111" "1.130" "1.015" "0.966" "1.028" "0.967" "1.036" "1.135" "37.3" "30.7" "41.4" "42.1" "37.8" "36.0" "38.3" "36.0" "38.6" "42.3" "" "" "" "" "" "" "" "" "" "" "33.0" "25.4" "36.1" "31.5" "31.5" "33.1" "32.4" "29.8" "35.4" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5403198551536365946" "False" "High" "IsMasterProtein" "Q14692" "Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens OX=9606 GN=BMS1 PE=1 SV=1" "0.000" "False" "8.169" "1" "1" "1" "1" "1282" "145.7" "6.44" "4.61" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "9790" "ENSG00000165733" "BMS1" "hsa:9790; Q14692; Q5QPT5; Q86XJ9" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.034" "1.098" "1.045" "1.012" "0.944" "0.936" "0.766" "0.915" "0.753" "135.8" "140.4" "149.1" "141.8" "137.4" "128.2" "127.0" "104.0" "124.2" "102.2" "" "" "" "" "" "" "" "" "" "" "120.4" "116.3" "130.1" "106.1" "114.6" "117.8" "107.4" "86.0" "113.9" "102.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6764322891151840328" "False" "High" "IsMasterProtein" "P19484" "Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3" "0.000" "False" "8.152" "5" "3" "3" "2" "476" "52.8" "6.29" "11.00" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7942" "ENSG00000112561" "TFEB" "hsa:7942; P19484; Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8" "" "PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Type 2 papillary renal cell carcinoma; Autophagy in pancreatic ductal adenocarcinoma" "3" "1" "0.912" "0.872" "0.969" "0.836" "0.861" "0.751" "0.710" "0.870" "2.028" "158.3" "144.3" "138.0" "153.4" "132.4" "136.3" "118.9" "112.4" "137.7" "321.1" "" "" "" "" "" "" "" "" "" "" "140.4" "119.5" "120.4" "114.7" "110.4" "125.2" "100.5" "92.9" "126.3" "321.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1178215793923997367" "False" "High" "IsMasterProtein" "Q96DM3" "Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2" "0.000" "False" "8.151" "4" "3" "3" "3" "657" "74.9" "7.83" "9.53" "3" "other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle" "" "Pf07035, Pf21029" "29919" "ENSG00000141452" "RMC1" "Q96DM3; Q9BU17; Q9Y5M0" "" "" "0" "0" "0.964" "0.874" "1.129" "0.985" "0.860" "1.076" "1.020" "0.968" "1.536" "245.2" "236.5" "214.3" "276.9" "241.6" "211.0" "263.9" "250.0" "237.5" "376.7" "" "" "" "" "" "" "" "" "" "" "217.5" "195.9" "186.9" "207.1" "201.4" "193.8" "223.0" "206.7" "217.8" "376.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4075227655953047173" "False" "High" "IsMasterProtein" "Q8IV61" "Ras guanyl-releasing protein 3 OS=Homo sapiens OX=9606 GN=RASGRP3 PE=1 SV=1" "0.000" "False" "8.138" "3" "2" "2" "2" "690" "78.3" "6.80" "6.26" "2" "signal transduction" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00130, Pf00617" "25780" "ENSG00000152689" "RASGRP3" "D6W583; hsa:25780; O94931; Q53SD7; Q8IV61" "RAF/MAP kinase cascade; Activation of RAS in B cells" "B cell receptor signaling pathway; MAPK signaling pathway; Ras signaling" "5" "0" "1.063" "0.913" "1.002" "0.857" "0.981" "0.964" "0.497" "0.768" "5.308" "25.9" "27.6" "23.7" "26.0" "22.2" "25.4" "25.0" "12.9" "19.9" "137.7" "" "" "" "" "" "" "" "" "" "" "23.0" "22.9" "20.7" "19.4" "18.5" "23.4" "21.1" "10.6" "18.3" "137.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6471377721056749589" "False" "High" "IsMasterProtein" "Cont_Q58D62" "Fetuin-B OS=Bos taurus OX=9913 GN=FETUB PE=1 SV=1" "0.000" "True" "8.135" "5" "2" "3" "2" "387" "42.6" "5.77" "6.82" "2" "other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00031" "504615" "ENSBTAG00000017531" "FETUB" "bta:504615; Q58D62" "" "" "0" "0" "1.030" "1.010" "0.798" "1.065" "0.911" "1.082" "1.084" "1.099" "0.563" "850.1" "875.9" "858.7" "678.7" "905.3" "774.4" "920.2" "921.7" "934.0" "478.8" "" "" "" "" "" "" "" "" "" "" "753.8" "725.6" "749.2" "507.6" "754.9" "711.3" "777.7" "761.8" "856.6" "478.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1355108408195266018" "False" "High" "IsMasterProtein" "Q6NZ67" "Mitotic-spindle organizing protein 2B OS=Homo sapiens OX=9606 GN=MZT2B PE=1 SV=1" "0.000" "False" "8.123" "13" "2" "3" "2" "158" "16.2" "10.15" "9.07" "2" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "80097" "ENSG00000152082; ENSG00000292119" "MZT2B" "hsa:80097; Q6NZ67; Q96CG4" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "" "2" "0" "1.087" "1.071" "1.156" "1.099" "1.000" "1.069" "1.035" "1.070" "1.356" "210.1" "228.4" "224.9" "242.8" "230.8" "210.2" "224.5" "217.4" "224.8" "284.9" "" "" "" "" "" "" "" "" "" "" "186.3" "189.2" "196.2" "181.6" "192.4" "193.1" "189.7" "179.7" "206.2" "284.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7322827353079219364" "False" "High" "IsMasterProtein" "Q68DH5" "G-protein coupled receptor-associated protein LMBRD2 OS=Homo sapiens OX=9606 GN=LMBRD2 PE=1 SV=1" "0.000" "False" "8.102" "4" "2" "2" "2" "695" "81.1" "7.50" "4.55" "2" "signal transduction" "plasma membrane;other membranes" "" "Pf04791" "92255" "ENSG00000164187" "LMBRD2" "B3KRB6; hsa:92255; Q68DH5; Q9NTC7" "" "" "0" "0" "1.013" "0.902" "1.157" "1.091" "1.024" "1.151" "1.080" "1.171" "1.063" "113.9" "115.4" "102.8" "131.8" "124.2" "116.6" "131.1" "123.0" "133.3" "121.1" "" "" "" "" "" "" "" "" "" "" "101.0" "95.6" "89.7" "98.6" "103.6" "107.1" "110.8" "101.7" "122.3" "121.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179011071974481602" "False" "High" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "0.000" "False" "8.096" "6" "2" "2" "2" "290" "32.3" "5.14" "7.63" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "0.903" "0.938" "1.056" "0.922" "0.808" "0.863" "0.648" "0.775" "4.188" "149.9" "135.4" "140.7" "158.4" "138.3" "121.2" "129.4" "97.2" "116.3" "627.8" "" "" "" "" "" "" "" "" "" "" "133.0" "112.1" "122.7" "118.5" "115.3" "111.3" "109.4" "80.4" "106.6" "627.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "High" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.000" "False" "8.096" "20" "2" "3" "2" "112" "13.2" "9.99" "6.51" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "mRNA Splicing - Major Pathway" "" "1" "0" "0.981" "0.986" "1.058" "0.949" "1.020" "0.925" "0.991" "0.909" "0.488" "349.6" "343.0" "344.8" "369.9" "331.7" "356.6" "323.3" "346.6" "317.9" "170.7" "" "" "" "" "" "" "" "" "" "" "310.0" "284.2" "300.9" "276.7" "276.6" "327.6" "273.3" "286.5" "291.6" "170.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6627210930524934042" "False" "High" "IsMasterProtein" "Q8TCF1" "AN1-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=ZFAND1 PE=1 SV=1" "0.000" "False" "8.088" "10" "2" "2" "2" "268" "30.8" "7.39" "8.14" "2" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf01428" "79752" "ENSG00000104231" "ZFAND1" "E5RIG0; E5RJ99; hsa:79752; Q658R7; Q6IA32; Q6PGQ6; Q8TCF1; Q9H810" "" "" "0" "0" "0.872" "0.967" "0.692" "0.807" "1.002" "0.943" "0.810" "0.887" "1.138" "123.6" "107.8" "119.5" "85.5" "99.7" "123.8" "116.6" "100.1" "109.6" "140.7" "" "" "" "" "" "" "" "" "" "" "109.6" "89.3" "104.3" "64.0" "83.2" "113.7" "98.5" "82.8" "100.6" "140.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3093573351125982310" "False" "High" "IsMasterProtein" "Q86WJ1" "Chromodomain-helicase-DNA-binding protein 1-like OS=Homo sapiens OX=9606 GN=CHD1L PE=1 SV=3" "0.000" "False" "8.083" "3" "3" "3" "3" "897" "100.9" "6.90" "6.36" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "9557" "ENSG00000131778" "CHD1L" "A5YM64; B4DDE1; B5MDZ7; Q53EZ3; Q5VXX7; Q6DD94; Q6PK83; Q86WJ1; Q86XH3; Q96HF7; Q96SP3; Q9BVJ1; Q9NVV8" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "1q21.1 copy number variation syndrome; Nucleotide excision repair in xeroderma pigmentosum" "4" "0" "1.259" "0.955" "1.180" "1.103" "0.947" "1.010" "0.347" "0.967" "11.604" "130.6" "164.4" "124.7" "154.2" "144.0" "123.7" "131.9" "45.4" "126.3" "1515.3" "" "" "" "" "" "" "" "" "" "" "115.8" "136.1" "108.8" "115.3" "120.1" "113.6" "111.5" "37.5" "115.8" "1515.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1812058185286656363" "False" "High" "IsMasterProtein" "Q9NWZ8" "Gem-associated protein 8 OS=Homo sapiens OX=9606 GN=GEMIN8 PE=1 SV=1" "0.000" "False" "8.077" "11" "3" "3" "3" "242" "28.6" "6.80" "8.78" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15348" "54960" "ENSG00000046647" "GEMIN8" "C4AMC4; hsa:54960; Q2LJ66; Q6ZV27; Q9NWZ8" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "0.903" "0.823" "0.897" "0.676" "0.711" "0.786" "0.637" "0.828" "4.274" "234.9" "212.0" "193.3" "210.7" "158.8" "167.1" "184.6" "149.6" "194.4" "1003.9" "" "" "" "" "" "" "" "" "" "" "208.3" "175.6" "168.7" "157.5" "132.4" "153.5" "156.0" "123.7" "178.3" "1003.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4633912985078584352" "False" "High" "IsMasterProtein" "P07948" "Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3" "0.000" "False" "8.075" "5" "3" "3" "1" "512" "58.5" "7.11" "9.17" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "4067" "ENSG00000254087" "LYN" "A0AVQ5; hsa:4067; P07948" "FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; EPHB-mediated forward signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; CD28 co-stimulation; PECAM1 interactions; CTLA4 inhibitory signaling; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; Cyclin D associated events in G1; Growth hormone receptor signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; Dectin-2 family" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; GDNF signaling" "45" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1936196132069053391" "False" "High" "IsMasterProtein" "Q8WXA9" "Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1" "0.000" "False" "8.066" "5" "2" "2" "2" "508" "59.3" "10.39" "6.88" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "140890" "ENSG00000153914" "SREK1" "A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9" "" "mRNA processing" "1" "0" "1.263" "1.230" "1.325" "1.238" "0.982" "1.310" "0.985" "1.238" "3.937" "130.5" "164.8" "160.5" "173.0" "161.6" "128.1" "171.0" "128.6" "161.5" "513.8" "" "" "" "" "" "" "" "" "" "" "115.7" "136.5" "140.1" "129.3" "134.7" "117.7" "144.5" "106.3" "148.1" "513.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-344337871911847900" "False" "High" "IsMasterProtein" "Q86X53" "Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1" "0.000" "False" "8.041" "4" "1" "1" "1" "443" "49.0" "4.78" "4.96" "1" "" "" "" "" "157697" "ENSG00000104714" "ERICH1" "A8K2J9; hsa:157697; Q86X53; Q9P063" "" "" "0" "0" "1.164" "1.565" "1.007" "1.289" "1.134" "1.206" "1.192" "1.611" "1.365" "116.5" "135.6" "182.3" "117.3" "150.2" "132.1" "140.5" "138.8" "187.6" "159.0" "" "" "" "" "" "" "" "" "" "" "103.3" "112.3" "159.1" "87.7" "125.2" "121.3" "118.8" "114.7" "172.1" "159.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "High" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.000" "False" "8.039" "8" "1" "4" "1" "133" "14.4" "10.17" "9.06" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.056" "0.994" "1.068" "1.106" "1.090" "1.008" "1.118" "1.006" "0.877" "503.5" "531.8" "500.6" "537.6" "556.9" "548.9" "507.7" "562.8" "506.3" "441.7" "" "" "" "" "" "" "" "" "" "" "446.5" "440.5" "436.8" "402.0" "464.3" "504.2" "429.1" "465.2" "464.3" "441.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580971408817382446" "False" "High" "IsMasterProtein" "O75956" "Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1" "0.000" "False" "8.038" "14" "2" "3" "2" "126" "13.1" "9.48" "10.17" "2" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf09806" "10263" "ENSG00000167797" "CDK2AP2" "hsa:10263; O75956" "" "" "0" "0" "0.928" "0.993" "0.841" "1.037" "1.092" "0.860" "0.925" "0.983" "0.845" "483.7" "448.7" "480.5" "406.7" "501.7" "528.4" "416.0" "447.5" "475.5" "408.6" "" "" "" "" "" "" "" "" "" "" "428.9" "371.7" "419.3" "304.1" "418.3" "485.4" "351.6" "369.9" "436.1" "408.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210481861453836415" "False" "High" "IsMasterProtein" "Q9BVM2" "Protein DPCD OS=Homo sapiens OX=9606 GN=DPCD PE=1 SV=2" "0.000" "False" "8.034" "10" "2" "2" "2" "203" "23.2" "9.03" "4.96" "2" "transport;developmental processes;other biological processes" "non-structural extracellular" "" "Pf14913" "25911" "ENSG00000166171" "DPCD" "A8K289; hsa:25911; Q6QNL3; Q8N5R1; Q9BVM2; Q9UFY6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.000" "False" "8.009" "16" "3" "4" "3" "242" "24.1" "7.09" "14.13" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.105" "1.471" "0.867" "1.058" "1.036" "1.154" "1.293" "2.176" "0.520" "298.4" "329.8" "439.0" "258.7" "315.5" "309.1" "344.3" "385.8" "649.2" "155.0" "" "" "" "" "" "" "" "" "" "" "264.6" "273.2" "383.0" "193.5" "263.1" "283.9" "291.0" "318.9" "595.4" "155.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6656067604424276740" "False" "High" "IsMasterProtein" "O95365" "Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1" "0.000" "False" "8.006" "5" "2" "2" "2" "584" "61.4" "5.19" "6.32" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51341" "ENSG00000178951" "ZBTB7A" "D6W619; hsa:51341; O00456; O95365; Q14D41; Q5XG86" "" "IL-18 signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633988099481439098" "False" "High" "IsMasterProtein" "Q9Y5T5" "Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1" "0.000" "False" "8.006" "4" "3" "3" "3" "823" "93.5" "6.93" "9.44" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf00443, Pf02148" "10600" "ENSG00000156256; ENSG00000291527" "USP16" "A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; hsa:10600; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; Q9Y5T5" "Ub-specific processing proteases" "" "1" "0" "1.020" "0.901" "1.084" "0.965" "0.771" "0.883" "0.617" "0.954" "6.882" "137.3" "140.1" "123.7" "148.8" "132.4" "105.9" "121.2" "84.8" "131.0" "944.7" "" "" "" "" "" "" "" "" "" "" "121.7" "116.0" "107.9" "111.3" "110.4" "97.3" "102.4" "70.1" "120.1" "944.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523601130490084284" "False" "High" "IsMasterProtein" "Q9BX63" "Fanconi anemia group J protein OS=Homo sapiens OX=9606 GN=BRIP1 PE=1 SV=2" "0.000" "False" "8.000" "1" "1" "1" "1" "1249" "140.8" "6.92" "6.14" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf13307" "83990" "ENSG00000136492" "BRIP1" "A0A024QZ45; hsa:83990; Q3MJE2; Q8NCI5; Q9BX63" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Cytosolic iron-sulfur cluster assembly" "DNA repair pathways, full network" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "High" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.000" "False" "8.000" "8" "2" "2" "2" "279" "31.7" "7.05" "8.31" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.114" "0.912" "1.014" "1.232" "0.910" "1.077" "1.091" "1.229" "1.970" "66.9" "74.6" "61.0" "67.8" "82.4" "60.9" "72.1" "73.0" "82.3" "131.8" "" "" "" "" "" "" "" "" "" "" "59.4" "61.8" "53.2" "50.7" "68.7" "55.9" "60.9" "60.4" "75.4" "131.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "710012249327667382" "False" "High" "IsMasterProtein" "P48449" "Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1" "0.000" "False" "7.986" "3" "2" "2" "2" "732" "83.3" "6.61" "5.83" "2" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00432" "4047" "ENSG00000160285" "LSS" "B4DJZ9; D3DSN0; E9PEI9; G5E9Q9; P48449; Q8IYL6; Q9UEZ1" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "0.872" "0.877" "0.984" "0.899" "0.899" "0.971" "0.913" "0.953" "1.689" "110.3" "96.2" "96.7" "108.6" "99.2" "99.2" "107.2" "100.8" "105.2" "186.4" "" "" "" "" "" "" "" "" "" "" "97.8" "79.7" "84.4" "81.2" "82.7" "91.1" "90.6" "83.3" "96.4" "186.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472695818303021401" "False" "High" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "0.000" "False" "7.983" "9" "4" "4" "4" "321" "33.8" "10.18" "10.64" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "Rubinstein-Taybi syndrome 1" "3" "0" "1.062" "0.895" "1.042" "1.114" "1.147" "0.931" "0.901" "0.886" "1.201" "181.7" "192.9" "162.7" "189.4" "202.4" "208.4" "169.1" "163.7" "161.0" "218.1" "" "" "" "" "" "" "" "" "" "" "161.1" "159.8" "141.9" "141.6" "168.8" "191.4" "142.9" "135.3" "147.7" "218.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.000" "False" "7.979" "20" "2" "2" "2" "164" "17.8" "5.03" "6.90" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3216869458966544119" "False" "High" "IsMasterProtein" "Q12983" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 OS=Homo sapiens OX=9606 GN=BNIP3 PE=1 SV=4" "0.000" "False" "7.974" "12" "2" "2" "2" "194" "21.5" "6.80" "6.30" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06553" "664" "ENSG00000176171" "BNIP3" "hsa:664; O14620; Q12983; Q96GP0" "" "Photodynamic therapy-induced HIF-1 survival signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766767178054047588" "False" "High" "IsMasterProtein" "Q9BYC9" "Large ribosomal subunit protein bL20m OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "0.000" "False" "7.960" "13" "2" "2" "2" "149" "17.4" "10.86" "6.27" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "1p36 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827521234037792457" "False" "High" "IsMasterProtein" "Q9NUS5" "AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1" "0.000" "False" "7.956" "12" "2" "2" "2" "200" "22.5" "6.87" "6.89" "2" "DNA metabolism;stress response;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf15001" "55317" "ENSG00000125843" "AP5S1" "B3KSD0; D3DVY7; hsa:55317; Q9NUS5" "" "" "0" "0" "1.068" "0.994" "1.055" "1.087" "1.016" "1.009" "0.942" "0.918" "1.303" "131.7" "140.7" "130.9" "139.0" "143.2" "133.8" "132.9" "124.1" "120.9" "171.7" "" "" "" "" "" "" "" "" "" "" "116.8" "116.6" "114.2" "103.9" "119.4" "122.9" "112.3" "102.6" "110.9" "171.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294040977581567700" "False" "High" "IsMasterProtein" "Q9HBF4" "Zinc finger FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFYVE1 PE=1 SV=1" "0.000" "False" "7.951" "3" "2" "2" "2" "777" "87.1" "7.42" "7.49" "2" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "53349" "ENSG00000165861" "ZFYVE1" "hsa:53349; J3KNL9; Q8WYX7; Q96K57; Q9BXP9; Q9HBF4; Q9HCI3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8876035733125179295" "False" "High" "IsMasterProtein" "Q96D71" "RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3" "0.000" "False" "7.927" "2" "2" "2" "2" "796" "86.6" "5.69" "6.99" "2" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "85021" "ENSG00000135597" "REPS1" "B7ZBZ8; B7ZBZ9; B7ZC00; hsa:85021; J3KP76; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q96D71; Q9BXY9" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "1.088" "0.923" "1.150" "1.240" "1.140" "1.158" "0.616" "0.978" "6.971" "47.8" "52.0" "44.1" "55.0" "59.3" "54.5" "55.4" "29.5" "46.8" "333.2" "" "" "" "" "" "" "" "" "" "" "42.4" "43.1" "38.5" "41.1" "49.4" "50.1" "46.8" "24.4" "42.9" "333.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013804065466167884" "False" "High" "IsMasterProtein" "Q3B7T1" "Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1" "0.000" "False" "7.926" "1" "1" "2" "1" "1238" "138.4" "6.33" "6.05" "1" "other biological processes" "nucleus" "" "" "26098" "ENSG00000107938" "EDRF1" "B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569062232649936506" "False" "High" "IsMasterProtein" "Q9NVH2" "Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1" "0.000" "False" "7.925" "2" "2" "2" "2" "962" "106.8" "8.02" "3.66" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "" "25896" "ENSG00000143493" "INTS7" "B4DLZ6; B7WNP6; B7WPB6; hsa:25896; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVH2; Q9NVU5; Q9UFC6; Q9UFM3" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.009" "0.956" "1.219" "1.008" "0.919" "1.068" "0.876" "0.929" "2.712" "156.7" "158.1" "149.9" "191.1" "158.0" "144.0" "167.3" "137.3" "145.5" "425.0" "" "" "" "" "" "" "" "" "" "" "139.0" "130.9" "130.8" "142.9" "131.7" "132.3" "141.4" "113.4" "133.5" "425.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431440183355440202" "False" "High" "IsMasterProtein" "Q9ULL5" "Proline-rich protein 12 OS=Homo sapiens OX=9606 GN=PRR12 PE=1 SV=3" "0.000" "False" "7.925" "1" "2" "2" "2" "2036" "210.9" "7.87" "7.07" "2" "" "nucleus;other cell component" "" "Pf13926" "57479" "ENSG00000126464" "PRR12" "E9PB06; hsa:57479; Q8N4J6; Q9ULL5" "" "" "0" "0" "1.067" "0.907" "0.943" "0.975" "1.047" "1.000" "1.059" "0.940" "1.203" "212.0" "226.3" "192.3" "200.0" "206.7" "221.9" "212.1" "224.5" "199.4" "255.1" "" "" "" "" "" "" "" "" "" "" "188.0" "187.5" "167.8" "149.6" "172.3" "203.8" "179.2" "185.5" "182.9" "255.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5860754846925802701" "False" "High" "IsMasterProtein" "O95400" "CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1" "0.000" "False" "7.913" "4" "1" "1" "1" "341" "37.6" "4.61" "3.86" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02213" "10421" "ENSG00000169217" "CD2BP2" "B2RDX2; hsa:10421; O95400; Q9ULP2" "" "mRNA processing; Ciliary landscape" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "High" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.000" "False" "7.898" "3" "3" "4" "2" "876" "98.4" "9.32" "11.80" "3" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "0.958" "1.009" "0.982" "0.941" "0.941" "0.966" "0.983" "1.033" "1.438" "206.2" "197.5" "208.1" "202.5" "194.1" "194.0" "199.3" "202.8" "213.0" "296.6" "" "" "" "" "" "" "" "" "" "" "182.9" "163.6" "181.5" "151.4" "161.9" "178.2" "168.4" "167.6" "195.4" "296.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1299215584084045003" "False" "High" "IsMasterProtein" "Q9BRQ3" "Uridine diphosphate glucose pyrophosphatase NUDT22 OS=Homo sapiens OX=9606 GN=NUDT22 PE=1 SV=3" "0.000" "False" "7.878" "10" "2" "2" "2" "303" "32.6" "5.11" "6.62" "2" "" "nucleus" "other molecular function" "" "84304" "ENSG00000149761" "NUDT22" "C9JY06; hsa:84304; Q71RD5; Q9BRQ3" "" "" "0" "0" "1.270" "1.218" "1.538" "1.335" "1.117" "1.427" "1.233" "1.309" "1.686" "22.3" "28.3" "27.2" "34.3" "29.8" "24.9" "31.8" "27.5" "29.2" "37.6" "" "" "" "" "" "" "" "" "" "" "19.8" "23.4" "23.7" "25.6" "24.8" "22.9" "26.9" "22.7" "26.8" "37.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7216673517695953879" "False" "High" "IsMasterProtein" "Q8TDZ2" "[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2" "0.000" "False" "7.871" "3" "3" "3" "3" "1067" "117.8" "6.40" "8.62" "3" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "64780" "ENSG00000135596" "MICAL1" "B7Z3R5; E1P5F0; Q7Z633; Q8IVS9; Q8TDZ2; Q96G47; Q9H6X6; Q9H7I0; Q9HAA1; Q9UFF7" "Factors involved in megakaryocyte development and platelet production" "" "1" "0" "1.143" "1.040" "1.077" "0.969" "0.858" "1.069" "0.536" "1.002" "9.828" "83.5" "95.5" "86.9" "90.0" "80.9" "71.7" "89.3" "44.8" "83.7" "821.0" "" "" "" "" "" "" "" "" "" "" "74.1" "79.1" "75.8" "67.3" "67.5" "65.8" "75.4" "37.0" "76.7" "821.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1333795596038477477" "False" "High" "IsMasterProtein" "P62877" "E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1" "0.000" "False" "7.867" "13" "2" "4" "2" "108" "12.3" "6.96" "14.61" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9978" "ENSG00000100387" "RBX1" "B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254" "Potential therapeutics for SARS; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; KEAP1-NFE2L2 pathway; Negative regulation of NOTCH4 signaling; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; Dual hijack model of Vif in HIV infection; TGF-beta signaling pathway; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome" "48" "0" "1.048" "1.147" "0.966" "0.999" "1.038" "1.175" "1.208" "1.391" "0.590" "297.2" "311.4" "341.0" "287.1" "296.9" "308.6" "349.1" "358.9" "413.2" "175.3" "" "" "" "" "" "" "" "" "" "" "263.5" "257.9" "297.5" "214.7" "247.6" "283.5" "295.0" "296.6" "379.0" "175.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8721939623497573862" "False" "High" "IsMasterProtein" "Q86YV5" "Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4" "0.000" "False" "7.866" "1" "1" "1" "1" "1406" "149.5" "7.20" "4.66" "1" "other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "157285" "ENSG00000275342" "PRAG1" "Q86YV5; Q8N3N5" "RND2 GTPase cycle" "" "1" "0" "0.887" "0.964" "0.712" "0.908" "0.860" "0.861" "0.775" "0.749" "3.344" "26.8" "23.7" "25.8" "19.1" "24.3" "23.0" "23.0" "20.7" "20.1" "89.5" "" "" "" "" "" "" "" "" "" "" "23.7" "19.7" "22.5" "14.3" "20.3" "21.1" "19.5" "17.1" "18.4" "89.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-155447427223618220" "False" "High" "IsMasterProtein" "A6NFY7" "Succinate dehydrogenase assembly factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF1 PE=1 SV=1" "0.000" "False" "7.860" "20" "2" "3" "2" "115" "12.8" "11.39" "10.48" "2" "cell organization and biogenesis" "mitochondrion;nucleus" "" "Pf05347" "644096" "ENSG00000205138" "SDHAF1" "A6NFY7; B2RPM7; hsa:644096" "" "Mitochondrial complex II assembly" "1" "0" "1.116" "1.018" "1.020" "1.039" "1.017" "0.954" "1.003" "0.834" "0.780" "171.9" "191.9" "174.9" "175.3" "178.7" "174.8" "164.1" "172.4" "143.4" "134.0" "" "" "" "" "" "" "" "" "" "" "152.5" "158.9" "152.6" "131.1" "149.0" "160.6" "138.7" "142.5" "131.5" "134.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5203794321803300352" "False" "High" "IsMasterProtein" "Q9UKI3" "Pre-B lymphocyte protein 3 OS=Homo sapiens OX=9606 GN=VPREB3 PE=1 SV=1" "0.000" "False" "7.854" "11" "1" "2" "1" "123" "13.7" "5.36" "8.29" "1" "other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf07686" "29802" "ENSG00000128218" "VPREB3" "B2R587; hsa:29802; Q9UKI3" "Cell surface interactions at the vascular wall" "" "1" "0" "1.005" "0.953" "0.975" "1.180" "1.044" "1.113" "0.962" "1.200" "1.168" "167.1" "167.9" "159.3" "162.9" "197.1" "174.4" "185.9" "160.8" "200.5" "195.1" "" "" "" "" "" "" "" "" "" "" "148.2" "139.1" "139.0" "121.9" "164.4" "160.2" "157.1" "132.9" "183.9" "195.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8527831482180649662" "False" "High" "IsMasterProtein" "Q8NCE2" "Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2" "0.000" "False" "7.824" "3" "2" "2" "2" "650" "72.2" "6.24" "5.96" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "" "64419" "ENSG00000163719" "MTMR14" "hsa:64419; Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8NCE2; Q8TCM7; Q9H6C0" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8492559823843858039" "False" "High" "IsMasterProtein" "Q6ZW49" "PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2" "0.000" "False" "7.813" "1" "1" "1" "1" "1069" "121.3" "6.70" "5.59" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf00533, Pf12738, Pf16589" "22976" "ENSG00000157212" "PAXIP1" "hsa:22976; O15404; Q6N099; Q6ZW49; Q6ZWH9; Q7Z315; Q86UN0; Q8N4P9; Q96HP2" "Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of WDR5-containing histone-modifying complexes" "16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Kleefstra syndrome" "6" "0" "1.224" "1.051" "0.913" "0.881" "0.985" "1.175" "1.065" "1.018" "1.631" "68.9" "84.4" "72.4" "62.9" "60.7" "67.9" "81.0" "73.4" "70.2" "112.4" "" "" "" "" "" "" "" "" "" "" "61.1" "69.9" "63.2" "47.0" "50.6" "62.4" "68.4" "60.7" "64.3" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "High" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.000" "False" "7.768" "3" "2" "2" "2" "540" "59.7" "7.66" "5.93" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "0.812" "0.704" "0.766" "0.565" "0.251" "0.460" "0.503" "0.652" "2.295" "104.7" "85.1" "73.7" "80.2" "59.2" "26.3" "48.1" "52.6" "68.3" "240.4" "" "" "" "" "" "" "" "" "" "" "92.9" "70.5" "64.3" "60.0" "49.4" "24.1" "40.7" "43.5" "62.7" "240.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3850938661228975130" "False" "High" "IsMasterProtein" "Q9NQ55" "Suppressor of SWI4 1 homolog OS=Homo sapiens OX=9606 GN=PPAN PE=1 SV=1" "0.000" "False" "7.767" "2" "1" "2" "1" "473" "53.2" "10.13" "6.13" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04427" "56342; 692312" "ENSG00000130810" "PPAN" "C9J3F9; hsa:56342; hsa:692312; Q9BW97; Q9H170; Q9NQ55" "" "" "0" "0" "1.109" "0.883" "0.822" "0.968" "0.973" "0.931" "0.854" "0.821" "0.606" "33.2" "36.8" "29.3" "27.3" "32.1" "32.3" "30.9" "28.4" "27.3" "20.1" "" "" "" "" "" "" "" "" "" "" "29.5" "30.5" "25.6" "20.4" "26.8" "29.7" "26.1" "23.4" "25.0" "20.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295020939105715533" "False" "High" "IsMasterProtein" "Q9NRS6" "Sorting nexin-15 OS=Homo sapiens OX=9606 GN=SNX15 PE=1 SV=1" "0.000" "False" "7.755" "8" "3" "3" "2" "342" "38.3" "5.19" "10.48" "3" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00787, Pf04212" "29907" "ENSG00000110025" "SNX15" "E5KQS6; hsa:29907; Q9NRS5; Q9NRS6" "" "" "0" "0" "0.928" "0.861" "0.917" "0.984" "0.908" "1.032" "0.713" "0.791" "2.171" "89.5" "83.1" "77.0" "82.0" "88.1" "81.2" "92.4" "63.8" "70.8" "194.3" "" "" "" "" "" "" "" "" "" "" "79.4" "68.8" "67.2" "61.3" "73.4" "74.6" "78.1" "52.7" "64.9" "194.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8727669707947595879" "False" "High" "IsMasterProtein" "Q15058" "Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1" "0.000" "False" "7.755" "1" "1" "1" "1" "1648" "186.4" "7.91" "4.01" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf16183" "9928" "ENSG00000118193" "KIF14" "hsa:9928; Q14CI8; Q15058; Q4G0A5; Q5T1W3" "RND2 GTPase cycle; RND1 GTPase cycle; RHO GTPases activate CIT" "" "3" "0" "1.141" "1.103" "1.044" "0.672" "0.841" "1.007" "0.775" "1.062" "1.326" "37.5" "42.8" "41.4" "39.2" "25.2" "31.6" "37.8" "29.1" "39.8" "49.7" "" "" "" "" "" "" "" "" "" "" "33.3" "35.5" "36.1" "29.3" "21.0" "29.0" "31.9" "24.0" "36.5" "49.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1908933075179858623" "False" "High" "IsMasterProtein" "Cont_A2I7N3" "Serpin A3-7 OS=Bos taurus OX=9913 GN=SERPINA3-7 PE=3 SV=1" "0.000" "True" "7.737" "6" "3" "3" "3" "417" "46.9" "6.34" "10.57" "3" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "" "" "SERPINA3-7" "A2I7N3" "" "" "0" "0" "1.122" "0.858" "0.724" "0.825" "0.470" "0.597" "0.897" "0.841" "0.446" "457.6" "513.5" "392.7" "331.2" "377.7" "215.2" "273.3" "410.3" "384.7" "204.3" "" "" "" "" "" "" "" "" "" "" "405.8" "425.4" "342.7" "247.7" "315.0" "197.7" "230.9" "339.1" "352.8" "204.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5475559016249233817" "False" "High" "IsMasterProtein" "Q9NVT9" "Armadillo repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=ARMC1 PE=1 SV=1" "0.000" "False" "7.733" "4" "1" "1" "1" "282" "31.3" "5.74" "5.01" "1" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00514" "55156" "ENSG00000104442" "ARMC1" "B4E2W7; hsa:55156; Q9H018; Q9H820; Q9NVT9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621836974049986451" "False" "High" "IsMasterProtein" "Q9Y3E7" "Charged multivesicular body protein 3 OS=Homo sapiens OX=9606 GN=CHMP3 PE=1 SV=3" "0.000" "False" "7.729" "14" "4" "4" "4" "222" "25.1" "5.12" "12.29" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "100526767; 51652" "ENSG00000115561" "CHMP3" "A8K3W0; B4DG34; B8ZZM0; B8ZZX5; hsa:100526767; hsa:51652; Q3ZTS9; Q53S71; Q53SU5; Q9NZ51; Q9Y3E7" "Macroautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "0.913" "0.933" "0.870" "0.804" "0.829" "0.840" "0.827" "0.941" "0.689" "1226.1" "1118.9" "1144.3" "1066.3" "985.7" "1016.7" "1029.6" "1014.6" "1154.2" "845.3" "" "" "" "" "" "" "" "" "" "" "1087.3" "926.8" "998.4" "797.4" "821.9" "933.9" "870.1" "838.6" "1058.6" "845.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "241048540786940869" "False" "High" "IsMasterProtein" "Q9HCH0" "Nck-associated protein 5-like OS=Homo sapiens OX=9606 GN=NCKAP5L PE=1 SV=4" "0.000" "False" "7.722" "1" "2" "2" "2" "1334" "139.4" "8.06" "6.36" "2" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf15246" "57701" "ENSG00000167566" "NCKAP5L" "hsa:57701; Q2TB26; Q71RH1; Q8N4W1; Q96HX2; Q9HCH0" "" "" "0" "0" "0.978" "0.939" "0.941" "0.982" "0.932" "0.995" "0.928" "1.009" "1.423" "208.3" "203.7" "195.5" "196.0" "204.6" "194.1" "207.3" "193.2" "210.2" "296.4" "" "" "" "" "" "" "" "" "" "" "184.7" "168.7" "170.6" "146.6" "170.6" "178.3" "175.2" "159.7" "192.8" "296.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4219783111601557579" "False" "High" "IsMasterProtein" "Q13216" "DNA excision repair protein ERCC-8 OS=Homo sapiens OX=9606 GN=ERCC8 PE=1 SV=1" "0.000" "False" "7.720" "7" "3" "3" "3" "396" "44.0" "6.35" "9.14" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "1161" "ENSG00000049167" "ERCC8" "B2RB64; hsa:1161; Q13216; Q6FHX5; Q96GB9" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 10q11.21q11.23 copy number variation syndrome" "9" "0" "0.953" "0.865" "0.964" "1.027" "1.004" "0.952" "0.971" "0.978" "0.586" "147.9" "141.0" "127.9" "142.6" "151.9" "148.5" "140.9" "143.7" "144.7" "86.7" "" "" "" "" "" "" "" "" "" "" "131.2" "116.8" "111.6" "106.7" "126.6" "136.4" "119.1" "118.8" "132.7" "86.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6507814139192882220" "False" "High" "IsMasterProtein" "Q9H6K1" "Protein ILRUN OS=Homo sapiens OX=9606 GN=ILRUN PE=1 SV=2" "0.000" "False" "7.716" "8" "1" "1" "1" "298" "32.9" "4.58" "4.38" "1" "other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf14555, Pf16158" "64771" "ENSG00000196821" "ILRUN" "B2R8K7; hsa:64771; Q5VV77; Q96MG5; Q9BUR9; Q9H6K1" "" "" "0" "0" "1.120" "0.843" "0.948" "0.800" "1.153" "1.259" "1.013" "0.877" "0.863" "31.9" "35.8" "26.9" "30.3" "25.5" "36.8" "40.2" "32.3" "28.0" "27.6" "" "" "" "" "" "" "" "" "" "" "28.3" "29.6" "23.5" "22.6" "21.3" "33.8" "34.0" "26.7" "25.7" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158291117488105620" "False" "High" "IsMasterProtein" "Q19AV6" "Zinc finger SWIM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ZSWIM7 PE=1 SV=1" "0.000" "False" "7.712" "26" "3" "4" "3" "140" "15.4" "7.15" "10.32" "3" "DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04434" "125150" "ENSG00000214941" "ZSWIM7" "hsa:125150; Q19AV6" "" "" "0" "0" "1.447" "1.257" "1.232" "0.843" "1.374" "1.568" "1.200" "1.023" "0.540" "18.9" "27.4" "23.8" "23.3" "16.0" "26.0" "29.7" "22.7" "19.4" "10.2" "" "" "" "" "" "" "" "" "" "" "16.8" "22.7" "20.8" "17.4" "13.3" "23.9" "25.1" "18.8" "17.8" "10.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731274812714259147" "False" "High" "IsMasterProtein" "Q9NYJ8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Homo sapiens OX=9606 GN=TAB2 PE=1 SV=1" "0.000" "False" "7.703" "3" "2" "2" "2" "693" "76.4" "8.54" "5.19" "2" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02845" "23118" "ENSG00000055208" "TAB2" "B2RCC4; E1P5A0; hsa:23118; O94838; Q6I9W8; Q76N06; Q9NYJ8; Q9UFP7" "Downstream TCR signaling; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Nuclear signaling by ERBB4; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; TLR4 signaling and tolerance; Exercise-induced circadian regulation; miRNA role in immune response in sepsis; Measles virus infection; Hepatitis B infection; Toll-like receptor signaling pathway" "27" "0" "0.974" "0.839" "0.911" "0.951" "0.901" "1.027" "0.989" "1.027" "1.403" "354.3" "345.1" "297.3" "322.7" "336.8" "319.3" "363.8" "350.3" "363.8" "497.0" "" "" "" "" "" "" "" "" "" "" "314.2" "285.8" "259.4" "241.4" "280.9" "293.3" "307.5" "289.5" "333.7" "497.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109513475254745228" "False" "High" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "0.000" "False" "7.703" "5" "4" "5" "3" "711" "82.2" "7.61" "12.83" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9028825818345530826" "False" "High" "IsMasterProtein" "Q9UNZ5" "Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1" "0.000" "False" "7.697" "26" "3" "3" "3" "99" "10.6" "11.55" "5.18" "3" "" "" "" "Pf09495" "28974" "ENSG00000104979" "C19orf53" "B2R4J9; hsa:28974; Q9UNZ5" "" "" "0" "0" "0.893" "0.848" "0.916" "0.674" "0.499" "0.390" "0.658" "0.680" "0.385" "142.5" "127.3" "120.9" "130.6" "96.1" "71.1" "55.5" "93.8" "96.9" "54.8" "" "" "" "" "" "" "" "" "" "" "126.4" "105.5" "105.5" "97.7" "80.1" "65.3" "46.9" "77.5" "88.8" "54.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5057410005729893010" "False" "High" "IsMasterProtein" "Q7Z4Q2" "HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2" "0.000" "False" "7.693" "5" "3" "3" "3" "680" "74.5" "5.11" "5.35" "3" "transport;other biological processes" "" "other molecular function" "Pf13513" "55027" "ENSG00000155393" "HEATR3" "A8K1N4; hsa:55027; Q7Z4Q2; Q8N525; Q8WV56; Q96CC9; Q9NWN7" "" "" "0" "0" "1.271" "1.565" "0.937" "0.960" "0.867" "1.160" "0.861" "0.982" "2.024" "108.9" "138.5" "170.5" "102.1" "104.5" "94.4" "126.4" "93.8" "106.9" "220.5" "" "" "" "" "" "" "" "" "" "" "96.6" "114.7" "148.8" "76.4" "87.2" "86.7" "106.8" "77.6" "98.1" "220.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3441186793177341923" "False" "High" "IsMasterProtein" "Q969M3" "Protein YIPF5 OS=Homo sapiens OX=9606 GN=YIPF5 PE=1 SV=1" "0.000" "False" "7.693" "5" "1" "1" "1" "257" "28.0" "4.36" "3.82" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "" "Pf04893" "81555" "ENSG00000145817" "YIPF5" "D3DQF5; hsa:81555; Q4VSN6; Q53EX4; Q8NHE5; Q969M3; Q9H338; Q9H3U4" "" "" "0" "0" "1.016" "1.060" "0.978" "1.048" "1.214" "0.928" "1.022" "0.971" "0.562" "142.0" "144.2" "150.6" "138.9" "148.9" "172.4" "131.8" "145.1" "137.8" "79.8" "" "" "" "" "" "" "" "" "" "" "125.9" "119.5" "131.4" "103.9" "124.1" "158.4" "111.4" "119.9" "126.4" "79.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669884478691125184" "False" "High" "IsMasterProtein" "Q8N8J7" "Uncharacterized protein FAM241A OS=Homo sapiens OX=9606 GN=FAM241A PE=1 SV=2" "0.000" "False" "7.692" "13" "1" "1" "1" "132" "14.6" "4.70" "5.50" "1" "" "other membranes;ER/Golgi;other cell component" "" "Pf15378" "132720" "ENSG00000174749" "FAM241A" "Q49A91; Q4W5C7; Q8N8J7; Q8TBF9" "" "" "0" "0" "1.005" "1.054" "1.210" "1.144" "0.911" "1.145" "0.919" "1.063" "0.727" "81.7" "82.1" "86.1" "98.9" "93.5" "74.4" "93.6" "75.1" "86.9" "59.5" "" "" "" "" "" "" "" "" "" "" "72.5" "68.0" "75.2" "74.0" "78.0" "68.4" "79.1" "62.1" "79.7" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265471816786777464" "False" "High" "IsMasterProtein" "Q9Y657" "Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3" "0.000" "False" "7.687" "11" "2" "3" "2" "262" "29.6" "6.96" "6.18" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02513" "10927" "ENSG00000106723" "SPIN1" "A8K0X6; B3KRQ4; hsa:10927; Q7KZJ8; Q9GZT2; Q9H0N7; Q9Y657" "" "" "0" "0" "0.794" "0.991" "0.916" "1.075" "1.027" "0.950" "1.056" "0.740" "0.546" "61.1" "48.5" "60.6" "56.0" "65.7" "62.8" "58.1" "64.6" "45.3" "33.3" "" "" "" "" "" "" "" "" "" "" "54.2" "40.2" "52.9" "41.9" "54.8" "57.7" "49.1" "53.4" "41.5" "33.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5086527343524186673" "False" "High" "IsMasterProtein" "Q9UH36" "SRR1-like protein OS=Homo sapiens OX=9606 GN=SRRD PE=1 SV=1" "0.000" "False" "7.686" "9" "3" "3" "3" "339" "38.5" "5.41" "9.32" "3" "other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf07985" "402055" "ENSG00000100104" "SRRD" "hsa:402055; Q6NXP8; Q9UH36" "" "" "0" "0" "1.015" "0.983" "0.907" "0.949" "0.979" "0.857" "1.004" "0.995" "0.833" "345.1" "350.1" "339.1" "312.9" "327.4" "337.7" "295.6" "346.4" "343.2" "287.5" "" "" "" "" "" "" "" "" "" "" "306.0" "290.0" "295.9" "234.0" "273.0" "310.2" "249.9" "286.3" "314.8" "287.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3237045866174408172" "False" "High" "IsMasterProtein" "Cont_P20930" "Filaggrin OS=Homo sapiens OX=9606 GN=FLG PE=1 SV=3" "0.000" "True" "7.686" "2" "2" "2" "2" "4061" "434.9" "9.25" "2.63" "2" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf01023, Pf03516" "2312" "ENSG00000143631" "FLG" "hsa:2312; P20930; Q01720; Q5T583; Q9UC71" "Formation of the cornified envelope" "" "1" "0" "0.741" "0.874" "1.109" "1.197" "0.880" "0.968" "1.099" "0.965" "0.687" "26.0" "19.2" "22.7" "28.8" "31.1" "22.9" "25.1" "28.5" "25.1" "17.8" "" "" "" "" "" "" "" "" "" "" "23.0" "15.9" "19.8" "21.5" "25.9" "21.0" "21.2" "23.6" "23.0" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "High" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.000" "False" "7.681" "5" "2" "2" "2" "356" "40.0" "7.05" "6.17" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.006" "0.803" "0.914" "1.145" "1.203" "1.097" "0.809" "1.250" "5.574" "27.9" "28.1" "22.4" "25.5" "32.0" "33.6" "30.6" "22.6" "34.9" "155.6" "" "" "" "" "" "" "" "" "" "" "24.8" "23.3" "19.6" "19.1" "26.7" "30.8" "25.9" "18.7" "32.0" "155.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8361684917289872737" "False" "High" "IsMasterProtein" "Q9BSW2" "EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2" "0.000" "False" "7.679" "2" "2" "2" "2" "731" "83.1" "5.24" "6.72" "2" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071, Pf13499" "84766" "ENSG00000130038" "CRACR2A" "B4E1X0; B9EK63; hsa:84766; Q9BSW2" "Neutrophil degranulation" "Vitamin D receptor pathway" "2" "0" "1.000" "0.932" "0.933" "0.939" "1.076" "1.003" "0.952" "1.064" "1.816" "347.4" "347.4" "323.9" "324.3" "326.3" "373.7" "348.6" "330.8" "369.5" "630.9" "" "" "" "" "" "" "" "" "" "" "308.1" "287.8" "282.6" "242.5" "272.1" "343.3" "294.6" "273.5" "338.9" "630.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1355905293603533123" "False" "High" "IsMasterProtein" "Q9Y2Z2" "Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2" "0.000" "False" "7.678" "3" "2" "2" "2" "717" "79.9" "8.31" "7.07" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01134, Pf13932, Pf21680" "25821" "ENSG00000135297" "MTO1" "B3KQB5; hsa:25821; Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; Q9Y2Z2" "tRNA modification in the mitochondrion" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711402174933544761" "False" "High" "IsMasterProtein" "Q8NG31" "Kinetochore scaffold 1 OS=Homo sapiens OX=9606 GN=KNL1 PE=1 SV=3" "0.000" "False" "7.664" "1" "3" "3" "3" "2342" "265.2" "5.47" "8.11" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf18210, Pf19221" "57082" "ENSG00000137812" "KNL1" "hsa:57082; Q8NG31; Q8NHE1; Q8WXA6; Q9HCK2; Q9NR92" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "" "7" "0" "0.865" "0.745" "0.865" "0.720" "0.950" "0.682" "0.779" "0.637" "0.831" "593.7" "513.8" "442.5" "513.6" "427.7" "564.0" "404.9" "462.4" "378.0" "493.1" "" "" "" "" "" "" "" "" "" "" "526.5" "425.6" "386.1" "384.1" "356.7" "518.1" "342.2" "382.2" "346.7" "493.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2098721597077854322" "False" "High" "IsMasterProtein" "Q9NTJ4" "Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1" "0.000" "False" "7.663" "2" "2" "2" "2" "1040" "115.8" "6.57" "6.26" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf17677" "4123" "ENSG00000140400" "MAN2C1" "H3BMX2; H3BQY8; H3BUT6; hsa:4123; Q13358; Q68EM8; Q9NTJ4; Q9UL64" "Lysosomal oligosaccharide catabolism" "" "1" "0" "1.015" "0.809" "1.068" "0.887" "0.946" "0.975" "0.918" "0.790" "0.922" "209.6" "212.7" "169.6" "223.9" "185.9" "198.2" "204.4" "192.3" "165.6" "193.3" "" "" "" "" "" "" "" "" "" "" "185.8" "176.2" "148.0" "167.4" "155.0" "182.1" "172.7" "159.0" "151.9" "193.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410624310622087342" "False" "High" "IsMasterProtein" "Q13227" "G protein pathway suppressor 2 OS=Homo sapiens OX=9606 GN=GPS2 PE=1 SV=3" "0.000" "False" "7.661" "5" "2" "3" "2" "327" "36.7" "9.52" "12.94" "2" "stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15991" "2874" "ENSG00000132522; ENSG00000288325" "GPS2" "B4DXA1; hsa:2874; Q13227; Q6FHM8" "HDACs deacetylate histones; PPARA activates gene expression; HCMV Early Events; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "Rett syndrome" "7" "0" "0.985" "0.976" "0.896" "0.917" "0.924" "0.867" "0.755" "0.881" "1.042" "302.4" "297.9" "295.0" "270.9" "277.3" "279.4" "262.0" "228.2" "266.2" "315.0" "" "" "" "" "" "" "" "" "" "" "268.1" "246.8" "257.4" "202.6" "231.3" "256.7" "221.4" "188.7" "244.2" "315.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6110618285749793440" "False" "High" "IsMasterProtein" "Q96PV7" "Protein FAM193B OS=Homo sapiens OX=9606 GN=FAM193B PE=1 SV=3" "0.000" "False" "7.652" "1" "1" "1" "1" "902" "96.5" "7.90" "4.21" "1" "" "nucleus;other cell component" "" "Pf15914" "" "ENSG00000146067" "FAM193B" "E9PET5; Q96PV7; Q9NW00" "" "5q35 copy number variation" "1" "0" "1.454" "1.016" "1.472" "1.367" "1.099" "1.213" "1.145" "1.936" "1.016" "60.8" "88.3" "61.7" "89.4" "83.1" "66.8" "73.7" "69.6" "117.6" "61.7" "" "" "" "" "" "" "" "" "" "" "53.9" "73.2" "53.9" "66.9" "69.3" "61.4" "62.3" "57.5" "107.8" "61.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4589433783542351991" "False" "High" "IsMasterProtein" "Q9NVU0" "DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1" "0.000" "False" "7.630" "3" "2" "2" "2" "708" "79.8" "6.47" "7.01" "2" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "" "Pf04801, Pf19725" "55718" "ENSG00000058600; ENSG00000284282" "POLR3E" "B4DL24; B4DUP6; H3BT11; hsa:55718; Q9BWF7; Q9H8W8; Q9H907; Q9NVU0; Q9P276" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8804712893716096184" "False" "High" "IsMasterProtein" "Q96S66" "Chloride channel CLIC-like protein 1 OS=Homo sapiens OX=9606 GN=CLCC1 PE=1 SV=1" "0.000" "False" "7.627" "4" "2" "3" "2" "551" "62.0" "5.55" "8.24" "2" "transport" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf05934" "23155" "ENSG00000121940" "CLCC1" "hsa:23155; O94861; Q8WYP8; Q8WYP9; Q96S66; Q9BU25" "" "" "0" "0" "1.063" "0.903" "1.134" "0.932" "0.928" "1.295" "1.002" "0.898" "0.778" "120.4" "128.0" "108.8" "136.5" "112.3" "111.8" "156.0" "120.7" "108.2" "93.7" "" "" "" "" "" "" "" "" "" "" "106.8" "106.0" "94.9" "102.1" "93.6" "102.7" "131.8" "99.7" "99.2" "93.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3978258356038081382" "False" "High" "IsMasterProtein" "Q13416" "Origin recognition complex subunit 2 OS=Homo sapiens OX=9606 GN=ORC2 PE=1 SV=2" "0.000" "False" "7.615" "5" "3" "3" "3" "577" "65.9" "6.51" "9.85" "3" "DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf04084" "4999" "ENSG00000115942" "ORC2" "hsa:4999; Q13204; Q13416; Q53TX5" "Activation of ATR in response to replication stress; Orc1 removal from chromatin; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "0.967" "1.048" "1.044" "1.005" "0.992" "0.923" "0.864" "0.954" "2.609" "125.9" "121.8" "132.0" "131.5" "126.6" "124.9" "116.3" "108.8" "120.2" "328.6" "" "" "" "" "" "" "" "" "" "" "111.7" "100.9" "115.1" "98.3" "105.6" "114.7" "98.3" "90.0" "110.2" "328.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5509725452834477893" "False" "High" "IsMasterProtein" "Q96DU3" "SLAM family member 6 OS=Homo sapiens OX=9606 GN=SLAMF6 PE=1 SV=3" "0.000" "False" "7.615" "8" "3" "4" "3" "332" "37.3" "6.79" "9.55" "3" "stress response;other biological processes" "plasma membrane;other membranes" "" "Pf07686" "114836" "ENSG00000162739" "SLAMF6" "A6NMW2; B2R8X8; hsa:114836; Q14CF0; Q5TAS4; Q5TAS6; Q5TAT3; Q96DU3; Q96DV0" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "1.054" "0.917" "0.964" "0.837" "0.891" "0.816" "0.861" "1.022" "0.828" "96.8" "102.0" "88.7" "93.3" "81.0" "86.3" "78.9" "83.3" "98.9" "80.1" "" "" "" "" "" "" "" "" "" "" "85.8" "84.5" "77.4" "69.8" "67.6" "79.2" "66.7" "68.8" "90.7" "80.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864726906583361359" "False" "High" "IsMasterProtein" "Q7L3T8" "Probable proline--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=PARS2 PE=1 SV=1" "0.000" "False" "7.602" "5" "1" "1" "1" "475" "53.2" "8.10" "6.38" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf03129" "25973" "ENSG00000162396" "PARS2" "A8K0W4; hsa:25973; Q7L3T8; Q9H6S5; Q9UFT1" "Mitochondrial tRNA aminoacylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.000" "False" "7.600" "14" "2" "3" "2" "167" "18.8" "5.12" "11.82" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "" "2" "0" "1.131" "1.043" "1.088" "1.103" "1.135" "1.055" "0.966" "1.108" "1.496" "347.4" "392.8" "362.5" "378.0" "383.3" "394.4" "366.4" "335.6" "385.0" "519.8" "" "" "" "" "" "" "" "" "" "" "308.1" "325.4" "316.3" "282.7" "319.6" "362.3" "309.7" "277.4" "353.1" "519.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2559910864719892942" "False" "High" "IsMasterProtein" "Q9NU19" "TBC1 domain family member 22B OS=Homo sapiens OX=9606 GN=TBC1D22B PE=1 SV=3" "0.000" "False" "7.572" "5" "3" "3" "2" "505" "59.0" "7.39" "8.85" "3" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "55633" "ENSG00000065491" "TBC1D22B" "A8KA28; hsa:55633; Q32MQ8; Q5VUK9; Q6P4C3; Q7Z6P7; Q9BPV6; Q9BUT5; Q9NU19; Q9NXB6" "" "" "0" "0" "1.134" "0.955" "1.084" "0.987" "0.939" "1.110" "0.941" "0.987" "0.904" "138.0" "156.6" "131.8" "149.6" "136.3" "129.6" "153.2" "130.0" "136.2" "124.8" "" "" "" "" "" "" "" "" "" "" "122.4" "129.7" "115.0" "111.9" "113.6" "119.0" "129.5" "107.4" "124.9" "124.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832691486978412117" "False" "High" "IsMasterProtein" "Q5BJH7" "Protein YIF1B OS=Homo sapiens OX=9606 GN=YIF1B PE=1 SV=1" "0.000" "False" "7.569" "8" "1" "1" "1" "314" "34.4" "9.16" "5.46" "1" "transport;other biological processes" "other membranes;ER/Golgi;other cell component" "" "Pf03878" "90522" "ENSG00000167645" "YIF1B" "H7BXS8; hsa:90522; Q5BJH7; Q5JPC2; Q8WY70; Q96C02; Q96IC4" "" "" "0" "0" "0.939" "1.077" "1.118" "1.136" "1.091" "1.068" "1.086" "0.984" "0.536" "102.8" "96.5" "110.7" "114.9" "116.8" "112.2" "109.8" "111.7" "101.2" "55.1" "" "" "" "" "" "" "" "" "" "" "91.2" "79.9" "96.6" "85.9" "97.4" "103.0" "92.8" "92.3" "92.8" "55.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6809936595777039335" "False" "High" "IsMasterProtein" "Q69YN4" "Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2" "0.000" "False" "7.560" "1" "2" "2" "2" "1812" "201.9" "5.01" "8.27" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15912" "25962" "ENSG00000164944" "VIRMA" "hsa:25962; Q2M1N0; Q69YN4; Q6AHX9; Q6NT78; Q7Z6C7; Q8IXH4; Q9BTH4; Q9H9C9; Q9NWR3; Q9P2B8; Q9UFW1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "862030187180184492" "False" "High" "IsMasterProtein" "O60238" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like OS=Homo sapiens OX=9606 GN=BNIP3L PE=1 SV=1" "0.000" "False" "7.555" "7" "1" "1" "1" "219" "23.9" "5.85" "4.51" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus" "other molecular function" "Pf06553" "665" "ENSG00000104765" "BNIP3L" "B0AZS9; hsa:665; O60238; Q5JW63; Q8NF87" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling" "3" "0" "1.494" "1.079" "1.222" "1.168" "1.428" "1.265" "1.371" "1.297" "0.501" "43.4" "64.8" "46.8" "53.0" "50.7" "61.9" "54.9" "59.5" "56.3" "21.7" "" "" "" "" "" "" "" "" "" "" "38.5" "53.7" "40.9" "39.6" "42.2" "56.9" "46.4" "49.2" "51.6" "21.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2326551540436449493" "False" "High" "IsMasterProtein" "Q6Y288" "Beta-1,3-glucosyltransferase OS=Homo sapiens OX=9606 GN=B3GLCT PE=1 SV=2" "0.000" "False" "7.529" "4" "2" "2" "2" "498" "56.5" "7.50" "7.16" "2" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02434" "145173" "ENSG00000187676" "B3GLCT" "A8K5F8; hsa:145173; Q5W0H2; Q6NUI3; Q6Y288" "Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins" "" "2" "0" "0.844" "0.945" "0.952" "1.019" "1.018" "1.064" "1.029" "1.082" "0.778" "338.4" "285.6" "319.7" "322.2" "344.9" "344.5" "360.0" "348.2" "366.3" "263.4" "" "" "" "" "" "" "" "" "" "" "300.1" "236.6" "279.0" "240.9" "287.6" "316.5" "304.2" "287.8" "336.0" "263.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251219974824346079" "False" "High" "IsMasterProtein" "Q05D32" "CTD small phosphatase-like protein 2 OS=Homo sapiens OX=9606 GN=CTDSPL2 PE=1 SV=2" "0.000" "False" "7.523" "3" "1" "1" "1" "466" "53.0" "6.40" "3.97" "1" "transport;other biological processes" "nucleus" "other molecular function" "Pf03031" "51496" "ENSG00000137770" "CTDSPL2" "hsa:51496; Q05D32; Q3ZTU1; Q6AI06; Q8IYI9; Q9NVT2; Q9NZX8; Q9P030" "" "" "0" "0" "1.041" "1.205" "1.239" "0.896" "0.703" "0.933" "0.813" "0.934" "2.303" "24.2" "25.2" "29.2" "30.0" "21.7" "17.0" "22.6" "19.7" "22.6" "55.7" "" "" "" "" "" "" "" "" "" "" "21.5" "20.9" "25.4" "22.4" "18.1" "15.6" "19.1" "16.3" "20.7" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3050786431982256186" "False" "High" "IsMasterProtein" "Q53ET0" "CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2" "0.000" "False" "7.520" "4" "2" "2" "2" "693" "73.3" "7.11" "7.57" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "200186" "ENSG00000160741" "CRTC2" "hsa:200186; Q53ET0; Q6UUV8; Q7Z3X7; Q8N332" "Circadian Clock; Heme signaling; Transcriptional activation of mitochondrial biogenesis" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129338671837300354" "False" "High" "IsMasterProtein" "P78559" "Microtubule-associated protein 1A OS=Homo sapiens OX=9606 GN=MAP1A PE=1 SV=6" "0.000" "False" "7.516" "1" "2" "2" "2" "2803" "305.3" "4.92" "7.40" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4130" "ENSG00000166963" "MAP1A" "hsa:4130; O95643; P78559; Q12973; Q15882; Q9UJT4" "" "" "0" "0" "0.822" "0.840" "0.893" "0.885" "0.817" "0.914" "0.990" "0.848" "0.989" "315.8" "259.6" "265.2" "282.1" "279.4" "258.1" "288.6" "312.6" "268.0" "312.5" "" "" "" "" "" "" "" "" "" "" "280.1" "215.0" "231.4" "211.0" "233.0" "237.1" "243.9" "258.4" "245.8" "312.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1834227978876737947" "False" "High" "IsMasterProtein" "Q96EP1" "E3 ubiquitin-protein ligase CHFR OS=Homo sapiens OX=9606 GN=CHFR PE=1 SV=2" "0.000" "False" "7.513" "2" "1" "2" "1" "664" "73.3" "6.04" "6.01" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00498, Pf13923, Pf17979" "55743" "ENSG00000072609" "CHFR" "A6NEN5; B4DZ77; B4E2L6; hsa:55743; Q96EP1; Q96SL3; Q9NRT4; Q9NT32; Q9NVD5" "" "" "0" "0" "1.119" "0.931" "1.145" "0.852" "0.958" "1.007" "0.818" "0.886" "1.749" "109.5" "122.5" "101.9" "125.3" "93.3" "104.9" "110.2" "89.5" "97.0" "191.5" "" "" "" "" "" "" "" "" "" "" "97.1" "101.5" "88.9" "93.7" "77.8" "96.3" "93.2" "74.0" "88.9" "191.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650910315331199742" "False" "High" "IsMasterProtein" "Q9NZA1" "Chloride intracellular channel protein 5 OS=Homo sapiens OX=9606 GN=CLIC5 PE=1 SV=3" "0.000" "False" "7.510" "4" "1" "1" "1" "410" "46.5" "4.82" "4.66" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "transporter activity" "Pf13409, Pf13410" "53405" "ENSG00000112782" "CLIC5" "B3KUF1; hsa:53405; Q5T4Z0; Q8NBY3; Q96JT5; Q9BWZ0; Q9NZA1" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "1.119" "1.098" "1.140" "1.116" "1.044" "1.166" "1.061" "0.951" "0.815" "169.7" "189.9" "186.4" "193.4" "189.4" "177.1" "197.9" "180.0" "161.3" "138.3" "" "" "" "" "" "" "" "" "" "" "150.5" "157.3" "162.6" "144.6" "157.9" "162.7" "167.3" "148.7" "147.9" "138.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2183833753679145319" "False" "High" "IsMasterProtein" "Q6ZNE5" "Beclin 1-associated autophagy-related key regulator OS=Homo sapiens OX=9606 GN=ATG14 PE=1 SV=1" "0.000" "False" "7.500" "4" "1" "1" "1" "492" "55.3" "7.01" "3.42" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf10186" "22863" "ENSG00000126775" "ATG14" "A6NJE4; A8K9U5; B7ZWP5; hsa:22863; O94920; Q32MK7; Q32MK8; Q6ZNE5" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2073188909526316483" "False" "High" "IsMasterProtein" "Q96RJ3" "Tumor necrosis factor receptor superfamily member 13C OS=Homo sapiens OX=9606 GN=TNFRSF13C PE=1 SV=1" "0.000" "False" "7.498" "11" "2" "2" "2" "184" "18.9" "8.21" "6.71" "2" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf09256" "115650" "ENSG00000159958" "TNFRSF13C" "hsa:115650; Q96RJ3" "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" "" "2" "0" "0.906" "0.933" "0.788" "0.926" "0.998" "0.951" "0.906" "1.027" "0.544" "305.9" "277.1" "285.4" "240.9" "283.4" "305.2" "290.9" "277.3" "314.2" "166.3" "" "" "" "" "" "" "" "" "" "" "271.3" "229.6" "249.1" "180.2" "236.3" "280.3" "245.9" "229.2" "288.1" "166.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4275613073034552076" "False" "High" "IsMasterProtein" "Q9NQI0" "Probable ATP-dependent RNA helicase DDX4 OS=Homo sapiens OX=9606 GN=DDX4 PE=1 SV=2" "0.000" "False" "7.497" "3" "3" "3" "1" "724" "79.3" "5.87" "5.91" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54514" "ENSG00000152670" "DDX4" "A8K8Q2; B3KSF4; D6RDK4; E9PCD8; hsa:54514; Q5M7Z3; Q86VX0; Q9NQI0; Q9NT92; Q9NYB1" "RND3 GTPase cycle; PIWI-interacting RNA (piRNA) biogenesis" "Male infertility" "3" "0" "0.892" "1.023" "0.988" "1.036" "1.014" "1.009" "1.009" "0.967" "0.618" "192.6" "171.8" "196.9" "190.3" "199.5" "195.3" "194.2" "194.3" "186.2" "119.0" "" "" "" "" "" "" "" "" "" "" "170.8" "142.3" "171.8" "142.3" "166.3" "179.4" "164.1" "160.6" "170.7" "119.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5183931904293870446" "False" "High" "IsMasterProtein" "Q96FX2" "Diphthamide biosynthesis protein 3 OS=Homo sapiens OX=9606 GN=DPH3 PE=1 SV=1" "0.000" "False" "7.496" "20" "1" "1" "1" "82" "9.2" "4.09" "5.53" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05207" "285381" "ENSG00000154813" "DPH3" "hsa:285381; Q96FX2" "Synthesis of diphthamide-EEF2" "" "1" "0" "0.968" "1.038" "0.974" "0.933" "1.102" "0.984" "1.069" "1.088" "0.549" "170.8" "165.3" "177.2" "166.3" "159.4" "188.1" "168.0" "182.6" "185.7" "93.7" "" "" "" "" "" "" "" "" "" "" "151.4" "136.9" "154.6" "124.3" "132.9" "172.8" "142.0" "150.9" "170.4" "93.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5223570774126061662" "False" "High" "IsMasterProtein" "Q9UKA4" "A-kinase anchor protein 11 OS=Homo sapiens OX=9606 GN=AKAP11 PE=1 SV=1" "0.000" "False" "7.493" "1" "2" "2" "2" "1901" "210.4" "5.39" "7.17" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "11215" "ENSG00000023516" "AKAP11" "hsa:11215; O75124; Q9NUK7; Q9UKA4" "" "G protein signaling pathways" "1" "0" "1.016" "0.949" "1.001" "0.970" "0.827" "0.934" "0.868" "0.917" "1.583" "133.1" "135.3" "126.4" "133.2" "129.1" "110.1" "124.4" "115.5" "122.1" "210.7" "" "" "" "" "" "" "" "" "" "" "118.0" "112.0" "110.2" "99.6" "107.7" "101.2" "105.1" "95.5" "112.0" "210.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2011789362582396358" "False" "High" "IsMasterProtein" "Q9NSI8" "SAM domain-containing protein SAMSN-1 OS=Homo sapiens OX=9606 GN=SAMSN1 PE=1 SV=1" "0.000" "False" "7.492" "5" "2" "2" "2" "373" "41.7" "5.43" "7.86" "2" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07647, Pf07653, Pf12485" "64092" "ENSG00000155307" "SAMSN1" "B3KWJ3; F8WAA1; hsa:64092; Q8NFF7; Q9C041; Q9NSI8" "" "TYROBP causal network in microglia" "1" "0" "1.242" "1.149" "1.051" "0.989" "1.175" "1.043" "1.130" "1.313" "1.522" "37.9" "47.0" "43.5" "39.8" "37.5" "44.5" "39.5" "42.8" "49.7" "57.6" "" "" "" "" "" "" "" "" "" "" "33.6" "39.0" "38.0" "29.8" "31.2" "40.9" "33.4" "35.4" "45.6" "57.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3856989344168059657" "False" "High" "IsMasterProtein" "P04440" "HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPB1 PE=1 SV=1" "0.000" "False" "7.480" "9" "2" "3" "1" "258" "29.1" "8.57" "9.07" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00969, Pf07654" "3115" "ENSG00000215048; ENSG00000223865; ENSG00000226826; ENSG00000230763; ENSG00000236693; ENSG00000237710" "HLA-DPB1" "A0PFJ7; A5I886; A8YPB3; B5U8B4; B7VF80; B7VF87; B8ZX68; B8ZYT0; B9W5S8; B9W6F7; B9W6F9; C0MPP5; C0MPQ2; C0MPQ3; C0MPQ5; C0MPQ6; C0MPQ7; C4R9J5; C5IZL1; hsa:3115; O00259; O19698; O19700; O19702; O19749; O46884; O77952; O98215; O98216; O98217; O98218; O98219; O98222; O98223; P01916; P04232; P04440; P13763; P79493; P79608; Q0P0L4; Q0ZFN3; Q14279; Q27S71; Q29682; Q29684; Q29698; Q29714; Q29775; Q29776; Q29778; Q29779; Q29781; Q29827; Q29828; Q29879; Q29880; Q29898; Q29977; Q2MGW3; Q30015; Q30031; Q30032; Q30033; Q30034; Q30050; Q30051; Q30052; Q30053; Q30054; Q30055; Q30174; Q4GY31; Q4JHD8; Q5ENE0; Q5ENE1; Q5ENW3; Q5EP46; Q5EP47; Q5EP49; Q5EP51; Q5EP52; Q5EP53; Q5EP56; Q5I4H8; Q5I4H9; Q5ISH4; Q5ISH5; Q5SQ73; Q5STP2; Q5YLA6; Q6IVX1; Q6LBX2; Q6LBX3; Q6LBX4; Q6LBX5; Q6LBX6; Q6LBX7; Q6PWX6; Q6TAS4; Q714U1; Q714U2; Q7YQ10; Q860Z7; Q8HWL7; Q8HWT5; Q8SNC4; Q95HC1; Q95IT7; Q95IT8; Q9BD13; Q9GIM2; Q9GIM4; Q9GIX6; Q9GJ41; Q9MY67; Q9TNT7; Q9TQE2; Q9XS11; Q9XS12" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7198883007019988074" "False" "High" "IsMasterProtein" "Cont_Q8N1N4" "Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2" "0.000" "True" "7.476" "4" "3" "3" "1" "520" "56.8" "6.02" "9.16" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "196374" "ENSG00000170423" "KRT78" "A8K4D6; hsa:196374; Q5HYM7; Q7RTT2; Q8N1N4" "Formation of the cornified envelope" "" "2" "0" "0.896" "1.094" "2.703" "0.923" "4.719" "1.017" "0.981" "1.686" "1.234" "81.4" "72.9" "89.0" "219.9" "75.1" "384.0" "82.7" "79.8" "137.2" "100.4" "" "" "" "" "" "" "" "" "" "" "72.2" "60.4" "77.6" "164.5" "62.6" "352.7" "69.9" "66.0" "125.8" "100.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3836342718594531018" "False" "High" "IsMasterProtein" "O94921" "Cyclin-dependent kinase 14 OS=Homo sapiens OX=9606 GN=CDK14 PE=1 SV=3" "0.000" "False" "7.474" "4" "2" "2" "1" "469" "53.0" "8.92" "7.60" "2" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5218" "ENSG00000058091" "CDK14" "A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2; hsa:5218; O94921; Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0" "" "" "0" "0" "1.055" "1.180" "1.035" "1.051" "1.013" "1.079" "0.899" "1.011" "2.332" "163.6" "172.5" "193.1" "169.3" "171.8" "165.7" "176.5" "147.1" "165.3" "381.5" "" "" "" "" "" "" "" "" "" "" "145.0" "142.9" "168.5" "126.6" "143.3" "152.3" "149.1" "121.6" "151.6" "381.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8284238636204058058" "False" "High" "IsMasterProtein" "O00217" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS8 PE=1 SV=1" "0.000" "False" "7.472" "12" "2" "2" "2" "210" "23.7" "6.34" "8.37" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf12838" "4728" "ENSG00000110717" "NDUFS8" "B2RB86; hsa:4728; O00217; Q0VDA8" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.910" "0.884" "1.026" "0.919" "0.927" "0.898" "0.937" "0.885" "0.779" "115.5" "105.1" "102.1" "118.4" "106.1" "107.1" "103.6" "108.2" "102.2" "89.9" "" "" "" "" "" "" "" "" "" "" "102.4" "87.1" "89.1" "88.6" "88.5" "98.4" "87.6" "89.4" "93.8" "89.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "High" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.000" "False" "7.470" "3" "2" "2" "2" "520" "60.7" "6.77" "6.67" "2" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "1.059" "1.103" "1.143" "1.101" "1.089" "1.148" "1.130" "1.109" "0.788" "419.3" "444.1" "462.3" "479.3" "461.7" "456.6" "481.4" "473.9" "464.8" "330.6" "" "" "" "" "" "" "" "" "" "" "371.8" "367.9" "403.3" "358.4" "385.0" "419.5" "406.9" "391.7" "426.3" "330.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8022290740510184659" "False" "High" "IsMasterProtein" "P49257" "Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2" "0.000" "False" "7.458" "4" "2" "3" "2" "510" "57.5" "6.77" "6.79" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03388" "3998" "ENSG00000074695" "LMAN1" "hsa:3998; P49257; Q12895; Q8N5I7; Q9UQG1; Q9UQG2; Q9UQG3; Q9UQG4; Q9UQG5; Q9UQG6; Q9UQG7; Q9UQG8; Q9UQG9; Q9UQH0; Q9UQH1; Q9UQH2" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Complement and coagulation cascades" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3573603970106114423" "False" "High" "IsMasterProtein" "Q9H2F5" "Enhancer of polycomb homolog 1 OS=Homo sapiens OX=9606 GN=EPC1 PE=1 SV=1" "0.000" "False" "7.446" "2" "2" "5" "2" "836" "93.4" "8.59" "10.05" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf06752, Pf10513" "80314" "ENSG00000120616" "EPC1" "B4DSC3; D3DRX7; hsa:80314; Q5VW54; Q5VW56; Q5VW58; Q8NAQ4; Q8NE21; Q96LF4; Q96RR6; Q9H2F5; Q9H7T7" "Transcriptional Regulation by E2F6; HATs acetylate histones" "" "2" "0" "1.042" "0.992" "1.093" "1.021" "0.953" "1.065" "1.069" "0.885" "0.662" "508.8" "530.4" "504.7" "556.0" "519.5" "485.1" "542.0" "543.7" "450.4" "336.8" "" "" "" "" "" "" "" "" "" "" "451.2" "439.4" "440.4" "415.8" "433.2" "445.6" "458.1" "449.4" "413.1" "336.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "7.442" "1" "2" "3" "2" "2426" "263.7" "5.64" "10.20" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "1.024" "0.830" "0.707" "0.623" "0.474" "0.531" "0.562" "0.697" "1.838" "131.7" "134.9" "109.3" "93.1" "82.0" "62.4" "69.9" "74.0" "91.8" "242.1" "" "" "" "" "" "" "" "" "" "" "116.8" "111.8" "95.4" "69.6" "68.4" "57.3" "59.1" "61.2" "84.2" "242.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6926714013123619356" "False" "High" "IsMasterProtein" "Q92610" "Zinc finger protein 592 OS=Homo sapiens OX=9606 GN=ZNF592 PE=1 SV=2" "0.000" "False" "7.438" "2" "2" "2" "2" "1267" "137.4" "7.84" "5.63" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf16622" "9640" "ENSG00000166716" "ZNF592" "hsa:9640; Q2M1T2; Q504Y9; Q92610" "" "15q25 copy number variation" "1" "0" "1.449" "1.515" "1.473" "0.984" "0.875" "1.206" "1.459" "0.940" "4.354" "10.7" "15.5" "16.2" "15.7" "10.5" "9.3" "12.9" "15.6" "10.0" "46.4" "" "" "" "" "" "" "" "" "" "" "9.5" "12.8" "14.1" "11.7" "8.8" "8.6" "10.9" "12.9" "9.2" "46.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2370626703481031957" "False" "High" "IsMasterProtein" "Q9H7N4" "Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3" "0.000" "False" "7.409" "1" "1" "1" "1" "1312" "139.2" "9.25" "4.09" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "58506" "ENSG00000126461" "SCAF1" "hsa:58506; Q7Z5V7; Q8WVA1; Q9H7N4; Q9NR59" "" "" "0" "0" "1.137" "1.053" "1.207" "0.925" "1.115" "1.081" "1.146" "1.095" "1.154" "110.4" "125.4" "116.2" "133.2" "102.0" "123.0" "119.3" "126.4" "120.9" "127.3" "" "" "" "" "" "" "" "" "" "" "97.9" "103.9" "101.4" "99.6" "85.1" "113.0" "100.8" "104.5" "110.9" "127.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2486972886246464504" "False" "High" "IsMasterProtein" "O00221" "NF-kappa-B inhibitor epsilon OS=Homo sapiens OX=9606 GN=NFKBIE PE=1 SV=3" "0.000" "False" "7.405" "4" "1" "1" "1" "500" "52.8" "6.68" "4.52" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00023" "4794" "ENSG00000146232" "NFKBIE" "hsa:4794; O00221; Q5T9V9" "Activation of NF-kappaB in B cells" "TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19" "7" "0" "1.093" "0.881" "1.017" "0.914" "1.081" "0.934" "0.918" "0.907" "1.273" "163.7" "178.9" "144.3" "166.4" "149.6" "177.0" "153.0" "150.2" "148.5" "208.5" "" "" "" "" "" "" "" "" "" "" "145.2" "148.2" "125.9" "124.5" "124.8" "162.6" "129.3" "124.2" "136.2" "208.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552145293122951673" "False" "High" "IsMasterProtein" "Q96P48" "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3" "0.000" "False" "7.403" "2" "3" "3" "3" "1450" "162.1" "6.23" "7.47" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00536, Pf00620, Pf00788, Pf01412" "116985" "ENSG00000186635" "ARAP1" "A3KLL7; B2RTS2; hsa:116985; O94879; Q4LDD5; Q59FI7; Q6PHS3; Q8WU51; Q96HP6; Q96L71; Q96P48" "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "" "4" "0" "0.803" "0.624" "0.722" "0.647" "0.548" "0.670" "0.379" "0.861" "6.930" "107.1" "86.0" "66.8" "77.3" "69.3" "58.7" "71.8" "40.6" "92.2" "742.2" "" "" "" "" "" "" "" "" "" "" "95.0" "71.2" "58.3" "57.8" "57.8" "53.9" "60.6" "33.6" "84.6" "742.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5543931740707389178" "False" "High" "IsMasterProtein" "Cont_Q28065" "C4b-binding protein alpha chain OS=Bos taurus OX=9913 GN=C4BPA PE=2 SV=1" "0.000" "True" "7.399" "5" "3" "3" "3" "610" "68.8" "6.38" "9.81" "3" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "" "Pf00084, Pf18453" "281651" "ENSBIXG00000017034; ENSBTAG00000009876" "C4BPA; LOC113906358" "A0A4W2EK29; bta:281651; Q28065; Q2KJ87" "" "" "0" "0" "1.019" "0.907" "0.897" "0.934" "0.881" "0.998" "0.892" "1.008" "0.722" "448.6" "457.1" "407.0" "402.4" "418.9" "395.4" "447.7" "400.4" "452.1" "324.0" "" "" "" "" "" "" "" "" "" "" "397.8" "378.7" "355.1" "301.0" "349.3" "363.2" "378.4" "330.9" "414.7" "324.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2534211096191502147" "False" "High" "IsMasterProtein" "O00560" "Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1" "0.000" "False" "7.397" "7" "2" "3" "2" "298" "32.4" "7.53" "8.44" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595" "6386" "ENSG00000137575" "SDCBP" "B2R5Q7; B4DUH3; B7ZLN2; O00173; O00560; O43391; Q14CP2" "Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death" "Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling; 11p11.2 copy number variation syndrome" "9" "0" "0.966" "0.893" "1.009" "0.956" "0.908" "0.932" "1.023" "0.970" "1.044" "328.9" "317.6" "293.8" "331.8" "314.5" "298.5" "306.7" "336.5" "319.1" "343.3" "" "" "" "" "" "" "" "" "" "" "291.6" "263.1" "256.3" "248.1" "262.2" "274.2" "259.2" "278.1" "292.7" "343.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3308580739570590446" "False" "High" "IsMasterProtein" "Q8WVL7" "Ankyrin repeat domain-containing protein 49 OS=Homo sapiens OX=9606 GN=ANKRD49 PE=1 SV=1" "0.000" "False" "7.377" "9" "2" "3" "2" "239" "27.3" "5.15" "9.45" "2" "other biological processes" "nucleus" "" "Pf12796" "54851" "ENSG00000168876" "ANKRD49" "hsa:54851; Q8NDF2; Q8WVL7; Q96JE5; Q9NXK7" "" "" "0" "0" "1.201" "1.173" "1.224" "1.164" "1.069" "1.225" "1.097" "1.029" "0.695" "42.7" "51.2" "50.0" "52.2" "49.7" "45.6" "52.3" "46.8" "43.9" "29.6" "" "" "" "" "" "" "" "" "" "" "37.8" "42.4" "43.7" "39.0" "41.4" "41.9" "44.2" "38.7" "40.2" "29.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-150019997035989311" "False" "High" "IsMasterProtein" "Q96JK2" "DDB1- and CUL4-associated factor 5 OS=Homo sapiens OX=9606 GN=DCAF5 PE=1 SV=2" "0.000" "False" "7.368" "1" "1" "1" "1" "942" "103.9" "5.76" "4.48" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "8816" "ENSG00000139990" "DCAF5" "B2RN31; G3V4J7; hsa:8816; O60559; Q8N3V3; Q8N3V5; Q96JK2" "Neddylation" "" "1" "0" "1.001" "0.966" "1.087" "1.012" "0.908" "1.056" "0.864" "0.892" "2.063" "94.4" "94.5" "91.2" "102.7" "95.5" "85.7" "99.7" "81.6" "84.2" "194.8" "" "" "" "" "" "" "" "" "" "" "83.7" "78.3" "79.6" "76.8" "79.7" "78.8" "84.3" "67.4" "77.2" "194.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3307427478696066462" "False" "High" "IsMasterProtein" "Q96AJ9" "Vesicle transport through interaction with t-SNAREs homolog 1A OS=Homo sapiens OX=9606 GN=VTI1A PE=1 SV=2" "0.000" "False" "7.351" "11" "2" "2" "2" "217" "25.2" "6.40" "7.12" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "143187" "ENSG00000151532" "VTI1A" "A2A307; B4E137; hsa:143187; Q5W0D7; Q96AJ9" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "2" "0" "1.146" "1.108" "1.111" "0.939" "1.190" "0.920" "1.043" "1.077" "0.644" "80.2" "91.8" "88.9" "89.1" "75.2" "95.4" "73.7" "83.6" "86.3" "51.7" "" "" "" "" "" "" "" "" "" "" "71.1" "76.1" "77.5" "66.6" "62.7" "87.6" "62.3" "69.1" "79.2" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5001588694076632996" "False" "High" "IsMasterProtein" "O94876" "Transmembrane and coiled-coil domains protein 1 OS=Homo sapiens OX=9606 GN=TMCC1 PE=1 SV=3" "0.000" "False" "7.348" "4" "3" "3" "3" "653" "72.0" "6.55" "9.83" "3" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf10267" "23023" "ENSG00000172765" "TMCC1" "A8K5Y3; B4DE04; hsa:23023; O94876; Q68E06; Q8IXM8" "" "" "0" "0" "0.414" "0.435" "0.390" "0.339" "0.353" "0.317" "0.335" "0.382" "0.247" "1081.8" "447.7" "470.2" "421.4" "366.7" "382.2" "342.8" "362.1" "412.9" "267.4" "" "" "" "" "" "" "" "" "" "" "959.3" "370.9" "410.3" "315.1" "305.7" "351.1" "289.7" "299.3" "378.7" "267.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7805549353878953757" "False" "High" "IsMasterProtein" "Cont_P17697" "Clusterin OS=Bos taurus OX=9913 GN=CLU PE=1 SV=1" "0.000" "True" "7.343" "2" "1" "1" "1" "439" "51.1" "6.04" "3.78" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01093" "104988313; 280750" "ENSBIXG00000022175; ENSBTAG00000005574" "CLU; LOC104988313" "A0A4W2D277; A0A6P3HH17; A5D983; bbis:104988313; bta:280750; P17697; Q148K1" "Platelet degranulation ; Regulation of Complement cascade; Terminal pathway of complement; Antimicrobial peptides" "" "4" "0" "0.954" "0.688" "0.808" "0.879" "0.812" "1.022" "0.894" "0.750" "0.535" "51.4" "49.0" "35.3" "41.5" "45.1" "41.7" "52.5" "45.9" "38.5" "27.5" "" "" "" "" "" "" "" "" "" "" "45.5" "40.6" "30.8" "31.0" "37.6" "38.3" "44.4" "38.0" "35.3" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4790562829176069588" "False" "High" "IsMasterProtein" "Q9BV19" "Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2" "0.000" "False" "7.343" "10" "2" "3" "2" "199" "21.9" "5.88" "10.33" "2" "" "" "other molecular function" "Pf10504" "79078" "ENSG00000164008" "C1orf50" "Q9BV19" "" "" "0" "0" "1.093" "0.998" "0.991" "0.980" "1.076" "0.951" "0.946" "0.897" "0.655" "372.6" "407.4" "371.8" "369.2" "365.1" "400.7" "354.3" "352.5" "334.2" "244.0" "" "" "" "" "" "" "" "" "" "" "330.4" "337.5" "324.5" "276.1" "304.4" "368.1" "299.4" "291.3" "306.5" "244.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.000" "False" "7.329" "4" "3" "4" "3" "563" "65.1" "5.05" "11.32" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.024" "0.691" "0.899" "0.730" "0.789" "0.664" "0.100" "0.786" "18.955" "174.7" "179.0" "120.8" "157.1" "127.5" "137.9" "116.1" "17.5" "137.3" "3312.2" "" "" "" "" "" "" "" "" "" "" "155.0" "148.3" "105.4" "117.5" "106.3" "126.6" "98.1" "14.4" "125.9" "3312.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8661792749536584000" "False" "High" "IsMasterProtein" "Q86YT9" "Junctional adhesion molecule-like OS=Homo sapiens OX=9606 GN=JAML PE=1 SV=1" "0.000" "False" "7.314" "5" "2" "2" "2" "394" "44.3" "7.12" "6.72" "2" "cell adhesion;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07686" "120425" "ENSG00000160593" "JAML" "B0YIV1; B0YIV2; hsa:120425; Q496M1; Q5DTC6; Q7Z499; Q86YT9; Q8N9I7; Q8NF70" "Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "2" "0" "1.058" "1.016" "1.157" "1.031" "1.158" "1.120" "1.068" "1.049" "0.512" "196.8" "208.2" "200.0" "227.7" "202.9" "227.8" "220.5" "210.2" "206.4" "100.7" "" "" "" "" "" "" "" "" "" "" "174.5" "172.5" "174.5" "170.3" "169.2" "209.3" "186.3" "173.7" "189.3" "100.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8018768357268208371" "False" "High" "IsMasterProtein" "Q9P1U0" "DNA-directed RNA polymerase I subunit RPA12 OS=Homo sapiens OX=9606 GN=POLR1H PE=1 SV=1" "0.000" "False" "7.314" "9" "1" "2" "1" "126" "13.9" "5.06" "6.27" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096" "30834" "ENSG00000066379; ENSG00000206502; ENSG00000224859; ENSG00000233795; ENSG00000235176; ENSG00000235443; ENSG00000236808; ENSG00000236949" "POLR1H" "hsa:30834; Q9P1U0" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852376921802983428" "False" "High" "IsMasterProtein" "Q9UN19" "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide OS=Homo sapiens OX=9606 GN=DAPP1 PE=1 SV=1" "0.000" "False" "7.290" "4" "1" "1" "1" "280" "32.2" "7.80" "4.74" "1" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00017, Pf00169" "27071" "ENSG00000070190" "DAPP1" "hsa:27071; Q8TCK5; Q9UHF2; Q9UN19" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway" "2" "0" "1.379" "1.250" "1.261" "1.223" "1.201" "1.031" "0.768" "1.118" "6.108" "96.0" "132.3" "120.0" "121.0" "117.4" "115.3" "99.0" "73.7" "107.3" "586.3" "" "" "" "" "" "" "" "" "" "" "85.1" "109.6" "104.7" "90.5" "97.9" "105.9" "83.6" "60.9" "98.4" "586.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257899417113298170" "False" "High" "IsMasterProtein" "P78316" "Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3" "0.000" "False" "7.288" "2" "2" "2" "2" "857" "97.6" "7.58" "6.88" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04147" "8602" "ENSG00000087269" "NOP14" "D3DVR6; hsa:8602; P78316; Q7LGI5; Q7Z6K0; Q8TBR6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.844" "0.719" "0.739" "0.608" "0.659" "0.548" "0.672" "0.809" "0.699" "254.4" "214.7" "183.0" "188.0" "154.8" "167.6" "139.3" "171.0" "205.8" "177.9" "" "" "" "" "" "" "" "" "" "" "225.6" "177.9" "159.6" "140.6" "129.0" "154.0" "117.8" "141.3" "188.7" "177.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5221985020490519737" "False" "High" "IsMasterProtein" "Q6PJI9" "GATOR2 complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2" "0.000" "False" "7.284" "3" "2" "3" "2" "974" "109.7" "7.91" "7.05" "2" "stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf17120" "79726" "ENSG00000103091" "WDR59" "B3KRC3; hsa:79726; Q6PJI9; Q71RE7; Q96PW5; Q9BSW6; Q9HA43" "Amino acids regulate mTORC1" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711116662832737595" "False" "High" "IsMasterProtein" "Q53EZ4" "Centrosomal protein of 55 kDa OS=Homo sapiens OX=9606 GN=CEP55 PE=1 SV=3" "0.000" "False" "7.263" "4" "2" "2" "2" "464" "54.1" "7.01" "5.44" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf12180" "55165" "ENSG00000138180" "CEP55" "B2RDG8; D3DR37; hsa:55165; Q32WF5; Q3MV20; Q53EZ4; Q5VY28; Q6N034; Q96H32; Q9NVS7" "" "" "0" "0" "0.967" "0.869" "0.972" "0.953" "0.925" "0.936" "0.717" "0.961" "3.458" "168.2" "162.6" "146.2" "163.5" "160.2" "155.6" "157.4" "120.6" "161.6" "581.5" "" "" "" "" "" "" "" "" "" "" "149.1" "134.7" "127.6" "122.3" "133.6" "143.0" "133.1" "99.7" "148.2" "581.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1322604588450231993" "False" "High" "IsMasterProtein" "P31629" "Transcription factor HIVEP2 OS=Homo sapiens OX=9606 GN=HIVEP2 PE=1 SV=2" "0.000" "False" "7.260" "1" "2" "2" "2" "2446" "268.9" "6.96" "4.15" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "3097" "ENSG00000010818" "HIVEP2" "hsa:3097; P31629; Q02646; Q5THT5; Q9NS05" "" "Rett syndrome" "1" "0" "1.027" "0.951" "0.890" "0.872" "0.834" "0.840" "0.863" "1.003" "1.444" "243.5" "249.9" "231.4" "216.6" "212.2" "203.1" "204.5" "210.0" "244.1" "351.6" "" "" "" "" "" "" "" "" "" "" "215.9" "207.0" "201.9" "162.0" "176.9" "186.6" "172.9" "173.6" "223.9" "351.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1619272264168287387" "False" "High" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "0.000" "False" "7.242" "2" "1" "1" "1" "735" "79.3" "4.91" "3.93" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf13174, Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-895527807797415596" "False" "High" "IsMasterProtein" "O14556" "Glyceraldehyde-3-phosphate dehydrogenase, testis-specific OS=Homo sapiens OX=9606 GN=GAPDHS PE=1 SV=2" "0.000" "False" "7.240" "11" "4" "15" "3" "408" "44.5" "8.19" "35.29" "4" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00044, Pf02800" "26330" "ENSG00000105679" "GAPDHS" "B2RC82; hsa:26330; O14556; O60823; Q6JTT9; Q9HCU6" "Glycolysis; Gluconeogenesis; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "0.783" "1.205" "0.902" "0.813" "0.937" "0.979" "0.884" "0.973" "0.503" "272.0" "212.9" "327.7" "245.2" "221.2" "254.8" "266.4" "240.3" "264.7" "136.7" "" "" "" "" "" "" "" "" "" "" "241.2" "176.4" "285.9" "183.4" "184.4" "234.1" "225.1" "198.6" "242.8" "136.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534068984681137235" "False" "High" "IsMasterProtein" "Q86WQ0" "Nuclear receptor 2C2-associated protein OS=Homo sapiens OX=9606 GN=NR2C2AP PE=1 SV=1" "0.000" "False" "7.232" "9" "1" "2" "1" "139" "15.9" "6.16" "7.99" "1" "" "nucleus" "" "" "126382" "ENSG00000184162" "NR2C2AP" "A6NGP7; B4DW92; hsa:126382; Q86WQ0" "Nuclear Receptor transcription pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387955691257056682" "False" "High" "IsMasterProtein" "O43318" "Mitogen-activated protein kinase kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP3K7 PE=1 SV=1" "0.000" "False" "7.218" "3" "2" "2" "2" "606" "67.2" "7.11" "7.28" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "6885" "ENSG00000135341" "MAP3K7" "B2RE27; E1P523; hsa:6885; O43317; O43318; O43319; Q5TDN2; Q5TDN3; Q5TDT7; Q9NTR3; Q9NZ70" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNA role in immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "50" "0" "1.002" "0.801" "0.984" "0.775" "0.791" "1.030" "0.532" "0.829" "5.483" "111.9" "112.0" "89.6" "110.1" "86.7" "88.5" "115.2" "59.5" "92.8" "613.3" "" "" "" "" "" "" "" "" "" "" "99.2" "92.8" "78.2" "82.3" "72.3" "81.3" "97.4" "49.2" "85.1" "613.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634393773107864734" "False" "High" "IsMasterProtein" "P19474" "E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1" "0.000" "False" "7.216" "5" "3" "3" "3" "475" "54.1" "6.38" "7.88" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00622, Pf00643, Pf13765" "6737" "ENSG00000132109" "TRIM21" "hsa:6737; P19474; Q5XPV5; Q96RF8" "Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses" "" "5" "0" "1.417" "1.035" "1.981" "1.451" "1.280" "1.413" "0.910" "1.344" "5.463" "74.8" "105.9" "77.4" "148.1" "108.5" "95.7" "105.7" "68.1" "100.5" "408.5" "" "" "" "" "" "" "" "" "" "" "66.3" "87.8" "67.6" "110.8" "90.5" "87.9" "89.3" "56.3" "92.2" "408.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993585736520024209" "False" "High" "IsMasterProtein" "Q9BU68" "Proline-rich protein 15-like protein OS=Homo sapiens OX=9606 GN=PRR15L PE=1 SV=1" "0.000" "False" "7.213" "17" "1" "1" "1" "103" "11.7" "9.50" "5.99" "1" "" "" "" "Pf15321" "79170" "ENSG00000167183" "PRR15L" "D3DTU0; hsa:79170; Q9BU68" "" "Pancreatic cancer subtypes" "1" "0" "0.932" "0.885" "1.091" "1.120" "0.855" "0.960" "1.009" "0.926" "0.882" "116.8" "108.9" "103.3" "127.4" "130.8" "99.8" "112.1" "117.8" "108.2" "103.0" "" "" "" "" "" "" "" "" "" "" "103.6" "90.2" "90.2" "95.3" "109.0" "91.7" "94.7" "97.4" "99.2" "103.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3526658263404779392" "False" "High" "IsMasterProtein" "Q9UBI1" "COMM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=COMMD3 PE=1 SV=1" "0.000" "False" "7.199" "12" "2" "2" "2" "195" "22.1" "5.99" "6.68" "2" "transport" "non-structural extracellular;nucleus;other cell component" "" "Pf07258" "23412" "ENSG00000148444" "COMMD3" "D3DRU7; hsa:23412; Q5T8Y9; Q9UBI1" "Neddylation; Neutrophil degranulation" "" "2" "0" "1.181" "1.073" "1.184" "1.084" "0.964" "1.236" "1.072" "1.178" "3.772" "40.6" "48.0" "43.6" "48.1" "44.0" "39.2" "50.2" "43.5" "47.9" "153.2" "" "" "" "" "" "" "" "" "" "" "36.0" "39.7" "38.0" "36.0" "36.7" "36.0" "42.4" "36.0" "43.9" "153.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9192957103143993371" "False" "High" "IsMasterProtein" "Cont_Q9TTE1" "Serpin A3-1 OS=Bos taurus OX=9913 GN=SERPINA3-1 PE=1 SV=3" "0.000" "True" "7.195" "5" "2" "2" "2" "411" "46.2" "5.99" "7.59" "2" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "286804" "" "SERPINA3-1" "bta:286804; Q2KIQ9; Q3ZEJ7; Q9TTE1" "" "" "0" "0" "1.118" "1.029" "1.269" "1.303" "0.871" "1.172" "1.192" "0.939" "0.657" "132.8" "148.5" "136.6" "168.5" "173.1" "115.6" "155.6" "158.3" "124.6" "87.2" "" "" "" "" "" "" "" "" "" "" "117.7" "123.0" "119.2" "126.0" "144.3" "106.2" "131.5" "130.8" "114.3" "87.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532821643516687408" "False" "High" "IsMasterProtein" "Q6P158" "Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2" "0.000" "False" "7.187" "1" "2" "2" "1" "1386" "155.5" "7.71" "6.61" "2" "" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf05773, Pf07717, Pf18044, Pf21010" "90957" "ENSG00000163214" "DHX57" "A2RRC7; hsa:90957; Q53SI4; Q6P158; Q6P9G1; Q7Z6H3; Q8NG17; Q96M33" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5131911605729766219" "False" "High" "IsMasterProtein" "O60516" "Eukaryotic translation initiation factor 4E-binding protein 3 OS=Homo sapiens OX=9606 GN=EIF4EBP3 PE=1 SV=1" "0.000" "False" "7.166" "18" "1" "2" "1" "100" "10.9" "4.48" "5.17" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf05456" "8637" "ENSG00000243056" "EIF4EBP3" "hsa:8637; O60516" "" "Translation factors" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-331948696601358906" "False" "High" "IsMasterProtein" "Q969T7" "7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4" "0.000" "False" "7.160" "6" "2" "2" "2" "300" "34.4" "6.38" "6.87" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf05822" "115024" "ENSG00000141698" "NT5C3B" "A8MWB9; C9JKC4; hsa:115024; Q7L3B7; Q969T7" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "0.853" "0.865" "0.898" "0.837" "0.928" "0.789" "0.636" "0.742" "1.396" "302.3" "257.8" "261.4" "271.4" "252.9" "280.6" "238.5" "192.4" "224.2" "421.9" "" "" "" "" "" "" "" "" "" "" "268.0" "213.6" "228.1" "203.0" "210.9" "257.8" "201.6" "159.0" "205.6" "421.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946997143680763818" "False" "High" "IsMasterProtein" "Q8TDG4" "Helicase POLQ-like OS=Homo sapiens OX=9606 GN=HELQ PE=1 SV=2" "0.000" "False" "7.159" "2" "2" "2" "2" "1101" "124.1" "6.58" "6.54" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf20470, Pf21099" "113510" "ENSG00000163312" "HELQ" "hsa:113510; Q05DF9; Q502W9; Q659B8; Q6ZQX4; Q6ZTS4; Q8TDG4; Q96EX7" "" "Primary ovarian insufficiency" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-789511479774361380" "False" "High" "IsMasterProtein" "Q14202" "Zinc finger MYM-type protein 3 OS=Homo sapiens OX=9606 GN=ZMYM3 PE=1 SV=2" "0.000" "False" "7.159" "1" "2" "3" "2" "1370" "152.3" "6.35" "9.86" "2" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9203" "ENSG00000147130" "ZMYM3" "D3DVV3; hsa:9203; O15089; Q14202; Q96E26" "" "Orexin receptor pathway" "1" "0" "0.983" "0.979" "0.944" "1.034" "1.054" "1.007" "1.024" "1.086" "1.188" "325.9" "320.4" "319.2" "307.8" "337.1" "343.5" "328.3" "333.9" "353.9" "387.1" "" "" "" "" "" "" "" "" "" "" "289.0" "265.4" "278.5" "230.2" "281.1" "315.6" "277.5" "276.0" "324.6" "387.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723466212240730486" "False" "High" "IsMasterProtein" "Q13574" "Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=4" "0.000" "False" "7.141" "3" "2" "2" "2" "928" "103.9" "8.05" "5.17" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00023, Pf00130, Pf00609, Pf00781" "8525" "ENSG00000149091" "DGKZ" "B7Z2M9; B7Z6M3; E9PPW4; F6UCU9; G3V0F6; hsa:8525; J3KNJ6; O00542; Q13574; Q6ZVG7; Q8IVW9" "Effects of PIP2 hydrolysis" "Myometrial relaxation and contraction pathways; Leptin-insulin signaling overlap; Glycerolipids and glycerophospholipids; Modulators of TCR signaling and T cell activation" "5" "0" "1.077" "1.026" "1.193" "0.886" "1.050" "1.131" "1.086" "0.919" "2.701" "19.2" "20.7" "19.7" "22.9" "17.0" "20.1" "21.7" "20.8" "17.6" "51.8" "" "" "" "" "" "" "" "" "" "" "17.0" "17.1" "17.2" "17.1" "14.2" "18.5" "18.3" "17.2" "16.2" "51.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3585506896184313716" "False" "High" "IsMasterProtein" "P63218" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens OX=9606 GN=GNG5 PE=1 SV=3" "0.000" "False" "7.132" "13" "1" "2" "1" "68" "7.3" "9.85" "5.57" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2787" "ENSG00000174021" "GNG5" "B2R5A0; hsa:2787; P30670; P63218; Q5VX54; Q61015" "G alpha (i) signalling events; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Pathways in cancer" "36" "0" "1.033" "1.079" "1.026" "1.117" "1.101" "1.095" "1.106" "1.292" "0.337" "131.5" "135.8" "141.9" "134.9" "146.8" "144.7" "143.9" "145.4" "169.9" "44.3" "" "" "" "" "" "" "" "" "" "" "116.6" "112.5" "123.8" "100.9" "122.4" "132.9" "121.6" "120.2" "155.8" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9176436912319366181" "False" "High" "IsMasterProtein" "Q9Y5Q9" "General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1" "0.000" "False" "7.130" "1" "1" "1" "1" "886" "101.2" "5.07" "5.11" "1" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13181" "9330" "ENSG00000119041" "GTF3C3" "hsa:9330; Q4ZG48; Q86XJ8; Q8WX84; Q96B44; Q9H5I8; Q9NT97; Q9Y5Q9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "1.001" "0.917" "1.006" "1.037" "1.080" "1.145" "0.739" "1.030" "6.242" "78.1" "78.2" "71.6" "78.6" "81.0" "84.3" "89.5" "57.7" "80.5" "487.6" "" "" "" "" "" "" "" "" "" "" "69.3" "64.8" "62.5" "58.8" "67.6" "77.5" "75.6" "47.7" "73.8" "487.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.000" "False" "7.130" "16" "2" "9" "2" "102" "11.2" "9.32" "23.53" "2" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.000" "False" "7.114" "2" "2" "2" "2" "981" "110.5" "5.55" "3.62" "2" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "" "2" "0" "1.146" "0.984" "1.080" "1.024" "0.992" "1.155" "0.546" "1.085" "8.523" "105.6" "121.0" "104.0" "114.0" "108.1" "104.7" "121.9" "57.7" "114.6" "900.0" "" "" "" "" "" "" "" "" "" "" "93.6" "100.3" "90.7" "85.3" "90.2" "96.2" "103.1" "47.7" "105.1" "900.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7022499983038261226" "False" "High" "IsMasterProtein" "Q1ED39" "Lysine-rich nucleolar protein 1 OS=Homo sapiens OX=9606 GN=KNOP1 PE=1 SV=1" "0.000" "False" "7.114" "4" "1" "1" "1" "458" "51.6" "9.86" "5.31" "1" "" "nucleus" "" "Pf15477" "400506" "ENSG00000103550" "KNOP1" "O43328; Q1ED39; Q5FWF3" "" "" "0" "0" "0.703" "0.806" "0.862" "0.756" "0.689" "0.898" "0.733" "0.719" "0.598" "86.5" "60.8" "69.7" "74.5" "65.4" "59.6" "77.7" "63.4" "62.2" "51.7" "" "" "" "" "" "" "" "" "" "" "76.7" "50.4" "60.8" "55.7" "54.5" "54.8" "65.7" "52.4" "57.1" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316364973511523624" "False" "High" "IsMasterProtein" "Q8IYI6" "Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2" "0.000" "False" "7.112" "3" "2" "3" "2" "725" "81.7" "5.49" "8.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf08700, Pf16528" "149371" "ENSG00000116903" "EXOC8" "B3KU33; hsa:149371; Q5TE82; Q8IYI6" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "RalA downstream regulated genes; Ciliary landscape" "5" "0" "1.298" "0.934" "1.122" "0.971" "0.936" "1.098" "0.129" "1.090" "20.024" "49.5" "64.3" "46.2" "55.5" "48.0" "46.3" "54.3" "6.4" "54.0" "991.2" "" "" "" "" "" "" "" "" "" "" "43.9" "53.2" "40.3" "41.5" "40.1" "42.6" "45.9" "5.3" "49.5" "991.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7945437556686127836" "False" "High" "IsMasterProtein" "Q96GA3" "Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1" "0.000" "False" "7.110" "3" "1" "1" "1" "475" "54.8" "4.91" "4.12" "1" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04180" "84946" "ENSG00000135521" "LTV1" "hsa:84946; Q96GA3; Q96JX8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.933" "1.067" "1.014" "1.109" "0.831" "1.091" "0.869" "0.911" "2.820" "201.3" "187.8" "214.8" "204.1" "223.2" "167.3" "219.6" "174.8" "183.3" "567.7" "" "" "" "" "" "" "" "" "" "" "178.5" "155.5" "187.4" "152.7" "186.1" "153.7" "185.6" "144.5" "168.1" "567.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6886594892760411930" "False" "High" "IsMasterProtein" "Q13946" "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A OS=Homo sapiens OX=9606 GN=PDE7A PE=1 SV=2" "0.000" "False" "7.108" "4" "2" "3" "2" "482" "55.5" "7.50" "8.60" "2" "other metabolic processes;signal transduction" "cytosol" "other molecular function" "Pf00233" "5150" "ENSG00000205268" "PDE7A" "A0AVH6; A8K436; A8K9G5; hsa:5150; O15380; Q13946; Q96T72" "G alpha (s) signalling events" "Ectoderm differentiation; Ectoderm differentiation; G protein signaling pathways; Phosphodiesterases in neuronal function" "5" "0" "1.040" "1.184" "1.166" "1.178" "1.182" "1.068" "1.118" "1.373" "0.826" "167.9" "174.6" "198.8" "195.8" "197.8" "198.4" "179.3" "187.8" "230.4" "138.6" "" "" "" "" "" "" "" "" "" "" "148.9" "144.6" "173.5" "146.4" "164.9" "182.2" "151.5" "155.2" "211.3" "138.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2969987479368307007" "False" "High" "IsMasterProtein" "O14657" "Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2" "0.000" "False" "7.103" "3" "1" "1" "1" "336" "38.0" "8.54" "3.65" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "27348" "ENSG00000136816" "TOR1B" "hsa:27348; O14657" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119183533352449248" "False" "High" "IsMasterProtein" "Q9P0P8" "Mitochondrial transcription rescue factor 1 OS=Homo sapiens OX=9606 GN=MTRES1 PE=1 SV=1" "0.000" "False" "7.092" "9" "3" "3" "3" "240" "27.9" "9.29" "9.68" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "" "51250" "ENSG00000130349" "MTRES1" "B3KRG9; hsa:51250; Q9P0P8" "" "" "0" "0" "1.005" "1.136" "0.975" "0.933" "1.003" "1.116" "1.018" "1.026" "1.493" "85.2" "85.6" "96.8" "83.1" "79.5" "85.4" "95.1" "86.7" "87.4" "127.2" "" "" "" "" "" "" "" "" "" "" "75.6" "70.9" "84.5" "62.1" "66.3" "78.5" "80.4" "71.7" "80.2" "127.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8770420070751581353" "False" "High" "IsMasterProtein" "Q16718" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Homo sapiens OX=9606 GN=NDUFA5 PE=1 SV=3" "0.000" "False" "7.089" "14" "1" "1" "1" "116" "13.5" "5.99" "5.39" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf04716" "4698" "ENSG00000128609" "NDUFA5" "B2RD98; hsa:4698; Q16718; Q5H9R2; Q6IRX7" "RHOG GTPase cycle; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "1.010" "0.968" "1.217" "1.102" "0.978" "1.277" "1.182" "1.112" "0.691" "49.3" "49.8" "47.8" "60.0" "54.4" "48.2" "63.0" "58.3" "54.9" "34.1" "" "" "" "" "" "" "" "" "" "" "43.7" "41.3" "41.7" "44.9" "45.3" "44.3" "53.2" "48.2" "50.3" "34.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8588512168019091393" "False" "High" "IsMasterProtein" "Q5FWF5" "N-acetyltransferase ESCO1 OS=Homo sapiens OX=9606 GN=ESCO1 PE=1 SV=3" "0.000" "False" "7.089" "2" "2" "2" "2" "840" "94.9" "9.16" "5.66" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13878, Pf13880" "114799" "ENSG00000141446" "ESCO1" "B0YJ11; B0YJ12; hsa:114799; Q5FWF5; Q69YG4; Q69YS3; Q6IMD7; Q8N3Z5; Q8NBG2; Q96PX7" "Establishment of Sister Chromatid Cohesion" "Cohesin complex - Cornelia de Lange syndrome" "2" "0" "1.090" "0.890" "0.764" "1.019" "1.045" "0.727" "0.883" "0.921" "2.702" "16.9" "18.4" "15.0" "12.9" "17.2" "17.6" "12.3" "14.9" "15.5" "45.5" "" "" "" "" "" "" "" "" "" "" "14.9" "15.2" "13.1" "9.6" "14.3" "16.2" "10.4" "12.3" "14.2" "45.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5572152547917971737" "False" "High" "IsMasterProtein" "Q5T3J3" "Ligand-dependent nuclear receptor-interacting factor 1 OS=Homo sapiens OX=9606 GN=LRIF1 PE=1 SV=1" "0.000" "False" "7.070" "4" "2" "2" "2" "769" "84.5" "9.72" "6.71" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf15741" "55791" "ENSG00000121931" "LRIF1" "hsa:55791; Q5T3J3; Q86XS4; Q8N3B6; Q96HT4; Q9NUM5; Q9NV32" "" "" "0" "0" "0.962" "0.965" "0.954" "0.939" "0.935" "0.768" "0.834" "0.810" "0.572" "255.8" "246.1" "247.0" "244.1" "240.3" "239.1" "196.4" "213.3" "207.3" "146.5" "" "" "" "" "" "" "" "" "" "" "226.9" "203.9" "215.5" "182.5" "200.3" "219.6" "166.0" "176.3" "190.1" "146.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "High" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.000" "False" "7.069" "2" "1" "1" "1" "614" "67.1" "8.92" "4.92" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "HATs acetylate histones" "" "1" "0" "1.089" "1.029" "1.161" "1.022" "1.029" "0.959" "0.906" "1.115" "1.323" "82.4" "89.8" "84.8" "95.8" "84.3" "84.9" "79.0" "74.7" "92.0" "109.0" "" "" "" "" "" "" "" "" "" "" "73.1" "74.4" "74.0" "71.6" "70.3" "77.9" "66.8" "61.7" "84.3" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7667124068451477843" "False" "High" "IsMasterProtein" "P04035" "3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Homo sapiens OX=9606 GN=HMGCR PE=1 SV=1" "0.000" "False" "7.060" "2" "2" "3" "2" "888" "97.4" "6.74" "8.15" "2" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00368, Pf12349" "3156" "ENSG00000113161" "HMGCR" "B7Z3Y9; hsa:3156; P04035; Q8N190" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4894855171971746677" "False" "High" "IsMasterProtein" "Q7Z6G8" "Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ANKS1B PE=1 SV=2" "0.000" "False" "7.035" "1" "1" "1" "1" "1248" "138.0" "6.37" "2.86" "1" "signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00536, Pf00640, Pf12796" "56899" "ENSG00000185046" "ANKS1B" "A5PKY5; A7E259; A8K153; A8MSN4; B4DFP6; B4DH98; F8VPM3; F8VZR9; F8WC27; hsa:56899; Q5XLJ0; Q6IVB5; Q6NUS4; Q7Z6G6; Q7Z6G7; Q7Z6G8; Q8TAP3; Q9NRX7; Q9Y5K9" "" "Ectoderm differentiation" "1" "0" "1.179" "0.959" "0.613" "0.823" "0.991" "0.686" "0.350" "0.831" "7.875" "36.9" "43.5" "35.4" "22.6" "30.4" "36.5" "25.3" "12.9" "30.7" "290.6" "" "" "" "" "" "" "" "" "" "" "32.7" "36.0" "30.9" "16.9" "25.3" "33.6" "21.4" "10.7" "28.1" "290.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1438891196455375570" "False" "High" "IsMasterProtein" "A9UHW6" "MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1" "0.000" "False" "7.029" "10" "2" "2" "2" "222" "25.4" "5.33" "8.08" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854" "57409" "ENSG00000125457" "MIF4GD" "A9UHW6; B4DUM7; hsa:57409; Q8N4Q5; Q9HBL5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2450286954911087625" "False" "High" "IsMasterProtein" "O43325" "LYR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=LYRM1 PE=1 SV=1" "0.000" "False" "7.025" "14" "2" "2" "2" "122" "14.3" "9.94" "7.33" "2" "" "nucleus;other cell component" "" "Pf05347" "57149" "ENSG00000102897" "LYRM1" "B2R4M5; hsa:57149; O43325" "" "" "0" "0" "1.061" "1.086" "1.160" "1.022" "1.121" "1.179" "0.989" "1.035" "0.580" "319.7" "339.3" "347.3" "370.8" "326.8" "358.3" "376.9" "316.1" "330.9" "185.5" "" "" "" "" "" "" "" "" "" "" "283.5" "281.1" "303.1" "277.3" "272.5" "329.1" "318.5" "261.3" "303.5" "185.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172177916429743793" "False" "High" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "0.000" "False" "7.024" "4" "2" "2" "2" "390" "43.9" "6.46" "7.07" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "7" "0" "1.048" "0.941" "1.209" "1.046" "1.097" "0.991" "0.851" "0.847" "1.830" "67.8" "71.0" "63.8" "81.9" "70.9" "74.3" "67.1" "57.7" "57.4" "124.0" "" "" "" "" "" "" "" "" "" "" "60.1" "58.8" "55.6" "61.3" "59.1" "68.3" "56.8" "47.7" "52.6" "124.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "7.003" "6" "3" "3" "3" "417" "44.9" "8.75" "8.99" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "Neutrophil degranulation" "" "1" "0" "0.975" "1.079" "0.887" "1.058" "0.962" "0.892" "1.092" "1.023" "0.724" "47.0" "45.8" "50.7" "41.6" "49.7" "45.2" "41.9" "51.3" "48.1" "34.0" "" "" "" "" "" "" "" "" "" "" "41.7" "37.9" "44.2" "31.1" "41.4" "41.5" "35.4" "42.4" "44.1" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7086888772498369272" "False" "High" "IsMasterProtein" "Q15596" "Nuclear receptor coactivator 2 OS=Homo sapiens OX=9606 GN=NCOA2 PE=1 SV=2" "0.000" "False" "6.999" "1" "2" "2" "1" "1464" "159.1" "6.64" "6.95" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "10499" "ENSG00000140396" "NCOA2" "hsa:10499; Q14CD2; Q15596" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; SUMOylation of transcription cofactors; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; HATs acetylate histones; Recycling of bile acids and salts; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RORA activates gene expression; Synthesis of bile acids and bile salts via 27-hydroxycholesterol" "Androgen receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "25" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1106391379852214598" "False" "High" "IsMasterProtein" "Q8NAG6" "Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKLE1 PE=1 SV=2" "0.000" "False" "6.997" "2" "1" "1" "1" "615" "66.8" "6.43" "4.13" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796" "126549" "ENSG00000160117" "ANKLE1" "A8VU82; hsa:126549; Q8N8J8; Q8NAG6" "" "" "0" "0" "1.217" "1.079" "1.209" "1.090" "1.111" "0.892" "1.012" "1.132" "2.892" "136.0" "165.5" "146.8" "164.4" "148.2" "151.1" "121.3" "137.6" "153.9" "393.3" "" "" "" "" "" "" "" "" "" "" "120.6" "137.1" "128.1" "123.0" "123.6" "138.8" "102.5" "113.8" "141.2" "393.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4439599527071011873" "False" "High" "IsMasterProtein" "P15529" "Membrane cofactor protein OS=Homo sapiens OX=9606 GN=CD46 PE=1 SV=3" "0.000" "False" "6.992" "4" "2" "2" "2" "392" "43.7" "6.74" "6.92" "2" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00084" "4179" "ENSG00000117335" "CD46" "A0T1T0; A0T1T1; A0T1T2; hsa:4179; P15529; Q15429; Q53GV9; Q5HY94; Q5VWS6; Q5VWS7; Q5VWS8; Q5VWS9; Q5VWT0; Q5VWT1; Q5VWT2; Q6N0A1; Q7Z3R5; Q9NNW2; Q9NNW3; Q9NNW4; Q9UCJ4" "Regulation of Complement cascade" "Complement system; Dengue-2 interactions with complement and coagulation cascades; Measles virus infection; Complement system in neuronal development and plasticity; Complement and coagulation cascades" "6" "0" "0.953" "0.898" "1.025" "1.019" "0.994" "1.042" "1.024" "1.126" "0.723" "384.5" "366.5" "345.4" "394.0" "391.8" "382.3" "400.7" "393.7" "433.0" "278.0" "" "" "" "" "" "" "" "" "" "" "341.0" "303.6" "301.4" "294.7" "326.7" "351.2" "338.7" "325.4" "397.1" "278.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3359501381423715522" "False" "High" "IsMasterProtein" "A0A0A0MRZ8" "Immunoglobulin kappa variable 3D-11 OS=Homo sapiens OX=9606 GN=IGKV3D-11 PE=3 SV=6" "0.000" "False" "6.992" "8" "1" "2" "1" "115" "12.6" "5.29" "6.36" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "" "Pf07686" "" "ENSG00000211632" "IGKV3D-11" "A0A0A0MRZ8" "" "" "0" "0" "0.952" "1.010" "0.886" "1.027" "0.976" "0.805" "0.799" "0.732" "1.147" "116.6" "111.0" "117.8" "103.3" "119.8" "113.8" "93.8" "93.1" "85.3" "133.7" "" "" "" "" "" "" "" "" "" "" "103.4" "91.9" "102.8" "77.2" "99.9" "104.5" "79.3" "77.0" "78.3" "133.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9054842598653444166" "False" "High" "IsMasterProtein" "P16520" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 OS=Homo sapiens OX=9606 GN=GNB3 PE=1 SV=1" "0.000" "False" "6.964" "8" "3" "3" "1" "340" "37.2" "5.67" "7.12" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "2784" "ENSG00000111664" "GNB3" "hsa:2784; P16520; Q96B71; Q9BQC0" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "39" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2039087024744643374" "False" "High" "IsMasterProtein" "Cont_Q5D862" "Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1" "0.000" "True" "6.957" "4" "3" "3" "3" "2391" "247.9" "8.31" "7.54" "3" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other cell component" "other molecular function" "Pf01023" "388698" "ENSG00000143520" "FLG2" "hsa:388698; Q5D862; Q9H4U1" "Neutrophil degranulation" "" "1" "0" "1.067" "0.933" "1.360" "1.421" "1.845" "0.856" "0.944" "1.415" "1.414" "56.7" "60.6" "53.0" "77.1" "80.6" "104.7" "48.6" "53.6" "80.3" "80.2" "" "" "" "" "" "" "" "" "" "" "50.3" "50.2" "46.2" "57.7" "67.2" "96.1" "41.0" "44.3" "73.6" "80.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3175328810645519172" "False" "High" "IsMasterProtein" "Q6PH81" "UPF0547 protein C16orf87 OS=Homo sapiens OX=9606 GN=C16orf87 PE=1 SV=1" "0.000" "False" "6.938" "9" "1" "1" "1" "154" "17.8" "10.07" "4.18" "1" "" "" "" "Pf10571" "388272" "ENSG00000155330" "C16orf87" "Q63HN9; Q6PH81" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4361926129006051556" "False" "High" "IsMasterProtein" "Q9BSH4" "Translational activator of cytochrome c oxidase 1 OS=Homo sapiens OX=9606 GN=TACO1 PE=1 SV=1" "0.000" "False" "6.933" "7" "2" "2" "2" "297" "32.5" "8.13" "7.38" "2" "cell organization and biogenesis;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf01709, Pf20772" "51204" "ENSG00000136463" "TACO1" "B2RD21; hsa:51204; Q8N3N6; Q9BSH4; Q9UI60" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Mitochondrial complex IV assembly" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1490938523091261989" "False" "High" "IsMasterProtein" "O60292" "Signal-induced proliferation-associated 1-like protein 3 OS=Homo sapiens OX=9606 GN=SIPA1L3 PE=1 SV=3" "0.000" "False" "6.931" "1" "2" "2" "2" "1781" "194.5" "8.32" "7.09" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "23094" "ENSG00000105738" "SIPA1L3" "hsa:23094; O60292; Q2TV87" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "High" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.000" "False" "6.929" "7" "3" "3" "3" "423" "48.1" "8.59" "9.25" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.930" "0.917" "0.953" "1.065" "0.875" "1.104" "0.928" "1.104" "1.564" "85.9" "79.9" "78.8" "81.9" "91.5" "75.2" "94.9" "79.8" "94.9" "134.4" "" "" "" "" "" "" "" "" "" "" "76.2" "66.2" "68.8" "61.3" "76.3" "69.1" "80.2" "65.9" "87.0" "134.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3651526396460300245" "False" "High" "IsMasterProtein" "P17693" "HLA class I histocompatibility antigen, alpha chain G OS=Homo sapiens OX=9606 GN=HLA-G PE=1 SV=1" "0.000" "False" "6.925" "5" "2" "2" "1" "338" "38.2" "5.69" "6.12" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf07654" "3135" "ENSG00000204632; ENSG00000206506; ENSG00000230413; ENSG00000233095; ENSG00000235346; ENSG00000235680; ENSG00000237216; ENSG00000276051" "HLA-G" "hsa:3135; P17693" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7784023466259841542" "False" "High" "IsMasterProtein" "B0I1T2" "Unconventional myosin-Ig OS=Homo sapiens OX=9606 GN=MYO1G PE=1 SV=2" "0.000" "False" "6.917" "2" "2" "2" "2" "1018" "116.4" "8.73" "6.25" "2" "cell adhesion;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf06017" "64005" "ENSG00000136286" "MYO1G" "B0I1T2; hsa:64005; Q8TEI9; Q8TES2; Q96BE2; Q96RI5; Q96RI6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9046713427756662077" "False" "High" "IsMasterProtein" "Q05209" "Tyrosine-protein phosphatase non-receptor type 12 OS=Homo sapiens OX=9606 GN=PTPN12 PE=1 SV=3" "0.000" "False" "6.909" "1" "1" "1" "1" "780" "88.1" "5.62" "4.22" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5782" "ENSG00000127947" "PTPN12" "A4D1C5; B4DKY2; E9PBR5; E9PEH9; hsa:5782; Q05209; Q16130; Q59FD6; Q75MN8; Q86XU4" "Signaling by PDGF; SHC1 events in ERBB2 signaling; Downregulation of ERBB2 signaling; EGFR downregulation; Interleukin-37 signaling; Constitutive Signaling by Overexpressed ERBB2" "EGF/EGFR signaling pathway" "7" "0" "1.069" "0.854" "1.161" "1.019" "1.032" "1.054" "0.805" "1.059" "2.352" "87.4" "93.4" "74.6" "101.5" "89.1" "90.2" "92.1" "70.4" "92.5" "205.6" "" "" "" "" "" "" "" "" "" "" "77.5" "77.4" "65.1" "75.9" "74.3" "82.8" "77.8" "58.2" "84.9" "205.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1109388387442681582" "False" "High" "IsMasterProtein" "Q9BWU1" "Cyclin-dependent kinase 19 OS=Homo sapiens OX=9606 GN=CDK19 PE=1 SV=1" "0.000" "False" "6.905" "6" "3" "3" "1" "502" "56.8" "8.53" "8.05" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "23097" "ENSG00000155111" "CDK19" "hsa:23097; Q5JQZ7; Q5JR00; Q8TC78; Q9BWU1; Q9UPX2" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3561433586626158640" "False" "High" "IsMasterProtein" "Q7Z5L2" "Coiled-coil domain-containing protein R3HCC1L OS=Homo sapiens OX=9606 GN=R3HCC1L PE=1 SV=3" "0.000" "False" "6.905" "2" "2" "2" "2" "792" "87.8" "5.16" "5.91" "2" "" "" "" "" "27291" "ENSG00000166024" "R3HCC1L" "hsa:27291; O60598; Q5W0B4; Q5W0B5; Q7Z5L2; Q86VT9; Q8N9H0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7849372490440627698" "False" "High" "IsMasterProtein" "Q96P16" "Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1" "0.000" "False" "6.903" "4" "1" "1" "1" "312" "35.7" "7.55" "4.19" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "55197" "ENSG00000141425" "RPRD1A" "A8KA42; B2RBA3; hsa:55197; Q7Z5G8; Q96FY9; Q96P16; Q9NVL4" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.124" "1.206" "0.978" "1.132" "0.998" "1.147" "0.818" "1.236" "9.159" "38.6" "43.4" "46.5" "37.8" "43.7" "38.5" "44.3" "31.6" "47.7" "353.4" "" "" "" "" "" "" "" "" "" "" "34.2" "35.9" "40.6" "28.2" "36.4" "35.4" "37.4" "26.1" "43.8" "353.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4261642457935236614" "False" "High" "IsMasterProtein" "Q9NS73" "MAP3K12-binding inhibitory protein 1 OS=Homo sapiens OX=9606 GN=MBIP PE=1 SV=2" "0.000" "False" "6.901" "6" "2" "2" "2" "344" "39.3" "7.24" "5.40" "2" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "51562" "ENSG00000151332" "MBIP" "hsa:51562; Q86TZ2; Q96AS5; Q9BS93; Q9NS73; Q9NZE1" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "1.223" "0.941" "0.986" "1.090" "1.004" "1.060" "0.475" "1.115" "7.102" "19.4" "23.7" "18.3" "19.1" "21.2" "19.5" "20.6" "9.2" "21.6" "137.9" "" "" "" "" "" "" "" "" "" "" "17.2" "19.7" "15.9" "14.3" "17.6" "17.9" "17.4" "7.6" "19.9" "137.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6665492664209257681" "False" "High" "IsMasterProtein" "Q6P1Q9" "tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3" "0.000" "False" "6.894" "6" "3" "3" "3" "378" "43.4" "5.86" "9.22" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf08242" "55798" "ENSG00000165055" "METTL2B" "B4DZ68; hsa:55798; Q0IJ54; Q3B7J1; Q6P1Q9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9039858235339298469" "False" "High" "IsMasterProtein" "Q92805" "Golgin subfamily A member 1 OS=Homo sapiens OX=9606 GN=GOLGA1 PE=1 SV=3" "0.000" "False" "6.893" "4" "3" "3" "3" "767" "88.1" "5.27" "5.90" "3" "" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf01465" "2800" "ENSG00000136935" "GOLGA1" "hsa:2800; Q5T164; Q8IYZ9; Q92805" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4003826422992493976" "False" "High" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "0.000" "False" "6.892" "18" "2" "2" "2" "163" "17.7" "5.19" "6.31" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "3" "0" "1.102" "0.888" "0.962" "1.030" "1.019" "1.092" "0.976" "1.013" "3.820" "68.8" "75.8" "61.1" "66.2" "70.9" "70.1" "75.2" "67.1" "69.7" "262.9" "" "" "" "" "" "" "" "" "" "" "61.0" "62.8" "53.3" "49.5" "59.1" "64.4" "63.5" "55.5" "63.9" "262.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "786541619406263347" "False" "High" "IsMasterProtein" "O95243" "Methyl-CpG-binding domain protein 4 OS=Homo sapiens OX=9606 GN=MBD4 PE=1 SV=1" "0.000" "False" "6.883" "2" "1" "2" "1" "580" "66.0" "8.82" "9.55" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01429" "8930" "ENSG00000129071" "MBD4" "B4DZN2; D3DNC3; D3DNC4; E9PEE4; hsa:8930; O95243; Q2MD36; Q7Z4T3; Q96F09" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1" "Base excision repair; DNA repair pathways, full network" "5" "0" "0.987" "0.960" "0.973" "0.966" "0.912" "0.906" "0.853" "0.890" "1.259" "409.4" "404.2" "393.1" "398.5" "395.6" "373.3" "370.8" "349.3" "364.6" "515.6" "" "" "" "" "" "" "" "" "" "" "363.1" "334.8" "343.0" "298.0" "329.9" "343.0" "313.3" "288.7" "334.4" "515.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746729675254705765" "False" "High" "IsMasterProtein" "Q6ZN18" "Zinc finger protein AEBP2 OS=Homo sapiens OX=9606 GN=AEBP2 PE=1 SV=2" "0.000" "False" "6.872" "7" "3" "3" "3" "517" "54.4" "5.21" "5.87" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "121536" "ENSG00000139154" "AEBP2" "hsa:121536; Q59FS5; Q6ZN18; Q6ZN62; Q96BG3" "PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "Histone modifications; Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2)" "5" "0" "0.944" "1.016" "1.006" "0.963" "0.997" "1.052" "0.969" "0.922" "1.267" "725.4" "684.9" "737.0" "730.1" "698.7" "723.2" "762.9" "703.3" "668.9" "919.1" "" "" "" "" "" "" "" "" "" "" "643.3" "567.4" "643.1" "546.0" "582.6" "664.3" "644.8" "581.3" "613.5" "919.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7004216377696589077" "False" "High" "IsMasterProtein" "Q96DC7" "Transmembrane and coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=TMCO6 PE=1 SV=2" "0.000" "False" "6.866" "2" "1" "1" "1" "493" "54.4" "5.81" "4.44" "1" "transport" "other membranes" "other molecular function" "" "55374" "ENSG00000113119" "TMCO6" "hsa:55374; Q96DC7; Q9BUU0; Q9P198" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "High" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.000" "False" "6.848" "1" "2" "2" "1" "2514" "273.5" "7.59" "6.11" "2" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of transcription cofactors; HDACs deacetylate histones; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "23" "0" "0.970" "0.857" "0.872" "0.731" "0.903" "0.796" "0.770" "0.854" "1.310" "53.4" "51.8" "45.8" "46.6" "39.1" "48.2" "42.5" "41.1" "45.6" "70.0" "" "" "" "" "" "" "" "" "" "" "47.4" "42.9" "39.9" "34.8" "32.6" "44.3" "35.9" "34.0" "41.8" "70.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8660233523405071508" "False" "High" "IsMasterProtein" "A0FGR8" "Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1" "0.000" "False" "6.828" "1" "1" "1" "1" "921" "102.3" "9.26" "3.55" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00168, Pf17047" "57488" "ENSG00000117868" "ESYT2" "A0FGR8; A4D229; hsa:57488; Q69YJ2; Q6UKI4; Q6ZTU0; Q6ZVU1; Q9BQS0; Q9NW47; Q9ULJ2" "Glycosphingolipid transport" "" "1" "0" "1.002" "1.067" "0.966" "1.062" "0.993" "1.133" "0.996" "1.056" "0.744" "48.5" "48.6" "51.8" "46.9" "51.5" "48.2" "55.0" "48.3" "51.3" "36.1" "" "" "" "" "" "" "" "" "" "" "43.0" "40.3" "45.2" "35.1" "43.0" "44.3" "46.5" "40.0" "47.0" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4731047404195791293" "False" "High" "IsMasterProtein" "Q8IXW5" "Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 OS=Homo sapiens OX=9606 GN=RPAP2 PE=1 SV=1" "0.000" "False" "6.824" "4" "2" "2" "2" "612" "69.5" "7.78" "3.87" "2" "RNA metabolism OR transcription;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04181" "79871" "ENSG00000122484" "RPAP2" "C9JKB5; hsa:79871; Q49AS7; Q8IXW5; Q9H8Y2" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.914" "0.795" "0.845" "0.844" "0.909" "0.843" "0.647" "0.941" "4.870" "64.0" "58.4" "50.9" "54.1" "54.0" "58.1" "53.9" "41.4" "60.2" "311.5" "" "" "" "" "" "" "" "" "" "" "56.7" "48.4" "44.4" "40.4" "45.0" "53.4" "45.6" "34.2" "55.2" "311.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3715584417028259664" "False" "High" "IsMasterProtein" "P56381" "ATP synthase subunit epsilon, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1E PE=1 SV=2" "0.000" "False" "6.820" "43" "3" "6" "3" "51" "5.8" "9.92" "17.05" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "514" "ENSG00000124172" "ATP5F1E" "B2RDD0; E1P5H6; hsa:514; P56381; Q53XU6" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "1.065" "1.137" "0.981" "1.074" "1.219" "1.030" "1.068" "1.054" "0.548" "1013.0" "1078.9" "1151.5" "993.3" "1088.5" "1234.5" "1043.5" "1082.1" "1067.9" "555.2" "" "" "" "" "" "" "" "" "" "" "898.3" "893.7" "1004.7" "742.9" "907.6" "1134.0" "881.9" "894.4" "979.4" "555.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7308711199030270349" "False" "High" "IsMasterProtein" "A6ND36" "Protein FAM83G OS=Homo sapiens OX=9606 GN=FAM83G PE=1 SV=2" "0.000" "False" "6.816" "2" "2" "2" "2" "823" "90.8" "6.39" "6.61" "2" "signal transduction" "cytosol;nucleus" "other molecular function" "Pf07894" "644815" "ENSG00000188522" "FAM83G" "A6ND36; hsa:644815; Q3KQZ4; Q6ZW60" "" "" "0" "0" "1.023" "0.994" "1.112" "0.897" "1.049" "0.995" "0.998" "1.097" "1.872" "135.0" "138.1" "134.2" "150.2" "121.1" "141.6" "134.4" "134.8" "148.2" "252.8" "" "" "" "" "" "" "" "" "" "" "119.7" "114.4" "117.1" "112.3" "100.9" "130.1" "113.6" "111.4" "135.9" "252.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2965496322835630432" "False" "High" "IsMasterProtein" "Q9NYM9" "BET1-like protein OS=Homo sapiens OX=9606 GN=BET1L PE=1 SV=1" "0.000" "False" "6.796" "12" "1" "1" "1" "111" "12.4" "8.16" "4.17" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "" "51272" "ENSG00000177951" "BET1L" "B3KMY0; hsa:51272; Q9NYM9" "COPI-mediated anterograde transport; Intra-Golgi traffic" "" "2" "0" "1.085" "0.956" "1.157" "1.024" "1.047" "1.109" "1.043" "0.996" "0.792" "148.7" "161.2" "142.1" "171.9" "152.2" "155.6" "164.8" "155.0" "148.1" "117.7" "" "" "" "" "" "" "" "" "" "" "131.8" "133.6" "124.0" "128.6" "126.9" "142.9" "139.3" "128.1" "135.8" "117.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3586034237824916844" "False" "High" "IsMasterProtein" "P11117" "Lysosomal acid phosphatase OS=Homo sapiens OX=9606 GN=ACP2 PE=1 SV=3" "0.000" "False" "6.778" "6" "3" "3" "3" "423" "48.3" "6.74" "6.60" "3" "cell organization and biogenesis;other metabolic processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00328" "53" "ENSG00000134575" "ACP2" "E9PCI1; hsa:53; P11117; Q561W5; Q9BTU7" "" "" "0" "0" "0.998" "1.054" "0.825" "1.081" "1.266" "1.138" "1.080" "1.388" "0.523" "53.4" "53.3" "56.3" "44.1" "57.8" "67.7" "60.8" "57.7" "74.2" "28.0" "" "" "" "" "" "" "" "" "" "" "47.4" "44.2" "49.2" "33.0" "48.2" "62.2" "51.4" "47.7" "68.0" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146278248105171304" "False" "High" "IsMasterProtein" "Q6SJ93" "Serine protease FAM111B OS=Homo sapiens OX=9606 GN=FAM111B PE=1 SV=1" "0.000" "False" "6.776" "3" "2" "2" "2" "734" "84.6" "8.59" "7.71" "2" "protein metabolism;DNA metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf13365" "374393" "ENSG00000189057" "FAM111B" "B4E2G2; hsa:374393; Q6P661; Q6SJ93" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6321776130452368548" "False" "High" "IsMasterProtein" "Q9H7Z6" "Histone acetyltransferase KAT8 OS=Homo sapiens OX=9606 GN=KAT8 PE=1 SV=2" "0.000" "False" "6.774" "5" "2" "2" "2" "458" "52.4" "8.27" "7.46" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "84148" "ENSG00000103510" "KAT8" "A8K4Z1; G5E9P2; hsa:84148; Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9H7Z6; Q9HAC5; Q9NR35" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "" "2" "0" "0.904" "0.909" "0.831" "0.861" "0.912" "0.752" "0.787" "0.877" "1.730" "171.2" "154.7" "155.6" "142.3" "147.3" "156.1" "128.7" "134.7" "150.0" "296.1" "" "" "" "" "" "" "" "" "" "" "151.8" "128.2" "135.7" "106.4" "122.8" "143.4" "108.8" "111.4" "137.6" "296.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716133539155154712" "False" "High" "IsMasterProtein" "P82650" "Small ribosomal subunit protein mS22 OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "0.000" "False" "6.768" "5" "2" "2" "2" "360" "41.3" "7.90" "7.47" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Primary ovarian insufficiency" "4" "0" "1.006" "0.972" "1.038" "1.006" "0.976" "1.006" "0.710" "1.002" "4.423" "168.8" "169.8" "164.1" "175.3" "169.8" "164.7" "169.8" "119.9" "169.2" "746.8" "" "" "" "" "" "" "" "" "" "" "149.7" "140.7" "143.2" "131.1" "141.6" "151.3" "143.5" "99.1" "155.1" "746.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719462215085106760" "False" "High" "IsMasterProtein" "Q8N983" "Large ribosomal subunit protein mL43 OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" "0.000" "False" "6.764" "12" "3" "3" "3" "215" "23.4" "8.65" "6.94" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "84545" "ENSG00000055950" "MRPL43" "B1AL06; B1AL07; B1AL09; B1AL10; C9J5Q3; D3DR71; hsa:84545; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q8N983; Q9BYC7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731116703421718606" "False" "High" "IsMasterProtein" "Q53H80" "Akirin-2 OS=Homo sapiens OX=9606 GN=AKIRIN2 PE=1 SV=2" "0.000" "False" "6.755" "14" "3" "3" "3" "203" "22.5" "8.73" "5.49" "3" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "" "55122" "ENSG00000135334" "AKIRIN2" "hsa:55122; Q53H80; Q9BQB1" "" "" "0" "0" "0.813" "0.742" "1.013" "0.766" "0.961" "1.055" "0.977" "0.693" "0.592" "120.0" "97.5" "89.0" "121.5" "91.9" "115.3" "126.6" "117.2" "83.1" "71.1" "" "" "" "" "" "" "" "" "" "" "106.4" "80.8" "77.7" "90.9" "76.6" "106.0" "107.0" "96.9" "76.2" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4321447803487511562" "False" "High" "IsMasterProtein" "Q8NEZ2" "Vacuolar protein sorting-associated protein 37A OS=Homo sapiens OX=9606 GN=VPS37A PE=1 SV=1" "0.000" "False" "6.747" "5" "1" "1" "1" "397" "44.3" "5.57" "4.76" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf07200" "137492" "ENSG00000155975" "VPS37A" "hsa:137492; Q336D5; Q6NW27; Q8N3D7; Q8NEZ2; Q8TBL7; Q96DL9" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "7q11.23 copy number variation syndrome" "6" "0" "0.802" "1.035" "0.859" "1.029" "1.060" "0.711" "0.573" "0.764" "5.089" "25.2" "20.2" "26.1" "21.6" "25.9" "26.7" "17.9" "14.4" "19.2" "128.0" "" "" "" "" "" "" "" "" "" "" "22.3" "16.7" "22.7" "16.2" "21.6" "24.5" "15.1" "11.9" "17.6" "128.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4077783620514139312" "False" "High" "IsMasterProtein" "Q15650" "Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4" "0.000" "False" "6.735" "3" "2" "2" "2" "581" "66.1" "7.85" "5.62" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04266, Pf06221" "9325" "ENSG00000103671" "TRIP4" "B2RAS0; hsa:9325; Q15650; Q96ED7; Q9UKH0" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.044" "1.427" "0.871" "1.090" "1.164" "0.771" "1.199" "1.426" "0.997" "33.8" "35.3" "48.2" "29.4" "36.8" "39.3" "26.1" "40.5" "48.2" "33.7" "" "" "" "" "" "" "" "" "" "" "30.0" "29.2" "42.1" "22.0" "30.7" "36.1" "22.0" "33.5" "44.2" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8872418037025781977" "False" "High" "IsMasterProtein" "Q5VTB9" "E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens OX=9606 GN=RNF220 PE=1 SV=1" "0.000" "False" "6.723" "2" "1" "1" "1" "566" "62.7" "6.04" "4.22" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf15926" "55182" "ENSG00000187147" "RNF220" "B3KPJ3; B4DLZ9; E9PCS1; hsa:55182; Q4KMX2; Q5VTB9; Q9NVP6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3369137616140023088" "False" "High" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "0.000" "False" "6.719" "12" "2" "2" "1" "180" "20.3" "6.35" "6.39" "2" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "1.048" "0.844" "1.089" "1.124" "0.988" "1.134" "0.903" "0.898" "2.114" "79.6" "83.4" "67.2" "86.6" "89.4" "78.6" "90.2" "71.9" "71.5" "168.2" "" "" "" "" "" "" "" "" "" "" "70.6" "69.1" "58.6" "64.8" "74.5" "72.2" "76.2" "59.4" "65.5" "168.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7526904377414410620" "False" "High" "IsMasterProtein" "Q6NXR4" "TELO2-interacting protein 2 OS=Homo sapiens OX=9606 GN=TTI2 PE=1 SV=1" "0.000" "False" "6.706" "3" "1" "1" "1" "508" "56.9" "7.09" "4.64" "1" "other biological processes" "nucleus;other cell component" "" "Pf10521" "80185" "ENSG00000129696" "TTI2" "D3DSV7; hsa:80185; Q6NXR4; Q96IM2; Q9H5N4" "" "" "0" "0" "0.960" "0.821" "0.990" "0.885" "0.836" "0.676" "0.492" "0.995" "9.717" "40.1" "38.5" "32.9" "39.7" "35.5" "33.5" "27.1" "19.7" "39.9" "389.6" "" "" "" "" "" "" "" "" "" "" "35.6" "31.9" "28.7" "29.7" "29.6" "30.8" "22.9" "16.3" "36.6" "389.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1854520312951704103" "False" "High" "IsMasterProtein" "Q7RTV3" "Zinc finger protein 367 OS=Homo sapiens OX=9606 GN=ZNF367 PE=1 SV=1" "0.000" "False" "6.691" "3" "1" "1" "1" "350" "38.4" "7.93" "4.43" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "195828" "ENSG00000165244" "ZNF367" "hsa:195828; Q6Q7C8; Q7RTV3" "" "" "0" "0" "0.873" "0.843" "0.949" "0.811" "0.806" "0.952" "0.925" "1.004" "1.855" "217.5" "189.9" "183.5" "206.4" "176.4" "175.4" "207.2" "201.2" "218.3" "403.5" "" "" "" "" "" "" "" "" "" "" "192.9" "157.3" "160.1" "154.3" "147.1" "161.1" "175.1" "166.3" "200.2" "403.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5787268108856466186" "False" "High" "IsMasterProtein" "O15198" "Mothers against decapentaplegic homolog 9 OS=Homo sapiens OX=9606 GN=SMAD9 PE=1 SV=1" "0.000" "False" "6.672" "4" "2" "4" "1" "467" "52.5" "7.77" "8.76" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4093" "ENSG00000120693" "SMAD9" "A2A2Y6; hsa:4093; O14989; O15198; Q5TBA1" "Signaling by BMP" "Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; Embryonic stem cell pluripotency pathways; Neovascularization processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Clock-controlled autophagy in bone metabolism; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling" "11" "0" "0.680" "0.648" "0.688" "0.590" "0.533" "0.637" "0.015" "0.574" "9.502" "55.2" "37.5" "35.8" "38.0" "32.6" "29.4" "35.2" "0.8" "31.7" "524.8" "" "" "" "" "" "" "" "" "" "" "49.0" "31.1" "31.2" "28.4" "27.2" "27.0" "29.8" "0.7" "29.1" "524.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3764290193644051117" "False" "High" "IsMasterProtein" "Q8WU10" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYROXD1 PE=1 SV=1" "0.000" "False" "6.661" "2" "1" "1" "1" "500" "55.8" "5.85" "4.24" "1" "stress response" "cytoskeleton;nucleus" "other molecular function" "Pf07992, Pf18267" "79912" "ENSG00000121350" "PYROXD1" "A6NKI6; B3KWN8; hsa:79912; Q8WU10; Q9H6P1" "" "" "0" "0" "1.082" "1.094" "0.961" "0.879" "1.168" "1.046" "0.848" "0.815" "2.748" "103.8" "112.2" "113.5" "99.7" "91.3" "121.2" "108.6" "88.0" "84.6" "285.2" "" "" "" "" "" "" "" "" "" "" "92.0" "93.0" "99.0" "74.6" "76.1" "111.4" "91.7" "72.7" "77.6" "285.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "6.658" "16" "3" "3" "3" "145" "17.2" "10.55" "9.65" "3" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.938" "0.921" "1.011" "0.976" "0.949" "0.989" "0.809" "0.785" "0.965" "426.4" "400.2" "392.6" "431.1" "416.2" "404.8" "421.8" "345.2" "334.9" "411.6" "" "" "" "" "" "" "" "" "" "" "378.1" "331.5" "342.5" "322.4" "347.0" "371.9" "356.5" "285.3" "307.2" "411.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463306019950863991" "False" "High" "IsMasterProtein" "O60784" "Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "0.000" "False" "6.657" "3" "2" "2" "2" "492" "53.8" "4.70" "6.81" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "Neutrophil degranulation" "" "1" "0" "1.035" "0.976" "0.980" "0.897" "0.952" "0.979" "0.926" "1.010" "1.670" "250.8" "259.6" "244.8" "245.7" "225.0" "238.7" "245.4" "232.3" "253.4" "418.7" "" "" "" "" "" "" "" "" "" "" "222.4" "215.1" "213.6" "183.8" "187.6" "219.2" "207.4" "192.0" "232.4" "418.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5259083941231079932" "False" "High" "IsMasterProtein" "Q7Z4G1" "COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1" "0.000" "False" "6.642" "24" "2" "3" "2" "85" "9.6" "6.00" "9.84" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07258" "170622" "ENSG00000188243" "COMMD6" "A6NF28; B7ZLN0; hsa:170622; Q5TBK4; Q7Z4G1" "Neddylation" "" "1" "0" "1.002" "0.890" "0.906" "0.969" "0.898" "0.957" "0.977" "0.973" "1.119" "91.1" "91.2" "81.1" "82.5" "88.2" "81.8" "87.2" "89.0" "88.6" "101.9" "" "" "" "" "" "" "" "" "" "" "80.8" "75.6" "70.7" "61.7" "73.6" "75.2" "73.7" "73.6" "81.3" "101.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1933221655195887303" "False" "High" "IsMasterProtein" "Q9ULX9" "Transcription factor MafF OS=Homo sapiens OX=9606 GN=MAFF PE=1 SV=2" "0.000" "False" "6.617" "14" "1" "1" "1" "164" "17.7" "9.80" "6.18" "1" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "23764" "ENSG00000185022" "MAFF" "B4DV49; hsa:23764; Q9ULX9; Q9Y525" "Factors involved in megakaryocyte development and platelet production" "Nuclear receptors meta-pathway; NRF2 pathway; Myometrial relaxation and contraction pathways; Ethanol metabolism production of ROS by CYP2E1; Orexin receptor pathway" "6" "0" "0.836" "0.956" "0.797" "0.872" "0.728" "0.861" "0.937" "0.933" "1.009" "36.4" "30.4" "34.8" "29.0" "31.7" "26.5" "31.3" "34.1" "33.9" "36.7" "" "" "" "" "" "" "" "" "" "" "32.3" "25.2" "30.3" "21.7" "26.5" "24.3" "26.5" "28.2" "31.1" "36.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527600213539074294" "False" "High" "IsMasterProtein" "O43291" "Kunitz-type protease inhibitor 2 OS=Homo sapiens OX=9606 GN=SPINT2 PE=1 SV=2" "0.000" "False" "6.612" "5" "1" "1" "1" "252" "28.2" "8.29" "4.07" "1" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00014" "10653" "ENSG00000167642" "SPINT2" "A8K667; B4DLU1; hsa:10653; O00271; O14895; O43291; Q5TZQ3; Q969E0" "MET Receptor Activation; Signaling by MST1" "" "2" "0" "0.786" "0.675" "0.785" "0.780" "0.890" "0.772" "0.878" "0.864" "0.930" "212.5" "167.0" "143.5" "166.9" "165.7" "189.2" "164.0" "186.7" "183.5" "197.6" "" "" "" "" "" "" "" "" "" "" "188.5" "138.3" "125.2" "124.8" "138.2" "173.8" "138.6" "154.3" "168.3" "197.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "631101565045639335" "False" "High" "IsMasterProtein" "Q8WUU4" "Zinc finger protein 296 OS=Homo sapiens OX=9606 GN=ZNF296 PE=1 SV=1" "0.000" "False" "6.590" "4" "2" "3" "2" "475" "50.8" "8.82" "8.77" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "162979" "ENSG00000170684" "ZNF296" "hsa:162979; Q8WUU4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7215456536450440199" "False" "High" "IsMasterProtein" "Q9H0U9" "Testis-specific Y-encoded-like protein 1 OS=Homo sapiens OX=9606 GN=TSPYL1 PE=1 SV=3" "0.000" "False" "6.589" "4" "1" "1" "1" "437" "49.2" "5.45" "4.43" "1" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "7259" "ENSG00000189241" "TSPYL1" "hsa:7259; O75885; Q5TFE6; Q9H0U9" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4390061241352575470" "False" "High" "IsMasterProtein" "Q9HC07" "Putative divalent cation/proton antiporter TMEM165 OS=Homo sapiens OX=9606 GN=TMEM165 PE=1 SV=1" "0.000" "False" "6.581" "6" "1" "1" "1" "324" "34.9" "7.02" "5.28" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01169" "55858" "ENSG00000134851" "TMEM165" "A8K3P8; B4DHW1; hsa:55858; Q9BTN9; Q9HC07; Q9NZ34" "" "IL-18 signaling pathway" "1" "0" "1.073" "0.906" "1.148" "1.057" "1.240" "1.255" "1.110" "1.196" "1.293" "64.2" "68.9" "58.2" "73.7" "67.9" "79.7" "80.7" "71.3" "76.9" "83.1" "" "" "" "" "" "" "" "" "" "" "57.0" "57.1" "50.8" "55.1" "56.6" "73.2" "68.2" "59.0" "70.5" "83.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1774783025886983785" "False" "High" "IsMasterProtein" "Q86TS9" "Large ribosomal subunit protein mL52 OS=Homo sapiens OX=9606 GN=MRPL52 PE=1 SV=2" "0.000" "False" "6.575" "20" "2" "2" "2" "123" "13.7" "10.26" "5.75" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf18699" "122704" "ENSG00000172590" "MRPL52" "A6NMQ8; A8MXK5; A8MYI6; G3XCN9; hsa:122704; Q6NVH8; Q86TS9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.091" "1.124" "1.208" "1.098" "1.179" "1.013" "0.982" "0.964" "0.562" "50.1" "54.6" "56.3" "60.5" "55.0" "59.1" "50.7" "49.2" "48.3" "28.1" "" "" "" "" "" "" "" "" "" "" "44.4" "45.3" "49.1" "45.3" "45.9" "54.3" "42.9" "40.7" "44.3" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "High" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.000" "False" "6.556" "0" "1" "5" "1" "1693" "189.1" "7.74" "14.20" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Synthesis of IP3 and IP4 in the cytosol" "Mesodermal commitment pathway; GPR40 pathway" "3" "0" "1.183" "1.091" "1.085" "1.176" "1.147" "1.184" "1.204" "1.041" "0.545" "539.8" "638.7" "588.9" "585.5" "634.7" "619.4" "639.3" "650.2" "562.2" "294.1" "" "" "" "" "" "" "" "" "" "" "478.7" "529.1" "513.8" "437.9" "529.2" "569.0" "540.3" "537.4" "515.6" "294.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2618859431670300252" "False" "High" "IsMasterProtein" "Q5VSG8" "Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Homo sapiens OX=9606 GN=MANEAL PE=1 SV=1" "0.000" "False" "6.548" "2" "1" "1" "1" "457" "51.3" "6.98" "5.91" "1" "" "other membranes;ER/Golgi" "other molecular function" "Pf16317" "149175" "ENSG00000185090" "MANEAL" "hsa:149175; Q5VSG8; Q6DD86; Q6P497; Q8N5P8; Q96G55; Q96N42" "" "" "0" "0" "0.770" "0.801" "0.685" "0.770" "0.656" "0.899" "0.872" "0.736" "0.570" "65.9" "50.7" "52.8" "45.1" "50.7" "43.3" "59.2" "57.5" "48.5" "37.5" "" "" "" "" "" "" "" "" "" "" "58.4" "42.0" "46.0" "33.8" "42.3" "39.7" "50.1" "47.5" "44.5" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "6.545" "3" "2" "2" "2" "582" "66.9" "9.55" "6.00" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "" "VEGFA-VEGFR2 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8959015413367013633" "False" "High" "IsMasterProtein" "Q6P589" "Tumor necrosis factor alpha-induced protein 8-like protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP8L2 PE=1 SV=1" "0.000" "False" "6.541" "10" "2" "3" "2" "184" "20.5" "8.44" "6.27" "2" "stress response;other biological processes" "nucleus;other cytoplasmic organelle;other cell component" "" "Pf05527" "79626" "ENSG00000163154" "TNFAIP8L2" "hsa:79626; Q6I9Y0; Q6P589; Q9H2H7; Q9H5G2" "PI Metabolism" "" "1" "0" "0.865" "0.927" "0.805" "0.849" "0.874" "0.776" "0.689" "0.846" "5.391" "162.9" "141.0" "151.0" "131.2" "138.3" "142.4" "126.4" "112.2" "137.8" "878.3" "" "" "" "" "" "" "" "" "" "" "144.5" "116.8" "131.7" "98.1" "115.4" "130.8" "106.9" "92.7" "126.4" "878.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1208810271641948454" "False" "High" "IsMasterProtein" "Q8NEL9" "Phospholipase DDHD1 OS=Homo sapiens OX=9606 GN=DDHD1 PE=1 SV=2" "0.000" "False" "6.534" "2" "2" "2" "2" "900" "100.4" "5.67" "5.83" "2" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02862" "80821" "ENSG00000100523" "DDHD1" "G5E9D1; hsa:80821; Q8NEL9; Q8WVH3; Q96LL2; Q9C0F8" "Synthesis of PA" "" "1" "0" "0.670" "0.770" "0.898" "0.465" "0.244" "0.469" "0.494" "0.912" "3.102" "34.8" "23.3" "26.8" "31.3" "16.2" "8.5" "16.3" "17.2" "31.7" "107.9" "" "" "" "" "" "" "" "" "" "" "30.9" "19.3" "23.4" "23.4" "13.5" "7.8" "13.8" "14.2" "29.1" "107.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938095953211403933" "False" "High" "IsMasterProtein" "P98164" "Low-density lipoprotein receptor-related protein 2 OS=Homo sapiens OX=9606 GN=LRP2 PE=1 SV=3" "0.000" "False" "6.527" "0" "1" "1" "1" "4655" "521.6" "5.08" "4.06" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670" "4036" "ENSG00000081479" "LRP2" "hsa:4036; O00711; P98164; Q16215" "Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; Transport of RCbl within the body; Vitamin D (calciferol) metabolism" "Vitamin B12 metabolism; Complement system; Hedgehog signaling pathway" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7381193083052724868" "False" "High" "IsMasterProtein" "Q9Y6R4" "Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2" "0.000" "False" "6.521" "2" "3" "3" "3" "1608" "181.6" "6.32" "8.54" "3" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf19431" "4216" "ENSG00000085511" "MAP3K4" "A6H8W0; B7ZLD3; B9EG75; hsa:4216; Q5VTT8; Q5VTT9; Q92612; Q9H408; Q9Y6R4" "" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)" "9" "0" "1.045" "0.964" "0.923" "0.997" "1.016" "1.108" "1.209" "1.158" "1.167" "320.0" "334.4" "308.5" "295.3" "319.1" "325.2" "354.5" "387.0" "370.7" "373.3" "" "" "" "" "" "" "" "" "" "" "283.7" "277.0" "269.1" "220.9" "266.1" "298.7" "299.6" "319.9" "340.0" "373.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4583007171926660229" "False" "High" "IsMasterProtein" "Q9H1I8" "Activating signal cointegrator 1 complex subunit 2 OS=Homo sapiens OX=9606 GN=ASCC2 PE=1 SV=3" "0.000" "False" "6.506" "2" "1" "2" "1" "757" "86.3" "5.16" "7.65" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf02845" "84164" "ENSG00000100325" "ASCC2" "B7Z8E0; F5H6J9; hsa:84164; Q4TT54; Q8TAZ0; Q9H1I8; Q9H711; Q9H9D6" "ALKBH3 mediated reversal of alkylation damage" "" "1" "0" "0.960" "0.940" "0.940" "0.950" "0.931" "0.877" "0.740" "0.753" "1.637" "81.7" "78.4" "76.8" "76.8" "77.7" "76.1" "71.7" "60.5" "61.5" "133.8" "" "" "" "" "" "" "" "" "" "" "72.5" "65.0" "67.0" "57.4" "64.8" "69.9" "60.6" "50.0" "56.4" "133.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "High" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.000" "False" "6.497" "3" "2" "3" "2" "791" "85.8" "6.32" "9.50" "2" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "Regulation of TP53 Activity through Phosphorylation; G2/M DNA damage checkpoint; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "11" "0" "0.989" "0.989" "1.054" "0.938" "0.878" "1.017" "0.942" "0.947" "0.836" "323.6" "320.0" "320.2" "341.0" "303.5" "284.1" "329.0" "304.8" "306.6" "270.7" "" "" "" "" "" "" "" "" "" "" "287.0" "265.1" "279.4" "255.0" "253.1" "261.0" "278.0" "252.0" "281.2" "270.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4556599553515132582" "False" "High" "IsMasterProtein" "Q6UB28" "Methionine aminopeptidase 1D, mitochondrial OS=Homo sapiens OX=9606 GN=METAP1D PE=1 SV=1" "0.000" "False" "6.494" "6" "2" "2" "2" "335" "37.1" "6.84" "8.36" "2" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf00557" "254042" "ENSG00000172878; ENSG00000292097" "METAP1D" "hsa:254042; Q1WNX3; Q6UB28" "" "" "0" "0" "1.027" "1.035" "1.123" "1.002" "1.094" "1.042" "0.995" "1.019" "0.554" "406.7" "417.5" "421.0" "456.7" "407.4" "445.0" "423.7" "404.8" "414.4" "225.5" "" "" "" "" "" "" "" "" "" "" "360.6" "345.9" "367.4" "341.6" "339.7" "408.8" "358.1" "334.6" "380.1" "225.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2062724590368512477" "False" "High" "IsMasterProtein" "Q684P5" "Rap1 GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RAP1GAP2 PE=1 SV=2" "0.000" "False" "6.494" "2" "1" "1" "1" "730" "80.0" "6.67" "4.08" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02145, Pf21022" "23108" "ENSG00000132359" "RAP1GAP2" "B2RTY5; hsa:23108; Q684P4; Q684P5; Q6AI00; Q6ZVF0; Q9UPW2" "Rap1 signalling" "" "1" "0" "1.234" "1.250" "0.972" "1.289" "0.878" "0.931" "0.612" "1.083" "6.207" "33.2" "41.0" "41.5" "32.3" "42.8" "29.2" "30.9" "20.3" "36.0" "206.0" "" "" "" "" "" "" "" "" "" "" "29.4" "33.9" "36.2" "24.1" "35.7" "26.8" "26.1" "16.8" "33.0" "206.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1157936408086935804" "False" "High" "IsMasterProtein" "O75446" "Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1" "0.000" "False" "6.492" "10" "2" "2" "2" "220" "23.3" "9.17" "5.87" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "8819" "ENSG00000164105" "SAP30" "D3DP38; hsa:8819; O75446" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "Retinoblastoma gene in cancer; Notch signaling pathway" "5" "0" "1.126" "0.901" "1.173" "0.895" "1.171" "1.128" "0.927" "1.014" "3.736" "86.2" "97.1" "77.7" "101.1" "77.2" "101.0" "97.3" "79.9" "87.5" "322.2" "" "" "" "" "" "" "" "" "" "" "76.5" "80.4" "67.8" "75.6" "64.4" "92.8" "82.2" "66.1" "80.2" "322.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9136449855438765080" "False" "High" "IsMasterProtein" "Q86XK2" "F-box only protein 11 OS=Homo sapiens OX=9606 GN=FBXO11 PE=1 SV=3" "0.000" "False" "6.487" "2" "1" "1" "1" "927" "103.5" "6.99" "4.81" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02207, Pf12937, Pf13229" "80204" "ENSG00000138081" "FBXO11" "A1L491; hsa:80204; Q52ZP1; Q53EP7; Q53RT5; Q86XK2; Q8IXG3; Q96E90; Q9H6V8; Q9H9L1; Q9NR14; Q9UFK1; Q9UHI1; Q9UKC2" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.407" "1.042" "1.173" "1.071" "1.380" "0.971" "1.344" "1.311" "1.095" "11.9" "16.7" "12.4" "13.9" "12.7" "16.4" "11.5" "15.9" "15.6" "13.0" "" "" "" "" "" "" "" "" "" "" "10.5" "13.8" "10.8" "10.4" "10.6" "15.0" "9.7" "13.2" "14.3" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5030873736405490960" "False" "High" "IsMasterProtein" "Q92686" "Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1" "0.000" "False" "6.487" "18" "1" "1" "1" "78" "7.6" "7.87" "5.40" "1" "developmental processes;signal transduction" "cytosol" "other molecular function" "Pf00612" "4900" "ENSG00000154146" "NRGN" "hsa:4900; Q92686" "Long-term potentiation" "" "1" "0" "1.080" "0.952" "1.075" "0.963" "0.933" "1.092" "1.148" "1.208" "0.522" "100.6" "108.6" "95.7" "108.1" "96.9" "93.8" "109.8" "115.4" "121.5" "52.5" "" "" "" "" "" "" "" "" "" "" "89.2" "90.0" "83.5" "80.9" "80.8" "86.1" "92.8" "95.4" "111.4" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7069915122482910766" "False" "High" "IsMasterProtein" "Q9Y2I7" "1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3" "0.000" "False" "6.477" "1" "2" "2" "2" "2098" "237.0" "6.70" "6.21" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00118, Pf00610, Pf01363, Pf01504" "200576" "ENSG00000115020" "PIKFYVE" "hsa:200576; Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67; Q9Y2I7" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1252831994268086785" "False" "High" "IsMasterProtein" "O00268" "Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2" "0.000" "False" "6.451" "2" "2" "2" "2" "1085" "110.0" "9.94" "4.92" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6874" "ENSG00000130699" "TAF4" "A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547321454778217727" "False" "High" "IsMasterProtein" "Q6PID6" "Tetratricopeptide repeat protein 33 OS=Homo sapiens OX=9606 GN=TTC33 PE=1 SV=2" "0.000" "False" "6.438" "5" "1" "1" "1" "262" "29.4" "5.44" "4.80" "1" "" "" "" "" "23548" "ENSG00000113638" "TTC33" "B2R6G0; hsa:23548; O95105; Q6PID6" "" "" "0" "0" "1.146" "1.079" "1.404" "1.010" "1.085" "1.187" "1.054" "1.050" "1.997" "88.7" "101.6" "95.7" "124.5" "89.6" "96.2" "105.2" "93.5" "93.1" "177.1" "" "" "" "" "" "" "" "" "" "" "78.6" "84.2" "83.5" "93.1" "74.7" "88.4" "88.9" "77.3" "85.4" "177.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1872362925255993666" "False" "High" "IsMasterProtein" "P17568" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFB7 PE=1 SV=4" "0.000" "False" "6.427" "14" "2" "2" "2" "137" "16.4" "8.92" "6.16" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05676" "4713" "ENSG00000099795" "NDUFB7" "hsa:4713; P17568; Q6ICN9; Q9UI16" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "1.063" "1.060" "1.127" "1.130" "1.112" "0.978" "1.043" "0.989" "0.269" "291.4" "309.8" "308.8" "328.5" "329.2" "324.2" "285.1" "303.9" "288.1" "78.5" "" "" "" "" "" "" "" "" "" "" "258.4" "256.6" "269.5" "245.7" "274.5" "297.8" "240.9" "251.2" "264.2" "78.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8182350314247288702" "False" "High" "IsMasterProtein" "Q9NVQ4" "Fas apoptotic inhibitory molecule 1 OS=Homo sapiens OX=9606 GN=FAIM PE=1 SV=1" "0.000" "False" "6.411" "12" "2" "2" "2" "179" "20.2" "5.83" "4.27" "2" "signal transduction;other biological processes" "other cell component" "" "Pf06905" "55179" "ENSG00000158234" "FAIM" "hsa:55179; Q6IAN2; Q9NVQ4" "" "Neurogenesis regulation in the olfactory epithelium" "1" "0" "1.213" "0.884" "1.838" "1.177" "0.747" "1.466" "0.820" "0.824" "1.669" "34.5" "41.8" "30.5" "63.4" "40.6" "25.7" "50.5" "28.3" "28.4" "57.5" "" "" "" "" "" "" "" "" "" "" "30.6" "34.6" "26.6" "47.4" "33.8" "23.6" "42.7" "23.4" "26.0" "57.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6291197193463572880" "False" "High" "IsMasterProtein" "Q9BWH2" "FUN14 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FUNDC2 PE=1 SV=2" "0.000" "False" "6.380" "6" "1" "1" "1" "189" "20.7" "9.73" "4.80" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf04930" "65991" "ENSG00000165775" "FUNDC2" "B2R7W5; D3DWY5; hsa:65991; Q8NHX8; Q9BWH2; Q9H2I6" "" "" "0" "0" "1.111" "1.180" "1.177" "1.176" "1.163" "1.160" "1.069" "1.119" "0.330" "221.4" "246.0" "261.4" "260.7" "260.4" "257.4" "256.9" "236.8" "247.9" "73.1" "" "" "" "" "" "" "" "" "" "" "196.4" "203.8" "228.1" "194.9" "217.1" "236.5" "217.1" "195.7" "227.3" "73.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312562393160644927" "False" "High" "IsMasterProtein" "Q8WV22" "Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5" "0.000" "False" "6.378" "6" "2" "2" "2" "266" "30.8" "7.47" "7.34" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07574, Pf08746" "197370" "ENSG00000169189" "NSMCE1" "D3DWF6; hsa:197370; Q8WV22; Q9P045; Q9P049" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5874507189654450183" "False" "High" "IsMasterProtein" "P50542" "Peroxisomal targeting signal 1 receptor OS=Homo sapiens OX=9606 GN=PEX5 PE=1 SV=3" "0.000" "False" "6.374" "4" "3" "3" "3" "639" "70.8" "4.54" "8.60" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13181" "5830" "ENSG00000139197; ENSG00000288217" "PEX5" "A8K891; B4DZ45; B7ZAD5; D3DUT8; hsa:5830; P50542; Q15115; Q15266; Q96FN7" "Pexophagy" "1p36 copy number variation syndrome" "2" "0" "1.051" "1.029" "1.206" "0.985" "0.993" "1.102" "0.747" "1.050" "6.391" "230.9" "242.8" "237.7" "278.6" "227.3" "229.2" "254.6" "172.5" "242.4" "1475.8" "" "" "" "" "" "" "" "" "" "" "204.8" "201.1" "207.4" "208.3" "189.6" "210.6" "215.1" "142.6" "222.3" "1475.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.000" "False" "6.373" "17" "2" "3" "2" "99" "10.7" "9.66" "9.05" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "0.775" "0.538" "0.600" "0.466" "0.350" "0.375" "0.566" "0.588" "0.232" "612.4" "474.3" "329.4" "367.7" "285.1" "214.3" "229.5" "346.6" "360.0" "142.1" "" "" "" "" "" "" "" "" "" "" "543.0" "392.9" "287.5" "275.0" "237.7" "196.9" "193.9" "286.5" "330.2" "142.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-431742904065760490" "False" "High" "IsMasterProtein" "O75955" "Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3" "0.000" "False" "6.371" "6" "3" "3" "3" "427" "47.3" "7.49" "5.90" "3" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "10211" "ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280" "FLOT1" "B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "8" "0" "1.033" "0.830" "0.889" "0.945" "0.977" "0.903" "0.852" "1.357" "0.615" "119.8" "123.7" "99.4" "106.4" "113.2" "117.0" "108.2" "102.0" "162.5" "73.6" "" "" "" "" "" "" "" "" "" "" "106.2" "102.5" "86.7" "79.6" "94.4" "107.4" "91.4" "84.3" "149.1" "73.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4546155412470536460" "False" "High" "IsMasterProtein" "Q9NQS7" "Inner centromere protein OS=Homo sapiens OX=9606 GN=INCENP PE=1 SV=3" "0.000" "False" "6.364" "2" "3" "3" "3" "918" "105.4" "9.44" "8.06" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03941, Pf12178" "3619" "ENSG00000149503" "INCENP" "A8MQD2; hsa:3619; Q5Y192; Q9NQS7" "SUMOylation of DNA replication proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.027" "0.972" "0.898" "0.898" "1.031" "0.903" "0.839" "0.896" "0.724" "403.1" "413.8" "391.6" "362.1" "362.0" "415.4" "363.9" "338.0" "361.2" "291.8" "" "" "" "" "" "" "" "" "" "" "357.4" "342.8" "341.7" "270.8" "301.8" "381.6" "307.6" "279.4" "331.3" "291.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.000" "False" "6.351" "3" "3" "3" "3" "756" "84.5" "5.72" "8.14" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "12" "0" "0.978" "0.892" "0.983" "0.914" "0.909" "0.915" "0.466" "0.951" "10.502" "142.1" "139.0" "126.8" "139.8" "130.0" "129.2" "130.1" "66.3" "135.2" "1492.6" "" "" "" "" "" "" "" "" "" "" "126.0" "115.1" "110.7" "104.5" "108.4" "118.6" "109.9" "54.8" "124.0" "1492.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8814237146634600983" "False" "High" "IsMasterProtein" "Q15642" "Cdc42-interacting protein 4 OS=Homo sapiens OX=9606 GN=TRIP10 PE=1 SV=3" "0.000" "False" "6.337" "4" "1" "1" "1" "601" "68.3" "5.73" "4.66" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "9322" "ENSG00000125733" "TRIP10" "B2R8A6; B7WP22; D6W645; hsa:9322; O15184; Q15642; Q53G22; Q5TZN1; Q6FI24; Q8NFL1; Q8TCY1; Q8TDX3; Q96RJ1" "RHOQ GTPase cycle; Clathrin-mediated endocytosis" "Angiopoietin-like protein 8 regulatory pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "265917510829417511" "False" "High" "IsMasterProtein" "Q5JS37" "NHL repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=NHLRC3 PE=1 SV=1" "0.000" "False" "6.334" "5" "1" "1" "1" "347" "38.3" "6.43" "4.82" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf01436" "387921" "ENSG00000188811" "NHLRC3" "B2RTZ2; B4DTL0; hsa:387921; Q5JS37; Q69YI9" "Neutrophil degranulation" "" "1" "0" "0.982" "1.124" "1.007" "0.979" "1.252" "1.038" "0.986" "1.057" "0.696" "100.1" "98.3" "112.4" "100.7" "98.0" "125.3" "103.9" "98.7" "105.7" "69.7" "" "" "" "" "" "" "" "" "" "" "88.7" "81.4" "98.1" "75.3" "81.7" "115.1" "87.8" "81.6" "97.0" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.000" "False" "6.318" "1" "1" "1" "1" "670" "75.4" "9.50" "4.67" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "1.061" "0.849" "0.880" "0.818" "0.958" "0.714" "0.711" "0.815" "0.715" "159.9" "169.7" "135.8" "140.7" "130.7" "153.2" "114.2" "113.8" "130.3" "114.3" "" "" "" "" "" "" "" "" "" "" "141.8" "140.5" "118.5" "105.2" "109.0" "140.7" "96.5" "94.0" "119.5" "114.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1233301175711817625" "False" "High" "IsMasterProtein" "P21926" "CD9 antigen OS=Homo sapiens OX=9606 GN=CD9 PE=1 SV=4" "0.000" "False" "6.316" "7" "2" "3" "2" "228" "25.4" "7.15" "10.96" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf00335" "928" "ENSG00000010278" "CD9" "D3DUQ9; hsa:928; P21926; Q5J7W6; Q96ES4" "Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding" "Vitamin D receptor pathway" "4" "0" "1.132" "0.975" "0.927" "1.078" "1.131" "1.074" "1.083" "1.754" "0.711" "769.4" "870.8" "750.1" "713.0" "829.8" "870.0" "826.1" "833.7" "1349.5" "546.7" "" "" "" "" "" "" "" "" "" "" "682.3" "721.3" "654.5" "533.2" "691.9" "799.2" "698.2" "689.1" "1237.7" "546.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450384486208506068" "False" "High" "IsMasterProtein" "Q96LD4" "E3 ubiquitin-protein ligase TRIM47 OS=Homo sapiens OX=9606 GN=TRIM47 PE=1 SV=2" "0.000" "False" "6.297" "2" "1" "1" "1" "638" "69.5" "6.44" "4.41" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00643, Pf13445" "91107" "ENSG00000132481" "TRIM47" "hsa:91107; Q96AD0; Q96GU5; Q96LD4; Q9BRN7" "" "" "0" "0" "0.914" "1.070" "0.827" "0.863" "0.806" "1.000" "0.767" "1.213" "2.660" "59.3" "54.2" "63.5" "49.0" "51.2" "47.8" "59.3" "45.5" "71.9" "157.8" "" "" "" "" "" "" "" "" "" "" "52.6" "44.9" "55.4" "36.7" "42.7" "43.9" "50.1" "37.6" "66.0" "157.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6965431405701772987" "False" "High" "IsMasterProtein" "Q8N612" "FHF complex subunit HOOK-interacting protein 1B OS=Homo sapiens OX=9606 GN=FHIP1B PE=1 SV=3" "0.000" "False" "6.296" "2" "1" "1" "1" "972" "105.5" "6.77" "6.42" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "" "Pf10257, Pf19311, Pf19314" "84067" "ENSG00000051009" "FHIP1B" "hsa:84067; Q8N612; Q9C0A4; Q9H0N3; Q9H624" "" "" "0" "0" "1.025" "1.183" "0.917" "0.869" "0.929" "0.771" "0.809" "0.875" "1.456" "45.4" "46.5" "53.7" "41.6" "39.5" "42.2" "35.0" "36.7" "39.7" "66.1" "" "" "" "" "" "" "" "" "" "" "40.3" "38.6" "46.9" "31.1" "32.9" "38.8" "29.6" "30.4" "36.4" "66.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8524788288681439212" "False" "High" "IsMasterProtein" "O15164" "Transcription intermediary factor 1-alpha OS=Homo sapiens OX=9606 GN=TRIM24 PE=1 SV=3" "0.000" "False" "6.292" "2" "2" "2" "1" "1050" "116.8" "7.11" "6.86" "2" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf00628, Pf00643" "8805" "ENSG00000122779" "TRIM24" "A4D1R7; A4D1R8; hsa:8805; O15164; O95854" "Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8021819990662325449" "False" "High" "IsMasterProtein" "O43760" "Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1" "0.000" "False" "6.291" "8" "2" "4" "2" "224" "24.8" "4.94" "10.98" "2" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01284" "9144" "ENSG00000108639" "SYNGR2" "hsa:9144; O43760; O43762; Q3KQZ2; Q658S7" "" "" "0" "0" "1.025" "0.982" "1.051" "1.092" "0.986" "1.086" "1.058" "0.951" "0.814" "359.6" "368.7" "353.0" "378.0" "392.6" "354.6" "390.6" "380.4" "342.0" "292.7" "" "" "" "" "" "" "" "" "" "" "318.8" "305.4" "308.0" "282.7" "327.4" "325.7" "330.1" "314.4" "313.7" "292.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7817133127766930839" "False" "High" "IsMasterProtein" "Q93050" "V-type proton ATPase 116 kDa subunit a 1 OS=Homo sapiens OX=9606 GN=ATP6V0A1 PE=1 SV=3" "0.000" "False" "6.289" "1" "1" "1" "1" "837" "96.4" "6.43" "4.26" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01496" "535" "ENSG00000033627" "ATP6V0A1" "B7Z3B7; hsa:535; Q8N5G7; Q93050; Q9NSX0" "Neutrophil degranulation; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3811066710026793793" "False" "High" "IsMasterProtein" "P21580" "Tumor necrosis factor alpha-induced protein 3 OS=Homo sapiens OX=9606 GN=TNFAIP3 PE=1 SV=1" "0.000" "False" "6.289" "4" "3" "3" "3" "790" "89.6" "8.22" "6.47" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01754, Pf02338" "7128" "ENSG00000118503" "TNFAIP3" "B2R767; E1P588; hsa:7128; P21580; Q2HIX9; Q5VXQ7; Q9NSR6" "NOD1/2 Signaling Pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TNFR1-induced proapoptotic signaling" "TNF-alpha signaling pathway; Vitamin D receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Measles virus infection; IL-18 signaling pathway; Burn wound healing; Modulators of TCR signaling and T cell activation" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "415707649714952015" "False" "High" "IsMasterProtein" "P38398" "Breast cancer type 1 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA1 PE=1 SV=2" "0.000" "False" "6.287" "1" "3" "3" "3" "1863" "207.6" "5.41" "8.25" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00097, Pf00533, Pf12820" "672" "ENSG00000012048" "BRCA1" "E9PFZ0; hsa:672; O15129; P38398; Q1RMC1; Q3LRJ0; Q3LRJ6; Q6IN79; Q7KYU9" "Meiotic synapsis; Resolution of D-loop Structures through Holliday Junction Intermediates; Neddylation; KEAP1-NFE2L2 pathway; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Transcriptional Regulation by E2F6; Metalloprotease DUBs; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Nonhomologous End-Joining (NHEJ); Defective DNA double strand break response due to BRCA1 loss of function; Defective DNA double strand break response due to BARD1 loss of function" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Glioblastoma signaling pathways; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; PI3K-Akt signaling pathway; Breast cancer pathway; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; 5q35 copy number variation; DNA damage response" "40" "0" "0.929" "0.739" "0.833" "0.763" "0.807" "0.794" "0.656" "0.780" "1.462" "244.7" "227.5" "180.9" "203.8" "186.7" "197.5" "194.2" "160.5" "191.0" "357.7" "" "" "" "" "" "" "" "" "" "" "217.0" "188.4" "157.8" "152.4" "155.7" "181.5" "164.1" "132.7" "175.1" "357.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637466038943732411" "False" "High" "IsMasterProtein" "Q5W111" "SPRY domain-containing protein 7 OS=Homo sapiens OX=9606 GN=SPRYD7 PE=1 SV=2" "0.000" "False" "6.283" "11" "2" "4" "2" "196" "21.7" "6.70" "9.07" "2" "" "" "" "Pf00622" "57213" "ENSG00000123178" "SPRYD7" "A8K3G1; hsa:57213; O60648; Q5W111; Q8TBG8; Q96T69" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384672400329607231" "False" "High" "IsMasterProtein" "Q64LD2" "WD repeat-containing protein 25 OS=Homo sapiens OX=9606 GN=WDR25 PE=1 SV=3" "0.000" "False" "6.281" "2" "1" "1" "1" "544" "60.1" "9.00" "4.07" "1" "" "" "" "Pf00400" "79446" "ENSG00000176473" "WDR25" "A8K7E5; hsa:79446; Q64LD2; Q6NVV6; Q86TQ4; Q9BTK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1463147851844743344" "False" "High" "IsMasterProtein" "Q9HCG8" "Pre-mRNA-splicing factor CWC22 homolog OS=Homo sapiens OX=9606 GN=CWC22 PE=1 SV=3" "0.000" "False" "6.278" "1" "1" "2" "1" "908" "105.4" "7.03" "3.65" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf02847, Pf02854" "57703" "ENSG00000163510" "CWC22" "hsa:57703; Q05DC2; Q4G135; Q52LF0; Q6PEX2; Q7Z6I0; Q9H5L3; Q9H6Q6; Q9HCG8" "mRNA Splicing - Major Pathway" "" "1" "0" "0.960" "0.956" "1.132" "0.775" "0.947" "0.877" "0.706" "0.898" "5.382" "131.7" "126.5" "125.8" "149.1" "102.0" "124.7" "115.4" "92.9" "118.3" "708.6" "" "" "" "" "" "" "" "" "" "" "116.8" "104.8" "109.8" "111.5" "85.1" "114.6" "97.5" "76.8" "108.5" "708.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6592618097650740774" "False" "High" "IsMasterProtein" "Q9UDY2" "Tight junction protein ZO-2 OS=Homo sapiens OX=9606 GN=TJP2 PE=1 SV=2" "0.000" "False" "6.276" "2" "3" "3" "3" "1190" "133.9" "7.40" "8.90" "3" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00595, Pf00625, Pf07653" "9414" "ENSG00000119139" "TJP2" "A2A3H9; B7Z2R8; B7Z7T6; F5H301; F5H886; hsa:9414; Q15883; Q5VXL0; Q5VXL1; Q8N756; Q8NI14; Q99839; Q9UDY0; Q9UDY1; Q9UDY2" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Signaling by Hippo; Apoptotic cleavage of cell adhesion proteins" "1q21.1 copy number variation syndrome; 15q11q13 copy number variation" "7" "0" "0.999" "0.923" "0.992" "1.070" "1.016" "1.052" "0.907" "1.021" "2.336" "154.9" "154.7" "143.0" "153.7" "165.8" "157.4" "162.9" "140.5" "158.2" "361.9" "" "" "" "" "" "" "" "" "" "" "137.4" "128.2" "124.7" "115.0" "138.2" "144.6" "137.7" "116.2" "145.1" "361.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1768771022967141070" "False" "High" "IsMasterProtein" "Q9Y4H4" "G-protein-signaling modulator 3 OS=Homo sapiens OX=9606 GN=GPSM3 PE=1 SV=1" "0.000" "False" "6.274" "14" "1" "2" "1" "160" "17.9" "4.97" "10.49" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf02188" "63940" "ENSG00000206314; ENSG00000213654; ENSG00000233490; ENSG00000234243; ENSG00000234508; ENSG00000236697; ENSG00000237052" "GPSM3" "A2BFJ3; hsa:63940; Q9Y4H4" "G alpha (i) signalling events" "" "1" "0" "1.005" "0.966" "1.011" "1.169" "1.009" "0.825" "1.067" "0.834" "0.454" "100.7" "101.2" "97.3" "101.7" "117.7" "101.6" "83.0" "107.4" "83.9" "45.7" "" "" "" "" "" "" "" "" "" "" "89.3" "83.8" "84.9" "76.1" "98.2" "93.3" "70.2" "88.8" "77.0" "45.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8213530415283437885" "False" "High" "IsMasterProtein" "Q9Y2R0" "Cytochrome c oxidase assembly factor 3 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA3 PE=1 SV=1" "0.000" "False" "6.270" "18" "2" "2" "2" "106" "11.7" "9.60" "8.44" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09813" "28958" "ENSG00000183978" "COA3" "A8K498; hsa:28958; Q9Y2R0" "" "Mitochondrial complex IV assembly; Arsenic metabolism and reactive oxygen species generation" "2" "0" "0.889" "1.039" "1.017" "0.829" "0.975" "0.976" "0.928" "1.022" "1.045" "70.3" "62.5" "73.0" "71.5" "58.3" "68.5" "68.6" "65.2" "71.8" "73.5" "" "" "" "" "" "" "" "" "" "" "62.3" "51.8" "63.7" "53.5" "48.6" "63.0" "58.0" "53.9" "65.9" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8343966935655594345" "False" "High" "IsMasterProtein" "P56385" "ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2" "0.000" "False" "6.266" "14" "1" "1" "1" "69" "7.9" "9.35" "5.06" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05680" "521" "ENSG00000169020" "ATP5ME" "hsa:521; P56385; Q0D2L9" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "1.088" "0.941" "1.049" "1.065" "0.983" "1.115" "1.158" "1.305" "0.706" "274.8" "299.0" "258.6" "288.1" "292.6" "270.2" "306.4" "318.2" "358.5" "193.9" "" "" "" "" "" "" "" "" "" "" "243.7" "247.7" "225.6" "215.5" "244.0" "248.2" "258.9" "263.0" "328.8" "193.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2487985857359002276" "False" "High" "IsMasterProtein" "Q8IWU2" "Serine/threonine-protein kinase LMTK2 OS=Homo sapiens OX=9606 GN=LMTK2 PE=1 SV=2" "0.000" "False" "6.262" "1" "1" "1" "1" "1503" "164.8" "4.48" "4.12" "1" "protein metabolism;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf07714" "22853" "ENSG00000164715" "LMTK2" "A4D272; hsa:22853; Q75MG7; Q8IWU2; Q9UPS3" "" "" "0" "0" "1.205" "1.003" "1.009" "0.958" "0.943" "0.933" "1.113" "1.063" "0.778" "79.3" "95.5" "79.5" "80.0" "76.0" "74.8" "74.0" "88.3" "84.3" "61.7" "" "" "" "" "" "" "" "" "" "" "70.3" "79.1" "69.4" "59.8" "63.4" "68.7" "62.5" "73.0" "77.3" "61.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179808201318642480" "False" "High" "IsMasterProtein" "Cont_Q3SZR3" "Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1" "0.000" "True" "6.261" "11" "3" "3" "3" "202" "23.2" "5.87" "11.24" "3" "stress response;other biological processes" "non-structural extracellular" "" "Pf00061" "497200" "" "ORM1" "bta:497200; Q3SZR3" "" "" "0" "0" "1.120" "1.015" "0.767" "1.233" "0.837" "1.132" "1.360" "1.033" "0.467" "647.0" "724.6" "656.9" "496.0" "797.9" "541.4" "732.1" "879.7" "668.3" "302.0" "" "" "" "" "" "" "" "" "" "" "573.7" "600.2" "573.1" "370.9" "665.3" "497.3" "618.8" "727.1" "612.9" "302.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6609542144732775052" "False" "High" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "0.000" "False" "6.258" "2" "2" "2" "2" "738" "80.5" "6.92" "6.09" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "1.049" "0.985" "1.012" "0.990" "1.024" "0.958" "0.867" "0.990" "1.455" "157.1" "164.8" "154.7" "159.0" "155.6" "160.9" "150.5" "136.3" "155.5" "228.7" "" "" "" "" "" "" "" "" "" "" "139.3" "136.5" "135.0" "118.9" "129.8" "147.8" "127.2" "112.7" "142.6" "228.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7148094604996287167" "False" "High" "IsMasterProtein" "Q9Y3E1" "Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1" "0.000" "False" "6.255" "8" "2" "6" "1" "203" "22.6" "7.99" "16.11" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00855" "50810" "ENSG00000166503" "HDGFL3" "hsa:50810; Q9Y3E1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "6.253" "12" "3" "3" "3" "188" "20.8" "9.66" "9.16" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.061" "0.922" "1.186" "1.051" "0.940" "1.117" "0.946" "0.933" "1.738" "329.5" "349.6" "303.8" "390.7" "346.5" "309.8" "368.1" "311.6" "307.4" "572.8" "" "" "" "" "" "" "" "" "" "" "292.2" "289.6" "265.1" "292.2" "288.9" "284.5" "311.1" "257.6" "282.0" "572.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "935705506060532462" "False" "High" "IsMasterProtein" "A0A0U1RRE5" "Negative regulator of P-body association OS=Homo sapiens OX=9606 GN=NBDY PE=1 SV=1" "0.000" "False" "6.248" "25" "2" "6" "2" "68" "7.0" "9.42" "17.51" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "" "" "550643" "ENSG00000204272" "NBDY" "A0A0U1RRE5" "" "" "0" "0" "0.850" "0.812" "0.934" "0.766" "0.849" "0.849" "0.880" "0.920" "0.557" "446.3" "379.3" "362.5" "416.9" "341.8" "378.7" "379.1" "392.5" "410.4" "248.8" "" "" "" "" "" "" "" "" "" "" "395.8" "314.2" "316.3" "311.8" "285.0" "347.9" "320.4" "324.5" "376.4" "248.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8114162095880212588" "False" "High" "IsMasterProtein" "Q9H3S7" "Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1" "0.000" "False" "6.221" "1" "2" "2" "2" "1636" "178.9" "6.92" "6.54" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102, Pf03097, Pf13949" "25930" "ENSG00000076201" "PTPN23" "A8K0D7; hsa:25930; Q7KZF8; Q8N6Z5; Q9BSR5; Q9H3S7; Q9P257; Q9UG03; Q9UMZ4" "Interleukin-37 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-973328225883047536" "False" "High" "IsMasterProtein" "Q8IV48" "3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3" "0.000" "False" "6.206" "5" "2" "2" "2" "349" "40.0" "6.70" "7.29" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00929, Pf02037" "90459" "ENSG00000104626" "ERI1" "A8K4U7; hsa:90459; Q8IV48; Q9NSX3" "Major pathway of rRNA processing in the nucleolus and cytosol" "exRNA mechanism of action and biogenesis; 8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4212925493234983848" "False" "High" "IsMasterProtein" "Q14289" "Protein-tyrosine kinase 2-beta OS=Homo sapiens OX=9606 GN=PTK2B PE=1 SV=2" "0.000" "False" "6.197" "2" "2" "2" "1" "1009" "115.8" "6.25" "3.13" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "transporter activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "2185" "ENSG00000120899" "PTK2B" "D3DST0; hsa:2185; Q13475; Q14289; Q14290; Q16709; Q6PID4" "RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Signal regulatory protein family interactions; Interleukin-2 signaling" "IL-7 signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-2 signaling pathway; CCL18 signaling pathway; NPHP1 deletion syndrome; 8q11.23 (RB1CC1) copy number variation; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "21" "0" "1.118" "0.959" "1.308" "1.040" "0.991" "1.175" "0.601" "0.993" "8.335" "89.4" "99.9" "85.8" "116.9" "93.0" "88.6" "105.0" "53.7" "88.8" "745.2" "" "" "" "" "" "" "" "" "" "" "79.3" "82.8" "74.8" "87.4" "77.6" "81.4" "88.8" "44.4" "81.5" "745.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6386992515294996358" "False" "High" "IsMasterProtein" "Q8IUZ5" "5-phosphohydroxy-L-lysine phospho-lyase OS=Homo sapiens OX=9606 GN=PHYKPL PE=1 SV=1" "0.000" "False" "6.196" "2" "1" "1" "1" "450" "49.7" "6.76" "4.30" "1" "" "mitochondrion" "other molecular function" "Pf00202" "85007" "ENSG00000175309" "PHYKPL" "A8K7P6; B3KN36; D3DWP9; hsa:85007; Q8IUZ5; Q8WYS6; Q96HW8" "Lysine catabolism; Collagen degradation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5759513507169389480" "False" "High" "IsMasterProtein" "Q9H7X3" "Zinc finger protein 696 OS=Homo sapiens OX=9606 GN=ZNF696 PE=1 SV=2" "0.000" "False" "6.181" "3" "1" "4" "1" "374" "40.5" "8.92" "5.18" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "79943" "ENSG00000185730" "ZNF696" "A0AVE2; hsa:79943; Q9H7X3" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "741351973509792209" "False" "High" "IsMasterProtein" "Q9BUL9" "Ribonuclease P protein subunit p25 OS=Homo sapiens OX=9606 GN=RPP25 PE=1 SV=1" "0.000" "False" "6.177" "13" "2" "2" "2" "199" "20.6" "9.61" "6.34" "2" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01918" "54913" "ENSG00000178718" "RPP25" "D3DW70; Q9BUL9; Q9NX88" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "" "2" "0" "0.931" "0.798" "1.185" "0.899" "0.988" "1.168" "0.909" "0.905" "0.470" "43.4" "40.4" "34.7" "51.5" "39.0" "42.9" "50.7" "39.5" "39.3" "20.4" "" "" "" "" "" "" "" "" "" "" "38.5" "33.5" "30.3" "38.5" "32.5" "39.4" "42.9" "32.6" "36.0" "20.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.000" "False" "6.166" "8" "2" "2" "2" "204" "24.1" "11.62" "5.87" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.988" "0.890" "1.102" "1.012" "0.883" "0.918" "0.935" "0.926" "1.073" "205.8" "203.3" "183.1" "226.7" "208.3" "181.6" "189.0" "192.5" "190.6" "220.7" "" "" "" "" "" "" "" "" "" "" "182.5" "168.4" "159.8" "169.6" "173.7" "166.8" "159.7" "159.1" "174.8" "220.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-998134309870178967" "False" "High" "IsMasterProtein" "P47974" "mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3" "0.000" "False" "6.137" "3" "1" "1" "1" "494" "51.0" "8.16" "4.84" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "678" "ENSG00000152518" "ZFP36L2" "hsa:678; P47974; Q53TB4; Q9BSJ3" "M-decay: degradation of maternal mRNAs by maternally stored factors" "Pre-implantation embryo; TYROBP causal network in microglia" "3" "0" "0.933" "0.848" "1.020" "0.753" "0.857" "0.901" "0.874" "0.841" "1.620" "84.7" "79.0" "71.8" "86.4" "63.8" "72.6" "76.3" "74.0" "71.3" "137.2" "" "" "" "" "" "" "" "" "" "" "75.1" "65.5" "62.7" "64.6" "53.2" "66.7" "64.5" "61.2" "65.4" "137.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-760926983399472078" "False" "High" "IsMasterProtein" "P57060" "RWD domain-containing protein 2B OS=Homo sapiens OX=9606 GN=RWDD2B PE=1 SV=1" "0.000" "False" "6.129" "5" "2" "2" "2" "319" "36.3" "5.87" "6.23" "2" "" "" "" "Pf05773, Pf06544" "10069" "ENSG00000156253; ENSG00000291523" "RWDD2B" "hsa:10069; P57060" "" "" "0" "0" "0.957" "0.906" "1.093" "0.858" "0.920" "0.919" "0.518" "0.813" "5.734" "169.7" "162.4" "153.8" "185.5" "145.6" "156.2" "155.9" "88.0" "138.0" "972.9" "" "" "" "" "" "" "" "" "" "" "150.5" "134.5" "134.2" "138.7" "121.4" "143.5" "131.8" "72.7" "126.6" "972.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781411655815037660" "False" "High" "IsMasterProtein" "P14316" "Interferon regulatory factor 2 OS=Homo sapiens OX=9606 GN=IRF2 PE=1 SV=2" "0.000" "False" "6.124" "7" "3" "3" "3" "349" "39.3" "7.52" "7.74" "3" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605" "3660" "ENSG00000168310" "IRF2" "D6RCK5; H0Y8S3; hsa:3660; P14316; Q6IAS7; Q96B99" "Interferon gamma signaling; Factors involved in megakaryocyte development and platelet production; Interferon alpha/beta signaling; Pyroptosis" "Apoptosis; Rubinstein-Taybi syndrome 1; Type II interferon signaling" "7" "0" "1.033" "0.990" "0.982" "0.930" "0.970" "1.067" "0.932" "1.130" "0.853" "262.7" "271.5" "260.0" "257.9" "244.5" "255.0" "280.2" "244.8" "297.0" "224.1" "" "" "" "" "" "" "" "" "" "" "233.0" "224.9" "226.9" "192.9" "203.8" "234.2" "236.8" "202.3" "272.4" "224.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3291492461093928575" "False" "High" "IsMasterProtein" "Q8NC69" "BTB/POZ domain-containing protein KCTD6 OS=Homo sapiens OX=9606 GN=KCTD6 PE=1 SV=2" "0.000" "False" "6.123" "5" "1" "1" "1" "237" "27.6" "5.96" "4.32" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf02214" "200845" "ENSG00000168301" "KCTD6" "B3KNI5; hsa:200845; Q8NBS6; Q8NC69; Q8TCA6" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Estrogen-dependent gene expression; RUNX1 regulates estrogen receptor mediated transcription" "" "4" "0" "1.077" "1.067" "1.237" "1.235" "1.048" "1.137" "1.125" "0.990" "0.503" "194.7" "209.6" "207.7" "240.8" "240.4" "204.0" "221.5" "219.0" "192.8" "97.8" "" "" "" "" "" "" "" "" "" "" "172.7" "173.6" "181.3" "180.1" "200.5" "187.4" "187.2" "181.0" "176.9" "97.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097092162087690863" "False" "High" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.000" "False" "6.121" "1" "2" "2" "2" "1085" "122.3" "6.47" "5.44" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "9" "0" "0.972" "0.926" "0.964" "0.844" "0.855" "0.827" "0.495" "0.999" "5.550" "93.8" "91.1" "86.8" "90.4" "79.1" "80.2" "77.6" "46.4" "93.7" "520.5" "" "" "" "" "" "" "" "" "" "" "83.2" "75.5" "75.7" "67.6" "66.0" "73.7" "65.5" "38.4" "85.9" "520.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867390860608568122" "False" "High" "IsMasterProtein" "Q9BRJ2" "Large ribosomal subunit protein mL45 OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" "0.000" "False" "6.118" "3" "1" "1" "1" "306" "35.3" "9.03" "4.25" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf04280" "" "ENSG00000277936" "MRPL45" "A1L436; Q6ZMJ5; Q9BRJ2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5800402154155294758" "False" "High" "IsMasterProtein" "Q8N300" "Small vasohibin-binding protein OS=Homo sapiens OX=9606 GN=SVBP PE=1 SV=1" "0.000" "False" "6.112" "23" "1" "1" "1" "66" "7.8" "9.16" "4.78" "1" "cell organization and biogenesis;protein metabolism;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf15674" "374969" "ENSG00000177868" "SVBP" "A8K5P1; D3DPW7; hsa:374969; Q8N300" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "1.028" "1.040" "1.096" "1.066" "0.933" "1.172" "1.119" "1.047" "0.490" "182.1" "187.2" "189.5" "199.6" "194.1" "170.0" "213.5" "203.8" "190.6" "89.2" "" "" "" "" "" "" "" "" "" "" "161.5" "155.0" "165.3" "149.3" "161.9" "156.2" "180.4" "168.4" "174.8" "89.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "6.107" "2" "2" "2" "2" "960" "111.6" "7.87" "6.46" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Mitochondrial protein degradation; Regulation of Apoptosis" "Orexin receptor pathway" "3" "0" "0.734" "0.731" "0.802" "0.702" "0.805" "0.835" "0.734" "0.863" "1.829" "81.0" "59.4" "59.2" "65.0" "56.9" "65.2" "67.6" "59.5" "69.9" "148.1" "" "" "" "" "" "" "" "" "" "" "71.8" "49.2" "51.6" "48.6" "47.4" "59.9" "57.1" "49.1" "64.1" "148.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144026174049458249" "False" "High" "IsMasterProtein" "Q99574" "Neuroserpin OS=Homo sapiens OX=9606 GN=SERPINI1 PE=1 SV=1" "0.000" "False" "6.104" "2" "1" "2" "1" "410" "46.4" "4.91" "4.90" "1" "developmental processes;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "5274" "ENSG00000163536" "SERPINI1" "A8K217; D3DNP1; hsa:5274; Q6AHZ4; Q99574" "" "" "0" "0" "1.047" "0.912" "1.116" "1.100" "0.961" "1.625" "1.621" "1.476" "0.704" "111.3" "116.5" "101.4" "124.2" "122.4" "106.9" "180.8" "180.4" "164.2" "78.4" "" "" "" "" "" "" "" "" "" "" "98.7" "96.5" "88.5" "92.9" "102.1" "98.2" "152.8" "149.1" "150.6" "78.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7546150518504420539" "False" "High" "IsMasterProtein" "O00186" "Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2" "0.000" "False" "6.100" "3" "2" "2" "2" "592" "67.7" "7.80" "6.24" "2" "cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00995" "6814" "ENSG00000116266" "STXBP3" "A8K269; A8K5K7; hsa:6814; O00186; Q53FW1; Q86YJ3; Q9UPD7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation" "Insulin signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564632356119292656" "False" "High" "IsMasterProtein" "P04843" "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1" "0.000" "False" "6.100" "3" "2" "2" "2" "607" "68.5" "6.38" "6.65" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf04597" "6184" "ENSG00000163902" "RPN1" "B2R5Z0; D3DNB6; hsa:6184; P04843; Q68DT1" "SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein" "Proteasome degradation; N-glycan biosynthesis" "5" "0" "1.040" "0.995" "1.027" "1.238" "0.890" "1.126" "0.855" "1.157" "0.560" "117.4" "122.1" "116.9" "120.6" "145.4" "104.5" "132.2" "100.4" "135.8" "65.8" "" "" "" "" "" "" "" "" "" "" "104.1" "101.1" "102.0" "90.2" "121.3" "96.0" "111.7" "83.0" "124.6" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5441876211868438473" "False" "High" "IsMasterProtein" "Q92585" "Mastermind-like protein 1 OS=Homo sapiens OX=9606 GN=MAML1 PE=1 SV=3" "0.000" "False" "6.094" "2" "2" "2" "2" "1016" "108.0" "8.28" "6.36" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09596, Pf20801, Pf20802" "9794" "ENSG00000161021; ENSG00000283780" "MAML1" "hsa:9794; Q92585; Q9NZ12" "NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Transcription and Translation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Notch signaling; Canonical and non-canonical Notch signaling; Head and neck squamous cell carcinoma; Notch signaling pathway" "15" "0" "1.095" "1.035" "1.182" "0.990" "0.968" "0.980" "0.991" "1.028" "0.948" "197.2" "215.9" "204.2" "233.2" "195.3" "190.9" "193.3" "195.4" "202.7" "186.9" "" "" "" "" "" "" "" "" "" "" "174.9" "178.8" "178.2" "174.4" "162.8" "175.4" "163.4" "161.5" "185.9" "186.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7498924071980765815" "False" "High" "IsMasterProtein" "Q9Y2G3" "Phospholipid-transporting ATPase IF OS=Homo sapiens OX=9606 GN=ATP11B PE=1 SV=2" "0.000" "False" "6.094" "1" "1" "1" "1" "1177" "134.1" "6.96" "4.61" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00702, Pf13246, Pf16209, Pf16212" "23200" "ENSG00000058063" "ATP11B" "hsa:23200; Q96FN1; Q9UKK7; Q9Y2G3" "Neutrophil degranulation; Ion transport by P-type ATPases" "" "2" "0" "1.106" "0.945" "1.218" "1.246" "0.986" "1.297" "1.060" "1.122" "0.999" "101.3" "112.1" "95.8" "123.4" "126.3" "99.9" "131.4" "107.4" "113.7" "101.3" "" "" "" "" "" "" "" "" "" "" "89.9" "92.9" "83.6" "92.3" "105.3" "91.8" "111.1" "88.7" "104.3" "101.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7766499346682965111" "False" "High" "IsMasterProtein" "Q99583" "Max-binding protein MNT OS=Homo sapiens OX=9606 GN=MNT PE=1 SV=1" "0.000" "False" "6.094" "2" "1" "1" "1" "582" "62.3" "8.78" "3.95" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4335" "ENSG00000070444" "MNT" "A8K6D1; D3DTI7; hsa:4335; Q1ED38; Q99583" "" "" "0" "0" "1.180" "1.180" "1.218" "1.022" "1.018" "1.244" "1.065" "1.068" "1.150" "79.6" "93.9" "93.9" "96.9" "81.4" "81.0" "99.0" "84.7" "85.0" "91.5" "" "" "" "" "" "" "" "" "" "" "70.6" "77.8" "82.0" "72.5" "67.8" "74.4" "83.6" "70.0" "78.0" "91.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5026099811254189140" "False" "High" "IsMasterProtein" "P11166" "Solute carrier family 2, facilitated glucose transporter member 1 OS=Homo sapiens OX=9606 GN=SLC2A1 PE=1 SV=2" "0.000" "False" "6.088" "2" "1" "1" "1" "492" "54.0" "8.72" "3.99" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00083" "6513" "ENSG00000117394" "SLC2A1" "A8K9S6; B2R620; D3DPX0; hsa:6513; O75535; P11166; Q0P512; Q147X2" "Cellular hexose transport; Regulation of insulin secretion; Vitamin C (ascorbate) metabolism; Lactose synthesis; Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Insulin signaling; Proximal tubule transport; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Amino acid metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Chronic hyperglycemia impairment of neuron function; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; Pancreatic cancer subtypes; 15q25 copy number variation; GLP-1 in pancreatic islet cells; GLP-1 from intestine and pancreas and role in glucose homeostasis" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8314583423527293992" "False" "High" "IsMasterProtein" "Q96SZ6" "Mitochondrial tRNA methylthiotransferase CDK5RAP1 OS=Homo sapiens OX=9606 GN=CDK5RAP1 PE=1 SV=2" "0.000" "False" "6.088" "4" "2" "2" "2" "601" "67.6" "8.21" "6.63" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00919, Pf01938, Pf04055" "51654" "ENSG00000101391" "CDK5RAP1" "A8K7R0; hsa:51654; Q5QP46; Q5QP47; Q5QP48; Q675N4; Q675N5; Q96SZ6; Q9BVG6; Q9BWZ5; Q9H859; Q9NZZ9; Q9Y3F0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3330412660782960382" "False" "High" "IsMasterProtein" "Q16594" "Transcription initiation factor TFIID subunit 9 OS=Homo sapiens OX=9606 GN=TAF9 PE=1 SV=1" "0.000" "False" "6.087" "6" "2" "2" "2" "264" "29.0" "8.66" "6.40" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02291" "6880" "ENSG00000273841; ENSG00000276463" "TAF9" "D3DWA3; hsa:6880; Q16594; Q5U0D1; Q9BTS1" "HATs acetylate histones; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "Eukaryotic transcription initiation" "12" "0" "0.931" "0.901" "0.974" "0.985" "0.920" "0.961" "0.790" "1.003" "3.095" "372.4" "346.6" "335.4" "362.7" "367.0" "342.5" "357.7" "294.3" "373.5" "1152.5" "" "" "" "" "" "" "" "" "" "" "330.2" "287.1" "292.6" "271.2" "306.0" "314.6" "302.4" "243.2" "342.5" "1152.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2213964009562645664" "False" "High" "IsMasterProtein" "Q9Y221" "60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1" "0.000" "False" "6.067" "9" "2" "3" "2" "180" "20.4" "8.51" "9.97" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf03657, Pf17833" "51388" "ENSG00000132603" "NIP7" "B2RD04; hsa:51388; Q9NZZ0; Q9Y221" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.850" "0.906" "0.957" "0.977" "1.053" "1.048" "1.117" "0.930" "0.432" "729.7" "620.1" "661.2" "698.6" "713.0" "768.1" "764.4" "815.0" "678.2" "314.9" "" "" "" "" "" "" "" "" "" "" "647.1" "513.7" "576.9" "522.5" "594.5" "705.6" "646.0" "673.7" "622.0" "314.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1892947756111346869" "False" "High" "IsMasterProtein" "P42345" "Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1" "0.000" "False" "6.052" "1" "3" "3" "3" "2549" "288.7" "7.17" "6.70" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08771, Pf11865" "2475" "ENSG00000198793" "MTOR" "hsa:2475; P42345; Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; HSF1-dependent transactivation" "AMP-activated protein kinase signaling; Target of rapamycin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; TSLP signaling pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM signaling in development and disease ; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; CAMKK2 pathway; Neuroinflammation; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Acute myeloid leukemia; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; Interferon type I signaling pathways; ErbB signaling pathway" "92" "0" "0.911" "0.715" "0.905" "0.779" "0.887" "0.814" "0.909" "0.856" "1.313" "109.8" "100.0" "78.5" "99.4" "85.6" "97.3" "89.3" "99.8" "94.0" "144.1" "" "" "" "" "" "" "" "" "" "" "97.3" "82.9" "68.5" "74.3" "71.4" "89.4" "75.5" "82.5" "86.2" "144.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1098177410018711325" "False" "High" "IsMasterProtein" "Q16600" "Zinc finger protein 239 OS=Homo sapiens OX=9606 GN=ZNF239 PE=1 SV=3" "0.000" "False" "6.043" "2" "1" "1" "1" "458" "51.6" "7.64" "4.05" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "8187" "ENSG00000196793" "ZNF239" "hsa:8187; Q16600; Q5T1G9; Q8TAS5" "" "" "0" "0" "0.714" "0.839" "0.865" "0.901" "0.848" "0.838" "0.766" "0.840" "0.854" "118.4" "84.5" "99.4" "102.4" "106.7" "100.4" "99.3" "90.8" "99.5" "101.1" "" "" "" "" "" "" "" "" "" "" "105.0" "70.0" "86.7" "76.6" "89.0" "92.2" "83.9" "75.0" "91.3" "101.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8388783144784420231" "False" "High" "IsMasterProtein" "P82930" "Small ribosomal subunit protein mS34 OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "0.000" "False" "6.042" "10" "3" "3" "3" "218" "25.6" "9.98" "6.75" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.914" "0.953" "0.950" "0.900" "0.718" "1.092" "0.687" "0.768" "4.604" "106.0" "96.9" "101.0" "100.7" "95.4" "76.1" "115.8" "72.8" "81.4" "488.0" "" "" "" "" "" "" "" "" "" "" "94.0" "80.3" "88.2" "75.3" "79.6" "69.9" "97.9" "60.2" "74.7" "488.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638304543600080" "False" "High" "IsMasterProtein" "Q9NZJ7" "Mitochondrial carrier homolog 1 OS=Homo sapiens OX=9606 GN=MTCH1 PE=1 SV=1" "0.000" "False" "6.032" "3" "1" "3" "1" "389" "41.5" "9.32" "9.16" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00153" "23787" "ENSG00000137409" "MTCH1" "A8KAX5; B2RCE3; hsa:23787; Q6PK60; Q6UX45; Q7L465; Q9BW23; Q9NZJ7; Q9NZR6; Q9UJZ5" "" "IL-18 signaling pathway" "1" "0" "1.368" "0.948" "1.015" "1.107" "1.103" "1.130" "1.099" "1.075" "0.200" "276.4" "378.2" "262.1" "280.6" "305.9" "304.8" "312.4" "303.7" "297.3" "55.4" "" "" "" "" "" "" "" "" "" "" "245.1" "313.3" "228.7" "209.8" "255.1" "280.0" "264.0" "251.0" "272.6" "55.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.000" "False" "6.031" "3" "2" "2" "1" "545" "59.4" "6.29" "6.80" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "1.151" "0.966" "0.910" "1.016" "0.905" "1.054" "0.687" "0.923" "5.617" "70.7" "81.4" "68.3" "64.4" "71.8" "64.0" "74.5" "48.5" "65.3" "397.1" "" "" "" "" "" "" "" "" "" "" "62.7" "67.4" "59.6" "48.1" "59.9" "58.8" "63.0" "40.1" "59.9" "397.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4391035290481489503" "False" "High" "IsMasterProtein" "O95147" "Dual specificity protein phosphatase 14 OS=Homo sapiens OX=9606 GN=DUSP14 PE=1 SV=1" "0.000" "False" "6.028" "7" "1" "1" "1" "198" "22.2" "9.57" "4.65" "1" "other metabolic processes" "" "other molecular function" "Pf00782" "11072" "ENSG00000275932; ENSG00000276023" "DUSP14" "hsa:11072; O95147" "" "Hypertrophy model; 17q12 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8871370198028658557" "False" "High" "IsMasterProtein" "P62995" "Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1" "0.000" "False" "6.023" "5" "1" "1" "1" "288" "33.6" "11.25" "4.26" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6434" "ENSG00000136527" "TRA2B" "B4DVK2; D3DNU3; hsa:6434; O15449; P62995; Q15815; Q64283" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "High" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.000" "False" "6.019" "4" "2" "2" "2" "425" "47.6" "6.62" "6.33" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "0.952" "0.941" "1.074" "0.917" "0.954" "1.040" "0.907" "0.792" "2.408" "176.8" "168.3" "166.3" "189.9" "162.0" "168.6" "183.8" "160.4" "140.1" "425.6" "" "" "" "" "" "" "" "" "" "" "156.7" "139.4" "145.1" "142.0" "135.1" "154.9" "155.3" "132.6" "128.4" "425.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022401648324513827" "False" "High" "IsMasterProtein" "Q9H6W3" "Ribosomal oxygenase 1 OS=Homo sapiens OX=9606 GN=RIOX1 PE=1 SV=2" "0.000" "False" "6.010" "2" "1" "1" "1" "641" "71.0" "6.46" "3.89" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf08007, Pf21233" "79697" "ENSG00000170468" "RIOX1" "B4DT02; hsa:79697; Q9H6W3" "Protein hydroxylation" "" "1" "0" "1.212" "1.143" "1.061" "1.278" "0.935" "1.070" "1.079" "1.049" "2.408" "42.7" "51.7" "48.7" "45.3" "54.5" "39.9" "45.6" "46.0" "44.7" "102.7" "" "" "" "" "" "" "" "" "" "" "37.8" "42.8" "42.5" "33.9" "45.5" "36.6" "38.6" "38.0" "41.0" "102.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6311792634323400615" "False" "High" "IsMasterProtein" "Q9NSU2" "Three-prime repair exonuclease 1 OS=Homo sapiens OX=9606 GN=TREX1 PE=1 SV=2" "0.000" "False" "6.000" "6" "2" "3" "2" "314" "33.2" "7.93" "10.34" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "11277" "ENSG00000213689" "TREX1" "B2RCN9; hsa:11277; Q8TEU2; Q9BPW1; Q9NSU2; Q9Y4X2" "IRF3-mediated induction of type I IFN; Regulation by TREX1" "Cytosolic DNA-sensing pathway" "3" "0" "1.052" "1.071" "1.033" "1.130" "0.997" "1.205" "1.155" "1.156" "0.602" "138.3" "145.4" "148.1" "142.8" "156.2" "137.9" "166.6" "159.7" "159.9" "83.2" "" "" "" "" "" "" "" "" "" "" "122.6" "120.5" "129.3" "106.8" "130.3" "126.6" "140.8" "132.0" "146.6" "83.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3995603134814959224" "False" "High" "IsMasterProtein" "Q9NRL2" "Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2" "0.000" "False" "5.977" "1" "2" "2" "2" "1556" "178.6" "6.60" "5.42" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf10537, Pf15612, Pf15613" "11177" "ENSG00000198604" "BAZ1A" "hsa:11177; Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3" "" "Ectoderm differentiation" "1" "0" "1.051" "0.844" "1.085" "0.913" "0.987" "1.022" "0.618" "1.064" "7.426" "126.1" "132.5" "106.4" "136.7" "115.1" "124.4" "128.8" "77.9" "134.1" "936.2" "" "" "" "" "" "" "" "" "" "" "111.8" "109.8" "92.8" "102.3" "96.0" "114.3" "108.9" "64.4" "123.0" "936.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5346990888156719951" "False" "High" "IsMasterProtein" "P48436" "Transcription factor SOX-9 OS=Homo sapiens OX=9606 GN=SOX9 PE=1 SV=1" "0.000" "False" "5.932" "4" "3" "3" "3" "509" "56.1" "6.81" "8.29" "3" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf12444" "6662" "ENSG00000125398" "SOX9" "hsa:6662; P48436; Q53Y80" "Deactivation of the beta-catenin transactivating complex; Transcriptional regulation by RUNX2; Transcriptional regulation of testis differentiation" "Neural crest differentiation; Spinal cord injury; Endochondral ossification; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; Somatic sex determination; Mammalian disorder of sexual development; MAP3K1 role in promoting and blocking gonadal determination; Osteoarthritic chondrocyte hypertrophy; Cell lineage map for neuronal differentiation; Prostaglandin synthesis and regulation" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "5.929" "4" "3" "3" "2" "474" "51.3" "9.41" "9.06" "3" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "1.107" "0.753" "0.843" "0.821" "0.863" "0.839" "0.472" "0.905" "8.780" "166.9" "184.8" "125.7" "140.6" "136.9" "144.0" "140.0" "78.8" "151.0" "1465.0" "" "" "" "" "" "" "" "" "" "" "148.0" "153.0" "109.7" "105.2" "114.2" "132.3" "118.3" "65.2" "138.5" "1465.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064589920710455811" "False" "High" "IsMasterProtein" "O00635" "E3 ubiquitin-protein ligase TRIM38 OS=Homo sapiens OX=9606 GN=TRIM38 PE=1 SV=1" "0.000" "False" "5.916" "3" "1" "2" "1" "465" "53.4" "7.02" "6.38" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "10475" "ENSG00000112343" "TRIM38" "B2R862; hsa:10475; O00635" "Interferon gamma signaling" "" "1" "0" "0.865" "0.716" "0.955" "0.554" "0.704" "0.559" "0.010" "0.903" "24.254" "12.0" "10.4" "8.6" "11.5" "6.7" "8.5" "6.7" "0.0" "10.9" "292.2" "" "" "" "" "" "" "" "" "" "" "10.7" "8.6" "7.5" "8.6" "5.6" "7.8" "5.7" "0.0" "10.0" "292.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7658381107240133843" "False" "High" "IsMasterProtein" "Q5VT06" "Centrosome-associated protein 350 OS=Homo sapiens OX=9606 GN=CEP350 PE=1 SV=1" "0.000" "False" "5.914" "1" "1" "1" "1" "3117" "350.7" "6.33" "3.26" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14309" "9857" "ENSG00000135837" "CEP350" "hsa:9857; O75068; Q5VT06; Q8TDK3; Q8WY20" "" "3q29 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8268221381324165575" "False" "High" "IsMasterProtein" "Q96B96" "Lipid droplet assembly factor 1 OS=Homo sapiens OX=9606 GN=LDAF1 PE=1 SV=2" "0.000" "False" "5.913" "13" "2" "2" "2" "161" "17.5" "5.06" "6.05" "2" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf16015" "57146" "ENSG00000011638" "LDAF1" "A6NMA9; B4DEC1; hsa:57146; O00323; Q96B96" "" "" "0" "0" "1.273" "1.083" "1.490" "1.305" "0.913" "1.260" "1.111" "0.975" "0.651" "203.7" "259.3" "220.5" "303.4" "265.8" "186.0" "256.6" "226.3" "198.6" "132.6" "" "" "" "" "" "" "" "" "" "" "180.6" "214.8" "192.4" "226.9" "221.7" "170.8" "216.9" "187.1" "182.2" "132.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288678854882700202" "False" "High" "IsMasterProtein" "Q7Z3C6" "Autophagy-related protein 9A OS=Homo sapiens OX=9606 GN=ATG9A PE=1 SV=3" "0.000" "False" "5.904" "4" "3" "3" "3" "839" "94.4" "6.67" "4.57" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf04109" "79065" "ENSG00000198925" "ATG9A" "hsa:79065; Q3ZAQ6; Q6P0N7; Q7Z317; Q7Z320; Q7Z3C6; Q8NDK6; Q8WU65; Q9BVL5; Q9H6L1; Q9HAG7" "Macroautophagy" "Autophagy; Primary ovarian insufficiency" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2992293195289622245" "False" "High" "IsMasterProtein" "Q15005" "Signal peptidase complex subunit 2 OS=Homo sapiens OX=9606 GN=SPCS2 PE=1 SV=3" "0.000" "False" "5.887" "10" "1" "1" "1" "226" "25.0" "8.47" "3.16" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "" "Pf06703" "9789" "ENSG00000118363" "SPCS2" "hsa:9789; Q15005; Q15507; Q3KQT0; Q641R4; Q6FG65; Q6IRX0; Q6P1P4; Q96HU9" "SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Maturation of hRSV A proteins; Synthesis, secretion, and deacylation of Ghrelin" "15q25 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "Not Found" "High" "High" "Not Found" "High" "High" "High" "Not Found" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.000" "False" "5.878" "2" "1" "1" "1" "631" "73.9" "6.05" "4.13" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "" "4" "0" "0.981" "0.803" "0.893" "0.935" "0.885" "0.802" "0.305" "0.890" "9.131" "101.5" "99.5" "81.5" "90.6" "94.8" "89.8" "81.4" "30.9" "90.3" "926.4" "" "" "" "" "" "" "" "" "" "" "90.0" "82.5" "71.1" "67.7" "79.1" "82.5" "68.8" "25.6" "82.8" "926.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1191558879901855152" "False" "High" "IsMasterProtein" "O15213" "WD repeat-containing protein 46 OS=Homo sapiens OX=9606 GN=WDR46 PE=1 SV=3" "0.000" "False" "5.851" "2" "2" "2" "2" "610" "68.0" "9.67" "6.46" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf08149" "9277" "ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222" "WDR46" "A6NDP5; hsa:9277; O15213; Q5HYZ0; Q5STK5; Q5STR3" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.969" "0.915" "0.968" "0.958" "1.034" "0.764" "0.754" "0.765" "0.627" "257.8" "249.7" "235.8" "249.6" "247.0" "266.7" "196.9" "194.3" "197.2" "161.6" "" "" "" "" "" "" "" "" "" "" "228.6" "206.8" "205.7" "186.7" "206.0" "245.0" "166.4" "160.6" "180.9" "161.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "High" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.000" "False" "5.849" "2" "2" "2" "2" "1093" "119.7" "7.66" "6.90" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "0.887" "0.838" "0.984" "0.801" "0.883" "0.899" "0.745" "0.859" "4.375" "253.8" "225.1" "212.6" "249.7" "203.3" "224.1" "228.1" "189.1" "217.9" "1110.2" "" "" "" "" "" "" "" "" "" "" "225.0" "186.5" "185.5" "186.8" "169.5" "205.9" "192.8" "156.3" "199.9" "1110.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457193127181059495" "False" "High" "IsMasterProtein" "Q8TDR0" "TRAF3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TRAF3IP1 PE=1 SV=1" "0.000" "False" "5.827" "2" "1" "1" "1" "691" "78.6" "7.93" "4.84" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf10243, Pf17749" "26146" "ENSG00000204104" "TRAF3IP1" "hsa:26146; Q6PCT1; Q7L8N9; Q8TDR0; Q9NRD6; Q9Y4Q1" "Intraflagellar transport" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 2q37 copy number variation syndrome; Bardet-Biedl syndrome" "6" "0" "0.901" "0.642" "0.817" "0.588" "0.533" "0.592" "0.564" "0.605" "1.074" "51.2" "46.2" "32.9" "41.9" "30.1" "27.3" "30.3" "28.9" "31.0" "55.1" "" "" "" "" "" "" "" "" "" "" "45.4" "38.3" "28.7" "31.3" "25.1" "25.1" "25.6" "23.9" "28.4" "55.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5038635126872872861" "False" "High" "IsMasterProtein" "O15015" "Zinc finger protein 646 OS=Homo sapiens OX=9606 GN=ZNF646 PE=1 SV=2" "0.000" "False" "5.821" "3" "3" "5" "3" "1832" "200.7" "7.21" "10.71" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "9726" "ENSG00000167395" "ZNF646" "hsa:9726; O15015; Q8IVD8" "" "" "0" "0" "1.046" "0.959" "0.950" "0.731" "0.752" "0.856" "0.844" "0.960" "0.568" "26.1" "27.2" "25.0" "24.8" "19.1" "19.6" "22.3" "22.0" "25.0" "14.8" "" "" "" "" "" "" "" "" "" "" "23.1" "22.6" "21.8" "18.5" "15.9" "18.0" "18.8" "18.2" "22.9" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6164740202733872267" "False" "High" "IsMasterProtein" "P05107" "Integrin beta-2 OS=Homo sapiens OX=9606 GN=ITGB2 PE=1 SV=3" "0.000" "False" "5.805" "2" "2" "2" "2" "769" "84.7" "6.98" "6.14" "2" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00362, Pf07965, Pf08725, Pf17205" "3689" "ENSG00000160255" "ITGB2" "B3KTS8; D3DSM1; hsa:3689; P05107; Q16418; Q53HS5; Q9UD72" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; Toll Like Receptor 4 (TLR4) Cascade; Interleukin-4 and Interleukin-13 signaling" "Integrin-mediated cell adhesion; Complement system; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia; Fibrin complement receptor 3 signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "20" "0" "1.210" "1.092" "1.168" "1.186" "1.300" "1.179" "1.220" "1.389" "0.839" "235.9" "285.5" "257.7" "275.7" "279.9" "306.8" "278.2" "287.9" "327.6" "197.9" "" "" "" "" "" "" "" "" "" "" "209.2" "236.5" "224.8" "206.2" "233.4" "281.9" "235.1" "238.0" "300.5" "197.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9045329245485250049" "False" "High" "IsMasterProtein" "Q9BW66" "Cyclin-dependent kinase 2-interacting protein OS=Homo sapiens OX=9606 GN=CINP PE=1 SV=1" "0.000" "False" "5.801" "5" "1" "2" "1" "212" "24.3" "6.28" "6.34" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "" "51550" "ENSG00000100865" "CINP" "F5H7P3; F5H8A7; hsa:51550; Q9BW66; Q9NPF9" "" "" "0" "0" "1.101" "1.035" "1.019" "1.095" "1.060" "0.986" "1.291" "1.218" "0.954" "52.6" "57.9" "54.5" "53.6" "57.6" "55.8" "51.9" "67.9" "64.1" "50.2" "" "" "" "" "" "" "" "" "" "" "46.6" "48.0" "47.5" "40.1" "48.0" "51.2" "43.9" "56.2" "58.8" "50.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "334815564542611035" "False" "High" "IsMasterProtein" "Q9BTF0" "THUMP domain-containing protein 2 OS=Homo sapiens OX=9606 GN=THUMPD2 PE=1 SV=2" "0.000" "False" "5.796" "3" "2" "2" "2" "503" "56.4" "7.81" "6.42" "2" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "80745" "ENSG00000138050" "THUMPD2" "A8K7I7; hsa:80745; Q53TT8; Q53TV0; Q9BTF0" "" "" "0" "0" "1.173" "0.897" "0.955" "0.830" "0.877" "1.117" "1.159" "1.104" "0.589" "84.9" "99.6" "76.1" "81.0" "70.5" "74.5" "94.8" "98.4" "93.7" "50.0" "" "" "" "" "" "" "" "" "" "" "75.3" "82.5" "66.4" "60.6" "58.8" "68.4" "80.1" "81.3" "86.0" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6374027858147592096" "False" "High" "IsMasterProtein" "O95613" "Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4" "0.000" "False" "5.792" "1" "3" "3" "3" "3336" "377.8" "5.55" "7.69" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton" "other molecular function" "Pf10495" "5116" "ENSG00000160299" "PCNT" "hsa:5116; O43152; O95613; Q7Z7C9" "Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy" "" "10" "0" "0.840" "0.811" "0.913" "0.723" "0.731" "0.657" "0.740" "0.696" "1.583" "174.5" "146.7" "141.5" "159.3" "126.2" "127.6" "114.6" "129.1" "121.5" "276.3" "" "" "" "" "" "" "" "" "" "" "154.8" "121.5" "123.5" "119.1" "105.3" "117.2" "96.9" "106.7" "111.4" "276.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660513057168003161" "False" "High" "IsMasterProtein" "Q99805" "Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1" "0.000" "False" "5.790" "2" "1" "1" "1" "663" "75.7" "7.44" "5.68" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9375" "ENSG00000125304" "TM9SF2" "A8K399; hsa:9375; Q2TAY5; Q99805" "" "" "0" "0" "1.088" "0.910" "0.830" "0.918" "1.103" "1.154" "1.078" "1.116" "0.819" "133.9" "145.7" "121.9" "111.2" "123.0" "147.7" "154.6" "144.4" "149.5" "109.7" "" "" "" "" "" "" "" "" "" "" "118.8" "120.7" "106.3" "83.2" "102.5" "135.7" "130.7" "119.3" "137.1" "109.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2299489419539549984" "False" "High" "IsMasterProtein" "Q9HCE3" "Zinc finger protein 532 OS=Homo sapiens OX=9606 GN=ZNF532 PE=1 SV=2" "0.000" "False" "5.788" "2" "2" "2" "2" "1301" "141.6" "8.65" "5.90" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13912, Pf16622" "55205" "ENSG00000074657" "ZNF532" "hsa:55205; Q4G0V6; Q7L7Z7; Q96QR7; Q9HCE3; Q9NVJ6" "" "" "0" "0" "1.002" "1.048" "0.944" "1.128" "1.075" "1.009" "1.054" "1.050" "0.231" "254.7" "255.1" "266.9" "240.3" "287.2" "273.9" "257.0" "268.5" "267.3" "58.8" "" "" "" "" "" "" "" "" "" "" "225.8" "211.3" "232.9" "179.7" "239.5" "251.6" "217.2" "221.9" "245.2" "58.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6839328025786412068" "False" "High" "IsMasterProtein" "Q13438" "Protein OS-9 OS=Homo sapiens OX=9606 GN=OS9 PE=1 SV=1" "0.000" "False" "5.783" "2" "1" "1" "1" "667" "75.5" "4.87" "3.77" "1" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf07915" "10956" "ENSG00000135506" "OS9" "A6NDD1; A6NFR7; A6NLB2; A8K5Q9; B4DE28; B4DPX1; B4E1I6; E7ENT8; E7EW91; F8VUH2; G3XA88; hsa:10956; O00579; Q13438; Q6IBL2; Q8IZ58; Q9BW99" "ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5612646896286873908" "False" "High" "IsMasterProtein" "Q6PJG2" "Mitotic deacetylase-associated SANT domain protein OS=Homo sapiens OX=9606 GN=MIDEAS PE=1 SV=2" "0.000" "False" "5.769" "3" "3" "3" "3" "1045" "114.9" "9.19" "5.50" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01448" "91748" "ENSG00000156030" "MIDEAS" "hsa:91748; Q6PJG2; Q6PK13; Q6PK59; Q6ZS23" "" "" "0" "0" "0.951" "0.738" "0.975" "0.782" "0.909" "0.882" "0.779" "0.889" "0.802" "25.9" "24.6" "19.1" "25.2" "20.3" "23.5" "22.8" "20.2" "23.0" "20.8" "" "" "" "" "" "" "" "" "" "" "23.0" "20.4" "16.7" "18.9" "16.9" "21.6" "19.3" "16.7" "21.1" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5989449772678294207" "False" "High" "IsMasterProtein" "Q96JA1" "Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Homo sapiens OX=9606 GN=LRIG1 PE=1 SV=2" "0.000" "False" "5.764" "3" "2" "3" "2" "1093" "119.0" "7.09" "8.63" "2" "developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes" "" "Pf01463, Pf07679, Pf12799, Pf13855, Pf13927" "26018" "ENSG00000144749" "LRIG1" "hsa:26018; Q6IQ51; Q96CF9; Q96JA1; Q9BYB8; Q9UFI4" "Signaling by EGFR; Negative regulation of MET activity" "GDNF signaling" "3" "0" "0.937" "0.859" "0.960" "0.709" "0.887" "0.896" "0.904" "0.916" "0.628" "87.7" "82.1" "75.3" "84.2" "62.1" "77.8" "78.6" "79.3" "80.3" "55.1" "" "" "" "" "" "" "" "" "" "" "77.7" "68.0" "65.7" "62.9" "51.8" "71.4" "66.4" "65.5" "73.6" "55.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4132894950803344726" "False" "High" "IsMasterProtein" "Q96KQ4" "Apoptosis-stimulating of p53 protein 1 OS=Homo sapiens OX=9606 GN=PPP1R13B PE=1 SV=3" "0.000" "False" "5.763" "1" "1" "1" "1" "1090" "119.5" "6.76" "4.61" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00018, Pf00023, Pf21801" "23368" "ENSG00000088808" "PPP1R13B" "B2RMX5; hsa:23368; O94870; Q96KQ4" "TP53 Regulates Transcription of Death Receptors and Ligands; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors" "" "5" "0" "1.303" "1.235" "0.778" "0.853" "1.081" "0.788" "0.786" "1.089" "0.792" "14.6" "19.0" "18.1" "11.4" "12.5" "15.8" "11.5" "11.5" "15.9" "11.6" "" "" "" "" "" "" "" "" "" "" "13.0" "15.8" "15.8" "8.5" "10.4" "14.5" "9.7" "9.5" "14.6" "11.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972887412222597887" "False" "High" "IsMasterProtein" "Q9UIS9" "Methyl-CpG-binding domain protein 1 OS=Homo sapiens OX=9606 GN=MBD1 PE=1 SV=2" "0.000" "False" "5.760" "2" "1" "1" "1" "605" "66.6" "9.04" "3.33" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf02008" "4152" "ENSG00000141644" "MBD1" "A4UTZ0; B4DXJ5; E9PEC5; hsa:4152; K7ELI2; K7EQZ4; K7ESN0; O15248; O95241; Q7Z7B5; Q8N4W4; Q9UIS9; Q9UNZ6; Q9UNZ7; Q9UNZ8; Q9UNZ9" "SUMOylation of transcription cofactors" "Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "0" "1.026" "0.929" "0.997" "0.868" "0.766" "0.792" "0.987" "0.893" "1.160" "81.8" "83.9" "75.9" "81.5" "71.0" "62.6" "64.7" "80.7" "73.1" "94.9" "" "" "" "" "" "" "" "" "" "" "72.5" "69.5" "66.3" "61.0" "59.2" "57.5" "54.7" "66.7" "67.0" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9146953398004624321" "False" "High" "IsMasterProtein" "Q00613" "Heat shock factor protein 1 OS=Homo sapiens OX=9606 GN=HSF1 PE=1 SV=1" "0.000" "False" "5.754" "3" "2" "2" "2" "529" "57.2" "5.19" "5.94" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00447, Pf06546" "3297" "ENSG00000185122; ENSG00000284774" "HSF1" "A8K4L0; A8MW26; hsa:3297; Q00613; Q53XT4" "Regulation of HSF1-mediated heat shock response; Attenuation phase; Aggrephagy; HSF1 activation" "10q11.21q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "7" "0" "0.947" "0.887" "0.945" "0.816" "0.886" "0.953" "0.517" "0.798" "6.372" "185.2" "175.4" "164.3" "174.9" "151.1" "164.1" "176.4" "95.7" "147.8" "1180.1" "" "" "" "" "" "" "" "" "" "" "164.2" "145.3" "143.4" "130.8" "126.0" "150.8" "149.1" "79.1" "135.6" "1180.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5366408655713326940" "False" "High" "IsMasterProtein" "Q07817" "Bcl-2-like protein 1 OS=Homo sapiens OX=9606 GN=BCL2L1 PE=1 SV=1" "0.000" "False" "5.749" "4" "1" "1" "1" "233" "26.0" "4.93" "4.30" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00452, Pf02180" "598" "ENSG00000171552" "BCL2L1" "E1P5L6; hsa:598; Q07817; Q5CZ89; Q5TE65; Q92976" "Interleukin-4 and Interleukin-13 signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; RAS processing; NFE2L2 regulating tumorigenic genes; The NLRP1 inflammasome; STAT5 activation downstream of FLT3 ITD mutants; SARS-CoV-1-mediated effects on programmed cell death" "Leptin signaling pathway; IL-7 signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); IL-3 signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; lncRNA-mediated mechanisms of therapeutic resistance; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis" "32" "0" "1.136" "1.193" "1.142" "1.383" "1.364" "1.054" "1.127" "1.158" "0.889" "109.6" "124.5" "130.8" "125.3" "151.7" "149.5" "115.6" "123.6" "127.0" "97.5" "" "" "" "" "" "" "" "" "" "" "97.2" "103.2" "114.1" "93.7" "126.5" "137.3" "97.7" "102.2" "116.4" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3509057874585176951" "False" "High" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "0.000" "False" "5.746" "6" "3" "3" "3" "419" "47.2" "8.94" "8.29" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "9" "0" "0.881" "0.899" "0.970" "0.892" "0.852" "0.960" "0.233" "0.841" "10.782" "63.7" "56.1" "57.2" "61.7" "56.8" "54.3" "61.1" "14.9" "53.5" "686.6" "" "" "" "" "" "" "" "" "" "" "56.5" "46.5" "49.9" "46.2" "47.4" "49.8" "51.6" "12.3" "49.1" "686.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4903431523093654151" "False" "High" "IsMasterProtein" "A0A0B4J2F0" "Protein PIGBOS1 OS=Homo sapiens OX=9606 GN=PIGBOS1 PE=1 SV=1" "0.000" "False" "5.741" "19" "1" "1" "1" "54" "6.3" "8.50" "4.64" "1" "stress response;other biological processes" "other membranes;mitochondrion" "" "" "101928527" "ENSG00000225973" "PIGBOS1" "A0A0B4J2F0; hsa:101928527" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7513240538999229112" "False" "High" "IsMasterProtein" "O95136" "Sphingosine 1-phosphate receptor 2 OS=Homo sapiens OX=9606 GN=S1PR2 PE=1 SV=2" "0.000" "False" "5.740" "3" "1" "1" "1" "353" "38.8" "8.97" "4.24" "1" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00001" "9294" "ENSG00000267534" "S1PR2" "hsa:9294; O95136; Q86UN8" "G alpha (i) signalling events; Lysosphingolipid and LPA receptors" "Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence" "5" "0" "1.177" "0.972" "1.290" "1.286" "1.150" "1.083" "1.053" "1.201" "1.481" "104.1" "122.5" "101.2" "134.3" "133.9" "119.7" "112.7" "109.7" "125.1" "154.2" "" "" "" "" "" "" "" "" "" "" "92.3" "101.5" "88.3" "100.4" "111.7" "110.0" "95.3" "90.7" "114.7" "154.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.000" "False" "5.740" "3" "1" "1" "1" "572" "61.8" "7.09" "4.19" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "CRMPs in Sema3A signaling" "" "1" "0" "1.151" "1.060" "1.123" "1.176" "1.000" "1.080" "1.121" "1.065" "0.593" "152.1" "175.1" "161.3" "170.8" "178.8" "152.1" "164.2" "170.4" "162.0" "90.2" "" "" "" "" "" "" "" "" "" "" "134.9" "145.0" "140.7" "127.8" "149.1" "139.7" "138.8" "140.9" "148.5" "90.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4095245218614045361" "False" "High" "IsMasterProtein" "Q96D96" "Voltage-gated hydrogen channel 1 OS=Homo sapiens OX=9606 GN=HVCN1 PE=1 SV=1" "0.000" "False" "5.739" "5" "1" "1" "1" "273" "31.7" "6.80" "4.68" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00520, Pf16799" "84329" "ENSG00000122986" "HVCN1" "A8MQ37; B4DEB3; F8WCH5; hsa:84329; Q6UW11; Q96D96; Q96IS5" "Neutrophil degranulation; Sperm Motility And Taxes; ROS and RNS production in phagocytes" "" "3" "0" "1.142" "1.060" "1.203" "1.348" "1.206" "1.456" "1.201" "1.451" "1.559" "91.9" "104.9" "97.5" "110.6" "123.9" "110.8" "133.8" "110.4" "133.4" "143.3" "" "" "" "" "" "" "" "" "" "" "81.5" "86.9" "85.0" "82.7" "103.3" "101.8" "113.1" "91.2" "122.3" "143.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6582781220812182564" "False" "High" "IsMasterProtein" "Q9NX70" "Mediator of RNA polymerase II transcription subunit 29 OS=Homo sapiens OX=9606 GN=MED29 PE=1 SV=1" "0.000" "False" "5.730" "14" "3" "3" "3" "200" "21.1" "6.29" "8.87" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11568" "55588" "ENSG00000063322" "MED29" "B4DNQ6; hsa:55588; M0R2E4; Q5XX09; Q9NTF4; Q9NX70" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "1.017" "0.903" "0.836" "0.739" "0.729" "0.714" "0.713" "0.916" "1.908" "437.9" "445.4" "395.4" "366.2" "323.5" "319.0" "312.7" "312.2" "400.9" "835.5" "" "" "" "" "" "" "" "" "" "" "388.3" "368.9" "345.0" "273.9" "269.8" "293.1" "264.3" "258.1" "367.7" "835.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-984434890743612814" "False" "High" "IsMasterProtein" "Q96A57" "Transmembrane protein 230 OS=Homo sapiens OX=9606 GN=TMEM230 PE=1 SV=1" "0.000" "False" "5.726" "9" "1" "1" "1" "120" "13.2" "9.31" "3.96" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf05915" "29058" "ENSG00000089063" "TMEM230" "B2RDM8; D3DVZ9; hsa:29058; Q0VGC8; Q5TDS5; Q96A57; Q96ES2; Q9P0A7" "" "" "0" "0" "1.082" "1.016" "1.088" "1.093" "1.149" "1.067" "1.019" "1.102" "0.881" "257.2" "278.2" "261.3" "279.8" "281.1" "295.5" "274.4" "262.0" "283.4" "226.5" "" "" "" "" "" "" "" "" "" "" "228.1" "230.4" "228.0" "209.2" "234.4" "271.4" "231.9" "216.6" "259.9" "226.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "High" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.000" "False" "5.716" "1" "2" "2" "2" "1290" "148.4" "6.05" "6.25" "2" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "ISG15 antiviral mechanism; Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "76" "0" "0.802" "0.686" "0.774" "0.816" "0.647" "0.704" "0.244" "0.790" "8.585" "116.7" "93.6" "80.1" "90.3" "95.2" "75.5" "82.2" "28.5" "92.2" "1002.2" "" "" "" "" "" "" "" "" "" "" "103.5" "77.5" "69.9" "67.6" "79.4" "69.4" "69.5" "23.6" "84.6" "1002.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7554911446023016001" "False" "High" "IsMasterProtein" "P51668" "Ubiquitin-conjugating enzyme E2 D1 OS=Homo sapiens OX=9606 GN=UBE2D1 PE=1 SV=1" "0.000" "False" "5.716" "12" "2" "2" "2" "147" "16.6" "7.42" "7.30" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7321" "ENSG00000072401" "UBE2D1" "A6NLF6; A8K786; hsa:7321; P51668" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Peroxisomal protein import; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CLEC7A (Dectin-1) signaling; CDK-mediated phosphorylation and removal of Cdc6; Neddylation; IKK complex recruitment mediated by RIP1; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Signaling by BMP; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ovarian tumor domain proteases" "Proteasome degradation" "35" "0" "1.178" "0.895" "1.080" "1.149" "1.119" "1.206" "0.837" "0.950" "4.748" "144.8" "170.7" "129.6" "156.4" "166.3" "162.1" "174.7" "121.2" "137.5" "687.5" "" "" "" "" "" "" "" "" "" "" "128.4" "141.4" "113.1" "117.0" "138.7" "148.9" "147.7" "100.2" "126.1" "687.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5337337969812089768" "False" "High" "IsMasterProtein" "P29374" "AT-rich interactive domain-containing protein 4A OS=Homo sapiens OX=9606 GN=ARID4A PE=1 SV=3" "0.000" "False" "5.705" "1" "1" "1" "1" "1257" "142.7" "5.10" "3.36" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf01388, Pf08169, Pf11717" "5926" "ENSG00000032219" "ARID4A" "hsa:5926; P29374; Q15991; Q15992; Q15993" "Potential therapeutics for SARS; HDACs deacetylate histones" "" "2" "0" "0.939" "0.912" "1.105" "1.121" "0.978" "1.025" "1.019" "1.027" "2.932" "89.8" "84.3" "81.8" "99.2" "100.7" "87.8" "92.0" "91.5" "92.2" "263.2" "" "" "" "" "" "" "" "" "" "" "79.6" "69.8" "71.4" "74.2" "83.9" "80.7" "77.8" "75.6" "84.6" "263.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5818593354028515611" "False" "High" "IsMasterProtein" "P56524" "Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3" "0.000" "False" "5.699" "3" "3" "3" "2" "1084" "119.0" "6.96" "8.27" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "9759" "ENSG00000068024" "HDAC4" "E9PGB9; F5GX36; hsa:9759; P56524; Q86YH7; Q9UND6" "SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of intracellular receptors; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX3 regulates p14-ARF; RUNX2 regulates chondrocyte maturation" "MicroRNAs in cardiomyocyte hypertrophy; Genes targeted by miRNAs in adipocytes; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; 2q37 copy number variation syndrome" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2103706040263496720" "False" "High" "IsMasterProtein" "Q86YH6" "All trans-polyprenyl-diphosphate synthase PDSS2 OS=Homo sapiens OX=9606 GN=PDSS2 PE=1 SV=2" "0.000" "False" "5.691" "5" "2" "2" "2" "399" "44.1" "8.24" "5.68" "2" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00348" "57107" "ENSG00000164494" "PDSS2" "hsa:57107; Q33DR4; Q4G158; Q5VU38; Q5VU39; Q86YH6; Q9NR58" "Ubiquinol biosynthesis" "Nephrotic syndrome" "2" "0" "0.953" "0.931" "1.062" "0.918" "1.190" "1.045" "1.075" "1.014" "0.596" "158.7" "151.2" "147.7" "168.5" "145.7" "188.7" "165.8" "170.6" "160.9" "94.6" "" "" "" "" "" "" "" "" "" "" "140.7" "125.2" "128.9" "126.0" "121.5" "173.4" "140.2" "141.0" "147.6" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6520488725459532506" "False" "High" "IsMasterProtein" "Q96AG3" "Mitochondrial outer membrane protein SLC25A46 OS=Homo sapiens OX=9606 GN=SLC25A46 PE=1 SV=1" "0.000" "False" "5.676" "3" "1" "1" "1" "418" "46.1" "7.43" "3.82" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00153" "91137" "ENSG00000164209" "SLC25A46" "A8K2F2; B3KRE6; B4DTA3; D3DSZ6; D6R9W7; hsa:91137; Q04197; Q96AG3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8713380436033100522" "False" "High" "IsMasterProtein" "Q71SY5" "Mediator of RNA polymerase II transcription subunit 25 OS=Homo sapiens OX=9606 GN=MED25 PE=1 SV=2" "0.000" "False" "5.664" "4" "3" "3" "3" "747" "78.1" "8.34" "6.12" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11232, Pf11235, Pf11265" "81857" "ENSG00000104973" "MED25" "A8K095; B9TX30; hsa:81857; O95783; Q6P143; Q6QMH5; Q707U4; Q71SY5; Q8TB55; Q9H0L5; Q9HB34" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "4" "0" "1.009" "1.008" "1.085" "1.084" "0.979" "1.036" "0.911" "0.960" "1.517" "130.6" "131.7" "131.6" "141.7" "141.5" "127.9" "135.2" "118.9" "125.3" "198.0" "" "" "" "" "" "" "" "" "" "" "115.8" "109.1" "114.8" "106.0" "118.0" "117.5" "114.3" "98.3" "114.9" "198.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4791788072284182717" "False" "High" "IsMasterProtein" "Q96GM5" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2" "0.000" "False" "5.653" "3" "1" "1" "1" "515" "58.2" "9.25" "4.81" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02201" "6602" "ENSG00000066117" "SMARCD1" "A6NN27; hsa:6602; Q92924; Q96GM5; Q9Y635" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "0.726" "1.041" "1.046" "0.800" "1.062" "1.190" "1.186" "1.331" "2.247" "24.9" "18.1" "25.9" "26.1" "19.9" "26.5" "29.7" "29.6" "33.2" "56.0" "" "" "" "" "" "" "" "" "" "" "22.1" "15.0" "22.6" "19.5" "16.6" "24.3" "25.1" "24.4" "30.4" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225000128541682863" "False" "High" "IsMasterProtein" "Q99836" "Myeloid differentiation primary response protein MyD88 OS=Homo sapiens OX=9606 GN=MYD88 PE=1 SV=1" "0.000" "False" "5.640" "6" "2" "2" "2" "296" "33.2" "6.15" "6.90" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf13676" "4615" "ENSG00000172936" "MYD88" "B4DKH8; B4DKU4; B4DQ60; B4DQ72; hsa:4615; J3KPU4; J3KQ87; J3KQJ6; P78397; Q53XS7; Q99836" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; ER-Phagosome pathway; Interleukin-1 signaling; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; MyD88 deficiency (TLR5); IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; IL1 and megakaryocytes in obesity; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; MYD88 distinct input-output pathway; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; HDAC6 interactions in the central nervous system; Toll-like receptor signaling pathway" "35" "0" "1.136" "0.773" "1.000" "0.897" "0.969" "0.987" "0.363" "0.864" "7.804" "95.6" "108.6" "73.9" "95.6" "85.8" "92.7" "94.4" "34.7" "82.6" "746.1" "" "" "" "" "" "" "" "" "" "" "84.8" "90.0" "64.5" "71.5" "71.5" "85.1" "79.8" "28.7" "75.7" "746.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8718473415120973367" "False" "High" "IsMasterProtein" "O00462" "Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3" "0.000" "False" "5.626" "3" "3" "4" "2" "879" "100.8" "5.52" "10.28" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf02836, Pf17753, Pf17786" "4126" "ENSG00000109323" "MANBA" "hsa:4126; O00462; Q96BC3; Q9NYX9" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "" "2" "0" "0.876" "0.920" "1.214" "1.191" "0.709" "1.102" "1.018" "0.873" "0.785" "44.4" "38.9" "40.9" "53.9" "52.9" "31.5" "48.9" "45.2" "38.8" "34.8" "" "" "" "" "" "" "" "" "" "" "39.4" "32.2" "35.7" "40.3" "44.1" "28.9" "41.4" "37.4" "35.5" "34.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717831225161761415" "False" "High" "IsMasterProtein" "P46100" "Transcriptional regulator ATRX OS=Homo sapiens OX=9606 GN=ATRX PE=1 SV=6" "0.000" "False" "5.622" "1" "2" "2" "2" "2492" "282.4" "6.55" "5.43" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf17981" "546" "ENSG00000085224" "ATRX" "D3DTE2; P46100; P51068; Q15886; Q59FB5; Q59H31; Q5H9A2; Q5JWI4; Q7Z2J1; Q9H0Z1; Q9NTS3" "Inhibition of DNA recombination at telomere; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "Pathways affected in adenoid cystic carcinoma" "4" "0" "1.046" "0.954" "1.091" "1.024" "1.129" "1.003" "0.973" "0.922" "1.282" "54.2" "56.7" "51.8" "59.2" "55.5" "61.3" "54.4" "52.8" "50.0" "69.5" "" "" "" "" "" "" "" "" "" "" "48.1" "47.0" "45.2" "44.3" "46.3" "56.3" "46.0" "43.6" "45.9" "69.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155528844813379728" "False" "High" "IsMasterProtein" "Q68CZ2" "Tensin-3 OS=Homo sapiens OX=9606 GN=TNS3 PE=1 SV=2" "0.000" "False" "5.610" "1" "1" "1" "1" "1445" "155.2" "6.81" "3.55" "1" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00017, Pf08416, Pf10409" "64759" "ENSG00000136205" "TNS3" "B2RNV1; hsa:64759; Q68CZ2; Q6IPQ2; Q8IZW7; Q8NAD0; Q96PE0; Q96S48" "MET interacts with TNS proteins" "" "1" "0" "0.947" "0.989" "1.161" "0.957" "1.010" "1.047" "0.685" "0.956" "6.078" "72.8" "69.0" "72.0" "84.5" "69.7" "73.6" "76.2" "49.9" "69.6" "442.5" "" "" "" "" "" "" "" "" "" "" "64.6" "57.1" "62.8" "63.2" "58.1" "67.6" "64.4" "41.2" "63.8" "442.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2014587900474496052" "False" "High" "IsMasterProtein" "Q9P015" "Large ribosomal subunit protein uL15m OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "0.000" "False" "5.596" "6" "2" "3" "2" "296" "33.4" "10.01" "8.44" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "546158601093739992" "False" "High" "IsMasterProtein" "Q8N9V3" "WD repeat, SAM and U-box domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDSUB1 PE=1 SV=4" "0.000" "False" "5.590" "5" "2" "2" "2" "476" "52.8" "6.37" "6.02" "2" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf00400, Pf04564, Pf07647" "151525" "ENSG00000196151" "WDSUB1" "hsa:151525; Q53TI9; Q8N6N8; Q8N9V3" "" "" "0" "0" "1.193" "1.031" "1.248" "1.134" "1.312" "1.041" "1.049" "1.122" "0.595" "17.2" "20.5" "17.7" "21.5" "19.5" "22.6" "17.9" "18.0" "19.3" "10.2" "" "" "" "" "" "" "" "" "" "" "15.3" "17.0" "15.5" "16.1" "16.3" "20.7" "15.1" "14.9" "17.7" "10.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8653500297928283924" "False" "High" "IsMasterProtein" "Q9H7Z3" "Nuclear exosome regulator NRDE2 OS=Homo sapiens OX=9606 GN=NRDE2 PE=1 SV=3" "0.000" "False" "5.574" "2" "1" "1" "1" "1164" "132.6" "7.68" "3.22" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08424" "55051" "ENSG00000119720" "NRDE2" "B4DH71; hsa:55051; Q4G0A7; Q9H7Z3; Q9NWH6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "1" "" "8819989402744158112" "False" "High" "IsMasterProtein" "Q96EW2" "HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1" "0.000" "False" "5.565" "3" "2" "3" "2" "488" "55.1" "5.60" "8.04" "2" "" "other cell component" "other molecular function" "Pf13621" "79663" "ENSG00000169087" "HSPBAP1" "hsa:79663; Q6P476; Q8N8J4; Q8NHH6; Q8WWF0; Q96EW2" "" "" "0" "0" "0.858" "0.763" "0.887" "0.765" "0.989" "1.152" "1.004" "1.100" "1.138" "120.5" "103.4" "92.0" "106.9" "92.1" "119.2" "138.8" "121.1" "132.6" "137.2" "" "" "" "" "" "" "" "" "" "" "106.9" "85.6" "80.3" "79.9" "76.8" "109.5" "117.3" "100.1" "121.6" "137.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8867996448924802282" "False" "High" "IsMasterProtein" "O43255" "E3 ubiquitin-protein ligase SIAH2 OS=Homo sapiens OX=9606 GN=SIAH2 PE=1 SV=1" "0.000" "False" "5.556" "5" "2" "2" "2" "324" "34.6" "7.12" "5.42" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03145, Pf21361, Pf21362" "6478" "ENSG00000181788" "SIAH2" "hsa:6478; O43255; O43270" "Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; Ub-specific processing proteases; Netrin-1 signaling" "Parkin-ubiquitin proteasomal system pathway; Endoderm differentiation; VEGFA-VEGFR2 signaling" "7" "0" "1.061" "0.989" "1.057" "1.023" "1.034" "0.928" "0.889" "0.954" "0.672" "248.0" "263.1" "245.3" "262.1" "253.7" "256.3" "230.1" "220.6" "236.7" "166.7" "" "" "" "" "" "" "" "" "" "" "219.9" "217.9" "214.1" "196.0" "211.5" "235.4" "194.5" "182.3" "217.1" "166.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3859888159614048527" "False" "High" "IsMasterProtein" "Q9NRP4" "Succinate dehydrogenase assembly factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1" "0.000" "False" "5.555" "7" "1" "2" "1" "125" "14.6" "9.07" "7.02" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "mitochondrion" "" "Pf13233" "57001" "ENSG00000196636" "SDHAF3" "A4D1J3; hsa:57001; Q75MD6; Q9NRP4" "" "Mitochondrial complex II assembly" "1" "0" "0.893" "0.886" "0.820" "0.911" "0.908" "0.969" "0.932" "0.927" "0.620" "175.7" "157.0" "155.6" "144.2" "160.1" "159.6" "170.3" "163.7" "162.9" "108.9" "" "" "" "" "" "" "" "" "" "" "155.8" "130.0" "135.8" "107.8" "133.5" "146.6" "143.9" "135.3" "149.4" "108.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1126668279084605329" "False" "High" "IsMasterProtein" "Q96AQ6" "Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Homo sapiens OX=9606 GN=PBXIP1 PE=1 SV=1" "0.000" "False" "5.551" "2" "2" "2" "2" "731" "80.6" "5.33" "6.32" "2" "cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "57326" "ENSG00000163346" "PBXIP1" "hsa:57326; Q5T174; Q5T176; Q96AQ6; Q9H8X6; Q9HA02; Q9HD85" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.959" "0.990" "1.049" "0.918" "0.931" "0.998" "1.022" "0.986" "0.432" "358.1" "343.3" "354.6" "375.5" "328.6" "333.3" "357.3" "365.9" "353.1" "154.8" "" "" "" "" "" "" "" "" "" "" "317.6" "284.4" "309.4" "280.8" "274.0" "306.1" "301.9" "302.5" "323.9" "154.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7451398436155471702" "False" "High" "IsMasterProtein" "Q9BRZ2" "E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3" "0.000" "False" "5.548" "4" "2" "2" "2" "755" "81.4" "7.74" "3.46" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00643, Pf13445" "81844" "ENSG00000169871" "TRIM56" "hsa:81844; Q6PJS5; Q86VT6; Q8N2H8; Q8NAC0; Q9BRZ2; Q9H031" "Regulation of innate immune responses to cytosolic DNA" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794813676372242912" "False" "High" "IsMasterProtein" "Q96MW5" "Conserved oligomeric Golgi complex subunit 8 OS=Homo sapiens OX=9606 GN=COG8 PE=1 SV=2" "0.000" "False" "5.544" "3" "2" "2" "2" "612" "68.4" "5.20" "6.35" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf04124" "84342" "ENSG00000213380" "COG8" "hsa:84342; Q0VAK2; Q8WVV6; Q96MW5; Q9H6F8" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "0.988" "0.873" "1.254" "1.000" "0.956" "0.893" "0.476" "0.863" "7.506" "200.4" "198.0" "174.9" "251.3" "200.4" "191.5" "179.0" "95.3" "172.9" "1504.0" "" "" "" "" "" "" "" "" "" "" "177.7" "164.0" "152.6" "188.0" "167.1" "175.9" "151.3" "78.8" "158.6" "1504.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "576551174696518957" "False" "High" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "0.000" "False" "5.538" "4" "3" "4" "3" "861" "97.1" "5.64" "8.90" "3" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.120" "1.026" "1.300" "1.093" "1.020" "1.188" "1.194" "1.051" "0.794" "453.9" "508.2" "465.6" "589.8" "496.2" "462.8" "539.3" "541.7" "477.2" "360.6" "" "" "" "" "" "" "" "" "" "" "402.5" "420.9" "406.2" "441.1" "413.7" "425.2" "455.8" "447.8" "437.6" "360.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3991295495987680044" "False" "High" "IsMasterProtein" "Q15544" "Transcription initiation factor TFIID subunit 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1" "0.000" "False" "5.529" "10" "1" "1" "1" "211" "23.3" "4.88" "2.86" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf04719" "6882" "ENSG00000064995" "TAF11" "B2R8R3; B4DY18; hsa:6882; Q15544; Q9UHS0" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6002449157154954042" "False" "High" "IsMasterProtein" "O60346" "PH domain leucine-rich repeat-containing protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PHLPP1 PE=1 SV=3" "0.000" "False" "5.525" "1" "1" "1" "1" "1717" "184.6" "6.28" "3.27" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00169, Pf00481, Pf00560, Pf13516, Pf13855" "23239" "ENSG00000081913" "PHLPP1" "A1A4F5; hsa:23239; O60346; Q641Q7; Q6P4C4; Q6PJI6; Q86TN6; Q96FK2; Q9NUY1" "Negative regulation of the PI3K/AKT network" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "3" "0" "1.141" "0.863" "1.140" "1.259" "1.219" "0.922" "0.862" "0.833" "1.158" "96.6" "110.2" "83.3" "110.1" "121.5" "117.7" "89.0" "83.3" "80.5" "111.8" "" "" "" "" "" "" "" "" "" "" "85.6" "91.2" "72.7" "82.3" "101.3" "108.1" "75.2" "68.8" "73.8" "111.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8298200234612729181" "False" "High" "IsMasterProtein" "P46527" "Cyclin-dependent kinase inhibitor 1B OS=Homo sapiens OX=9606 GN=CDKN1B PE=1 SV=1" "0.000" "False" "5.513" "6" "1" "1" "1" "198" "22.1" "7.02" "5.12" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02234" "1027" "ENSG00000111276" "CDKN1B" "hsa:1027; P46527; Q16307; Q5U0H2; Q9BUS6" "Constitutive Signaling by AKT1 E17K in Cancer; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; SCF(Skp2)-mediated degradation of p27/p21; Senescence-Associated Secretory Phenotype (SASP); DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHO GTPases activate CIT; FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; FLT3 Signaling; PTK6 Regulates Cell Cycle" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Integrated cancer pathway; Thyroid stimulating hormone (TSH) signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Ovarian infertility; Imatinib and chronic myeloid leukemia; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-222 in exercise-induced cardiac growth; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Galanin receptor pathway; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "52" "0" "0.782" "0.666" "0.736" "0.571" "0.445" "0.424" "0.748" "0.825" "0.360" "167.3" "130.8" "111.4" "123.1" "95.6" "74.4" "70.9" "125.1" "138.0" "60.3" "" "" "" "" "" "" "" "" "" "" "148.3" "108.3" "97.2" "92.1" "79.7" "68.4" "59.9" "103.4" "126.5" "60.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8795922102085507366" "False" "High" "IsMasterProtein" "Q9ULM3" "YEATS domain-containing protein 2 OS=Homo sapiens OX=9606 GN=YEATS2 PE=1 SV=2" "0.000" "False" "5.506" "1" "2" "2" "1" "1422" "150.7" "8.98" "5.41" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03366" "55689" "ENSG00000163872" "YEATS2" "A7E2B9; D3DNS9; hsa:55689; Q641P6; Q9NW96; Q9ULM3" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2469591738214607737" "False" "High" "IsMasterProtein" "Q9NRH1" "Protein YAE1 homolog OS=Homo sapiens OX=9606 GN=YAE1 PE=1 SV=1" "0.000" "False" "5.500" "7" "1" "1" "1" "226" "25.3" "5.59" "3.16" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf09811" "57002" "ENSG00000241127" "YAE1" "A4D1W4; B4DE83; hsa:57002; Q6IAF7; Q8WVZ5; Q9NRH1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.000" "False" "5.491" "3" "1" "1" "1" "429" "46.7" "8.62" "4.19" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8406162996631834722" "False" "High" "IsMasterProtein" "Q7L590" "Protein MCM10 homolog OS=Homo sapiens OX=9606 GN=MCM10 PE=1 SV=2" "0.000" "False" "5.485" "1" "1" "1" "1" "875" "98.1" "8.75" "4.46" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09329, Pf09332" "55388" "ENSG00000065328" "MCM10" "A8K9I6; B7ZKZ8; hsa:55388; Q3MIR3; Q7L590; Q7LD55; Q96GX4; Q96NB6; Q9H0D7; Q9H3P9; Q9P177" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex" "Ciliary landscape; DNA replication" "4" "0" "1.140" "1.244" "1.341" "1.096" "1.022" "1.525" "1.586" "1.496" "1.670" "87.2" "99.5" "108.5" "117.0" "95.6" "89.2" "133.0" "138.3" "130.5" "145.6" "" "" "" "" "" "" "" "" "" "" "77.4" "82.4" "94.7" "87.5" "79.7" "81.9" "112.4" "114.4" "119.6" "145.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2052900039050687679" "False" "High" "IsMasterProtein" "Q9Y6X3" "MAU2 chromatid cohesion factor homolog OS=Homo sapiens OX=9606 GN=MAU2 PE=1 SV=2" "0.000" "False" "5.485" "2" "1" "1" "1" "613" "69.0" "7.25" "4.38" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10345" "23383" "ENSG00000129933" "MAU2" "hsa:23383; Q66PT1; Q6P3S7; Q6ZTT2; Q9UFX8; Q9Y6X3" "Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome" "2" "0" "1.283" "1.118" "1.299" "1.094" "1.131" "1.248" "1.015" "0.983" "1.051" "77.6" "99.6" "86.8" "100.9" "84.9" "87.8" "96.9" "78.8" "76.3" "81.6" "" "" "" "" "" "" "" "" "" "" "68.9" "82.5" "75.7" "75.4" "70.8" "80.7" "81.9" "65.1" "70.0" "81.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5805697236743296122" "False" "High" "IsMasterProtein" "Q96QU8" "Exportin-6 OS=Homo sapiens OX=9606 GN=XPO6 PE=1 SV=1" "0.000" "False" "5.481" "1" "1" "1" "1" "1125" "128.8" "6.35" "3.62" "1" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03810, Pf08389" "23214" "ENSG00000169180" "XPO6" "A1L3W4; D3DWF9; hsa:23214; Q2YDX3; Q53G88; Q68G50; Q76N88; Q96CP8; Q96QU8; Q9BT21" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4548642001083058322" "False" "High" "IsMasterProtein" "Q6UXV4" "MICOS complex subunit MIC27 OS=Homo sapiens OX=9606 GN=APOOL PE=1 SV=1" "0.000" "False" "5.480" "6" "1" "1" "1" "268" "29.1" "9.52" "3.60" "1" "cell organization and biogenesis" "non-structural extracellular;other membranes;mitochondrion;other cell component" "" "Pf09769" "139322" "ENSG00000155008" "APOOL" "hsa:139322; Q3KNU7; Q5H9D1; Q6UXV4" "Platelet degranulation ; Cristae formation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3115321329155830276" "False" "High" "IsMasterProtein" "Q9P2D0" "Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3" "0.000" "False" "5.474" "1" "1" "1" "1" "1353" "150.4" "7.71" "3.99" "1" "transport;other biological processes" "other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf00651, Pf12796" "25998" "ENSG00000005700; ENSG00000283068" "IBTK" "hsa:25998; Q2QKU2; Q2QKU3; Q2QKU4; Q5TFD7; Q5TFD9; Q8IUQ9; Q8IUY7; Q8TAI4; Q9HBI8; Q9P2D0; Q9Y3T8" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.940" "0.949" "0.885" "0.815" "0.906" "0.837" "0.902" "0.860" "0.851" "73.9" "69.5" "70.1" "65.4" "60.3" "67.0" "61.9" "66.7" "63.6" "62.9" "" "" "" "" "" "" "" "" "" "" "65.5" "57.5" "61.2" "48.9" "50.3" "61.5" "52.3" "55.1" "58.3" "62.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-255680334974208161" "False" "High" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=3" "0.000" "False" "5.474" "2" "2" "2" "2" "846" "95.0" "7.72" "2.43" "2" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A804HIS2; hsa:11183" "" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "3" "0" "4.183" "0.997" "2.376" "2.833" "3.114" "2.025" "0.849" "2.238" "1.209" "67.7" "283.2" "67.5" "160.9" "191.8" "210.8" "137.1" "57.5" "151.5" "81.9" "" "" "" "" "" "" "" "" "" "" "60.0" "234.6" "58.9" "120.3" "160.0" "193.7" "115.9" "47.5" "139.0" "81.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3496599989848097415" "False" "High" "IsMasterProtein" "Q9ULG6" "Cell cycle progression protein 1 OS=Homo sapiens OX=9606 GN=CCPG1 PE=1 SV=3" "0.000" "False" "5.473" "1" "1" "1" "1" "757" "87.3" "5.95" "4.03" "1" "cell cycle OR cell proliferation;other biological processes" "other membranes" "" "" "9236" "ENSG00000260916" "CCPG1" "A0PJH3; A8K9T0; hsa:9236; O14712; Q05DG4; Q5U5S7; Q8IYV8; Q9BY53; Q9HA17; Q9ULG6" "" "" "0" "0" "0.871" "0.994" "1.005" "0.900" "0.956" "0.847" "0.964" "1.031" "0.395" "80.1" "69.7" "79.5" "80.5" "72.0" "76.5" "67.8" "77.2" "82.5" "31.6" "" "" "" "" "" "" "" "" "" "" "71.0" "57.7" "69.4" "60.2" "60.1" "70.3" "57.3" "63.8" "75.7" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6447964159336659836" "False" "High" "IsMasterProtein" "Q9UL15" "BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1" "0.000" "False" "5.460" "3" "2" "2" "2" "447" "51.2" "6.05" "6.17" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02179" "9529" "ENSG00000166170" "BAG5" "hsa:9529; O94950; Q86W59; Q9UL15" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.996" "0.818" "0.916" "0.853" "0.815" "0.780" "0.520" "0.724" "6.221" "164.7" "164.1" "134.8" "150.9" "140.6" "134.2" "128.5" "85.6" "119.2" "1024.7" "" "" "" "" "" "" "" "" "" "" "146.1" "135.9" "117.6" "112.8" "117.2" "123.3" "108.6" "70.8" "109.3" "1024.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2885282100623052741" "False" "High" "IsMasterProtein" "Q8TAV0" "Protein FAM76A OS=Homo sapiens OX=9606 GN=FAM76A PE=1 SV=1" "0.000" "False" "5.453" "5" "2" "2" "1" "307" "35.0" "9.19" "6.67" "2" "" "nucleus" "" "Pf16046" "199870" "ENSG00000009780" "FAM76A" "B4DWT3; hsa:199870; O95565; O95566; Q8N7J5; Q8TAV0" "" "" "0" "0" "0.923" "0.839" "0.721" "0.708" "0.921" "0.756" "0.727" "0.843" "0.960" "417.9" "385.6" "350.5" "301.3" "295.8" "385.1" "315.9" "303.9" "352.3" "401.1" "" "" "" "" "" "" "" "" "" "" "370.6" "319.4" "305.8" "225.3" "246.7" "353.7" "267.0" "251.2" "323.1" "401.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629743064100226613" "False" "High" "IsMasterProtein" "Q8TAK5" "GA-binding protein subunit beta-2 OS=Homo sapiens OX=9606 GN=GABPB2 PE=1 SV=1" "0.000" "False" "5.446" "3" "1" "1" "1" "448" "48.6" "5.26" "4.37" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796" "126626" "ENSG00000143458" "GABPB2" "B1AVJ8; D3DV14; hsa:126626; Q8NAR5; Q8TAK5" "" "" "0" "0" "1.039" "1.169" "0.924" "0.946" "1.060" "0.927" "0.921" "0.958" "1.617" "58.4" "60.6" "68.2" "53.9" "55.2" "61.9" "54.1" "53.8" "55.9" "94.4" "" "" "" "" "" "" "" "" "" "" "51.7" "50.2" "59.5" "40.3" "46.0" "56.8" "45.7" "44.4" "51.3" "94.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2068779671623766038" "False" "High" "IsMasterProtein" "A6NJ78" "12S rRNA N4-methylcytidine (m4C) methyltransferase OS=Homo sapiens OX=9606 GN=METTL15 PE=1 SV=1" "0.000" "False" "5.433" "3" "1" "1" "1" "407" "46.1" "8.62" "4.15" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf01795" "196074" "ENSG00000169519" "METTL15" "A6NJ78; A8MRS5; B7WNU2; hsa:196074; Q3MHD3; Q8N601; Q8NBA7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2028658389890867927" "False" "High" "IsMasterProtein" "Q99708" "DNA endonuclease RBBP8 OS=Homo sapiens OX=9606 GN=RBBP8 PE=1 SV=2" "0.000" "False" "5.413" "2" "2" "2" "2" "897" "101.9" "6.30" "2.63" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08573, Pf10482" "5932" "ENSG00000101773" "RBBP8" "A6NKN2; A8K8W6; E7ETY1; hsa:5932; O75371; Q8NHQ3; Q99708" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; Transcriptional Regulation by E2F6; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; HDR through MMEJ (alt-NHEJ)" "ATM signaling in development and disease" "18" "0" "0.914" "0.960" "1.009" "0.989" "0.842" "0.818" "1.043" "1.190" "0.528" "219.9" "201.0" "211.1" "221.8" "217.4" "185.1" "179.8" "229.3" "261.7" "116.1" "" "" "" "" "" "" "" "" "" "" "195.0" "166.5" "184.2" "165.9" "181.3" "170.0" "152.0" "189.5" "240.0" "116.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2767038677570436707" "False" "High" "IsMasterProtein" "P82663" "Small ribosomal subunit protein mS25 OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1" "0.000" "False" "5.410" "7" "1" "1" "1" "173" "20.1" "8.82" "3.61" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "64432" "ENSG00000131368" "MRPS25" "B4DFJ5; B4DQG6; hsa:64432; P82663; Q9H7P5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.897" "0.940" "1.068" "0.861" "0.865" "0.982" "0.714" "0.954" "5.982" "103.7" "93.1" "97.5" "110.7" "89.2" "89.7" "101.8" "74.1" "98.9" "620.3" "" "" "" "" "" "" "" "" "" "" "92.0" "77.1" "85.0" "82.8" "74.4" "82.4" "86.1" "61.2" "90.7" "620.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8890451219668255439" "False" "High" "IsMasterProtein" "Q9NZC9" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1" "0.000" "False" "5.404" "2" "1" "2" "1" "954" "105.9" "9.06" "7.61" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07443" "50485" "ENSG00000138375" "SMARCAL1" "A6NEH0; hsa:50485; Q53R00; Q96AY1; Q9NXQ5; Q9NZC9; Q9UFH3; Q9UI93" "" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3273487821867758056" "False" "High" "IsMasterProtein" "Q96DV4" "Large ribosomal subunit protein mL38 OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "0.000" "False" "5.401" "6" "3" "3" "3" "380" "44.6" "7.53" "7.35" "3" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.849" "0.795" "0.700" "0.815" "0.872" "0.863" "0.873" "0.655" "1.148" "112.5" "95.6" "89.4" "78.7" "91.7" "98.1" "97.0" "98.2" "73.7" "129.2" "" "" "" "" "" "" "" "" "" "" "99.8" "79.2" "78.0" "58.9" "76.5" "90.1" "82.0" "81.2" "67.6" "129.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8875331277631851835" "False" "High" "IsMasterProtein" "O75113" "NEDD4-binding protein 1 OS=Homo sapiens OX=9606 GN=N4BP1 PE=1 SV=4" "0.000" "False" "5.384" "2" "1" "1" "1" "896" "100.3" "5.36" "3.64" "1" "stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf11977" "9683" "ENSG00000102921" "N4BP1" "A7MD49; hsa:9683; O75113; Q2YDX1" "Regulation of NF-kappa B signaling" "" "1" "0" "0.624" "0.940" "1.500" "0.473" "0.716" "1.036" "0.331" "0.542" "1.537" "199.2" "124.3" "187.3" "298.8" "94.2" "142.7" "206.4" "66.0" "108.0" "306.2" "" "" "" "" "" "" "" "" "" "" "176.6" "102.9" "163.4" "223.4" "78.5" "131.1" "174.4" "54.5" "99.0" "306.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542485656427922063" "False" "High" "IsMasterProtein" "Q6P1K2" "Polyamine-modulated factor 1 OS=Homo sapiens OX=9606 GN=PMF1 PE=1 SV=2" "0.000" "False" "5.363" "8" "2" "2" "2" "205" "23.3" "5.49" "5.19" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03980" "100527963; 11243" "ENSG00000160783" "PMF1" "A8K0C5; hsa:100527963; hsa:11243; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6P1K2; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172314789071643693" "False" "High" "IsMasterProtein" "Q8IWV7" "E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens OX=9606 GN=UBR1 PE=1 SV=1" "0.000" "False" "5.360" "2" "3" "3" "3" "1749" "200.1" "6.01" "5.05" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "197131" "ENSG00000159459" "UBR1" "O60708; O75492; Q14D45; Q68DN9; Q8IWV7; Q8IWY6; Q96JY4" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.023" "1.130" "1.097" "1.206" "1.240" "1.132" "1.195" "1.170" "0.635" "85.7" "87.6" "96.8" "94.0" "103.3" "106.3" "97.0" "102.4" "100.2" "54.4" "" "" "" "" "" "" "" "" "" "" "76.0" "72.6" "84.5" "70.3" "86.1" "97.6" "82.0" "84.6" "91.9" "54.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904410846819458044" "False" "High" "IsMasterProtein" "Q92796" "Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2" "0.000" "False" "5.360" "2" "2" "2" "2" "817" "90.3" "7.03" "7.60" "2" "cell adhesion;cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600" "1741" "ENSG00000082458" "DLG3" "B4E0H1; D3DVU5; hsa:1741; Q5JUW6; Q5JUW7; Q92796; Q9ULI8" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "Cell lineage map for neuronal differentiation" "11" "0" "0.905" "0.949" "0.821" "0.900" "0.940" "0.935" "0.902" "1.079" "0.781" "551.6" "498.9" "523.3" "453.0" "496.3" "518.3" "515.5" "497.3" "595.0" "430.8" "" "" "" "" "" "" "" "" "" "" "489.1" "413.3" "456.6" "338.8" "413.8" "476.1" "435.7" "411.0" "545.7" "430.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7081455264055243390" "False" "High" "IsMasterProtein" "Q16658" "Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3" "0.000" "False" "5.358" "3" "2" "2" "2" "493" "54.5" "7.24" "5.30" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf06268" "6624" "ENSG00000075618" "FSCN1" "A6NI89; B2RE97; hsa:6624; Q16658; Q96IC5; Q96IH1; Q9BRF1" "Interleukin-4 and Interleukin-13 signaling" "VEGFA-VEGFR2 signaling; Urotensin-II-mediated signaling pathway" "3" "0" "1.075" "0.976" "0.934" "1.055" "1.187" "1.152" "0.909" "1.129" "0.728" "73.5" "79.0" "71.8" "68.7" "77.5" "87.2" "84.7" "66.8" "83.0" "53.5" "" "" "" "" "" "" "" "" "" "" "65.2" "65.4" "62.6" "51.4" "64.6" "80.1" "71.5" "55.2" "76.1" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2663740038882364516" "False" "High" "IsMasterProtein" "Q96S82" "Ubiquitin-like protein 7 OS=Homo sapiens OX=9606 GN=UBL7 PE=1 SV=2" "0.000" "False" "5.358" "8" "2" "2" "2" "380" "40.5" "5.07" "6.55" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00240" "84993" "ENSG00000138629; ENSG00000288408" "UBL7" "D3DW57; hsa:84993; Q96I03; Q96S82" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6098713629868852920" "False" "High" "IsMasterProtein" "Q12772" "Sterol regulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=SREBF2 PE=1 SV=2" "0.000" "False" "5.335" "1" "1" "1" "1" "1141" "123.6" "8.40" "3.49" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6721" "ENSG00000198911" "SREBF2" "hsa:6721; Q05BD5; Q12772; Q6GTH7; Q86V36; Q9UH04" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Transcriptional regulation of white adipocyte differentiation; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Angiopoietin-like protein 8 regulatory pathway; 22q11.2 copy number variation syndrome; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways" "11" "0" "1.041" "0.981" "1.095" "1.181" "0.967" "0.940" "0.955" "1.032" "2.057" "70.6" "73.5" "69.3" "77.4" "83.4" "68.3" "66.4" "67.5" "72.9" "145.3" "" "" "" "" "" "" "" "" "" "" "62.6" "60.9" "60.4" "57.9" "69.5" "62.8" "56.1" "55.8" "66.8" "145.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.000" "False" "5.321" "8" "2" "3" "2" "197" "22.4" "4.70" "9.81" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.036" "1.117" "1.023" "1.064" "0.996" "1.092" "0.925" "1.132" "3.659" "241.2" "249.8" "269.5" "246.7" "256.7" "240.2" "263.5" "223.2" "273.2" "882.5" "" "" "" "" "" "" "" "" "" "" "213.9" "207.0" "235.2" "184.5" "214.0" "220.7" "222.7" "184.5" "250.5" "882.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566707279340017586" "False" "High" "IsMasterProtein" "Q9Y6M7" "Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2" "0.000" "False" "5.297" "2" "2" "2" "2" "1214" "136.0" "6.71" "6.51" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "9497" "ENSG00000033867" "SLC4A7" "A6NIA8; B2CI53; B5M449; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; D3K174; D3K175; hsa:9497; O60350; Q6AHZ9; Q9HC88; Q9UIB9; Q9Y6M7" "RHOQ GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOH GTPase cycle; Bicarbonate transporters" "IL-18 signaling pathway" "7" "0" "0.979" "0.930" "0.895" "0.757" "0.661" "0.606" "0.786" "0.837" "0.670" "282.1" "276.2" "262.4" "252.5" "213.6" "186.6" "170.9" "221.8" "236.1" "189.1" "" "" "" "" "" "" "" "" "" "" "250.2" "228.8" "229.0" "188.8" "178.1" "171.4" "144.4" "183.3" "216.5" "189.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494838164348438910" "False" "High" "IsMasterProtein" "Q08117" "TLE family member 5 OS=Homo sapiens OX=9606 GN=TLE5 PE=1 SV=4" "0.000" "False" "5.294" "12" "2" "2" "2" "197" "22.0" "6.37" "8.88" "2" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03920" "166" "ENSG00000104964" "TLE5" "B2RBL0; hsa:166; Q08117; Q12808; Q14CJ1; Q96TG9; Q9UDY9" "Repression of WNT target genes" "Androgen receptor signaling pathway; Ectoderm differentiation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7040769112947432832" "False" "High" "IsMasterProtein" "Q96EY1" "DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2" "0.000" "False" "5.293" "4" "2" "2" "2" "480" "52.5" "9.26" "6.91" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00226, Pf00684, Pf01556" "9093" "ENSG00000103423; ENSG00000276726" "DNAJA3" "B2RAJ5; B4DI33; E7ES32; hsa:9093; O75472; Q8WUJ6; Q8WXJ3; Q96D76; Q96EY1; Q96IV1; Q9NYH8" "" "" "0" "0" "1.007" "0.820" "1.045" "0.791" "0.641" "0.689" "0.822" "0.926" "2.113" "340.7" "343.0" "279.3" "356.0" "269.7" "218.6" "234.7" "280.0" "315.7" "720.0" "" "" "" "" "" "" "" "" "" "" "302.2" "284.1" "243.7" "266.2" "224.9" "200.8" "198.3" "231.4" "289.5" "720.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330656270512848682" "False" "High" "IsMasterProtein" "Q8WVR3" "Trafficking protein particle complex subunit 14 OS=Homo sapiens OX=9606 GN=TRAPPC14 PE=1 SV=2" "0.000" "False" "5.293" "2" "1" "1" "1" "580" "62.6" "8.87" "4.27" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf15806" "55262" "ENSG00000146826" "TRAPPC14" "A4D2A9; D6W5U4; hsa:55262; Q8WVR3; Q9BQJ1; Q9BUB6; Q9NV47" "" "" "0" "0" "0.982" "1.116" "0.936" "1.037" "0.942" "0.860" "1.058" "0.938" "1.159" "62.0" "60.8" "69.2" "58.0" "64.3" "58.4" "53.3" "65.5" "58.1" "71.8" "" "" "" "" "" "" "" "" "" "" "54.9" "50.4" "60.4" "43.4" "53.6" "53.6" "45.0" "54.2" "53.3" "71.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735333771594595677" "False" "High" "IsMasterProtein" "Q9BYN8" "Small ribosomal subunit protein mS26 OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" "0.000" "False" "5.288" "12" "3" "3" "3" "205" "24.2" "10.39" "5.25" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf14943" "64949" "ENSG00000125901" "MRPS26" "hsa:64949; Q96Q58; Q9BYN8" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.839" "1.001" "0.935" "0.772" "0.853" "0.717" "0.861" "1.041" "2.356" "106.3" "89.2" "106.5" "99.5" "82.1" "90.7" "76.3" "91.6" "110.7" "250.6" "" "" "" "" "" "" "" "" "" "" "94.3" "73.9" "92.9" "74.4" "68.4" "83.3" "64.5" "75.7" "101.6" "250.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.000" "False" "5.275" "1" "1" "1" "1" "1091" "126.2" "6.99" "3.70" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "0.948" "1.067" "1.032" "1.022" "0.977" "1.104" "0.866" "1.097" "5.313" "76.4" "72.5" "81.6" "78.9" "78.1" "74.7" "84.4" "66.2" "83.9" "406.2" "" "" "" "" "" "" "" "" "" "" "67.8" "60.0" "71.2" "59.0" "65.2" "68.6" "71.3" "54.8" "76.9" "406.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7931724043651333300" "False" "High" "IsMasterProtein" "Q9H3S4" "Thiamine pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=TPK1 PE=1 SV=1" "0.000" "False" "5.266" "4" "1" "1" "1" "243" "27.2" "5.20" "3.92" "1" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf04263, Pf04265" "27010" "ENSG00000196511" "TPK1" "A8K0T7; D3DWG0; hsa:27010; I6L9B8; Q6NUR5; Q9H3S4; Q9H602" "Vitamin B1 (thiamin) metabolism" "Thiamine metabolic pathways" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943228809179220327" "False" "High" "IsMasterProtein" "Q8IWX8" "Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3" "0.000" "False" "5.266" "1" "1" "1" "1" "916" "103.6" "9.04" "3.56" "1" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01585, Pf01805, Pf04818" "10523" "ENSG00000085872" "CHERP" "hsa:10523; O00302; Q4G0Y5; Q8IWX8; Q8WU30; Q99492" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1415193059758406037" "False" "High" "IsMasterProtein" "Q9Y689" "ADP-ribosylation factor-like protein 5A OS=Homo sapiens OX=9606 GN=ARL5A PE=1 SV=1" "0.000" "False" "5.260" "7" "1" "2" "1" "179" "20.7" "6.79" "5.63" "1" "transport;other biological processes" "ER/Golgi" "other molecular function" "Pf00025" "26225" "ENSG00000162980" "ARL5A" "hsa:26225; Q580I5; Q9Y689" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-325919897552027140" "False" "High" "IsMasterProtein" "Q9NW08" "DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2" "0.000" "False" "5.255" "2" "2" "2" "2" "1133" "127.7" "8.50" "6.62" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "55703" "ENSG00000013503" "POLR3B" "A8K6H0; B3KV73; F5H1E6; hsa:55703; Q9NW08; Q9NW59" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7363542337896916296" "False" "High" "IsMasterProtein" "Q8NHP6" "Motile sperm domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MOSPD2 PE=1 SV=1" "0.000" "False" "5.251" "3" "2" "2" "2" "518" "59.7" "5.96" "6.36" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00635, Pf00650" "158747" "ENSG00000130150" "MOSPD2" "hsa:158747; Q8N3H2; Q8NA83; Q8NHP6" "Neutrophil degranulation; RHOD GTPase cycle" "" "2" "0" "1.046" "0.948" "0.962" "1.091" "0.864" "1.100" "1.004" "1.062" "1.462" "154.8" "162.0" "146.9" "148.9" "169.0" "133.7" "170.4" "155.5" "164.5" "226.3" "" "" "" "" "" "" "" "" "" "" "137.3" "134.2" "128.1" "111.4" "140.9" "122.8" "144.0" "128.5" "150.9" "226.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8452919191869770403" "False" "High" "IsMasterProtein" "Q8WVV9" "Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1" "0.000" "False" "5.244" "4" "2" "2" "1" "542" "60.0" "7.72" "6.73" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "92906" "ENSG00000143889" "HNRNPLL" "hsa:92906; Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q8WVV9; Q96HR5" "" "" "0" "0" "0.958" "0.741" "0.806" "0.671" "0.802" "0.693" "0.166" "0.713" "9.157" "85.0" "81.4" "63.0" "68.5" "57.0" "68.2" "58.9" "14.1" "60.6" "778.3" "" "" "" "" "" "" "" "" "" "" "75.4" "67.4" "55.0" "51.3" "47.5" "62.6" "49.8" "11.7" "55.5" "778.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7234885358333908901" "False" "High" "IsMasterProtein" "O75915" "PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1" "0.000" "False" "5.244" "10" "2" "2" "2" "188" "21.6" "9.77" "6.01" "2" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "" "Pf03208" "10550" "ENSG00000144746" "ARL6IP5" "B2R6V5; hsa:10550; O75915; Q53ES3; Q5KU08" "Glutamate Neurotransmitter Release Cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6257492621702889989" "False" "High" "IsMasterProtein" "Q10589" "Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=1 SV=1" "0.000" "False" "5.243" "6" "1" "1" "1" "180" "19.8" "5.60" "4.32" "1" "stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf16716" "684" "ENSG00000130303" "BST2" "A8K4Y4; hsa:684; Q10589; Q53G07" "Neutrophil degranulation; Interferon alpha/beta signaling; SARS-CoV-1 activates/modulates innate immune responses" "Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling" "5" "0" "0.986" "0.960" "1.090" "1.102" "0.995" "1.044" "1.048" "1.263" "0.871" "170.0" "167.6" "163.2" "185.3" "187.3" "169.2" "177.5" "178.1" "214.7" "148.2" "" "" "" "" "" "" "" "" "" "" "150.8" "138.8" "142.4" "138.5" "156.2" "155.5" "150.0" "147.2" "196.9" "148.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2412952300113516382" "False" "High" "IsMasterProtein" "Cont_P28800" "Alpha-2-antiplasmin OS=Bos taurus OX=9913 GN=SERPINF2 PE=1 SV=2" "0.000" "True" "5.238" "2" "1" "1" "1" "492" "54.7" "5.72" "3.31" "1" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00079" "282522" "ENSBIXG00000029361; ENSBTAG00000020859" "SERPINF2" "A0A4W2DRH6; bta:282522; P28800" "Platelet degranulation ; Dissolution of Fibrin Clot" "Complement and coagulation cascades; Blood clotting cascade" "4" "0" "1.186" "1.098" "0.978" "1.177" "0.906" "1.164" "1.152" "0.972" "0.527" "167.3" "198.3" "183.7" "163.6" "196.9" "151.6" "194.8" "192.7" "162.6" "88.2" "" "" "" "" "" "" "" "" "" "" "148.3" "164.3" "160.3" "122.4" "164.1" "139.2" "164.6" "159.3" "149.1" "88.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486015732534254879" "False" "High" "IsMasterProtein" "Q7Z5W3" "RNA 5'-monophosphate methyltransferase OS=Homo sapiens OX=9606 GN=BCDIN3D PE=1 SV=1" "0.000" "False" "5.226" "3" "1" "1" "1" "292" "33.2" "6.70" "4.07" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "144233" "ENSG00000186666" "BCDIN3D" "A8K829; hsa:144233; Q7Z5W3" "MicroRNA (miRNA) biogenesis" "" "1" "0" "0.911" "0.963" "0.815" "0.870" "0.827" "0.911" "0.916" "0.901" "0.500" "115.3" "105.0" "111.0" "93.9" "100.3" "95.4" "105.0" "105.5" "103.9" "57.7" "" "" "" "" "" "" "" "" "" "" "102.2" "87.0" "96.9" "70.2" "83.6" "87.6" "88.8" "87.2" "95.3" "57.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1924362681764607279" "False" "High" "IsMasterProtein" "Q8TBF4" "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=ZCRB1 PE=1 SV=2" "0.000" "False" "5.212" "14" "2" "2" "2" "217" "24.6" "8.53" "2.56" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00098" "85437" "ENSG00000139168" "ZCRB1" "hsa:85437; Q6PJX0; Q8TBF4; Q96TA6" "mRNA Splicing - Minor Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "" "3" "0" "1.082" "1.086" "1.139" "1.070" "1.027" "1.286" "1.206" "1.051" "0.761" "65.7" "71.1" "71.3" "74.8" "70.3" "67.5" "84.4" "79.2" "69.0" "50.0" "" "" "" "" "" "" "" "" "" "" "58.2" "58.9" "62.2" "55.9" "58.6" "62.0" "71.4" "65.4" "63.3" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139955916062878316" "False" "High" "IsMasterProtein" "Q9BZ95" "Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1" "0.000" "False" "5.210" "1" "1" "1" "1" "1437" "161.5" "8.21" "4.57" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf00856, Pf17907, Pf17982" "54904" "ENSG00000147548" "NSD3" "B7ZL11; D3DSX1; hsa:54904; Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9BZ95; Q9H2M8; Q9H9W9; Q9NXA6" "PKMTs methylate histone lysines" "" "1" "0" "0.902" "0.942" "0.930" "0.812" "0.810" "0.751" "0.714" "0.771" "1.849" "144.6" "130.3" "136.1" "134.5" "117.4" "117.1" "108.5" "103.3" "111.5" "267.2" "" "" "" "" "" "" "" "" "" "" "128.2" "108.0" "118.8" "100.6" "97.9" "107.6" "91.7" "85.4" "102.3" "267.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945924760519134314" "False" "High" "IsMasterProtein" "Q9H9C1" "Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1" "0.000" "False" "5.208" "3" "1" "1" "1" "493" "57.0" "7.40" "4.42" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04840" "63894" "ENSG00000151445" "VIPAS39" "B4DPI6; hsa:63894; O95434; Q9H7E1; Q9H9C1; Q9H9I9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5673730343044781282" "False" "High" "IsMasterProtein" "Q96HS1" "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" "0.000" "False" "5.205" "3" "1" "1" "1" "289" "32.0" "8.68" "3.34" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;other molecular function" "Pf00300" "192111" "ENSG00000247077" "PGAM5" "A9LN06; C9IZY7; hsa:192111; Q96HS1; Q96JB0" "" "NRF2-ARE regulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2405290564278907927" "False" "High" "IsMasterProtein" "O14775" "Guanine nucleotide-binding protein subunit beta-5 OS=Homo sapiens OX=9606 GN=GNB5 PE=1 SV=2" "0.000" "False" "5.204" "4" "2" "2" "2" "395" "43.5" "6.46" "5.32" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "10681" "ENSG00000069966" "GNB5" "B2RBR5; O14775; Q9HAU9; Q9UFT3" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits" "Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "High" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.000" "False" "5.202" "14" "2" "2" "2" "145" "16.3" "8.60" "5.97" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "" "3" "0" "0.990" "0.888" "1.049" "0.828" "0.736" "1.055" "0.828" "0.914" "0.493" "58.2" "57.6" "51.7" "61.1" "48.2" "42.9" "61.4" "48.2" "53.2" "28.7" "" "" "" "" "" "" "" "" "" "" "51.6" "47.7" "45.1" "45.7" "40.2" "39.4" "51.9" "39.9" "48.8" "28.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933841314574218963" "False" "High" "IsMasterProtein" "Q99633" "Pre-mRNA-splicing factor 18 OS=Homo sapiens OX=9606 GN=PRPF18 PE=1 SV=1" "0.000" "False" "5.197" "6" "2" "2" "2" "342" "39.8" "8.15" "6.90" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02840, Pf08799" "8559" "ENSG00000165630" "PRPF18" "hsa:8559; Q5T9P9; Q99633; Q9BUI9" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.038" "0.999" "1.091" "1.022" "1.037" "0.971" "0.940" "0.998" "2.340" "331.2" "343.7" "330.9" "361.5" "338.4" "343.4" "321.7" "311.3" "330.5" "775.0" "" "" "" "" "" "" "" "" "" "" "293.7" "284.7" "288.7" "270.4" "282.2" "315.5" "271.9" "257.3" "303.1" "775.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "538564902379484332" "False" "High" "IsMasterProtein" "P49815" "Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2" "0.000" "False" "5.177" "1" "2" "2" "2" "1807" "200.5" "7.31" "5.06" "2" "stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf03542, Pf11864" "7249" "ENSG00000103197" "TSC2" "A7E2E2; B4DIL8; B4DIQ7; B4DRN2; B7Z2B8; C9J378; hsa:7249; O75275; P49815; Q4LE71; Q8TAZ1" "Macroautophagy; Constitutive Signaling by AKT1 E17K in Cancer; TP53 Regulates Metabolic Genes; AKT phosphorylates targets in the cytosol; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; ATM signaling in development and disease ; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; p53 transcriptional gene network; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Monoamine transport" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7828527280741994957" "False" "High" "IsMasterProtein" "O75971" "snRNA-activating protein complex subunit 5 OS=Homo sapiens OX=9606 GN=SNAPC5 PE=1 SV=1" "0.000" "False" "5.176" "17" "1" "1" "1" "98" "11.3" "4.58" "3.31" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15497" "10302" "ENSG00000174446" "SNAPC5" "A8K7N6; hsa:10302; O75971; Q96CF3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "7606738261010209794" "False" "High" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "0.000" "False" "5.169" "5" "2" "3" "2" "592" "67.3" "5.92" "7.19" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "Ras signaling" "6" "0" "1.073" "1.000" "0.933" "0.931" "1.078" "0.912" "0.911" "1.065" "3.957" "125.2" "134.3" "125.2" "116.7" "116.5" "135.0" "114.1" "114.0" "133.4" "495.3" "" "" "" "" "" "" "" "" "" "" "111.0" "111.3" "109.3" "87.3" "97.2" "124.0" "96.5" "94.2" "122.3" "495.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-72385411951020745" "False" "High" "IsMasterProtein" "Q5VUM1" "Succinate dehydrogenase assembly factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF4 PE=1 SV=1" "0.000" "False" "5.160" "9" "1" "1" "1" "108" "12.2" "9.36" "4.10" "1" "cell organization and biogenesis;other metabolic processes;stress response" "mitochondrion" "enzyme regulator activity" "Pf07896" "135154" "ENSG00000154079" "SDHAF4" "E1P532; hsa:135154; Q5VUM1" "" "Mitochondrial complex II assembly" "1" "0" "0.969" "1.024" "1.068" "0.916" "1.037" "1.063" "1.040" "0.959" "0.513" "134.7" "130.6" "137.9" "143.9" "123.3" "139.7" "143.2" "140.1" "129.2" "69.1" "" "" "" "" "" "" "" "" "" "" "119.4" "108.1" "120.3" "107.6" "102.8" "128.4" "121.0" "115.8" "118.5" "69.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-32317680153119671" "False" "High" "IsMasterProtein" "O95620" "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like OS=Homo sapiens OX=9606 GN=DUS4L PE=1 SV=2" "0.000" "False" "5.159" "6" "2" "2" "2" "317" "35.8" "7.33" "5.52" "2" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "11062" "ENSG00000105865; ENSG00000284103" "DUS4L" "B4DLX0; hsa:11062; O95620; Q2NKK1" "" "" "0" "0" "0.981" "0.977" "1.100" "0.964" "1.000" "1.048" "0.976" "1.096" "0.812" "132.5" "130.0" "129.6" "145.8" "127.8" "132.5" "138.9" "129.4" "145.3" "107.6" "" "" "" "" "" "" "" "" "" "" "117.5" "107.7" "113.0" "109.1" "106.6" "121.7" "117.4" "106.9" "133.2" "107.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173769377935829106" "False" "High" "IsMasterProtein" "Cont_P15497" "Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3" "0.000" "True" "5.143" "9" "3" "4" "2" "265" "30.3" "5.97" "11.87" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "281631" "ENSBIXG00000010441; ENSBIXG00005004093; ENSBTAG00000002258" "APOA1" "A0A4W2DWW2; A5D7M9; bta:281631; P15497; Q3SZD9; V6F9A2" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors" "Statin pathway; Folate metabolism; Vitamin B12 metabolism; Selenium micronutrient network" "15" "0" "0.948" "0.802" "1.031" "0.977" "1.212" "1.027" "0.872" "0.932" "0.541" "135.3" "128.4" "108.6" "139.6" "132.3" "164.0" "139.1" "118.1" "126.1" "73.2" "" "" "" "" "" "" "" "" "" "" "120.0" "106.3" "94.7" "104.4" "110.3" "150.6" "117.5" "97.6" "115.7" "73.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6022231960649743773" "False" "High" "IsMasterProtein" "P21695" "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Homo sapiens OX=9606 GN=GPD1 PE=1 SV=4" "0.000" "False" "5.141" "6" "3" "3" "2" "349" "37.5" "6.18" "9.10" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "2819" "ENSG00000167588" "GPD1" "F8W1L5; hsa:2819; P21695; Q8N1B0" "Synthesis of PA" "HIF1A and PPARG regulation of glycolysis; Triacylglyceride synthesis" "3" "0" "0.908" "0.824" "0.994" "0.856" "0.745" "0.913" "0.982" "0.896" "0.572" "260.5" "236.6" "214.6" "258.9" "223.0" "194.1" "237.9" "255.9" "233.4" "148.9" "" "" "" "" "" "" "" "" "" "" "231.0" "196.0" "187.2" "193.6" "186.0" "178.3" "201.1" "211.5" "214.1" "148.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3944939482947776682" "False" "High" "IsMasterProtein" "P00480" "Ornithine transcarbamylase, mitochondrial OS=Homo sapiens OX=9606 GN=OTC PE=1 SV=3" "0.000" "False" "5.130" "2" "1" "6" "1" "354" "39.9" "8.63" "13.92" "1" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00185, Pf02729" "5009" "ENSG00000036473" "OTC" "A8K9P2; D3DWB0; hsa:5009; P00480; Q3KNR1; Q6B0I1; Q9NYJ5" "Mitochondrial protein import; Urea cycle" "Amino acid metabolism" "3" "0" "0.844" "0.802" "0.982" "0.690" "1.024" "0.895" "0.905" "0.615" "0.380" "666.9" "563.1" "535.0" "654.6" "459.9" "683.0" "596.8" "603.7" "410.2" "253.6" "" "" "" "" "" "" "" "" "" "" "591.4" "466.4" "466.8" "489.6" "383.5" "627.4" "504.4" "499.0" "376.2" "253.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4225597047578388345" "False" "High" "IsMasterProtein" "Q9H334" "Forkhead box protein P1 OS=Homo sapiens OX=9606 GN=FOXP1 PE=1 SV=1" "0.000" "False" "5.122" "3" "2" "2" "2" "677" "75.3" "6.67" "5.61" "2" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16159" "27086" "ENSG00000114861" "FOXP1" "A3QVP8; B3KV70; G5E9V8; hsa:27086; Q8NAN6; Q9BSG9; Q9H332; Q9H333; Q9H334; Q9P0R1" "" "" "0" "0" "1.083" "0.880" "0.980" "1.035" "0.879" "1.030" "0.905" "0.988" "3.107" "174.9" "189.5" "153.8" "171.4" "181.0" "153.8" "180.1" "158.2" "172.8" "543.3" "" "" "" "" "" "" "" "" "" "" "155.1" "156.9" "134.2" "128.2" "151.0" "141.2" "152.2" "130.7" "158.5" "543.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7954061042394864873" "False" "High" "IsMasterProtein" "Q8WYB5" "Histone acetyltransferase KAT6B OS=Homo sapiens OX=9606 GN=KAT6B PE=1 SV=3" "0.000" "False" "5.104" "1" "2" "2" "2" "2073" "231.2" "5.96" "3.97" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf01853, Pf17772, Pf21524" "23522" "ENSG00000156650; ENSG00000281813" "KAT6B" "hsa:23522; O15087; Q86Y05; Q8WU81; Q8WYB5; Q9UKW2; Q9UKW3; Q9UKX0" "HATs acetylate histones" "" "1" "0" "1.124" "1.010" "1.011" "1.071" "1.092" "1.009" "0.958" "1.131" "0.885" "162.8" "183.1" "164.5" "164.6" "174.5" "177.8" "164.3" "156.0" "184.2" "144.2" "" "" "" "" "" "" "" "" "" "" "144.4" "151.7" "143.5" "123.1" "145.5" "163.3" "138.9" "129.0" "168.9" "144.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4312046131050647574" "False" "High" "IsMasterProtein" "Q9NPR2" "Semaphorin-4B OS=Homo sapiens OX=9606 GN=SEMA4B PE=1 SV=4" "0.000" "False" "5.099" "3" "2" "2" "2" "837" "92.7" "7.05" "4.25" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf01403, Pf01437" "10509" "ENSG00000185033" "SEMA4B" "hsa:10509; J3KNP4; Q6UXE3; Q8WVP9; Q96FK5; Q9C0B8; Q9H691; Q9NPM8; Q9NPN0; Q9NPR2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141620358562250456" "False" "High" "IsMasterProtein" "Q8NCB2" "CaM kinase-like vesicle-associated protein OS=Homo sapiens OX=9606 GN=CAMKV PE=1 SV=2" "0.000" "False" "5.092" "3" "1" "1" "1" "501" "54.3" "5.55" "2.74" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069" "79012" "ENSG00000164076" "CAMKV" "A6NFD4; hsa:79012; Q6FIB8; Q8NBS8; Q8NC85; Q8NCB2; Q8NDU4; Q8WTT8; Q9BQC9; Q9H0Q5" "" "" "0" "0" "0.928" "0.965" "1.175" "0.900" "1.217" "0.772" "0.520" "0.967" "0.970" "19.7" "18.2" "19.0" "23.1" "17.7" "23.9" "15.2" "10.2" "19.0" "19.1" "" "" "" "" "" "" "" "" "" "" "17.4" "15.1" "16.5" "17.3" "14.7" "22.0" "12.8" "8.5" "17.4" "19.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "812774364720566677" "False" "High" "IsMasterProtein" "P53794" "Sodium/myo-inositol cotransporter OS=Homo sapiens OX=9606 GN=SLC5A3 PE=1 SV=4" "0.000" "False" "5.088" "2" "1" "1" "1" "718" "79.6" "7.47" "3.82" "1" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00474" "6526" "ENSG00000198743" "SLC5A3" "O43489; P53794" "Inositol transporters" "Nuclear receptors meta-pathway; NRF2 pathway" "3" "0" "1.034" "0.895" "1.144" "1.177" "0.824" "1.049" "0.858" "0.942" "0.637" "79.9" "82.6" "71.5" "91.4" "94.1" "65.9" "83.8" "68.5" "75.2" "50.9" "" "" "" "" "" "" "" "" "" "" "70.9" "68.4" "62.4" "68.4" "78.4" "60.5" "70.8" "56.7" "69.0" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1046080233580331926" "False" "High" "IsMasterProtein" "Q8TEK3" "Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens OX=9606 GN=DOT1L PE=1 SV=3" "0.000" "False" "5.084" "1" "1" "1" "1" "1537" "164.8" "9.19" "3.13" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08123" "84444" "ENSG00000104885" "DOT1L" "hsa:84444; O60379; Q8TEK3; Q96JL1" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "0.760" "0.843" "0.831" "0.806" "0.654" "0.870" "0.694" "0.846" "0.889" "28.4" "21.5" "23.9" "23.6" "22.8" "18.6" "24.7" "19.7" "24.0" "25.2" "" "" "" "" "" "" "" "" "" "" "25.1" "17.8" "20.8" "17.6" "19.0" "17.0" "20.8" "16.3" "22.0" "25.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6161986969394420318" "False" "High" "IsMasterProtein" "O95081" "Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=AGFG2 PE=1 SV=2" "0.000" "False" "5.084" "2" "1" "1" "1" "481" "48.9" "9.11" "3.50" "1" "" "other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "3268" "ENSG00000106351" "AGFG2" "hsa:3268; O75429; O95081; Q96AB9; Q96GL4" "" "" "0" "0" "0.832" "0.659" "0.744" "0.720" "0.572" "0.511" "0.543" "0.642" "3.945" "55.2" "45.9" "36.4" "41.1" "39.7" "31.6" "28.2" "30.0" "35.4" "217.7" "" "" "" "" "" "" "" "" "" "" "48.9" "38.0" "31.7" "30.7" "33.1" "29.0" "23.9" "24.8" "32.5" "217.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7026483087037268354" "False" "High" "IsMasterProtein" "Q05823" "2-5A-dependent ribonuclease OS=Homo sapiens OX=9606 GN=RNASEL PE=1 SV=2" "0.000" "False" "5.083" "2" "1" "2" "1" "741" "83.5" "6.65" "5.48" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00023, Pf00069, Pf06479" "6041" "ENSG00000135828" "RNASEL" "hsa:6041; Q05823; Q5W0L2; Q6AI46" "OAS antiviral response; Interferon alpha/beta signaling" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.000" "False" "5.068" "3" "1" "1" "1" "356" "38.5" "7.39" "4.49" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "Processing of SMDT1; Cellular response to mitochondrial stress" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7880299812085229449" "False" "High" "IsMasterProtein" "P11049" "Leukocyte antigen CD37 OS=Homo sapiens OX=9606 GN=CD37 PE=1 SV=2" "0.000" "False" "5.065" "3" "1" "1" "1" "281" "31.7" "7.94" "4.10" "1" "" "plasma membrane" "" "Pf00335" "951" "ENSG00000104894" "CD37" "B4DVC1; hsa:951; P11049; Q3KPF9" "" "TYROBP causal network in microglia" "1" "0" "1.061" "0.927" "0.987" "1.049" "1.110" "1.039" "0.920" "1.391" "0.806" "339.2" "359.9" "314.6" "334.8" "355.9" "376.4" "352.3" "312.0" "471.9" "273.3" "" "" "" "" "" "" "" "" "" "" "300.8" "298.1" "274.5" "250.4" "296.7" "345.8" "297.8" "257.9" "432.8" "273.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2436656635601103317" "False" "High" "IsMasterProtein" "Q3ZCW2" "Galectin-related protein OS=Homo sapiens OX=9606 GN=LGALSL PE=1 SV=2" "0.000" "False" "5.054" "6" "1" "1" "1" "172" "19.0" "5.35" "4.09" "1" "" "" "other molecular function" "Pf00337" "29094" "ENSG00000119862" "LGALSL" "B2RBG8; D6W5E8; hsa:29094; Q3ZCW2; Q6P5T6; Q9P005" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5414866276259702487" "False" "High" "IsMasterProtein" "Cont_P81644" "Apolipoprotein A-II OS=Bos taurus OX=9913 GN=APOA2 PE=1 SV=2" "0.000" "True" "5.047" "9" "1" "1" "1" "100" "11.2" "8.10" "3.12" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf04711" "109578286; 505394" "ENSBIXG00000027093; ENSBIXG00005019464; ENSBTAG00000009212" "APOA2" "A0A4W2I5U3; A0A6P5E192; biu:109578286; bta:505394; P81644; Q2NKV9" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; Retinoid metabolism and transport" "Statin pathway" "6" "0" "1.006" "0.958" "0.693" "0.957" "0.848" "1.026" "0.737" "0.833" "0.873" "236.6" "238.0" "226.5" "163.9" "226.3" "200.7" "242.8" "174.3" "197.1" "206.6" "" "" "" "" "" "" "" "" "" "" "209.8" "197.2" "197.6" "122.6" "188.7" "184.3" "205.2" "144.1" "180.7" "206.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8271257472643545210" "False" "High" "IsMasterProtein" "Q6PCE3" "Glucose 1,6-bisphosphate synthase OS=Homo sapiens OX=9606 GN=PGM2L1 PE=1 SV=3" "0.000" "False" "5.043" "3" "2" "4" "1" "622" "70.4" "7.15" "6.58" "2" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf02878, Pf02879, Pf02880" "283209" "ENSG00000165434" "PGM2L1" "hsa:283209; Q6PCE3; Q96MQ7; Q9UIK3" "Glycolysis" "" "1" "0" "0.994" "0.640" "0.814" "0.890" "0.633" "0.716" "0.621" "0.873" "0.328" "24.7" "24.5" "15.8" "20.1" "22.0" "15.6" "17.7" "15.3" "21.5" "8.1" "" "" "" "" "" "" "" "" "" "" "21.9" "20.3" "13.8" "15.0" "18.3" "14.3" "14.9" "12.7" "19.7" "8.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6104701307196402264" "False" "High" "IsMasterProtein" "Q96PE3" "Inositol polyphosphate-4-phosphatase type I A OS=Homo sapiens OX=9606 GN=INPP4A PE=1 SV=1" "0.000" "False" "5.041" "2" "2" "3" "2" "977" "109.9" "6.96" "8.05" "2" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "" "3631" "ENSG00000040933" "INPP4A" "hsa:3631; O15326; Q13187; Q53TD8; Q8TC02; Q96PE3" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "Insulin signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952210186294942098" "False" "High" "IsMasterProtein" "O15315" "DNA repair protein RAD51 homolog 2 OS=Homo sapiens OX=9606 GN=RAD51B PE=1 SV=2" "0.001" "False" "5.016" "3" "1" "1" "1" "384" "42.2" "5.69" "3.82" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5890" "ENSG00000182185" "RAD51B" "hsa:5890; O15315; O60914; O75210; Q3Y4F8; Q6FHX8; Q86SY3; Q86SY4; Q86TR0; Q86U92; Q86U93; Q86U94; Q8N6H4; Q9UPL5" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "High" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.001" "False" "5.010" "1" "1" "1" "1" "1030" "113.2" "6.35" "4.10" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "Cytosolic iron-sulfur cluster assembly" "2q11.2 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119048535094086908" "False" "High" "IsMasterProtein" "P82912" "Small ribosomal subunit protein uS11m OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "0.001" "False" "5.000" "6" "1" "1" "1" "194" "20.6" "10.81" "4.07" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6222796260561926749" "False" "High" "IsMasterProtein" "Q9NXW2" "DnaJ homolog subfamily B member 12 OS=Homo sapiens OX=9606 GN=DNAJB12 PE=1 SV=5" "0.001" "False" "4.982" "5" "2" "2" "1" "375" "41.8" "8.69" "7.15" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00226, Pf09320" "54788" "ENSG00000148719" "DNAJB12" "B7Z7I3; hsa:54788; Q9H6H0; Q9NXW2" "" "" "0" "0" "1.096" "1.043" "0.890" "0.938" "1.100" "0.970" "1.053" "1.089" "0.994" "105.8" "116.0" "110.3" "94.2" "99.2" "116.3" "102.6" "111.5" "115.3" "105.2" "" "" "" "" "" "" "" "" "" "" "93.8" "96.1" "96.3" "70.4" "82.8" "106.9" "86.7" "92.1" "105.7" "105.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1043542800326556912" "False" "High" "IsMasterProtein" "Q9NRA0" "Sphingosine kinase 2 OS=Homo sapiens OX=9606 GN=SPHK2 PE=1 SV=2" "0.001" "False" "4.981" "2" "1" "1" "1" "654" "69.2" "6.95" "3.72" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00781, Pf19279" "56848" "ENSG00000063176" "SPHK2" "A0T4C8; B4DU87; hsa:56848; Q9BRN1; Q9H0Q2; Q9NRA0; Q9NWU7" "Sphingolipid de novo biosynthesis" "Sphingolipid pathway; S1P receptor signal transduction; Metabolism of sphingolipids in ER and Golgi apparatus; Sphingolipid metabolism: integrated pathway; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids" "7" "0" "1.019" "0.998" "0.938" "1.181" "1.101" "1.333" "1.128" "1.000" "1.400" "59.9" "61.1" "59.8" "56.2" "70.7" "66.0" "79.9" "67.6" "59.9" "83.9" "" "" "" "" "" "" "" "" "" "" "53.1" "50.6" "52.2" "42.0" "59.0" "60.6" "67.5" "55.9" "54.9" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3091495107374211726" "False" "High" "IsMasterProtein" "Q9H501" "ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1" "0.001" "False" "4.977" "2" "2" "2" "2" "851" "98.7" "5.11" "6.30" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08159" "51575" "ENSG00000089048" "ESF1" "hsa:51575; Q86X92; Q9H501; Q9H9Q5; Q9HA35; Q9NX93; Q9P1S6" "" "" "0" "0" "0.999" "0.991" "0.972" "0.987" "1.009" "0.924" "0.830" "0.916" "2.267" "481.3" "480.8" "477.1" "467.6" "475.2" "485.4" "444.5" "399.4" "441.1" "1090.9" "" "" "" "" "" "" "" "" "" "" "426.8" "398.3" "416.3" "349.7" "396.2" "445.9" "375.7" "330.1" "404.5" "1090.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6083245125138804483" "False" "High" "IsMasterProtein" "Q15027" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1" "0.001" "False" "4.968" "3" "2" "2" "1" "740" "81.5" "7.66" "6.04" "2" "transport" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00023, Pf00169, Pf01412, Pf16746" "9744" "ENSG00000072818; ENSG00000288169" "ACAP1" "hsa:9744; Q15027; Q53XN9" "" "Nucleotide-binding oligomerization domain (NOD) pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3008882847524475916" "False" "High" "IsMasterProtein" "Q15041" "ADP-ribosylation factor-like protein 6-interacting protein 1 OS=Homo sapiens OX=9606 GN=ARL6IP1 PE=1 SV=2" "0.001" "False" "4.965" "7" "2" "5" "1" "203" "23.3" "9.32" "13.48" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "" "23204" "ENSG00000170540" "ARL6IP1" "B7Z6S5; B7Z791; F5GXP4; hsa:23204; Q15041" "" "" "0" "0" "1.083" "0.944" "1.104" "1.026" "0.968" "0.954" "0.925" "0.894" "0.802" "379.5" "411.0" "358.1" "418.8" "389.3" "367.4" "362.2" "350.9" "339.3" "304.5" "" "" "" "" "" "" "" "" "" "" "336.5" "340.5" "312.4" "313.2" "324.6" "337.5" "306.1" "290.1" "311.2" "304.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3357604607996684691" "False" "High" "IsMasterProtein" "Q9NX58" "Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=3" "0.001" "False" "4.944" "4" "1" "1" "1" "379" "43.6" "9.57" "4.18" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08790, Pf17848" "55646" "ENSG00000145220" "LYAR" "D3DVS4; hsa:55646; Q6FI78; Q9NX58; Q9NYS1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "504093738677667823" "False" "High" "IsMasterProtein" "O14867" "Transcription regulator protein BACH1 OS=Homo sapiens OX=9606 GN=BACH1 PE=1 SV=2" "0.001" "False" "4.934" "4" "2" "2" "2" "736" "81.9" "5.05" "6.55" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "571" "ENSG00000156273" "BACH1" "hsa:571; O14867; O43285; Q6ICU0" "Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes" "Integrated cancer pathway; Ferroptosis" "6" "0" "0.992" "0.883" "0.888" "0.882" "0.841" "0.935" "0.945" "0.939" "0.963" "110.2" "109.3" "97.3" "97.8" "97.2" "92.6" "103.1" "104.2" "103.4" "106.1" "" "" "" "" "" "" "" "" "" "" "97.7" "90.6" "84.9" "73.2" "81.1" "85.1" "87.1" "86.1" "94.9" "106.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8605151959694531472" "False" "High" "IsMasterProtein" "Q13888" "General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1" "0.001" "False" "4.933" "2" "1" "1" "1" "395" "44.4" "6.76" "4.12" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus" "other molecular function" "Pf04056, Pf07975" "2966" "ENSG00000145736; ENSG00000275045; ENSG00000276910" "GTF2H2" "hsa:2966; Q13888; Q15570; Q15571; Q9BS41" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4527402495997135849" "False" "High" "IsMasterProtein" "Q08AG7" "Mitotic-spindle organizing protein 1 OS=Homo sapiens OX=9606 GN=MZT1 PE=1 SV=2" "0.001" "False" "4.932" "20" "1" "1" "1" "82" "8.5" "4.78" "3.57" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf12554" "440145" "ENSG00000204899" "MZT1" "hsa:440145; Q08AG7; Q5W0P5" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366050407919946154" "False" "High" "IsMasterProtein" "Q96II8" "DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2" "0.001" "False" "4.930" "2" "1" "1" "1" "777" "86.0" "6.71" "3.68" "1" "cell organization and biogenesis" "cytosol;other cell component" "" "Pf00307, Pf13855" "84859" "ENSG00000186001" "LRCH3" "B4E0T7; hsa:84859; Q96FP9; Q96II8; Q9NT52" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2097918301010195378" "False" "High" "IsMasterProtein" "P28715" "DNA excision repair protein ERCC-5 OS=Homo sapiens OX=9606 GN=ERCC5 PE=1 SV=3" "0.001" "False" "4.926" "2" "2" "2" "2" "1186" "133.0" "5.22" "4.47" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2073" "ENSG00000134899" "ERCC5" "A6NGT4; hsa:2073; P28715; Q5JUS4; Q5JUS5; Q7Z2V3; Q8IZL6; Q8N1B7; Q9HD59; Q9HD60" "Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; 10q11.21q11.23 copy number variation syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344595424207440426" "False" "High" "IsMasterProtein" "Q96RT8" "Gamma-tubulin complex component 5 OS=Homo sapiens OX=9606 GN=TUBGCP5 PE=1 SV=1" "0.001" "False" "4.919" "2" "1" "2" "1" "1024" "118.2" "5.90" "5.61" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf04130, Pf17681" "114791" "ENSG00000275835" "TUBGCP5" "E9PB12; hsa:114791; Q6IQ52; Q96PY8; Q96RT8" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7529344055509267771" "False" "High" "IsMasterProtein" "Q96T83" "Sodium/hydrogen exchanger 7 OS=Homo sapiens OX=9606 GN=SLC9A7 PE=1 SV=1" "0.001" "False" "4.916" "1" "1" "1" "1" "725" "80.1" "6.42" "3.20" "1" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf00999" "84679" "ENSG00000065923" "SLC9A7" "hsa:84679; O75827; Q5JXP9; Q96T83" "Sodium/Proton exchangers" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3069559242831628546" "False" "High" "IsMasterProtein" "Q7Z460" "CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1" "0.001" "False" "4.915" "2" "2" "2" "2" "1538" "169.3" "9.03" "3.51" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21040" "23332" "ENSG00000074054" "CLASP1" "A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Role of ABL in ROBO-SLIT signaling" "Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9052184028571704461" "False" "High" "IsMasterProtein" "O75865" "Trafficking protein particle complex subunit 6A OS=Homo sapiens OX=9606 GN=TRAPPC6A PE=1 SV=2" "0.001" "False" "4.915" "9" "2" "2" "2" "159" "17.6" "5.26" "5.74" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf04051" "79090" "ENSG00000007255" "TRAPPC6A" "hsa:79090; K7ERB1; K7ERQ4; O75865; Q9BQ45; Q9P092" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "0.923" "0.865" "0.952" "0.865" "0.866" "1.017" "0.862" "0.806" "1.827" "186.7" "172.3" "161.6" "177.8" "161.4" "161.6" "189.9" "160.9" "150.4" "341.2" "" "" "" "" "" "" "" "" "" "" "165.6" "142.7" "141.0" "133.0" "134.6" "148.5" "160.5" "133.0" "137.9" "341.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4311553193835580120" "False" "High" "IsMasterProtein" "P56556" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFA6 PE=1 SV=4" "0.001" "False" "4.913" "13" "2" "2" "2" "128" "15.1" "9.98" "3.35" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity" "Pf13233" "4700" "ENSG00000184983; ENSG00000272765; ENSG00000273397; ENSG00000277365; ENSG00000281013" "NDUFA6" "B2RE54; hsa:4700; O43675; P56556; Q6FGW0; Q6IBT8; Q6IC39" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9007576609156077388" "False" "High" "IsMasterProtein" "Q9UN70" "Protocadherin gamma-C3 OS=Homo sapiens OX=9606 GN=PCDHGC3 PE=1 SV=1" "0.001" "False" "4.912" "2" "2" "2" "2" "934" "101.0" "5.21" "6.07" "2" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974, Pf16492" "5098" "ENSG00000240184" "PCDHGC3" "hsa:5098; O60622; Q08192; Q9UN70; Q9Y5C4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5567026577194719019" "False" "High" "IsMasterProtein" "Q9Y2Z9" "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Homo sapiens OX=9606 GN=COQ6 PE=1 SV=2" "0.001" "False" "4.911" "2" "1" "1" "1" "468" "50.8" "7.30" "3.53" "1" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf01494" "51004" "ENSG00000119723" "COQ6" "B7Z3K8; hsa:51004; Q53GG6; Q86U30; Q96CA1; Q96CK2; Q9Y2Z9" "Ubiquinol biosynthesis" "Nephrotic syndrome" "2" "0" "1.029" "0.967" "1.111" "0.907" "0.957" "1.041" "0.991" "1.024" "0.795" "70.7" "72.7" "68.4" "78.6" "64.1" "67.7" "73.6" "70.1" "72.4" "56.2" "" "" "" "" "" "" "" "" "" "" "62.7" "60.2" "59.6" "58.8" "53.5" "62.1" "62.2" "57.9" "66.4" "56.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-750359377190588192" "False" "High" "IsMasterProtein" "O75616" "GTPase Era, mitochondrial OS=Homo sapiens OX=9606 GN=ERAL1 PE=1 SV=2" "0.001" "False" "4.906" "3" "1" "1" "1" "437" "48.3" "8.84" "3.73" "1" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "translation activity;nucleic acid binding activity;other molecular function" "Pf01926" "26284" "ENSG00000132591" "ERAL1" "B3KN21; C9JEC6; hsa:26284; O75616; O75617; Q8WUY4; Q96LE2; Q96TC0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Primary ovarian insufficiency" "4" "0" "0.946" "1.146" "0.941" "0.810" "1.094" "1.017" "0.010" "0.762" "23.512" "11.7" "11.1" "13.4" "11.0" "9.5" "12.8" "11.9" "0.0" "8.9" "274.9" "" "" "" "" "" "" "" "" "" "" "10.4" "9.2" "11.7" "8.2" "7.9" "11.7" "10.0" "0.0" "8.2" "274.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "-3071806788293272628" "False" "High" "IsMasterProtein" "Q5EG05" "Caspase recruitment domain-containing protein 16 OS=Homo sapiens OX=9606 GN=CARD16 PE=1 SV=1" "0.001" "False" "4.906" "5" "1" "1" "1" "197" "22.6" "8.44" "4.33" "1" "protein metabolism;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00619" "114769" "ENSG00000204397" "CARD16" "hsa:114769; Q5EG05; Q96RJ9" "" "" "0" "0" "1.040" "0.959" "1.088" "1.003" "1.033" "1.032" "1.055" "0.989" "1.529" "144.8" "150.6" "138.9" "157.5" "145.3" "149.6" "149.4" "152.7" "143.2" "221.3" "" "" "" "" "" "" "" "" "" "" "128.4" "124.7" "121.2" "117.8" "121.2" "137.5" "126.2" "126.2" "131.4" "221.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3254824567455471781" "False" "High" "IsMasterProtein" "Q6NSI4" "RPA-related protein RADX OS=Homo sapiens OX=9606 GN=RADX PE=1 SV=2" "0.001" "False" "4.899" "1" "1" "1" "1" "855" "97.5" "8.41" "3.92" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf17659" "55086" "ENSG00000147231" "RADX" "H7BY89; hsa:55086; Q4G0L7; Q5JQS1; Q5JRF9; Q6NSI4; Q6PHY5; Q6PII9; Q6PJU8; Q9H7W5; Q9NWA6" "" "" "0" "0" "0.902" "1.575" "1.099" "1.125" "1.203" "2.728" "2.454" "3.302" "11.282" "15.1" "13.6" "23.8" "16.6" "17.0" "18.2" "41.2" "37.1" "49.9" "170.6" "" "" "" "" "" "" "" "" "" "" "13.4" "11.3" "20.8" "12.4" "14.2" "16.7" "34.9" "30.7" "45.8" "170.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293840026169595064" "False" "High" "IsMasterProtein" "Q6ZVK8" "8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens OX=9606 GN=NUDT18 PE=1 SV=3" "0.001" "False" "4.894" "3" "1" "1" "1" "323" "35.5" "6.23" "3.51" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00293" "79873" "ENSG00000275074" "NUDT18" "hsa:79873; Q6ZVK8; Q8IZ75; Q9H687" "" "" "0" "0" "1.163" "1.149" "1.192" "1.065" "1.102" "0.990" "1.059" "1.153" "0.629" "134.2" "156.1" "154.2" "160.0" "142.9" "147.9" "132.9" "142.1" "154.8" "84.4" "" "" "" "" "" "" "" "" "" "" "119.0" "129.3" "134.5" "119.7" "119.2" "135.8" "112.3" "117.4" "141.9" "84.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1292677114640833852" "False" "High" "IsMasterProtein" "Q5VZL5" "Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1" "0.001" "False" "4.889" "1" "1" "1" "1" "1548" "172.7" "6.84" "4.74" "1" "cell organization and biogenesis;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9202" "ENSG00000146463" "ZMYM4" "A0JP19; A0JP20; hsa:9202; O43308; Q5T5E1; Q5T5E2; Q5VZL5; Q7L3Q4" "" "" "0" "0" "0.938" "0.793" "0.914" "1.120" "0.961" "0.946" "0.860" "1.003" "1.236" "100.1" "93.8" "79.4" "91.4" "112.1" "96.2" "94.7" "86.0" "100.3" "123.6" "" "" "" "" "" "" "" "" "" "" "88.7" "77.7" "69.3" "68.4" "93.5" "88.4" "80.0" "71.1" "92.0" "123.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910924152517685584" "False" "High" "IsMasterProtein" "P13612" "Integrin alpha-4 OS=Homo sapiens OX=9606 GN=ITGA4 PE=1 SV=3" "0.001" "False" "4.888" "2" "2" "2" "2" "1032" "114.8" "6.48" "7.11" "2" "cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01839, Pf08441, Pf20805, Pf20806" "3676" "ENSG00000115232" "ITGA4" "D3DPG4; hsa:3676; P13612; Q7Z4L6" "Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Potential therapeutics for SARS; Integrin cell surface interactions; RUNX3 Regulates Immune Response and Cell Migration" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Cells and molecules involved in local acute inflammatory response ; Pleural mesothelioma; 11p11.2 copy number variation syndrome" "14" "0" "0.976" "0.882" "1.012" "0.909" "0.963" "0.947" "0.932" "0.891" "0.477" "517.4" "504.8" "456.1" "523.4" "470.4" "498.1" "490.0" "482.0" "461.1" "246.6" "" "" "" "" "" "" "" "" "" "" "458.8" "418.2" "398.0" "391.4" "392.2" "457.6" "414.2" "398.4" "422.9" "246.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7420075580370482485" "False" "High" "IsMasterProtein" "P14209" "CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1" "0.001" "False" "4.881" "5" "1" "1" "1" "185" "18.8" "4.75" "4.31" "1" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf12301" "4267" "ENSG00000002586; ENSG00000292348" "CD99" "A6NIW1; hsa:4267; O00518; P14209; Q6ICV7" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8775799832689222428" "False" "High" "IsMasterProtein" "Q8IV38" "Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1" "0.001" "False" "4.856" "3" "2" "2" "2" "441" "49.3" "6.25" "4.13" "2" "" "other cell component" "other molecular function" "Pf01753, Pf12796" "57037" "ENSG00000106524" "ANKMY2" "A4D124; hsa:57037; Q659G1; Q8IV38; Q96BL3" "" "" "0" "0" "0.798" "0.830" "0.818" "0.796" "0.899" "1.098" "0.917" "0.944" "1.372" "26.5" "21.2" "22.0" "21.7" "21.1" "23.9" "29.1" "24.3" "25.0" "36.4" "" "" "" "" "" "" "" "" "" "" "23.5" "17.5" "19.2" "16.2" "17.6" "21.9" "24.6" "20.1" "23.0" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506397020611828412" "False" "High" "IsMasterProtein" "B7ZLF3" "C2H2-type domain-containing protein OS=Homo sapiens OX=9606 GN=LOC402624 PE=1 SV=1" "0.001" "False" "4.852" "7" "1" "1" "1" "203" "22.4" "9.03" "5.71" "1" "other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf00096" "" "ENSG00000284691" "LOC402624" "B7ZLF3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5240696879354608925" "False" "High" "IsMasterProtein" "Q8IUF1" "Zinc-regulated GTPase metalloprotein activator 1B OS=Homo sapiens OX=9606 GN=ZNG1B PE=1 SV=1" "0.001" "False" "4.850" "4" "1" "1" "1" "395" "44.0" "4.89" "2.27" "1" "" "nucleus;other cell component" "other molecular function" "Pf02492, Pf07683" "150472" "ENSG00000136682" "ZNG1B" "hsa:150472; Q0VAN3; Q8IUF1" "" "" "0" "0" "1.049" "1.029" "0.971" "1.154" "1.247" "1.032" "1.141" "0.951" "0.962" "177.6" "186.4" "182.7" "172.4" "205.0" "221.5" "183.3" "202.7" "168.9" "170.8" "" "" "" "" "" "" "" "" "" "" "157.5" "154.4" "159.4" "128.9" "170.9" "203.5" "154.9" "167.6" "154.9" "170.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3937524236337839102" "False" "High" "IsMasterProtein" "P32121" "Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2" "0.001" "False" "4.842" "4" "1" "1" "1" "409" "46.1" "7.69" "2.59" "1" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00339, Pf02752" "409" "ENSG00000141480" "ARRB2" "B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6" "Ub-specific processing proteases; Thrombin signalling through proteinase activated receptors (PARs); Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; Activation of SMO; G alpha (s) signalling events; Signaling by BRAF and RAF1 fusions; WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "27" "0" "2.288" "1.294" "1.750" "1.589" "1.586" "2.009" "1.567" "1.346" "1.295" "45.4" "103.9" "58.8" "79.5" "72.1" "72.0" "91.2" "71.2" "61.1" "58.8" "" "" "" "" "" "" "" "" "" "" "40.3" "86.1" "51.3" "59.4" "60.2" "66.2" "77.1" "58.8" "56.1" "58.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361421774522293685" "False" "High" "IsMasterProtein" "P98155" "Very low-density lipoprotein receptor OS=Homo sapiens OX=9606 GN=VLDLR PE=1 SV=1" "0.001" "False" "4.842" "2" "2" "2" "1" "873" "96.0" "4.79" "3.83" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00057, Pf00058, Pf07645, Pf14670" "7436" "ENSG00000147852" "VLDLR" "B2RMZ7; D3DRH6; hsa:7436; P98155; Q5VVF6" "VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance" "Familial hyperlipidemia type 3; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6970631393786121187" "False" "High" "IsMasterProtein" "Q8WU79" "Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1" "0.001" "False" "4.832" "3" "2" "2" "2" "429" "46.8" "8.87" "5.28" "2" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "64744" "ENSG00000084070" "SMAP2" "B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; hsa:64744; Q5QPL2; Q8WU79; Q96C93; Q9NST2; Q9UJL8" "" "" "0" "0" "1.079" "1.042" "1.203" "1.020" "0.902" "0.986" "0.823" "1.062" "4.117" "64.8" "69.9" "67.5" "78.0" "66.1" "58.5" "63.9" "53.4" "68.8" "266.9" "" "" "" "" "" "" "" "" "" "" "57.5" "57.9" "58.9" "58.3" "55.1" "53.7" "54.0" "44.1" "63.1" "266.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7711638653191853085" "False" "High" "IsMasterProtein" "Q9UMR5" "Lysosomal thioesterase PPT2 OS=Homo sapiens OX=9606 GN=PPT2 PE=1 SV=4" "0.001" "False" "4.831" "5" "1" "1" "1" "302" "34.2" "6.33" "5.18" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf02089" "9374" "ENSG00000168452; ENSG00000206256; ENSG00000206329; ENSG00000221988; ENSG00000227600; ENSG00000228116; ENSG00000231618; ENSG00000236649" "PPT2" "A2ABC9; A2ABD1; A2ARM7; A2BFH7; A2BFH9; A2BFI2; A8K9L4; B0S868; G8JLE1; hsa:9374; O14799; Q0P6K0; Q5JP13; Q5JP14; Q5JQF0; Q5SSX4; Q5SSX5; Q5SSX6; Q5STJ4; Q5STJ5; Q5STJ6; Q6FI80; Q99945; Q9UMR5" "Fatty acyl-CoA biosynthesis" "IL-18 signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3436560803263431899" "False" "High" "IsMasterProtein" "P14921" "Protein C-ets-1 OS=Homo sapiens OX=9606 GN=ETS1 PE=1 SV=1" "0.001" "False" "4.825" "2" "1" "1" "1" "441" "50.4" "5.19" "3.19" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf19525" "2113" "ENSG00000134954" "ETS1" "A9UL17; F5GYX9; hsa:2113; P14921; Q14278; Q16080; Q6N087; Q96AC5" "Oncogene Induced Senescence" "Neural crest differentiation; B cell receptor signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Melanoma; Extrafollicular and follicular B cell activation by SARS-CoV-2" "11" "0" "1.086" "0.913" "1.066" "0.942" "1.050" "0.799" "0.313" "0.862" "8.129" "102.3" "111.1" "93.4" "109.1" "96.4" "107.4" "81.7" "32.0" "88.1" "831.6" "" "" "" "" "" "" "" "" "" "" "90.7" "92.0" "81.5" "81.6" "80.4" "98.6" "69.1" "26.5" "80.8" "831.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.001" "False" "4.810" "2" "2" "2" "1" "761" "84.3" "6.80" "4.85" "2" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "RHOJ GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "CAMKK2 pathway; Regulation of actin cytoskeleton" "12" "0" "3.360" "0.876" "1.050" "2.941" "2.392" "1.407" "0.691" "0.847" "3.973" "121.4" "408.0" "106.4" "127.5" "357.1" "290.4" "170.8" "83.9" "102.9" "482.5" "" "" "" "" "" "" "" "" "" "" "107.7" "338.0" "92.8" "95.4" "297.8" "266.8" "144.4" "69.4" "94.4" "482.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-31044771765994045" "False" "High" "IsMasterProtein" "Cont_Q6E0U4" "Dermokine OS=Homo sapiens OX=9606 GN=DMKN PE=1 SV=3" "0.001" "True" "4.807" "2" "1" "1" "1" "476" "47.1" "7.28" "3.44" "1" "cell organization and biogenesis" "non-structural extracellular" "" "" "93099" "ENSG00000161249" "DMKN" "A3EZ79; A3EZ80; A3EZ81; A3EZ82; A3EZ83; C9J4P6; C9J5N8; C9JAL3; hsa:93099; Q32W58; Q32W62; Q32W63; Q32W64; Q32W65; Q32W66; Q32W67; Q6E0U4; Q6E0U5; Q6UXC7; Q96EW8; Q9BSY6" "" "" "0" "0" "0.494" "0.387" "0.480" "7.757" "0.651" "0.295" "0.503" "0.687" "0.531" "165.0" "81.5" "63.8" "79.1" "1279.7" "107.4" "48.7" "83.0" "113.3" "87.7" "" "" "" "" "" "" "" "" "" "" "146.3" "67.5" "55.7" "59.2" "1067.1" "98.6" "41.2" "68.6" "103.9" "87.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728373557133263535" "False" "High" "IsMasterProtein" "Q12797" "Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH PE=1 SV=3" "0.001" "False" "4.801" "3" "1" "1" "1" "758" "85.8" "5.01" "2.73" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf05118, Pf05279, Pf13174" "444" "ENSG00000198363" "ASPH" "A0A0A0MSK8; A6NDF4; A6NHI2; B4DIC9; B4E2K4; B7ZM95; E5RGP5; F5H667; hsa:444; Q12797; Q6NXR7; Q8TB28; Q9H291; Q9H2C4; Q9NRI0; Q9NRI1; Q9Y4J0" "Stimuli-sensing channels; Protein hydroxylation; Ion homeostasis" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "Not Found" "1" "" "-9040602984972190355" "False" "High" "IsMasterProtein" "Q9Y259" "Choline/ethanolamine kinase OS=Homo sapiens OX=9606 GN=CHKB PE=1 SV=3" "0.001" "False" "4.794" "3" "1" "2" "1" "395" "45.2" "5.49" "8.78" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1120" "ENSG00000100288" "CHKB" "A0PJM6; hsa:1120; Q13388; Q9Y259" "Synthesis of PC; Synthesis of PE" "Fatty acid beta-oxidation; Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "7" "0" "1.045" "0.967" "1.100" "1.096" "1.136" "0.999" "0.937" "0.881" "0.575" "207.5" "216.9" "200.7" "228.3" "227.5" "235.7" "207.3" "194.3" "182.7" "119.3" "" "" "" "" "" "" "" "" "" "" "184.0" "179.7" "175.1" "170.8" "189.7" "216.5" "175.2" "160.6" "167.6" "119.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4022376780209334762" "False" "High" "IsMasterProtein" "Q96EM0" "Trans-3-hydroxy-L-proline dehydratase OS=Homo sapiens OX=9606 GN=L3HYPDH PE=1 SV=2" "0.001" "False" "4.792" "8" "2" "2" "2" "354" "38.1" "6.68" "2.72" "2" "" "" "other molecular function" "Pf05544" "112849" "ENSG00000126790" "L3HYPDH" "hsa:112849; Q96EM0; Q96LJ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619952528215347024" "False" "High" "IsMasterProtein" "P09326" "CD48 antigen OS=Homo sapiens OX=9606 GN=CD48 PE=1 SV=2" "0.001" "False" "4.787" "6" "2" "2" "2" "243" "27.7" "8.07" "6.10" "2" "stress response" "plasma membrane;other membranes" "" "Pf07686, Pf13895" "962" "ENSG00000117091" "CD48" "hsa:962; P09326; Q5U055; Q8MGR0" "Cell surface interactions at the vascular wall" "Gastric cancer network 2" "2" "0" "0.895" "0.860" "0.868" "0.991" "1.039" "0.920" "0.990" "0.923" "0.412" "200.2" "179.2" "172.1" "173.8" "198.3" "208.0" "184.2" "198.1" "184.7" "82.4" "" "" "" "" "" "" "" "" "" "" "177.5" "148.5" "150.1" "130.0" "165.4" "191.0" "155.7" "163.7" "169.4" "82.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3568941862227660384" "False" "High" "IsMasterProtein" "Q9NVP2" "Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1" "0.001" "False" "4.787" "15" "2" "3" "1" "202" "22.4" "4.56" "5.79" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04729" "55723" "ENSG00000105011; ENSG00000288210" "ASF1B" "hsa:55723; Q53G51; Q9NVP2; Q9NVZ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2465041974174611566" "False" "High" "IsMasterProtein" "Q96BT7" "Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens OX=9606 GN=ALKBH8 PE=1 SV=2" "0.001" "False" "4.775" "1" "1" "2" "1" "664" "75.2" "7.99" "5.17" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08241, Pf09004, Pf13532" "91801" "ENSG00000137760" "ALKBH8" "B1Q2M0; B4DEF6; hsa:91801; Q8N989; Q96BT7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.883" "0.821" "0.822" "0.811" "0.765" "0.785" "0.617" "0.730" "4.979" "163.0" "143.9" "133.8" "134.0" "132.2" "124.6" "128.0" "100.6" "119.0" "811.4" "" "" "" "" "" "" "" "" "" "" "144.5" "119.2" "116.8" "100.2" "110.3" "114.4" "108.1" "83.2" "109.1" "811.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8309198551146026693" "False" "High" "IsMasterProtein" "O15226" "NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2" "0.001" "False" "4.773" "2" "1" "1" "1" "690" "77.6" "8.79" "4.27" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01424, Pf01585" "55922" "ENSG00000186416" "NKRF" "G3V1N1; O15226; Q4VC41; Q9UJ91" "" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3442007542301277656" "False" "High" "IsMasterProtein" "Q8N5U6" "E3 ubiquitin-protein ligase RNF10 OS=Homo sapiens OX=9606 GN=RNF10 PE=1 SV=2" "0.001" "False" "4.773" "1" "1" "1" "1" "811" "89.9" "6.92" "4.30" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13445" "9921" "ENSG00000022840" "RNF10" "hsa:9921; Q8N5U6; Q92550; Q9NPP8; Q9ULW4" "" "" "0" "0" "0.908" "0.960" "0.914" "1.002" "0.864" "0.873" "0.842" "0.941" "2.703" "26.2" "23.8" "25.1" "23.9" "26.2" "22.6" "22.8" "22.0" "24.6" "70.7" "" "" "" "" "" "" "" "" "" "" "23.2" "19.7" "21.9" "17.9" "21.9" "20.8" "19.3" "18.2" "22.6" "70.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2563545888999241244" "False" "High" "IsMasterProtein" "Q9P2D3" "HEAT repeat-containing protein 5B OS=Homo sapiens OX=9606 GN=HEATR5B PE=1 SV=2" "0.001" "False" "4.746" "1" "2" "2" "2" "2071" "224.2" "7.17" "4.43" "2" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf20210" "54497" "ENSG00000008869" "HEATR5B" "B5MDU8; hsa:54497; Q7Z3B2; Q9NVL7; Q9P2D3" "" "" "0" "0" "0.873" "0.803" "1.325" "0.870" "0.498" "1.076" "0.732" "0.761" "0.885" "64.4" "56.2" "51.7" "85.3" "56.0" "32.1" "69.3" "47.1" "49.0" "57.0" "" "" "" "" "" "" "" "" "" "" "57.1" "46.6" "45.1" "63.8" "46.7" "29.5" "58.5" "38.9" "44.9" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2996634066211424368" "False" "High" "IsMasterProtein" "Q92994" "Transcription factor IIIB 90 kDa subunit OS=Homo sapiens OX=9606 GN=BRF1 PE=1 SV=1" "0.001" "False" "4.745" "2" "1" "1" "1" "677" "73.8" "5.43" "4.14" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf07741, Pf08271" "2972" "ENSG00000185024" "BRF1" "B3KU36; B4DIG5; B7Z2N3; F5H5Z7; F8WA46; hsa:2972; Q13223; Q3SYD9; Q5PR24; Q6IQ02; Q92994; Q96KX3; Q9HCW6; Q9HCW7; Q9HCW8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "TAR syndrome" "4" "0" "1.148" "0.858" "0.782" "0.903" "1.210" "0.835" "0.590" "0.709" "2.642" "24.5" "28.2" "21.0" "19.2" "22.1" "29.7" "20.5" "14.5" "17.4" "64.8" "" "" "" "" "" "" "" "" "" "" "21.8" "23.3" "18.4" "14.3" "18.5" "27.3" "17.3" "12.0" "16.0" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5045228690157758775" "False" "High" "IsMasterProtein" "Q9Y4E6" "WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2" "0.001" "False" "4.740" "1" "2" "2" "2" "1490" "163.7" "6.92" "3.09" "2" "other biological processes" "other cell component" "" "Pf00400" "23335" "ENSG00000091157" "WDR7" "A7E2C8; hsa:23335; Q86UX5; Q86VP2; Q96PS7; Q9Y4E6" "" "" "0" "0" "0.824" "0.993" "0.873" "1.291" "0.889" "0.842" "0.976" "1.333" "2.499" "37.4" "30.9" "37.2" "32.7" "48.3" "33.3" "31.5" "36.5" "49.9" "93.5" "" "" "" "" "" "" "" "" "" "" "33.2" "25.6" "32.4" "24.4" "40.3" "30.6" "26.6" "30.2" "45.7" "93.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3186791909088934819" "False" "High" "IsMasterProtein" "Q96JB2" "Conserved oligomeric Golgi complex subunit 3 OS=Homo sapiens OX=9606 GN=COG3 PE=1 SV=3" "0.001" "False" "4.735" "1" "1" "1" "1" "828" "94.0" "5.57" "4.80" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "" "Pf04136, Pf20671" "83548" "ENSG00000136152" "COG3" "B2RAW5; hsa:83548; Q5VT70; Q8IXX4; Q96JB2; Q9BZ92" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072914358106661187" "False" "High" "IsMasterProtein" "P86397" "Hydroxyacyl-thioester dehydratase type 2, mitochondrial OS=Homo sapiens OX=9606 GN=HTD2 PE=1 SV=1" "0.001" "False" "4.734" "10" "2" "2" "2" "168" "18.5" "8.92" "2.18" "2" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01575" "109703458" "ENSG00000255154" "HTD2" "P86397" "Fatty acyl-CoA biosynthesis" "Mitochondrial fatty acid synthesis pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8885735133454120700" "False" "High" "IsMasterProtein" "Q13277" "Syntaxin-3 OS=Homo sapiens OX=9606 GN=STX3 PE=1 SV=3" "0.001" "False" "4.733" "5" "2" "2" "2" "289" "33.1" "5.44" "6.12" "2" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00804, Pf05739" "6809" "ENSG00000166900" "STX3" "B4DME0; hsa:6809; O43750; O43751; Q13277; Q15360" "Other interleukin signaling" "Synaptic vesicle pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6232139059952850141" "False" "High" "IsMasterProtein" "O94874" "E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2" "0.001" "False" "4.727" "1" "1" "3" "1" "794" "89.5" "6.79" "8.17" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09743" "23376" "ENSG00000014123" "UFL1" "A0PJ53; B4DJ57; C0H5X5; hsa:23376; O94874; Q8N765; Q9NTQ0" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.481" "1.452" "1.347" "1.384" "1.410" "1.700" "1.069" "1.314" "8.685" "54.0" "80.0" "78.5" "72.8" "74.8" "76.2" "91.9" "57.8" "71.0" "469.3" "" "" "" "" "" "" "" "" "" "" "47.9" "66.3" "68.5" "54.4" "62.4" "70.0" "77.7" "47.7" "65.1" "469.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7674938862773320945" "False" "High" "IsMasterProtein" "A3KMH1" "von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2" "0.001" "False" "4.723" "1" "2" "2" "2" "1905" "214.7" "7.40" "5.76" "2" "" "mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07728" "23078" "ENSG00000102763" "VWA8" "A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6282194941215119925" "False" "High" "IsMasterProtein" "Q9HAW0" "Transcription factor IIIB 50 kDa subunit OS=Homo sapiens OX=9606 GN=BRF2 PE=1 SV=1" "0.001" "False" "4.719" "2" "1" "1" "1" "419" "46.5" "7.94" "3.15" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08271" "55290" "ENSG00000104221" "BRF2" "B2RD62; B4DFZ6; D3DSW6; hsa:55290; Q9H2Y3; Q9H3B3; Q9HAW0; Q9NUY6" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "" "2" "0" "1.122" "1.017" "1.266" "0.759" "1.133" "1.009" "0.010" "0.680" "18.904" "11.0" "12.3" "11.1" "13.9" "8.3" "12.4" "11.0" "0.0" "7.4" "207.1" "" "" "" "" "" "" "" "" "" "" "9.7" "10.2" "9.7" "10.4" "6.9" "11.4" "9.3" "0.0" "6.8" "207.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "5661386699023188299" "False" "High" "IsMasterProtein" "Q9Y4B4" "Helicase ARIP4 OS=Homo sapiens OX=9606 GN=RAD54L2 PE=1 SV=4" "0.001" "False" "4.716" "1" "1" "1" "1" "1467" "162.7" "6.09" "3.57" "1" "cell organization and biogenesis" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "23132" "ENSG00000164080" "RAD54L2" "hsa:23132; Q8TB57; Q9BV54; Q9Y4B4" "" "DYRK1A involvement regarding cell proliferation in brain development" "1" "0" "0.973" "0.961" "1.106" "0.915" "0.781" "0.804" "0.648" "0.968" "5.872" "116.5" "113.3" "112.0" "128.9" "106.6" "91.0" "93.7" "75.5" "112.7" "683.9" "" "" "" "" "" "" "" "" "" "" "103.3" "93.9" "97.7" "96.4" "88.9" "83.6" "79.2" "62.4" "103.4" "683.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271823877594573979" "False" "High" "IsMasterProtein" "P27105" "Stomatin OS=Homo sapiens OX=9606 GN=STOM PE=1 SV=3" "0.001" "False" "4.715" "3" "1" "1" "1" "288" "31.7" "7.88" "2.26" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01145" "2040" "ENSG00000148175" "STOM" "B1AM77; hsa:2040; P27105; Q14087; Q15609; Q5VX96; Q96FK4" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; Stimuli-sensing channels; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOH GTPase cycle" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Ciliary landscape" "12" "0" "1.291" "0.769" "1.124" "0.953" "0.982" "0.926" "0.794" "1.625" "0.676" "63.9" "82.5" "49.1" "71.9" "60.9" "62.7" "59.2" "50.7" "103.9" "43.2" "" "" "" "" "" "" "" "" "" "" "56.7" "68.4" "42.9" "53.7" "50.8" "57.6" "50.0" "41.9" "95.3" "43.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8769161245985835007" "False" "High" "IsMasterProtein" "Q9NYF3" "Protein FAM53C OS=Homo sapiens OX=9606 GN=FAM53C PE=1 SV=1" "0.001" "False" "4.715" "5" "2" "2" "2" "392" "43.1" "8.65" "6.86" "2" "transport" "nucleus" "" "Pf15242" "51307" "ENSG00000120709" "FAM53C" "B2RDJ5; D3DQB9; hsa:51307; Q9NYF3" "" "" "0" "0" "1.328" "1.054" "1.079" "1.062" "1.011" "1.176" "1.116" "1.192" "1.023" "125.9" "167.3" "132.8" "135.9" "133.8" "127.3" "148.2" "140.6" "150.1" "128.8" "" "" "" "" "" "" "" "" "" "" "111.7" "138.6" "115.8" "101.7" "111.6" "117.0" "125.2" "116.2" "137.7" "128.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7259467159663286133" "False" "High" "IsMasterProtein" "Q9Y5N6" "Origin recognition complex subunit 6 OS=Homo sapiens OX=9606 GN=ORC6 PE=1 SV=1" "0.001" "False" "4.706" "5" "1" "1" "1" "252" "28.1" "8.66" "3.40" "1" "DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05460" "23594" "ENSG00000091651" "ORC6" "B3KN89; hsa:23594; Q9Y5N6" "Orc1 removal from chromatin; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849479475208291816" "False" "High" "IsMasterProtein" "Q9H8Y5" "tRNA endonuclease ANKZF1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1" "0.001" "False" "4.704" "2" "1" "1" "1" "726" "80.9" "8.41" "3.74" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf00023, Pf18716, Pf18826" "55139" "ENSG00000163516" "ANKZF1" "hsa:55139; Q9H8Y5; Q9NVZ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658162067205247997" "False" "High" "IsMasterProtein" "Q969E2" "Secretory carrier-associated membrane protein 4 OS=Homo sapiens OX=9606 GN=SCAMP4 PE=1 SV=1" "0.001" "False" "4.698" "5" "1" "1" "1" "229" "25.7" "8.82" "3.10" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf04144" "113178" "ENSG00000227500" "SCAMP4" "hsa:113178; Q8N2N1; Q8NAV0; Q969E2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2087285006199939008" "False" "High" "IsMasterProtein" "P61626" "Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1" "0.001" "False" "4.696" "6" "1" "1" "1" "148" "16.5" "9.16" "3.42" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00062" "4069" "ENSG00000090382" "LYZ" "hsa:4069; P00695; P61626; Q13170; Q9UCF8" "Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides" "Macrophage markers; Pancreatic cancer subtypes" "5" "0" "1.144" "1.212" "1.718" "2.252" "2.151" "1.070" "0.742" "3.366" "1.938" "67.2" "76.9" "81.5" "115.5" "151.4" "144.6" "72.0" "49.9" "226.2" "130.3" "" "" "" "" "" "" "" "" "" "" "59.6" "63.7" "71.1" "86.4" "126.2" "132.9" "60.8" "41.2" "207.5" "130.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7474037307863270970" "False" "High" "IsMasterProtein" "Q96TC7" "Regulator of microtubule dynamics protein 3 OS=Homo sapiens OX=9606 GN=RMDN3 PE=1 SV=2" "0.001" "False" "4.688" "2" "1" "1" "1" "470" "52.1" "5.10" "4.00" "1" "other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity" "Pf21033" "55177" "ENSG00000137824" "RMDN3" "A9UMZ9; B3KRR3; hsa:55177; Q6ZWE9; Q96H23; Q96SD6; Q96TC7; Q9H6G1; Q9NVQ6" "" "" "0" "0" "1.025" "0.964" "1.024" "1.059" "0.947" "1.031" "0.964" "1.039" "1.494" "126.3" "129.5" "121.7" "129.4" "133.8" "119.6" "130.2" "121.8" "131.3" "188.8" "" "" "" "" "" "" "" "" "" "" "112.0" "107.3" "106.2" "96.8" "111.6" "109.9" "110.0" "100.6" "120.4" "188.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7265120983656370207" "False" "High" "IsMasterProtein" "Q6UW02" "Cytochrome P450 20A1 OS=Homo sapiens OX=9606 GN=CYP20A1 PE=1 SV=1" "0.001" "False" "4.682" "3" "1" "1" "1" "462" "52.4" "6.21" "2.72" "1" "" "" "other molecular function" "Pf00067" "57404" "ENSG00000119004" "CYP20A1" "hsa:57404; Q4ZG61; Q6UW02; Q8N4Q8; Q8WWA9; Q9HC04" "" "Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3693927105284752226" "False" "High" "IsMasterProtein" "Cont_Q3ZBS7" "Vitronectin OS=Bos taurus OX=9913 GN=VTN PE=1 SV=1" "0.001" "True" "4.674" "7" "3" "3" "3" "476" "53.5" "6.28" "5.25" "3" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00045, Pf01033" "507525" "ENSBIXG00000028629; ENSBTAG00000016151" "VTN" "A0A4W2E672; bta:507525; Q3ZBS7" "Integrin cell surface interactions; ECM proteoglycans; Molecules associated with elastic fibres; Syndecan interactions; Regulation of Complement cascade" "Inflammatory response pathway; Focal adhesion; Primary focal segmental glomerulosclerosis (FSGS)" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5334275938705899592" "False" "High" "IsMasterProtein" "O00512" "B-cell CLL/lymphoma 9 protein OS=Homo sapiens OX=9606 GN=BCL9 PE=1 SV=4" "0.001" "False" "4.666" "2" "3" "3" "3" "1426" "149.2" "8.91" "4.86" "3" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf11502" "607" "ENSG00000116128" "BCL9" "hsa:607; O00512; Q5T489" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome" "5" "0" "0.724" "0.727" "0.645" "0.583" "0.484" "0.762" "0.939" "0.977" "0.405" "17.3" "12.5" "12.6" "11.2" "10.1" "8.4" "13.2" "16.3" "16.9" "7.0" "" "" "" "" "" "" "" "" "" "" "15.3" "10.4" "11.0" "8.4" "8.4" "7.7" "11.2" "13.4" "15.5" "7.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4904792924861238037" "False" "High" "IsMasterProtein" "Q9Y5J6" "Mitochondrial import inner membrane translocase subunit Tim10 B OS=Homo sapiens OX=9606 GN=TIMM10B PE=1 SV=1" "0.001" "False" "4.663" "9" "1" "2" "1" "103" "11.6" "7.43" "7.08" "1" "cell adhesion;cell organization and biogenesis;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26515" "ENSG00000132286" "TIMM10B" "hsa:26515; Q96FF3; Q9Y5J6" "Mitochondrial protein import" "" "1" "0" "0.936" "1.026" "1.032" "0.984" "1.093" "0.982" "0.861" "0.960" "0.466" "129.4" "121.1" "132.7" "133.5" "127.3" "141.4" "127.0" "111.4" "124.2" "60.3" "" "" "" "" "" "" "" "" "" "" "114.7" "100.3" "115.8" "99.9" "106.1" "129.9" "107.4" "92.1" "113.9" "60.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8019113709048034538" "False" "High" "IsMasterProtein" "Q9NPE3" "H/ACA ribonucleoprotein complex subunit 3 OS=Homo sapiens OX=9606 GN=NOP10 PE=1 SV=1" "0.001" "False" "4.663" "25" "1" "1" "1" "64" "7.7" "9.99" "3.22" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04135" "55505" "ENSG00000182117; ENSG00000291996" "NOP10" "hsa:55505; Q9NPE3" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4408499482478688157" "False" "High" "IsMasterProtein" "Q9Y4X4" "Krueppel-like factor 12 OS=Homo sapiens OX=9606 GN=KLF12 PE=1 SV=2" "0.001" "False" "4.649" "3" "1" "1" "1" "402" "44.2" "9.70" "3.59" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "11278" "ENSG00000118922" "KLF12" "A8K5T2; hsa:11278; L0R3J4; Q5VZM7; Q9UHZ0; Q9Y4X4" "" "" "0" "0" "0.901" "0.880" "1.159" "0.989" "0.689" "1.043" "0.916" "0.791" "0.786" "146.5" "131.9" "128.9" "169.8" "144.9" "100.9" "152.8" "134.2" "115.8" "115.2" "" "" "" "" "" "" "" "" "" "" "129.9" "109.3" "112.4" "127.0" "120.8" "92.7" "129.1" "110.9" "106.2" "115.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758268738613076417" "False" "High" "IsMasterProtein" "Q9HBM0" "Vezatin OS=Homo sapiens OX=9606 GN=VEZT PE=1 SV=3" "0.001" "False" "4.648" "1" "1" "1" "1" "779" "88.6" "5.20" "2.72" "1" "cell adhesion" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity" "Pf12632" "55591" "ENSG00000028203" "VEZT" "hsa:55591; Q6P1Q3; Q9H2F4; Q9H2U5; Q9HBM0; Q9NT70; Q9NVW0; Q9UF91" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2427980612750648457" "False" "High" "IsMasterProtein" "P21359" "Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2" "0.001" "False" "4.645" "0" "1" "1" "1" "2839" "319.2" "7.39" "3.27" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf13716" "4763" "ENSG00000196712" "NF1" "hsa:4763; O00662; P21359; Q14284; Q14930; Q14931; Q9UMK3" "Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants" "Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance; NF1 copy number variation syndrome" "14" "0" "0.755" "0.838" "1.161" "0.827" "1.048" "0.827" "0.620" "0.910" "4.177" "46.9" "35.4" "39.3" "54.5" "38.8" "49.1" "38.8" "29.1" "42.7" "195.9" "" "" "" "" "" "" "" "" "" "" "41.6" "29.3" "34.3" "40.7" "32.3" "45.1" "32.8" "24.0" "39.1" "195.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3933155493213774730" "False" "High" "IsMasterProtein" "Cont_Q3SZV7" "Hemopexin OS=Bos taurus OX=9913 GN=HPX PE=2 SV=1" "0.001" "True" "4.622" "5" "3" "3" "3" "459" "52.2" "7.80" "7.81" "3" "other metabolic processes;transport;other biological processes" "non-structural extracellular" "transporter activity;other molecular function" "Pf00045" "534509" "ENSBIXG00000017851" "HPX" "A0A4W2EKG5; bta:534509; Q3SZV7" "" "" "0" "0" "1.050" "0.979" "0.939" "0.979" "0.921" "0.977" "0.886" "0.906" "0.742" "166.9" "175.2" "163.3" "156.7" "163.3" "153.7" "163.0" "147.9" "151.2" "123.8" "" "" "" "" "" "" "" "" "" "" "148.0" "145.1" "142.5" "117.2" "136.2" "141.1" "137.7" "122.2" "138.6" "123.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.001" "False" "4.620" "4" "1" "1" "1" "221" "26.1" "9.79" "3.91" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "0.997" "1.023" "1.111" "1.109" "0.878" "1.040" "0.914" "0.990" "0.463" "152.9" "152.5" "156.4" "169.9" "169.6" "134.2" "159.0" "139.7" "151.4" "70.8" "" "" "" "" "" "" "" "" "" "" "135.6" "126.3" "136.4" "127.1" "141.4" "123.3" "134.3" "115.5" "138.8" "70.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.001" "False" "4.616" "4" "1" "1" "1" "293" "34.2" "9.88" "4.72" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676225974724489617" "False" "High" "IsMasterProtein" "P02458" "Collagen alpha-1(II) chain OS=Homo sapiens OX=9606 GN=COL2A1 PE=1 SV=3" "0.001" "False" "4.616" "1" "2" "2" "2" "1487" "141.7" "6.92" "5.79" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00093, Pf01391, Pf01410" "1280" "ENSG00000139219" "COL2A1" "A6NGA0; hsa:1280; P02458; Q12985; Q14009; Q14044; Q14045; Q14046; Q14047; Q14056; Q14058; Q16672; Q1JQ82; Q2V4X7; Q6LBY1; Q6LBY2; Q6LBY3; Q96IT5; Q99227; Q9UE38; Q9UE39; Q9UE40; Q9UE41; Q9UE42; Q9UE43" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling" "Neural crest differentiation; Spinal cord injury; Focal adhesion; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Urotensin-II-mediated signaling pathway; 2q11.2 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "23" "0" "1.917" "0.864" "2.004" "1.106" "2.683" "1.099" "0.951" "1.526" "0.704" "64.4" "123.4" "55.6" "129.0" "71.2" "172.7" "70.8" "61.3" "98.3" "45.3" "" "" "" "" "" "" "" "" "" "" "57.1" "102.2" "48.5" "96.5" "59.4" "158.7" "59.8" "50.6" "90.1" "45.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537726358648831558" "False" "High" "IsMasterProtein" "Q5U649" "Uncharacterized protein C12orf60 OS=Homo sapiens OX=9606 GN=C12orf60 PE=1 SV=2" "0.001" "False" "4.615" "4" "1" "1" "1" "245" "27.6" "7.96" "3.17" "1" "" "" "" "Pf15047" "144608" "ENSG00000182993" "C12orf60" "A8K1M7; hsa:144608; Q5U649; Q5XKK8; Q8IXY2" "" "" "0" "0" "1.191" "1.086" "1.221" "1.057" "1.074" "1.347" "1.225" "1.133" "2.086" "24.4" "29.1" "26.5" "29.8" "25.8" "26.3" "32.9" "30.0" "27.7" "51.0" "" "" "" "" "" "" "" "" "" "" "21.7" "24.1" "23.2" "22.3" "21.5" "24.1" "27.8" "24.8" "25.4" "51.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245887775356859101" "False" "High" "IsMasterProtein" "Q8N0Z6" "Tetratricopeptide repeat protein 5 OS=Homo sapiens OX=9606 GN=TTC5 PE=1 SV=2" "0.001" "False" "4.613" "6" "2" "2" "2" "440" "48.9" "6.48" "2.30" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf16669" "91875" "ENSG00000136319; ENSG00000291781" "TTC5" "A8MQ18; hsa:91875; Q8N0Z6; Q96HF9" "Regulation of TP53 Activity through Methylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827315428998804752" "False" "High" "IsMasterProtein" "Q9H9L4" "KAT8 regulatory NSL complex subunit 2 OS=Homo sapiens OX=9606 GN=KANSL2 PE=1 SV=3" "0.001" "False" "4.613" "2" "1" "1" "1" "492" "55.0" "6.62" "4.42" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf13891" "54934" "ENSG00000139620" "KANSL2" "hsa:54934; Q8N3B5; Q96CV0; Q9H9L4; Q9NX51" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "" "2" "0" "0.819" "0.821" "0.986" "0.739" "0.829" "0.808" "0.464" "0.813" "4.390" "79.2" "64.9" "65.1" "78.2" "58.5" "65.7" "64.0" "36.8" "64.4" "347.8" "" "" "" "" "" "" "" "" "" "" "70.3" "53.8" "56.8" "58.5" "48.8" "60.3" "54.1" "30.4" "59.1" "347.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3143517004493314389" "False" "High" "IsMasterProtein" "Q01970" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2" "0.001" "False" "4.596" "1" "1" "1" "1" "1234" "138.7" "5.90" "2.13" "1" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5331" "ENSG00000149782" "PLCB3" "A5PKZ6; G5E960; hsa:5331; Q01970; Q8N1A4" "G alpha (q) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; Synthesis of IP3 and IP4 in the cytosol; PLC beta mediated events; Acetylcholine regulates insulin secretion" "Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells" "26" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1215662422717985133" "False" "High" "IsMasterProtein" "Q8NG27" "E3 ubiquitin-protein ligase Praja-1 OS=Homo sapiens OX=9606 GN=PJA1 PE=1 SV=2" "0.001" "False" "4.583" "3" "2" "3" "1" "643" "71.0" "5.17" "8.33" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "64219" "ENSG00000181191" "PJA1" "A2A322; Q5JUT8; Q5JUT9; Q8NG27; Q8NG28; Q9HAC1" "Antigen processing: Ubiquitination & Proteasome degradation" "TGF-beta signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4924966722197614232" "False" "High" "IsMasterProtein" "Q8TB37" "Iron-sulfur cluster transfer protein NUBPL OS=Homo sapiens OX=9606 GN=NUBPL PE=1 SV=3" "0.001" "False" "4.579" "3" "1" "1" "1" "319" "34.1" "9.04" "3.99" "1" "cell organization and biogenesis" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf10609" "80224" "ENSG00000151413" "NUBPL" "B4DHZ1; hsa:80224; Q86TZ4; Q8TB37; Q9H9M2" "Complex I biogenesis" "Epithelial to mesenchymal transition in colorectal cancer" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486403724056782188" "False" "High" "IsMasterProtein" "Q7L8L6" "FAST kinase domain-containing protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD5 PE=1 SV=1" "0.001" "False" "4.574" "1" "1" "1" "1" "764" "86.5" "8.13" "4.08" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "60493" "ENSG00000215251" "FASTKD5" "hsa:60493; Q7L8L6; Q96JN3; Q9H5D1; Q9H8Y3" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "0.803" "0.855" "1.227" "0.772" "1.035" "0.798" "0.010" "0.839" "18.698" "42.2" "33.9" "36.1" "51.8" "32.6" "43.7" "33.7" "0.0" "35.5" "789.6" "" "" "" "" "" "" "" "" "" "" "37.5" "28.1" "31.5" "38.8" "27.2" "40.2" "28.5" "0.0" "32.5" "789.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "-5620775136701769242" "False" "High" "IsMasterProtein" "P61764" "Syntaxin-binding protein 1 OS=Homo sapiens OX=9606 GN=STXBP1 PE=1 SV=1" "0.001" "False" "4.574" "2" "1" "1" "1" "594" "67.5" "6.96" "3.70" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00995" "6812" "ENSG00000136854" "STXBP1" "B1AM97; hsa:6812; P61764; Q28208; Q62759; Q64320; Q68CM6; Q96TG8" "Regulation of insulin secretion; Neurexins and neuroligins" "Synaptic vesicle pathway; Rett syndrome; EGF/EGFR signaling pathway; Insulin signaling; 15q11q13 copy number variation" "7" "0" "1.041" "0.826" "1.319" "1.182" "1.065" "1.057" "0.402" "1.066" "10.419" "79.7" "83.0" "65.8" "105.1" "94.2" "84.9" "84.3" "32.1" "85.0" "830.5" "" "" "" "" "" "" "" "" "" "" "70.7" "68.7" "57.4" "78.6" "78.5" "78.0" "71.2" "26.5" "77.9" "830.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3560652470776637886" "False" "High" "IsMasterProtein" "O43567" "E3 ubiquitin-protein ligase RNF13 OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1" "0.001" "False" "4.573" "4" "2" "2" "2" "381" "42.8" "4.98" "5.44" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02225, Pf13639" "11342" "ENSG00000082996" "RNF13" "A6NC87; B3KR12; hsa:11342; O43567; Q05D66; Q6IBJ9" "" "" "0" "0" "0.982" "0.955" "0.960" "0.939" "1.077" "0.909" "0.997" "0.920" "0.742" "309.6" "304.2" "295.6" "297.2" "290.6" "333.5" "281.5" "308.7" "284.8" "229.8" "" "" "" "" "" "" "" "" "" "" "274.6" "252.0" "258.0" "222.3" "242.3" "306.3" "237.9" "255.1" "261.2" "229.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1188188450162600285" "False" "High" "IsMasterProtein" "Q9HBT7" "Zinc finger protein 287 OS=Homo sapiens OX=9606 GN=ZNF287 PE=1 SV=2" "0.001" "False" "4.572" "2" "2" "3" "1" "761" "88.3" "8.56" "9.16" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf02023" "57336" "ENSG00000141040" "ZNF287" "hsa:57336; Q6IAG1; Q9HBT7" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331162755834209068" "False" "High" "IsMasterProtein" "Q8IWR0" "Zinc finger CCCH domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZC3H7A PE=1 SV=1" "0.001" "False" "4.567" "1" "1" "1" "1" "971" "110.5" "7.30" "3.56" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642" "29066" "ENSG00000122299" "ZC3H7A" "D3DUG5; hsa:29066; Q8IWR0; Q9NPE9" "" "" "0" "0" "0.913" "0.793" "0.978" "0.893" "0.720" "0.891" "0.274" "1.014" "11.028" "67.6" "61.7" "53.7" "66.1" "60.4" "48.7" "60.3" "18.5" "68.6" "745.9" "" "" "" "" "" "" "" "" "" "" "60.0" "51.1" "46.8" "49.5" "50.4" "44.7" "50.9" "15.3" "62.9" "745.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350919195755169841" "False" "High" "IsMasterProtein" "Q969Q6" "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Homo sapiens OX=9606 GN=PPP2R3C PE=1 SV=1" "0.001" "False" "4.564" "4" "2" "2" "1" "453" "53.3" "5.19" "6.51" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf17958" "55012" "ENSG00000092020" "PPP2R3C" "B4DEN7; D3DS97; D3DS98; hsa:55012; Q5GJ55; Q5GJ56; Q6P4G2; Q86TZ3; Q969Q6; Q9NWR9" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1034652218568526066" "False" "High" "IsMasterProtein" "Q66GS9" "Centrosomal protein of 135 kDa OS=Homo sapiens OX=9606 GN=CEP135 PE=1 SV=2" "0.001" "False" "4.546" "1" "1" "1" "1" "1140" "133.4" "6.21" "3.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "9662" "ENSG00000174799" "CEP135" "B2RMY0; hsa:9662; O75130; Q58F25; Q66GS9; Q9H8H7" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.001" "False" "4.545" "2" "1" "1" "1" "615" "70.7" "9.36" "3.15" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1010255364249056009" "False" "High" "IsMasterProtein" "Q9H5H4" "Zinc finger protein 768 OS=Homo sapiens OX=9606 GN=ZNF768 PE=1 SV=2" "0.001" "False" "4.529" "4" "2" "3" "1" "540" "60.2" "7.97" "8.84" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf05001" "79724" "ENSG00000169957" "ZNF768" "hsa:79724; Q569L7; Q96CX4; Q9H5H4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847329680640326989" "False" "High" "IsMasterProtein" "Q8NDI1" "EH domain-binding protein 1 OS=Homo sapiens OX=9606 GN=EHBP1 PE=1 SV=3" "0.001" "False" "4.524" "1" "2" "3" "1" "1231" "139.9" "5.35" "8.70" "2" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "23301" "ENSG00000115504" "EHBP1" "hsa:23301; O94977; Q53TG7; Q53TV6; Q580X2; Q6NX72; Q6PIT3; Q6QNV2; Q8NDI1; Q9NWI9" "" "Ciliary landscape" "1" "0" "0.963" "0.953" "1.060" "0.862" "1.018" "0.967" "0.878" "1.156" "2.555" "36.2" "34.8" "34.5" "38.3" "31.2" "36.8" "35.0" "31.7" "41.8" "92.4" "" "" "" "" "" "" "" "" "" "" "32.1" "28.8" "30.1" "28.6" "26.0" "33.8" "29.5" "26.2" "38.3" "92.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875234499947995187" "False" "High" "IsMasterProtein" "Q93100" "Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB PE=1 SV=3" "0.001" "False" "4.504" "1" "1" "1" "1" "1093" "124.8" "6.95" "4.07" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00723, Pf19292" "5257" "ENSG00000102893" "PHKB" "hsa:5257; Q8N4T5; Q93100" "Glycogen breakdown (glycogenolysis)" "Glycogen synthesis and degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4837224883862522345" "False" "High" "IsMasterProtein" "Q9BYD1" "Large ribosomal subunit protein uL13m OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "0.001" "False" "4.503" "8" "1" "1" "1" "178" "20.7" "9.16" "4.85" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.011" "1.035" "1.108" "1.110" "0.905" "1.158" "1.080" "1.201" "2.963" "190.5" "192.6" "197.2" "211.2" "211.6" "172.5" "220.7" "205.7" "228.7" "564.5" "" "" "" "" "" "" "" "" "" "" "169.0" "159.5" "172.1" "157.9" "176.4" "158.5" "186.5" "170.0" "209.8" "564.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2389854899245022230" "False" "High" "IsMasterProtein" "A6NDU8" "RAB7A-interacting MON1-CCZ1 complex subunit 1 OS=Homo sapiens OX=9606 GN=RIMOC1 PE=1 SV=1" "0.001" "False" "4.502" "3" "1" "1" "1" "294" "33.6" "5.26" "4.14" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "" "Pf17716" "285636" "ENSG00000205765" "RIMOC1" "A2RRM9; A6NDU8; hsa:285636" "" "" "0" "0" "1.008" "1.072" "1.020" "1.007" "1.032" "0.961" "0.814" "0.957" "3.199" "89.0" "89.7" "95.5" "90.8" "89.6" "91.9" "85.5" "72.5" "85.2" "284.8" "" "" "" "" "" "" "" "" "" "" "79.0" "74.3" "83.3" "67.9" "74.7" "84.4" "72.3" "59.9" "78.1" "284.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3653406019681218238" "False" "High" "IsMasterProtein" "Q07002" "Cyclin-dependent kinase 18 OS=Homo sapiens OX=9606 GN=CDK18 PE=1 SV=4" "0.001" "False" "4.500" "4" "2" "2" "1" "474" "54.4" "8.66" "5.61" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5129" "ENSG00000117266" "CDK18" "hsa:5129; Q07002; Q5VXQ2; Q6V3A2; Q6V3A3; Q96F90" "" "" "0" "0" "0.746" "0.997" "0.818" "0.736" "0.660" "0.875" "0.700" "0.622" "0.865" "240.3" "179.3" "239.5" "196.6" "176.9" "158.6" "210.3" "168.1" "149.5" "207.8" "" "" "" "" "" "" "" "" "" "" "213.1" "148.5" "209.0" "147.0" "147.5" "145.7" "177.7" "138.9" "137.1" "207.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139328666383470964" "False" "High" "IsMasterProtein" "Q8IZH2" "5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1" "0.001" "False" "4.500" "1" "1" "1" "1" "1706" "194.0" "7.21" "3.11" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846, Pf18129, Pf18332, Pf18334" "54464" "ENSG00000114127" "XRN1" "hsa:54464; Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8IZH2; Q8N8U4; Q9UF39" "mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "miRNA degrading enzymes" "4" "0" "1.305" "1.086" "1.258" "1.234" "1.045" "1.272" "1.015" "1.336" "2.269" "14.7" "19.2" "16.0" "18.5" "18.2" "15.4" "18.7" "15.0" "19.7" "33.4" "" "" "" "" "" "" "" "" "" "" "13.1" "15.9" "14.0" "13.9" "15.2" "14.2" "15.8" "12.4" "18.1" "33.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479231618500312272" "False" "High" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0.001" "False" "4.493" "0" "2" "2" "2" "8797" "1010.5" "5.53" "5.40" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Meiotic synapsis" "Envelope proteins and their potential roles in EDMD physiopathology" "2" "0" "1.021" "0.906" "1.096" "1.134" "0.892" "0.996" "1.013" "0.918" "0.491" "52.6" "53.7" "47.7" "57.7" "59.7" "46.9" "52.4" "53.3" "48.3" "25.8" "" "" "" "" "" "" "" "" "" "" "46.7" "44.5" "41.6" "43.1" "49.8" "43.1" "44.3" "44.1" "44.3" "25.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3163566102457861060" "False" "High" "IsMasterProtein" "Q8IWI9" "MAX gene-associated protein OS=Homo sapiens OX=9606 GN=MGA PE=1 SV=4" "0.001" "False" "4.491" "0" "1" "1" "1" "3065" "336.0" "6.90" "3.03" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00907, Pf16059" "23269" "ENSG00000174197" "MGA" "B9EGR5; E7ENI0; F5H7K2; hsa:23269; Q8IWI9; Q9H8R3; Q9H9N7; Q9UG69; Q9Y4E9" "Transcriptional Regulation by E2F6" "Pathways affected in adenoid cystic carcinoma" "2" "0" "0.865" "0.784" "0.824" "0.758" "0.908" "0.819" "0.842" "0.779" "1.575" "137.3" "118.8" "107.6" "113.1" "104.1" "124.7" "112.5" "115.6" "107.0" "216.2" "" "" "" "" "" "" "" "" "" "" "121.8" "98.4" "93.9" "84.6" "86.8" "114.5" "95.1" "95.6" "98.1" "216.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9022447495493908816" "False" "High" "IsMasterProtein" "O75381" "Peroxisomal membrane protein PEX14 OS=Homo sapiens OX=9606 GN=PEX14 PE=1 SV=1" "0.001" "False" "4.487" "2" "1" "1" "1" "377" "41.2" "4.94" "4.24" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf04695" "5195" "ENSG00000142655" "PEX14" "B2R7N1; B3KML6; B7Z1N2; hsa:5195; O75381; Q8WX51" "E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; Class I peroxisomal membrane protein import" "" "3" "0" "0.974" "0.951" "0.962" "0.969" "0.930" "1.021" "0.873" "0.976" "0.532" "223.3" "217.6" "212.4" "214.9" "216.4" "207.8" "227.9" "195.0" "218.0" "118.8" "" "" "" "" "" "" "" "" "" "" "198.0" "180.2" "185.3" "160.7" "180.4" "190.8" "192.6" "161.2" "199.9" "118.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1911741891991956456" "False" "High" "IsMasterProtein" "Q9NX14" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB11 PE=1 SV=1" "0.001" "False" "4.486" "7" "1" "1" "1" "153" "17.3" "5.22" "3.99" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion" "" "Pf10183" "54539" "ENSG00000147123" "NDUFB11" "hsa:54539; Q5JRR3; Q5JRR4; Q6IAB6; Q8WZ96; Q9BXX9; Q9NX14" "Complex I biogenesis" "Nonalcoholic fatty liver disease" "3" "0" "1.072" "0.941" "1.065" "1.134" "1.136" "1.300" "1.254" "1.321" "0.534" "138.8" "148.8" "130.6" "147.9" "157.4" "157.7" "180.5" "174.1" "183.3" "74.1" "" "" "" "" "" "" "" "" "" "" "123.1" "123.3" "113.9" "110.6" "131.3" "144.9" "152.5" "143.9" "168.1" "74.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3789588988762427283" "False" "High" "IsMasterProtein" "Q96FH0" "BLOC-1-related complex subunit 8 OS=Homo sapiens OX=9606 GN=BORCS8 PE=1 SV=1" "0.001" "False" "4.475" "13" "2" "2" "2" "119" "13.4" "5.80" "5.95" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10167" "729991" "ENSG00000254901" "BORCS8" "B2RXF9; hsa:729991; Q96FH0; Q9BT01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531669477434534246" "False" "High" "IsMasterProtein" "Q9NX01" "Thioredoxin-like protein 4B OS=Homo sapiens OX=9606 GN=TXNL4B PE=1 SV=1" "0.001" "False" "4.475" "13" "2" "3" "2" "149" "17.0" "6.00" "8.08" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf02966" "54957" "ENSG00000140830" "TXNL4B" "D3DWS6; hsa:54957; Q9NX01" "" "" "0" "0" "1.063" "1.004" "0.993" "0.937" "0.953" "0.926" "0.948" "0.976" "1.505" "362.2" "384.9" "363.5" "359.8" "339.4" "345.3" "335.4" "343.3" "353.6" "545.3" "" "" "" "" "" "" "" "" "" "" "321.2" "318.9" "317.2" "269.1" "283.0" "317.2" "283.5" "283.8" "324.3" "545.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6959452537761872804" "False" "High" "IsMasterProtein" "Q8TB45" "DEP domain-containing mTOR-interacting protein OS=Homo sapiens OX=9606 GN=DEPTOR PE=1 SV=2" "0.001" "False" "4.474" "4" "2" "2" "2" "409" "46.3" "8.07" "5.22" "2" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00610" "64798" "ENSG00000155792" "DEPTOR" "B2RCL9; B4DN97; E7EV87; hsa:64798; Q8TB45; Q96EQ1; Q9H0R7; Q9H894; Q9HA07" "" "Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Clear cell renal cell carcinoma pathways; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; ADHD and autism (ASD) linked metabolic pathways and SNP" "10" "0" "0.873" "0.975" "1.092" "0.815" "0.985" "0.799" "0.614" "0.925" "5.883" "46.3" "40.4" "45.1" "50.6" "37.7" "45.6" "37.0" "28.4" "42.8" "272.4" "" "" "" "" "" "" "" "" "" "" "41.1" "33.5" "39.4" "37.8" "31.5" "41.9" "31.3" "23.5" "39.3" "272.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407344682093019997" "False" "High" "IsMasterProtein" "Q53GL0" "Pleckstrin homology domain-containing family O member 1 OS=Homo sapiens OX=9606 GN=PLEKHO1 PE=1 SV=2" "0.001" "False" "4.474" "4" "2" "2" "2" "409" "46.2" "8.82" "5.91" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf00169" "51177" "ENSG00000023902" "PLEKHO1" "hsa:51177; Q336K5; Q53GL0; Q8IZ51; Q9NRV3; Q9UL48" "" "" "0" "0" "1.066" "1.357" "1.092" "0.960" "0.985" "0.929" "0.930" "0.966" "0.901" "77.4" "82.5" "105.1" "84.6" "74.3" "76.2" "71.9" "72.0" "74.8" "69.7" "" "" "" "" "" "" "" "" "" "" "68.6" "68.3" "91.7" "63.2" "62.0" "70.0" "60.8" "59.5" "68.6" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7798556211851200264" "False" "High" "IsMasterProtein" "Q96AX1" "Vacuolar protein sorting-associated protein 33A OS=Homo sapiens OX=9606 GN=VPS33A PE=1 SV=1" "0.001" "False" "4.462" "3" "2" "3" "2" "596" "67.6" "6.96" "4.95" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00995" "65082" "ENSG00000139719" "VPS33A" "Q547V4; Q96AX1; Q9H5Q0" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Network map of SARS-CoV-2 signaling pathway" "4" "0" "0.714" "0.715" "1.112" "0.900" "0.671" "0.634" "0.766" "0.705" "1.440" "14.1" "10.1" "10.1" "15.7" "12.7" "9.5" "8.9" "10.8" "9.9" "20.3" "" "" "" "" "" "" "" "" "" "" "12.5" "8.3" "8.8" "11.7" "10.6" "8.7" "7.6" "8.9" "9.1" "20.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703778072310238355" "False" "High" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "0.001" "False" "4.462" "2" "1" "2" "1" "576" "60.3" "4.83" "4.28" "1" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "366998149904199311" "False" "High" "IsMasterProtein" "P79522" "Proline-rich protein 3 OS=Homo sapiens OX=9606 GN=PRR3 PE=1 SV=2" "0.001" "False" "4.462" "5" "1" "1" "1" "188" "20.6" "9.83" "3.99" "1" "" "" "other molecular function" "Pf00642" "80742" "ENSG00000204576; ENSG00000206491; ENSG00000223766; ENSG00000223887; ENSG00000228186; ENSG00000229202; ENSG00000233564" "PRR3" "A1A4H4; hsa:80742; P79522; Q5RJB5; Q5STN6" "" "" "0" "0" "1.005" "0.966" "0.963" "0.979" "1.077" "0.982" "0.902" "0.905" "1.324" "255.0" "256.3" "246.4" "245.4" "249.6" "274.6" "250.5" "230.1" "230.8" "337.5" "" "" "" "" "" "" "" "" "" "" "226.1" "212.3" "215.0" "183.6" "208.1" "252.2" "211.7" "190.2" "211.7" "337.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256075444160653012" "False" "High" "IsMasterProtein" "Q5SVZ6" "Zinc finger MYM-type protein 1 OS=Homo sapiens OX=9606 GN=ZMYM1 PE=1 SV=1" "0.001" "False" "4.462" "1" "1" "1" "1" "1142" "128.6" "7.44" "3.74" "1" "" "nucleus" "other molecular function" "Pf05699, Pf06467, Pf14291" "79830" "ENSG00000197056" "ZMYM1" "D3DPR7; hsa:79830; Q5SVZ6; Q7Z3Q4" "" "" "0" "0" "0.988" "0.903" "1.169" "0.928" "1.006" "0.904" "0.722" "0.996" "1.765" "44.1" "43.6" "39.9" "51.6" "41.0" "44.4" "39.9" "31.9" "43.9" "77.9" "" "" "" "" "" "" "" "" "" "" "39.1" "36.1" "34.8" "38.6" "34.2" "40.8" "33.7" "26.3" "40.3" "77.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2915122001344888094" "False" "High" "IsMasterProtein" "Q13136" "Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1" "0.001" "False" "4.460" "1" "2" "2" "1" "1202" "135.7" "6.29" "5.52" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00536, Pf07647" "8500" "ENSG00000131626; ENSG00000288198" "PPFIA1" "A6NLE3; hsa:8500; Q13135; Q13136; Q14567; Q8N4I2" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "Cell lineage map for neuronal differentiation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2247298943909741836" "False" "High" "IsMasterProtein" "Q5C9Z4" "Nucleolar MIF4G domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOM1 PE=1 SV=1" "0.001" "False" "4.459" "2" "1" "1" "1" "860" "96.2" "8.10" "3.63" "1" "other biological processes" "nucleus" "" "Pf02847, Pf02854" "64434" "ENSG00000146909" "NOM1" "hsa:64434; Q5C9Z4; Q96I08" "" "" "0" "0" "0.823" "0.722" "0.855" "0.777" "0.806" "0.836" "0.618" "0.768" "1.435" "46.9" "38.6" "33.9" "40.1" "36.4" "37.8" "39.2" "29.0" "36.0" "67.3" "" "" "" "" "" "" "" "" "" "" "41.6" "32.0" "29.6" "30.0" "30.4" "34.7" "33.1" "24.0" "33.0" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1789313073450950606" "False" "High" "IsMasterProtein" "Q9BSR8" "Protein YIPF4 OS=Homo sapiens OX=9606 GN=YIPF4 PE=1 SV=1" "0.001" "False" "4.458" "4" "1" "1" "1" "244" "27.1" "4.65" "3.82" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf04893" "84272" "ENSG00000119820" "YIPF4" "hsa:84272; Q9BSR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225223608593832705" "False" "High" "IsMasterProtein" "Q99856" "AT-rich interactive domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ARID3A PE=1 SV=2" "0.001" "False" "4.454" "2" "1" "1" "1" "593" "62.9" "4.91" "4.82" "1" "other biological processes" "other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01388" "1820" "ENSG00000116017" "ARID3A" "hsa:1820; Q5I858; Q6P9C6; Q8IZA7; Q8N4Z3; Q99856" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" "HDAC6 interactions in the central nervous system" "2" "0" "0.940" "0.870" "0.958" "0.890" "0.774" "0.836" "0.787" "0.890" "2.619" "84.3" "79.3" "73.4" "80.8" "75.1" "65.3" "70.5" "66.3" "75.1" "220.8" "" "" "" "" "" "" "" "" "" "" "74.8" "65.6" "64.0" "60.4" "62.6" "60.0" "59.6" "54.8" "68.8" "220.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572766235015133310" "False" "High" "IsMasterProtein" "P42771" "Cyclin-dependent kinase inhibitor 2A OS=Homo sapiens OX=9606 GN=CDKN2A PE=1 SV=2" "0.001" "False" "4.453" "8" "1" "1" "1" "156" "16.5" "5.81" "3.38" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "1029" "ENSG00000147889" "CDKN2A" "A5X2G7; D3DRK1; G3XAG3; hsa:1029; O95440; P42771; Q15191; Q5VVJ5; Q96B52; Q9NP05" "Cyclin D associated events in G1; Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6" "TP53 network; Cell cycle; Glioblastoma signaling pathways; Apoptosis; Bladder cancer; Vitamin D receptor pathway; Photodynamic therapy-induced AP-1 survival signaling; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Fragile X syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Melanoma; Pleural mesothelioma; TROP2 regulatory signaling" "26" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8443546389451323737" "False" "High" "IsMasterProtein" "Q96HJ9" "Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2" "0.001" "False" "4.452" "11" "1" "1" "1" "113" "12.7" "10.07" "3.98" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "" "Pf13233" "100996928; 154791" "ENSG00000164898" "FMC1" "B7Z4Q3; hsa:100996928; hsa:154791; Q75M90; Q96HJ9; Q9P0B3" "" "" "0" "0" "1.036" "0.984" "1.105" "1.146" "1.102" "1.054" "1.044" "1.004" "0.442" "183.4" "190.1" "180.5" "202.7" "210.2" "202.1" "193.4" "191.5" "184.2" "81.0" "" "" "" "" "" "" "" "" "" "" "162.7" "157.5" "157.5" "151.6" "175.3" "185.7" "163.4" "158.3" "168.9" "81.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1676018771169478995" "False" "High" "IsMasterProtein" "O60293" "Zinc finger C3H1 domain-containing protein OS=Homo sapiens OX=9606 GN=ZFC3H1 PE=1 SV=3" "0.001" "False" "4.449" "0" "1" "1" "1" "1989" "226.2" "8.13" "3.19" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10650" "196441" "ENSG00000133858" "ZFC3H1" "hsa:196441; O60293; Q6GMU1; Q6P2S9; Q6ZV36; Q96BE7" "" "" "0" "0" "0.990" "0.812" "1.124" "1.106" "0.909" "1.213" "0.977" "0.967" "3.752" "92.7" "91.8" "75.3" "104.2" "102.6" "84.3" "112.5" "90.6" "89.6" "348.0" "" "" "" "" "" "" "" "" "" "" "82.2" "76.0" "65.7" "77.9" "85.5" "77.4" "95.1" "74.9" "82.2" "348.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949568928941647536" "False" "High" "IsMasterProtein" "O43676" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 OS=Homo sapiens OX=9606 GN=NDUFB3 PE=1 SV=3" "0.001" "False" "4.440" "11" "1" "1" "1" "98" "11.4" "9.20" "5.25" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf08122" "4709" "ENSG00000119013" "NDUFB3" "hsa:4709; O43676; Q6IB80" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease" "4" "0" "1.141" "1.130" "1.177" "1.185" "1.190" "1.138" "1.117" "1.269" "0.384" "154.8" "176.6" "174.9" "182.3" "183.5" "184.2" "176.3" "173.0" "196.4" "59.5" "" "" "" "" "" "" "" "" "" "" "137.3" "146.3" "152.6" "136.3" "153.0" "169.2" "149.0" "143.0" "180.2" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7773127221767438121" "False" "High" "IsMasterProtein" "Q6AI39" "BRD4-interacting chromatin-remodeling complex-associated protein-like OS=Homo sapiens OX=9606 GN=BICRAL PE=1 SV=2" "0.001" "False" "4.432" "1" "1" "1" "1" "1079" "115.0" "6.87" "3.70" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf15249" "23506" "ENSG00000112624" "BICRAL" "A1L3W2; hsa:23506; Q5TFZ3; Q6AI39; Q92514" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8237731062455566207" "False" "High" "IsMasterProtein" "P40763" "Signal transducer and activator of transcription 3 OS=Homo sapiens OX=9606 GN=STAT3 PE=1 SV=2" "0.001" "False" "4.431" "2" "2" "2" "2" "770" "88.0" "6.30" "3.23" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6774" "ENSG00000168610" "STAT3" "A8K7B8; hsa:6774; K7ENL3; O14916; P40763; Q9BW54" "Downstream signal transduction; Transcriptional regulation of granulopoiesis; Interleukin-4 and Interleukin-13 signaling; Senescence-Associated Secretory Phenotype (SASP); PKR-mediated signaling; Signaling by ALK fusions and activated point mutants; Interleukin-7 signaling; Signaling by SCF-KIT; Signaling by ALK; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-10 signaling; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; PTK6 Activates STAT3; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; STAT3 nuclear events downstream of ALK signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-23 signaling; Interleukin-27 signaling; Interleukin-37 signaling; Signalling to STAT3; Nuclear events stimulated by ALK signaling in cancer; MET activates STAT3; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "IL-5 signaling pathway; Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Involution (Stage 4 of 4); Dopaminergic neurogenesis; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Estrogen receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Development of pulmonary dendritic cells and macrophage subsets; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Leptin-insulin signaling overlap; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Clear cell renal cell carcinoma pathways; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Extracellular vesicles in the crosstalk of cardiac cells; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Inflammatory bowel disease signaling; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Notch signaling pathway; Serotonin HTR1 group and FOS pathway" "119" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8212821940907449033" "False" "High" "IsMasterProtein" "A6NHX0" "Cytosolic arginine sensor for mTORC1 subunit 2 OS=Homo sapiens OX=9606 GN=CASTOR2 PE=1 SV=3" "0.001" "False" "4.420" "4" "1" "2" "1" "329" "36.0" "5.16" "5.71" "1" "other biological processes" "cytosol" "other molecular function" "Pf13840, Pf18700, Pf21389" "729438" "ENSG00000274070" "CASTOR2" "A6NHX0; A6NNH0; B9EJH9; hsa:729438" "Amino acids regulate mTORC1" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.001" "False" "4.418" "2" "1" "1" "1" "509" "58.8" "7.91" "3.91" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "12" "0" "1.089" "0.935" "1.235" "0.972" "1.033" "1.088" "0.884" "1.170" "4.846" "66.9" "72.9" "62.6" "82.6" "65.0" "69.2" "72.8" "59.1" "78.3" "324.2" "" "" "" "" "" "" "" "" "" "" "59.3" "60.4" "54.6" "61.8" "54.2" "63.5" "61.5" "48.9" "71.8" "324.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1171297253546326275" "False" "High" "IsMasterProtein" "Q6AI08" "HEAT repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=HEATR6 PE=1 SV=1" "0.001" "False" "4.400" "1" "1" "1" "1" "1181" "128.7" "7.03" "4.39" "1" "" "" "" "Pf13251" "63897" "ENSG00000068097" "HEATR6" "B3KXP3; hsa:63897; Q6AI08; Q6MZX1; Q6MZY2; Q8TDM9; Q9H6B3; Q9H6M7" "" "" "0" "0" "0.884" "0.849" "0.867" "0.840" "0.830" "0.972" "0.946" "1.014" "2.747" "251.4" "222.1" "213.3" "218.0" "211.2" "208.6" "244.3" "237.7" "254.8" "690.4" "" "" "" "" "" "" "" "" "" "" "222.9" "184.0" "186.2" "163.0" "176.1" "191.7" "206.4" "196.4" "233.7" "690.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1946096999683739252" "False" "High" "IsMasterProtein" "Q96LT7" "Guanine nucleotide exchange factor C9orf72 OS=Homo sapiens OX=9606 GN=C9orf72 PE=1 SV=2" "0.001" "False" "4.400" "3" "2" "2" "2" "481" "54.3" "6.23" "6.48" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf15019" "203228" "ENSG00000147894" "C9orf72" "A8K5W0; D3DRK6; G8I0B6; hsa:203228; Q6NUS9; Q96LT7" "" "Mesodermal commitment pathway" "1" "0" "1.087" "0.978" "1.122" "1.030" "1.006" "1.013" "1.055" "0.978" "0.766" "280.0" "304.5" "274.0" "314.3" "288.4" "281.7" "283.8" "295.6" "273.8" "214.6" "" "" "" "" "" "" "" "" "" "" "248.3" "252.3" "239.1" "235.0" "240.5" "258.8" "239.9" "244.3" "251.1" "214.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7698628990297234698" "False" "High" "IsMasterProtein" "Q9Y3D3" "Small ribosomal subunit protein bS16m OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "0.001" "False" "4.397" "9" "1" "1" "1" "137" "15.3" "9.50" "3.66" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.188" "1.079" "1.074" "1.129" "1.095" "1.144" "1.120" "1.147" "2.250" "48.1" "57.1" "51.9" "51.6" "54.3" "52.6" "55.0" "53.8" "55.1" "108.1" "" "" "" "" "" "" "" "" "" "" "42.6" "47.3" "45.3" "38.6" "45.2" "48.3" "46.5" "44.5" "50.6" "108.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3115652048582382832" "False" "High" "IsMasterProtein" "Q5D1E8" "Endoribonuclease ZC3H12A OS=Homo sapiens OX=9606 GN=ZC3H12A PE=1 SV=1" "0.001" "False" "4.392" "2" "1" "1" "1" "599" "65.7" "6.93" "3.25" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf11977, Pf18039, Pf18561" "80149" "ENSG00000163874" "ZC3H12A" "D3DPT0; hsa:80149; Q5D1E8; Q6I9Z1; Q9H5P1" "Regulation of CDH19 Expression and Function" "IL-18 signaling pathway" "2" "0" "1.054" "0.933" "0.965" "0.967" "0.893" "0.917" "0.727" "0.879" "2.801" "129.1" "136.2" "120.5" "124.7" "124.9" "115.3" "118.5" "93.9" "113.6" "361.7" "" "" "" "" "" "" "" "" "" "" "114.5" "112.8" "105.1" "93.2" "104.1" "105.9" "100.1" "77.6" "104.1" "361.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5238578015229203469" "False" "High" "IsMasterProtein" "Q96A54" "Adiponectin receptor protein 1 OS=Homo sapiens OX=9606 GN=ADIPOR1 PE=1 SV=1" "0.001" "False" "4.382" "5" "1" "1" "1" "375" "42.6" "7.02" "2.21" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf03006" "51094" "ENSG00000159346" "ADIPOR1" "B3KMB0; hsa:51094; Q53HS7; Q53YY6; Q96A54; Q9Y360" "AMPK inhibits chREBP transcriptional activation activity" "AMP-activated protein kinase signaling; Leptin and adiponectin; Nonalcoholic fatty liver disease" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2285465926165935505" "False" "High" "IsMasterProtein" "Q8WVN8" "Ubiquitin-conjugating enzyme E2 Q2 OS=Homo sapiens OX=9606 GN=UBE2Q2 PE=1 SV=1" "0.001" "False" "4.377" "4" "2" "2" "1" "375" "42.8" "4.96" "4.41" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179, Pf05773" "92912" "ENSG00000140367" "UBE2Q2" "B7Z3Q2; H3BRG2; hsa:92912; Q8N4G6; Q8WVN8; Q96J08" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5139072581549819915" "False" "High" "IsMasterProtein" "Q8IWV8" "E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens OX=9606 GN=UBR2 PE=1 SV=1" "0.001" "False" "4.376" "1" "2" "2" "2" "1755" "200.4" "6.24" "4.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "23304" "ENSG00000024048" "UBR2" "O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0; Q8IWV8" "Antigen processing: Ubiquitination & Proteasome degradation" "Male infertility; Primary ovarian insufficiency" "3" "0" "1.323" "1.054" "1.183" "1.106" "1.219" "0.896" "0.833" "0.955" "2.046" "123.7" "163.6" "130.4" "146.3" "136.7" "150.7" "110.8" "103.0" "118.1" "253.0" "" "" "" "" "" "" "" "" "" "" "109.7" "135.5" "113.7" "109.4" "114.0" "138.5" "93.6" "85.2" "108.3" "253.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1698124095596496194" "False" "High" "IsMasterProtein" "Q14147" "Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens OX=9606 GN=DHX34 PE=1 SV=2" "0.001" "False" "4.351" "1" "1" "1" "1" "1143" "128.0" "7.56" "1.71" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9704" "ENSG00000134815" "DHX34" "B4DMY8; hsa:9704; Q14147" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5856791832017367250" "False" "High" "IsMasterProtein" "Q09327" "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=MGAT3 PE=1 SV=3" "0.001" "False" "4.340" "3" "2" "2" "2" "533" "61.3" "8.28" "6.29" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf04724" "4248" "ENSG00000128268" "MGAT3" "A6NGD0; hsa:4248; Q09327; Q14CK5; Q6IC49; Q9UH32" "Reactions specific to the hybrid N-glycan synthesis pathway" "N-glycan biosynthesis" "2" "0" "0.602" "0.550" "0.628" "0.511" "0.646" "0.569" "0.532" "0.725" "0.700" "218.8" "131.7" "120.3" "137.4" "111.8" "141.4" "124.4" "116.4" "158.6" "153.1" "" "" "" "" "" "" "" "" "" "" "194.0" "109.1" "105.0" "102.7" "93.2" "129.9" "105.1" "96.2" "145.4" "153.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1474010075378452952" "False" "High" "IsMasterProtein" "P15924" "Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3" "0.001" "False" "4.339" "0" "1" "1" "1" "2871" "331.6" "6.81" "3.48" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00681, Pf17902, Pf18373, Pf21019" "1832" "ENSG00000096696" "DSP" "B2RTT2; D7RX09; hsa:1832; O75993; P15924; Q14189; Q9UHN4" "Formation of the cornified envelope; Neutrophil degranulation; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6628953901266874184" "False" "High" "IsMasterProtein" "Cont_P50448" "Factor XIIa inhibitor OS=Bos taurus OX=9913 PE=1 SV=1" "0.001" "True" "4.339" "2" "1" "1" "1" "468" "51.7" "6.67" "3.23" "1" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00079" "" "" "" "" "" "" "0" "0" "1.074" "1.098" "1.012" "1.038" "0.844" "0.967" "1.009" "0.863" "0.669" "186.2" "199.9" "204.5" "188.5" "193.2" "157.1" "180.0" "188.0" "160.7" "124.6" "" "" "" "" "" "" "" "" "" "" "165.1" "165.6" "178.5" "141.0" "161.1" "144.3" "152.2" "155.4" "147.4" "124.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5641519450922138293" "False" "High" "IsMasterProtein" "P15954" "Cytochrome c oxidase subunit 7C, mitochondrial OS=Homo sapiens OX=9606 GN=COX7C PE=1 SV=1" "0.001" "False" "4.329" "14" "1" "1" "1" "63" "7.2" "10.27" "4.35" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02935" "1350" "ENSG00000127184" "COX7C" "hsa:1350; P15954; Q6NR81" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "7" "0" "0.990" "0.944" "0.889" "0.903" "1.152" "0.868" "0.986" "1.011" "0.405" "143.3" "141.8" "135.3" "127.4" "129.5" "165.0" "124.4" "141.3" "144.8" "58.0" "" "" "" "" "" "" "" "" "" "" "127.1" "117.5" "118.0" "95.3" "107.9" "151.6" "105.1" "116.8" "132.8" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911938199932515837" "False" "High" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "0.001" "False" "4.327" "1" "1" "1" "1" "722" "78.9" "6.38" "3.61" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "" "3" "0" "0.738" "0.717" "0.760" "0.681" "0.569" "0.654" "0.474" "0.898" "4.395" "230.1" "169.8" "165.0" "174.9" "156.8" "131.1" "150.6" "109.0" "206.8" "1011.4" "" "" "" "" "" "" "" "" "" "" "204.1" "140.7" "143.9" "130.8" "130.8" "120.4" "127.3" "90.1" "189.6" "1011.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6748145975597498784" "False" "High" "IsMasterProtein" "O75920" "Small EDRK-rich factor 1 OS=Homo sapiens OX=9606 GN=SERF1B PE=1 SV=1" "0.001" "False" "4.325" "8" "1" "1" "1" "110" "12.3" "9.76" "3.84" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04419" "728492; 8293" "ENSG00000172058; ENSG00000205572; ENSG00000275581; ENSG00000277429; ENSG00000278839" "SERF1A; SERF1B" "B7ZKM2; hsa:728492; hsa:8293; O75919; O75920; Q52LK5" "" "" "0" "0" "1.040" "0.890" "1.003" "0.938" "0.959" "0.941" "0.863" "0.927" "0.546" "148.3" "154.3" "132.0" "148.8" "139.0" "142.1" "139.6" "128.0" "137.4" "81.0" "" "" "" "" "" "" "" "" "" "" "131.5" "127.8" "115.2" "111.3" "115.9" "130.6" "117.9" "105.8" "126.0" "81.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9197774965471602114" "False" "High" "IsMasterProtein" "O60942" "mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1" "0.001" "False" "4.317" "1" "1" "1" "1" "597" "68.5" "8.13" "3.47" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00782, Pf01331, Pf03919" "8732" "ENSG00000111880" "RNGTT" "E1P513; E1P514; hsa:8732; O43483; O60257; O60351; O60942; Q5TCW8; Q8WUM8" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "mRNA processing; Ciliary landscape" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6094458348163371601" "False" "High" "IsMasterProtein" "Q8NI32" "Ly6/PLAUR domain-containing protein 6B OS=Homo sapiens OX=9606 GN=LYPD6B PE=1 SV=1" "0.001" "False" "4.309" "7" "1" "1" "1" "183" "20.6" "7.78" "3.38" "1" "" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf16975" "130576" "ENSG00000150556" "LYPD6B" "D3DP90; hsa:130576; Q53TK0; Q7Z747; Q8IXK7; Q8NI32" "Post-translational modification: synthesis of GPI-anchored proteins" "" "1" "0" "0.910" "1.143" "0.945" "1.017" "0.911" "0.668" "0.609" "1.123" "0.600" "21.6" "19.6" "24.6" "20.4" "21.9" "19.6" "14.4" "13.1" "24.2" "12.9" "" "" "" "" "" "" "" "" "" "" "19.1" "16.3" "21.5" "15.2" "18.3" "18.0" "12.2" "10.9" "22.2" "12.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2682547924160316204" "False" "High" "IsMasterProtein" "Q8WVD5" "RING finger protein 141 OS=Homo sapiens OX=9606 GN=RNF141 PE=1 SV=1" "0.001" "False" "4.305" "4" "1" "1" "1" "230" "25.5" "5.20" "3.08" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes" "other molecular function" "Pf13639" "50862" "ENSG00000110315" "RNF141" "A8K149; hsa:50862; Q8WVD5; Q9NZB4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564518688305977023" "False" "High" "IsMasterProtein" "Q9H633" "Ribonuclease P protein subunit p21 OS=Homo sapiens OX=9606 GN=RPP21 PE=1 SV=1" "0.001" "False" "4.304" "10" "2" "3" "2" "154" "17.6" "9.45" "7.87" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04032" "79897" "ENSG00000239865; ENSG00000239927; ENSG00000241370; ENSG00000241779; ENSG00000241863; ENSG00000242726; ENSG00000243009" "RPP21" "A2AAZ8; B0S834; B0S835; hsa:79897; Q5JPL9; Q5JPM1; Q5STF8; Q5STF9; Q5STG2; Q5SU41; Q5SU42; Q86Y49; Q86Y50; Q86Y51; Q96F16; Q9H633" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8095866348413873216" "False" "High" "IsMasterProtein" "Q8WUB8" "PHD finger protein 10 OS=Homo sapiens OX=9606 GN=PHF10 PE=1 SV=3" "0.001" "False" "4.295" "2" "1" "1" "1" "498" "56.0" "6.62" "3.14" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628" "55274" "ENSG00000130024" "PHF10" "hsa:55274; Q2YDA3; Q53HG8; Q8WUB8; Q9BXD2; Q9NV26" "" "" "0" "0" "1.198" "0.864" "1.206" "1.057" "1.034" "1.088" "1.002" "0.947" "1.754" "118.3" "141.8" "102.2" "142.7" "125.1" "122.4" "128.7" "118.5" "112.0" "207.5" "" "" "" "" "" "" "" "" "" "" "104.9" "117.4" "89.2" "106.7" "104.3" "112.4" "108.8" "98.0" "102.8" "207.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1905410913598438347" "False" "High" "IsMasterProtein" "Q96FN9" "D-aminoacyl-tRNA deacylase 2 OS=Homo sapiens OX=9606 GN=DTD2 PE=1 SV=1" "0.001" "False" "4.280" "13" "2" "2" "2" "168" "18.6" "7.84" "5.27" "2" "RNA metabolism OR transcription" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "112487" "ENSG00000129480" "DTD2" "D3DS87; hsa:112487; Q96FN9" "" "" "0" "0" "0.881" "0.882" "1.280" "0.972" "0.796" "1.029" "0.999" "0.885" "0.869" "36.2" "31.9" "31.9" "46.3" "35.2" "28.8" "37.2" "36.1" "32.0" "31.5" "" "" "" "" "" "" "" "" "" "" "32.1" "26.4" "27.8" "34.6" "29.3" "26.5" "31.5" "29.9" "29.4" "31.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-359770206824869393" "False" "High" "IsMasterProtein" "P50747" "Biotin--protein ligase OS=Homo sapiens OX=9606 GN=HLCS PE=1 SV=1" "0.001" "False" "4.278" "2" "2" "2" "2" "726" "80.7" "5.62" "5.69" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02237, Pf03099" "3141" "ENSG00000159267" "HLCS" "B2RAH1; D3DSG6; hsa:3141; P50747; Q99451" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "" "2" "0" "0.992" "0.949" "0.951" "0.949" "0.869" "1.037" "0.985" "0.900" "2.129" "102.0" "101.2" "96.8" "97.0" "96.8" "88.6" "105.8" "100.4" "91.8" "217.1" "" "" "" "" "" "" "" "" "" "" "90.5" "83.9" "84.5" "72.6" "80.7" "81.4" "89.4" "83.0" "84.2" "217.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502282286759796404" "False" "High" "IsMasterProtein" "O00411" "DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2" "0.001" "False" "4.277" "1" "1" "1" "1" "1230" "138.5" "8.98" "3.28" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00940, Pf14700" "5442" "ENSG00000099821" "POLRMT" "hsa:5442; O00411; O60370" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Mitochondrial gene expression" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5802348527153736499" "False" "High" "IsMasterProtein" "Q0VDD7" "Break repair meiotic recombinase recruitment factor 1 OS=Homo sapiens OX=9606 GN=BRME1 PE=1 SV=2" "0.001" "False" "4.266" "2" "1" "1" "1" "668" "69.5" "4.83" "3.29" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "" "Pf15710" "79173" "ENSG00000132016; ENSG00000288152" "BRME1" "hsa:79173; Q0VDD7; Q13411; Q8N825; Q96D63; Q9BU49" "" "" "0" "0" "1.129" "1.117" "1.209" "1.146" "0.624" "0.917" "0.936" "1.169" "0.414" "33.0" "37.2" "36.8" "39.8" "37.8" "20.6" "30.2" "30.8" "38.5" "13.6" "" "" "" "" "" "" "" "" "" "" "29.2" "30.8" "32.1" "29.8" "31.5" "18.9" "25.5" "25.5" "35.3" "13.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625580668015925346" "False" "High" "IsMasterProtein" "Q9HCK8" "Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5" "0.001" "False" "4.264" "0" "1" "1" "1" "2581" "290.3" "6.47" "2.82" "1" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "57680" "ENSG00000100888" "CHD8" "hsa:57680; Q4G0D8; Q68DQ0; Q6DKH9; Q6P440; Q6ZNL7; Q8N3Z9; Q8NCY4; Q8TBR9; Q96F26; Q9HCK8" "Deactivation of the beta-catenin transactivating complex" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2036393970743301611" "False" "High" "IsMasterProtein" "Q8N9M5" "Transmembrane protein 102 OS=Homo sapiens OX=9606 GN=TMEM102 PE=1 SV=1" "0.001" "False" "4.263" "2" "1" "1" "1" "508" "54.1" "5.91" "3.40" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "" "" "284114" "ENSG00000181284; ENSG00000284228" "TMEM102" "D3DTP8; hsa:284114; Q8N9M5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585817169106109779" "False" "High" "IsMasterProtein" "Q9P2D1" "Chromodomain-helicase-DNA-binding protein 7 OS=Homo sapiens OX=9606 GN=CHD7 PE=1 SV=3" "0.001" "False" "4.261" "0" "1" "1" "1" "2997" "335.7" "6.34" "3.35" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "55636" "ENSG00000171316" "CHD7" "D0VBA5; E9PNZ2; hsa:55636; Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; Q9P2D1" "" "Kallmann syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3271098639454742173" "False" "High" "IsMasterProtein" "Q9H9B4" "Sideroflexin-1 OS=Homo sapiens OX=9606 GN=SFXN1 PE=1 SV=4" "0.001" "False" "4.253" "3" "1" "1" "1" "322" "35.6" "9.07" "4.12" "1" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf03820" "94081" "ENSG00000164466" "SFXN1" "B3KPW3; D3DQN2; hsa:94081; Q9H9B4; Q9HA53" "" "Metabolic Epileptic Disorders" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8783162572127248995" "False" "High" "IsMasterProtein" "Q9H4A5" "Golgi phosphoprotein 3-like OS=Homo sapiens OX=9606 GN=GOLPH3L PE=1 SV=1" "0.001" "False" "4.244" "5" "1" "1" "1" "285" "32.7" "5.83" "4.82" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf05719" "55204" "ENSG00000143457" "GOLPH3L" "B1AN09; B7Z6N3; hsa:55204; Q9H4A5; Q9NVK0" "" "" "0" "0" "1.030" "0.765" "1.111" "0.861" "0.758" "1.050" "0.562" "0.800" "5.824" "75.9" "78.3" "58.1" "84.4" "65.4" "57.5" "79.7" "42.7" "60.8" "442.3" "" "" "" "" "" "" "" "" "" "" "67.3" "64.8" "50.7" "63.1" "54.5" "52.9" "67.4" "35.3" "55.7" "442.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3835661040312072050" "False" "High" "IsMasterProtein" "Q9BUA3" "Spindlin interactor and repressor of chromatin-binding protein OS=Homo sapiens OX=9606 GN=SPINDOC PE=1 SV=3" "0.001" "False" "4.236" "5" "2" "2" "2" "381" "41.0" "5.01" "5.86" "2" "stress response;other biological processes" "nucleus;other cell component" "" "Pf18658" "144097" "ENSG00000168005" "SPINDOC" "hsa:144097; Q68CV7; Q6PHS2; Q96IH0; Q9BUA3" "" "" "0" "0" "0.989" "0.877" "1.023" "1.047" "0.912" "1.050" "0.963" "0.986" "0.808" "217.9" "215.5" "191.2" "222.8" "228.2" "198.6" "228.9" "210.0" "214.9" "176.1" "" "" "" "" "" "" "" "" "" "" "193.2" "178.5" "166.8" "166.7" "190.3" "182.5" "193.4" "173.5" "197.1" "176.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288572419513908439" "False" "High" "IsMasterProtein" "Q8WXG6" "MAP kinase-activating death domain protein OS=Homo sapiens OX=9606 GN=MADD PE=1 SV=2" "0.001" "False" "4.235" "2" "2" "2" "2" "1647" "183.2" "6.04" "2.55" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf02141, Pf03456" "8567" "ENSG00000110514" "MADD" "A8K8S7; B5MEE5; D3DQR4; hsa:8567; O15065; O15293; Q15732; Q15741; Q8IWD7; Q8WXG3; Q8WXG4; Q8WXG5; Q8WXG6; Q8WZ63" "" "Apoptosis modulation and signaling; Deregulation of Rab and Rab effector genes in bladder cancer; TNF-alpha signaling pathway" "3" "0" "1.345" "1.029" "1.203" "1.194" "1.116" "1.278" "0.869" "0.886" "1.560" "52.7" "70.9" "54.2" "63.4" "62.9" "58.8" "67.4" "45.8" "46.7" "82.2" "" "" "" "" "" "" "" "" "" "" "46.8" "58.7" "47.3" "47.4" "52.5" "54.0" "57.0" "37.9" "42.8" "82.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054599493317546199" "False" "High" "IsMasterProtein" "Q8TCC3" "Large ribosomal subunit protein uL30m OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1" "0.001" "False" "4.232" "6" "1" "1" "1" "161" "18.5" "9.99" "3.04" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00327" "51263" "ENSG00000185414" "MRPL30" "A6NIC6; D3DVI0; D3DVI3; hsa:51263; Q0D2Q7; Q6ZTP4; Q8TCC3; Q96Q69; Q9P0N0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.890" "0.892" "0.810" "0.793" "0.803" "0.948" "0.868" "0.909" "2.387" "124.6" "111.0" "111.2" "100.9" "98.8" "100.1" "118.2" "108.2" "113.3" "297.5" "" "" "" "" "" "" "" "" "" "" "110.5" "91.9" "97.1" "75.5" "82.4" "91.9" "99.9" "89.5" "103.9" "297.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8879076887959786971" "False" "High" "IsMasterProtein" "Q9P1Y6" "PHD and RING finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PHRF1 PE=1 SV=3" "0.001" "False" "4.225" "1" "1" "1" "1" "1649" "178.6" "8.95" "3.38" "1" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf00628, Pf13639" "57661" "ENSG00000070047; ENSG00000274780" "PHRF1" "A6H8W1; B7ZM64; B9EGP0; C9JS82; hsa:57661; Q6PJP2; Q8IVY2; Q8N2Y7; Q9BSM2; Q9P1Y6" "" "" "0" "0" "1.066" "0.959" "1.138" "1.112" "1.074" "0.984" "0.959" "0.962" "1.372" "203.8" "217.2" "195.6" "232.0" "226.6" "218.9" "200.5" "195.5" "196.0" "279.8" "" "" "" "" "" "" "" "" "" "" "180.7" "180.0" "170.6" "173.5" "188.9" "201.1" "169.5" "161.6" "179.8" "279.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "High" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.001" "False" "4.220" "5" "2" "2" "2" "315" "34.6" "4.64" "5.71" "2" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "1.130" "0.899" "1.068" "1.001" "0.887" "0.851" "0.693" "0.911" "8.321" "91.2" "103.1" "82.0" "97.4" "91.3" "80.9" "77.6" "63.2" "83.1" "758.9" "" "" "" "" "" "" "" "" "" "" "80.9" "85.4" "71.5" "72.8" "76.1" "74.3" "65.6" "52.2" "76.2" "758.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4426217636715391666" "False" "High" "IsMasterProtein" "Q9H9F9" "Actin-related protein 5 OS=Homo sapiens OX=9606 GN=ACTR5 PE=1 SV=2" "0.001" "False" "4.213" "2" "1" "1" "1" "607" "68.3" "5.27" "3.63" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00022" "79913" "ENSG00000101442" "ACTR5" "hsa:79913; Q86WF7; Q8IUY5; Q8N724; Q9BRN0; Q9BVB7; Q9H9F9" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175071030841702515" "False" "High" "IsMasterProtein" "Q96N06" "Spermatogenesis-associated protein 33 OS=Homo sapiens OX=9606 GN=SPATA33 PE=1 SV=1" "0.001" "False" "4.210" "7" "1" "1" "1" "139" "15.5" "9.22" "3.18" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf15382" "124045" "ENSG00000167523" "SPATA33" "A8WFL2; B4DZN8; hsa:124045; Q96N06" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2038864956739730739" "False" "High" "IsMasterProtein" "Q96S21" "Ras-related protein Rab-40C OS=Homo sapiens OX=9606 GN=RAB40C PE=1 SV=1" "0.001" "False" "4.204" "7" "2" "2" "2" "281" "31.3" "9.19" "6.44" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071, Pf07525" "57799" "ENSG00000197562" "RAB40C" "A2IDE2; D3DU54; hsa:57799; O60795; Q4TT41; Q5PXE8; Q6PIU5; Q96S21" "RAB geranylgeranylation" "" "1" "0" "0.835" "0.780" "0.947" "0.816" "0.942" "0.810" "0.805" "0.874" "0.665" "111.9" "93.4" "87.2" "105.9" "91.3" "105.4" "90.7" "90.1" "97.8" "74.4" "" "" "" "" "" "" "" "" "" "" "99.2" "77.4" "76.1" "79.2" "76.1" "96.8" "76.6" "74.4" "89.7" "74.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298882931648225908" "False" "High" "IsMasterProtein" "Q9UGJ1" "Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1" "0.001" "False" "4.204" "2" "1" "1" "1" "667" "76.0" "6.65" "4.31" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cytoplasmic organelle" "cytoskeletal activity" "Pf04130, Pf17681" "27229" "ENSG00000137822" "TUBGCP4" "B3KNK6; hsa:27229; Q969X3; Q9NVF0; Q9UGJ1" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "0.869" "0.825" "1.204" "0.911" "0.885" "1.017" "0.814" "0.829" "1.087" "288.6" "250.9" "238.2" "347.4" "262.8" "255.4" "293.4" "235.0" "239.1" "313.7" "" "" "" "" "" "" "" "" "" "" "255.9" "207.8" "207.8" "259.8" "219.1" "234.7" "248.0" "194.2" "219.3" "313.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4254147789153280630" "False" "High" "IsMasterProtein" "Q9BZ68" "Putative FERM domain-containing protein FRMD8P1 OS=Homo sapiens OX=9606 GN=FRMD8P1 PE=5 SV=2" "0.001" "False" "4.200" "2" "1" "1" "1" "369" "41.1" "5.82" "3.59" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton" "" "Pf00373" "" "" "FRMD8P1" "A1A4X4; Q9BZ68" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9106014466644302785" "False" "High" "IsMasterProtein" "Q9Y5Q8" "General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2" "0.001" "False" "4.195" "2" "1" "1" "1" "519" "59.5" "6.90" "3.78" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09734, Pf17682" "9328" "ENSG00000148308" "GTF3C5" "A6NI44; A6NJB9; hsa:9328; Q5T7U2; Q5T7U3; Q8N2U7; Q8N857; Q96GD9; Q9H4P2; Q9Y5Q8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "0.940" "0.889" "1.017" "0.653" "0.787" "0.828" "0.529" "0.884" "7.049" "89.8" "84.4" "79.9" "91.4" "58.7" "70.7" "74.4" "47.5" "79.4" "633.3" "" "" "" "" "" "" "" "" "" "" "79.7" "69.9" "69.7" "68.3" "48.9" "64.9" "62.9" "39.3" "72.8" "633.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5043724223572356605" "False" "High" "IsMasterProtein" "A6H8Y1" "Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3" "0.001" "False" "4.181" "0" "1" "1" "1" "2624" "293.7" "5.11" "2.92" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15963" "55814" "ENSG00000145734; ENSG00000273873" "BDP1" "A6H8Y1; hsa:55814; Q68DS6; Q68DY5; Q6MZL9; Q6PIM7; Q86W98; Q96LR8; Q9C0H4; Q9H197; Q9H1A1; Q9HAW1; Q9HAW2; Q9HCY0; Q9ULH9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "" "4" "0" "1.027" "0.928" "1.053" "0.892" "0.948" "0.841" "0.900" "0.811" "0.672" "72.3" "74.3" "67.1" "76.1" "64.5" "68.5" "60.8" "65.1" "58.7" "48.6" "" "" "" "" "" "" "" "" "" "" "64.1" "61.5" "58.5" "56.9" "53.8" "62.9" "51.4" "53.8" "53.8" "48.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765720071674471585" "False" "High" "IsMasterProtein" "Q15633" "RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3" "0.001" "False" "4.177" "4" "1" "1" "1" "366" "39.0" "6.54" "3.50" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "6895" "ENSG00000139546" "TARBP2" "hsa:6895; Q12878; Q15633; Q8WY32; Q8WY33; Q9BRY2" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "6" "0" "1.067" "0.937" "1.035" "0.931" "0.974" "0.983" "0.869" "0.871" "1.017" "111.8" "119.3" "104.8" "115.7" "104.0" "108.9" "109.8" "97.1" "97.4" "113.7" "" "" "" "" "" "" "" "" "" "" "99.1" "98.8" "91.4" "86.5" "86.7" "100.0" "92.8" "80.3" "89.3" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7841713393868884800" "False" "High" "IsMasterProtein" "Q9BSL1" "Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBAC1 PE=1 SV=1" "0.001" "False" "4.170" "3" "1" "1" "1" "405" "45.3" "4.92" "3.37" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00627" "10422" "ENSG00000130560" "UBAC1" "hsa:10422; O75500; Q9BSL1; Q9UMW7" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4681689282303476282" "False" "High" "IsMasterProtein" "Q9BX95" "Sphingosine-1-phosphate phosphatase 1 OS=Homo sapiens OX=9606 GN=SGPP1 PE=1 SV=2" "0.001" "False" "4.151" "2" "1" "2" "1" "441" "49.1" "8.82" "3.13" "1" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01569" "81537" "ENSG00000126821; ENSG00000285281" "SGPP1" "B2RAH0; hsa:81537; Q9BX95; Q9H189" "Sphingolipid catabolism" "Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases" "4" "0" "1.064" "0.990" "0.984" "0.947" "1.016" "0.959" "0.996" "1.060" "0.417" "107.5" "114.4" "106.5" "105.9" "101.8" "109.3" "103.1" "107.1" "114.0" "44.8" "" "" "" "" "" "" "" "" "" "" "95.4" "94.8" "92.9" "79.2" "84.9" "100.4" "87.2" "88.5" "104.6" "44.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785970027012849018" "False" "High" "IsMasterProtein" "A0JLT2" "Mediator of RNA polymerase II transcription subunit 19 OS=Homo sapiens OX=9606 GN=MED19 PE=1 SV=2" "0.001" "False" "4.148" "5" "1" "1" "1" "244" "26.3" "9.82" "4.17" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10278" "219541" "ENSG00000156603" "MED19" "A0JLT2; hsa:219541; Q8IV02; Q8IZD1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714801153834532541" "False" "High" "IsMasterProtein" "O14733" "Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2" "0.001" "False" "4.139" "4" "1" "1" "1" "419" "47.5" "9.16" "4.85" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5609" "ENSG00000076984" "MAP2K7" "B2R9S5; D6W659; hsa:5609; O14648; O14733; O14816; O60452; O60453; Q1PG43; Q8IY10" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105590479105363220" "False" "High" "IsMasterProtein" "O60870" "DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2" "0.001" "False" "4.132" "2" "1" "1" "1" "393" "45.3" "8.95" "4.17" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10357, Pf18131" "22944" "ENSG00000151657" "KIN" "B4DX32; hsa:22944; O60870" "Protein methylation" "" "1" "0" "0.904" "0.969" "0.966" "0.961" "0.942" "0.936" "0.510" "0.973" "7.426" "132.9" "120.1" "128.7" "128.3" "127.7" "125.2" "124.4" "67.8" "129.3" "986.7" "" "" "" "" "" "" "" "" "" "" "117.8" "99.5" "112.3" "96.0" "106.5" "115.0" "105.1" "56.0" "118.6" "986.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3081383647301722280" "False" "High" "IsMasterProtein" "Q16540" "Large ribosomal subunit protein uL23m OS=Homo sapiens OX=9606 GN=MRPL23 PE=1 SV=1" "0.001" "False" "4.127" "13" "1" "1" "1" "153" "17.8" "9.69" "2.76" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00276" "6150" "ENSG00000214026; ENSG00000288141" "MRPL23" "A8MT29; hsa:6150; Q16540; Q96Q71" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4190434278171363026" "False" "High" "IsMasterProtein" "Q92547" "DNA topoisomerase 2-binding protein 1 OS=Homo sapiens OX=9606 GN=TOPBP1 PE=1 SV=3" "0.001" "False" "4.124" "1" "1" "1" "1" "1522" "170.6" "6.96" "2.09" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00533" "11073" "ENSG00000163781" "TOPBP1" "B7Z7W8; hsa:11073; Q7LGC1; Q92547; Q9UEB9" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "ATR signaling" "7" "0" "1.115" "0.811" "1.451" "1.052" "1.140" "1.177" "1.150" "1.040" "2.954" "24.9" "27.8" "20.2" "36.2" "26.2" "28.4" "29.3" "28.7" "25.9" "73.6" "" "" "" "" "" "" "" "" "" "" "22.1" "23.0" "17.6" "27.0" "21.9" "26.1" "24.8" "23.7" "23.8" "73.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "62190601314665841" "False" "High" "IsMasterProtein" "Q14207" "Protein NPAT OS=Homo sapiens OX=9606 GN=NPAT PE=1 SV=3" "0.001" "False" "4.120" "1" "1" "1" "1" "1427" "154.2" "5.88" "3.40" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15712" "4863" "ENSG00000149308" "NPAT" "A8K1V5; A8K6M2; hsa:4863; Q13632; Q14207; Q14967; Q16580; Q86W55; Q8IWE9" "" "Retinoblastoma gene in cancer" "1" "0" "0.675" "0.688" "0.738" "0.661" "0.814" "0.755" "0.604" "0.882" "1.006" "82.3" "55.6" "56.6" "60.8" "54.5" "67.0" "62.1" "49.7" "72.6" "82.8" "" "" "" "" "" "" "" "" "" "" "73.0" "46.1" "49.4" "45.5" "45.4" "61.6" "52.5" "41.1" "66.6" "82.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750052983451588697" "False" "High" "IsMasterProtein" "O43166" "Signal-induced proliferation-associated 1-like protein 1 OS=Homo sapiens OX=9606 GN=SIPA1L1 PE=1 SV=4" "0.001" "False" "4.117" "1" "1" "1" "1" "1804" "199.9" "8.19" "2.77" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "26037" "ENSG00000197555" "SIPA1L1" "hsa:26037; J3KP19; O43166; O95321; Q9UDU4; Q9UNU4" "Neurexins and neuroligins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3369989001081277177" "False" "High" "IsMasterProtein" "Q96CN9" "GRIP and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GCC1 PE=1 SV=1" "0.001" "False" "4.115" "1" "1" "1" "1" "775" "87.8" "5.45" "3.61" "1" "" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01465" "79571" "ENSG00000179562" "GCC1" "hsa:79571; Q96CN9; Q9H6N7" "Retrograde transport at the Trans-Golgi-Network" "Nuclear receptors meta-pathway" "2" "0" "0.933" "0.888" "0.895" "0.882" "0.773" "0.981" "0.671" "1.108" "8.060" "23.6" "22.1" "21.0" "21.2" "20.9" "18.3" "23.2" "15.9" "26.2" "190.6" "" "" "" "" "" "" "" "" "" "" "21.0" "18.3" "18.3" "15.8" "17.4" "16.8" "19.6" "13.1" "24.0" "190.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.001" "False" "4.112" "9" "2" "2" "2" "175" "20.0" "10.11" "5.91" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.041" "0.850" "0.694" "0.765" "0.815" "0.909" "0.919" "1.039" "2.893" "75.9" "79.0" "64.5" "52.6" "58.1" "61.9" "69.0" "69.8" "78.8" "219.5" "" "" "" "" "" "" "" "" "" "" "67.3" "65.4" "56.3" "39.4" "48.4" "56.8" "58.3" "57.7" "72.3" "219.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8450189262583768708" "False" "High" "IsMasterProtein" "Q96NT0" "Coiled-coil domain-containing protein 115 OS=Homo sapiens OX=9606 GN=CCDC115 PE=1 SV=1" "0.001" "False" "4.105" "7" "1" "1" "1" "180" "19.7" "6.95" "3.79" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf21730" "84317" "ENSG00000136710" "CCDC115" "B4DJ47; hsa:84317; Q96NT0; Q9BR88" "RHOA GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7568231581715943755" "False" "High" "IsMasterProtein" "Q7Z333" "Probable helicase senataxin OS=Homo sapiens OX=9606 GN=SETX PE=1 SV=4" "0.001" "False" "4.102" "0" "1" "1" "1" "2677" "302.7" "7.17" "3.93" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087" "23064" "ENSG00000107290" "SETX" "A2A396; B2RPB2; B5ME16; C9JQ10; hsa:23064; O75120; Q3KQX4; Q5JUJ1; Q68DW5; Q6AZD7; Q7Z333; Q7Z3J6; Q8WX33; Q9H9D1; Q9NVP9" "" "Interactome of polycomb repressive complex 2 (PRC2)" "1" "0" "0.951" "0.979" "0.956" "0.978" "1.018" "0.909" "0.880" "0.889" "2.436" "206.9" "196.8" "202.5" "197.9" "202.3" "210.6" "188.2" "182.1" "183.9" "504.1" "" "" "" "" "" "" "" "" "" "" "183.5" "163.0" "176.7" "148.0" "168.7" "193.5" "159.0" "150.5" "168.7" "504.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4732323992224053242" "False" "High" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "0.001" "False" "4.100" "0" "2" "3" "2" "5596" "632.4" "5.68" "4.27" "2" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867, Pf21108" "23195" "ENSG00000112159" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "0.892" "0.895" "1.116" "0.907" "0.908" "0.885" "0.601" "1.053" "3.883" "41.6" "37.1" "37.2" "46.4" "37.7" "37.8" "36.8" "25.0" "43.8" "161.6" "" "" "" "" "" "" "" "" "" "" "36.9" "30.7" "32.5" "34.7" "31.5" "34.7" "31.1" "20.7" "40.2" "161.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2264903312611257722" "False" "High" "IsMasterProtein" "Q05469" "Hormone-sensitive lipase OS=Homo sapiens OX=9606 GN=LIPE PE=1 SV=4" "0.001" "False" "4.091" "1" "1" "1" "1" "1076" "116.5" "6.70" "2.68" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf06350, Pf07859" "3991" "ENSG00000079435" "LIPE" "hsa:3991; Q05469; Q3LRT2; Q6NSL7" "Triglyceride catabolism" "AMP-activated protein kinase signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy" "11" "0" "0.973" "1.041" "0.734" "0.678" "0.622" "0.674" "0.700" "1.207" "3.250" "27.7" "27.0" "28.9" "20.3" "18.8" "17.2" "18.7" "19.4" "33.5" "90.1" "" "" "" "" "" "" "" "" "" "" "24.6" "22.4" "25.2" "15.2" "15.7" "15.8" "15.8" "16.1" "30.7" "90.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "High" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.001" "False" "4.075" "11" "2" "2" "2" "142" "17.0" "6.18" "6.37" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "18" "0" "0.857" "0.947" "0.981" "0.981" "0.970" "0.878" "1.046" "0.842" "1.104" "141.5" "121.3" "134.1" "138.8" "138.9" "137.3" "124.3" "148.1" "119.1" "156.3" "" "" "" "" "" "" "" "" "" "" "125.5" "100.4" "117.0" "103.8" "115.8" "126.2" "105.1" "122.4" "109.3" "156.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8843415988459270294" "False" "High" "IsMasterProtein" "Q7Z2W9" "Large ribosomal subunit protein bL21m OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "0.001" "False" "4.075" "8" "2" "2" "2" "205" "22.8" "9.89" "5.52" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7525494529212049263" "False" "High" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0.001" "False" "4.074" "1" "3" "3" "3" "2961" "330.9" "5.95" "5.94" "3" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "1.015" "0.896" "1.260" "1.004" "0.906" "0.960" "1.126" "0.809" "1.324" "240.0" "243.6" "215.0" "302.6" "241.0" "217.6" "230.4" "270.2" "194.3" "317.8" "" "" "" "" "" "" "" "" "" "" "212.9" "201.8" "187.6" "226.3" "201.0" "199.9" "194.7" "223.4" "178.2" "317.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786951349264090061" "False" "High" "IsMasterProtein" "Q9P2I0" "Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2" "0.001" "False" "4.068" "1" "1" "1" "1" "782" "88.4" "5.11" "4.10" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07521, Pf10996, Pf13299, Pf16661" "53981" "ENSG00000165934" "CPSF2" "B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "0.993" "1.098" "1.086" "1.007" "1.003" "1.155" "1.020" "1.057" "3.524" "256.8" "255.0" "281.9" "279.0" "258.5" "257.7" "296.7" "261.9" "271.4" "905.1" "" "" "" "" "" "" "" "" "" "" "227.7" "211.2" "246.0" "208.6" "215.6" "236.7" "250.8" "216.5" "248.9" "905.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213215215106064220" "False" "High" "IsMasterProtein" "Q8WZ82" "Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1" "0.001" "False" "4.064" "6" "1" "1" "1" "227" "24.4" "6.89" "2.62" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf03959" "124641" "ENSG00000262664" "OVCA2" "hsa:124641; Q86XN3; Q8IW87; Q8WZ82; Q9UCX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3098042065705187363" "False" "High" "IsMasterProtein" "Q6IBW4" "Condensin-2 complex subunit H2 OS=Homo sapiens OX=9606 GN=NCAPH2 PE=1 SV=1" "0.001" "False" "4.054" "1" "1" "1" "1" "605" "68.2" "4.74" "3.67" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06278, Pf16858, Pf16869" "29781" "ENSG00000025770" "NCAPH2" "B7WPH1; hsa:29781; O43788; Q13391; Q6IBW4; Q96C14; Q96GJ0; Q9BQ71; Q9BUT3; Q9BVD1" "Condensation of Prophase Chromosomes" "IL-18 signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5489281537849050427" "False" "High" "IsMasterProtein" "Q9UEU0" "Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens OX=9606 GN=VTI1B PE=1 SV=3" "0.001" "False" "4.051" "4" "1" "1" "1" "232" "26.7" "9.04" "3.69" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "10490" "ENSG00000100568" "VTI1B" "hsa:10490; O43547; Q96J28; Q9UEU0" "Platelet degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8813199514956100081" "False" "High" "IsMasterProtein" "O94822" "E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6" "0.001" "False" "4.032" "1" "1" "1" "1" "1766" "200.4" "6.25" "2.52" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "" "26046" "ENSG00000198862; ENSG00000291534" "LTN1" "A6NL41; A7E2D0; B2RTS0; C9J7U3; J3KPL4; O94822; Q05C47; Q9H8M4; Q9NUY5; Q9P0E9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.893" "0.967" "0.939" "0.794" "0.998" "0.907" "0.414" "1.047" "7.999" "38.7" "34.5" "37.4" "36.4" "30.7" "38.6" "35.1" "16.0" "40.5" "309.6" "" "" "" "" "" "" "" "" "" "" "34.3" "28.6" "32.7" "27.2" "25.6" "35.5" "29.7" "13.2" "37.1" "309.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8564696200648567911" "False" "High" "IsMasterProtein" "O60930" "Ribonuclease H1 OS=Homo sapiens OX=9606 GN=RNASEH1 PE=1 SV=2" "0.001" "False" "4.028" "7" "1" "1" "1" "286" "32.0" "9.16" "3.50" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00075, Pf01693" "246243" "ENSG00000171865" "RNASEH1" "B3KQU4; hsa:246243; O60523; O60857; O60930; Q57Z93; Q5U0C1; Q6FHD4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3039666916282587145" "False" "High" "IsMasterProtein" "Q562E7" "WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2" "0.001" "False" "4.028" "1" "1" "1" "1" "1941" "211.6" "5.58" "3.32" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00400, Pf02138" "124997" "ENSG00000167716; ENSG00000276021" "WDR81" "B3KW16; B3KXU1; B7Z579; E9PHG7; hsa:124997; Q24JP6; Q562E7; Q8N277; Q8N3F3; Q8TEL1" "CDC42 GTPase cycle" "" "1" "0" "0.803" "1.010" "0.902" "1.176" "0.918" "1.056" "1.139" "0.925" "4.408" "23.0" "18.5" "23.2" "20.8" "27.1" "21.1" "24.3" "26.2" "21.3" "101.4" "" "" "" "" "" "" "" "" "" "" "20.4" "15.3" "20.3" "15.5" "22.6" "19.4" "20.5" "21.7" "19.5" "101.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8116747825737560157" "False" "High" "IsMasterProtein" "O15235" "Small ribosomal subunit protein uS12m OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" "0.001" "False" "4.020" "14" "2" "2" "2" "138" "15.2" "10.29" "4.88" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00164" "6183" "ENSG00000128626; ENSG00000283018" "MRPS12" "hsa:6183; O15235; Q53X98" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494734003636031426" "False" "High" "IsMasterProtein" "Q8N2Z9" "Centromere protein S OS=Homo sapiens OX=9606 GN=CENPS PE=1 SV=1" "0.001" "False" "4.017" "9" "1" "1" "1" "138" "15.9" "6.05" "2.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15630" "100526739; 378708" "ENSG00000175279" "CENPS" "hsa:100526739; hsa:378708; Q8N2Z9; Q8NFE5; Q8NFG5" "Fanconi Anemia Pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "DNA repair pathways, full network" "10" "0" "1.087" "0.935" "0.900" "1.084" "1.082" "1.045" "0.861" "1.073" "1.065" "52.4" "57.0" "49.0" "47.2" "56.9" "56.7" "54.8" "45.2" "56.3" "55.9" "" "" "" "" "" "" "" "" "" "" "46.5" "47.2" "42.8" "35.3" "47.4" "52.1" "46.3" "37.3" "51.6" "55.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7987145187797725947" "False" "High" "IsMasterProtein" "Q9H6R0" "ATP-dependent RNA helicase DHX33 OS=Homo sapiens OX=9606 GN=DHX33 PE=1 SV=2" "0.001" "False" "4.016" "2" "2" "2" "2" "707" "78.8" "8.91" "5.31" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "56919" "ENSG00000005100" "DHX33" "B4DHF9; hsa:56919; Q4G149; Q5CZ73; Q9H5M9; Q9H6R0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015349167503174310" "False" "High" "IsMasterProtein" "Q8NCC3" "Lysosomal phospholipase A and acyltransferase OS=Homo sapiens OX=9606 GN=PLA2G15 PE=1 SV=2" "0.001" "False" "4.014" "3" "1" "1" "1" "412" "46.6" "6.73" "3.03" "1" "other metabolic processes" "non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02450" "23659" "ENSG00000103066" "PLA2G15" "B3KMF3; B4DUD1; hsa:23659; Q53GZ1; Q8NCC3; Q9NPQ6; Q9UG04; Q9Y2B3" "Hydrolysis of LPC" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8510167409158157300" "False" "High" "IsMasterProtein" "Q8TB05" "UBA-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBALD1 PE=1 SV=1" "0.001" "False" "4.012" "5" "1" "1" "1" "177" "18.9" "6.64" "3.30" "1" "" "" "" "Pf14555" "124402" "ENSG00000153443" "UBALD1" "hsa:124402; Q71MF6; Q8TB05" "" "" "0" "0" "0.893" "0.859" "0.871" "1.052" "0.892" "0.753" "0.820" "0.918" "0.838" "82.9" "74.0" "71.2" "72.2" "87.2" "73.9" "62.4" "67.9" "76.1" "69.5" "" "" "" "" "" "" "" "" "" "" "73.5" "61.3" "62.1" "54.0" "72.7" "67.9" "52.7" "56.1" "69.8" "69.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4045203445570515749" "False" "High" "IsMasterProtein" "Q9BQ49" "Small integral membrane protein 7 OS=Homo sapiens OX=9606 GN=SMIM7 PE=1 SV=2" "0.001" "False" "4.010" "13" "1" "1" "1" "75" "8.6" "8.18" "3.94" "1" "" "other membranes" "" "" "79086" "ENSG00000214046" "SMIM7" "A8MX44; hsa:79086; Q9BQ49" "" "" "0" "0" "1.088" "0.932" "1.275" "0.970" "0.875" "0.826" "0.835" "0.766" "0.804" "213.2" "232.0" "198.7" "271.8" "206.7" "186.6" "176.0" "178.1" "163.2" "171.4" "" "" "" "" "" "" "" "" "" "" "189.0" "192.2" "173.3" "203.2" "172.3" "171.4" "148.7" "147.2" "149.7" "171.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340038493485661404" "False" "High" "IsMasterProtein" "O75665" "Centriole and centriolar satellite protein OFD1 OS=Homo sapiens OX=9606 GN=OFD1 PE=1 SV=1" "0.001" "False" "4.006" "1" "1" "1" "1" "1012" "116.6" "6.10" "4.23" "1" "cell organization and biogenesis;transport;developmental processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf16045" "8481" "ENSG00000046651" "OFD1" "B9ZVU5; hsa:8481; O75665; O75666; Q4VAK4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "300613952239317335" "False" "High" "IsMasterProtein" "O43766" "Lipoyl synthase, mitochondrial OS=Homo sapiens OX=9606 GN=LIAS PE=1 SV=3" "0.001" "False" "4.003" "3" "1" "1" "1" "372" "41.9" "8.59" "3.96" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion" "other molecular function" "Pf04055, Pf16881" "11019" "ENSG00000121897" "LIAS" "A8K873; C9JCF6; hsa:11019; O43766; Q8IV62" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "1.263" "1.011" "1.239" "1.064" "1.094" "1.043" "0.934" "0.993" "0.698" "79.9" "100.9" "80.7" "99.0" "85.0" "87.4" "83.3" "74.6" "79.3" "55.7" "" "" "" "" "" "" "" "" "" "" "70.8" "83.5" "70.5" "74.0" "70.9" "80.3" "70.4" "61.7" "72.7" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6633955161659000485" "False" "High" "IsMasterProtein" "O14662" "Syntaxin-16 OS=Homo sapiens OX=9606 GN=STX16 PE=1 SV=3" "0.001" "False" "4.000" "3" "1" "1" "1" "325" "37.0" "6.11" "3.23" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00804, Pf05739" "8675" "ENSG00000124222" "STX16" "A6NK32; A6NN69; A8MPP0; B7ZBN1; B7ZBN2; B7ZBN3; E1P5M0; E1P607; hsa:8675; O14661; O14662; O14663; O60517; Q5W084; Q5W086; Q5W087; Q5XKI6; Q6GMS8; Q9H0Z0; Q9H1T7; Q9H1T8; Q9UIX5" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "Ectoderm differentiation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "743722838785437812" "False" "High" "IsMasterProtein" "Q12846" "Syntaxin-4 OS=Homo sapiens OX=9606 GN=STX4 PE=1 SV=2" "0.001" "False" "3.997" "8" "2" "2" "2" "297" "34.2" "6.28" "4.41" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00804, Pf05739" "6810" "ENSG00000103496" "STX4" "A8MXY0; hsa:6810; Q12846; Q15525; Q6FHE8" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; ER-Phagosome pathway; trans-Golgi Network Vesicle Budding; Disinhibition of SNARE formation; Other interleukin signaling" "Insulin signaling; Vasopressin-regulated water reabsorption" "7" "0" "0.985" "0.812" "1.049" "0.922" "0.807" "0.963" "0.798" "0.862" "0.911" "283.3" "279.0" "230.1" "297.2" "261.1" "228.6" "272.7" "226.1" "244.3" "258.1" "" "" "" "" "" "" "" "" "" "" "251.2" "231.1" "200.8" "222.3" "217.7" "210.0" "230.5" "186.9" "224.0" "258.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446156853799225344" "False" "High" "IsMasterProtein" "Q9C0D2" "Centrosomal protein of 295 kDa OS=Homo sapiens OX=9606 GN=CEP295 PE=1 SV=4" "0.001" "False" "3.995" "0" "2" "5" "1" "2601" "295.0" "6.00" "11.38" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf15309" "85459" "ENSG00000166004" "CEP295" "C9J5H9; C9JQY8; hsa:85459; Q8N7L4; Q8N919; Q8N9B0; Q96LT8; Q9C0D2" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1988329424413395185" "False" "High" "IsMasterProtein" "Q8WVK7" "Spindle and kinetochore-associated protein 2 OS=Homo sapiens OX=9606 GN=SKA2 PE=1 SV=1" "0.001" "False" "3.981" "8" "1" "1" "1" "121" "14.2" "7.33" "3.54" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf16740" "348235" "ENSG00000182628" "SKA2" "A6NIL3; B3KPL3; E9PCB8; hsa:348235; Q8WVK7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6229866583710047273" "False" "High" "IsMasterProtein" "Q96C23" "Galactose mutarotase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1" "0.001" "False" "3.980" "3" "1" "1" "1" "342" "37.7" "6.65" "3.82" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf01263" "130589" "ENSG00000143891" "GALM" "hsa:130589; Q53RY1; Q8NIA2; Q96C23; V9HWA8" "" "" "0" "0" "0.991" "0.812" "0.916" "0.752" "1.051" "0.713" "0.851" "0.930" "1.160" "63.0" "62.4" "51.2" "57.7" "47.3" "66.2" "44.9" "53.6" "58.6" "73.1" "" "" "" "" "" "" "" "" "" "" "55.9" "51.7" "44.6" "43.2" "39.5" "60.8" "37.9" "44.3" "53.7" "73.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8994364974169992098" "False" "High" "IsMasterProtein" "Q6PIJ6" "F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3" "0.001" "False" "3.978" "1" "1" "1" "1" "1188" "133.9" "6.33" "2.81" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00646" "81545" "ENSG00000145868" "FBXO38" "hsa:81545; Q6PIJ6; Q6PK72; Q7Z2U0; Q86VN3; Q9BXY6; Q9H837; Q9HC40" "" "" "0" "0" "1.215" "1.673" "1.219" "1.252" "0.973" "1.707" "1.697" "2.371" "2.244" "9.5" "11.5" "15.8" "11.5" "11.9" "9.2" "16.2" "16.1" "22.4" "21.2" "" "" "" "" "" "" "" "" "" "" "8.4" "9.5" "13.8" "8.6" "9.9" "8.5" "13.7" "13.3" "20.6" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "408480103546989940" "False" "High" "IsMasterProtein" "Q9Y4C1" "Lysine-specific demethylase 3A OS=Homo sapiens OX=9606 GN=KDM3A PE=1 SV=4" "0.001" "False" "3.970" "1" "1" "1" "1" "1321" "147.2" "8.07" "3.05" "1" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "55818" "ENSG00000115548" "KDM3A" "D6W5M3; hsa:55818; Q53S72; Q68D47; Q68UT9; Q6N050; Q8IY08; Q9Y4C1" "HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression" "5" "0" "0.793" "0.978" "0.950" "0.752" "0.893" "1.103" "0.562" "0.842" "7.217" "42.7" "33.9" "41.8" "40.6" "32.1" "38.2" "47.1" "24.0" "36.0" "308.5" "" "" "" "" "" "" "" "" "" "" "37.9" "28.1" "36.5" "30.4" "26.8" "35.1" "39.8" "19.9" "33.0" "308.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723241537824497291" "False" "High" "IsMasterProtein" "Q02388" "Collagen alpha-1(VII) chain OS=Homo sapiens OX=9606 GN=COL7A1 PE=1 SV=2" "0.001" "False" "3.966" "1" "2" "2" "2" "2944" "295.0" "6.27" "5.25" "2" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00014, Pf00041, Pf00092, Pf01391" "1294" "ENSG00000114270" "COL7A1" "hsa:1294; Q02388; Q14054; Q16507" "Collagen degradation; Integrin cell surface interactions; Collagen chain trimerization; COPII-mediated vesicle transport; Cargo concentration in the ER; Laminin interactions; Anchoring fibril formation" "" "10" "0" "0.872" "0.832" "0.959" "0.869" "0.907" "1.003" "0.886" "0.942" "2.800" "538.2" "469.2" "447.6" "516.1" "467.5" "488.0" "539.7" "477.1" "507.1" "1507.0" "" "" "" "" "" "" "" "" "" "" "477.3" "388.6" "390.5" "386.0" "389.8" "448.3" "456.1" "394.3" "465.1" "1507.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871053517443562380" "False" "High" "IsMasterProtein" "P57772" "Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4" "0.001" "False" "3.963" "2" "1" "2" "1" "596" "65.3" "8.35" "5.11" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf21131, Pf21208" "60678" "ENSG00000132394; ENSG00000284869" "EEFSEC" "hsa:60678; P57772; Q96HZ6" "Selenocysteine synthesis" "Selenium metabolism and selenoproteins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1604052202135203910" "False" "High" "IsMasterProtein" "O00592" "Podocalyxin OS=Homo sapiens OX=9606 GN=PODXL PE=1 SV=2" "0.001" "False" "3.955" "2" "1" "1" "1" "558" "58.6" "5.49" "3.47" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06365" "5420" "ENSG00000128567" "PODXL" "A6NHX8; hsa:5420; O00592; Q52LZ7; Q53ER6" "" "Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Pleural mesothelioma" "5" "0" "1.045" "1.073" "1.138" "1.042" "0.926" "1.049" "1.029" "1.029" "0.565" "108.0" "112.8" "115.9" "122.8" "112.5" "100.0" "113.2" "111.1" "111.1" "61.0" "" "" "" "" "" "" "" "" "" "" "95.7" "93.5" "101.1" "91.9" "93.8" "91.8" "95.7" "91.8" "101.9" "61.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1113653796691851863" "False" "High" "IsMasterProtein" "Q86X83" "COMM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=COMMD2 PE=1 SV=2" "0.001" "False" "3.953" "10" "1" "1" "1" "199" "22.7" "6.73" "3.63" "1" "" "other cell component" "" "Pf07258" "51122" "ENSG00000114744" "COMMD2" "hsa:51122; Q561V4; Q86X83; Q9H3L5; Q9Y5V1" "Neddylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.001" "False" "3.952" "2" "1" "1" "1" "486" "56.2" "6.71" "3.64" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "27" "0" "1.025" "0.928" "1.351" "0.955" "0.832" "0.918" "0.621" "0.948" "5.840" "113.4" "116.1" "105.2" "153.2" "108.3" "94.3" "104.0" "70.3" "107.5" "662.0" "" "" "" "" "" "" "" "" "" "" "100.5" "96.2" "91.8" "114.5" "90.3" "86.6" "87.9" "58.1" "98.6" "662.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3945709348519994010" "False" "High" "IsMasterProtein" "Q96I23" "Protein preY, mitochondrial OS=Homo sapiens OX=9606 GN=PYURF PE=1 SV=1" "0.001" "False" "3.921" "12" "2" "3" "2" "114" "12.6" "9.33" "9.34" "2" "other biological processes" "other membranes;mitochondrion;ER/Golgi" "" "Pf03966" "100996939" "ENSG00000145337" "PYURF" "B2R571; hsa:100996939; Q96I23" "" "" "0" "0" "0.926" "0.755" "0.787" "0.685" "0.599" "0.577" "0.776" "0.822" "0.303" "1046.8" "968.8" "790.7" "823.7" "716.7" "627.5" "604.1" "812.0" "860.1" "317.1" "" "" "" "" "" "" "" "" "" "" "928.3" "802.5" "689.9" "616.1" "597.6" "576.4" "510.6" "671.2" "788.9" "317.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344145202623347770" "False" "High" "IsMasterProtein" "O60637" "Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=1 SV=1" "0.001" "False" "3.920" "6" "2" "2" "2" "253" "28.0" "5.81" "5.20" "2" "" "other membranes" "" "Pf00335" "10099" "ENSG00000140391" "TSPAN3" "A6NEH4; B3KQQ2; B4DP19; hsa:10099; O60637; Q9BW22; Q9NVX9" "" "" "0" "0" "1.016" "0.812" "1.049" "0.918" "1.072" "0.926" "0.880" "1.005" "0.577" "264.9" "269.1" "215.0" "277.7" "243.2" "284.0" "245.3" "233.2" "266.1" "152.8" "" "" "" "" "" "" "" "" "" "" "234.9" "222.9" "187.6" "207.7" "202.8" "260.9" "207.3" "192.8" "244.1" "152.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4512542596092401927" "False" "High" "IsMasterProtein" "Q15390" "Mitochondrial fission regulator 1 OS=Homo sapiens OX=9606 GN=MTFR1 PE=1 SV=2" "0.001" "False" "3.917" "3" "1" "1" "1" "333" "37.0" "9.01" "3.17" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf05308" "9650" "ENSG00000066855" "MTFR1" "E7EP84; hsa:9650; Q15390; Q6IB94; Q7Z669; Q86XH5; Q8IVD7" "" "" "0" "0" "1.029" "0.915" "0.830" "0.948" "0.699" "0.665" "0.608" "0.773" "0.668" "54.5" "56.1" "49.9" "45.3" "51.7" "38.1" "36.2" "33.1" "42.1" "36.4" "" "" "" "" "" "" "" "" "" "" "48.4" "46.5" "43.6" "33.9" "43.1" "35.0" "30.6" "27.4" "38.6" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728003267780759381" "False" "High" "IsMasterProtein" "Q8WV07" "Protein LTO1 homolog OS=Homo sapiens OX=9606 GN=LTO1 PE=1 SV=2" "0.001" "False" "3.917" "10" "2" "3" "2" "137" "15.3" "5.80" "8.65" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "" "Pf09811" "220064" "ENSG00000149716" "LTO1" "B2R4R2; hsa:220064; Q8NFK0; Q8WV07" "" "" "0" "0" "0.849" "0.920" "1.128" "0.931" "1.151" "1.081" "0.742" "1.078" "2.006" "81.4" "69.1" "74.9" "91.8" "75.8" "93.7" "88.0" "60.4" "87.8" "163.3" "" "" "" "" "" "" "" "" "" "" "72.2" "57.2" "65.3" "68.7" "63.2" "86.1" "74.4" "50.0" "80.5" "163.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4805951626840685734" "False" "High" "IsMasterProtein" "P50336" "Protoporphyrinogen oxidase OS=Homo sapiens OX=9606 GN=PPOX PE=1 SV=1" "0.001" "False" "3.916" "3" "1" "1" "1" "477" "50.7" "8.16" "3.68" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01593" "5498" "ENSG00000143224" "PPOX" "D3DVG0; hsa:5498; P50336; Q5VTW8" "Heme biosynthesis" "Orexin receptor pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "0.949" "0.916" "0.942" "0.838" "1.056" "0.834" "0.969" "0.918" "0.724" "157.4" "149.3" "144.2" "148.4" "131.9" "166.2" "131.3" "152.6" "144.6" "114.0" "" "" "" "" "" "" "" "" "" "" "139.6" "123.7" "125.8" "111.0" "110.0" "152.7" "110.9" "126.1" "132.6" "114.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551747306859767135" "False" "High" "IsMasterProtein" "Q86XZ4" "Spermatogenesis-associated serine-rich protein 2 OS=Homo sapiens OX=9606 GN=SPATS2 PE=1 SV=1" "0.001" "False" "3.915" "2" "1" "1" "1" "545" "59.5" "8.90" "2.89" "1" "" "cytosol;other cell component" "" "Pf07139" "65244" "ENSG00000123352" "SPATS2" "A8K8G9; hsa:65244; Q86XZ4; Q9H7D4; Q9H8Y7; Q9H8Z8" "" "" "0" "0" "1.039" "1.067" "1.039" "1.058" "1.040" "0.919" "0.973" "1.006" "1.950" "78.7" "81.8" "84.0" "81.8" "83.3" "81.9" "72.3" "76.6" "79.2" "153.5" "" "" "" "" "" "" "" "" "" "" "69.8" "67.8" "73.3" "61.1" "69.4" "75.2" "61.1" "63.3" "72.7" "153.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5731333323507382333" "False" "High" "IsMasterProtein" "Q8NB78" "Lysine-specific histone demethylase 2 OS=Homo sapiens OX=9606 GN=KDM1B PE=1 SV=3" "0.001" "False" "3.896" "1" "1" "1" "1" "822" "92.0" "7.87" "2.34" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01593, Pf04433, Pf07496" "221656" "ENSG00000165097" "KDM1B" "A2A2C5; A2A2C6; hsa:221656; Q5TGV3; Q6AI15; Q6ZUU4; Q8N258; Q8NB78; Q96EL7" "UCH proteinases; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "Vitamin D-sensitive calcium signaling in depression" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256301948778102802" "False" "High" "IsMasterProtein" "Q8NCE0" "tRNA-splicing endonuclease subunit Sen2 OS=Homo sapiens OX=9606 GN=TSEN2 PE=1 SV=2" "0.001" "False" "3.888" "6" "2" "2" "2" "465" "53.2" "7.85" "5.14" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01974, Pf02778" "80746" "ENSG00000154743" "TSEN2" "B7Z6K1; C9IZI7; G5E9Q3; hsa:80746; Q8NCE0; Q8WTW7; Q9BPU7" "tRNA processing in the nucleus" "" "1" "0" "1.200" "1.162" "1.049" "0.917" "1.351" "1.262" "1.619" "1.139" "3.838" "9.8" "11.8" "11.4" "10.3" "9.0" "13.3" "12.4" "15.9" "11.2" "37.7" "" "" "" "" "" "" "" "" "" "" "8.7" "9.8" "10.0" "7.7" "7.5" "12.2" "10.5" "13.1" "10.3" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7128094865721745487" "False" "High" "IsMasterProtein" "Q9UKL6" "Phosphatidylcholine transfer protein OS=Homo sapiens OX=9606 GN=PCTP PE=1 SV=1" "0.001" "False" "3.886" "5" "1" "1" "1" "214" "24.8" "5.78" "2.92" "1" "transport;other biological processes" "cytosol" "transporter activity;other molecular function" "Pf01852" "58488" "ENSG00000141179" "PCTP" "hsa:58488; Q9BSC9; Q9UIT3; Q9UKL6; Q9UKW7" "Mitochondrial Fatty Acid Beta-Oxidation; Synthesis of PC" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785490494886001566" "False" "High" "IsMasterProtein" "A6NC98" "Coiled-coil domain-containing protein 88B OS=Homo sapiens OX=9606 GN=CCDC88B PE=1 SV=1" "0.001" "False" "3.881" "1" "2" "2" "1" "1476" "164.7" "5.11" "4.39" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf19047" "283234" "ENSG00000168071" "CCDC88B" "A5D8Y5; A6NC98; B5MDM2; hsa:283234; Q05BL2; Q6RUV3; Q8N1Q6; Q8NF44; Q9H0H1" "" "" "0" "0" "0.939" "0.982" "0.777" "0.604" "1.004" "1.044" "1.098" "1.051" "7.298" "8.1" "7.6" "7.9" "6.3" "4.9" "8.1" "8.4" "8.9" "8.5" "58.9" "" "" "" "" "" "" "" "" "" "" "7.2" "6.3" "6.9" "4.7" "4.1" "7.4" "7.1" "7.3" "7.8" "58.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1287378347381502344" "False" "High" "IsMasterProtein" "O75558" "Syntaxin-11 OS=Homo sapiens OX=9606 GN=STX11 PE=1 SV=1" "0.001" "False" "3.853" "3" "2" "2" "2" "287" "33.2" "6.55" "6.59" "2" "cell-cell signaling;cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00804" "8676" "ENSG00000135604" "STX11" "E1P598; hsa:8676; O75378; O75558; O95148; Q5TCL6" "" "" "0" "0" "0.997" "0.726" "0.746" "0.503" "0.278" "0.431" "0.649" "0.641" "0.290" "206.7" "206.2" "150.1" "154.3" "104.0" "57.4" "89.1" "134.1" "132.5" "60.1" "" "" "" "" "" "" "" "" "" "" "183.3" "170.8" "130.9" "115.4" "86.7" "52.7" "75.3" "110.8" "121.5" "60.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8656179388413657305" "False" "High" "IsMasterProtein" "O00308" "NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2" "0.001" "False" "3.853" "1" "1" "1" "1" "870" "98.9" "7.12" "4.24" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00397, Pf00632" "11060" "ENSG00000198373" "WWP2" "A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; hsa:11060; I3RSG8; O00308; Q6ZTQ5; Q96CZ2; Q9BWN6" "RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle" "" "5" "0" "0.947" "0.802" "0.833" "1.029" "0.901" "0.951" "0.695" "0.960" "4.428" "53.7" "50.9" "43.1" "44.7" "55.3" "48.4" "51.1" "37.3" "51.5" "237.8" "" "" "" "" "" "" "" "" "" "" "47.6" "42.1" "37.6" "33.4" "46.1" "44.4" "43.2" "30.9" "47.3" "237.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6163739139500016116" "False" "High" "IsMasterProtein" "Q9BSQ5" "Cerebral cavernous malformations 2 protein OS=Homo sapiens OX=9606 GN=CCM2 PE=1 SV=1" "0.001" "False" "3.843" "2" "1" "1" "1" "444" "48.8" "5.54" "3.86" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion;other cell component" "" "Pf16545" "83605" "ENSG00000136280" "CCM2" "A4D2L4; B3KUV0; D3DVL4; E9PDJ3; F5H0E1; F5H551; hsa:83605; Q71RE5; Q8TAT4; Q9BSQ5" "" "" "0" "0" "1.375" "1.237" "1.406" "1.234" "1.136" "1.590" "1.220" "1.254" "1.544" "71.7" "98.5" "88.7" "100.7" "88.4" "81.4" "114.0" "87.4" "89.8" "110.6" "" "" "" "" "" "" "" "" "" "" "63.5" "81.6" "77.4" "75.3" "73.7" "74.7" "96.3" "72.3" "82.4" "110.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534936647316477695" "False" "High" "IsMasterProtein" "Q49AN0" "Cryptochrome-2 OS=Homo sapiens OX=9606 GN=CRY2 PE=1 SV=2" "0.001" "False" "3.840" "2" "1" "1" "1" "593" "66.9" "8.35" "3.72" "1" "transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00875, Pf03441" "1408" "ENSG00000121671" "CRY2" "B4DH32; B4DZD6; hsa:1408; O75148; Q49AN0; Q8IV71" "Circadian Clock" "Melatonin metabolism and effects; Exercise-induced circadian regulation; DYRK1A involvement regarding cell proliferation in brain development; 11p11.2 copy number variation syndrome ; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7824146084782437899" "False" "High" "IsMasterProtein" "P41162" "ETS translocation variant 3 OS=Homo sapiens OX=9606 GN=ETV3 PE=1 SV=2" "0.001" "False" "3.836" "3" "1" "1" "1" "512" "57.0" "8.57" "4.32" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "2117" "ENSG00000117036" "ETV3" "B4E3M7; hsa:2117; P41162; Q8TAC8; Q9BX30" "" "" "0" "0" "1.117" "0.990" "1.046" "0.967" "0.938" "0.834" "0.910" "1.068" "1.598" "63.0" "70.4" "62.4" "66.0" "60.9" "59.1" "52.6" "57.3" "67.3" "100.7" "" "" "" "" "" "" "" "" "" "" "55.9" "58.3" "54.5" "49.3" "50.8" "54.3" "44.4" "47.4" "61.8" "100.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3006395004919527007" "False" "High" "IsMasterProtein" "Q9BUP3" "Oxidoreductase HTATIP2 OS=Homo sapiens OX=9606 GN=HTATIP2 PE=1 SV=2" "0.001" "False" "3.834" "9" "1" "1" "1" "242" "27.0" "8.38" "2.98" "1" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf13460" "10553" "ENSG00000109854" "HTATIP2" "A8K7S7; D3DQY8; hsa:10553; O15383; O60520; O95345; Q53GC1; Q53GG2; Q6IBI3; Q9BUP3" "" "" "0" "0" "0.686" "0.560" "1.068" "0.744" "0.923" "0.928" "1.043" "0.768" "0.714" "30.9" "21.2" "17.3" "33.0" "23.0" "28.5" "28.6" "32.2" "23.7" "22.0" "" "" "" "" "" "" "" "" "" "" "27.4" "17.5" "15.1" "24.7" "19.1" "26.2" "24.2" "26.6" "21.8" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "485577591804044204" "False" "High" "IsMasterProtein" "Q96Q45" "Transmembrane protein 237 OS=Homo sapiens OX=9606 GN=TMEM237 PE=1 SV=2" "0.001" "False" "3.833" "3" "1" "1" "1" "408" "45.5" "6.47" "3.45" "1" "cell organization and biogenesis;other biological processes" "other cell component" "" "Pf15383" "65062" "ENSG00000155755" "TMEM237" "B4E1R8; B4E2R8; E9PAR8; E9PBF8; E9PG24; E9PGX0; hsa:65062; Q53TS9; Q53TT2; Q7Z3B6; Q8IZ18; Q8NBF8; Q96CY1; Q96Q45" "" "Joubert syndrome; Ciliopathies" "2" "0" "0.942" "0.959" "0.881" "0.815" "1.000" "0.733" "0.922" "1.137" "0.375" "98.5" "92.7" "94.5" "86.8" "80.3" "98.5" "72.2" "90.8" "112.0" "36.9" "" "" "" "" "" "" "" "" "" "" "87.4" "76.8" "82.4" "64.9" "67.0" "90.5" "61.1" "75.1" "102.7" "36.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2856419358086273541" "False" "High" "IsMasterProtein" "Q93073" "Selenocysteine insertion sequence-binding protein 2-like OS=Homo sapiens OX=9606 GN=SECISBP2L PE=1 SV=3" "0.001" "False" "3.823" "2" "2" "2" "2" "1101" "121.7" "6.04" "4.92" "2" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "9728" "ENSG00000138593" "SECISBP2L" "hsa:9728; Q8N767; Q93073" "" "Thyroid hormones production and peripheral downstream signaling effects" "1" "0" "0.832" "0.920" "1.170" "0.930" "0.896" "0.833" "0.627" "1.002" "2.829" "23.4" "19.5" "21.5" "27.4" "21.8" "21.0" "19.5" "14.7" "23.5" "66.3" "" "" "" "" "" "" "" "" "" "" "20.8" "16.2" "18.8" "20.5" "18.2" "19.3" "16.5" "12.1" "21.5" "66.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6240183344312485010" "False" "High" "IsMasterProtein" "O00391" "Sulfhydryl oxidase 1 OS=Homo sapiens OX=9606 GN=QSOX1 PE=1 SV=3" "0.001" "False" "3.793" "1" "1" "1" "1" "747" "82.5" "8.92" "2.49" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf04777, Pf18108, Pf18371" "5768" "ENSG00000116260" "QSOX1" "hsa:5768; O00391; Q59G29; Q5T2X0; Q8TDL6; Q8WVP4" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431062919970507924" "False" "High" "IsMasterProtein" "P62891" "Large ribosomal subunit protein eL39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2" "0.001" "False" "3.791" "20" "1" "2" "1" "51" "6.4" "12.56" "9.26" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00832" "6170" "ENSG00000198918" "RPL39" "hsa:6170; P02404; P39025; P62891; Q9BYF2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.029" "1.141" "1.187" "1.177" "1.140" "1.299" "1.182" "1.229" "0.848" "189.1" "194.6" "215.7" "224.5" "222.6" "215.6" "245.7" "223.6" "232.4" "160.3" "" "" "" "" "" "" "" "" "" "" "167.7" "161.2" "188.2" "167.9" "185.6" "198.1" "207.7" "184.8" "213.2" "160.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6342285970436861386" "False" "High" "IsMasterProtein" "Q9UPM8" "AP-4 complex subunit epsilon-1 OS=Homo sapiens OX=9606 GN=AP4E1 PE=1 SV=2" "0.001" "False" "3.783" "1" "1" "1" "1" "1137" "127.2" "5.99" "3.60" "1" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf14807" "23431" "ENSG00000081014" "AP4E1" "A0AVD6; A1L4A9; A6NNX7; H0YKX4; hsa:23431; Q68D31; Q9UPM8; Q9Y588" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "" "2" "0" "0.869" "0.920" "0.974" "0.839" "0.879" "0.823" "0.792" "0.907" "1.555" "75.7" "65.8" "69.7" "73.8" "63.6" "66.6" "62.3" "60.0" "68.7" "117.8" "" "" "" "" "" "" "" "" "" "" "67.2" "54.5" "60.8" "55.2" "53.0" "61.1" "52.6" "49.6" "63.0" "117.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2217826250867961619" "False" "High" "IsMasterProtein" "Q6P4F2" "Ferredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=FDX2 PE=1 SV=3" "0.001" "False" "3.778" "6" "1" "1" "1" "183" "19.5" "5.38" "3.85" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00111" "112812" "ENSG00000267673" "FDX2" "B7Z6L7; Q6P4F2; Q8N8B8" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "" "5" "0" "0.974" "0.911" "0.973" "1.127" "1.149" "1.002" "0.954" "0.912" "0.551" "46.4" "45.2" "42.3" "45.2" "52.4" "53.3" "46.5" "44.3" "42.3" "25.6" "" "" "" "" "" "" "" "" "" "" "41.2" "37.5" "36.9" "33.8" "43.7" "49.0" "39.3" "36.6" "38.8" "25.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-530049988606756436" "False" "High" "IsMasterProtein" "Cont_P01030" "Complement C4 (Fragments) OS=Bos taurus OX=9913 GN=C4 PE=1 SV=2" "0.001" "True" "3.776" "2" "2" "2" "1" "920" "101.8" "6.58" "6.08" "2" "stress response;other biological processes" "non-structural extracellular;other cell component" "" "" "" "" "C4" "P01030; Q27992; Q27993" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "High" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.001" "False" "3.771" "1" "1" "1" "1" "1104" "122.8" "5.83" "3.45" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Glycosphingolipid transport; RHOF GTPase cycle" "" "7" "0" "1.646" "1.242" "1.975" "1.742" "1.148" "1.411" "1.406" "1.557" "2.495" "35.7" "58.8" "44.4" "70.5" "62.2" "41.0" "50.4" "50.2" "55.6" "89.1" "" "" "" "" "" "" "" "" "" "" "31.7" "48.7" "38.7" "52.8" "51.9" "37.6" "42.6" "41.5" "51.0" "89.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8545546198445454404" "False" "High" "IsMasterProtein" "E5RHQ5" "Nuclear pore complex-interacting protein family member B11 OS=Homo sapiens OX=9606 GN=NPIPB11 PE=3 SV=1" "0.001" "False" "3.763" "1" "1" "1" "1" "1161" "129.1" "10.04" "2.63" "1" "" "other membranes" "" "Pf06409, Pf20885" "" "ENSG00000254206" "NPIPB11" "E5RHQ5" "" "" "0" "0" "0.945" "0.849" "0.951" "0.931" "0.911" "0.947" "0.942" "0.919" "0.161" "264.3" "249.9" "224.4" "251.3" "246.0" "240.9" "250.3" "249.1" "243.0" "42.7" "" "" "" "" "" "" "" "" "" "" "234.4" "207.0" "195.8" "187.9" "205.1" "221.3" "211.5" "205.9" "222.9" "42.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693262599836950092" "False" "High" "IsMasterProtein" "Q06643" "Lymphotoxin-beta OS=Homo sapiens OX=9606 GN=LTB PE=1 SV=1" "0.001" "False" "3.762" "4" "1" "1" "1" "244" "25.4" "5.38" "2.91" "1" "cell-cell signaling;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf00229" "4050" "ENSG00000204487; ENSG00000206437; ENSG00000223448; ENSG00000227507; ENSG00000231314; ENSG00000236237; ENSG00000236925; ENSG00000238114" "LTB" "hsa:4050; P78370; Q06643; Q52LU8; Q99761" "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" "Spinal cord injury; EDA signaling in hair follicle development; IL-18 signaling pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "High" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.001" "False" "3.761" "3" "1" "1" "1" "385" "44.1" "6.23" "3.57" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "8" "0" "1.267" "0.773" "1.288" "0.903" "0.949" "0.826" "0.442" "1.000" "10.336" "24.9" "31.5" "19.2" "32.0" "22.4" "23.6" "20.5" "11.0" "24.9" "257.0" "" "" "" "" "" "" "" "" "" "" "22.0" "26.1" "16.8" "24.0" "18.7" "21.7" "17.4" "9.1" "22.8" "257.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7856478198222126423" "False" "High" "IsMasterProtein" "Q8N5F7" "NF-kappa-B-activating protein OS=Homo sapiens OX=9606 GN=NKAP PE=1 SV=1" "0.001" "False" "3.761" "3" "1" "1" "1" "415" "47.1" "10.11" "2.51" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf06047, Pf15692" "79576" "ENSG00000101882" "NKAP" "hsa:79576; Q6IPW6; Q8N5F7; Q96BQ2; Q9H638" "mRNA Splicing - Major Pathway" "" "1" "0" "0.952" "0.799" "0.660" "0.732" "0.697" "0.766" "0.901" "0.774" "0.305" "33.5" "31.9" "26.8" "22.1" "24.5" "23.4" "25.7" "30.2" "26.0" "10.2" "" "" "" "" "" "" "" "" "" "" "29.7" "26.4" "23.4" "16.6" "20.5" "21.5" "21.7" "25.0" "23.8" "10.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408617602849881412" "False" "High" "IsMasterProtein" "Q9UKU7" "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1" "0.001" "False" "3.758" "5" "2" "2" "2" "415" "45.0" "7.85" "2.26" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "27034" "ENSG00000151498" "ACAD8" "B7Z5W4; hsa:27034; Q6ZWP6; Q9BUS8; Q9UKU7" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "" "2" "0" "1.060" "0.880" "1.142" "1.014" "1.064" "1.093" "1.120" "0.833" "0.909" "102.7" "108.9" "90.3" "117.3" "104.1" "109.2" "112.3" "115.1" "85.6" "93.4" "" "" "" "" "" "" "" "" "" "" "91.1" "90.2" "78.8" "87.7" "86.8" "100.4" "94.9" "95.1" "78.5" "93.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986352754293277242" "False" "High" "IsMasterProtein" "P61513" "Large ribosomal subunit protein eL43 OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2" "0.001" "False" "3.742" "18" "2" "2" "2" "92" "10.3" "10.43" "6.07" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01780" "6168" "ENSG00000197756" "RPL37A" "hsa:6168; P12751; P61513; Q6FGF5" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.170" "1.117" "1.161" "1.277" "1.130" "0.902" "1.083" "1.219" "1.001" "171.8" "201.1" "192.0" "199.4" "219.4" "194.2" "155.1" "186.0" "209.4" "171.9" "" "" "" "" "" "" "" "" "" "" "152.4" "166.6" "167.5" "149.2" "182.9" "178.4" "131.1" "153.8" "192.0" "171.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2668394544474588816" "False" "High" "IsMasterProtein" "Q99470" "Stromal cell-derived factor 2 OS=Homo sapiens OX=9606 GN=SDF2 PE=1 SV=2" "0.001" "False" "3.739" "7" "2" "2" "2" "211" "23.0" "7.33" "4.84" "2" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf02815" "6388" "ENSG00000132581" "SDF2" "hsa:6388; Q99470; Q9BQ79" "" "" "0" "0" "1.076" "1.007" "1.148" "1.062" "1.148" "1.109" "1.184" "1.182" "1.506" "157.1" "169.0" "158.2" "180.4" "166.8" "180.4" "174.2" "186.0" "185.8" "236.7" "" "" "" "" "" "" "" "" "" "" "139.3" "140.0" "138.0" "134.9" "139.1" "165.7" "147.3" "153.8" "170.4" "236.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099324451451245677" "False" "High" "IsMasterProtein" "Q56VL3" "OCIA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=OCIAD2 PE=1 SV=1" "0.001" "False" "3.738" "6" "1" "1" "1" "154" "16.9" "9.03" "2.62" "1" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "132299" "ENSG00000145247" "OCIAD2" "B4DPE7; hsa:132299; Q56VL3; Q8N544" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1511141278890819027" "False" "High" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "0.001" "False" "3.738" "1" "1" "1" "1" "1390" "155.5" "8.48" "2.65" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5331704730055142476" "False" "High" "IsMasterProtein" "Q8IVB5" "LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=1 SV=1" "0.002" "False" "3.727" "5" "2" "3" "2" "337" "36.5" "8.56" "7.77" "2" "cell organization and biogenesis;other metabolic processes" "other cell component" "" "Pf14954" "128077" "ENSG00000271601" "LIX1L" "hsa:128077; Q6AI36; Q8IVB5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802052166726839277" "False" "High" "IsMasterProtein" "O75884" "Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2" "0.002" "False" "3.727" "4" "1" "2" "1" "186" "21.0" "6.20" "6.47" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf06821" "10741" "ENSG00000089050" "RBBP9" "D3DW31; hsa:10741; O75884; Q5JPH9; Q9H1D8" "" "" "0" "0" "0.912" "0.962" "0.989" "0.890" "0.630" "1.007" "0.712" "0.861" "6.369" "127.2" "115.9" "122.3" "125.8" "113.2" "80.2" "128.1" "90.6" "109.5" "810.1" "" "" "" "" "" "" "" "" "" "" "112.8" "96.0" "106.8" "94.1" "94.4" "73.7" "108.3" "74.9" "100.4" "810.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2183625062591563072" "False" "High" "IsMasterProtein" "Q9NZT1" "Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2" "0.002" "False" "3.725" "16" "1" "1" "1" "146" "15.9" "4.44" "2.88" "1" "signal transduction;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "51806" "ENSG00000178372" "CALML5" "hsa:51806; Q5SQI3; Q8IXU8; Q9NZT1" "Neutrophil degranulation" "Alzheimer's disease and miRNA effects; Ras signaling; Melanoma; Alzheimer's disease" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370234138651289741" "False" "High" "IsMasterProtein" "Q96RS0" "Trimethylguanosine synthase OS=Homo sapiens OX=9606 GN=TGS1 PE=1 SV=3" "0.002" "False" "3.713" "3" "1" "1" "1" "853" "96.6" "4.94" "3.29" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09445" "96764" "ENSG00000137574" "TGS1" "A6NJQ5; hsa:96764; Q5GH23; Q8TDG9; Q96QU3; Q96RS0; Q9H5V3" "Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly" "" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808375425283248797" "False" "High" "IsMasterProtein" "Q13572" "Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2" "0.002" "False" "3.706" "2" "1" "1" "1" "414" "45.6" "6.16" "3.29" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf05770, Pf17927" "3705" "ENSG00000100605; ENSG00000274958" "ITPK1" "hsa:3705; Q13572; Q9BTL6; Q9H2E7" "Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol" "2q37 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7943802449563468851" "False" "High" "IsMasterProtein" "Q6ZU80" "Centrosomal protein of 128 kDa OS=Homo sapiens OX=9606 GN=CEP128 PE=1 SV=2" "0.002" "False" "3.702" "1" "1" "1" "1" "1094" "127.9" "6.52" "2.91" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "145508" "ENSG00000100629" "CEP128" "B9EK52; hsa:145508; Q6ZU80; Q86X97; Q96ML4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.002" "False" "3.700" "4" "2" "2" "2" "527" "59.3" "6.76" "6.11" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "Post-chaperonin tubulin folding pathway" "" "1" "0" "1.702" "1.300" "1.383" "1.281" "1.419" "1.420" "0.104" "1.020" "12.389" "25.5" "43.4" "33.2" "35.3" "32.7" "36.2" "36.2" "2.7" "26.0" "316.2" "" "" "" "" "" "" "" "" "" "" "22.6" "36.0" "29.0" "26.4" "27.3" "33.3" "30.6" "2.2" "23.9" "316.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6884862282451345768" "False" "High" "IsMasterProtein" "Q9Y232" "Chromodomain Y-like protein OS=Homo sapiens OX=9606 GN=CDYL PE=1 SV=2" "0.002" "False" "3.693" "2" "1" "1" "1" "598" "66.4" "9.45" "2.37" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00378, Pf00385" "9425" "ENSG00000153046" "CDYL" "A8K6D6; B4DLG4; hsa:9425; Q0VDG7; Q32NC5; Q5VX99; Q6P7T5; Q9BWZ2; Q9Y232; Q9Y424" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262734157985051002" "False" "High" "IsMasterProtein" "Q9H7H0" "Ribosome assembly protein METTL17, mitochondrial OS=Homo sapiens OX=9606 GN=METTL17 PE=1 SV=1" "0.002" "False" "3.690" "2" "1" "1" "1" "456" "50.7" "9.33" "3.03" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf09243" "64745" "ENSG00000165792" "METTL17" "hsa:64745; Q9BSH1; Q9BZH2; Q9BZH3; Q9H7H0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6391839617332390225" "False" "High" "IsMasterProtein" "P07203" "Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4" "0.002" "False" "3.684" "5" "1" "1" "1" "203" "22.1" "6.55" "3.32" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00255" "2876" "ENSG00000233276" "GPX1" "E9PAS1; hsa:2876; P07203; Q7Z5H1; Q9BW12" "Detoxification of Reactive Oxygen Species; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; One-carbon metabolism and related pathways; TYROBP causal network in microglia; Oxidative stress response; Male infertility; p53 transcriptional gene network; Omega-6-fatty acids in senescence" "18" "0" "1.022" "0.835" "1.099" "1.046" "0.891" "1.012" "0.948" "0.850" "0.541" "93.7" "95.7" "78.2" "102.9" "97.9" "83.4" "94.8" "88.8" "79.6" "50.7" "" "" "" "" "" "" "" "" "" "" "83.1" "79.3" "68.2" "77.0" "81.7" "76.6" "80.1" "73.4" "73.0" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5644554619979627576" "False" "High" "IsMasterProtein" "O75251" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3" "0.002" "False" "3.680" "4" "1" "1" "1" "213" "23.5" "9.99" "3.43" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01058" "374291" "ENSG00000115286" "NDUFS7" "B3KRI2; hsa:374291; O75251; Q2T9H7; Q9BV17" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "1.152" "0.928" "1.260" "1.044" "1.038" "1.141" "1.001" "0.842" "0.685" "161.4" "186.0" "149.9" "203.5" "168.5" "167.5" "184.2" "161.7" "135.9" "110.5" "" "" "" "" "" "" "" "" "" "" "143.2" "154.1" "130.8" "152.2" "140.5" "153.9" "155.7" "133.6" "124.6" "110.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530850700352278513" "False" "High" "IsMasterProtein" "Q15700" "Disks large homolog 2 OS=Homo sapiens OX=9606 GN=DLG2 PE=1 SV=3" "0.002" "False" "3.667" "2" "2" "4" "2" "870" "97.5" "6.47" "9.39" "2" "cell adhesion;cell-cell signaling;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600, Pf10608" "1740" "ENSG00000150672" "DLG2" "B7WNY8; F8W9V6; hsa:1740; Q15700; Q59G57; Q5H9Q4; Q68CQ8; Q6ZTA8" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation" "Disruption of postsynaptic signaling by CNV; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "10" "0" "0.960" "0.922" "1.012" "0.959" "1.058" "0.979" "1.031" "0.774" "0.356" "450.8" "432.7" "415.7" "456.4" "432.2" "477.0" "441.5" "464.7" "348.8" "160.6" "" "" "" "" "" "" "" "" "" "" "399.7" "358.4" "362.7" "341.3" "360.4" "438.2" "373.1" "384.1" "319.9" "160.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-11749500110992675" "False" "High" "IsMasterProtein" "Q92995" "Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2" "0.002" "False" "3.664" "2" "2" "2" "2" "863" "97.3" "5.53" "4.96" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8975" "ENSG00000058056" "USP13" "A8K2S3; B4DYF3; D3DNS2; hsa:8975; Q92995; Q96B25" "Ub-specific processing proteases; Regulation of PTEN stability and activity" "" "2" "0" "0.996" "0.838" "1.151" "0.990" "0.804" "0.835" "0.821" "0.830" "3.975" "108.8" "108.3" "91.2" "125.2" "107.7" "87.4" "90.8" "89.3" "90.3" "432.4" "" "" "" "" "" "" "" "" "" "" "96.5" "89.7" "79.6" "93.6" "89.8" "80.3" "76.8" "73.8" "82.8" "432.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2353077507000470893" "False" "High" "IsMasterProtein" "Q6PI98" "INO80 complex subunit C OS=Homo sapiens OX=9606 GN=INO80C PE=1 SV=1" "0.002" "False" "3.659" "6" "1" "1" "1" "192" "20.6" "10.02" "2.57" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08265" "125476" "ENSG00000153391" "INO80C" "B4DUI4; E9PCS7; hsa:125476; Q6PI98; Q86WR1; Q8N994" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "1.097" "0.854" "1.623" "1.191" "0.822" "1.462" "1.000" "0.877" "2.012" "115.5" "126.7" "98.6" "187.5" "137.6" "95.0" "168.9" "115.5" "101.3" "232.4" "" "" "" "" "" "" "" "" "" "" "102.4" "105.0" "86.1" "140.2" "114.7" "87.3" "142.7" "95.5" "92.9" "232.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4955977949004154122" "False" "High" "IsMasterProtein" "Q9NRW3" "DNA dC->dU-editing enzyme APOBEC-3C OS=Homo sapiens OX=9606 GN=APOBEC3C PE=1 SV=2" "0.002" "False" "3.656" "7" "1" "1" "1" "190" "22.8" "7.59" "2.54" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf18782" "27350" "ENSG00000244509" "APOBEC3C" "B2R884; hsa:27350; Q5JZ92; Q7Z2N7; Q96F12; Q9NRW3" "Formation of the Editosome" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.002" "False" "3.651" "6" "1" "1" "1" "204" "23.7" "5.67" "3.90" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.045" "0.840" "1.086" "1.022" "0.908" "1.050" "0.980" "0.892" "1.411" "210.2" "219.7" "176.6" "228.3" "214.9" "190.9" "220.8" "206.1" "187.6" "296.7" "" "" "" "" "" "" "" "" "" "" "186.4" "182.0" "154.1" "170.7" "179.2" "175.4" "186.6" "170.4" "172.1" "296.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4761760755167772661" "False" "High" "IsMasterProtein" "Q9GZR2" "RNA exonuclease 4 OS=Homo sapiens OX=9606 GN=REXO4 PE=1 SV=2" "0.002" "False" "3.648" "2" "1" "1" "1" "422" "46.6" "9.77" "3.63" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00929" "57109" "ENSG00000148300; ENSG00000280706" "REXO4" "B2RAT2; hsa:57109; Q5T8S4; Q5T8S5; Q5T8S6; Q9GZR2; Q9GZW3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "High" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.002" "False" "3.640" "3" "1" "1" "1" "296" "33.2" "9.26" "3.85" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "0.874" "0.782" "1.155" "0.992" "0.814" "0.840" "0.723" "0.799" "4.378" "44.5" "38.9" "34.8" "51.4" "44.1" "36.2" "37.4" "32.2" "35.6" "194.9" "" "" "" "" "" "" "" "" "" "" "39.5" "32.2" "30.4" "38.4" "36.8" "33.3" "31.6" "26.6" "32.6" "194.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2890677899884632439" "False" "High" "IsMasterProtein" "Q01201" "Transcription factor RelB OS=Homo sapiens OX=9606 GN=RELB PE=1 SV=2" "0.002" "False" "3.634" "3" "2" "2" "2" "579" "62.1" "6.24" "4.04" "2" "stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179, Pf16180, Pf16181" "5971" "ENSG00000104856" "RELB" "hsa:5971; Q01201; Q6GTX7; Q9UEI7" "Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; CD209 (DC-SIGN) signaling" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; EDA signaling in hair follicle development; Ebola virus infection in host; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Osteoarthritic chondrocyte hypertrophy" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981490796003058050" "False" "High" "IsMasterProtein" "Q9H4P4" "E3 ubiquitin-protein ligase NRDP1 OS=Homo sapiens OX=9606 GN=RNF41 PE=1 SV=2" "0.002" "False" "3.634" "3" "1" "2" "1" "317" "35.9" "6.14" "6.50" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08941, Pf13923" "10193" "ENSG00000181852" "RNF41" "A6NFW0; B2RBT8; hsa:10193; O75598; Q9H4P4" "Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB2:ERBB3 signaling" "" "2" "0" "1.285" "0.958" "1.232" "1.115" "1.312" "0.872" "0.597" "1.252" "2.084" "30.0" "38.6" "28.7" "37.0" "33.5" "39.4" "26.2" "17.9" "37.6" "62.5" "" "" "" "" "" "" "" "" "" "" "26.6" "31.9" "25.1" "27.6" "27.9" "36.2" "22.1" "14.8" "34.5" "62.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1247972566185408077" "False" "High" "IsMasterProtein" "Q9UNT1" "Rab-like protein 2B OS=Homo sapiens OX=9606 GN=RABL2B PE=1 SV=1" "0.002" "False" "3.633" "8" "2" "2" "2" "228" "26.1" "4.89" "5.39" "2" "cell organization and biogenesis;transport" "cytoskeleton;other cell component" "other molecular function" "Pf00071" "11158" "ENSG00000079974" "RABL2B" "hsa:11158; Q5TZT8; Q96C33; Q9UNT1" "" "3q29 copy number variation syndrome" "1" "0" "0.999" "0.938" "1.107" "1.036" "1.027" "1.032" "0.944" "0.927" "1.537" "153.5" "153.4" "144.0" "169.9" "159.1" "157.7" "158.4" "144.9" "142.3" "236.0" "" "" "" "" "" "" "" "" "" "" "136.1" "127.0" "125.7" "127.0" "132.6" "144.9" "133.9" "119.8" "130.5" "236.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1149947407616018825" "False" "High" "IsMasterProtein" "Q9NTX7" "E3 ubiquitin-protein ligase RNF146 OS=Homo sapiens OX=9606 GN=RNF146 PE=1 SV=1" "0.002" "False" "3.617" "4" "1" "3" "1" "359" "38.9" "5.33" "7.91" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02825, Pf13920" "81847" "ENSG00000118518" "RNF146" "E1P572; hsa:81847; Q6FIB2; Q7L8H4; Q96K03; Q96T06; Q9NTX6; Q9NTX7" "Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4270729495226616365" "False" "High" "IsMasterProtein" "Q9Y535" "DNA-directed RNA polymerase III subunit RPC8 OS=Homo sapiens OX=9606 GN=POLR3H PE=1 SV=1" "0.002" "False" "3.613" "5" "1" "1" "1" "204" "22.9" "4.58" "3.06" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03876, Pf08292" "171568" "ENSG00000100413" "POLR3H" "B0QYH9; hsa:171568; Q5M7Y8; Q96AE3; Q9BY95; Q9Y535" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; Primary ovarian insufficiency" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "445777244130660815" "False" "High" "IsMasterProtein" "Q76N32" "Centrosomal protein of 68 kDa OS=Homo sapiens OX=9606 GN=CEP68 PE=1 SV=2" "0.002" "False" "3.602" "1" "1" "2" "1" "757" "81.1" "5.16" "2.77" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "23177" "ENSG00000011523" "CEP68" "B4DRQ1; D6W5F1; D6W5F2; hsa:23177; O60326; Q76N32; Q9BQ18; Q9UDM9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2751730392985219929" "False" "High" "IsMasterProtein" "P09669" "Cytochrome c oxidase subunit 6C OS=Homo sapiens OX=9606 GN=COX6C PE=1 SV=2" "0.002" "False" "3.590" "11" "1" "2" "1" "75" "8.8" "10.39" "5.59" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02937" "1345" "ENSG00000164919" "COX6C" "B2R4D7; hsa:1345; P09669" "TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043642977461230788" "False" "High" "IsMasterProtein" "Q92575" "UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2" "0.002" "False" "3.588" "3" "2" "2" "2" "508" "56.7" "6.38" "5.82" "2" "stress response" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf00789" "23190" "ENSG00000144224" "UBXN4" "A8K9W4; hsa:23190; Q4ZG56; Q8IYM5; Q92575" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2283419122391357663" "False" "High" "IsMasterProtein" "Cont_Q05B55" "IGK protein OS=Bos taurus OX=9913 GN=IGK PE=2 SV=1" "0.002" "True" "3.583" "9" "1" "1" "1" "240" "26.6" "6.54" "1.79" "1" "" "" "" "Pf07654, Pf07686" "" "" "IGK" "Q05B55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865861446448502197" "False" "High" "IsMasterProtein" "Q9Y2U9" "Kelch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KLHDC2 PE=1 SV=1" "0.002" "False" "3.578" "3" "1" "1" "1" "406" "46.1" "6.61" "3.32" "1" "protein metabolism;other metabolic processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf13418" "23588" "ENSG00000165516" "KLHDC2" "B3KPF9; hsa:23588; Q6IAF0; Q86TY9; Q9Y2U9" "" "" "0" "0" "1.007" "0.791" "1.169" "0.729" "0.903" "0.822" "0.938" "0.861" "1.845" "29.5" "29.7" "23.4" "34.5" "21.5" "26.7" "24.3" "27.7" "25.4" "54.5" "" "" "" "" "" "" "" "" "" "" "26.2" "24.6" "20.4" "25.8" "17.9" "24.5" "20.5" "22.9" "23.3" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821127370945399140" "False" "High" "IsMasterProtein" "Q5JVF3" "PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2" "0.002" "False" "3.572" "2" "1" "1" "1" "399" "46.0" "8.53" "3.69" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01399" "55795" "ENSG00000126226" "PCID2" "A6NK09; hsa:55795; Q3ZCX1; Q5JVF3; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6383269344633082517" "False" "High" "IsMasterProtein" "Q8WTW3" "Conserved oligomeric Golgi complex subunit 1 OS=Homo sapiens OX=9606 GN=COG1 PE=1 SV=1" "0.002" "False" "3.555" "1" "1" "1" "1" "980" "108.9" "7.31" "2.59" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf08700" "9382" "ENSG00000166685" "COG1" "hsa:9382; Q8WTW3; Q9NPV9; Q9P2G6" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1896906962302585686" "False" "High" "IsMasterProtein" "Q96J42" "Thioredoxin domain-containing protein 15 OS=Homo sapiens OX=9606 GN=TXNDC15 PE=1 SV=1" "0.002" "False" "3.552" "5" "1" "1" "1" "360" "39.9" "4.83" "1.72" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf00085" "79770" "ENSG00000113621" "TXNDC15" "D3DQA9; hsa:79770; Q96J42; Q96MT2; Q9H639" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703495334451703375" "False" "High" "IsMasterProtein" "O94782" "Ubiquitin carboxyl-terminal hydrolase 1 OS=Homo sapiens OX=9606 GN=USP1 PE=1 SV=1" "0.002" "False" "3.547" "1" "1" "2" "1" "785" "88.2" "5.45" "3.18" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443" "7398" "ENSG00000162607" "USP1" "A0PJ95; D3DQ57; hsa:7398; O94782; Q05BX7; Q59H66; Q9UFR0; Q9UNJ3" "Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex" "miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network" "4" "0" "1.034" "0.560" "1.073" "0.925" "0.798" "0.672" "0.512" "0.851" "2.288" "12.3" "12.7" "6.9" "13.2" "11.4" "9.8" "8.3" "6.3" "10.5" "28.1" "" "" "" "" "" "" "" "" "" "" "10.9" "10.5" "6.0" "9.9" "9.5" "9.0" "7.0" "5.2" "9.6" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7198210632893501960" "False" "High" "IsMasterProtein" "Q07864" "DNA polymerase epsilon catalytic subunit A OS=Homo sapiens OX=9606 GN=POLE PE=1 SV=5" "0.002" "False" "3.545" "0" "1" "1" "1" "2286" "261.4" "6.39" "2.94" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08490" "5426" "ENSG00000177084" "POLE" "hsa:5426; Q07864; Q13533; Q86VH9" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "19" "0" "1.127" "1.162" "1.306" "0.938" "0.987" "1.187" "0.541" "1.292" "16.643" "17.3" "19.4" "20.1" "22.5" "16.2" "17.0" "20.5" "9.3" "22.3" "287.2" "" "" "" "" "" "" "" "" "" "" "15.3" "16.1" "17.5" "16.9" "13.5" "15.6" "17.3" "7.7" "20.4" "287.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8231836584422235478" "False" "High" "IsMasterProtein" "O15533" "Tapasin OS=Homo sapiens OX=9606 GN=TAPBP PE=1 SV=2" "0.002" "False" "3.543" "2" "1" "1" "1" "448" "47.5" "6.99" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf07654" "6892" "ENSG00000112493; ENSG00000206208; ENSG00000206281; ENSG00000231925; ENSG00000236490" "TAPBP" "A2AB91; A2ABC0; B0V003; B0V0A6; B2ZUA4; E9PGM2; hsa:6892; O15210; O15272; O15533; Q5STJ8; Q5STK6; Q5STQ5; Q5STQ6; Q66K65; Q96KK7; Q9HAN8; Q9UEE0; Q9UEE4; Q9UIZ6; Q9Y6K2" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855314221236891810" "False" "High" "IsMasterProtein" "Q5T0F9" "Coiled-coil and C2 domain-containing protein 1B OS=Homo sapiens OX=9606 GN=CC2D1B PE=1 SV=1" "0.002" "False" "3.536" "4" "2" "2" "2" "858" "94.2" "5.26" "7.14" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "200014" "ENSG00000154222" "CC2D1B" "hsa:200014; Q49AE8; Q5T0F8; Q5T0F9; Q5T0G0; Q6ZNQ1; Q96AP3; Q96I04; Q96JJ1" "Sealing of the nuclear envelope (NE) by ESCRT-III" "" "1" "0" "1.126" "0.989" "1.310" "1.326" "1.013" "1.290" "1.147" "1.040" "0.936" "116.6" "131.3" "115.3" "152.7" "154.7" "118.1" "150.5" "133.8" "121.2" "109.2" "" "" "" "" "" "" "" "" "" "" "103.4" "108.8" "100.6" "114.2" "129.0" "108.5" "127.2" "110.6" "111.2" "109.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4612502200950371664" "False" "High" "IsMasterProtein" "Q86V21" "Acetoacetyl-CoA synthetase OS=Homo sapiens OX=9606 GN=AACS PE=1 SV=1" "0.002" "False" "3.530" "2" "2" "2" "1" "672" "75.1" "6.24" "4.96" "2" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00501, Pf16177" "65985" "ENSG00000081760" "AACS" "hsa:65985; Q49AB9; Q49AC3; Q658Q8; Q86V21; Q8IWD2; Q8NEW5; Q9BSJ9; Q9H829; Q9HA19" "Synthesis of Ketone Bodies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2271404358644786379" "False" "High" "IsMasterProtein" "P46778" "Large ribosomal subunit protein eL21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2" "0.002" "False" "3.527" "9" "2" "2" "2" "160" "18.6" "10.49" "5.52" "2" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf01157" "6144" "ENSG00000122026" "RPL21" "hsa:6144; P46778; Q16699" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.931" "1.023" "1.025" "0.988" "1.036" "0.863" "0.937" "0.963" "1.245" "169.0" "157.3" "172.8" "173.3" "166.9" "175.1" "145.8" "158.4" "162.7" "210.4" "" "" "" "" "" "" "" "" "" "" "149.8" "130.3" "150.8" "129.6" "139.1" "160.8" "123.2" "130.9" "149.2" "210.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4172126226314731370" "False" "High" "IsMasterProtein" "Q9UGY1" "Nucleolar protein 12 OS=Homo sapiens OX=9606 GN=NOL12 PE=1 SV=1" "0.002" "False" "3.526" "7" "2" "3" "1" "213" "24.6" "10.23" "8.85" "2" "" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09805" "79159" "ENSG00000273899" "NOL12" "hsa:79159; Q9UGY1" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5487682516941207466" "False" "High" "IsMasterProtein" "P98171" "Rho GTPase-activating protein 4 OS=Homo sapiens OX=9606 GN=ARHGAP4 PE=1 SV=2" "0.002" "False" "3.522" "1" "1" "1" "1" "946" "105.0" "6.34" "2.35" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00611, Pf00620, Pf14604" "393" "ENSG00000089820" "ARHGAP4" "hsa:393; P98171; Q14144; Q86UY3" "RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "Clock-controlled autophagy in bone metabolism" "4" "0" "1.409" "1.105" "1.517" "1.228" "0.939" "1.113" "0.658" "1.145" "11.390" "47.3" "66.7" "52.3" "71.8" "58.1" "44.4" "52.7" "31.1" "54.2" "539.1" "" "" "" "" "" "" "" "" "" "" "42.0" "55.3" "45.6" "53.7" "48.5" "40.8" "44.5" "25.7" "49.7" "539.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2188123927045547815" "False" "High" "IsMasterProtein" "P51790" "H(+)/Cl(-) exchange transporter 3 OS=Homo sapiens OX=9606 GN=CLCN3 PE=1 SV=2" "0.002" "False" "3.506" "1" "1" "1" "1" "818" "90.9" "6.28" "3.66" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00571, Pf00654" "1182" "ENSG00000109572" "CLCN3" "B7Z932; B9EGJ9; D3DP34; E9PB97; hsa:1182; O14918; P51790; Q86Z21" "Stimuli-sensing channels" "TAR syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8429437180713985689" "False" "High" "IsMasterProtein" "Q13761" "Runt-related transcription factor 3 OS=Homo sapiens OX=9606 GN=RUNX3 PE=1 SV=2" "0.002" "False" "3.498" "4" "2" "2" "2" "415" "44.3" "9.47" "6.61" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "864" "ENSG00000020633" "RUNX3" "B1AJV5; hsa:864; Q12969; Q13760; Q13761" "Regulation of RUNX3 expression and activity; RUNX3 regulates BCL2L11 (BIM) transcription; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; RUNX3 regulates CDKN1A transcription; RUNX3 Regulates Immune Response and Cell Migration; RUNX3 regulates YAP1-mediated transcription; RUNX3 regulates NOTCH signaling; RUNX3 regulates RUNX1-mediated transcription" "TYROBP causal network in microglia; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "16" "0" "0.986" "0.862" "0.991" "0.895" "0.895" "0.961" "0.915" "0.842" "1.628" "219.2" "216.3" "188.9" "217.2" "196.3" "196.2" "210.6" "200.7" "184.5" "357.0" "" "" "" "" "" "" "" "" "" "" "194.4" "179.1" "164.8" "162.5" "163.7" "180.2" "178.0" "165.9" "169.2" "357.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7124655669919314751" "False" "High" "IsMasterProtein" "Q5T7V8" "RAB6-interacting golgin OS=Homo sapiens OX=9606 GN=GORAB PE=1 SV=2" "0.002" "False" "3.490" "2" "1" "1" "1" "369" "42.2" "6.48" "3.80" "1" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf04949" "92344" "ENSG00000120370" "GORAB" "hsa:92344; Q49A22; Q5T7V8; Q6P1P9; Q9HAE6; Q9Y350" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "575665869234459474" "False" "High" "IsMasterProtein" "P42331" "Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2" "0.002" "False" "3.479" "2" "2" "2" "2" "645" "73.4" "6.37" "5.33" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane" "enzyme regulator activity" "Pf00169, Pf00620" "9938" "ENSG00000163219" "ARHGAP25" "A8K2Y1; B7Z498; E9PFQ7; G5E9G2; hsa:9938; P42331; Q8IXQ2" "RAC1 GTPase cycle" "" "1" "0" "0.949" "0.811" "0.824" "0.839" "0.777" "0.835" "0.615" "0.799" "3.273" "398.6" "378.3" "323.2" "328.3" "334.6" "309.8" "332.9" "245.0" "318.6" "1304.6" "" "" "" "" "" "" "" "" "" "" "353.5" "313.3" "282.0" "245.6" "279.0" "284.6" "281.4" "202.5" "292.2" "1304.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501406145012788137" "False" "High" "IsMasterProtein" "Q9H2K0" "Translation initiation factor IF-3, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF3 PE=1 SV=4" "0.002" "False" "3.477" "3" "1" "1" "1" "278" "31.7" "9.69" "2.51" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf05198" "219402" "ENSG00000122033" "MTIF3" "hsa:219402; Q05BL8; Q5W0V0; Q86X68; Q9H2K0" "Mitochondrial translation initiation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1775190888259302728" "False" "High" "IsMasterProtein" "Q6P2C8" "Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens OX=9606 GN=MED27 PE=1 SV=1" "0.002" "False" "3.476" "3" "1" "1" "1" "311" "35.4" "9.31" "3.17" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf11571" "9442" "ENSG00000160563" "MED27" "hsa:9442; O95401; Q4F964; Q5VTA4; Q5VTA5; Q6P2C8; Q9BU57; Q9NYR4; V9GYV9" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3297038834745694354" "False" "High" "IsMasterProtein" "Q6N043" "Zinc finger protein 280D OS=Homo sapiens OX=9606 GN=ZNF280D PE=1 SV=3" "0.002" "False" "3.473" "1" "1" "1" "1" "979" "109.2" "8.19" "2.31" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13836" "54816" "ENSG00000137871" "ZNF280D" "A1L495; B2RMT6; hsa:54816; Q6MZM6; Q6N043; Q6N085; Q6P2R6; Q7Z6J5; Q9H0U5; Q9HCI8; Q9NXS0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8604308957137322217" "False" "High" "IsMasterProtein" "Q8IXQ5" "Kelch-like protein 7 OS=Homo sapiens OX=9606 GN=KLHL7 PE=1 SV=2" "0.002" "False" "3.463" "3" "2" "2" "2" "586" "65.9" "6.48" "5.71" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "55975" "ENSG00000122550" "KLHL7" "A4D144; B7Z5I9; G5E9G3; hsa:55975; Q7Z765; Q8IXQ5; Q96MV2; Q9BQF8; Q9UDQ9" "" "" "0" "0" "0.962" "0.806" "1.039" "1.058" "1.005" "1.043" "0.901" "0.908" "0.832" "94.4" "90.8" "76.1" "98.0" "99.8" "94.9" "98.4" "85.0" "85.7" "78.5" "" "" "" "" "" "" "" "" "" "" "83.7" "75.2" "66.4" "73.3" "83.2" "87.1" "83.2" "70.2" "78.6" "78.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1719078157177780013" "False" "High" "IsMasterProtein" "Q96DX7" "Tripartite motif-containing protein 44 OS=Homo sapiens OX=9606 GN=TRIM44 PE=1 SV=1" "0.002" "False" "3.463" "2" "1" "1" "1" "344" "38.4" "4.21" "1.94" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf00643" "54765" "ENSG00000166326" "TRIM44" "D3DR14; Q96DX7; Q96QY2; Q9UGK0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8458810131294421202" "False" "High" "IsMasterProtein" "Q96IK1" "Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens OX=9606 GN=BOD1 PE=1 SV=2" "0.002" "False" "3.452" "9" "2" "2" "1" "185" "19.2" "6.33" "4.49" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05205" "91272" "ENSG00000145919" "BOD1" "B4DXH8; hsa:91272; Q96IK1; Q9BTW1" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "0.919" "1.002" "0.902" "0.906" "0.953" "0.796" "0.891" "0.908" "0.503" "80.2" "73.7" "80.3" "72.4" "72.6" "76.4" "63.8" "71.4" "72.8" "40.3" "" "" "" "" "" "" "" "" "" "" "71.1" "61.1" "70.1" "54.1" "60.5" "70.2" "53.9" "59.0" "66.8" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4308852562196613776" "False" "High" "IsMasterProtein" "Q86UY6" "N-alpha-acetyltransferase 40 OS=Homo sapiens OX=9606 GN=NAA40 PE=1 SV=1" "0.002" "False" "3.451" "3" "1" "1" "1" "237" "27.2" "7.39" "3.23" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00583" "79829" "ENSG00000110583" "NAA40" "B4DR03; B4DU10; Q5HYL5; Q86UY6; Q9H897" "" "Metapathway biotransformation Phase I and II" "1" "0" "0.938" "0.737" "1.226" "1.026" "0.971" "1.074" "0.879" "0.935" "6.260" "31.4" "29.4" "23.1" "38.5" "32.2" "30.5" "33.7" "27.6" "29.4" "196.6" "" "" "" "" "" "" "" "" "" "" "27.9" "24.4" "20.2" "28.8" "26.9" "28.0" "28.5" "22.8" "26.9" "196.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7634397569492690707" "False" "High" "IsMasterProtein" "Q96HY7" "2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2" "0.002" "False" "3.448" "2" "2" "2" "2" "919" "103.0" "6.93" "5.80" "2" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00676, Pf02779, Pf16870" "55526" "ENSG00000181192" "DHTKD1" "hsa:55526; Q68CU5; Q96HY7; Q9BUM8; Q9HCE2" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5201003566343787009" "False" "High" "IsMasterProtein" "P62273" "Small ribosomal subunit protein uS14 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2" "0.002" "False" "3.448" "23" "2" "2" "2" "56" "6.7" "10.13" "5.18" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00253" "6235" "ENSG00000213741" "RPS29" "A8MZ73; hsa:6235; P30054; P62273" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.017" "1.048" "1.017" "1.123" "1.079" "0.936" "1.145" "0.968" "0.959" "62.4" "63.5" "65.4" "63.5" "70.1" "67.4" "58.4" "71.5" "60.4" "59.9" "" "" "" "" "" "" "" "" "" "" "55.4" "52.6" "57.1" "47.5" "58.5" "61.9" "49.4" "59.1" "55.4" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3780943028693763467" "False" "High" "IsMasterProtein" "Q9H009" "Nascent polypeptide-associated complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=NACA2 PE=1 SV=1" "0.002" "False" "3.447" "4" "1" "1" "1" "215" "23.2" "4.73" "4.14" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf01849, Pf19026" "342538" "ENSG00000253506" "NACA2" "hsa:342538; Q2VIR9; Q9H009" "" "" "0" "0" "0.930" "0.947" "1.011" "0.751" "1.274" "1.065" "1.000" "0.882" "0.734" "210.4" "195.6" "199.2" "212.6" "158.0" "268.0" "224.1" "210.4" "185.6" "154.3" "" "" "" "" "" "" "" "" "" "" "186.6" "162.0" "173.8" "159.0" "131.7" "246.2" "189.4" "173.9" "170.2" "154.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234172936871541887" "False" "High" "IsMasterProtein" "Q9HA65" "TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=3" "0.002" "False" "3.445" "1" "1" "1" "1" "648" "72.6" "5.21" "3.75" "1" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00566, Pf12068" "79735" "ENSG00000104946" "TBC1D17" "B4DT12; B9A6L8; F5H1W7; hsa:79735; Q9HA65" "TBC/RABGAPs" "" "1" "0" "0.988" "0.930" "0.958" "0.966" "0.928" "0.953" "0.838" "0.982" "3.021" "229.8" "227.0" "213.8" "220.2" "222.1" "213.2" "219.1" "192.5" "225.8" "694.1" "" "" "" "" "" "" "" "" "" "" "203.8" "188.1" "186.5" "164.7" "185.2" "195.8" "185.2" "159.1" "207.1" "694.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9151780766463194199" "False" "High" "IsMasterProtein" "P24863" "Cyclin-C OS=Homo sapiens OX=9606 GN=CCNC PE=1 SV=2" "0.002" "False" "3.444" "4" "1" "1" "1" "283" "33.2" "7.33" "3.66" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf16899" "892" "ENSG00000112237" "CCNC" "B4DPZ1; hsa:892; P24863; Q9H543" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH1 Intracellular Domain Regulates Transcription" "Vitamin D receptor pathway" "9" "0" "1.008" "0.917" "1.089" "1.005" "0.867" "1.026" "1.006" "0.926" "0.806" "180.6" "182.2" "165.7" "196.7" "181.6" "156.5" "185.4" "181.7" "167.3" "145.6" "" "" "" "" "" "" "" "" "" "" "160.2" "150.9" "144.6" "147.1" "151.4" "143.8" "156.7" "150.2" "153.5" "145.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991107467839093977" "False" "High" "IsMasterProtein" "Q99747" "Gamma-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPG PE=1 SV=1" "0.002" "False" "3.439" "3" "1" "2" "1" "312" "34.7" "5.41" "4.89" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf14938" "8774" "ENSG00000134265" "NAPG" "B4DFC9; hsa:8774; Q99747; Q9BUV1" "Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; Intra-Golgi traffic" "" "5" "0" "1.236" "1.168" "1.277" "0.977" "1.099" "1.303" "0.719" "1.173" "10.033" "41.5" "51.2" "48.4" "53.0" "40.5" "45.6" "54.0" "29.8" "48.7" "416.0" "" "" "" "" "" "" "" "" "" "" "36.8" "42.4" "42.2" "39.6" "33.8" "41.9" "45.7" "24.7" "44.6" "416.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "997292728151378108" "False" "High" "IsMasterProtein" "P32519" "ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2" "0.002" "False" "3.438" "3" "2" "2" "2" "619" "67.5" "5.21" "5.72" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1997" "ENSG00000120690" "ELF1" "B4E2I5; E9PDQ9; hsa:1997; P32519; Q8N6F6; Q9UDE1" "RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling" "" "2" "0" "1.007" "0.901" "0.942" "0.886" "0.976" "0.743" "0.491" "0.796" "7.625" "162.5" "163.6" "146.3" "153.1" "143.9" "158.5" "120.6" "79.7" "129.3" "1238.6" "" "" "" "" "" "" "" "" "" "" "144.1" "135.5" "127.7" "114.5" "120.0" "145.6" "102.0" "65.9" "118.6" "1238.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "High" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.003" "False" "3.424" "3" "2" "2" "2" "832" "94.3" "6.70" "5.68" "2" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1322674044200343444" "False" "High" "IsMasterProtein" "Q12789" "General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4" "0.003" "False" "3.420" "0" "1" "1" "1" "2109" "238.7" "7.30" "4.27" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04182" "2975" "ENSG00000077235" "GTF3C1" "B2RP21; hsa:2975; Q12789; Q12838; Q6DKN9; Q9Y4W9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595761277015332679" "False" "High" "IsMasterProtein" "Q5TA50" "Ceramide-1-phosphate transfer protein OS=Homo sapiens OX=9606 GN=CPTP PE=1 SV=1" "0.003" "False" "3.405" "4" "1" "1" "1" "214" "24.4" "7.21" "2.81" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf08718" "80772" "ENSG00000224051" "CPTP" "hsa:80772; Q4G0E6; Q5TA50; Q7L5A4" "Glycosphingolipid transport" "1p36 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5520815567594939370" "False" "High" "IsMasterProtein" "O43257" "Zinc finger HIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT1 PE=1 SV=1" "0.003" "False" "3.400" "6" "1" "1" "1" "154" "17.5" "9.41" "3.95" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "10467" "ENSG00000106400" "ZNHIT1" "hsa:10467; O43257; Q6IB12" "" "" "0" "0" "0.748" "0.858" "0.849" "0.750" "0.844" "0.755" "0.700" "0.776" "1.808" "100.4" "75.1" "86.1" "85.2" "75.3" "84.7" "75.8" "70.3" "78.0" "181.6" "" "" "" "" "" "" "" "" "" "" "89.1" "62.2" "75.2" "63.8" "62.8" "77.8" "64.1" "58.1" "71.5" "181.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5044889676122240904" "False" "High" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "0.003" "False" "3.398" "1" "2" "2" "2" "941" "107.8" "7.05" "5.44" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "SARS-CoV-2 modulates autophagy" "Network map of SARS-CoV-2 signaling pathway" "2" "0" "1.013" "1.375" "0.696" "0.870" "1.001" "1.166" "0.794" "1.810" "10.816" "27.9" "28.3" "38.4" "19.4" "24.3" "28.0" "32.6" "22.2" "50.5" "302.0" "" "" "" "" "" "" "" "" "" "" "24.8" "23.4" "33.5" "14.5" "20.2" "25.7" "27.5" "18.3" "46.3" "302.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4034364937765710536" "False" "High" "IsMasterProtein" "Q9UPV0" "Centrosomal protein of 164 kDa OS=Homo sapiens OX=9606 GN=CEP164 PE=1 SV=3" "0.003" "False" "3.398" "1" "1" "1" "1" "1460" "164.2" "5.36" "2.23" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "" "22897" "ENSG00000110274" "CEP164" "hsa:22897; Q6PKH9; Q7Z2X9; Q9NVS0; Q9UFJ6; Q9UPV0" "Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.003" "False" "3.385" "9" "1" "1" "1" "99" "11.2" "4.88" "3.54" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "Kleefstra syndrome" "5" "0" "0.912" "1.039" "0.985" "0.945" "0.988" "0.971" "1.030" "1.015" "0.874" "109.4" "99.8" "113.6" "107.8" "103.4" "108.1" "106.2" "112.7" "111.0" "95.6" "" "" "" "" "" "" "" "" "" "" "97.0" "82.7" "99.2" "80.6" "86.3" "99.3" "89.8" "93.2" "101.8" "95.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5340493121731341937" "False" "High" "IsMasterProtein" "Q9BQD3" "KxDL motif-containing protein 1 OS=Homo sapiens OX=9606 GN=KXD1 PE=1 SV=2" "0.003" "False" "3.380" "6" "1" "1" "1" "176" "19.7" "4.89" "2.32" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10241" "79036" "ENSG00000105700" "KXD1" "O76098; Q9BQD3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8114492968310580525" "False" "High" "IsMasterProtein" "P98194" "Calcium-transporting ATPase type 2C member 1 OS=Homo sapiens OX=9606 GN=ATP2C1 PE=1 SV=3" "0.003" "False" "3.377" "1" "1" "1" "1" "919" "100.5" "6.74" "3.65" "1" "cell adhesion;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "27032" "ENSG00000017260" "ATP2C1" "B2RAT7; B4DSW3; B7Z3X9; G3XAH8; G8JLN9; hsa:27032; O76005; P98194; Q86V72; Q86V73; Q8N6V1; Q8NCJ7" "Ion transport by P-type ATPases" "" "1" "0" "0.994" "0.987" "0.952" "0.993" "1.129" "0.986" "1.060" "1.098" "1.149" "245.4" "243.9" "242.1" "233.6" "243.5" "276.9" "241.9" "260.2" "269.5" "282.0" "" "" "" "" "" "" "" "" "" "" "217.6" "202.1" "211.3" "174.7" "203.1" "254.4" "204.4" "215.0" "247.1" "282.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2072306986524889695" "False" "High" "IsMasterProtein" "Q8WVD3" "E3 ubiquitin-protein ligase RNF138 OS=Homo sapiens OX=9606 GN=RNF138 PE=1 SV=1" "0.003" "False" "3.377" "4" "1" "1" "1" "245" "28.2" "6.93" "3.91" "1" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05605, Pf13923, Pf18574" "51444" "ENSG00000134758" "RNF138" "B2RE17; hsa:51444; Q8WVD3; Q9H8K2; Q9UF87; Q9UKI6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6803105277320929101" "False" "High" "IsMasterProtein" "Q99848" "Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2" "0.003" "False" "3.375" "3" "1" "1" "1" "306" "34.8" "10.10" "2.76" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf05890" "10969" "ENSG00000117395" "EBNA1BP2" "hsa:10969; Q96A66; Q99848" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8923754017779297003" "False" "High" "IsMasterProtein" "Q9H6A0" "DENN domain-containing protein 2D OS=Homo sapiens OX=9606 GN=DENND2D PE=1 SV=2" "0.003" "False" "3.374" "2" "1" "1" "1" "471" "53.6" "7.64" "4.07" "1" "" "cytosol;nucleus" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "79961" "ENSG00000162777" "DENND2D" "hsa:79961; Q5T5V6; Q9BSU0; Q9H6A0" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5703781762481200822" "False" "High" "IsMasterProtein" "Q04941" "Proteolipid protein 2 OS=Homo sapiens OX=9606 GN=PLP2 PE=1 SV=1" "0.003" "False" "3.370" "9" "1" "1" "1" "152" "16.7" "7.24" "3.20" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf01284" "5355" "ENSG00000102007" "PLP2" "A6NDT7; hsa:5355; Q04941; Q32MM8" "" "" "0" "0" "0.856" "0.789" "0.792" "0.956" "0.855" "0.827" "0.837" "0.842" "0.806" "98.8" "84.6" "78.0" "78.2" "94.4" "84.5" "81.7" "82.7" "83.2" "79.6" "" "" "" "" "" "" "" "" "" "" "87.6" "70.0" "68.0" "58.5" "78.7" "77.6" "69.1" "68.4" "76.3" "79.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5102394332226681343" "False" "High" "IsMasterProtein" "Q05932" "Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3" "0.003" "False" "3.368" "2" "1" "1" "1" "587" "64.6" "7.94" "3.79" "1" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "" "2356" "ENSG00000136877" "FPGS" "B3KPW4; B7Z2Z3; F5H0K6; hsa:2356; Q05932; Q5JU19; Q5JU22; Q6P2P6" "" "Fluoropyrimidine activity" "1" "0" "1.031" "1.018" "0.816" "1.007" "0.898" "0.749" "0.633" "1.030" "4.329" "70.0" "72.1" "71.2" "57.1" "70.4" "62.8" "52.4" "44.3" "72.1" "302.9" "" "" "" "" "" "" "" "" "" "" "62.0" "59.8" "62.1" "42.7" "58.7" "57.7" "44.3" "36.6" "66.1" "302.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5519015022968038253" "False" "High" "IsMasterProtein" "Q86X10" "Ral GTPase-activating protein subunit beta OS=Homo sapiens OX=9606 GN=RALGAPB PE=1 SV=1" "0.003" "False" "3.366" "1" "1" "1" "1" "1494" "166.7" "6.79" "2.88" "1" "other biological processes" "" "enzyme regulator activity;other molecular function" "Pf20412" "57148" "ENSG00000170471" "RALGAPB" "A2A2E8; A2A2E9; hsa:57148; Q5TG31; Q86X10; Q8N3D1; Q8WWC0; Q9H3X8; Q9UJR1; Q9ULK1; Q9Y3G9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1906728962657119093" "False" "High" "IsMasterProtein" "Q13077" "TNF receptor-associated factor 1 OS=Homo sapiens OX=9606 GN=TRAF1 PE=1 SV=1" "0.003" "False" "3.363" "2" "1" "1" "1" "416" "46.1" "6.11" "3.92" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16673, Pf21355" "7185" "ENSG00000056558" "TRAF1" "B4DJ77; hsa:7185; Q13077; Q658U1; Q8NF13" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Oxidative damage response; Small cell lung cancer; IL-18 signaling pathway; 16p11.2 distal deletion syndrome; Genes associated with the development of rheumatoid arthritis; 13q12.12 copy number variation" "14" "0" "1.100" "1.073" "1.127" "1.113" "1.209" "0.973" "1.045" "1.073" "0.689" "148.7" "163.6" "159.6" "167.7" "165.5" "179.8" "144.6" "155.3" "159.6" "102.5" "" "" "" "" "" "" "" "" "" "" "131.9" "135.5" "139.2" "125.4" "138.0" "165.1" "122.2" "128.4" "146.4" "102.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337751321720822318" "False" "High" "IsMasterProtein" "O76074" "cGMP-specific 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE5A PE=1 SV=2" "0.003" "False" "3.362" "1" "1" "1" "1" "875" "99.9" "6.09" "3.66" "1" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "cytosol" "other molecular function" "Pf00233, Pf01590" "8654" "ENSG00000138735" "PDE5A" "A0AV69; A8K2C4; hsa:8654; O75026; O75887; O76074; Q86UI0; Q86V66; Q9Y6Z6" "cGMP effects; Smooth Muscle Contraction; RHOBTB1 GTPase cycle" "Phosphodiesterases in neuronal function; Sildenafil treatment" "5" "0" "1.106" "0.944" "0.917" "0.953" "0.932" "0.943" "1.016" "0.916" "0.660" "69.7" "77.1" "65.8" "63.9" "66.4" "65.0" "65.7" "70.8" "63.8" "46.0" "" "" "" "" "" "" "" "" "" "" "61.8" "63.8" "57.4" "47.8" "55.4" "59.7" "55.6" "58.5" "58.5" "46.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8448471456180421378" "False" "High" "IsMasterProtein" "Q9P275" "Ubiquitin carboxyl-terminal hydrolase 36 OS=Homo sapiens OX=9606 GN=USP36 PE=1 SV=4" "0.003" "False" "3.357" "2" "2" "2" "2" "1123" "122.8" "9.70" "5.69" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57602" "ENSG00000055483" "USP36" "hsa:57602; Q05C98; Q05DD0; Q6IQ38; Q8NDM8; Q9NVC8; Q9P275" "" "" "0" "0" "1.051" "1.044" "1.196" "0.998" "0.952" "0.924" "0.902" "1.047" "0.693" "120.6" "126.8" "126.0" "144.3" "120.4" "114.9" "111.5" "108.8" "126.3" "83.6" "" "" "" "" "" "" "" "" "" "" "107.0" "105.0" "109.9" "107.9" "100.4" "105.5" "94.2" "89.9" "115.8" "83.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "High" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.003" "False" "3.350" "3" "1" "1" "1" "329" "36.1" "5.69" "2.53" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2435225049251902172" "False" "High" "IsMasterProtein" "Q8NEY8" "Periphilin-1 OS=Homo sapiens OX=9606 GN=PPHLN1 PE=1 SV=2" "0.003" "False" "3.342" "2" "1" "2" "1" "458" "52.7" "9.11" "3.20" "1" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf11488" "51535" "ENSG00000134283" "PPHLN1" "E9PAX8; hsa:51535; Q86YT2; Q8IXN3; Q8NEY8; Q8TB09; Q96NB9; Q9NXL4; Q9P0P6; Q9P0R9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009028340265945261" "False" "High" "IsMasterProtein" "Q5QJE6" "Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Homo sapiens OX=9606 GN=DNTTIP2 PE=1 SV=2" "0.003" "False" "3.331" "2" "1" "1" "1" "756" "84.4" "6.16" "2.30" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf08698" "30836" "ENSG00000067334" "DNTTIP2" "hsa:30836; Q12987; Q53H59; Q5QJE6; Q5TFJ4; Q6TLI0; Q76MJ8; Q86WX9" "" "" "0" "0" "1.230" "0.826" "1.251" "1.075" "0.962" "1.102" "1.113" "0.984" "0.415" "162.0" "199.3" "133.8" "202.6" "174.2" "155.9" "178.6" "180.3" "159.4" "67.3" "" "" "" "" "" "" "" "" "" "" "143.7" "165.1" "116.7" "151.5" "145.3" "143.2" "150.9" "149.0" "146.2" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2762375354567501212" "False" "High" "IsMasterProtein" "Q9UI14" "Prenylated Rab acceptor protein 1 OS=Homo sapiens OX=9606 GN=RABAC1 PE=1 SV=1" "0.003" "False" "3.330" "8" "2" "3" "2" "185" "20.6" "7.34" "6.95" "2" "" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf03208" "10567" "ENSG00000105404" "RABAC1" "hsa:10567; Q7Z4Y2; Q9UI14; Q9Y3R1" "" "Intracellular trafficking proteins involved in CMT neuropathy" "1" "0" "1.032" "0.954" "1.224" "1.121" "0.998" "1.190" "1.102" "0.922" "1.002" "100.6" "103.8" "95.9" "123.0" "112.7" "100.4" "119.7" "110.8" "92.7" "100.7" "" "" "" "" "" "" "" "" "" "" "89.2" "86.0" "83.7" "92.0" "94.0" "92.2" "101.1" "91.6" "85.0" "100.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6242890484097416684" "False" "High" "IsMasterProtein" "Q05707" "Collagen alpha-1(XIV) chain OS=Homo sapiens OX=9606 GN=COL14A1 PE=1 SV=3" "0.003" "False" "3.329" "1" "1" "1" "1" "1796" "193.4" "5.30" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "extracellular matrix;ER/Golgi;other cell component" "extracellular structural activity;other molecular function" "Pf00041, Pf00092, Pf01391" "7373" "ENSG00000187955" "COL14A1" "B2RU07; hsa:7373; O00260; O00261; O00262; Q05707; Q05708; Q5XJ18; Q96C67; Q9UDF6" "Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization" "" "4" "0" "1.042" "0.645" "1.323" "0.868" "0.612" "1.149" "0.754" "0.616" "0.437" "167.2" "174.3" "107.8" "221.2" "145.2" "102.3" "192.2" "126.1" "103.0" "73.1" "" "" "" "" "" "" "" "" "" "" "148.3" "144.4" "94.1" "165.5" "121.1" "94.0" "162.4" "104.2" "94.4" "73.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6429829265109065011" "False" "High" "IsMasterProtein" "Q63HR2" "Tensin-2 OS=Homo sapiens OX=9606 GN=TNS2 PE=1 SV=2" "0.003" "False" "3.326" "1" "1" "1" "1" "1409" "152.5" "8.35" "2.14" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00017, Pf00130, Pf08416, Pf10409" "23371" "ENSG00000111077" "TNS2" "A2VDF2; A2VDF3; A2VDI8; A5PKY4; hsa:23371; Q2NL80; Q63HR2; Q76MW6; Q7Z5T9; Q8NFF9; Q8NFG0; Q96P25; Q9NT29; Q9UPS7" "" "" "0" "0" "1.059" "0.980" "0.963" "0.875" "0.997" "1.077" "1.015" "0.991" "1.006" "104.5" "110.7" "102.4" "100.7" "91.5" "104.3" "112.6" "106.1" "103.6" "105.2" "" "" "" "" "" "" "" "" "" "" "92.7" "91.7" "89.4" "75.3" "76.3" "95.8" "95.1" "87.7" "95.0" "105.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1985122715362872107" "False" "High" "IsMasterProtein" "Q6PKC3" "Thioredoxin domain-containing protein 11 OS=Homo sapiens OX=9606 GN=TXNDC11 PE=1 SV=2" "0.003" "False" "3.325" "1" "1" "1" "1" "985" "110.5" "6.55" "3.04" "1" "" "other membranes;ER/Golgi" "" "Pf00085" "51061" "ENSG00000153066" "TXNDC11" "hsa:51061; O95887; Q6PJA6; Q6PKC3; Q8N2Q4; Q96K45; Q96K53" "" "" "0" "0" "1.233" "1.029" "1.055" "1.028" "1.072" "1.255" "1.133" "0.879" "0.851" "129.3" "159.5" "133.0" "136.4" "133.0" "138.5" "162.3" "146.5" "113.6" "110.0" "" "" "" "" "" "" "" "" "" "" "114.7" "132.1" "116.1" "102.0" "110.9" "127.3" "137.1" "121.1" "104.2" "110.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7428789248326489626" "False" "High" "IsMasterProtein" "O00712" "Nuclear factor 1 B-type OS=Homo sapiens OX=9606 GN=NFIB PE=1 SV=2" "0.003" "False" "3.323" "5" "2" "2" "2" "420" "47.4" "8.87" "5.44" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4781" "ENSG00000147862" "NFIB" "G3V1P1; H7BYE8; hsa:4781; O00166; O00712; Q12858; Q5VW29; Q63HM5; Q6ZNF9; Q96J45" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "Pathways affected in adenoid cystic carcinoma" "3" "0" "1.051" "0.906" "1.096" "0.974" "1.061" "1.005" "0.983" "1.214" "1.207" "109.6" "115.2" "99.3" "120.1" "106.7" "116.2" "110.1" "107.7" "133.0" "132.3" "" "" "" "" "" "" "" "" "" "" "97.2" "95.4" "86.6" "89.8" "89.0" "106.8" "93.1" "89.0" "122.0" "132.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1272084248319891202" "False" "High" "IsMasterProtein" "Q9UKB1" "F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1" "0.003" "False" "3.315" "2" "1" "1" "1" "542" "62.1" "7.12" "3.44" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf12125, Pf12937" "23291" "ENSG00000072803" "FBXW11" "B2RC98; hsa:23291; Q9P2S8; Q9P2S9; Q9UKB1; Q9Y4C6" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Regulation of PLK1 Activity at G2/M Transition; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "TNF-alpha signaling pathway; VEGFA-VEGFR2 signaling" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1537630137721928118" "False" "High" "IsMasterProtein" "Q8IU60" "m7GpppN-mRNA hydrolase OS=Homo sapiens OX=9606 GN=DCP2 PE=1 SV=3" "0.003" "False" "3.313" "2" "1" "1" "1" "420" "48.4" "8.00" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293, Pf05026" "167227" "ENSG00000172795" "DCP2" "C9J778; hsa:167227; Q6P2D4; Q7Z5W5; Q8IU60; Q8NBG5" "mRNA decay by 5' to 3' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65885547714639477" "False" "High" "IsMasterProtein" "O60308" "Centrosomal protein of 104 kDa OS=Homo sapiens OX=9606 GN=CEP104 PE=1 SV=1" "0.003" "False" "3.307" "2" "2" "3" "1" "925" "104.4" "7.62" "6.64" "2" "" "cytoskeleton;other cell component" "" "Pf21038, Pf21039" "9731" "ENSG00000116198" "CEP104" "A0A024R4G3; hsa:9731; O60308; Q5JSQ3; Q5SR24; Q5SR25; Q6PKF5; Q86W32; Q86X14" "" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7892185460647837485" "False" "High" "IsMasterProtein" "Q53RE8" "Ankyrin repeat domain-containing protein 39 OS=Homo sapiens OX=9606 GN=ANKRD39 PE=1 SV=1" "0.003" "False" "3.303" "6" "1" "1" "1" "183" "19.6" "6.89" "3.71" "1" "" "" "" "Pf12796" "51239" "ENSG00000213337" "ANKRD39" "hsa:51239; Q53RE8; Q59FU2; Q8N5X5; Q9P0S5" "" "2q11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7444936349459715889" "False" "High" "IsMasterProtein" "Q32P28" "Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2" "0.003" "False" "3.302" "1" "1" "1" "1" "736" "83.3" "5.14" "3.56" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13640" "64175" "ENSG00000117385" "P3H1" "hsa:64175; Q32P28; Q7KZR4; Q96BR8; Q96SK8; Q96SL5; Q96SN3; Q9H6K3; Q9HC86; Q9HC87" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6924656061698190740" "False" "High" "IsMasterProtein" "Cont_Q2UVX4" "Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2" "0.003" "True" "3.301" "1" "1" "1" "1" "1661" "187.1" "6.84" "3.56" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17790, Pf17791, Pf21308, Pf21406" "280677" "ENSBTAG00000017280" "C3" "bta:280677; Q2KIZ4; Q2UVX4" "Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5" "Complement and coagulation cascades; Complement activation, classical pathway" "11" "0" "1.056" "1.066" "0.925" "1.296" "0.794" "0.972" "1.122" "1.055" "0.494" "51.5" "54.4" "54.9" "47.6" "66.7" "40.9" "50.1" "57.7" "54.3" "25.4" "" "" "" "" "" "" "" "" "" "" "45.7" "45.1" "47.9" "35.6" "55.6" "37.5" "42.3" "47.7" "49.8" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1455362657326634232" "False" "High" "IsMasterProtein" "Q02543" "Large ribosomal subunit protein eL20 OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2" "0.003" "False" "3.297" "5" "1" "1" "1" "176" "20.7" "10.71" "3.69" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01775" "6142" "ENSG00000105640" "RPL18A" "hsa:6142; Q02543" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4561933771637395336" "False" "High" "IsMasterProtein" "Q15329" "Transcription factor E2F5 OS=Homo sapiens OX=9606 GN=E2F5 PE=1 SV=1" "0.003" "False" "3.287" "5" "1" "2" "1" "346" "37.6" "5.10" "5.76" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1875" "ENSG00000133740" "E2F5" "E9PBN9; hsa:1875; Q15329; Q16601; Q92756" "G1/S-Specific Transcription; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Cyclin D associated events in G1; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Spinal cord injury; Pre-implantation embryo; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7972073683050353884" "False" "High" "IsMasterProtein" "Q9NYP3" "Protein downstream neighbor of Son OS=Homo sapiens OX=9606 GN=DONSON PE=1 SV=2" "0.003" "False" "3.277" "2" "1" "1" "1" "566" "62.7" "8.66" "0.00" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction" "nucleus;other cell component" "" "" "29980" "ENSG00000159147" "DONSON" "hsa:29980; Q8NC53; Q9NSR9; Q9NVZ5; Q9NYP1; Q9NYP2; Q9NYP3" "" "" "0" "0" "1.072" "1.464" "1.395" "1.689" "1.373" "1.525" "1.310" "1.169" "1.219" "16.3" "17.5" "23.9" "22.7" "27.5" "22.4" "24.9" "21.4" "19.0" "19.9" "" "" "" "" "" "" "" "" "" "" "14.5" "14.5" "20.8" "17.0" "23.0" "20.6" "21.0" "17.6" "17.5" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5750940690254382676" "False" "High" "IsMasterProtein" "P16333" "SH2/SH3 adapter protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1" "0.003" "False" "3.271" "2" "1" "1" "1" "377" "42.8" "6.47" "3.54" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "4690" "ENSG00000158092" "NCK1" "B7Z751; D3DNE3; hsa:4690; P16333" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; RHO GTPases Activate WASPs and WAVEs; PKR-mediated signaling; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; DCC mediated attractive signaling; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Activation of RAC1" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; GDNF signaling; ErbB signaling pathway; T-cell receptor signaling pathway" "27" "0" "1.045" "0.917" "1.104" "0.973" "0.943" "1.148" "0.575" "0.856" "7.098" "181.0" "189.2" "166.0" "199.8" "176.1" "170.7" "207.8" "104.2" "155.0" "1284.8" "" "" "" "" "" "" "" "" "" "" "160.5" "156.7" "144.9" "149.5" "146.8" "156.8" "175.6" "86.1" "142.2" "1284.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1155650016836113983" "False" "High" "IsMasterProtein" "Q6NYC1" "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1" "0.003" "False" "3.268" "2" "1" "1" "1" "403" "46.4" "8.69" "3.50" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "23210" "ENSG00000070495" "JMJD6" "B3KMN8; B4DGX1; hsa:23210; Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2" "Protein hydroxylation; HDMs demethylate histones" "" "2" "0" "0.995" "0.888" "0.936" "0.930" "0.762" "0.846" "0.613" "0.811" "4.818" "119.0" "118.3" "105.7" "111.3" "110.6" "90.6" "100.6" "72.9" "96.5" "573.3" "" "" "" "" "" "" "" "" "" "" "105.5" "98.0" "92.2" "83.3" "92.2" "83.3" "85.1" "60.3" "88.5" "573.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7643769137675685694" "False" "High" "IsMasterProtein" "P82933" "Small ribosomal subunit protein uS9m OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" "0.003" "False" "3.260" "4" "2" "2" "2" "396" "45.8" "9.51" "5.41" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00380" "64965" "ENSG00000135972" "MRPS9" "hsa:64965; P82933; Q6PG40" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9126383945873121756" "False" "High" "IsMasterProtein" "A5PKW4" "PH and SEC7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PSD PE=1 SV=2" "0.003" "False" "3.258" "2" "2" "2" "2" "1024" "109.5" "6.87" "4.80" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "5662" "ENSG00000059915" "PSD" "A5PKW4; B1AKX7; D3DR87; hsa:5662; Q15673; Q8IVG0" "" "" "0" "0" "0.851" "0.762" "0.788" "0.772" "0.847" "0.793" "0.726" "0.700" "0.522" "357.7" "304.5" "272.5" "281.8" "276.3" "303.1" "283.7" "259.7" "250.6" "186.8" "" "" "" "" "" "" "" "" "" "" "317.2" "252.2" "237.8" "210.7" "230.4" "278.4" "239.8" "214.7" "229.8" "186.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365521486549272318" "False" "High" "IsMasterProtein" "Q6ICB0" "Desumoylating isopeptidase 1 OS=Homo sapiens OX=9606 GN=DESI1 PE=1 SV=1" "0.003" "False" "3.258" "5" "1" "1" "1" "168" "18.3" "4.94" "2.95" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05903" "27351" "ENSG00000100418" "DESI1" "hsa:27351; Q6ICB0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4920792406220343653" "False" "High" "IsMasterProtein" "Q8NBM8" "Prenylcysteine oxidase-like OS=Homo sapiens OX=9606 GN=PCYOX1L PE=1 SV=2" "0.003" "False" "3.243" "2" "1" "1" "1" "494" "54.6" "7.31" "3.46" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;other cell component" "other molecular function" "Pf07156, Pf13450" "78991" "ENSG00000145882" "PCYOX1L" "hsa:78991; Q7Z4S2; Q8NBM8; Q8NCY5; Q8NF69; Q9BTE8; Q9BWS3" "Platelet degranulation" "" "1" "0" "1.090" "0.972" "1.118" "1.059" "0.983" "1.252" "1.021" "1.052" "0.725" "192.1" "209.5" "186.7" "214.7" "203.4" "188.9" "240.5" "196.2" "202.1" "139.2" "" "" "" "" "" "" "" "" "" "" "170.4" "173.5" "162.9" "160.6" "169.6" "173.5" "203.2" "162.1" "185.4" "139.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3729688095668830132" "False" "High" "IsMasterProtein" "O75419" "Cell division control protein 45 homolog OS=Homo sapiens OX=9606 GN=CDC45 PE=1 SV=1" "0.003" "False" "3.242" "4" "2" "2" "2" "566" "65.5" "5.53" "3.19" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02724" "8318" "ENSG00000093009" "CDC45" "B4DDB4; B4DDU3; E9PDH7; hsa:8318; O60856; O75419; Q20WK8; Q6UW54; Q9UP68" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription" "Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8194889804076803831" "False" "High" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "0.003" "False" "3.239" "1" "1" "2" "1" "619" "70.1" "8.51" "2.46" "1" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "mRNA processing" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502793154652310480" "False" "High" "IsMasterProtein" "O15240" "Neurosecretory protein VGF OS=Homo sapiens OX=9606 GN=VGF PE=1 SV=2" "0.003" "False" "3.235" "1" "1" "1" "1" "615" "67.2" "4.78" "3.60" "1" "cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "" "7425" "ENSG00000128564" "VGF" "hsa:7425; O15240; Q9UDW8" "NGF-stimulated transcription; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "3" "0" "0.807" "0.843" "1.016" "0.754" "0.681" "0.891" "1.017" "1.004" "0.800" "94.2" "76.0" "79.4" "95.7" "71.0" "64.1" "83.9" "95.8" "94.6" "75.4" "" "" "" "" "" "" "" "" "" "" "83.5" "62.9" "69.3" "71.6" "59.2" "58.9" "70.9" "79.2" "86.7" "75.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2185607745939655049" "False" "High" "IsMasterProtein" "P19532" "Transcription factor E3 OS=Homo sapiens OX=9606 GN=TFE3 PE=1 SV=4" "0.003" "False" "3.234" "3" "2" "2" "1" "575" "61.5" "5.58" "5.93" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7030" "ENSG00000068323; ENSG00000292217" "TFE3" "A8MZL6; hsa:7030; P19532; Q5JU74; Q92757; Q92758; Q99964" "" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Autophagy in pancreatic ductal adenocarcinoma; TGF-beta receptor signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7975170816643306332" "False" "High" "IsMasterProtein" "O43543" "DNA repair protein XRCC2 OS=Homo sapiens OX=9606 GN=XRCC2 PE=1 SV=1" "0.003" "False" "3.232" "4" "1" "1" "1" "280" "31.9" "6.04" "2.98" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7516" "ENSG00000196584" "XRCC2" "B2R925; hsa:7516; O43543" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "Male infertility; Primary ovarian insufficiency" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-332338773626550486" "False" "High" "IsMasterProtein" "Q9BQI3" "Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Homo sapiens OX=9606 GN=EIF2AK1 PE=1 SV=2" "0.003" "False" "3.230" "1" "1" "1" "1" "630" "71.1" "5.99" "2.45" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "27102" "ENSG00000086232" "EIF2AK1" "A8K2R2; hsa:27102; Q549K6; Q8NBW3; Q9BQI3; Q9HC02; Q9NYE0; Q9P0V6; Q9P1J5; Q9P2H8; Q9UHG4" "Response of EIF2AK1 (HRI) to heme deficiency; Cellular response to mitochondrial stress" "Translation factors; Measles virus infection" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3392290766648390097" "False" "High" "IsMasterProtein" "Q9UPP1" "Histone lysine demethylase PHF8 OS=Homo sapiens OX=9606 GN=PHF8 PE=1 SV=3" "0.003" "False" "3.230" "1" "1" "1" "1" "1060" "117.8" "8.72" "4.31" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf00628, Pf02373, Pf17811" "23133" "ENSG00000172943" "PHF8" "B3KMV4; B7Z911; hsa:23133; Q5H9U5; Q5JPR9; Q5JPS0; Q5JPS2; Q5JPS3; Q5VUJ4; Q7Z6D4; Q9HAH2; Q9UPP1" "HDMs demethylate histones" "Ectoderm differentiation" "2" "0" "1.199" "1.168" "0.723" "0.865" "1.060" "0.941" "0.689" "0.981" "2.327" "50.6" "60.6" "59.1" "36.6" "43.7" "53.6" "47.6" "34.8" "49.6" "117.7" "" "" "" "" "" "" "" "" "" "" "44.8" "50.2" "51.5" "27.4" "36.5" "49.2" "40.2" "28.8" "45.5" "117.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3451981213719268513" "False" "High" "IsMasterProtein" "Q9Y5Y6" "Suppressor of tumorigenicity 14 protein OS=Homo sapiens OX=9606 GN=ST14 PE=1 SV=2" "0.003" "False" "3.226" "1" "1" "1" "1" "855" "94.7" "6.55" "3.32" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00057, Pf00089, Pf00431, Pf01390" "6768" "ENSG00000149418" "ST14" "hsa:6768; Q9BS01; Q9H3S0; Q9HB36; Q9HCA3; Q9Y5Y6" "Formation of the cornified envelope" "" "1" "0" "0.975" "1.004" "1.053" "0.984" "1.010" "1.010" "0.948" "0.908" "0.655" "127.7" "124.5" "128.2" "134.5" "125.7" "129.1" "129.1" "121.0" "115.9" "83.6" "" "" "" "" "" "" "" "" "" "" "113.3" "103.1" "111.9" "100.6" "104.8" "118.6" "109.1" "100.0" "106.3" "83.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9103143806185528671" "False" "High" "IsMasterProtein" "Q86UA1" "Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3" "0.003" "False" "3.212" "1" "1" "2" "1" "669" "78.4" "5.40" "4.24" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "" "55015" "ENSG00000185246" "PRPF39" "hsa:55015; Q08AL1; Q08AL2; Q86UA1; Q9NUU5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3163667791895929702" "False" "High" "IsMasterProtein" "Q63ZY3" "KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KANK2 PE=1 SV=1" "0.003" "False" "3.210" "1" "1" "1" "1" "851" "91.1" "5.63" "2.85" "1" "cell organization and biogenesis;developmental processes;other biological processes" "mitochondrion;other cell component" "" "Pf12075, Pf12796" "25959" "ENSG00000197256" "KANK2" "B0I1P4; hsa:25959; Q3KQZ3; Q63ZY3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8162637103249760299" "False" "High" "IsMasterProtein" "Q14CB8" "Rho GTPase-activating protein 19 OS=Homo sapiens OX=9606 GN=ARHGAP19 PE=1 SV=1" "0.003" "False" "3.203" "4" "1" "1" "1" "494" "55.7" "9.36" "4.28" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "84986" "ENSG00000213390" "ARHGAP19" "A1XCP1; B4DZR1; hsa:84986; Q14CB8; Q14CF2; Q5J8M2; Q5T460; Q5T462; Q68DG6; Q8N9X1; Q8NF34; Q8TEK1" "RHOA GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245532746290238029" "False" "High" "IsMasterProtein" "P61353" "Large ribosomal subunit protein eL27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "0.003" "False" "3.200" "7" "1" "1" "1" "136" "15.8" "10.56" "3.52" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8539221583394441317" "False" "High" "IsMasterProtein" "O95251" "Histone acetyltransferase KAT7 OS=Homo sapiens OX=9606 GN=KAT7 PE=1 SV=1" "0.003" "False" "3.200" "2" "1" "1" "1" "611" "70.6" "8.85" "3.00" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01530, Pf01853, Pf17772" "11143" "ENSG00000136504" "KAT7" "B3KN74; B4DF85; B4DFB4; B4DFE0; B4DGY4; E7ER15; G5E9K7; hsa:11143; O95251" "HATs acetylate histones" "Androgen receptor signaling pathway" "2" "0" "0.827" "0.916" "0.944" "0.849" "0.865" "0.906" "0.768" "1.031" "0.781" "61.5" "50.9" "56.4" "58.1" "52.2" "53.2" "55.8" "47.3" "63.4" "48.0" "" "" "" "" "" "" "" "" "" "" "54.6" "42.1" "49.2" "43.5" "43.6" "48.9" "47.1" "39.1" "58.2" "48.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1029987387638648321" "False" "High" "IsMasterProtein" "Q9BWW7" "Transcriptional repressor scratch 1 OS=Homo sapiens OX=9606 GN=SCRT1 PE=1 SV=2" "0.003" "False" "3.198" "5" "1" "1" "1" "348" "35.5" "9.47" "2.74" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "83482" "ENSG00000261678; ENSG00000284923" "SCRT1" "A8MX66; hsa:83482; Q96C52; Q9BWW7" "" "" "0" "0" "0.980" "0.839" "1.160" "0.968" "1.286" "1.110" "1.218" "0.932" "0.968" "51.3" "50.2" "43.0" "59.5" "49.6" "66.0" "56.9" "62.4" "47.8" "49.6" "" "" "" "" "" "" "" "" "" "" "45.5" "41.6" "37.5" "44.5" "41.4" "60.6" "48.1" "51.6" "43.8" "49.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3258853358595528558" "False" "High" "IsMasterProtein" "Q9H8T0" "AKT-interacting protein OS=Homo sapiens OX=9606 GN=AKTIP PE=1 SV=1" "0.003" "False" "3.194" "6" "1" "1" "1" "292" "33.1" "9.31" "2.59" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "64400" "ENSG00000166971" "AKTIP" "hsa:64400; Q503B1; Q53H38; Q9H8T0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "High" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.003" "False" "3.189" "1" "1" "1" "1" "2005" "226.2" "7.30" "2.22" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7587764609471779486" "False" "High" "IsMasterProtein" "Q9P1V8" "Sterile alpha motif domain-containing protein 15 OS=Homo sapiens OX=9606 GN=SAMD15 PE=1 SV=1" "0.003" "False" "3.187" "1" "1" "1" "1" "674" "77.1" "4.45" "3.21" "1" "" "" "" "Pf07647" "161394" "ENSG00000100583" "SAMD15" "hsa:161394; Q2M3P3; Q9P1V8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8342734995322822174" "False" "High" "IsMasterProtein" "Q9UHQ4" "B-cell receptor-associated protein 29 OS=Homo sapiens OX=9606 GN=BCAP29 PE=1 SV=2" "0.003" "False" "3.186" "3" "1" "1" "1" "241" "28.3" "9.54" "2.90" "1" "transport;other biological processes" "other membranes;ER/Golgi" "" "Pf05529, Pf18035" "55973" "ENSG00000075790; ENSG00000283852" "BCAP29" "G5E9L4; hsa:55973; O95003; Q9UHQ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7160695848866474340" "False" "High" "IsMasterProtein" "Q96JG6" "Syndetin OS=Homo sapiens OX=9606 GN=VPS50 PE=1 SV=3" "0.003" "False" "3.177" "1" "1" "2" "1" "964" "111.1" "6.20" "5.74" "1" "transport" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf10474, Pf10475" "55610" "ENSG00000004766" "VPS50" "B3KX22; D1MQ00; F5H5U7; hsa:55610; Q75N07; Q8WVK3; Q96JG6; Q9H5C6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2912767912009988876" "False" "High" "IsMasterProtein" "Q8TCE6" "DENN domain-containing protein 10 OS=Homo sapiens OX=9606 GN=DENND10 PE=1 SV=1" "0.003" "False" "3.173" "2" "1" "1" "1" "357" "40.5" "6.61" "2.81" "1" "transport;other biological processes" "other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf08616" "404636" "ENSG00000119979" "DENND10" "B1AMV6; B4DDC3; D3DRC8; hsa:404636; Q8TCE6; Q9NXW4" "" "" "0" "0" "0.842" "0.950" "0.797" "0.852" "0.905" "1.055" "0.904" "0.953" "2.663" "171.5" "144.3" "162.8" "136.6" "146.1" "155.1" "180.9" "154.9" "163.4" "456.6" "" "" "" "" "" "" "" "" "" "" "152.0" "119.5" "142.1" "102.2" "121.8" "142.5" "152.9" "128.1" "149.8" "456.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579603406694116788" "False" "High" "IsMasterProtein" "Q9H0C5" "BTB/POZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BTBD1 PE=1 SV=1" "0.003" "False" "3.162" "2" "1" "1" "1" "482" "52.7" "6.10" "2.76" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf07707, Pf08005" "53339" "ENSG00000064726" "BTBD1" "A6NMI8; hsa:53339; Q9BX71; Q9H0C5; Q9NWN4" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "15q25 copy number variation" "3" "0" "0.973" "0.778" "0.694" "0.815" "0.952" "0.910" "0.578" "0.701" "4.166" "34.5" "33.6" "26.9" "24.0" "28.2" "32.9" "31.4" "20.0" "24.2" "143.9" "" "" "" "" "" "" "" "" "" "" "30.6" "27.8" "23.4" "17.9" "23.5" "30.2" "26.6" "16.5" "22.2" "143.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5292178720609404720" "False" "High" "IsMasterProtein" "Q16667" "Cyclin-dependent kinase inhibitor 3 OS=Homo sapiens OX=9606 GN=CDKN3 PE=1 SV=1" "0.003" "False" "3.161" "4" "1" "1" "1" "212" "23.8" "6.40" "2.58" "1" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05706" "1033" "ENSG00000100526" "CDKN3" "hsa:1033; Q16667; Q53ZU6; Q5U0M4; Q6P1N8; Q99585; Q9BPW7; Q9BY36; Q9C042; Q9C046; Q9C047; Q9C049; Q9C051; Q9C053" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4328558024401800768" "False" "High" "IsMasterProtein" "Q12913" "Receptor-type tyrosine-protein phosphatase eta OS=Homo sapiens OX=9606 GN=PTPRJ PE=1 SV=3" "0.003" "False" "3.148" "1" "2" "2" "2" "1337" "145.9" "5.58" "5.31" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf00102, Pf18861" "5795" "ENSG00000149177" "PTPRJ" "hsa:5795; Q12913; Q15255; Q6P4H4; Q8NHM2; Q9UDA9" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Negative regulation of FLT3; Negative regulation of MET activity" "VEGFA-VEGFR2 signaling" "5" "0" "1.037" "1.059" "1.063" "0.953" "1.006" "1.081" "0.939" "0.946" "0.688" "115.0" "119.3" "121.8" "122.3" "109.6" "115.7" "124.3" "108.1" "108.8" "79.1" "" "" "" "" "" "" "" "" "" "" "102.0" "98.8" "106.3" "91.5" "91.4" "106.3" "105.1" "89.3" "99.8" "79.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550232429458165552" "False" "High" "IsMasterProtein" "Q9NRZ9" "Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1" "0.003" "False" "3.144" "2" "1" "1" "1" "838" "97.0" "7.93" "2.89" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "3070" "ENSG00000119969" "HELLS" "B2RB41; hsa:3070; Q3LID1; Q6I7N7; Q76H76; Q76H77; Q76H78; Q76H79; Q76H80; Q76H81; Q7Z397; Q7Z5X2; Q8N6P4; Q9H4P5; Q9NRZ9" "" "Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer" "2" "0" "0.886" "0.884" "1.319" "0.751" "0.807" "0.893" "0.753" "0.780" "2.256" "22.0" "19.5" "19.5" "29.0" "16.5" "17.8" "19.7" "16.6" "17.2" "49.7" "" "" "" "" "" "" "" "" "" "" "19.5" "16.2" "17.0" "21.7" "13.8" "16.3" "16.6" "13.7" "15.8" "49.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821313339248863201" "False" "High" "IsMasterProtein" "Q8TEW0" "Partitioning defective 3 homolog OS=Homo sapiens OX=9606 GN=PARD3 PE=1 SV=2" "0.003" "False" "3.143" "1" "1" "1" "1" "1356" "151.3" "7.68" "2.36" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00595, Pf12053" "56288" "ENSG00000148498" "PARD3" "F5H5T0; hsa:56288; Q5T2U1; Q5VUA2; Q5VUA3; Q5VWV0; Q5VWV1; Q5VWV3; Q5VWV4; Q5VWV5; Q6IQ47; Q8TCZ9; Q8TEW0; Q8TEW1; Q8TEW2; Q8TEW3; Q96K28; Q96RM6; Q96RM7; Q9BY57; Q9BY58; Q9HC48; Q9NWL4; Q9NYE6" "Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "Chemokine signaling pathway; Complement system in neuronal development and plasticity" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741910088829308609" "False" "High" "IsMasterProtein" "Q9NP66" "High mobility group protein 20A OS=Homo sapiens OX=9606 GN=HMG20A PE=1 SV=1" "0.003" "False" "3.135" "4" "2" "2" "2" "347" "40.1" "6.49" "3.38" "2" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505" "10363" "ENSG00000140382" "HMG20A" "A6NHY3; D3DW78; hsa:10363; Q53G31; Q9NP66; Q9NSF6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6115091388662522029" "False" "High" "IsMasterProtein" "P55211" "Caspase-9 OS=Homo sapiens OX=9606 GN=CASP9 PE=1 SV=3" "0.003" "False" "3.133" "2" "1" "1" "1" "416" "46.3" "6.05" "3.38" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00656" "842" "ENSG00000132906" "CASP9" "B4E1A3; hsa:842; O95348; P55211; Q53Y70; Q5JRU9; Q5UGI1; Q92852; Q9BQ62; Q9UEQ3; Q9UIJ8" "Caspase activation via Dependence Receptors in the absence of ligand; Constitutive Signaling by AKT1 E17K in Cancer; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; NOD1/2 Signaling Pathway; AKT phosphorylates targets in the cytosol" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Hepatitis C and hepatocellular carcinoma; Apoptosis modulation by HSP70; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; miRNA regulation of p53 pathway in prostate cancer; NO/cGMP/PKG mediated neuroprotection; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; MTHFR deficiency; Acute viral myocarditis; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Complement system in neuronal development and plasticity; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "47" "0" "0.975" "0.963" "1.013" "0.950" "0.843" "1.013" "0.659" "0.975" "10.088" "96.3" "93.9" "92.7" "97.5" "91.5" "81.1" "97.6" "63.5" "93.9" "971.4" "" "" "" "" "" "" "" "" "" "" "85.4" "77.8" "80.9" "73.0" "76.3" "74.5" "82.5" "52.5" "86.1" "971.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5006155018502035980" "False" "High" "IsMasterProtein" "Q8WXI2" "Connector enhancer of kinase suppressor of ras 2 OS=Homo sapiens OX=9606 GN=CNKSR2 PE=1 SV=1" "0.003" "False" "3.130" "1" "1" "3" "1" "1034" "117.5" "6.79" "4.69" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00169, Pf00536, Pf00595, Pf06663, Pf10534" "22866" "ENSG00000149970" "CNKSR2" "B4DGR4; B7ZLJ1; B9EG83; E7ESA4; hsa:22866; O94976; Q5JPK4; Q5JPN0; Q8WXI1; Q8WXI2" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "" "7" "0" "0.704" "0.897" "0.892" "0.822" "0.920" "0.892" "0.998" "0.843" "0.345" "700.7" "493.5" "628.5" "624.9" "575.7" "645.0" "624.9" "699.5" "590.7" "241.6" "" "" "" "" "" "" "" "" "" "" "621.4" "408.8" "548.4" "467.3" "480.1" "592.5" "528.1" "578.2" "541.8" "241.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8956939058796420982" "False" "High" "IsMasterProtein" "Q8NGA1" "Olfactory receptor 1M1 OS=Homo sapiens OX=9606 GN=OR1M1 PE=2 SV=1" "0.003" "False" "3.129" "2" "1" "2" "1" "313" "34.8" "8.91" "3.16" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "125963" "ENSG00000170929" "OR1M1" "B9EHA6; hsa:125963; Q6IFJ3; Q8NGA1; Q96R91" "Expression and translocation of olfactory receptors" "" "1" "0" "1.144" "1.108" "0.984" "1.072" "1.054" "1.304" "0.681" "0.796" "8.774" "44.0" "50.3" "48.7" "43.3" "47.1" "46.4" "57.3" "30.0" "35.0" "385.8" "" "" "" "" "" "" "" "" "" "" "39.0" "41.7" "42.5" "32.4" "39.3" "42.6" "48.5" "24.8" "32.1" "385.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "258971474423548673" "False" "High" "IsMasterProtein" "Q14746" "Conserved oligomeric Golgi complex subunit 2 OS=Homo sapiens OX=9606 GN=COG2 PE=1 SV=1" "0.003" "False" "3.126" "1" "1" "1" "1" "738" "83.2" "6.62" "3.07" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "other molecular function" "Pf06148, Pf12022" "22796" "ENSG00000135775" "COG2" "hsa:22796; Q14746; Q86U99" "Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport; Intra-Golgi traffic" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2330995334301047008" "False" "High" "IsMasterProtein" "Q9P2X0" "Dolichol-phosphate mannosyltransferase subunit 3 OS=Homo sapiens OX=9606 GN=DPM3 PE=1 SV=2" "0.003" "False" "3.123" "11" "1" "1" "1" "92" "10.1" "5.94" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf08285" "54344" "ENSG00000179085" "DPM3" "hsa:54344; Q5SR62; Q5SR63; Q9BXN4; Q9BXN5; Q9P2X0" "Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG; Defective DPM3 causes DPM3-CDG; Defective DPM2 causes DPM2-CDG" "N-glycan biosynthesis" "5" "0" "0.931" "0.730" "0.940" "0.937" "0.846" "0.987" "0.940" "0.932" "0.683" "82.7" "77.0" "60.3" "77.7" "77.5" "70.0" "81.6" "77.8" "77.1" "56.5" "" "" "" "" "" "" "" "" "" "" "73.3" "63.8" "52.6" "58.1" "64.6" "64.3" "69.0" "64.3" "70.7" "56.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2414902147837832753" "False" "High" "IsMasterProtein" "Q969R5" "Lethal(3)malignant brain tumor-like protein 2 OS=Homo sapiens OX=9606 GN=L3MBTL2 PE=1 SV=1" "0.003" "False" "3.123" "1" "1" "1" "1" "705" "79.1" "6.84" "2.07" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf02820, Pf21319" "83746" "ENSG00000100395" "L3MBTL2" "hsa:83746; Q8TEN1; Q969R5; Q96SC4; Q9BQI2; Q9UGS4" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6" "" "2" "0" "1.911" "1.108" "1.110" "1.295" "1.156" "0.992" "0.861" "1.058" "1.946" "162.6" "310.8" "180.2" "180.4" "210.6" "187.9" "161.3" "140.0" "172.1" "316.4" "" "" "" "" "" "" "" "" "" "" "144.2" "257.4" "157.2" "134.9" "175.6" "172.6" "136.3" "115.7" "157.8" "316.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-948672987785726372" "False" "High" "IsMasterProtein" "Q9BT25" "HAUS augmin-like complex subunit 8 OS=Homo sapiens OX=9606 GN=HAUS8 PE=1 SV=3" "0.003" "False" "3.121" "2" "1" "1" "1" "410" "44.8" "7.06" "3.24" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "93323" "ENSG00000131351" "HAUS8" "B4DJA7; C9JBZ4; hsa:93323; Q49AC4; Q86WF0; Q96FX3; Q9BT25" "Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "0.896" "0.695" "0.638" "0.693" "0.537" "0.398" "0.510" "0.615" "1.990" "57.7" "51.8" "40.1" "36.8" "40.0" "31.0" "23.0" "29.5" "35.5" "114.9" "" "" "" "" "" "" "" "" "" "" "51.2" "42.9" "35.0" "27.6" "33.4" "28.5" "19.4" "24.4" "32.6" "114.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6643122719444543200" "False" "High" "IsMasterProtein" "Q96CB8" "Integrator complex subunit 12 OS=Homo sapiens OX=9606 GN=INTS12 PE=1 SV=1" "0.003" "False" "3.114" "3" "1" "1" "1" "462" "48.8" "9.69" "3.49" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628" "57117" "ENSG00000138785" "INTS12" "B2RC48; hsa:57117; Q3B6Z3; Q96CB8; Q9HD71" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "5056631154823244000" "False" "High" "IsMasterProtein" "Cont_Q3SY84" "Keratin, type II cytoskeletal 71 OS=Homo sapiens OX=9606 GN=KRT71 PE=1 SV=3" "0.003" "True" "3.111" "3" "2" "2" "1" "523" "57.3" "6.61" "6.34" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "112802" "ENSG00000139648" "KRT71" "B3KVC1; hsa:112802; Q3SY84; Q3SY85; Q96DU2" "Formation of the cornified envelope" "Vitamin D receptor pathway" "3" "0" "0.863" "0.906" "0.831" "0.649" "0.979" "0.862" "0.937" "1.016" "0.593" "599.3" "516.9" "543.1" "498.0" "388.8" "586.5" "516.8" "561.5" "608.8" "355.4" "" "" "" "" "" "" "" "" "" "" "531.5" "428.2" "473.9" "372.5" "324.2" "538.8" "436.7" "464.1" "558.3" "355.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7075560619718857491" "False" "High" "IsMasterProtein" "Q9H8G1" "Zinc finger protein 430 OS=Homo sapiens OX=9606 GN=ZNF430 PE=1 SV=3" "0.003" "False" "3.095" "7" "2" "2" "2" "570" "66.3" "8.65" "5.36" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "80264" "ENSG00000118620" "ZNF430" "hsa:80264; Q86V70; Q9H8G1" "Generic Transcription Pathway" "" "1" "0" "0.907" "0.765" "0.628" "0.806" "0.728" "0.652" "0.502" "0.846" "5.389" "110.9" "100.6" "84.8" "69.7" "89.3" "80.8" "72.3" "55.7" "93.8" "597.4" "" "" "" "" "" "" "" "" "" "" "98.3" "83.3" "74.0" "52.1" "74.5" "74.2" "61.1" "46.0" "86.0" "597.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4551451552914640426" "False" "High" "IsMasterProtein" "Q96B49" "Mitochondrial import receptor subunit TOM6 homolog OS=Homo sapiens OX=9606 GN=TOMM6 PE=1 SV=1" "0.004" "False" "3.081" "19" "1" "1" "1" "74" "8.0" "4.89" "1.66" "1" "cell organization and biogenesis;transport" "other membranes;mitochondrion" "" "Pf15184" "100188893" "ENSG00000214736" "TOMM6" "B2DG15; hsa:100188893; Q96B49; Q9UH52" "PINK1-PRKN Mediated Mitophagy; Mitochondrial protein import" "" "2" "0" "1.194" "1.155" "1.808" "1.031" "0.932" "1.127" "0.882" "1.008" "0.752" "25.4" "30.3" "29.3" "45.9" "26.2" "23.7" "28.6" "22.4" "25.6" "19.1" "" "" "" "" "" "" "" "" "" "" "22.5" "25.1" "25.6" "34.4" "21.8" "21.7" "24.2" "18.5" "23.5" "19.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1413816697731650822" "False" "High" "IsMasterProtein" "Q9BU64" "Centromere protein O OS=Homo sapiens OX=9606 GN=CENPO PE=1 SV=1" "0.004" "False" "3.081" "3" "1" "1" "1" "300" "33.8" "7.71" "2.60" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf09496" "79172" "ENSG00000138092" "CENPO" "B2RDC0; D6W536; hsa:79172; Q53T55; Q96JV3; Q9BU64" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "713100355738171482" "False" "High" "IsMasterProtein" "Q8N302" "Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens OX=9606 GN=AGGF1 PE=1 SV=2" "0.004" "False" "3.081" "1" "1" "1" "1" "714" "80.9" "5.44" "3.22" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity" "Pf00498, Pf01585, Pf17780" "55109" "ENSG00000164252" "AGGF1" "hsa:55109; O00581; Q53YS3; Q8N302; Q9BU84; Q9NW66" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "0.985" "0.821" "0.830" "0.750" "0.897" "0.791" "0.621" "0.805" "2.356" "258.5" "254.6" "212.2" "214.4" "194.0" "231.9" "204.4" "160.5" "208.1" "608.9" "" "" "" "" "" "" "" "" "" "" "229.2" "210.9" "185.2" "160.3" "161.7" "213.1" "172.7" "132.6" "190.9" "608.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5978102986579792947" "False" "High" "IsMasterProtein" "Q69YL0" "Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1" "0.004" "False" "3.081" "8" "1" "1" "1" "99" "10.9" "12.00" "2.67" "1" "" "" "" "" "" "ENSG00000270170" "NCBP2AS2" "Q69YL0" "" "3q29 copy number variation syndrome" "1" "0" "1.181" "1.105" "1.173" "1.217" "1.158" "1.168" "1.241" "1.049" "0.686" "130.6" "154.2" "144.3" "153.2" "158.9" "151.3" "152.5" "162.1" "137.0" "89.6" "" "" "" "" "" "" "" "" "" "" "115.8" "127.7" "125.9" "114.6" "132.5" "139.0" "128.9" "134.0" "125.6" "89.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6931862210339099933" "False" "High" "IsMasterProtein" "Q9H1B7" "Probable E3 ubiquitin-protein ligase IRF2BPL OS=Homo sapiens OX=9606 GN=IRF2BPL PE=1 SV=1" "0.004" "False" "3.080" "2" "1" "1" "1" "796" "82.6" "8.24" "2.26" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "64207" "ENSG00000119669" "IRF2BPL" "hsa:64207; Q8NDQ2; Q96JG2; Q9H1B7; Q9H3I7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2215582295517957266" "False" "High" "IsMasterProtein" "O15155" "BET1 homolog OS=Homo sapiens OX=9606 GN=BET1 PE=1 SV=1" "0.004" "False" "3.077" "9" "1" "1" "1" "118" "13.3" "9.06" "2.38" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi" "other molecular function" "" "10282" "ENSG00000105829" "BET1" "hsa:10282; O15155; Q96EA0" "COPI-mediated anterograde transport; COPII-mediated vesicle transport" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3888271252204207662" "False" "High" "IsMasterProtein" "Q9UM73" "ALK tyrosine kinase receptor OS=Homo sapiens OX=9606 GN=ALK PE=1 SV=3" "0.004" "False" "3.075" "1" "1" "1" "1" "1620" "176.3" "7.08" "3.33" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00629, Pf07714, Pf12810" "238" "ENSG00000171094" "ALK" "A6P4T4; A6P4V4; hsa:238; Q4ZFX9; Q53QQ6; Q53RZ4; Q59FI3; Q9UM73; Q9Y4K6" "Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; Signaling by ALK; MDK and PTN in ALK signaling; ASP-3026-resistant ALK mutants; NVP-TAE684-resistant ALK mutants; alectinib-resistant ALK mutants; brigatinib-resistant ALK mutants; ceritinib-resistant ALK mutants; crizotinib-resistant ALK mutants; lorlatinib-resistant ALK mutants" "Pluripotent stem cell differentiation pathway; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer" "14" "0" "0.830" "0.761" "0.819" "0.576" "0.961" "0.786" "0.840" "0.902" "0.453" "418.2" "347.1" "318.2" "342.7" "240.9" "402.1" "328.5" "351.5" "377.3" "189.6" "" "" "" "" "" "" "" "" "" "" "370.9" "287.5" "277.7" "256.3" "200.9" "369.3" "277.7" "290.5" "346.1" "189.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-829436805144986471" "False" "High" "IsMasterProtein" "P61927" "Large ribosomal subunit protein eL37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2" "0.004" "False" "3.070" "7" "1" "3" "1" "97" "11.1" "11.74" "8.30" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01907" "6167" "ENSG00000145592" "RPL37" "B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "0.931" "0.931" "0.817" "0.846" "0.992" "0.922" "0.866" "0.936" "0.541" "1061.6" "987.9" "988.5" "867.3" "898.1" "1052.8" "978.9" "919.7" "993.8" "574.8" "" "" "" "" "" "" "" "" "" "" "941.4" "818.4" "862.5" "648.6" "748.9" "967.1" "827.3" "760.2" "911.4" "574.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627710569246967084" "False" "High" "IsMasterProtein" "P11831" "Serum response factor OS=Homo sapiens OX=9606 GN=SRF PE=1 SV=1" "0.004" "False" "3.070" "4" "2" "2" "2" "508" "51.6" "8.10" "2.69" "2" "cell adhesion;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319" "6722" "ENSG00000112658" "SRF" "hsa:6722; P11831; Q5T648" "RHO GTPases Activate Formins; NGF-stimulated transcription; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Cardiogenesis; Regulation of NPAS4 gene transcription" "Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Genes targeted by miRNAs in adipocytes; Cell differentiation - expanded index; Cell differentiation - index; Mesodermal commitment pathway; Mesodermal commitment pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; PDGFR-beta pathway; Envelope proteins and their potential roles in EDMD physiopathology; 22q11.2 copy number variation syndrome; Insulin signaling; Orexin receptor pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7192865757646021535" "False" "High" "IsMasterProtein" "Q7Z7G8" "Intermembrane lipid transfer protein VPS13B OS=Homo sapiens OX=9606 GN=VPS13B PE=1 SV=2" "0.004" "False" "3.068" "0" "1" "1" "1" "4022" "448.4" "6.46" "3.15" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf06650, Pf12624, Pf16909" "157680" "ENSG00000132549" "VPS13B" "C9JD30; hsa:157680; Q709C6; Q709C7; Q7Z7G4; Q7Z7G5; Q7Z7G6; Q7Z7G7; Q7Z7G8; Q8NB77; Q9NWV1; Q9Y4E7" "" "" "0" "0" "0.975" "0.907" "1.081" "0.923" "0.829" "0.832" "0.826" "0.860" "0.700" "145.9" "142.3" "132.3" "157.8" "134.6" "120.9" "121.4" "120.5" "125.4" "102.1" "" "" "" "" "" "" "" "" "" "" "129.4" "117.8" "115.4" "118.0" "112.3" "111.1" "102.6" "99.6" "115.0" "102.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5265324397927722466" "False" "High" "IsMasterProtein" "Q6PIW4" "Fidgetin-like protein 1 OS=Homo sapiens OX=9606 GN=FIGNL1 PE=1 SV=2" "0.004" "False" "3.063" "3" "1" "1" "1" "674" "74.0" "7.85" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004, Pf09336, Pf17862" "63979" "ENSG00000132436" "FIGNL1" "D3DVM6; hsa:63979; Q6PIW4; Q86V18; Q8ND59; Q9H8P1; Q9H917" "" "" "0" "0" "0.949" "0.956" "1.229" "1.234" "1.035" "1.138" "1.177" "1.003" "1.677" "43.7" "41.4" "41.7" "53.6" "53.9" "45.2" "49.7" "51.4" "43.8" "73.2" "" "" "" "" "" "" "" "" "" "" "38.7" "34.3" "36.4" "40.1" "44.9" "41.5" "42.0" "42.5" "40.1" "73.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8810414112164205375" "False" "High" "IsMasterProtein" "Q8WTW4" "GATOR1 complex protein NPRL2 OS=Homo sapiens OX=9606 GN=NPRL2 PE=1 SV=2" "0.004" "False" "3.063" "2" "1" "1" "1" "380" "43.6" "6.52" "3.23" "1" "stress response;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf06218" "10641" "ENSG00000114388" "NPRL2" "A8K831; hsa:10641; Q6FGS2; Q8WTW4; Q9Y249; Q9Y497" "Amino acids regulate mTORC1" "22q11.2 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779285951144314922" "False" "High" "IsMasterProtein" "Q8IUH3" "RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1" "0.004" "False" "3.059" "2" "1" "1" "1" "476" "53.5" "7.17" "3.07" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "129831" "ENSG00000155636" "RBM45" "hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8281195296370466031" "False" "High" "IsMasterProtein" "P0CG13" "Chromosome transmission fidelity protein 8 homolog OS=Homo sapiens OX=9606 GN=CHTF8 PE=1 SV=1" "0.004" "False" "3.042" "11" "1" "1" "1" "121" "13.3" "8.18" "3.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf09696" "54921" "ENSG00000168802" "CHTF8" "A8MYX8; hsa:54921; P0CG13; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "Polymerase switching on the C-strand of the telomere" "Gastric cancer network 2" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.004" "False" "3.040" "4" "2" "2" "1" "395" "43.9" "5.99" "5.23" "2" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417113921000243817" "False" "High" "IsMasterProtein" "Q5JPI3" "Uncharacterized protein C3orf38 OS=Homo sapiens OX=9606 GN=C3orf38 PE=1 SV=1" "0.004" "False" "3.037" "2" "1" "1" "1" "329" "37.5" "6.47" "3.93" "1" "other biological processes" "nucleus" "" "Pf15008" "285237" "ENSG00000179021" "C3orf38" "B2R8X6; hsa:285237; Q5JPI3; Q8TC85" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3551068469878704149" "False" "High" "IsMasterProtein" "Q9H0U6" "Large ribosomal subunit protein uL18m OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" "0.004" "False" "3.036" "4" "1" "2" "1" "180" "20.6" "9.54" "5.09" "1" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00861" "29074" "ENSG00000112110" "MRPL18" "hsa:29074; Q5TAP9; Q9H0U6; Q9NZW8" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833474538863443704" "False" "High" "IsMasterProtein" "Q9NXZ2" "Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens OX=9606 GN=DDX43 PE=1 SV=2" "0.004" "False" "3.026" "3" "2" "3" "2" "648" "72.8" "8.75" "4.74" "2" "" "" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00270, Pf00271" "55510" "ENSG00000080007" "DDX43" "B4E0C8; hsa:55510; Q6NXR1; Q9NXZ2" "" "" "0" "0" "0.875" "1.082" "0.935" "0.987" "0.579" "1.013" "0.991" "0.748" "0.396" "320.9" "280.9" "347.1" "299.9" "316.8" "185.8" "325.2" "317.9" "240.0" "127.2" "" "" "" "" "" "" "" "" "" "" "284.6" "232.7" "302.9" "224.3" "264.2" "170.7" "274.8" "262.8" "220.1" "127.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7327599600572382898" "False" "High" "IsMasterProtein" "P08473" "Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2" "0.004" "False" "3.019" "2" "2" "2" "2" "750" "85.5" "5.73" "5.11" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01431, Pf05649" "4311" "ENSG00000196549" "MME" "A8K6U6; D3DNJ9; hsa:4311; P08473; Q3MIX4" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Physiological factors" "Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease" "6" "0" "0.971" "0.936" "0.925" "0.941" "1.035" "0.960" "0.900" "1.162" "0.788" "572.2" "555.5" "535.7" "529.6" "538.7" "592.4" "549.5" "515.0" "665.0" "451.0" "" "" "" "" "" "" "" "" "" "" "507.4" "460.2" "467.4" "396.0" "449.2" "544.2" "464.4" "425.6" "609.9" "451.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6335847497915133656" "False" "High" "IsMasterProtein" "Q9BTY7" "Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1" "0.004" "False" "3.017" "2" "1" "1" "1" "390" "42.1" "4.81" "3.31" "1" "" "" "" "Pf04063, Pf04064" "51236" "ENSG00000235173" "HGH1" "hsa:51236; P0CB43; Q9BTY7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079825360121275387" "False" "High" "IsMasterProtein" "Q5SNV9" "Uncharacterized protein C1orf167 OS=Homo sapiens OX=9606 GN=C1orf167 PE=2 SV=3" "0.004" "False" "3.016" "1" "1" "1" "1" "1449" "160.4" "10.89" "2.72" "1" "" "" "" "Pf15736" "" "" "C1orf167" "A0A8I5KXP5; hsa:284498" "" "" "0" "0" "0.992" "0.928" "0.985" "0.985" "1.068" "1.121" "0.918" "0.875" "8.313" "77.3" "76.6" "71.8" "76.1" "76.1" "82.5" "86.6" "71.0" "67.6" "642.5" "" "" "" "" "" "" "" "" "" "" "68.5" "63.5" "62.6" "56.9" "63.5" "75.8" "73.2" "58.7" "62.0" "642.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8504689738561094897" "False" "High" "IsMasterProtein" "O43303" "Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens OX=9606 GN=CCP110 PE=1 SV=3" "0.004" "False" "3.011" "1" "1" "1" "1" "1012" "113.4" "8.65" "2.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf16025" "9738" "ENSG00000103540" "CCP110" "B7WP23; hsa:9738; O43303; O43335; Q68DV9; Q8NE13" "Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle" "Joubert syndrome" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "High" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.005" "False" "3.005" "10" "1" "1" "1" "110" "11.3" "6.54" "2.85" "1" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "Antimicrobial peptides" "" "1" "0" "0.540" "0.517" "0.722" "0.711" "0.767" "0.435" "0.404" "0.889" "0.672" "140.6" "76.0" "72.8" "101.5" "100.0" "107.8" "61.2" "56.8" "125.0" "94.5" "" "" "" "" "" "" "" "" "" "" "124.7" "62.9" "63.5" "75.9" "83.4" "99.0" "51.7" "47.0" "114.6" "94.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1273704181858751884" "False" "High" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "0.005" "False" "3.004" "2" "1" "1" "1" "340" "37.3" "8.73" "3.41" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "1.064" "1.035" "1.205" "1.052" "1.098" "1.038" "1.075" "1.002" "0.565" "224.7" "239.1" "232.6" "270.6" "236.5" "246.8" "233.3" "241.6" "225.1" "126.9" "" "" "" "" "" "" "" "" "" "" "199.2" "198.0" "203.0" "202.4" "197.2" "226.7" "197.2" "199.7" "206.4" "126.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8289862670679680301" "False" "High" "IsMasterProtein" "Q96EK7" "Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Homo sapiens OX=9606 GN=FAM120B PE=1 SV=1" "0.005" "False" "2.993" "3" "1" "1" "1" "910" "103.7" "5.69" "3.61" "1" "signal transduction;other biological processes" "nucleus" "" "" "84498" "ENSG00000112584; ENSG00000275333" "FAM120B" "B4DL34; hsa:84498; Q86V68; Q96EK7; Q96JI9" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "" "2" "0" "1.067" "1.060" "1.256" "0.997" "0.945" "1.064" "0.695" "0.926" "5.696" "74.4" "79.4" "78.9" "93.5" "74.2" "70.3" "79.2" "51.7" "68.9" "423.9" "" "" "" "" "" "" "" "" "" "" "66.0" "65.8" "68.9" "69.9" "61.8" "64.6" "66.9" "42.8" "63.2" "423.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7492712467309811415" "False" "High" "IsMasterProtein" "Q8WU58" "Protein FAM222B OS=Homo sapiens OX=9606 GN=FAM222B PE=1 SV=1" "0.005" "False" "2.990" "1" "1" "1" "1" "562" "59.6" "9.23" "2.87" "1" "" "nucleus" "" "Pf15258" "55731" "ENSG00000173065" "FAM222B" "hsa:55731; Q8WU58; Q9H6F3; Q9NVJ4; Q9NXN6" "" "" "0" "0" "0.946" "0.801" "0.963" "0.832" "0.800" "0.832" "0.745" "0.868" "1.013" "174.7" "165.2" "139.9" "168.2" "145.4" "139.7" "145.4" "130.2" "151.7" "177.0" "" "" "" "" "" "" "" "" "" "" "154.9" "136.8" "122.1" "125.8" "121.3" "128.4" "122.9" "107.6" "139.2" "177.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7114362037868025430" "False" "High" "IsMasterProtein" "Q5THK1" "Protein PRR14L OS=Homo sapiens OX=9606 GN=PRR14L PE=1 SV=1" "0.005" "False" "2.982" "1" "1" "1" "1" "2151" "237.2" "6.33" "3.18" "1" "" "" "" "Pf15386" "253143" "ENSG00000183530" "PRR14L" "hsa:253143; Q5THK1; Q5THK4; Q6ZNN1; Q6ZWH0; Q8IW74; Q9H5T4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5012113633319324654" "False" "High" "IsMasterProtein" "Q9BRR8" "G patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GPATCH1 PE=1 SV=1" "0.005" "False" "2.982" "2" "1" "1" "1" "931" "103.3" "7.05" "1.95" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf07713" "55094" "ENSG00000076650" "GPATCH1" "hsa:55094; Q8IZV6; Q8N3B7; Q9BRR8; Q9NW94" "mRNA Splicing - Major Pathway" "" "1" "0" "4.941" "0.831" "3.194" "2.326" "3.024" "2.374" "0.772" "1.849" "1.236" "87.0" "429.8" "72.3" "277.9" "202.3" "263.1" "206.5" "67.2" "160.9" "107.6" "" "" "" "" "" "" "" "" "" "" "77.1" "356.1" "63.1" "207.8" "168.7" "241.6" "174.5" "55.5" "147.5" "107.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2298724030714644089" "False" "High" "IsMasterProtein" "O43674" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB5 PE=1 SV=1" "0.005" "False" "2.980" "10" "2" "2" "2" "189" "21.7" "9.63" "4.07" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "transporter activity" "Pf09781" "4711" "ENSG00000136521" "NDUFB5" "hsa:4711; O43674; Q561V6" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.883" "0.885" "1.143" "1.006" "1.064" "0.987" "1.139" "1.108" "0.697" "111.7" "98.7" "98.9" "127.7" "112.4" "118.9" "110.3" "127.3" "123.8" "77.9" "" "" "" "" "" "" "" "" "" "" "99.1" "81.7" "86.3" "95.5" "93.8" "109.2" "93.2" "105.2" "113.6" "77.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5797978110445315662" "False" "High" "IsMasterProtein" "Q9BZG1" "Ras-related protein Rab-34 OS=Homo sapiens OX=9606 GN=RAB34 PE=1 SV=1" "0.005" "False" "2.980" "3" "1" "1" "1" "259" "29.0" "7.88" "3.30" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "83871" "ENSG00000109113" "RAB34" "B4E3A0; E9PEJ9; hsa:83871; Q5BJE6; Q8NCJ8; Q96AR4; Q9BZG1" "RAB geranylgeranylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3754812835242028685" "False" "High" "IsMasterProtein" "Q6ZSR9" "Uncharacterized protein FLJ45252 OS=Homo sapiens OX=9606 PE=1 SV=2" "0.005" "False" "2.979" "4" "1" "2" "1" "355" "38.0" "5.26" "2.48" "1" "" "" "" "Pf15282" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2182760318696824759" "False" "High" "IsMasterProtein" "Q8IWP9" "Coiled-coil domain-containing protein 28A OS=Homo sapiens OX=9606 GN=CCDC28A PE=1 SV=1" "0.005" "False" "2.975" "6" "1" "1" "1" "274" "30.3" "9.25" "2.60" "1" "" "" "" "Pf13270" "25901" "" "CCDC28A" "E1P591; Q32NC7; Q66K67; Q8IWP9; Q96E23; Q9Y430" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8998868825977106546" "False" "High" "IsMasterProtein" "Q9H3Z4" "DnaJ homolog subfamily C member 5 OS=Homo sapiens OX=9606 GN=DNAJC5 PE=1 SV=1" "0.005" "False" "2.971" "4" "1" "1" "1" "198" "22.1" "5.07" "3.36" "1" "cell-cell signaling;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00226" "80331" "ENSG00000101152" "DNAJC5" "A8K0M0; B3KY68; E1P5G8; hsa:80331; Q9H3Z4; Q9H3Z5; Q9H7H2" "Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation" "" "3" "0" "1.040" "0.902" "0.862" "0.841" "0.954" "0.942" "0.970" "1.063" "0.700" "404.9" "421.2" "365.2" "349.1" "340.4" "386.5" "381.6" "392.8" "430.5" "283.7" "" "" "" "" "" "" "" "" "" "" "359.1" "348.9" "318.6" "261.1" "283.9" "355.0" "322.5" "324.7" "394.8" "283.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.005" "False" "2.964" "4" "2" "2" "2" "381" "41.9" "5.66" "4.65" "2" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "Neutrophil degranulation" "" "1" "0" "1.041" "1.083" "1.244" "0.963" "0.827" "1.034" "1.281" "1.585" "6.071" "100.1" "104.2" "108.4" "124.4" "96.3" "82.7" "103.5" "128.1" "158.6" "607.5" "" "" "" "" "" "" "" "" "" "" "88.7" "86.3" "94.5" "93.1" "80.3" "76.0" "87.4" "105.9" "145.4" "607.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "High" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.005" "False" "2.953" "2" "1" "1" "1" "633" "69.5" "6.28" "3.49" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "0.999" "0.932" "0.998" "0.891" "0.867" "0.921" "0.752" "0.892" "5.257" "170.2" "170.0" "158.7" "169.9" "151.7" "147.6" "156.7" "128.1" "151.8" "895.0" "" "" "" "" "" "" "" "" "" "" "151.0" "140.8" "138.5" "127.1" "126.5" "135.6" "132.5" "105.9" "139.3" "895.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187595421119904315" "False" "High" "IsMasterProtein" "Q96K31" "Uncharacterized protein C8orf76 OS=Homo sapiens OX=9606 GN=C8orf76 PE=1 SV=1" "0.005" "False" "2.952" "2" "1" "1" "1" "380" "43.2" "5.43" "3.96" "1" "" "" "" "Pf17826" "84933" "ENSG00000189376" "C8orf76" "hsa:84933; Q53HC1; Q96K31" "" "" "0" "0" "0.967" "0.927" "0.949" "0.950" "1.109" "0.935" "0.924" "0.868" "0.769" "315.7" "305.1" "292.5" "299.7" "299.9" "350.0" "295.2" "291.8" "273.8" "242.7" "" "" "" "" "" "" "" "" "" "" "279.9" "252.8" "255.2" "224.1" "250.1" "321.5" "249.5" "241.2" "251.2" "242.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-880435081762619547" "False" "High" "IsMasterProtein" "Q09666" "Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2" "0.005" "False" "2.952" "0" "1" "2" "1" "5890" "628.7" "6.15" "4.10" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "79026" "ENSG00000124942" "AHNAK" "A1A586; hsa:79026; Q09666" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7170816328475154252" "False" "High" "IsMasterProtein" "Cont_Q2KJF1" "Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1" "0.005" "True" "2.951" "2" "1" "1" "1" "503" "53.5" "5.43" "2.64" "1" "" "non-structural extracellular;plasma membrane;other membranes" "" "Pf00047" "518955" "ENSBTAG00000009735" "A1BG" "bta:518955; Q2KJF1" "Neutrophil degranulation; Platelet degranulation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1006900541340896010" "False" "High" "IsMasterProtein" "Q2M2Z5" "Centrosomal protein kizuna OS=Homo sapiens OX=9606 GN=KIZ PE=1 SV=2" "0.005" "False" "2.946" "1" "1" "1" "1" "673" "75.1" "5.62" "2.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "" "55857" "ENSG00000088970" "KIZ" "B4DDE9; B4DK54; hsa:55857; Q2M2Z5; Q4G0M8; Q4G0S5; Q5BKY3; Q6P0M6; Q71ME0; Q9NZ35" "" "Ciliopathies" "1" "0" "0.837" "0.706" "0.841" "0.734" "0.669" "0.783" "0.946" "0.917" "0.793" "49.2" "41.2" "34.7" "41.3" "36.1" "32.9" "38.5" "46.5" "45.1" "39.0" "" "" "" "" "" "" "" "" "" "" "43.6" "34.1" "30.3" "30.9" "30.1" "30.2" "32.5" "38.4" "41.3" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4899059138870577225" "False" "High" "IsMasterProtein" "Q7Z7F7" "Large ribosomal subunit protein mL55 OS=Homo sapiens OX=9606 GN=MRPL55 PE=1 SV=1" "0.005" "False" "2.944" "6" "1" "1" "1" "128" "15.1" "11.15" "3.41" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09776" "128308" "ENSG00000162910" "MRPL55" "hsa:128308; Q5TBY3; Q5TBY6; Q6UWI8; Q7Z7F7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7190222159830229495" "False" "High" "IsMasterProtein" "Q9H0A0" "RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2" "0.005" "False" "2.940" "1" "1" "1" "1" "1025" "115.7" "8.27" "2.84" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05127, Pf08351, Pf13718, Pf13725" "55226" "ENSG00000135372" "NAT10" "B4DFD5; E7ESU4; E9PMN9; hsa:55226; Q86WK5; Q9C0F4; Q9H0A0; Q9HA61; Q9NVF2" "rRNA modification in the nucleus and cytosol" "Metapathway biotransformation Phase I and II" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3532720828751184257" "False" "High" "IsMasterProtein" "Q9UM00" "Calcium load-activated calcium channel OS=Homo sapiens OX=9606 GN=TMCO1 PE=1 SV=2" "0.005" "False" "2.939" "4" "1" "1" "1" "239" "27.1" "10.26" "2.90" "1" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi" "transporter activity;translation activity" "Pf01956" "54499" "ENSG00000143183" "TMCO1" "B2REA0; hsa:54499; J9JIE6; O75545; Q9BZS3; Q9BZU8; Q9UM00" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5113146668834443448" "False" "High" "IsMasterProtein" "Q9NRG4" "N-lysine methyltransferase SMYD2 OS=Homo sapiens OX=9606 GN=SMYD2 PE=1 SV=2" "0.005" "False" "2.931" "4" "2" "2" "2" "433" "49.7" "6.71" "4.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "56950" "ENSG00000143499" "SMYD2" "B2R9P9; hsa:56950; I6L9H7; Q4V765; Q5VSH9; Q96AI4; Q9NRG4" "PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation" "Histone modifications" "3" "0" "1.119" "0.906" "1.247" "1.002" "1.003" "1.181" "0.965" "0.857" "1.510" "265.3" "296.8" "240.3" "330.9" "265.9" "266.1" "313.3" "255.9" "227.3" "400.4" "" "" "" "" "" "" "" "" "" "" "235.2" "245.9" "209.7" "247.5" "221.7" "244.4" "264.8" "211.5" "208.5" "400.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107037615117632570" "False" "High" "IsMasterProtein" "P07992" "DNA excision repair protein ERCC-1 OS=Homo sapiens OX=9606 GN=ERCC1 PE=1 SV=1" "0.005" "False" "2.928" "4" "1" "1" "1" "297" "32.5" "6.25" "2.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00633, Pf03834" "2067" "ENSG00000012061" "ERCC1" "B2RC01; B3KRR0; hsa:2067; P07992; Q7Z7F5; Q96S40" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "9" "0" "1.110" "0.798" "0.900" "1.029" "0.921" "0.966" "0.944" "0.868" "4.143" "36.3" "40.3" "28.9" "32.7" "37.3" "33.4" "35.0" "34.2" "31.5" "150.3" "" "" "" "" "" "" "" "" "" "" "32.2" "33.4" "25.2" "24.4" "31.1" "30.7" "29.6" "28.3" "28.9" "150.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6193405881908269563" "False" "High" "IsMasterProtein" "O15156" "Zinc finger and BTB domain-containing protein 7B OS=Homo sapiens OX=9606 GN=ZBTB7B PE=1 SV=2" "0.005" "False" "2.928" "1" "1" "1" "1" "539" "58.0" "5.86" "2.76" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51043" "ENSG00000160685" "ZBTB7B" "B4E3K5; D3DV83; hsa:51043; J3KQQ3; O15156; Q68DR2; Q96EP2" "" "Ectoderm differentiation; Ectoderm differentiation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7687733002656654502" "False" "High" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "0.005" "False" "2.921" "2" "1" "1" "1" "435" "49.9" "6.27" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Insulin receptor recycling; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4245870540652335533" "False" "High" "IsMasterProtein" "Q8N8N7" "Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1" "0.005" "False" "2.919" "2" "1" "1" "1" "351" "38.5" "5.41" "3.04" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00107, Pf16884" "145482" "ENSG00000140043" "PTGR2" "hsa:145482; Q3L8A4; Q6MZH8; Q8N8N7" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984281592385059565" "False" "High" "IsMasterProtein" "Q6ZU35" "Capping protein-inhibiting regulator of actin dynamics OS=Homo sapiens OX=9606 GN=CRACD PE=1 SV=3" "0.005" "False" "2.913" "2" "2" "2" "2" "1233" "136.7" "5.60" "5.87" "2" "cell organization and biogenesis;other biological processes" "cytosol" "" "Pf15262" "57482" "ENSG00000109265" "CRACD" "hsa:57482; Q6ZU35; Q9NTE2; Q9NTP8; Q9ULK9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867666717425813757" "False" "High" "IsMasterProtein" "Q8IXM2" "Chromatin complexes subunit BAP18 OS=Homo sapiens OX=9606 GN=BAP18 PE=1 SV=1" "0.005" "False" "2.908" "6" "1" "1" "1" "172" "17.9" "7.33" "3.06" "1" "cell organization and biogenesis" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "124944" "ENSG00000258315" "BAP18" "B4DIV3; C9J4G0; E9PB29; hsa:124944; Q8IXM2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-13985934146586024" "False" "High" "IsMasterProtein" "Q9HB65" "RNA polymerase II elongation factor ELL3 OS=Homo sapiens OX=9606 GN=ELL3 PE=1 SV=2" "0.005" "False" "2.904" "4" "2" "2" "2" "397" "45.3" "6.06" "5.03" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07303, Pf10390" "80237" "ENSG00000128886" "ELL3" "B3KQ66; B3KX08; hsa:80237; Q6I9Z7; Q9H634; Q9HB65" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.948" "0.854" "0.943" "0.855" "0.850" "0.851" "0.668" "0.719" "2.356" "278.8" "264.2" "238.2" "262.9" "238.3" "237.0" "237.4" "186.1" "200.4" "656.9" "" "" "" "" "" "" "" "" "" "" "247.2" "218.9" "207.8" "196.6" "198.7" "217.7" "200.6" "153.8" "183.8" "656.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5169134958616220950" "False" "High" "IsMasterProtein" "O95848" "Uridine diphosphate glucose pyrophosphatase NUDT14 OS=Homo sapiens OX=9606 GN=NUDT14 PE=1 SV=2" "0.005" "False" "2.886" "4" "1" "2" "1" "222" "24.1" "5.05" "5.53" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "" "256281" "ENSG00000183828" "NUDT14" "hsa:256281; O95848; Q86SJ8" "Synthesis of dolichyl-phosphate-glucose" "" "1" "0" "0.963" "0.964" "0.871" "0.852" "0.878" "0.909" "0.837" "0.827" "0.466" "329.7" "317.7" "317.8" "287.3" "281.0" "289.4" "299.9" "276.0" "272.6" "153.8" "" "" "" "" "" "" "" "" "" "" "292.4" "263.1" "277.3" "214.9" "234.3" "265.9" "253.4" "228.2" "250.0" "153.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3092992993917372459" "False" "High" "IsMasterProtein" "Q9HAH7" "Probable fibrosin-1 OS=Homo sapiens OX=9606 GN=FBRS PE=1 SV=3" "0.005" "False" "2.885" "4" "1" "1" "1" "460" "48.4" "9.95" "3.93" "1" "" "" "" "Pf15336" "64319" "ENSG00000156860" "FBRS" "B4DP86; hsa:64319; Q96CI9; Q9H9X4; Q9HAH7" "" "" "0" "0" "0.875" "0.916" "1.098" "0.933" "0.942" "0.989" "1.027" "0.976" "0.629" "131.6" "115.2" "120.6" "144.6" "122.9" "124.0" "130.3" "135.3" "128.5" "82.8" "" "" "" "" "" "" "" "" "" "" "116.7" "95.5" "105.2" "108.1" "102.5" "113.9" "110.1" "111.8" "117.8" "82.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4360262701936341106" "False" "High" "IsMasterProtein" "Q96MD7" "Uncharacterized protein C9orf85 OS=Homo sapiens OX=9606 GN=C9orf85 PE=1 SV=1" "0.005" "False" "2.883" "4" "1" "1" "1" "179" "20.2" "9.42" "3.75" "1" "" "" "" "Pf10217" "138241" "ENSG00000155621" "C9orf85" "hsa:138241; Q5W0N1; Q5W0N3; Q6PJW9; Q86U95; Q96MD7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1736163179168070894" "False" "High" "IsMasterProtein" "Q9Y2V7" "Conserved oligomeric Golgi complex subunit 6 OS=Homo sapiens OX=9606 GN=COG6 PE=1 SV=2" "0.005" "False" "2.875" "1" "1" "1" "1" "657" "73.2" "5.76" "2.83" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf06419, Pf20653" "57511" "ENSG00000133103" "COG6" "hsa:57511; Q5T0U1; Q6AI19; Q86V49; Q9ULT5; Q9Y2V7" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4161818119007266512" "False" "High" "IsMasterProtein" "O43521" "Bcl-2-like protein 11 OS=Homo sapiens OX=9606 GN=BCL2L11 PE=1 SV=1" "0.005" "False" "2.867" "6" "1" "1" "1" "198" "22.2" "8.21" "3.01" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf06773, Pf08945" "10018" "ENSG00000153094" "BCL2L11" "A8K2W2; hsa:10018; O43521; O43522; Q0MSE7; Q0MSE8; Q0MSE9; Q53R28; Q6JTU6; Q6T851; Q6TE14; Q6TE15; Q6TE16; Q6V402; Q8WYL6; Q8WYL7; Q8WYL8; Q8WYL9; Q8WYM0; Q8WYM1" "NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes" "Apoptosis modulation and signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; 2q13 copy number variation syndrome; ErbB signaling pathway; DNA damage response (only ATM dependent)" "24" "0" "1.349" "1.084" "0.820" "0.969" "1.020" "1.060" "0.869" "0.986" "0.429" "35.1" "47.3" "38.0" "28.7" "34.0" "35.8" "37.2" "30.5" "34.6" "15.0" "" "" "" "" "" "" "" "" "" "" "31.1" "39.2" "33.1" "21.5" "28.3" "32.8" "31.4" "25.2" "31.7" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "201437280160465728" "False" "High" "IsMasterProtein" "Q9H9E3" "Conserved oligomeric Golgi complex subunit 4 OS=Homo sapiens OX=9606 GN=COG4 PE=1 SV=3" "0.005" "False" "2.852" "1" "1" "1" "1" "785" "89.0" "5.19" "2.50" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf08318, Pf20662, Pf20663" "25839" "ENSG00000103051" "COG4" "B4DMN8; C9JS23; hsa:25839; Q96D40; Q9BRF0; Q9BVZ2; Q9H5Y4; Q9H9E3; Q9Y3W3" "Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport; Intra-Golgi traffic" "" "3" "0" "1.162" "1.109" "1.287" "0.925" "1.014" "0.951" "0.910" "1.183" "3.682" "83.2" "96.6" "92.2" "107.0" "77.0" "84.3" "79.1" "75.7" "98.4" "306.2" "" "" "" "" "" "" "" "" "" "" "73.7" "80.0" "80.4" "80.0" "64.2" "77.4" "66.8" "62.6" "90.3" "306.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865855424515257827" "False" "High" "IsMasterProtein" "Q9H0F6" "Sharpin OS=Homo sapiens OX=9606 GN=SHARPIN PE=1 SV=1" "0.005" "False" "2.851" "2" "1" "1" "1" "387" "39.9" "5.80" "2.31" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16764" "81858" "ENSG00000179526" "SHARPIN" "A6NEG3; C0L3L2; D3DWL3; hsa:81858; Q8IXF5; Q8IXF6; Q8N2E7; Q8TB25; Q9BUE4; Q9H0F6" "Neurexins and neuroligins; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6961915596553006747" "False" "High" "IsMasterProtein" "Q9Y6J0" "Calcineurin-binding protein cabin-1 OS=Homo sapiens OX=9606 GN=CABIN1 PE=1 SV=1" "0.005" "False" "2.850" "0" "1" "1" "1" "2220" "246.2" "6.02" "3.48" "1" "cell organization and biogenesis;signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf09047" "23523" "ENSG00000099991" "CABIN1" "G5E9F3; hsa:23523; Q6PHY0; Q9Y460; Q9Y6J0" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Calcium mediated T-cell apoptosis involved in inclusion body myositis" "2" "0" "0.916" "0.796" "1.040" "0.915" "0.787" "0.825" "0.845" "0.822" "1.492" "122.2" "111.9" "97.3" "127.1" "111.8" "96.1" "100.8" "103.3" "100.4" "182.3" "" "" "" "" "" "" "" "" "" "" "108.4" "92.7" "84.9" "95.0" "93.2" "88.3" "85.2" "85.4" "92.1" "182.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5708958418174031723" "False" "High" "IsMasterProtein" "P08574" "Cytochrome c1, heme protein, mitochondrial OS=Homo sapiens OX=9606 GN=CYC1 PE=1 SV=3" "0.005" "False" "2.837" "3" "1" "1" "1" "325" "35.4" "9.00" "3.11" "1" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02167" "1537" "ENSG00000179091" "CYC1" "hsa:1537; P08574; Q5U062; Q6FHS7" "Respiratory electron transport; Mitochondrial protein import" "Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "1.074" "0.979" "1.081" "0.865" "0.902" "1.023" "0.992" "0.997" "0.671" "83.0" "89.1" "81.3" "89.7" "71.8" "74.8" "84.9" "82.3" "82.7" "55.7" "" "" "" "" "" "" "" "" "" "" "73.6" "73.8" "70.9" "67.1" "59.8" "68.7" "71.7" "68.0" "75.9" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4099103662110185134" "False" "High" "IsMasterProtein" "Q08722" "Leukocyte surface antigen CD47 OS=Homo sapiens OX=9606 GN=CD47 PE=1 SV=1" "0.005" "False" "2.835" "3" "1" "1" "1" "323" "35.2" "7.21" "3.36" "1" "cell adhesion;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf04549, Pf08204" "961" "ENSG00000196776" "CD47" "A8K198; D3DN59; hsa:961; Q08722; Q53Y71; Q96A60" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Integrin cell surface interactions; Signal regulatory protein family interactions" "Spinal cord injury; Pleural mesothelioma" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726167102893575460" "False" "High" "IsMasterProtein" "Q7Z4H7" "HAUS augmin-like complex subunit 6 OS=Homo sapiens OX=9606 GN=HAUS6 PE=1 SV=2" "0.005" "False" "2.831" "2" "2" "2" "2" "955" "108.6" "6.47" "4.72" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14661" "54801" "ENSG00000147874" "HAUS6" "B3KPK4; B4DX82; hsa:54801; Q05CG1; Q14CB6; Q14CD9; Q2TA91; Q6IQ10; Q6NZX5; Q7Z4H7; Q8IZQ4; Q96FN0; Q9H950; Q9H998; Q9HCJ8; Q9NXT8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "2.934" "0.869" "1.736" "1.489" "1.860" "1.450" "0.912" "1.418" "0.971" "85.0" "249.5" "73.9" "147.6" "126.6" "158.1" "123.2" "77.6" "120.5" "82.6" "" "" "" "" "" "" "" "" "" "" "75.4" "206.6" "64.5" "110.4" "105.5" "145.2" "104.1" "64.1" "110.5" "82.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4171853106673834253" "False" "High" "IsMasterProtein" "Q9BVV6" "Protein TALPID3 OS=Homo sapiens OX=9606 GN=KIAA0586 PE=1 SV=4" "0.005" "False" "2.821" "1" "1" "1" "1" "1533" "169.2" "5.54" "2.27" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf15324" "9786" "ENSG00000100578" "KIAA0586" "B4DZB6; E7EWM8; hsa:9786; J3KQH9; O60328; Q6NYC6; Q6UV20; Q9BVV6" "" "Joubert syndrome; Ciliopathies" "2" "0" "1.646" "0.875" "0.829" "3.577" "1.564" "1.416" "0.798" "1.091" "4.180" "24.3" "40.0" "21.3" "20.2" "87.0" "38.0" "34.4" "19.4" "26.5" "101.6" "" "" "" "" "" "" "" "" "" "" "21.6" "33.2" "18.6" "15.1" "72.5" "34.9" "29.1" "16.0" "24.3" "101.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8382975367682905247" "False" "High" "IsMasterProtein" "Q8N819" "Probable protein phosphatase 1N OS=Homo sapiens OX=9606 GN=PPM1N PE=2 SV=2" "0.005" "False" "2.820" "2" "1" "1" "1" "430" "46.1" "6.62" "2.71" "1" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "147699" "ENSG00000213889" "PPM1N" "hsa:147699; Q6P662; Q8N819" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-104196132274101736" "False" "High" "IsMasterProtein" "Q9GZT4" "Serine racemase OS=Homo sapiens OX=9606 GN=SRR PE=1 SV=1" "0.005" "False" "2.818" "3" "1" "1" "1" "340" "36.5" "6.54" "2.60" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00291" "63826" "ENSG00000167720" "SRR" "D3DTI5; hsa:63826; Q6IA55; Q9GZT4" "Serine biosynthesis" "Neuroinflammation and glutamatergic signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5073984553663010392" "False" "High" "IsMasterProtein" "Q86UV5" "Ubiquitin carboxyl-terminal hydrolase 48 OS=Homo sapiens OX=9606 GN=USP48 PE=1 SV=1" "0.005" "False" "2.815" "1" "1" "1" "1" "1035" "119.0" "6.05" "2.50" "1" "protein metabolism" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00443, Pf06337" "84196" "ENSG00000090686" "USP48" "B7ZKS7; hsa:84196; Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q86UV5; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; Q9NXR0" "Ub-specific processing proteases" "" "1" "0" "0.933" "0.851" "0.921" "0.867" "0.902" "0.960" "0.900" "0.867" "1.337" "253.5" "236.5" "215.8" "233.5" "219.9" "228.7" "243.3" "228.1" "219.9" "338.8" "" "" "" "" "" "" "" "" "" "" "224.8" "195.9" "188.3" "174.7" "183.3" "210.1" "205.6" "188.5" "201.7" "338.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1320555261900639847" "False" "High" "IsMasterProtein" "Q9NQV5" "PR domain-containing protein 11 OS=Homo sapiens OX=9606 GN=PRDM11 PE=1 SV=2" "0.006" "False" "2.801" "2" "1" "1" "1" "511" "57.8" "6.18" "2.50" "1" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf21549" "56981" "ENSG00000019485" "PRDM11" "hsa:56981; Q8N9F1; Q9NQV5" "" "11p11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2699841489295617883" "False" "High" "IsMasterProtein" "O15169" "Axin-1 OS=Homo sapiens OX=9606 GN=AXIN1 PE=1 SV=2" "0.006" "False" "2.799" "1" "1" "1" "1" "862" "95.6" "6.96" "3.10" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00615, Pf00778, Pf08833, Pf16646" "8312" "ENSG00000103126" "AXIN1" "hsa:8312; O15169; Q4TT26; Q4TT27; Q86YA7; Q8WVW6; Q96S28" "Degradation of AXIN; Ub-specific processing proteases; Estrogen-dependent gene expression; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Wnt signaling pathway; TGF-beta signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; 8p23.1 copy number variation syndrome; DNA damage response (only ATM dependent)" "42" "0" "1.160" "1.004" "1.044" "0.990" "0.947" "0.854" "1.024" "1.181" "3.112" "43.4" "50.3" "43.5" "45.3" "43.0" "41.1" "37.1" "44.4" "51.2" "135.0" "" "" "" "" "" "" "" "" "" "" "38.5" "41.7" "38.0" "33.9" "35.8" "37.7" "31.3" "36.7" "47.0" "135.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850217669682801799" "False" "High" "IsMasterProtein" "Q9NZD8" "Maspardin OS=Homo sapiens OX=9606 GN=SPG21 PE=1 SV=1" "0.006" "False" "2.788" "3" "1" "1" "1" "308" "34.9" "6.28" "3.04" "1" "signal transduction" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf00561" "51324" "ENSG00000090487" "SPG21" "B4DW44; Q6ZMB6; Q9NZD8" "" "" "0" "0" "1.036" "1.036" "1.017" "0.915" "1.035" "1.174" "0.950" "0.942" "1.813" "95.0" "98.5" "98.4" "96.7" "86.9" "98.4" "111.6" "90.2" "89.5" "172.3" "" "" "" "" "" "" "" "" "" "" "84.3" "81.6" "85.9" "72.3" "72.5" "90.4" "94.3" "74.6" "82.1" "172.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3279265676386753137" "False" "High" "IsMasterProtein" "Q9BXB4" "Oxysterol-binding protein-related protein 11 OS=Homo sapiens OX=9606 GN=OSBPL11 PE=1 SV=2" "0.006" "False" "2.786" "3" "2" "2" "2" "747" "83.6" "7.06" "1.77" "2" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114885" "ENSG00000144909" "OSBPL11" "A8K9I7; hsa:114885; Q9BXB4" "RHOH GTPase cycle" "" "1" "0" "1.006" "0.521" "0.745" "1.081" "1.085" "0.393" "0.010" "0.648" "10.672" "6.6" "6.6" "3.4" "4.9" "7.1" "7.2" "2.6" "0.0" "4.3" "70.5" "" "" "" "" "" "" "" "" "" "" "5.9" "5.5" "3.0" "3.7" "6.0" "6.6" "2.2" "0.0" "3.9" "70.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6530118680274496318" "False" "High" "IsMasterProtein" "Q9UHB7" "AF4/FMR2 family member 4 OS=Homo sapiens OX=9606 GN=AFF4 PE=1 SV=1" "0.006" "False" "2.786" "1" "1" "1" "1" "1163" "127.4" "9.31" "3.05" "1" "stress response;other biological processes" "nucleus;other cell component" "" "Pf05110, Pf18875, Pf18876" "27125" "ENSG00000072364" "AFF4" "B2RP19; B7WPD2; hsa:27125; Q498B2; Q59FB3; Q6P592; Q8TDR1; Q9P0E4; Q9UHB7" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5878749091954707236" "False" "High" "IsMasterProtein" "Q9NXA8" "NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT5 PE=1 SV=2" "0.006" "False" "2.784" "3" "1" "1" "1" "310" "33.9" "8.47" "3.56" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf02146" "23408" "ENSG00000124523" "SIRT5" "B4DFM4; B4DYJ5; F5H5Z9; hsa:23408; Q5T294; Q5T295; Q9NXA8; Q9Y6E6" "Transcriptional activation of mitochondrial biogenesis" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "4" "0" "0.874" "0.920" "0.944" "0.812" "0.913" "0.928" "0.854" "0.884" "1.450" "340.5" "297.7" "313.2" "321.6" "276.5" "310.8" "316.0" "290.9" "300.9" "493.7" "" "" "" "" "" "" "" "" "" "" "302.0" "246.6" "273.3" "240.5" "230.5" "285.5" "267.0" "240.4" "276.0" "493.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8568977254648879240" "False" "High" "IsMasterProtein" "P56715" "Oxygen-regulated protein 1 OS=Homo sapiens OX=9606 GN=RP1 PE=1 SV=1" "0.006" "False" "2.778" "0" "1" "2" "1" "2156" "240.5" "5.80" "4.49" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf03607" "6101" "ENSG00000104237" "RP1" "hsa:6101; P56715" "" "Ciliopathies" "1" "0" "1.094" "0.694" "1.782" "1.139" "0.461" "1.523" "0.948" "0.834" "0.644" "240.9" "263.6" "167.1" "429.2" "274.4" "111.2" "366.9" "228.3" "201.0" "155.1" "" "" "" "" "" "" "" "" "" "" "213.6" "218.4" "145.8" "321.0" "228.8" "102.1" "310.1" "188.7" "184.3" "155.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6684989354278680721" "False" "High" "IsMasterProtein" "P10243" "Myb-related protein A OS=Homo sapiens OX=9606 GN=MYBL1 PE=1 SV=2" "0.006" "False" "2.756" "2" "2" "2" "2" "752" "85.8" "7.12" "4.52" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf07988, Pf09316, Pf13921" "4603" "ENSG00000185697" "MYBL1" "E7EW29; hsa:4603; P10243; Q495F9" "PIWI-interacting RNA (piRNA) biogenesis" "Pre-implantation embryo; Pathways affected in adenoid cystic carcinoma" "3" "0" "0.787" "1.066" "0.921" "0.834" "0.747" "1.005" "0.871" "0.664" "0.476" "228.4" "179.8" "243.4" "210.3" "190.4" "170.7" "229.5" "199.0" "151.6" "108.7" "" "" "" "" "" "" "" "" "" "" "202.6" "148.9" "212.4" "157.3" "158.8" "156.8" "193.9" "164.5" "139.0" "108.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1686564620215186353" "False" "High" "IsMasterProtein" "Q8IY31" "Intraflagellar transport protein 20 homolog OS=Homo sapiens OX=9606 GN=IFT20 PE=1 SV=1" "0.006" "False" "2.751" "11" "1" "1" "1" "132" "15.3" "5.12" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf14931" "90410" "ENSG00000109083" "IFT20" "hsa:90410; J3QL09; Q5GLZ2; Q8IY31; Q9BUG5" "Intraflagellar transport" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR)" "3" "0" "1.118" "0.906" "1.131" "1.153" "1.342" "1.100" "0.911" "1.034" "1.272" "123.7" "138.2" "112.1" "139.9" "142.6" "165.9" "136.1" "112.7" "127.9" "157.3" "" "" "" "" "" "" "" "" "" "" "109.7" "114.5" "97.8" "104.6" "118.9" "152.4" "115.0" "93.1" "117.3" "157.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8470400305204825802" "False" "High" "IsMasterProtein" "Q9Y485" "DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3" "0.006" "False" "2.750" "0" "1" "1" "1" "3027" "337.6" "6.34" "2.82" "1" "other biological processes" "other cell component" "" "Pf00400, Pf12234" "1657" "ENSG00000172869" "DMXL1" "hsa:1657; Q9Y485" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849242953917426165" "False" "High" "IsMasterProtein" "Q9HCD5" "Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2" "0.006" "False" "2.748" "4" "2" "3" "2" "579" "65.5" "9.60" "7.24" "2" "signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "" "57727" "ENSG00000124160" "NCOA5" "B2RTV9; E1P5R0; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5" "" "" "0" "0" "0.956" "0.893" "1.098" "0.927" "0.883" "1.013" "0.892" "0.931" "2.206" "375.3" "358.7" "335.3" "412.1" "348.0" "331.3" "380.0" "334.9" "349.3" "828.0" "" "" "" "" "" "" "" "" "" "" "332.8" "297.1" "292.5" "308.2" "290.2" "304.3" "321.2" "276.8" "320.3" "828.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265591638708801395" "False" "High" "IsMasterProtein" "P62699" "Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1" "0.006" "False" "2.746" "10" "1" "1" "1" "121" "13.8" "7.31" "2.48" "1" "cell cycle OR cell proliferation" "non-structural extracellular;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03226" "51646" "ENSG00000119801" "YPEL5" "D6W568; hsa:51646; P62699; Q65Z97; Q8R174; Q9D6M1; Q9UMX7; Q9Y3C9" "Neutrophil degranulation" "Ciliary landscape" "2" "0" "0.839" "0.862" "0.829" "0.823" "0.825" "0.807" "0.855" "0.929" "0.754" "157.5" "132.1" "135.7" "130.5" "129.6" "129.9" "127.0" "134.7" "146.3" "118.7" "" "" "" "" "" "" "" "" "" "" "139.6" "109.5" "118.4" "97.6" "108.1" "119.3" "107.4" "111.3" "134.2" "118.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849777412656735708" "False" "High" "IsMasterProtein" "Q13190" "Syntaxin-5 OS=Homo sapiens OX=9606 GN=STX5 PE=1 SV=2" "0.006" "False" "2.743" "2" "1" "1" "1" "355" "39.6" "9.16" "3.01" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf05739, Pf11416" "6811" "ENSG00000162236" "STX5" "B2R8T2; F8W8Q9; hsa:6811; Q13190; Q5U0D4; Q7Z3T6; Q9BUG1" "RHOA GTPase cycle; COPI-mediated anterograde transport; RHOC GTPase cycle; RHOG GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Intra-Golgi traffic; COPII-mediated vesicle transport; Cargo concentration in the ER" "Alstrom syndrome" "9" "0" "1.121" "0.957" "1.067" "0.915" "0.835" "0.988" "0.409" "1.019" "11.062" "77.0" "86.3" "73.8" "82.2" "70.5" "64.3" "76.2" "31.5" "78.5" "852.2" "" "" "" "" "" "" "" "" "" "" "68.3" "71.5" "64.4" "61.5" "58.8" "59.1" "64.4" "26.0" "72.0" "852.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6831775040715791940" "False" "High" "IsMasterProtein" "Q15043" "Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3" "0.006" "False" "2.742" "2" "1" "1" "1" "492" "54.2" "5.33" "3.50" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "transporter activity" "Pf02535" "23516" "ENSG00000104635" "SLC39A14" "A6NH98; B4DIW3; B6EU88; D3DSR4; hsa:23516; Q15043; Q6ZME8; Q96BB3" "Zinc influx into cells by the SLC39 gene family" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis" "5" "0" "0.891" "0.821" "1.061" "0.743" "0.953" "1.089" "0.871" "1.004" "0.753" "51.2" "45.6" "42.1" "54.3" "38.0" "48.8" "55.8" "44.6" "51.4" "38.5" "" "" "" "" "" "" "" "" "" "" "45.4" "37.8" "36.7" "40.6" "31.7" "44.8" "47.1" "36.9" "47.1" "38.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2756715641617958921" "False" "High" "IsMasterProtein" "Q8N0T1" "Ribosomal biogenesis factor OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=4" "0.007" "False" "2.740" "8" "1" "1" "1" "100" "11.4" "10.46" "2.37" "1" "other biological processes" "cytosol;nucleus" "" "Pf15679" "401466" "ENSG00000176731" "RBIS" "B2RXE7; E5RFW5; hsa:401466; Q8N0T1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4253585410806837271" "False" "High" "IsMasterProtein" "Q8TEU7" "Rap guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=RAPGEF6 PE=1 SV=2" "0.007" "False" "2.730" "1" "1" "1" "1" "1601" "179.3" "6.40" "4.70" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf00595, Pf00617, Pf00618, Pf00788" "51735" "ENSG00000158987" "RAPGEF6" "A3KN82; A5PLL6; B7ZML2; E9PDV7; hsa:51735; Q8NI21; Q8TEU6; Q8TEU7; Q96PC1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7884358778793776870" "False" "High" "IsMasterProtein" "P61968" "LIM domain transcription factor LMO4 OS=Homo sapiens OX=9606 GN=LMO4 PE=1 SV=1" "0.007" "False" "2.729" "5" "1" "1" "1" "165" "18.0" "8.34" "2.77" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00412" "8543" "ENSG00000143013" "LMO4" "D3DT23; hsa:8543; O00158; O88894; P61968" "" "" "0" "0" "1.030" "1.068" "1.091" "1.034" "1.196" "0.980" "0.986" "1.198" "0.937" "128.8" "132.6" "137.5" "140.5" "133.2" "154.0" "126.3" "127.0" "154.4" "120.7" "" "" "" "" "" "" "" "" "" "" "114.2" "109.9" "120.0" "105.1" "111.1" "141.5" "106.7" "105.0" "141.6" "120.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066361306401497810" "False" "High" "IsMasterProtein" "Q9BYK8" "3'-5' exoribonuclease HELZ2 OS=Homo sapiens OX=9606 GN=HELZ2 PE=1 SV=7" "0.007" "False" "2.729" "0" "1" "1" "1" "2896" "322.1" "8.00" "2.54" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf13086, Pf13087" "85441" "ENSG00000130589" "HELZ2" "hsa:85441; Q3C2G2; Q4VXQ1; Q8TEF3; Q96ND3; Q9BYK8; Q9C094" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7245763616426795722" "False" "High" "IsMasterProtein" "Q9NZ01" "Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1" "0.007" "False" "2.723" "3" "1" "1" "1" "308" "36.0" "9.45" "3.33" "1" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02544, Pf21696" "9524" "ENSG00000099797" "TECR" "B2RD55; hsa:9524; O75350; Q6IBB2; Q9BWK3; Q9NZ01; Q9Y6P0" "Synthesis of very long-chain fatty acyl-CoAs" "Fragile X syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7158809287201110390" "False" "High" "IsMasterProtein" "P49069" "Guided entry of tail-anchored proteins factor CAMLG OS=Homo sapiens OX=9606 GN=CAMLG PE=1 SV=1" "0.007" "False" "2.722" "3" "1" "1" "1" "296" "32.9" "8.05" "2.48" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf14963" "819" "ENSG00000164615" "CAMLG" "A1L3Y3; hsa:819; P49069" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4523717261131920154" "False" "High" "IsMasterProtein" "Q8NEZ4" "Histone-lysine N-methyltransferase 2C OS=Homo sapiens OX=9606 GN=KMT2C PE=1 SV=3" "0.007" "False" "2.716" "0" "1" "1" "1" "4911" "541.0" "6.49" "2.46" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "58508" "ENSG00000055609" "KMT2C" "hsa:58508; Q8NC02; Q8NDF6; Q8NEZ4; Q9H9P4; Q9NR13; Q9P222; Q9UDR7" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines" "Histone modifications; Pathways affected in adenoid cystic carcinoma; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; Kleefstra syndrome" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.007" "False" "2.713" "2" "1" "1" "1" "507" "55.0" "7.72" "2.19" "1" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Basigin interactions; Tryptophan catabolism; Amino acid transport across the plasma membrane" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714438533049162384" "False" "High" "IsMasterProtein" "O94953" "Lysine-specific demethylase 4B OS=Homo sapiens OX=9606 GN=KDM4B PE=1 SV=4" "0.007" "False" "2.703" "3" "2" "2" "2" "1096" "121.8" "7.09" "1.94" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23030" "ENSG00000127663" "KDM4B" "B9EGN8; D6W631; hsa:23030; O75274; O94953; Q6P3R5; Q9P1V1; Q9UF40" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones" "" "3" "0" "0.947" "0.878" "0.998" "1.039" "1.130" "0.979" "1.061" "0.976" "0.978" "376.9" "356.8" "330.8" "376.1" "391.7" "425.9" "368.9" "400.0" "367.8" "368.6" "" "" "" "" "" "" "" "" "" "" "334.2" "295.5" "288.6" "281.3" "326.7" "391.2" "311.8" "330.6" "337.3" "368.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2459331660579063458" "False" "High" "IsMasterProtein" "Q9UG56" "Phosphatidylserine decarboxylase proenzyme, mitochondrial OS=Homo sapiens OX=9606 GN=PISD PE=1 SV=4" "0.007" "False" "2.696" "2" "1" "1" "1" "409" "46.6" "9.42" "2.12" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02666" "23761" "ENSG00000241878" "PISD" "B1AKM7; hsa:23761; O43207; O95535; Q6IC28; Q96GQ2; Q9UG56; Q9UGA9" "Synthesis of PE" "Kennedy pathway from sphingolipids; Glycerolipids and glycerophospholipids" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209502681101224333" "False" "High" "IsMasterProtein" "Q9NV96" "Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1" "0.007" "False" "2.670" "2" "1" "1" "1" "361" "40.7" "8.59" "3.64" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03381" "55754" "ENSG00000112697" "TMEM30A" "A8K9V8; E1P539; hsa:55754; Q658Z3; Q96H09; Q9NSL9; Q9NV96" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3616697204810627604" "False" "High" "IsMasterProtein" "Q6ZQX7" "Protein LIAT1 OS=Homo sapiens OX=9606 GN=LIAT1 PE=1 SV=2" "0.007" "False" "2.669" "22" "1" "1" "1" "453" "49.6" "7.97" "2.96" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "" "400566" "ENSG00000187624; ENSG00000283985" "LIAT1" "A5D8T6; hsa:400566; Q6NSI2; Q6PFW9; Q6ZQX7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6402143089739609151" "False" "High" "IsMasterProtein" "Q15070" "Mitochondrial inner membrane protein OXA1L OS=Homo sapiens OX=9606 GN=OXA1L PE=1 SV=4" "0.007" "False" "2.669" "3" "1" "1" "1" "435" "48.5" "9.45" "0.00" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "translation activity;other molecular function" "Pf02096" "5018" "ENSG00000155463" "OXA1L" "A0A087X0L7; B4DPA2; hsa:5018; Q15070" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6433656674866761849" "False" "High" "IsMasterProtein" "Q8NE65" "Zinc finger protein 738 OS=Homo sapiens OX=9606 GN=ZNF738 PE=1 SV=2" "0.007" "False" "2.664" "3" "1" "1" "1" "375" "43.8" "9.06" "3.65" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "" "ENSG00000172687" "ZNF738" "A8K4N7; Q8NE65" "Generic Transcription Pathway" "" "1" "0" "1.101" "0.864" "0.922" "0.899" "0.854" "0.922" "0.614" "0.961" "6.487" "108.3" "119.2" "93.6" "99.9" "97.3" "92.4" "99.9" "66.5" "104.1" "702.4" "" "" "" "" "" "" "" "" "" "" "96.0" "98.7" "81.7" "74.7" "81.1" "84.9" "84.4" "55.0" "95.5" "702.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199691320641439357" "False" "High" "IsMasterProtein" "Q9Y2M5" "Kelch-like protein 20 OS=Homo sapiens OX=9606 GN=KLHL20 PE=1 SV=4" "0.007" "False" "2.644" "2" "2" "2" "2" "609" "67.9" "6.87" "5.06" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00651, Pf01344, Pf07707" "27252" "ENSG00000076321" "KLHL20" "B3KMA0; B4DUR0; hsa:27252; Q5TZF2; Q5ZF45; Q9H457; Q9Y2M5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3798154804985713391" "False" "High" "IsMasterProtein" "P41229" "Lysine-specific demethylase 5C OS=Homo sapiens OX=9606 GN=KDM5C PE=1 SV=2" "0.007" "False" "2.643" "1" "1" "1" "1" "1560" "175.6" "5.58" "1.79" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf01388, Pf02373, Pf02375, Pf02928, Pf08429, Pf21323" "8242" "ENSG00000126012" "KDM5C" "B0QZ44; B4E3I2; F5H3T1; hsa:8242; P41229; Q5JUX3; Q5JUX4; Q5JUX5; Q7Z5S5" "HDMs demethylate histones" "Clear cell renal cell carcinoma pathways" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8031484626058031483" "False" "High" "IsMasterProtein" "Q96RV3" "Pecanex-like protein 1 OS=Homo sapiens OX=9606 GN=PCNX1 PE=1 SV=2" "0.007" "False" "2.642" "1" "1" "1" "1" "2341" "258.5" "7.21" "2.57" "1" "" "other membranes" "" "Pf05041" "22990" "ENSG00000100731" "PCNX1" "B2RTR6; hsa:22990; O94897; Q96AI7; Q96RV3; Q9Y2J9" "" "" "0" "0" "1.280" "1.056" "0.904" "0.890" "0.818" "0.822" "0.995" "1.098" "0.525" "19.7" "25.2" "20.8" "17.8" "17.5" "16.1" "16.2" "19.6" "21.6" "10.3" "" "" "" "" "" "" "" "" "" "" "17.5" "20.9" "18.1" "13.3" "14.6" "14.8" "13.7" "16.2" "19.8" "10.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3193827358447086587" "False" "High" "IsMasterProtein" "P20936" "Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1" "0.007" "False" "2.642" "1" "2" "2" "2" "1047" "116.3" "6.54" "2.27" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00616" "5921" "ENSG00000145715" "RASA1" "B2R6W3; B4DTL2; hsa:5921; P20936; Q68CU6; Q9UDI1" "Regulation of RAS by GAPs; EPHB-mediated forward signaling; Downstream signal transduction; VEGFR2 mediated cell proliferation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "Androgen receptor network in prostate cancer; PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; PDGFR-beta pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; GDNF signaling; EPO receptor signaling" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084706410207598962" "False" "High" "IsMasterProtein" "Q9BVT8" "Transmembrane and ubiquitin-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TMUB1 PE=1 SV=1" "0.007" "False" "2.635" "5" "1" "1" "1" "246" "26.2" "5.72" "3.93" "1" "" "plasma membrane;other membranes;cytoskeleton;nucleus;other cytoplasmic organelle" "" "Pf00240" "83590" "ENSG00000164897" "TMUB1" "D3DX06; hsa:83590; Q53AQ2; Q9BVT8" "" "" "0" "0" "0.820" "0.820" "1.159" "0.803" "0.825" "0.873" "0.810" "0.798" "0.982" "131.0" "107.5" "107.4" "151.8" "105.2" "108.0" "114.3" "106.1" "104.5" "128.7" "" "" "" "" "" "" "" "" "" "" "116.2" "89.0" "93.7" "113.5" "87.7" "99.2" "96.6" "87.7" "95.8" "128.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3192969394575095847" "False" "High" "IsMasterProtein" "Q9BT17" "Mitochondrial ribosome-associated GTPase 1 OS=Homo sapiens OX=9606 GN=MTG1 PE=1 SV=2" "0.007" "False" "2.634" "3" "1" "1" "1" "334" "37.2" "9.47" "3.36" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01926" "92170" "ENSG00000148824" "MTG1" "hsa:92170; Q5VWX8; Q6PIY9; Q8IYJ4; Q8NC48; Q9BT17; Q9BVU8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4516467446471739699" "False" "High" "IsMasterProtein" "Q5T7B8" "Kinesin-like protein KIF24 OS=Homo sapiens OX=9606 GN=KIF24 PE=1 SV=2" "0.007" "False" "2.634" "1" "1" "1" "1" "1368" "151.8" "7.14" "2.01" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00536" "347240" "ENSG00000186638" "KIF24" "hsa:347240; Q2TB93; Q5T7B5; Q5T7B7; Q5T7B8; Q6ZU97; Q6ZUZ2; Q86XZ0; Q9NV43" "Anchoring of the basal body to the plasma membrane" "" "1" "0" "1.061" "1.004" "0.976" "0.972" "0.951" "1.577" "1.332" "1.576" "2.464" "14.6" "15.5" "14.7" "14.3" "14.2" "13.9" "23.1" "19.5" "23.0" "36.0" "" "" "" "" "" "" "" "" "" "" "13.0" "12.9" "12.8" "10.7" "11.9" "12.8" "19.5" "16.1" "21.1" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888739715540464961" "False" "High" "IsMasterProtein" "O60673" "DNA polymerase zeta catalytic subunit OS=Homo sapiens OX=9606 GN=REV3L PE=1 SV=2" "0.007" "False" "2.624" "0" "1" "3" "1" "3130" "352.6" "8.47" "7.31" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260, Pf15735" "5980" "ENSG00000009413" "REV3L" "O43214; O60673; Q5TC33" "Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI" "DNA repair pathways, full network" "4" "0" "1.072" "0.975" "0.979" "1.012" "0.928" "1.002" "1.023" "0.933" "0.532" "360.5" "386.5" "351.6" "353.0" "365.0" "334.7" "361.3" "369.0" "336.5" "192.0" "" "" "" "" "" "" "" "" "" "" "319.7" "320.1" "306.8" "264.0" "304.4" "307.5" "305.4" "305.0" "308.6" "192.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1051800165428971168" "False" "High" "IsMasterProtein" "Q8IZ41" "Ras and EF-hand domain-containing protein OS=Homo sapiens OX=9606 GN=RASEF PE=1 SV=1" "0.007" "False" "2.620" "1" "1" "1" "1" "740" "82.8" "5.11" "2.24" "1" "transport" "cytosol;other cell component" "other molecular function" "Pf00071, Pf13499" "158158" "ENSG00000165105" "RASEF" "A6NC29; hsa:158158; Q8IZ41; Q96N04" "" "" "0" "0" "0.894" "0.903" "0.922" "0.857" "0.880" "1.053" "1.006" "0.971" "0.448" "327.9" "293.0" "296.1" "302.3" "281.1" "288.5" "345.3" "329.9" "318.5" "146.9" "" "" "" "" "" "" "" "" "" "" "290.8" "242.7" "258.3" "226.1" "234.4" "265.1" "291.8" "272.7" "292.1" "146.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7880695163940437874" "False" "High" "IsMasterProtein" "Q9Y580" "RNA-binding protein 7 OS=Homo sapiens OX=9606 GN=RBM7 PE=1 SV=1" "0.007" "False" "2.604" "4" "1" "1" "1" "266" "30.5" "9.57" "0.00" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "10179" "ENSG00000076053" "RBM7" "B2R6K8; hsa:10179; Q9NUT4; Q9Y580" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8244931832406879896" "False" "High" "IsMasterProtein" "P78424" "POU domain, class 6, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU6F2 PE=1 SV=3" "0.007" "False" "2.573" "1" "1" "4" "1" "691" "73.2" "7.77" "10.83" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "11281" "ENSG00000106536" "POU6F2" "A4D1W2; C4AMB9; hsa:11281; P78424; P78425; Q75ME8; Q86UM6; Q9UDS7" "" "" "0" "0" "1.035" "0.905" "1.101" "1.007" "0.973" "1.124" "1.005" "0.732" "1.286" "444.1" "459.5" "402.0" "488.9" "447.4" "432.2" "499.2" "446.4" "325.1" "570.9" "" "" "" "" "" "" "" "" "" "" "393.8" "380.7" "350.8" "365.6" "373.1" "397.0" "421.9" "369.0" "298.2" "570.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8526861795692287608" "False" "High" "IsMasterProtein" "Q6PK04" "Coiled-coil domain-containing protein 137 OS=Homo sapiens OX=9606 GN=CCDC137 PE=1 SV=1" "0.007" "False" "2.571" "3" "1" "1" "1" "289" "33.2" "10.93" "3.52" "1" "" "nucleus;other cell component" "" "" "339230" "ENSG00000185298" "CCDC137" "hsa:339230; Q6PK04" "" "" "0" "0" "1.005" "0.941" "1.004" "0.999" "0.936" "0.860" "0.802" "0.871" "0.534" "356.8" "358.4" "335.7" "358.3" "356.5" "334.1" "307.0" "286.2" "310.7" "190.5" "" "" "" "" "" "" "" "" "" "" "316.4" "296.9" "292.9" "267.9" "297.3" "306.9" "259.4" "236.6" "284.9" "190.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7330317437977039095" "False" "High" "IsMasterProtein" "Q15431" "Synaptonemal complex protein 1 OS=Homo sapiens OX=9606 GN=SYCP1 PE=1 SV=2" "0.008" "False" "2.565" "1" "2" "2" "1" "976" "114.1" "5.96" "5.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf05483" "6847" "ENSG00000198765" "SYCP1" "hsa:6847; O14963; Q15431; Q5VXJ6" "Meiotic synapsis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6157153298590242054" "False" "High" "IsMasterProtein" "Q8IZQ5" "Selenoprotein H OS=Homo sapiens OX=9606 GN=SELENOH PE=1 SV=2" "0.008" "False" "2.537" "7" "1" "1" "1" "122" "13.4" "9.74" "3.14" "1" "" "ER/Golgi" "" "Pf10262" "280636" "ENSG00000211450" "SELENOH" "hsa:280636; Q8IZQ5; Q8N672" "" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3999594216140566415" "False" "High" "IsMasterProtein" "P83369" "U7 snRNA-associated Sm-like protein LSm11 OS=Homo sapiens OX=9606 GN=LSM11 PE=1 SV=2" "0.008" "False" "2.535" "3" "1" "1" "1" "360" "39.5" "10.99" "2.95" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "" "134353" "ENSG00000155858" "LSM11" "A0AVQ1; hsa:134353; P83369; Q7Z7P0; Q8N975" "RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012915059673315434" "False" "High" "IsMasterProtein" "Q9UBK8" "Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4" "0.008" "False" "2.526" "3" "2" "3" "1" "698" "77.6" "6.49" "7.88" "2" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00175, Pf00258, Pf00667" "4552" "ENSG00000124275" "MTRR" "hsa:4552; O60471; Q32MA9; Q7Z4M8; Q9UBK8" "Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Male infertility; Spina bifida" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6197247688658885913" "False" "High" "IsMasterProtein" "Q8N1B4" "Vacuolar protein sorting-associated protein 52 homolog OS=Homo sapiens OX=9606 GN=VPS52 PE=1 SV=1" "0.008" "False" "2.525" "1" "1" "1" "1" "723" "82.2" "5.99" "2.87" "1" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04129, Pf20655" "6293" "ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590; ENSG00000228425; ENSG00000236014" "VPS52" "A2BF38; B0UZZ4; B4DNI9; hsa:6293; Q53GR4; Q5JPA0; Q5SQW1; Q8IUN6; Q8N1B4; Q9NPT5" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.054" "0.949" "1.226" "0.937" "1.051" "1.050" "0.812" "0.968" "4.963" "90.1" "95.0" "85.5" "110.5" "84.5" "94.7" "94.6" "73.2" "87.2" "447.2" "" "" "" "" "" "" "" "" "" "" "79.9" "78.7" "74.6" "82.6" "70.4" "87.0" "79.9" "60.5" "80.0" "447.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-663031508343712048" "False" "High" "IsMasterProtein" "P06681" "Complement C2 OS=Homo sapiens OX=9606 GN=C2 PE=1 SV=2" "0.008" "False" "2.516" "2" "1" "1" "1" "752" "83.2" "7.42" "2.80" "1" "protein metabolism;stress response;other biological processes" "non-structural extracellular" "other molecular function" "Pf00084, Pf00089, Pf00092" "717" "ENSG00000166278; ENSG00000204364; ENSG00000206372; ENSG00000226560; ENSG00000231543; ENSG00000235017; ENSG00000235696" "C2" "B4DPF3; B4DV20; E9PFN7; hsa:717; O19694; P06681; Q13904" "Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5" "Allograft rejection; Complement system; Dengue-2 interactions with complement and coagulation cascades; Oxidative damage response; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades" "10" "0" "1.037" "1.035" "1.070" "1.068" "0.948" "0.913" "1.089" "1.053" "0.490" "84.5" "87.6" "87.5" "90.4" "90.2" "80.1" "77.1" "92.0" "89.0" "41.4" "" "" "" "" "" "" "" "" "" "" "74.9" "72.6" "76.3" "67.6" "75.2" "73.6" "65.2" "76.0" "81.6" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2438829351584223840" "False" "High" "IsMasterProtein" "O75529" "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L OS=Homo sapiens OX=9606 GN=TAF5L PE=1 SV=1" "0.008" "False" "2.506" "2" "1" "1" "1" "589" "66.1" "5.88" "3.29" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "27097" "ENSG00000135801" "TAF5L" "hsa:27097; O75529; Q5TDI5; Q5TDI6; Q8IW31" "HATs acetylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "462571488104407495" "False" "High" "IsMasterProtein" "Q86T24" "Transcriptional regulator Kaiso OS=Homo sapiens OX=9606 GN=ZBTB33 PE=1 SV=2" "0.008" "False" "2.495" "2" "1" "1" "1" "672" "74.4" "5.12" "2.86" "1" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "10009" "ENSG00000177485" "ZBTB33" "B2R5U6; hsa:10009; O00319; Q7Z361; Q86T24; Q8IVP6; Q8N3P0" "" "Wnt signaling pathway and pluripotency" "1" "0" "0.888" "1.801" "1.090" "1.003" "0.673" "0.759" "0.824" "1.043" "1.624" "61.3" "54.4" "110.4" "66.8" "61.5" "41.3" "46.5" "50.5" "63.9" "99.5" "" "" "" "" "" "" "" "" "" "" "54.3" "45.1" "96.3" "49.9" "51.3" "37.9" "39.3" "41.7" "58.6" "99.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7272269523816723745" "False" "High" "IsMasterProtein" "Q13613" "Myotubularin-related protein 1 OS=Homo sapiens OX=9606 GN=MTMR1 PE=1 SV=4" "0.008" "False" "2.483" "1" "1" "1" "1" "665" "74.6" "7.14" "0.00" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf02893, Pf06602" "8776" "ENSG00000063601" "MTMR1" "A0A024RC07; hsa:8776; Q13613; Q9UBX6; Q9UEM0; Q9UQD5" "RHOF GTPase cycle; Synthesis of PIPs at the plasma membrane" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1778279976446885041" "False" "High" "IsMasterProtein" "P04733" "Metallothionein-1F OS=Homo sapiens OX=9606 GN=MT1F PE=1 SV=1" "0.008" "False" "2.482" "20" "1" "3" "1" "61" "6.1" "7.83" "0.00" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4494" "ENSG00000198417" "MT1F" "hsa:4494; P04733; Q9UI97" "Metallothioneins bind metals" "Copper homeostasis; Zinc homeostasis" "3" "0" "1.721" "1.023" "1.752" "1.539" "1.010" "1.603" "1.337" "0.996" "0.537" "126.9" "218.4" "129.8" "222.3" "195.3" "128.2" "203.4" "169.7" "126.4" "68.2" "" "" "" "" "" "" "" "" "" "" "112.5" "180.9" "113.2" "166.3" "162.8" "117.8" "171.9" "140.2" "115.9" "68.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3308081350103847019" "False" "High" "IsMasterProtein" "P61218" "DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Homo sapiens OX=9606 GN=POLR2F PE=1 SV=1" "0.008" "False" "2.482" "11" "2" "3" "2" "127" "14.5" "4.22" "7.74" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01192" "5435" "ENSG00000100142" "POLR2F" "hsa:5435; P41584; P61218; Q6IAY3" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM" "Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "56" "0" "0.884" "0.977" "0.877" "0.899" "0.977" "0.830" "0.809" "0.791" "0.646" "455.2" "402.4" "444.6" "399.1" "409.4" "444.9" "377.9" "368.4" "359.9" "294.1" "" "" "" "" "" "" "" "" "" "" "403.7" "333.3" "387.9" "298.5" "341.4" "408.7" "319.4" "304.5" "330.1" "294.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2230295239776997928" "False" "High" "IsMasterProtein" "Q969W3" "Protein VCF1 OS=Homo sapiens OX=9606 GN=VCF1 PE=1 SV=2" "0.008" "False" "2.480" "5" "1" "2" "1" "186" "19.5" "11.27" "5.74" "1" "" "" "" "Pf15434" "84923" "ENSG00000133193" "VCF1" "B4E339; hsa:84923; Q969W3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1391272447933749932" "False" "High" "IsMasterProtein" "Q9UNI6" "Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1" "0.008" "False" "2.476" "4" "1" "1" "1" "340" "37.7" "6.84" "0.00" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00782" "11266" "ENSG00000081721" "DUSP12" "hsa:11266; Q5VXA8; Q9UNI6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1991915273317640998" "False" "High" "IsMasterProtein" "O00463" "TNF receptor-associated factor 5 OS=Homo sapiens OX=9606 GN=TRAF5 PE=1 SV=2" "0.008" "False" "2.476" "2" "1" "1" "1" "557" "64.4" "7.43" "3.75" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf21355, Pf21363" "7188" "ENSG00000082512" "TRAF5" "B4DIS9; B4E0A2; hsa:7188; O00463; Q6FHY1" "" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; 1p36 copy number variation syndrome; 13q12.12 copy number variation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190496341580409730" "False" "High" "IsMasterProtein" "Q5TAX3" "Terminal uridylyltransferase 4 OS=Homo sapiens OX=9606 GN=TUT4 PE=1 SV=3" "0.008" "False" "2.474" "1" "2" "2" "2" "1644" "185.0" "7.97" "4.43" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf01909, Pf03828, Pf19088" "23318" "ENSG00000134744" "TUT4" "A2RRP0; B7Z8J5; D3DQ35; hsa:23318; Q12764; Q5TAX2; Q5TAX3; Q5TAX4; Q86XZ3" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "3" "0" "1.518" "0.979" "1.942" "1.391" "0.815" "1.698" "1.428" "0.974" "0.610" "53.7" "81.5" "52.5" "104.2" "74.6" "43.7" "91.1" "76.6" "52.2" "32.7" "" "" "" "" "" "" "" "" "" "" "47.6" "67.5" "45.8" "77.9" "62.2" "40.2" "77.0" "63.3" "47.9" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6977987857049713242" "False" "High" "IsMasterProtein" "Q14159" "DNA repair-scaffolding protein OS=Homo sapiens OX=9606 GN=SPIDR PE=1 SV=2" "0.008" "False" "2.459" "2" "1" "1" "1" "915" "100.3" "6.62" "2.23" "1" "DNA metabolism;stress response;other biological processes" "nucleus" "" "Pf14950, Pf14951" "23514" "ENSG00000164808" "SPIDR" "B4DFV2; B4E0Y6; hsa:23514; Q14159; Q96BI5" "Resolution of D-loop Structures through Holliday Junction Intermediates" "Primary ovarian insufficiency" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "High" "1" "" "-3070886706511762615" "False" "High" "IsMasterProtein" "Q6PJW8" "Consortin OS=Homo sapiens OX=9606 GN=CNST PE=1 SV=3" "0.008" "False" "2.457" "1" "1" "1" "1" "725" "79.5" "4.53" "3.69" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf15281" "163882" "ENSG00000162852" "CNST" "hsa:163882; Q5VSY9; Q5VTM7; Q6PJW8; Q8IYA9; Q8N3L5; Q8NB09; Q8TEI2; Q96MR5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4330254005621380904" "False" "High" "IsMasterProtein" "Q96BT3" "Centromere protein T OS=Homo sapiens OX=9606 GN=CENPT PE=1 SV=2" "0.008" "False" "2.452" "2" "1" "1" "1" "561" "60.4" "6.58" "3.15" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511, Pf16171" "80152" "ENSG00000102901" "CENPT" "hsa:80152; Q96BT3; Q96I29; Q96IC6; Q96NK9; Q9H901" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "" "7" "0" "0.900" "0.810" "1.109" "0.799" "0.826" "0.820" "0.980" "0.862" "0.736" "58.3" "52.5" "47.3" "64.7" "46.6" "48.2" "47.8" "57.2" "50.3" "42.9" "" "" "" "" "" "" "" "" "" "" "51.7" "43.5" "41.2" "48.4" "38.9" "44.3" "40.4" "47.2" "46.1" "42.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7423866606079625647" "False" "High" "IsMasterProtein" "Q9Y3M8" "StAR-related lipid transfer protein 13 OS=Homo sapiens OX=9606 GN=STARD13 PE=1 SV=2" "0.008" "False" "2.450" "1" "1" "1" "1" "1113" "124.9" "7.02" "2.32" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf01852, Pf07647" "90627" "ENSG00000133121" "STARD13" "A2A309; A2A310; hsa:90627; Q5HYH1; Q5TAE3; Q6UN61; Q86TP6; Q86WQ3; Q86XT1; Q9Y3M8" "CDC42 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542361950198791017" "False" "High" "IsMasterProtein" "Q96T21" "Selenocysteine insertion sequence-binding protein 2 OS=Homo sapiens OX=9606 GN=SECISBP2 PE=1 SV=2" "0.008" "False" "2.447" "1" "1" "1" "1" "854" "95.4" "8.12" "2.25" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "79048" "ENSG00000187742" "SECISBP2" "F8W892; hsa:79048; Q5HYY1; Q7L1Z0; Q8IYC0; Q96T21; Q9H0A1" "Selenocysteine synthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1258287404599916769" "False" "High" "IsMasterProtein" "P43251" "Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2" "0.008" "False" "2.432" "2" "1" "1" "1" "543" "61.1" "6.25" "2.03" "1" "other metabolic processes;developmental processes" "non-structural extracellular;mitochondrion" "other molecular function" "Pf00795, Pf19018" "686" "ENSG00000169814" "BTD" "A6NHF2; B2R865; B4DFX1; B4DLJ9; B7Z7C9; F8W1Q3; hsa:686; P43251; Q96EM9" "Biotin transport and metabolism; Defective BTD causes biotidinase deficiency" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233770781209120367" "False" "High" "IsMasterProtein" "Q9H5J0" "Zinc finger and BTB domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZBTB3 PE=1 SV=1" "0.008" "False" "2.429" "2" "2" "2" "2" "574" "61.8" "5.62" "2.40" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "" "ENSG00000185670" "ZBTB3" "Q9H5J0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709951686369221452" "False" "High" "IsMasterProtein" "Q9Y600" "Cysteine sulfinic acid decarboxylase OS=Homo sapiens OX=9606 GN=CSAD PE=1 SV=2" "0.008" "False" "2.426" "2" "1" "1" "1" "493" "55.0" "6.48" "2.44" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00282" "51380" "ENSG00000139631" "CSAD" "A8K0U4; hsa:51380; Q4QQH9; Q9UNJ5; Q9Y600; Q9Y601" "Degradation of cysteine and homocysteine" "Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8150388100330610211" "False" "High" "IsMasterProtein" "Q96HP0" "Dedicator of cytokinesis protein 6 OS=Homo sapiens OX=9606 GN=DOCK6 PE=1 SV=3" "0.008" "False" "2.425" "0" "1" "1" "1" "2047" "229.4" "6.74" "2.84" "1" "signal transduction" "cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "57572" "ENSG00000130158" "DOCK6" "A6H8X5; hsa:57572; Q7Z7P4; Q96HP0; Q9P2F2" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle" "Genetic causes of porto-sinusoidal vascular disease" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1384123657554198198" "False" "High" "IsMasterProtein" "Q8NHQ9" "ATP-dependent RNA helicase DDX55 OS=Homo sapiens OX=9606 GN=DDX55 PE=1 SV=3" "0.008" "False" "2.425" "1" "1" "1" "1" "600" "68.5" "9.25" "2.30" "1" "" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf13959" "57696" "ENSG00000111364" "DDX55" "hsa:57696; Q658L6; Q8IYH0; Q8NHQ9; Q9HCH7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415946790012265046" "False" "High" "IsMasterProtein" "O75586" "Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2" "0.008" "False" "2.424" "4" "1" "1" "1" "246" "28.4" "8.62" "3.15" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04934" "10001" "ENSG00000133997" "MED6" "B4DU17; B4E2P0; hsa:10001; O15401; O75586; Q53FE3; Q53HJ3; Q6FHQ4; Q9BTH1; Q9UHL1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.311" "0.719" "1.097" "0.861" "0.888" "1.058" "0.567" "0.837" "4.132" "88.6" "116.2" "63.7" "97.2" "76.3" "78.7" "93.8" "50.2" "74.2" "366.3" "" "" "" "" "" "" "" "" "" "" "78.6" "96.3" "55.6" "72.7" "63.7" "72.3" "79.2" "41.5" "68.1" "366.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6585156526220186140" "False" "High" "IsMasterProtein" "Q13610" "Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1" "0.008" "False" "2.422" "1" "1" "1" "1" "501" "55.8" "4.77" "3.07" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400" "11137" "ENSG00000136045" "PWP1" "A8K3R6; hsa:11137; Q13610; Q7Z3X9" "" "" "0" "0" "0.902" "0.835" "0.924" "0.850" "0.974" "0.973" "0.887" "0.779" "1.602" "105.0" "94.7" "87.6" "97.0" "89.3" "102.2" "102.1" "93.1" "81.8" "168.2" "" "" "" "" "" "" "" "" "" "" "93.1" "78.4" "76.4" "72.6" "74.4" "93.9" "86.3" "77.0" "75.0" "168.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3046648171145395008" "False" "High" "IsMasterProtein" "Q8NC42" "E3 ubiquitin-protein ligase RNF149 OS=Homo sapiens OX=9606 GN=RNF149 PE=1 SV=2" "0.009" "False" "2.400" "4" "1" "1" "1" "400" "43.1" "6.54" "2.91" "1" "protein metabolism;other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02225, Pf13639" "284996" "ENSG00000163162" "RNF149" "hsa:284996; Q53S14; Q8N5I8; Q8NBY5; Q8NC42; Q8WUU3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2452511729080939995" "False" "High" "IsMasterProtein" "O95159" "Zinc finger protein-like 1 OS=Homo sapiens OX=9606 GN=ZFPL1 PE=1 SV=2" "0.009" "False" "2.397" "3" "1" "1" "1" "310" "34.1" "8.07" "3.07" "1" "transport;other biological processes" "other membranes;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "7542" "ENSG00000162300" "ZFPL1" "A8K7E9; hsa:7542; O14616; O95159; Q9UID0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.009" "False" "2.393" "2" "1" "1" "1" "368" "41.5" "5.43" "2.77" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "Fragile X syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2019204481334339745" "False" "High" "IsMasterProtein" "Q9H3R0" "Lysine-specific demethylase 4C OS=Homo sapiens OX=9606 GN=KDM4C PE=1 SV=2" "0.009" "False" "2.392" "1" "1" "1" "1" "1056" "119.9" "6.46" "3.14" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23081" "ENSG00000107077" "KDM4C" "B4E1Y4; B7ZL46; F5H347; F5H7P0; hsa:23081; O94877; Q2M3M0; Q5JUC9; Q5VYJ2; Q5VYJ3; Q9H3R0" "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HDMs demethylate histones" "" "2" "0" "0.776" "0.941" "0.957" "1.084" "1.114" "1.064" "0.482" "0.931" "5.500" "9.5" "7.4" "9.0" "9.1" "10.3" "10.6" "10.1" "4.6" "8.9" "52.4" "" "" "" "" "" "" "" "" "" "" "8.4" "6.1" "7.8" "6.8" "8.6" "9.7" "8.6" "3.8" "8.1" "52.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2150504765694079773" "False" "High" "IsMasterProtein" "Q4ADV7" "Guanine nucleotide exchange factor subunit RIC1 OS=Homo sapiens OX=9606 GN=RIC1 PE=1 SV=2" "0.009" "False" "2.389" "1" "1" "1" "1" "1423" "159.2" "6.38" "3.26" "1" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf07064" "57589" "ENSG00000107036" "RIC1" "B2RN24; B7ZM67; G5E932; hsa:57589; Q4ADV7; Q4VXJ8; Q4VXJ9; Q76MT5; Q8N6E0; Q8TEH4; Q9H0A5; Q9H9S1" "RAB GEFs exchange GTP for GDP on RABs; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "0.887" "0.941" "0.810" "0.826" "1.012" "1.016" "1.072" "1.094" "1.342" "178.4" "158.2" "167.8" "144.6" "147.3" "180.6" "181.2" "191.2" "195.2" "239.4" "" "" "" "" "" "" "" "" "" "" "158.2" "131.1" "146.4" "108.1" "122.9" "165.9" "153.2" "158.0" "179.0" "239.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3106213779201821222" "False" "High" "IsMasterProtein" "Q8N357" "Solute carrier family 35 member F6 OS=Homo sapiens OX=9606 GN=SLC35F6 PE=1 SV=1" "0.009" "False" "2.385" "3" "1" "1" "1" "371" "40.2" "6.93" "3.18" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf06027" "54978" "ENSG00000213699" "SLC35F6" "D6W543; hsa:54978; Q53GK2; Q8N357; Q8NBX6; Q9NWX0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "948576377760285540" "False" "High" "IsMasterProtein" "Q5PRF9" "Protein Smaug homolog 2 OS=Homo sapiens OX=9606 GN=SAMD4B PE=1 SV=1" "0.009" "False" "2.383" "1" "1" "1" "1" "694" "75.4" "6.83" "2.88" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00536" "55095" "ENSG00000179134" "SAMD4B" "A5Z0M6; hsa:55095; Q5PRF9; Q6P194" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "167158526121610019" "False" "High" "IsMasterProtein" "Q9UPW5" "Cytosolic carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=AGTPBP1 PE=1 SV=3" "0.009" "False" "2.382" "1" "1" "1" "1" "1226" "138.4" "6.15" "2.74" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00246, Pf18027" "23287" "ENSG00000135049" "AGTPBP1" "B4DIT6; B4DRZ8; hsa:23287; Q5VV80; Q63HM7; Q658P5; Q6P9D6; Q9H8U6; Q9H9W8; Q9NVK1; Q9UPW5" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7167041566668473319" "False" "High" "IsMasterProtein" "Q96RK0" "Protein capicua homolog OS=Homo sapiens OX=9606 GN=CIC PE=1 SV=3" "0.009" "False" "2.380" "0" "1" "1" "1" "2517" "257.9" "8.10" "3.18" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf16090" "23152" "ENSG00000079432" "CIC" "A0A7P0T9K5" "" "" "0" "0" "1.090" "0.869" "0.823" "0.965" "1.245" "1.139" "0.977" "1.025" "3.356" "30.4" "33.1" "26.4" "25.0" "29.3" "37.8" "34.6" "29.7" "31.1" "102.0" "" "" "" "" "" "" "" "" "" "" "26.9" "27.4" "23.1" "18.7" "24.5" "34.8" "29.3" "24.5" "28.6" "102.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6944601348442643793" "False" "High" "IsMasterProtein" "Q460N5" "Protein mono-ADP-ribosyltransferase PARP14 OS=Homo sapiens OX=9606 GN=PARP14 PE=1 SV=3" "0.009" "False" "2.377" "1" "2" "2" "2" "1801" "202.7" "7.18" "2.08" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf01661, Pf02825" "54625" "ENSG00000173193" "PARP14" "B4E2H0; hsa:54625; Q460N4; Q460N5; Q8J027; Q9H9X9; Q9NV60; Q9ULF2" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "" "3" "0" "0.997" "0.726" "0.597" "0.767" "0.865" "0.821" "0.541" "0.771" "4.016" "18.8" "18.8" "13.7" "11.2" "14.4" "16.3" "15.5" "10.2" "14.5" "75.6" "" "" "" "" "" "" "" "" "" "" "16.7" "15.6" "11.9" "8.4" "12.0" "15.0" "13.1" "8.4" "13.3" "75.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1427297230371715365" "False" "High" "IsMasterProtein" "Q6UB99" "Ankyrin repeat domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ANKRD11 PE=1 SV=3" "0.009" "False" "2.373" "0" "1" "1" "1" "2663" "297.7" "7.11" "0.00" "1" "developmental processes;other biological processes" "cytosol;nucleus" "" "Pf12796" "29123" "ENSG00000167522" "ANKRD11" "hsa:29123; Q6NTG1; Q6QMF8; Q6UB99" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "High" "High" "High" "Not Found" "High" "1" "" "5043456387620106594" "False" "High" "IsMasterProtein" "Q86US8" "Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2" "0.009" "False" "2.366" "0" "1" "1" "1" "1419" "160.4" "7.05" "2.90" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23293" "ENSG00000070366" "SMG6" "B7Z874; hsa:23293; O94837; Q86US8; Q86VH6; Q9UF60" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "1.001" "0.953" "0.988" "0.842" "0.951" "0.904" "0.882" "0.834" "0.862" "124.9" "125.0" "119.0" "123.4" "105.2" "118.8" "113.0" "110.2" "104.2" "107.7" "" "" "" "" "" "" "" "" "" "" "110.8" "103.5" "103.8" "92.3" "87.7" "109.1" "95.5" "91.1" "95.5" "107.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4635662456929640047" "False" "High" "IsMasterProtein" "O15304" "Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2" "0.009" "False" "2.365" "5" "1" "2" "1" "175" "18.7" "7.61" "4.87" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05458" "10572" "ENSG00000184990" "SIVA1" "hsa:10572; O15304; Q96P98; Q9UPD6" "" "p53 transcriptional gene network" "1" "0" "1.022" "0.958" "1.022" "0.997" "0.984" "1.531" "1.401" "1.546" "3.199" "60.7" "62.1" "58.2" "62.0" "60.6" "59.7" "92.9" "85.0" "93.9" "194.2" "" "" "" "" "" "" "" "" "" "" "53.8" "51.4" "50.8" "46.4" "50.5" "54.9" "78.6" "70.3" "86.1" "194.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3460049962588220827" "False" "High" "IsMasterProtein" "Q96CX2" "BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1" "0.009" "False" "2.363" "2" "1" "1" "1" "325" "35.7" "5.64" "2.58" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02214" "115207" "ENSG00000178695" "KCTD12" "hsa:115207; Q96CX2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2733253045392511170" "False" "High" "IsMasterProtein" "P23297" "Protein S100-A1 OS=Homo sapiens OX=9606 GN=S100A1 PE=1 SV=2" "0.010" "False" "2.359" "7" "1" "1" "1" "94" "10.5" "4.50" "2.88" "1" "signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6271" "ENSG00000160678" "S100A1" "B2R5D9; hsa:6271; P23297; Q5T7Y3" "ER-Phagosome pathway; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5102832271823047499" "False" "High" "IsMasterProtein" "Q8TDG2" "Actin-related protein T1 OS=Homo sapiens OX=9606 GN=ACTRT1 PE=1 SV=2" "0.010" "False" "2.358" "3" "1" "1" "1" "376" "41.7" "6.79" "3.31" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00022" "139741" "ENSG00000123165" "ACTRT1" "hsa:139741; Q6X7C1; Q8TDG2; Q96L10" "" "" "0" "0" "0.831" "0.761" "0.917" "0.823" "0.929" "0.916" "0.886" "0.785" "0.367" "371.0" "308.2" "282.3" "340.0" "305.5" "344.7" "339.8" "328.5" "291.2" "136.2" "" "" "" "" "" "" "" "" "" "" "329.0" "255.3" "246.3" "254.3" "254.7" "316.7" "287.2" "271.6" "267.1" "136.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3837932967956595615" "False" "High" "IsMasterProtein" "Q8N511" "Transmembrane protein 199 OS=Homo sapiens OX=9606 GN=TMEM199 PE=1 SV=1" "0.010" "False" "2.335" "6" "1" "1" "1" "208" "23.1" "9.01" "3.98" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf11712" "147007" "ENSG00000244045" "TMEM199" "hsa:147007; Q8N511" "" "" "0" "0" "1.018" "1.042" "1.100" "1.113" "0.974" "1.055" "1.038" "0.919" "0.539" "179.5" "182.8" "187.0" "197.4" "199.8" "174.9" "189.4" "186.4" "164.9" "96.7" "" "" "" "" "" "" "" "" "" "" "159.2" "151.4" "163.1" "147.7" "166.6" "160.6" "160.1" "154.1" "151.2" "96.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5146194763557846941" "False" "High" "IsMasterProtein" "Q9Y613" "FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3" "0.010" "False" "2.333" "1" "1" "1" "1" "1164" "126.5" "6.39" "3.08" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf18382" "29109" "ENSG00000135723" "FHOD1" "hsa:29109; Q59F76; Q6Y1F2; Q76MS8; Q8N521; Q9Y613" "" "VEGFA-VEGFR2 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3303304153352380892" "False" "High" "IsMasterProtein" "P33527" "Multidrug resistance-associated protein 1 OS=Homo sapiens OX=9606 GN=ABCC1 PE=1 SV=3" "0.010" "False" "2.331" "1" "2" "2" "2" "1531" "171.5" "7.11" "4.98" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00005, Pf00664" "4363" "ENSG00000103222; ENSG00000278183" "ABCC1" "A3RJX2; C9JPJ4; hsa:4363; O14819; O43333; P33527; P78419; Q59GI9; Q9UQ97; Q9UQ99; Q9UQA0" "ABC-family proteins mediated transport; Sphingolipid de novo biosynthesis; Paracetamol ADME; Cytoprotection by HMOX1; Transport of RCbl within the body; NFE2L2 regulating MDR associated enzymes; Heme degradation; Synthesis of Leukotrienes (LT) and Eoxins (EX)" "Irinotecan pathway; Leukotriene metabolic pathway; TROP2 regulatory signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263352969811880337" "False" "High" "IsMasterProtein" "Q13432" "Protein unc-119 homolog A OS=Homo sapiens OX=9606 GN=UNC119 PE=1 SV=1" "0.010" "False" "2.325" "3" "1" "1" "1" "240" "26.9" "6.42" "2.56" "1" "cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05351" "9094" "ENSG00000109103" "UNC119" "A8K8G4; F1T095; hsa:9094; O95126; Q13432" "" "Joubert syndrome; Ciliopathies" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3879752315455634749" "False" "High" "IsMasterProtein" "O43822" "Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1" "0.010" "False" "2.322" "4" "1" "1" "1" "256" "28.3" "7.34" "2.13" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "" "" "755" "ENSG00000160226" "CFAP410" "A8MPS9; O14993; O43822; Q8N5X6; Q99837; Q99838" "" "Ciliopathies; Bardet-Biedl syndrome" "2" "0" "1.064" "0.812" "1.180" "0.890" "1.444" "1.258" "0.287" "0.964" "12.235" "17.9" "19.1" "14.6" "21.2" "16.0" "25.9" "22.6" "5.1" "17.3" "219.5" "" "" "" "" "" "" "" "" "" "" "15.9" "15.8" "12.7" "15.8" "13.3" "23.8" "19.1" "4.2" "15.9" "219.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6897785543843873721" "False" "High" "IsMasterProtein" "Q7Z5J4" "Retinoic acid-induced protein 1 OS=Homo sapiens OX=9606 GN=RAI1 PE=1 SV=2" "0.010" "False" "2.303" "1" "2" "2" "2" "1906" "203.2" "8.79" "2.32" "2" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13771" "10743" "ENSG00000108557" "RAI1" "hsa:10743; Q7Z5J4; Q8N3B4; Q8ND08; Q8WU64; Q96JK5; Q9H1C1; Q9H1C2; Q9UF69" "Heme signaling; Circadian Clock" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "3" "0" "0.758" "0.905" "0.597" "0.724" "0.561" "0.754" "1.161" "0.842" "0.408" "68.0" "51.5" "61.5" "40.6" "49.2" "38.1" "51.2" "78.9" "57.3" "27.7" "" "" "" "" "" "" "" "" "" "" "60.3" "42.7" "53.7" "30.3" "41.0" "35.0" "43.3" "65.2" "52.5" "27.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8594684179756660612" "False" "High" "IsMasterProtein" "O77932" "Decapping and exoribonuclease protein OS=Homo sapiens OX=9606 GN=DXO PE=1 SV=2" "0.010" "False" "2.302" "2" "1" "1" "1" "396" "44.9" "7.69" "2.33" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf08652" "1797" "ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765" "DXO" "A2CER3; B0UZ80; hsa:1797; O15004; O77932; O78127; O78128; Q5ST60; Q6IPZ2; Q9NPK4" "" "" "0" "0" "0.926" "0.830" "0.857" "0.793" "1.049" "0.838" "0.800" "0.646" "0.700" "110.7" "102.5" "91.9" "94.8" "87.7" "116.1" "92.7" "88.5" "71.5" "77.5" "" "" "" "" "" "" "" "" "" "" "98.1" "84.9" "80.1" "70.9" "73.2" "106.6" "78.4" "73.2" "65.5" "77.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9223199126957561706" "False" "High" "IsMasterProtein" "P06731" "Carcinoembryonic antigen-related cell adhesion molecule 5 OS=Homo sapiens OX=9606 GN=CEACAM5 PE=1 SV=4" "0.010" "False" "2.293" "1" "1" "1" "1" "702" "76.7" "5.69" "2.74" "1" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07686, Pf13895, Pf13927" "1048" "ENSG00000105388" "CEACAM5" "H9KVA7; hsa:1048; P06731" "Cell surface interactions at the vascular wall; Post-translational modification: synthesis of GPI-anchored proteins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7548754380540719877" "False" "Medium" "IsMasterProtein" "Q96ET8" "Golgi apparatus membrane protein TVP23 homolog C OS=Homo sapiens OX=9606 GN=TVP23C PE=1 SV=3" "0.010" "False" "2.274" "3" "1" "1" "1" "276" "31.1" "9.29" "2.14" "1" "transport" "other membranes" "" "Pf05832" "100533496; 201158" "ENSG00000175106" "TVP23C" "hsa:100533496; hsa:201158; Q3LIC7; Q96ET8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8166757714401601180" "False" "Medium" "IsMasterProtein" "O75964" "ATP synthase subunit g, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MG PE=1 SV=3" "0.011" "False" "2.265" "13" "1" "1" "1" "103" "11.4" "9.64" "3.35" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf04718" "10632" "ENSG00000167283" "ATP5MG" "A8K0K3; hsa:10632; O75964; Q96BV6; Q9UBZ7" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "5" "0" "0.982" "0.994" "1.000" "0.999" "1.104" "1.106" "1.100" "1.196" "0.719" "148.3" "145.6" "147.5" "148.2" "148.2" "163.7" "164.0" "163.2" "177.4" "106.6" "" "" "" "" "" "" "" "" "" "" "131.5" "120.6" "128.7" "110.9" "123.6" "150.4" "138.6" "134.9" "162.7" "106.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2080335372413913728" "False" "Medium" "IsMasterProtein" "O60331" "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma OS=Homo sapiens OX=9606 GN=PIP5K1C PE=1 SV=2" "0.011" "False" "2.262" "1" "1" "1" "1" "668" "73.2" "5.29" "2.24" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "23396" "ENSG00000186111" "PIP5K1C" "B7Z9E7; C6GIJ7; C6GIJ8; hsa:23396; O60331; Q7LE07" "Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" "B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton" "7" "0" "1.057" "1.035" "0.889" "1.175" "1.387" "1.232" "0.947" "1.107" "1.663" "20.7" "21.9" "21.5" "18.4" "24.4" "28.8" "25.5" "19.6" "22.9" "34.5" "" "" "" "" "" "" "" "" "" "" "18.4" "18.2" "18.7" "13.8" "20.3" "26.4" "21.6" "16.2" "21.0" "34.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3567158229513091577" "False" "Medium" "IsMasterProtein" "Q8NDX1" "PH and SEC7 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PSD4 PE=1 SV=2" "0.011" "False" "2.255" "1" "1" "1" "1" "1056" "116.2" "5.48" "2.53" "1" "other biological processes" "plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf01369, Pf15410" "23550" "ENSG00000125637" "PSD4" "A6NEG7; A8K1Y0; hsa:23550; O95621; Q4ZG34; Q6GPH8; Q8IYP4; Q8NDX1" "" "2q13 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629092038123866655" "False" "Medium" "IsMasterProtein" "Q86TP1" "Exopolyphosphatase PRUNE1 OS=Homo sapiens OX=9606 GN=PRUNE1 PE=1 SV=2" "0.011" "False" "2.255" "2" "1" "1" "1" "453" "50.2" "5.50" "2.85" "1" "other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01368, Pf02833" "58497" "ENSG00000143363" "PRUNE1" "B2RCH8; B4DFL7; Q5SZF9; Q659E5; Q6P4E0; Q86TP1; Q8N654; Q96JU5; Q9C071; Q9C072; Q9UIV0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2107690767117566608" "False" "Medium" "IsMasterProtein" "P04150" "Glucocorticoid receptor OS=Homo sapiens OX=9606 GN=NR3C1 PE=1 SV=1" "0.011" "False" "2.249" "1" "1" "1" "1" "777" "85.6" "6.38" "2.64" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf02155" "2908" "ENSG00000113580" "NR3C1" "A0ZXF9; B0LPG8; D3DQF4; F5ATB7; hsa:2908; P04150; P04151; Q53EP5; Q6N0A4" "Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression; Regulation of NPAS4 gene transcription" "Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "515980508248597386" "False" "Medium" "IsMasterProtein" "Q5T1V6" "Probable ATP-dependent RNA helicase DDX59 OS=Homo sapiens OX=9606 GN=DDX59 PE=1 SV=1" "0.011" "False" "2.243" "2" "2" "2" "1" "619" "68.8" "7.44" "4.42" "2" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04438" "83479" "ENSG00000118197" "DDX59" "hsa:83479; Q5T1V6; Q6PJL2; Q8IVW3; Q9H0W3" "" "Ciliopathies" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2300421444410781361" "False" "Medium" "IsMasterProtein" "Q9BRP1" "Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1" "0.011" "False" "2.233" "2" "1" "1" "1" "358" "39.4" "4.86" "2.96" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf04194" "84306" "ENSG00000126249" "PDCD2L" "hsa:84306; Q9BRP1" "" "" "0" "0" "0.766" "0.930" "0.831" "0.649" "0.570" "0.555" "0.494" "0.833" "3.832" "137.1" "105.1" "127.5" "113.9" "89.0" "78.1" "76.1" "67.7" "114.1" "525.3" "" "" "" "" "" "" "" "" "" "" "121.6" "87.0" "111.3" "85.2" "74.2" "71.8" "64.3" "56.0" "104.7" "525.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-739436223450923494" "False" "Medium" "IsMasterProtein" "P28749" "Retinoblastoma-like protein 1 OS=Homo sapiens OX=9606 GN=RBL1 PE=1 SV=3" "0.011" "False" "2.226" "1" "1" "1" "1" "1068" "120.8" "7.50" "2.07" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5933" "ENSG00000080839" "RBL1" "A8K2W5; hsa:5933; P28749; Q4VXA0; Q8N5K6; Q9H1L5; Q9H1M1" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Transcription of E2F targets under negative control by DREAM complex; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; DYRK1A involvement regarding cell proliferation in brain development; ID signaling pathway" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3356255983186646141" "False" "Medium" "IsMasterProtein" "P0C7V7" "Putative signal peptidase complex catalytic subunit SEC11B OS=Homo sapiens OX=9606 GN=SEC11B PE=5 SV=1" "0.011" "False" "2.223" "5" "1" "1" "1" "166" "19.1" "9.66" "2.70" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "" "" "" "SEC11B" "P0C7V7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630467620585670619" "False" "Medium" "IsMasterProtein" "Q9Y6K1" "DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens OX=9606 GN=DNMT3A PE=1 SV=4" "0.011" "False" "2.220" "1" "1" "1" "1" "912" "101.8" "6.57" "2.58" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf00855, Pf17980, Pf21255" "1788" "ENSG00000119772" "DNMT3A" "E9PEB8; hsa:1788; Q86TE8; Q86XF5; Q8IZV0; Q8WXU9; Q9Y6K1" "RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency; Opioid receptor pathways; Spina bifida" "12" "0" "1.065" "0.889" "0.755" "0.692" "0.891" "0.819" "0.877" "0.961" "0.436" "65.0" "69.2" "57.8" "49.1" "45.0" "57.9" "53.3" "57.0" "62.5" "28.4" "" "" "" "" "" "" "" "" "" "" "57.7" "57.4" "50.5" "36.7" "37.5" "53.2" "45.0" "47.1" "57.3" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1944436007343456073" "False" "Medium" "IsMasterProtein" "Q9H7B4" "Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens OX=9606 GN=SMYD3 PE=1 SV=4" "0.011" "False" "2.220" "3" "1" "1" "1" "428" "49.1" "7.25" "2.61" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01753" "64754" "ENSG00000185420" "SMYD3" "A8K0P0; B1AN38; hsa:64754; Q86TL8; Q8N5Z6; Q96AI5; Q9H7B4" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436526655011241506" "False" "Medium" "IsMasterProtein" "P19793" "Retinoic acid receptor RXR-alpha OS=Homo sapiens OX=9606 GN=RXRA PE=1 SV=1" "0.011" "False" "2.204" "2" "1" "2" "1" "462" "50.8" "7.80" "2.90" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf11825" "6256" "ENSG00000186350" "RXRA" "B3KY83; hsa:6256; P19793; Q2NL52; Q2V504" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors; Cytoprotection by HMOX1; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Th17 cell differentiation pathway; Kleefstra syndrome; Vitamin A1 and A5/X pathways; Vitamin A and carotenoid metabolism" "59" "0" "0.892" "0.844" "0.989" "0.628" "1.147" "0.979" "0.972" "0.736" "0.327" "203.5" "181.5" "171.7" "201.2" "127.8" "233.5" "199.3" "197.8" "149.9" "66.5" "" "" "" "" "" "" "" "" "" "" "180.4" "150.3" "149.8" "150.5" "106.6" "214.5" "168.4" "163.5" "137.4" "66.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8759113245393669348" "False" "Medium" "IsMasterProtein" "O75844" "CAAX prenyl protease 1 homolog OS=Homo sapiens OX=9606 GN=ZMPSTE24 PE=1 SV=2" "0.011" "False" "2.196" "2" "1" "1" "1" "475" "54.8" "7.49" "2.44" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01435, Pf16491" "10269" "ENSG00000084073" "ZMPSTE24" "B3KQI7; D3DPU7; hsa:10269; O75844; Q8NDZ8; Q9UBQ2" "" "Adipogenesis; Lamin A processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1864840127282000894" "False" "Medium" "IsMasterProtein" "Q9Y2I1" "Nischarin OS=Homo sapiens OX=9606 GN=NISCH PE=1 SV=3" "0.011" "False" "2.195" "1" "1" "1" "1" "1504" "166.5" "5.14" "2.11" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787" "11188" "ENSG00000010322" "NISCH" "C9J245; hsa:11188; Q6PGP3; Q6PIB4; Q7L8M3; Q7Z2X6; Q9UES6; Q9UEU4; Q9UFW3; Q9Y2I1" "RND2 GTPase cycle; RAC1 GTPase cycle; RND3 GTPase cycle" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043384267201458756" "False" "Medium" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "0.011" "False" "2.189" "3" "1" "1" "1" "421" "47.3" "6.84" "2.65" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton" "5" "0" "0.707" "1.057" "0.837" "0.766" "0.575" "0.886" "0.464" "0.682" "5.371" "23.1" "16.3" "24.4" "19.3" "17.7" "13.3" "20.4" "10.7" "15.7" "123.9" "" "" "" "" "" "" "" "" "" "" "20.5" "13.5" "21.3" "14.5" "14.7" "12.2" "17.3" "8.8" "14.4" "123.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2074616655413557886" "False" "Medium" "IsMasterProtein" "Q9HB20" "Pleckstrin homology domain-containing family A member 3 OS=Homo sapiens OX=9606 GN=PLEKHA3 PE=1 SV=2" "0.012" "False" "2.183" "4" "1" "1" "1" "300" "33.8" "6.65" "2.39" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00169" "65977" "ENSG00000116095" "PLEKHA3" "hsa:65977; Q4ZG69; Q86TQ1; Q9HB20; Q9NXT3" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6214195784572871532" "False" "Medium" "IsMasterProtein" "Q86Y13" "E3 ubiquitin-protein ligase DZIP3 OS=Homo sapiens OX=9606 GN=DZIP3 PE=1 SV=2" "0.012" "False" "2.175" "1" "1" "1" "1" "1208" "138.5" "6.87" "0.00" "1" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13639, Pf18738, Pf19179" "9666" "ENSG00000198919" "DZIP3" "B3KN01; O75162; Q6P3R9; Q6PH82; Q86Y13; Q86Y14; Q86Y15; Q86Y16; Q8IWI0; Q96RS9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769274744551438483" "False" "Medium" "IsMasterProtein" "Q8IXU6" "Solute carrier family 35 member F2 OS=Homo sapiens OX=9606 GN=SLC35F2 PE=1 SV=1" "0.012" "False" "2.154" "3" "1" "1" "1" "374" "41.2" "6.21" "3.27" "1" "transport" "other membranes" "transporter activity" "Pf06027" "54733" "ENSG00000110660" "SLC35F2" "hsa:54733; Q14963; Q5JPA8; Q6ZRQ3; Q8IXU6; Q9H947" "" "" "0" "0" "1.158" "0.756" "1.209" "1.216" "1.186" "1.196" "1.044" "1.022" "0.933" "45.9" "53.1" "34.7" "55.4" "55.8" "54.4" "54.8" "47.9" "46.9" "42.8" "" "" "" "" "" "" "" "" "" "" "40.7" "44.0" "30.2" "41.5" "46.5" "50.0" "46.3" "39.6" "43.0" "42.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7240944493038279722" "False" "Medium" "IsMasterProtein" "Q9Y676" "Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1" "0.012" "False" "2.143" "4" "1" "1" "1" "258" "29.4" "9.38" "2.83" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01084" "28973" "ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813" "MRPS18B" "A6NDQ0; hsa:28973; Q659G4; Q9BS27; Q9Y676" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.727" "0.818" "1.001" "0.698" "0.884" "0.803" "0.617" "0.928" "3.173" "38.4" "27.9" "31.4" "38.5" "26.8" "33.9" "30.8" "23.7" "35.7" "121.9" "" "" "" "" "" "" "" "" "" "" "34.1" "23.1" "27.4" "28.8" "22.4" "31.2" "26.1" "19.6" "32.7" "121.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7187364612041296451" "False" "Medium" "IsMasterProtein" "Q96Q05" "Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2" "0.012" "False" "2.137" "1" "1" "1" "1" "1148" "128.4" "6.62" "2.60" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf08626" "83696" "ENSG00000167632" "TRAPPC9" "hsa:83696; Q4VTT3; Q658K7; Q6P149; Q6ZQT3; Q7L5C4; Q86Y21; Q96Q05; Q96SL2; Q9BQA2" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3107820624180600590" "False" "Medium" "IsMasterProtein" "O75879" "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1" "0.012" "False" "2.127" "1" "1" "1" "1" "557" "61.8" "8.63" "2.65" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf02637, Pf02934" "5188" "ENSG00000059691" "GATB" "hsa:5188; O75879; Q4W5M8; Q53GP4; Q9P0S6; Q9Y2B8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2989305466654419891" "False" "Medium" "IsMasterProtein" "Q6P3S1" "DENN domain-containing protein 1B OS=Homo sapiens OX=9606 GN=DENND1B PE=1 SV=2" "0.012" "False" "2.125" "1" "1" "1" "1" "775" "86.5" "5.83" "2.35" "1" "transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "163486" "ENSG00000213047" "DENND1B" "B5MD89; D3PFD5; hsa:163486; Q5T3B8; Q5T3B9; Q5T3C1; Q5TAI8; Q6B0I8; Q6P3S1; Q8NDT1; Q8TBE6; Q9H774; Q9NXU2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8338375964222400998" "False" "Medium" "IsMasterProtein" "P02760" "Protein AMBP OS=Homo sapiens OX=9606 GN=AMBP PE=1 SV=1" "0.012" "True" "2.122" "2" "1" "1" "1" "352" "39.0" "6.25" "2.61" "1" "cell adhesion;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00014, Pf00061" "259" "ENSG00000106927" "AMBP" "hsa:259; P00977; P02759; P02760; P78491; Q2TU33; Q5TBD7; Q9UC58; Q9UDI8" "Scavenging of heme from plasma" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2677672049916283742" "False" "Medium" "IsMasterProtein" "Q96K30" "RBPJ-interacting and tubulin-associated protein 1 OS=Homo sapiens OX=9606 GN=RITA1 PE=1 SV=1" "0.012" "False" "2.118" "3" "1" "1" "1" "269" "28.6" "11.08" "2.36" "1" "transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf17066" "84934" "ENSG00000139405" "RITA1" "B3KVZ4; C9JIN1; F8VRG5; hsa:84934; Q53GM3; Q96K25; Q96K30" "" "" "0" "0" "1.157" "1.145" "1.343" "0.961" "1.342" "1.227" "0.740" "1.094" "1.002" "32.1" "37.1" "36.8" "43.1" "30.9" "43.1" "39.4" "23.8" "35.1" "32.2" "" "" "" "" "" "" "" "" "" "" "28.5" "30.8" "32.1" "32.3" "25.7" "39.6" "33.3" "19.6" "32.2" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6596351157083836724" "False" "Medium" "IsMasterProtein" "Q8NC56" "LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LEMD2 PE=1 SV=1" "0.012" "False" "2.117" "3" "1" "1" "1" "503" "56.9" "9.00" "1.67" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "" "Pf03020, Pf09402" "221496" "ENSG00000161904" "LEMD2" "B4DVH5; E7EVT2; Q5T972; Q5T974; Q8NC56" "Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "284975731923891311" "False" "Medium" "IsMasterProtein" "Q14644" "Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3" "0.012" "False" "2.114" "1" "1" "1" "1" "834" "95.6" "7.15" "3.38" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "transporter activity;enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "22821" "ENSG00000185989; ENSG00000280477" "RASA3" "A6NL15; F8W6X8; hsa:22821; Q14644; Q8IUY2" "Regulation of RAS by GAPs" "MAPK cascade; Ras signaling; IL-18 signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2213528751694895262" "False" "Medium" "IsMasterProtein" "Q8N2W9" "E3 SUMO-protein ligase PIAS4 OS=Homo sapiens OX=9606 GN=PIAS4 PE=1 SV=1" "0.012" "False" "2.109" "3" "1" "1" "1" "510" "56.5" "6.14" "2.12" "1" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "51588" "ENSG00000105229" "PIAS4" "O75926; Q8N2W9; Q96G19; Q9UN16" "SUMOylation of intracellular receptors; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMOylation of immune response proteins" "Androgen receptor signaling pathway" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5380197694992633096" "False" "Medium" "IsMasterProtein" "Q9BWG4" "Single-stranded DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=SSBP4 PE=1 SV=1" "0.012" "False" "2.109" "3" "1" "2" "1" "385" "39.4" "6.80" "4.50" "1" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04503" "170463" "ENSG00000130511" "SSBP4" "hsa:170463; Q9BWG4; Q9BWW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841037560780449706" "False" "Medium" "IsMasterProtein" "O43663" "Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2" "0.012" "False" "2.103" "2" "1" "1" "1" "620" "71.6" "6.68" "1.86" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03999" "9055" "ENSG00000198901" "PRC1" "A6NC44; B4DLR1; H9KV59; hsa:9055; O43663; Q9BSB6" "RHO GTPases activate CIT" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "537430972224276465" "False" "Medium" "IsMasterProtein" "Q86SX3" "Tubulin epsilon and delta complex protein 1 OS=Homo sapiens OX=9606 GN=TEDC1 PE=1 SV=2" "0.012" "False" "2.101" "2" "1" "1" "1" "495" "54.2" "8.05" "2.45" "1" "other biological processes" "cytoskeleton;other cell component" "" "Pf14970" "283643" "ENSG00000185347" "TEDC1" "B5MDG3; E9PAQ4; hsa:283643; Q86SX3; Q86TT3; Q86TT4; Q86TT5; Q96B41; Q9H7H4" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4465536822655971344" "False" "Medium" "IsMasterProtein" "Q9UPU7" "TBC1 domain family member 2B OS=Homo sapiens OX=9606 GN=TBC1D2B PE=1 SV=2" "0.012" "False" "2.098" "1" "1" "1" "1" "963" "109.8" "6.16" "2.35" "1" "transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00169, Pf00566" "23102" "ENSG00000167202" "TBC1D2B" "A7MD42; hsa:23102; Q8N1F9; Q9NXM0; Q9UPU7" "" "" "0" "0" "0.920" "0.850" "1.082" "0.861" "0.843" "0.918" "0.750" "0.898" "2.821" "148.3" "136.4" "126.1" "160.5" "127.7" "125.0" "136.2" "111.3" "133.2" "418.4" "" "" "" "" "" "" "" "" "" "" "131.5" "113.0" "110.1" "120.1" "106.5" "114.8" "115.1" "92.0" "122.2" "418.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812435587669983300" "False" "Medium" "IsMasterProtein" "Q17RC7" "Exocyst complex component 3-like protein 4 OS=Homo sapiens OX=9606 GN=EXOC3L4 PE=1 SV=2" "0.012" "False" "2.096" "1" "1" "1" "1" "722" "79.8" "6.32" "2.62" "1" "transport;other biological processes" "other cell component" "other molecular function" "Pf06046" "91828" "ENSG00000205436" "EXOC3L4" "hsa:91828; Q14CR2; Q17RC7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4123953138095996018" "False" "Medium" "IsMasterProtein" "O95398" "Rap guanine nucleotide exchange factor 3 OS=Homo sapiens OX=9606 GN=RAPGEF3 PE=1 SV=6" "0.012" "False" "2.094" "1" "1" "1" "1" "923" "103.7" "7.56" "2.77" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf00610, Pf00617, Pf00618" "10411" "ENSG00000079337" "RAPGEF3" "A8K2G5; E7EQC8; hsa:10411; O95398; O95634; Q8WVN0" "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Integrin signaling; Rap1 signalling" "Corticotropin-releasing hormone signaling pathway; EPAC1 and PKA reduction of retinal inflammation" "6" "0" "1.237" "1.331" "1.166" "1.138" "0.575" "1.103" "1.042" "0.776" "0.360" "129.5" "160.2" "172.4" "151.0" "147.4" "74.4" "142.8" "135.0" "100.5" "46.6" "" "" "" "" "" "" "" "" "" "" "114.9" "132.7" "150.5" "112.9" "122.9" "68.4" "120.7" "111.6" "92.2" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1525215200216918096" "False" "Medium" "IsMasterProtein" "Q6UXY8" "Transmembrane channel-like protein 5 OS=Homo sapiens OX=9606 GN=TMC5 PE=1 SV=3" "0.012" "False" "2.089" "1" "1" "1" "1" "1006" "114.7" "8.21" "2.34" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf07810" "79838" "ENSG00000103534" "TMC5" "hsa:79838; Q68DK8; Q6UXY8; Q8IY20; Q8NHV6; Q9H8I7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2935045971182124392" "False" "Medium" "IsMasterProtein" "Q7Z3E5" "LisH domain-containing protein ARMC9 OS=Homo sapiens OX=9606 GN=ARMC9 PE=1 SV=3" "0.012" "False" "2.088" "2" "1" "1" "1" "818" "91.8" "6.20" "1.90" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf21050, Pf21051" "80210" "ENSG00000135931" "ARMC9" "A0A087X1I8; hsa:80210; Q53TI3; Q6P162; Q7L594; Q7Z3E5; Q86WG2; Q96JF9; Q9H9R8" "" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-357583033537535039" "False" "Medium" "IsMasterProtein" "Q9NX20" "Large ribosomal subunit protein uL16m OS=Homo sapiens OX=9606 GN=MRPL16 PE=1 SV=1" "0.013" "False" "2.075" "3" "1" "1" "1" "251" "28.4" "10.13" "2.65" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00252" "54948" "ENSG00000166902" "MRPL16" "hsa:54948; Q9BYD0; Q9HB70; Q9NX20" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4735904607346551570" "False" "Medium" "IsMasterProtein" "P0C0L4" "Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2" "0.013" "False" "2.074" "0" "1" "1" "1" "1744" "192.7" "7.08" "2.01" "1" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791, Pf21145" "720; 721" "ENSG00000206340; ENSG00000227746; ENSG00000244731" "C4A" "A6H8M8; A6NHJ5; A7E2V2; B0QZR6; B0V2C8; B2RUT6; B7ZVZ6; hsa:720; hsa:721; P01028; P0C0L4; P78445; Q13160; Q13906; Q14033; Q14835; Q4LE82; Q5JNX2; Q5JQM8; Q6P4R1; Q6U2E5; Q6U2E8; Q6U2F0; Q6U2F3; Q6U2F4; Q6U2F6; Q6U2F8; Q6U2G0; Q96EG2; Q96SA8; Q9NPK5; Q9UIP5" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5" "Allograft rejection; Complement system; Dengue-2 interactions with complement and coagulation cascades; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157641750499335080" "False" "Medium" "IsMasterProtein" "Q9C0C7" "Activating molecule in BECN1-regulated autophagy protein 1 OS=Homo sapiens OX=9606 GN=AMBRA1 PE=1 SV=2" "0.013" "False" "2.074" "1" "1" "1" "1" "1298" "142.4" "7.18" "2.28" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "55626" "ENSG00000110497" "AMBRA1" "A6XN33; D3DQP8; G3V193; hsa:55626; Q86XD6; Q9C0C7; Q9H8Z0; Q9NXE7" "Macroautophagy" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1341245629562408069" "False" "Medium" "IsMasterProtein" "A6NFU8" "Pyroglutamyl-peptidase 1-like protein OS=Homo sapiens OX=9606 GN=PGPEP1L PE=2 SV=4" "0.012" "False" "2.070" "4" "1" "1" "1" "196" "21.6" "8.09" "3.29" "1" "protein metabolism" "" "other molecular function" "Pf01470" "145814" "ENSG00000183571" "PGPEP1L" "A6NFU8; H0YF86; hsa:145814" "" "" "0" "0" "0.950" "0.925" "1.125" "0.842" "1.023" "0.972" "0.958" "0.836" "0.845" "211.1" "200.5" "195.2" "237.4" "177.7" "216.0" "205.1" "202.3" "176.5" "178.4" "" "" "" "" "" "" "" "" "" "" "187.2" "166.1" "170.3" "177.5" "148.1" "198.4" "173.3" "167.2" "161.9" "178.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3055099900900343627" "False" "Medium" "IsMasterProtein" "Q9P0M9" "Large ribosomal subunit protein bL27m OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1" "0.012" "False" "2.069" "5" "1" "1" "1" "148" "16.1" "10.42" "2.65" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01016" "51264" "ENSG00000108826" "MRPL27" "B2RE14; hsa:51264; Q9P0M9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699158399968223668" "False" "Medium" "IsMasterProtein" "Q15311" "RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3" "0.013" "False" "2.062" "1" "1" "1" "1" "655" "76.0" "5.88" "3.11" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00620, Pf20924" "10928" "ENSG00000017797" "RALBP1" "D3DUI0; hsa:10928; Q15311" "CDC42 GTPase cycle; RAC1 GTPase cycle" "RalA downstream regulated genes; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6803060503545767459" "False" "Medium" "IsMasterProtein" "Q8NDX6" "Zinc finger protein 740 OS=Homo sapiens OX=9606 GN=ZNF740 PE=1 SV=1" "0.013" "False" "2.055" "4" "1" "1" "1" "193" "21.8" "9.19" "3.22" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "283337" "ENSG00000139651" "ZNF740" "A8K9M9; hsa:283337; Q8NDX6" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1039614738747388344" "False" "Medium" "IsMasterProtein" "Q5BJF2" "Sigma intracellular receptor 2 OS=Homo sapiens OX=9606 GN=TMEM97 PE=1 SV=1" "0.013" "False" "2.054" "6" "1" "2" "1" "176" "20.8" "9.38" "2.66" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf05241" "27346" "ENSG00000109084" "TMEM97" "B4DS02; hsa:27346; Q07823; Q5BJF2" "" "" "0" "0" "0.974" "0.913" "1.029" "1.061" "1.065" "0.974" "0.872" "1.091" "0.725" "48.9" "47.6" "44.7" "50.3" "51.9" "52.1" "47.6" "42.7" "53.3" "35.4" "" "" "" "" "" "" "" "" "" "" "43.4" "39.5" "39.0" "37.6" "43.3" "47.9" "40.3" "35.3" "48.9" "35.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819084498940790760" "False" "Medium" "IsMasterProtein" "Q6ZVM7" "TOM1-like protein 2 OS=Homo sapiens OX=9606 GN=TOM1L2 PE=1 SV=1" "0.013" "False" "2.049" "2" "1" "1" "1" "507" "55.5" "4.79" "2.50" "1" "transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00790, Pf03127" "146691" "ENSG00000175662" "TOM1L2" "B7Z2L7; B7Z7F4; hsa:146691; Q6ZVM7; Q86V61; Q8TDE7; Q96M88" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "0.909" "0.854" "0.935" "0.914" "0.737" "0.875" "0.760" "0.859" "1.528" "111.0" "100.8" "94.7" "103.8" "101.5" "81.8" "97.1" "84.3" "95.3" "169.6" "" "" "" "" "" "" "" "" "" "" "98.4" "83.5" "82.7" "77.6" "84.6" "75.1" "82.1" "69.7" "87.4" "169.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7567103960318727217" "False" "Medium" "IsMasterProtein" "Q08999" "Retinoblastoma-like protein 2 OS=Homo sapiens OX=9606 GN=RBL2 PE=1 SV=3" "0.013" "False" "2.049" "1" "1" "1" "1" "1139" "128.3" "7.44" "2.11" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf11934" "5934" "ENSG00000103479" "RBL2" "B7Z913; hsa:5934; Q08999; Q15073; Q16084; Q8NE70; Q92812" "G1/S-Specific Transcription; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; FOXO-mediated transcription of cell cycle genes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcription of E2F targets under negative control by DREAM complex; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Adipogenesis; TGF-beta signaling pathway; PI3K-Akt signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; ID signaling pathway; DNA damage response (only ATM dependent); Monoamine transport" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2675022864757933471" "False" "Medium" "IsMasterProtein" "P98161" "Polycystin-1 OS=Homo sapiens OX=9606 GN=PKD1 PE=1 SV=3" "0.013" "False" "2.046" "0" "1" "1" "1" "4303" "462.2" "6.73" "2.57" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00059, Pf00801, Pf01477, Pf01822, Pf02010, Pf08016, Pf13855, Pf20519" "5310" "ENSG00000008710" "PKD1" "P98161; Q15140; Q15141" "VxPx cargo-targeting to cilium" "Polycystic kidney disease pathway; Interactions between LOXL4 and oxidative stress pathway; GPR40 pathway; Epithelial to mesenchymal transition in colorectal cancer; Ciliopathies; Bardet-Biedl syndrome" "7" "0" "1.148" "1.117" "1.188" "1.141" "1.051" "1.684" "1.461" "1.297" "2.081" "95.4" "109.5" "106.6" "113.3" "108.8" "100.2" "160.6" "139.3" "123.8" "198.5" "" "" "" "" "" "" "" "" "" "" "84.6" "90.7" "93.0" "84.7" "90.7" "92.1" "135.8" "115.1" "113.5" "198.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2890344552958539961" "False" "Medium" "IsMasterProtein" "O75569" "Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1" "0.013" "False" "2.045" "3" "1" "1" "1" "313" "34.4" "8.41" "2.87" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035" "8575" "ENSG00000180228" "PRKRA" "A8K3I6; hsa:8575; O75569; Q53G24; Q6X7T5; Q8NDK4" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "VEGFA-VEGFR2 signaling; Ebola virus infection in host" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8337602067628073965" "False" "Medium" "IsMasterProtein" "O00159" "Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4" "0.013" "False" "2.045" "1" "1" "1" "1" "1063" "121.6" "9.41" "2.63" "1" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4641" "ENSG00000197879" "MYO1C" "hsa:4641; O00159; Q4LE56; Q6NVJ7; Q86Y95" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane" "VEGFA-VEGFR2 signaling; Insulin signaling; 10q11.21q11.23 copy number variation syndrome" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7929132600900675326" "False" "Medium" "IsMasterProtein" "Q53GL7" "Protein mono-ADP-ribosyltransferase PARP10 OS=Homo sapiens OX=9606 GN=PARP10 PE=1 SV=2" "0.013" "False" "2.042" "1" "1" "1" "1" "1025" "109.9" "4.97" "2.30" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00644" "84875" "ENSG00000178685" "PARP10" "hsa:84875; Q53GL7; Q8N2I0; Q8WV05; Q96CH7; Q96K72" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382740321350681775" "False" "Medium" "IsMasterProtein" "Q9HCM3" "UPF0606 protein KIAA1549 OS=Homo sapiens OX=9606 GN=KIAA1549 PE=1 SV=4" "0.013" "False" "2.032" "1" "1" "1" "1" "1950" "210.6" "6.11" "0.00" "1" "" "plasma membrane;other membranes;other cell component" "" "Pf12877" "57670" "ENSG00000122778" "KIAA1549" "B6HY55; B6HY56; B6HY58; B6HY60; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66; hsa:57670; Q5BJD6; Q8IY15; Q9H0M3; Q9HCM3" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5196394549713774835" "False" "Medium" "IsMasterProtein" "Q69YU5" "Ubiquinol-cytochrome c reductase complex assembly factor 6 OS=Homo sapiens OX=9606 GN=UQCC6 PE=1 SV=2" "0.013" "False" "2.030" "10" "1" "1" "1" "71" "8.0" "9.16" "2.91" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14990" "728568" "ENSG00000204954" "UQCC6" "hsa:728568; Q69YU5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4669582213055541224" "False" "Medium" "IsMasterProtein" "P13686" "Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=3" "0.013" "False" "2.026" "2" "1" "1" "1" "325" "36.6" "8.70" "3.59" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf00149" "54" "ENSG00000102575" "ACP5" "A8K3V2; hsa:54; P13686; Q2TAB1; Q6IAS6; Q9UCJ5; Q9UCJ6; Q9UCJ7" "Vitamin B2 (riboflavin) metabolism" "Osteoclast signaling; RANKL/RANK signaling pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021851569600186030" "False" "Medium" "IsMasterProtein" "A2A288" "Probable ribonuclease ZC3H12D OS=Homo sapiens OX=9606 GN=ZC3H12D PE=1 SV=3" "0.013" "False" "2.023" "2" "1" "1" "1" "527" "58.0" "8.68" "2.21" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11977, Pf18039" "340152" "ENSG00000178199" "ZC3H12D" "A1L178; A2A288; B2RXF4; B7WNU7; B9ZZP9; B9ZZQ0; hsa:340152; Q6ZRW2" "" "" "0" "0" "0.915" "0.941" "1.810" "1.376" "0.824" "1.306" "1.198" "1.035" "2.119" "126.0" "115.3" "118.6" "228.1" "173.3" "103.9" "164.6" "151.0" "130.4" "267.0" "" "" "" "" "" "" "" "" "" "" "111.7" "95.5" "103.5" "170.6" "144.5" "95.4" "139.1" "124.8" "119.6" "267.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "Medium" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.013" "False" "2.020" "3" "1" "1" "1" "248" "27.6" "5.30" "3.15" "1" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "0.948" "0.835" "1.030" "1.052" "1.092" "1.044" "1.033" "0.970" "0.614" "125.5" "118.9" "104.7" "129.3" "132.0" "137.0" "131.1" "129.6" "121.7" "77.0" "" "" "" "" "" "" "" "" "" "" "111.3" "98.5" "91.4" "96.7" "110.0" "125.9" "110.8" "107.1" "111.6" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8271542521026884371" "False" "Medium" "IsMasterProtein" "Q9NQC8" "Intraflagellar transport protein 46 homolog OS=Homo sapiens OX=9606 GN=IFT46 PE=1 SV=1" "0.013" "False" "2.019" "3" "1" "1" "1" "304" "34.3" "4.54" "2.34" "1" "cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "" "Pf12317" "56912" "ENSG00000118096" "IFT46" "A8K0F6; hsa:56912; Q9H6V5; Q9NQC8" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR)" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "Medium" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.013" "False" "2.018" "2" "1" "1" "1" "396" "44.2" "5.19" "3.33" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "Processing of Capped Intron-Containing Pre-mRNA" "" "1" "0" "1.015" "1.004" "0.933" "0.903" "1.049" "1.037" "0.906" "1.006" "3.004" "133.8" "135.8" "134.4" "124.9" "120.9" "140.5" "138.7" "121.3" "134.6" "402.1" "" "" "" "" "" "" "" "" "" "" "118.7" "112.5" "117.3" "93.4" "100.8" "129.0" "117.3" "100.3" "123.5" "402.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3088066192462104792" "False" "Medium" "IsMasterProtein" "O15534" "Period circadian protein homolog 1 OS=Homo sapiens OX=9606 GN=PER1 PE=1 SV=2" "0.013" "False" "2.014" "1" "1" "1" "1" "1290" "136.1" "6.09" "2.71" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08447, Pf12114, Pf21353" "5187" "ENSG00000179094" "PER1" "B2RPA8; B4DI49; D3DTR3; hsa:5187; O15534" "Circadian Clock" "Melatonin metabolism and effects; Exercise-induced circadian regulation; Th17 cell differentiation pathway; Clock-controlled autophagy in bone metabolism; NF1 copy number variation syndrome ; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "7" "0" "0.804" "0.839" "0.766" "0.912" "0.835" "0.808" "0.749" "0.845" "2.172" "55.2" "44.4" "46.4" "42.3" "50.4" "46.1" "44.6" "41.4" "46.7" "120.0" "" "" "" "" "" "" "" "" "" "" "49.0" "36.8" "40.5" "31.6" "42.0" "42.4" "37.7" "34.2" "42.8" "120.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4670744058278942272" "False" "Medium" "IsMasterProtein" "Q9UN74" "Protocadherin alpha-4 OS=Homo sapiens OX=9606 GN=PCDHA4 PE=1 SV=1" "0.013" "False" "2.013" "1" "1" "2" "1" "947" "102.2" "5.08" "4.58" "1" "cell adhesion;developmental processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974" "56144" "ENSG00000204967; ENSG00000291652" "PCDHA4" "hsa:56144; O75285; Q2M253; Q9UN74" "" "GDNF signaling" "1" "0" "1.113" "0.916" "1.059" "1.077" "1.063" "1.187" "1.135" "0.988" "0.298" "206.8" "230.3" "189.4" "219.1" "222.6" "219.9" "245.4" "234.7" "204.4" "61.5" "" "" "" "" "" "" "" "" "" "" "183.4" "190.8" "165.2" "163.9" "185.7" "202.0" "207.4" "194.0" "187.4" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343955122227256194" "False" "Medium" "IsMasterProtein" "Q01831" "DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4" "0.013" "False" "2.009" "1" "1" "1" "1" "940" "105.9" "8.90" "1.76" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03835, Pf10403, Pf10404, Pf10405" "7508" "ENSG00000154767" "XPC" "B4DIP3; E9PB96; E9PH69; hsa:7508; Q01831; Q53GT7; Q96AX0" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "0.895" "0.761" "0.725" "0.577" "0.479" "0.649" "0.891" "1.157" "0.531" "421.3" "377.0" "320.4" "305.3" "243.1" "201.8" "273.3" "375.4" "487.5" "223.9" "" "" "" "" "" "" "" "" "" "" "373.6" "312.3" "279.6" "228.3" "202.7" "185.4" "230.9" "310.3" "447.1" "223.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5678311735532383870" "False" "Medium" "IsMasterProtein" "Q9NY28" "Probable polypeptide N-acetylgalactosaminyltransferase 8 OS=Homo sapiens OX=9606 GN=GALNT8 PE=1 SV=1" "0.013" "False" "2.008" "1" "1" "1" "1" "637" "72.8" "8.87" "3.15" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00535, Pf00652" "26290" "ENSG00000130035" "GALNT8" "B2RU02; hsa:26290; Q9NY28" "O-linked glycosylation of mucins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139945587606400296" "False" "Medium" "IsMasterProtein" "Q07352" "mRNA decay activator protein ZFP36L1 OS=Homo sapiens OX=9606 GN=ZFP36L1 PE=1 SV=1" "0.013" "False" "2.005" "2" "1" "1" "1" "338" "36.3" "7.96" "3.48" "1" "cell adhesion;cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "677" "ENSG00000185650" "ZFP36L1" "hsa:677; Q07352; Q13851" "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "Modulators of TCR signaling and T cell activation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564973388906415615" "False" "Medium" "IsMasterProtein" "Q96DY7" "Mdm2-binding protein OS=Homo sapiens OX=9606 GN=MTBP PE=1 SV=1" "0.013" "False" "2.005" "1" "1" "3" "1" "904" "102.1" "7.77" "8.80" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf14918, Pf14919, Pf14920" "27085" "ENSG00000172167" "MTBP" "B4DUR5; hsa:27085; Q96DY7; Q9HA89" "" "" "0" "0" "1.040" "0.987" "1.028" "1.046" "0.980" "1.034" "1.058" "0.901" "0.503" "953.8" "992.2" "941.7" "980.6" "997.6" "934.9" "986.6" "1009.3" "859.5" "479.7" "" "" "" "" "" "" "" "" "" "" "845.8" "821.9" "821.7" "733.4" "831.8" "858.8" "833.9" "834.2" "788.3" "479.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337623474681162042" "False" "Medium" "IsMasterProtein" "P18074" "General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1" "0.013" "False" "2.003" "1" "1" "1" "1" "760" "86.9" "7.15" "2.47" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf06777, Pf13307" "2068" "ENSG00000104884" "ERCC2" "hsa:2068; P18074; Q2TB78; Q2YDY2; Q7KZU6; Q8N721" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Cytosolic iron-sulfur cluster assembly; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Fluoropyrimidine activity; Eukaryotic transcription initiation; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-775611795353196892" "False" "Medium" "IsMasterProtein" "Q86XI2" "Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1" "0.014" "False" "1.996" "1" "1" "2" "1" "1143" "130.9" "6.87" "2.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12422" "54892" "ENSG00000146918" "NCAPG2" "A4D228; hsa:54892; Q7Z3J9; Q86XI2; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6" "Condensation of Prophase Chromosomes" "Mesodermal commitment pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198749992449269920" "False" "Medium" "IsMasterProtein" "Q5THR3" "EF-hand calcium-binding domain-containing protein 6 OS=Homo sapiens OX=9606 GN=EFCAB6 PE=1 SV=1" "0.014" "False" "1.994" "1" "1" "1" "1" "1501" "172.8" "8.40" "3.91" "1" "" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08976, Pf13499, Pf13833" "64800" "ENSG00000186976" "EFCAB6" "A8K8P6; A8K8Y3; B0QYI4; B0QYI6; hsa:64800; Q5THR3; Q5U5T6; Q9BY88; Q9H5C4; Q9NSF5" "" "Androgen receptor signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6486637706643668216" "False" "Medium" "IsMasterProtein" "Q8TBE0" "Bromo adjacent homology domain-containing 1 protein OS=Homo sapiens OX=9606 GN=BAHD1 PE=1 SV=2" "0.014" "False" "1.991" "1" "1" "1" "1" "780" "84.6" "9.07" "2.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01426" "22893" "ENSG00000140320" "BAHD1" "hsa:22893; Q8NDF7; Q8TBE0; Q9Y2F4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6600262184831849925" "False" "Medium" "IsMasterProtein" "Q9P086" "Mediator of RNA polymerase II transcription subunit 11 OS=Homo sapiens OX=9606 GN=MED11 PE=1 SV=2" "0.015" "False" "1.985" "6" "1" "1" "1" "117" "13.1" "5.96" "1.75" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10280" "400569" "ENSG00000161920" "MED11" "hsa:400569; Q6NS89; Q9P086" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-203379576220599078" "False" "Medium" "IsMasterProtein" "Q13158" "FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1" "0.015" "False" "1.980" "3" "1" "1" "1" "208" "23.3" "5.69" "2.75" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf01335" "8772" "ENSG00000168040" "FADD" "hsa:8772; Q13158; Q14866; Q6IBR4" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway" "33" "0" "0.879" "1.059" "1.265" "0.953" "0.924" "1.036" "0.897" "0.972" "3.716" "38.6" "33.9" "40.9" "48.8" "36.8" "35.7" "40.0" "34.6" "37.5" "143.4" "" "" "" "" "" "" "" "" "" "" "34.2" "28.1" "35.7" "36.5" "30.7" "32.8" "33.8" "28.6" "34.4" "143.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6085773756900444250" "False" "Medium" "IsMasterProtein" "P01706" "Immunoglobulin lambda variable 2-11 OS=Homo sapiens OX=9606 GN=IGLV2-11 PE=1 SV=2" "0.015" "False" "1.979" "7" "1" "1" "1" "119" "12.6" "7.24" "3.44" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07686" "" "ENSG00000211668" "IGLV2-11" "A0A075B6K3; P01706; P01707; P01708; P01712; P01713; P80422" "Potential therapeutics for SARS; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564397710513388870" "False" "Medium" "IsMasterProtein" "Q9NW81" "Distal membrane-arm assembly complex protein 2 OS=Homo sapiens OX=9606 GN=DMAC2 PE=1 SV=3" "0.015" "False" "1.979" "3" "1" "1" "1" "257" "29.2" "6.43" "2.88" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "" "" "55101" "ENSG00000105341" "DMAC2" "B4DDC0; B4DMZ4; B4DP55; B4DXE8; F5H4W7; hsa:55101; K7EMF6; Q96D43; Q9NW81" "" "" "0" "0" "1.019" "1.250" "1.312" "1.225" "1.499" "1.579" "1.318" "1.324" "1.132" "48.1" "49.0" "60.1" "63.0" "58.9" "72.0" "75.9" "63.3" "63.6" "54.4" "" "" "" "" "" "" "" "" "" "" "42.6" "40.6" "52.4" "47.1" "49.1" "66.1" "64.1" "52.3" "58.3" "54.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9004542046363499046" "False" "Medium" "IsMasterProtein" "Q8WVK2" "U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP27 PE=1 SV=1" "0.015" "False" "1.978" "6" "1" "1" "1" "155" "18.8" "11.62" "2.93" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf08648" "11017" "ENSG00000124380" "SNRNP27" "hsa:11017; Q15410; Q8WVK2" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729715390421816171" "False" "Medium" "IsMasterProtein" "Q6PK18" "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=OGFOD3 PE=1 SV=2" "0.015" "False" "1.978" "3" "1" "1" "1" "319" "35.6" "8.18" "3.43" "1" "" "" "other molecular function" "Pf13640" "79701" "ENSG00000181396" "OGFOD3" "C9JDC8; hsa:79701; Q6PK18; Q8IZ37; Q9H6J2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5463770494626313283" "False" "Medium" "IsMasterProtein" "Q9C035" "Tripartite motif-containing protein 5 OS=Homo sapiens OX=9606 GN=TRIM5 PE=1 SV=1" "0.015" "False" "1.976" "2" "1" "1" "1" "493" "56.3" "6.05" "2.13" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "85363" "ENSG00000132256" "TRIM5" "A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1; hsa:85363; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; Q2MLW6; Q2MLW7; Q2MLX1; Q2MLX2; Q2MLX3; Q2MLX5; Q2MLY3; Q2MLY4; Q2V6Q6; Q6GX26; Q8WU46; Q96SR5; Q9C031; Q9C032; Q9C033; Q9C034; Q9C035" "Interferon gamma signaling" "Mesodermal commitment pathway" "2" "0" "1.178" "0.990" "1.170" "1.130" "1.053" "1.017" "0.417" "1.020" "6.265" "25.7" "30.2" "25.4" "30.0" "29.0" "27.0" "26.1" "10.7" "26.2" "160.9" "" "" "" "" "" "" "" "" "" "" "22.8" "25.0" "22.2" "22.5" "24.2" "24.8" "22.1" "8.9" "24.0" "160.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544281291997683624" "False" "Medium" "IsMasterProtein" "Q13515" "Phakinin OS=Homo sapiens OX=9606 GN=BFSP2 PE=1 SV=1" "0.016" "False" "1.964" "2" "1" "1" "1" "415" "45.9" "5.55" "1.92" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "8419" "ENSG00000170819" "BFSP2" "hsa:8419; Q13515; Q14D32; Q9HBW5" "" "" "0" "0" "0.947" "0.813" "0.682" "0.705" "0.866" "0.700" "0.867" "0.877" "1.015" "13.7" "13.0" "11.1" "9.3" "9.7" "11.9" "9.6" "11.9" "12.0" "13.9" "" "" "" "" "" "" "" "" "" "" "12.1" "10.7" "9.7" "7.0" "8.1" "10.9" "8.1" "9.8" "11.0" "13.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327119475881107190" "False" "Medium" "IsMasterProtein" "Q2M2I3" "Protein FAM83E OS=Homo sapiens OX=9606 GN=FAM83E PE=1 SV=2" "0.016" "False" "1.959" "3" "1" "1" "1" "478" "51.7" "9.35" "2.00" "1" "signal transduction" "" "other molecular function" "Pf07894" "54854" "ENSG00000105523" "FAM83E" "hsa:54854; Q2M2I3; Q9NXK1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-796628633734857382" "False" "Medium" "IsMasterProtein" "Q13439" "Golgin subfamily A member 4 OS=Homo sapiens OX=9606 GN=GOLGA4 PE=1 SV=1" "0.016" "False" "1.957" "0" "1" "1" "1" "2230" "261.0" "5.39" "2.80" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01465" "2803" "ENSG00000144674" "GOLGA4" "F8W8Q7; hsa:2803; Q13270; Q13439; Q13654; Q14436; Q59EW8" "Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631621731617011436" "False" "Medium" "IsMasterProtein" "Q12955" "Ankyrin-3 OS=Homo sapiens OX=9606 GN=ANK3 PE=1 SV=3" "0.016" "False" "1.955" "0" "1" "1" "1" "4377" "480.1" "6.49" "2.15" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00531, Pf00791, Pf12796, Pf17809" "288" "ENSG00000151150" "ANK3" "B1AQT2; B4DIL1; E9PE32; hsa:288; Q12955; Q13484; Q5CZH9; Q5VXD5; Q7Z3G4; Q9H0P5" "COPI-mediated anterograde transport; Interaction between L1 and Ankyrins" "Splicing factor NOVA regulated synaptic proteins" "3" "0" "1.977" "1.288" "1.543" "1.696" "2.035" "1.288" "1.263" "1.669" "2.506" "10.9" "21.6" "14.0" "16.8" "18.5" "22.2" "14.0" "13.8" "18.2" "27.3" "" "" "" "" "" "" "" "" "" "" "9.7" "17.9" "12.3" "12.6" "15.4" "20.4" "11.9" "11.4" "16.7" "27.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7840164925213101578" "False" "Medium" "IsMasterProtein" "Q9NVW2" "E3 ubiquitin-protein ligase RLIM OS=Homo sapiens OX=9606 GN=RLIM PE=1 SV=3" "0.016" "False" "1.955" "2" "1" "1" "1" "624" "68.5" "7.56" "1.73" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13639" "51132" "ENSG00000131263" "RLIM" "B2RBQ1; D3DTE0; hsa:51132; Q96D38; Q9NVW2; Q9Y598" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2903572193921155730" "False" "Medium" "IsMasterProtein" "Q8NBK3" "Formylglycine-generating enzyme OS=Homo sapiens OX=9606 GN=SUMF1 PE=1 SV=3" "0.016" "False" "1.954" "3" "1" "1" "1" "374" "40.5" "6.65" "3.96" "1" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf03781" "285362" "ENSG00000144455" "SUMF1" "B4DXK5; B7XD05; E9PGL0; G5E9B0; hsa:285362; Q0VAC6; Q0VAC7; Q2NL78; Q53ZE4; Q6UY39; Q8NBK3; Q96AK5; Q96DK8" "Glycosphingolipid catabolism; The activation of arylsulfatases" "" "2" "0" "1.008" "1.004" "1.152" "0.987" "1.024" "1.092" "0.992" "1.020" "0.704" "127.1" "128.1" "127.6" "146.3" "125.5" "130.1" "138.8" "126.1" "129.6" "89.5" "" "" "" "" "" "" "" "" "" "" "112.7" "106.1" "111.3" "109.4" "104.6" "119.5" "117.3" "104.2" "118.9" "89.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1639956808395934598" "False" "Medium" "IsMasterProtein" "Q9UKT4" "F-box only protein 5 OS=Homo sapiens OX=9606 GN=FBXO5 PE=1 SV=1" "0.016" "False" "1.952" "2" "1" "1" "1" "447" "50.1" "8.92" "2.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00646" "26271" "ENSG00000112029" "FBXO5" "B3KNX5; hsa:26271; Q5TF47; Q8WV29; Q9UGC8; Q9UKT4" "SCF-beta-TrCP mediated degradation of Emi1; G1/S-Specific Transcription; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558457419742153856" "False" "Medium" "IsMasterProtein" "P53567" "CCAAT/enhancer-binding protein gamma OS=Homo sapiens OX=9606 GN=CEBPG PE=1 SV=1" "0.016" "False" "1.948" "5" "1" "2" "1" "150" "16.4" "9.77" "5.46" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1054" "ENSG00000153879" "CEBPG" "B2R946; hsa:1054; P53567; Q5U052" "Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Differentiation of white and brown adipocyte; Transcriptional cascade regulating adipogenesis" "5" "0" "0.827" "0.761" "0.881" "0.841" "0.802" "0.984" "0.918" "0.883" "0.424" "259.4" "214.4" "197.3" "228.6" "218.2" "207.9" "255.2" "238.0" "229.0" "109.9" "" "" "" "" "" "" "" "" "" "" "230.0" "177.6" "172.2" "170.9" "181.9" "191.0" "215.7" "196.8" "210.0" "109.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740560991068464238" "False" "Medium" "IsMasterProtein" "Q93084" "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 OS=Homo sapiens OX=9606 GN=ATP2A3 PE=1 SV=3" "0.017" "False" "1.944" "1" "1" "1" "1" "999" "109.2" "5.52" "2.95" "1" "stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf00702, Pf13246" "489" "ENSG00000074370" "ATP2A3" "A8MZG0; D3DTJ8; hsa:489; O60900; O60901; O75501; O75502; Q16115; Q6JHX1; Q8TEX5; Q8TEX6; Q93084" "Ion homeostasis; Ion transport by P-type ATPases; Pre-NOTCH Processing in Golgi; Reduction of cytosolic Ca++ levels" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Alzheimer's disease; Calcium regulation in cardiac cells" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7032664497322954612" "False" "Medium" "IsMasterProtein" "Q7LC44" "Activity-regulated cytoskeleton-associated protein OS=Homo sapiens OX=9606 GN=ARC PE=1 SV=1" "0.017" "False" "1.939" "2" "1" "1" "1" "396" "45.3" "5.63" "2.77" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf18162, Pf19284, Pf21395" "23237" "ENSG00000198576" "ARC" "hsa:23237; Q7LC44; Q9UJW6; Q9Y469" "NGF-stimulated transcription" "BDNF-TrkB signaling; Serotonin and anxiety-related events; Serotonin and anxiety; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Opioid receptor pathways; Orexin receptor pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "813954222595635444" "False" "Medium" "IsMasterProtein" "Q9H668" "CST complex subunit STN1 OS=Homo sapiens OX=9606 GN=STN1 PE=1 SV=2" "0.017" "False" "1.939" "3" "1" "1" "1" "368" "42.1" "6.07" "2.72" "1" "cell organization and biogenesis;DNA metabolism;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf01336, Pf09170" "79991" "ENSG00000107960" "STN1" "D3DR99; hsa:79991; Q5TCZ0; Q9H668" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation" "Lung fibrosis" "3" "0" "1.005" "0.808" "1.113" "0.724" "0.854" "1.037" "0.986" "0.913" "0.380" "132.5" "133.2" "107.1" "147.5" "95.9" "113.1" "137.4" "130.6" "120.9" "50.3" "" "" "" "" "" "" "" "" "" "" "117.5" "110.3" "93.4" "110.3" "80.0" "103.9" "116.1" "108.0" "110.9" "50.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2973067130680556311" "False" "Medium" "IsMasterProtein" "Q6ZVF9" "G protein-regulated inducer of neurite outgrowth 3 OS=Homo sapiens OX=9606 GN=GPRIN3 PE=1 SV=2" "0.017" "False" "1.936" "1" "1" "1" "1" "776" "82.4" "7.56" "2.75" "1" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes" "" "Pf15235" "285513" "ENSG00000185477" "GPRIN3" "hsa:285513; Q6ZVF9; Q8IVE4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6309922983618933314" "False" "Medium" "IsMasterProtein" "Q96JK9" "Mastermind-like protein 3 OS=Homo sapiens OX=9606 GN=MAML3 PE=1 SV=4" "0.017" "False" "1.934" "1" "1" "1" "1" "1138" "122.2" "7.52" "2.50" "1" "signal transduction;other biological processes" "nucleus" "other molecular function" "Pf09596, Pf20801, Pf20802" "55534" "ENSG00000196782" "MAML3" "B2RNU9; B3KVV7; E7EVW8; hsa:55534; Q96JK9" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Formation of paraxial mesoderm; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Notch signaling; Pathways affected in adenoid cystic carcinoma; Canonical and non-canonical Notch signaling; Notch signaling pathway" "15" "0" "0.806" "0.780" "0.920" "0.691" "1.089" "0.663" "0.628" "0.932" "0.488" "28.0" "22.6" "21.8" "25.8" "19.4" "30.5" "18.6" "17.6" "26.1" "13.7" "" "" "" "" "" "" "" "" "" "" "24.8" "18.7" "19.1" "19.3" "16.1" "28.0" "15.7" "14.5" "24.0" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2068403974864903156" "False" "Medium" "IsMasterProtein" "Q13530" "Serine incorporator 3 OS=Homo sapiens OX=9606 GN=SERINC3 PE=1 SV=2" "0.017" "False" "1.930" "1" "1" "1" "1" "473" "52.5" "7.46" "3.00" "1" "other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity" "Pf03348" "10955" "ENSG00000132824" "SERINC3" "B4DUE9; hsa:10955; O43717; Q13530; Q9BR33" "Serine biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3705334322242747100" "False" "Medium" "IsMasterProtein" "Q12788" "Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2" "0.017" "False" "1.929" "1" "1" "1" "1" "808" "89.0" "6.90" "2.71" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf08625" "10607" "ENSG00000183751; ENSG00000291938" "TBL3" "hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8414928618058390258" "False" "Medium" "IsMasterProtein" "Q8N9N2" "Activating signal cointegrator 1 complex subunit 1 OS=Homo sapiens OX=9606 GN=ASCC1 PE=1 SV=1" "0.017" "False" "1.927" "2" "1" "1" "1" "400" "45.5" "5.54" "2.87" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf10469" "51008" "ENSG00000138303" "ASCC1" "hsa:51008; Q5SW06; Q5SW07; Q8N9N2; Q96EI8; Q9Y307" "ALKBH3 mediated reversal of alkylation damage" "Neuroinflammation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "211355582508718338" "False" "Medium" "IsMasterProtein" "Cont_Q03247" "Apolipoprotein E OS=Bos taurus OX=9913 GN=APOE PE=1 SV=1" "0.017" "True" "1.923" "3" "1" "1" "1" "316" "36.0" "5.67" "2.05" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;extracellular matrix;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf01442" "281004" "" "APOE" "bta:281004; Q03247; Q3T006; Q5E967" "" "" "0" "0" "0.961" "0.777" "0.825" "0.641" "0.581" "0.496" "0.554" "0.601" "0.337" "44.6" "42.8" "34.7" "36.8" "28.6" "25.9" "22.1" "24.7" "26.8" "15.0" "" "" "" "" "" "" "" "" "" "" "39.5" "35.5" "30.2" "27.5" "23.8" "23.8" "18.7" "20.4" "24.6" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994823038495086157" "False" "Medium" "IsMasterProtein" "Q02040" "A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2" "0.017" "False" "1.919" "1" "1" "1" "1" "695" "80.7" "9.73" "2.97" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "8227" "ENSG00000197976; ENSG00000292343" "AKAP17A" "hsa:8227; Q02040; Q02832; Q2TB98; Q5JQ74; Q5JQ76; Q8N6U9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361129451004350538" "False" "Medium" "IsMasterProtein" "Q9H0K1" "Serine/threonine-protein kinase SIK2 OS=Homo sapiens OX=9606 GN=SIK2 PE=1 SV=1" "0.017" "False" "1.918" "1" "1" "1" "1" "926" "103.8" "6.02" "2.97" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "23235" "ENSG00000170145" "SIK2" "A8K5B8; B0YJ94; hsa:23235; O94878; Q17RV0; Q6AZE2; Q76N03; Q8NCV7; Q96CZ8; Q9H0K1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687201697740038391" "False" "Medium" "IsMasterProtein" "Q9NP92" "Large ribosomal subunit protein mL65 OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "0.017" "False" "1.914" "2" "1" "2" "1" "439" "50.3" "7.97" "4.80" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.993" "0.802" "1.027" "0.977" "0.824" "0.978" "0.855" "0.936" "1.358" "87.8" "87.2" "70.5" "90.2" "85.8" "72.4" "85.9" "75.1" "82.2" "119.3" "" "" "" "" "" "" "" "" "" "" "77.9" "72.3" "61.5" "67.5" "71.6" "66.5" "72.6" "62.1" "75.4" "119.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300831258650065566" "False" "Medium" "IsMasterProtein" "Q9P281" "BAH and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BAHCC1 PE=1 SV=4" "0.017" "False" "1.910" "0" "1" "1" "1" "2639" "279.8" "8.78" "3.00" "1" "" "" "other molecular function" "Pf01426, Pf21744" "57597" "ENSG00000266074" "BAHCC1" "A0A075B747; hsa:57597; Q5U629; Q9P281" "" "" "0" "0" "0.716" "0.763" "0.828" "0.707" "0.999" "1.008" "0.982" "0.792" "0.702" "166.6" "119.3" "127.2" "137.9" "117.8" "166.4" "167.9" "163.7" "132.0" "117.0" "" "" "" "" "" "" "" "" "" "" "147.7" "98.8" "111.0" "103.2" "98.2" "152.9" "141.9" "135.3" "121.1" "117.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084351700158867792" "False" "Medium" "IsMasterProtein" "Q9HD33" "Large ribosomal subunit protein uL29m OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "0.017" "False" "1.909" "4" "1" "1" "1" "250" "29.4" "10.37" "2.20" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229500280398030060" "False" "Medium" "IsMasterProtein" "Q9Y2E5" "Epididymis-specific alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B2 PE=1 SV=4" "0.017" "False" "1.906" "1" "1" "1" "1" "1009" "113.9" "7.24" "2.01" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf01074, Pf07748, Pf09261" "23324" "ENSG00000013288" "MAN2B2" "hsa:23324; Q66MP2; Q86T67; Q9Y2E5" "Lysosomal oligosaccharide catabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638474282161267402" "False" "Medium" "IsMasterProtein" "Q969Z0" "FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1" "0.018" "False" "1.892" "1" "1" "1" "1" "631" "70.7" "7.42" "1.93" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "9238" "ENSG00000136270" "TBRG4" "A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266136317046350400" "False" "Medium" "IsMasterProtein" "Q70Z53" "Protein FRA10AC1 OS=Homo sapiens OX=9606 GN=FRA10AC1 PE=1 SV=3" "0.018" "False" "1.891" "3" "1" "1" "1" "315" "37.5" "8.10" "3.46" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf09725" "118924" "ENSG00000148690" "FRA10AC1" "C9JCR4; C9JCR5; C9JMY4; hsa:118924; Q70Z49; Q70Z50; Q70Z51; Q70Z52; Q70Z53; Q8N293; Q8WVH5; Q96JQ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658427898063884792" "False" "Medium" "IsMasterProtein" "Q9P2N7" "Kelch-like protein 13 OS=Homo sapiens OX=9606 GN=KLHL13 PE=1 SV=3" "0.018" "False" "1.887" "2" "1" "1" "1" "655" "73.8" "6.62" "2.99" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "90293" "ENSG00000003096" "KLHL13" "B3KV78; B3KWM7; B7Z3S9; B7Z5P2; B7Z802; D3DWH6; hsa:90293; Q6P2E3; Q96QI7; Q9P2N7; Q9UDN9" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.971" "0.961" "1.032" "0.902" "0.773" "0.936" "0.819" "0.836" "1.690" "67.8" "65.8" "65.2" "69.9" "61.1" "52.4" "63.4" "55.5" "56.6" "114.5" "" "" "" "" "" "" "" "" "" "" "60.1" "54.5" "56.8" "52.3" "51.0" "48.1" "53.6" "45.9" "51.9" "114.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6446892440911293889" "False" "Medium" "IsMasterProtein" "Q5JR59" "Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=MTUS2 PE=1 SV=3" "0.018" "False" "1.887" "1" "1" "1" "1" "1369" "150.1" "6.68" "2.99" "1" "" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "23281" "ENSG00000132938" "MTUS2" "A7E292; B4DF81; O94872; Q08E97; Q5JQR3; Q5JR59; Q8N5E2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-531095149826683174" "False" "Medium" "IsMasterProtein" "Q86WX3" "Active regulator of SIRT1 OS=Homo sapiens OX=9606 GN=RPS19BP1 PE=1 SV=1" "0.018" "False" "1.886" "5" "1" "1" "1" "136" "15.4" "10.74" "2.80" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15684" "91582" "ENSG00000187051" "RPS19BP1" "B0QY96; hsa:91582; Q5JZA1; Q86WX3" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652063056633213151" "False" "Medium" "IsMasterProtein" "Q9Y4C4" "Malignant fibrous histiocytoma-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MFHAS1 PE=1 SV=2" "0.018" "False" "1.882" "1" "1" "2" "1" "1052" "116.9" "7.88" "4.88" "1" "stress response;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13855" "9258" "ENSG00000147324" "MFHAS1" "hsa:9258; Q96CI0; Q9Y4C4" "" "8p23.1 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058702091777146472" "False" "Medium" "IsMasterProtein" "Q9BQ65" "U6 snRNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=USB1 PE=1 SV=1" "0.018" "False" "1.879" "3" "1" "1" "1" "265" "30.2" "6.52" "3.25" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf09749" "79650" "ENSG00000103005" "USB1" "B4DWE3; B4DZW5; hsa:79650; Q96FZ9; Q9BQ65; Q9H8X8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8668239743978999828" "False" "Medium" "IsMasterProtein" "Q9NSI2" "Ribosome biogenesis protein SLX9 homolog OS=Homo sapiens OX=9606 GN=SLX9 PE=1 SV=2" "0.018" "False" "1.878" "6" "1" "1" "1" "230" "25.4" "11.08" "1.87" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf15341" "85395" "ENSG00000160256" "SLX9" "hsa:85395; Q9NSI2" "" "" "0" "0" "1.142" "0.756" "2.009" "1.069" "0.432" "1.239" "0.941" "0.626" "0.427" "83.3" "95.1" "63.0" "167.3" "89.0" "36.0" "103.2" "78.4" "52.1" "35.6" "" "" "" "" "" "" "" "" "" "" "73.9" "78.8" "54.9" "125.1" "74.3" "33.1" "87.2" "64.8" "47.8" "35.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7076212038765232147" "False" "Medium" "IsMasterProtein" "Q96RR1" "Twinkle mtDNA helicase OS=Homo sapiens OX=9606 GN=TWNK PE=1 SV=1" "0.018" "False" "1.870" "1" "1" "1" "1" "684" "77.1" "8.98" "0.00" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf13481" "56652" "ENSG00000107815" "TWNK" "B2CQL2; hsa:56652; Q6MZX2; Q6PJP5; Q96RR0; Q96RR1" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "Primary ovarian insufficiency" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6794455486921931885" "False" "Medium" "IsMasterProtein" "P55201" "Peregrin OS=Homo sapiens OX=9606 GN=BRPF1 PE=1 SV=2" "0.018" "False" "1.868" "2" "1" "1" "1" "1214" "137.4" "7.93" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00855, Pf10513, Pf13831, Pf13832" "7862" "ENSG00000156983" "BRPF1" "B4DEZ6; P55201; Q7Z6E0; Q8TCM6; Q9UHI0" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "1" "" "3248682762130005719" "False" "Medium" "IsMasterProtein" "Q9BQ39" "ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1" "0.019" "False" "1.863" "1" "1" "1" "1" "737" "82.5" "9.17" "0.00" "1" "" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf00270, Pf00271, Pf08152" "79009" "ENSG00000107625" "DDX50" "hsa:79009; Q5VX37; Q8WV76; Q9BQ39; Q9BWI8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3101313482394976483" "False" "Medium" "IsMasterProtein" "Q9H1U4" "Multiple epidermal growth factor-like domains protein 9 OS=Homo sapiens OX=9606 GN=MEGF9 PE=1 SV=3" "0.019" "False" "1.855" "1" "1" "1" "1" "602" "62.9" "5.67" "2.58" "1" "cell organization and biogenesis" "extracellular matrix;other membranes;other cell component" "other molecular function" "Pf00053" "1955" "ENSG00000106780" "MEGF9" "B7Z315; hsa:1955; O75098; Q9H1U4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680775627371570044" "False" "Medium" "IsMasterProtein" "Q9Y6V0" "Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5" "0.020" "False" "1.838" "0" "1" "4" "1" "5142" "560.4" "6.47" "8.61" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00168, Pf00595, Pf05715" "27445" "ENSG00000186472" "PCLO" "A4D1A7; A6NNX9; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; Q9Y6V0" "Sensory processing of sound by inner hair cells of the cochlea" "Cell lineage map for neuronal differentiation" "2" "0" "1.030" "0.910" "0.999" "0.915" "1.004" "0.784" "0.854" "0.974" "0.430" "124.2" "127.9" "113.0" "124.1" "113.6" "124.7" "97.4" "106.0" "120.9" "53.4" "" "" "" "" "" "" "" "" "" "" "110.1" "106.0" "98.6" "92.8" "94.7" "114.5" "82.3" "87.6" "110.9" "53.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485687817967320227" "False" "Medium" "IsMasterProtein" "Q96ES7" "SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1" "0.020" "False" "1.835" "4" "1" "1" "1" "293" "33.2" "8.10" "2.55" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07039" "112869" "ENSG00000176476" "SGF29" "hsa:112869; Q96ES7; Q96MF5" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "" "2" "0" "0.999" "1.124" "1.224" "1.086" "0.964" "1.152" "0.944" "1.015" "1.162" "119.8" "119.7" "134.6" "146.7" "130.1" "115.5" "138.0" "113.1" "121.7" "139.2" "" "" "" "" "" "" "" "" "" "" "106.3" "99.2" "117.5" "109.7" "108.5" "106.1" "116.7" "93.5" "111.6" "139.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159074218320120217" "False" "Medium" "IsMasterProtein" "A8MT69" "Centromere protein X OS=Homo sapiens OX=9606 GN=CENPX PE=1 SV=1" "0.020" "False" "1.834" "11" "1" "1" "1" "81" "9.0" "5.90" "3.43" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09415" "201254" "ENSG00000169689" "CENPX" "A8MT69; hsa:201254; O00281; O00282; Q96DD4; Q96F51" "Fanconi Anemia Pathway; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "DNA repair pathways, full network" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2167578291450993964" "False" "Medium" "IsMasterProtein" "Q8N697" "Solute carrier family 15 member 4 OS=Homo sapiens OX=9606 GN=SLC15A4 PE=1 SV=1" "0.020" "False" "1.829" "1" "1" "1" "1" "577" "62.0" "9.00" "2.08" "1" "stress response;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "transporter activity" "Pf00854" "121260" "ENSG00000139370" "SLC15A4" "A6H8Y9; B3KTK1; hsa:121260; Q71M34; Q7Z5F8; Q8N697; Q8TAH0" "Neutrophil degranulation; Proton/oligopeptide cotransporters" "Carnosine metabolism of glial cells" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1194949303264127271" "False" "Medium" "IsMasterProtein" "Q9NUA8" "Zinc finger and BTB domain-containing protein 40 OS=Homo sapiens OX=9606 GN=ZBTB40 PE=1 SV=4" "0.020" "False" "1.829" "1" "1" "1" "1" "1239" "138.0" "6.57" "2.31" "1" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf12874" "9923" "ENSG00000184677" "ZBTB40" "hsa:9923; O75066; Q5TFU5; Q8N1R1; Q9NUA8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599368331442673312" "False" "Medium" "IsMasterProtein" "Q8WWY8" "Lipase member H OS=Homo sapiens OX=9606 GN=LIPH PE=1 SV=1" "0.020" "False" "1.824" "4" "1" "1" "1" "451" "50.8" "7.42" "2.56" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00151" "200879" "ENSG00000163898" "LIPH" "A2IBA7; hsa:200879; Q8TEC7; Q8WWY8" "Synthesis of PA" "" "1" "0" "1.050" "1.034" "1.077" "1.048" "0.917" "1.118" "0.939" "1.029" "0.757" "101.4" "106.5" "104.9" "109.1" "106.2" "93.0" "113.3" "95.2" "104.3" "76.8" "" "" "" "" "" "" "" "" "" "" "89.9" "88.2" "91.5" "81.6" "88.6" "85.4" "95.8" "78.7" "95.6" "76.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5712517081782202986" "False" "Medium" "IsMasterProtein" "Q86V48" "Leucine zipper protein 1 OS=Homo sapiens OX=9606 GN=LUZP1 PE=1 SV=2" "0.020" "False" "1.824" "1" "1" "1" "1" "1076" "120.2" "8.50" "2.73" "1" "developmental processes" "cytoskeleton;nucleus;other cell component" "" "" "7798" "ENSG00000169641" "LUZP1" "hsa:7798; Q5TH93; Q86V48; Q8N4X3; Q8TEH1" "" "Orexin receptor pathway" "1" "0" "0.956" "0.874" "0.880" "0.923" "0.916" "0.859" "0.943" "0.914" "0.648" "143.5" "137.2" "125.5" "126.2" "132.5" "131.4" "123.2" "135.3" "131.2" "93.0" "" "" "" "" "" "" "" "" "" "" "127.3" "113.7" "109.5" "94.4" "110.5" "120.7" "104.1" "111.9" "120.3" "93.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958262542107945679" "False" "Medium" "IsMasterProtein" "Q96C00" "Zinc finger and BTB domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ZBTB9 PE=1 SV=1" "0.020" "False" "1.822" "3" "1" "1" "1" "473" "50.6" "6.76" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00651" "221504" "ENSG00000213588; ENSG00000236515" "ZBTB9" "A2AB19; hsa:221504; Q96C00" "" "" "0" "0" "0.814" "1.101" "0.879" "0.708" "0.816" "0.959" "0.789" "0.697" "0.405" "149.9" "122.0" "164.9" "131.8" "106.1" "122.2" "143.8" "118.2" "104.5" "60.7" "" "" "" "" "" "" "" "" "" "" "132.9" "101.1" "143.9" "98.5" "88.5" "112.3" "121.5" "97.7" "95.8" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9180355309392093096" "False" "Medium" "IsMasterProtein" "Q6NV74" "CRACD-like protein OS=Homo sapiens OX=9606 GN=CRACDL PE=1 SV=3" "0.020" "False" "1.820" "1" "1" "1" "1" "962" "102.1" "7.96" "2.35" "1" "" "" "" "Pf15262" "343990" "ENSG00000196872" "CRACDL" "Q6NV74" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8754734411753965302" "False" "Medium" "IsMasterProtein" "P19823" "Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2" "0.020" "False" "1.814" "1" "1" "1" "1" "946" "106.4" "6.86" "2.33" "1" "other metabolic processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00092, Pf06668, Pf08487" "3698" "ENSG00000151655" "ITIH2" "hsa:3698; P19823; Q14659; Q15484; Q5T986" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7340986186018177511" "False" "Medium" "IsMasterProtein" "P05496" "ATP synthase F(0) complex subunit C1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MC1 PE=1 SV=2" "0.021" "False" "1.811" "5" "1" "1" "1" "136" "14.3" "9.74" "3.56" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00137" "516" "ENSG00000159199" "ATP5MC1" "hsa:516; P05496" "Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5621842442587442909" "False" "Medium" "IsMasterProtein" "Q6ZNA5" "Ferric-chelate reductase 1 OS=Homo sapiens OX=9606 GN=FRRS1 PE=1 SV=2" "0.021" "False" "1.810" "1" "1" "1" "1" "592" "66.1" "7.47" "2.78" "1" "other biological processes" "other membranes" "other molecular function" "Pf02014, Pf03351" "391059" "ENSG00000156869" "FRRS1" "A6NLN7; hsa:391059; Q6ZNA5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7301456803805066083" "False" "Medium" "IsMasterProtein" "Q8IWK6" "Adhesion G protein-coupled receptor A3 OS=Homo sapiens OX=9606 GN=ADGRA3 PE=1 SV=2" "0.021" "False" "1.809" "1" "1" "1" "1" "1321" "146.1" "8.48" "2.05" "1" "signal transduction" "plasma membrane;other membranes" "other molecular function" "Pf00002, Pf01825, Pf13855" "166647" "ENSG00000152990" "ADGRA3" "hsa:166647; Q6UXK9; Q86SQ5; Q8IWK6; Q8TC55" "" "" "0" "0" "0.728" "1.054" "0.861" "0.884" "1.003" "0.886" "0.976" "1.056" "0.871" "159.6" "116.1" "168.2" "137.5" "141.2" "160.1" "141.4" "155.7" "168.5" "139.1" "" "" "" "" "" "" "" "" "" "" "141.5" "96.2" "146.7" "102.8" "117.7" "147.0" "119.5" "128.7" "154.5" "139.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5150422290065042412" "False" "Medium" "IsMasterProtein" "Q9BXL5" "Hemogen OS=Homo sapiens OX=9606 GN=HEMGN PE=1 SV=1" "0.021" "False" "1.808" "1" "1" "1" "1" "484" "55.3" "4.87" "2.13" "1" "other biological processes" "nucleus" "" "" "55363" "ENSG00000136929" "HEMGN" "hsa:55363; Q6XAR3; Q86XY5; Q9BXL5; Q9NPC0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8178956368913015383" "False" "Medium" "IsMasterProtein" "Q0D2K0" "Magnesium transporter NIPA4 OS=Homo sapiens OX=9606 GN=NIPAL4 PE=1 SV=4" "0.021" "False" "1.805" "2" "1" "2" "1" "404" "44.0" "7.42" "1.85" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf05653" "348938" "ENSG00000172548" "NIPAL4" "A8S6F1; A8S6F5; A8S6F8; B4DLF3; hsa:348938; Q0D2J8; Q0D2J9; Q0D2K0" "Miscellaneous transport and binding events" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6613214644260606221" "False" "Medium" "IsMasterProtein" "Q9NUN5" "Lysosomal cobalamin transport escort protein LMBD1 OS=Homo sapiens OX=9606 GN=LMBRD1 PE=1 SV=1" "0.021" "False" "1.805" "1" "1" "1" "1" "540" "61.3" "7.77" "2.89" "1" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf04791" "55788" "ENSG00000168216" "LMBRD1" "A8K204; E1P531; hsa:55788; Q5VUN6; Q86Y70; Q96FW4; Q9BY56; Q9NUN5; Q9NZD6" "Defective ABCD4 causes MAHCJ; Uptake of dietary cobalamins into enterocytes; Transport of RCbl within the body" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4320196251115137643" "False" "Medium" "IsMasterProtein" "O43405" "Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1" "0.021" "False" "1.805" "1" "1" "1" "1" "550" "59.4" "7.96" "2.68" "1" "other biological processes" "non-structural extracellular;extracellular matrix" "other molecular function" "Pf00092, Pf03815" "1690" "ENSG00000100473" "COCH" "A8K9K9; D3DS84; hsa:1690; O43405; Q96IU6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7426344905124172545" "False" "Medium" "IsMasterProtein" "Q9BR61" "Acyl-CoA-binding domain-containing protein 6 OS=Homo sapiens OX=9606 GN=ACBD6 PE=1 SV=1" "0.021" "False" "1.804" "2" "1" "1" "1" "282" "31.1" "5.11" "3.44" "1" "" "cytosol" "other molecular function" "Pf00887, Pf12796" "84320" "ENSG00000230124" "ACBD6" "hsa:84320; Q9BR61" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.089" "1.092" "1.095" "1.043" "1.060" "1.049" "0.775" "1.070" "6.682" "174.7" "190.3" "190.8" "191.3" "182.2" "185.3" "183.2" "135.3" "187.0" "1167.3" "" "" "" "" "" "" "" "" "" "" "154.9" "157.6" "166.5" "143.1" "151.9" "170.2" "154.8" "111.9" "171.5" "1167.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-50216324181506219" "False" "Medium" "IsMasterProtein" "Q9H4M7" "Pleckstrin homology domain-containing family A member 4 OS=Homo sapiens OX=9606 GN=PLEKHA4 PE=1 SV=2" "0.021" "False" "1.804" "2" "1" "1" "1" "779" "85.3" "10.56" "3.09" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00169" "57664" "ENSG00000105559" "PLEKHA4" "hsa:57664; Q8N4M8; Q8N658; Q9H4M7" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902491822041770451" "False" "Medium" "IsMasterProtein" "O95685" "Protein phosphatase 1 regulatory subunit 3D OS=Homo sapiens OX=9606 GN=PPP1R3D PE=1 SV=1" "0.022" "False" "1.802" "3" "1" "2" "1" "299" "32.5" "8.07" "2.89" "1" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf03370" "5509" "ENSG00000132825" "PPP1R3D" "hsa:5509; O95685; Q6DK02" "" "" "0" "0" "1.032" "0.923" "1.129" "0.935" "0.967" "1.041" "0.872" "1.137" "2.166" "71.9" "74.3" "66.4" "81.2" "67.2" "69.6" "74.9" "62.7" "81.8" "155.8" "" "" "" "" "" "" "" "" "" "" "63.8" "61.5" "58.0" "60.8" "56.1" "63.9" "63.3" "51.8" "75.0" "155.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355832090730620748" "False" "Medium" "IsMasterProtein" "Q03169" "Tumor necrosis factor alpha-induced protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP2 PE=1 SV=2" "0.022" "False" "1.798" "1" "1" "1" "1" "654" "72.6" "6.46" "3.12" "1" "transport;developmental processes;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf06046" "7127" "ENSG00000185215" "TNFAIP2" "hsa:7127; Q03169; Q86VI0" "" "IL-18 signaling pathway" "1" "0" "0.821" "0.819" "0.760" "0.651" "0.816" "0.902" "0.798" "0.820" "0.332" "212.5" "174.4" "174.1" "161.4" "138.3" "173.5" "191.7" "169.6" "174.2" "70.6" "" "" "" "" "" "" "" "" "" "" "188.4" "144.5" "151.9" "120.7" "115.3" "159.3" "162.0" "140.2" "159.8" "70.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5583069531620115557" "False" "Medium" "IsMasterProtein" "Q2M3G4" "Protein Shroom1 OS=Homo sapiens OX=9606 GN=SHROOM1 PE=1 SV=1" "0.022" "False" "1.794" "1" "1" "1" "1" "852" "90.7" "6.15" "2.40" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf08687, Pf08688" "134549" "ENSG00000164403" "SHROOM1" "B7WP40; B7ZL01; hsa:134549; Q2M3G4; Q8TDP0; Q8TF41" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5170964613395918541" "False" "Medium" "IsMasterProtein" "Q8NC24" "RELT-like protein 2 OS=Homo sapiens OX=9606 GN=RELL2 PE=1 SV=1" "0.022" "False" "1.782" "2" "1" "1" "1" "303" "32.4" "6.90" "2.79" "1" "other biological processes" "extracellular matrix;plasma membrane;other membranes" "other molecular function" "Pf12606" "285613" "ENSG00000164620" "RELL2" "D3DQE2; hsa:285613; Q6P4E7; Q6UXY2; Q8NC24" "" "" "0" "0" "1.163" "0.986" "1.095" "0.942" "0.938" "1.024" "0.910" "1.083" "0.841" "134.0" "155.8" "132.1" "146.8" "126.3" "125.8" "137.2" "122.0" "145.1" "112.7" "" "" "" "" "" "" "" "" "" "" "118.9" "129.1" "115.3" "109.8" "105.3" "115.5" "116.0" "100.8" "133.1" "112.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6396845313695786371" "False" "Medium" "IsMasterProtein" "Q8NDX5" "Polyhomeotic-like protein 3 OS=Homo sapiens OX=9606 GN=PHC3 PE=1 SV=1" "0.022" "False" "1.780" "1" "1" "1" "1" "983" "106.1" "6.62" "2.69" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00536, Pf21319" "80012" "ENSG00000173889" "PHC3" "A2RRP9; hsa:80012; Q5HYF0; Q6NSG2; Q8NDX5; Q8NFT7; Q8NFZ1; Q8TBM2; Q9H971; Q9H9I4" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "" "9" "0" "1.175" "1.104" "0.827" "0.902" "1.064" "0.926" "0.940" "0.934" "2.331" "19.2" "22.6" "21.2" "15.9" "17.3" "20.5" "17.8" "18.1" "17.9" "44.8" "" "" "" "" "" "" "" "" "" "" "17.0" "18.7" "18.5" "11.9" "14.5" "18.8" "15.0" "14.9" "16.5" "44.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6011975362988594492" "False" "Medium" "IsMasterProtein" "Cont_Q3T052" "Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus OX=9913 GN=ITIH4 PE=1 SV=1" "0.022" "True" "1.780" "1" "1" "1" "1" "916" "101.4" "6.68" "0.00" "1" "other metabolic processes;stress response" "non-structural extracellular" "enzyme regulator activity" "Pf00092, Pf06668, Pf08487" "513700" "" "ITIH4" "bta:513700; Q3T052" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6148676134897605043" "False" "Medium" "IsMasterProtein" "P05186" "Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4" "0.022" "False" "1.780" "2" "1" "1" "1" "524" "57.3" "6.67" "0.00" "1" "other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00245" "249" "ENSG00000162551" "ALPL" "A1A4E7; B2RMP8; B7Z387; B7Z4Y6; hsa:249; O75090; P05186; Q2TAI7; Q59EJ7; Q5BKZ5; Q5VTG5; Q6NZI8; Q8WU32; Q9UBK0" "Post-translational modification: synthesis of GPI-anchored proteins" "AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); NOTCH1 regulation of endothelial cell calcification; OSX and miRNAs in tooth development; Vitamin B6-dependent and responsive disorders; Endochondral ossification; Netrin-UNC5B signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Endochondral ossification with skeletal dysplasias" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3531951912742516330" "False" "Medium" "IsMasterProtein" "Q14643" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 OS=Homo sapiens OX=9606 GN=ITPR1 PE=1 SV=3" "0.022" "False" "1.779" "1" "1" "1" "1" "2758" "313.7" "6.04" "2.62" "1" "cell-cell signaling;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3708" "ENSG00000150995" "ITPR1" "E7EPX7; E9PDE9; hsa:3708; Q14643; Q14660; Q99897" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; cGMP effects; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Vitamin D-sensitive calcium signaling in depression; PKC-gamma calcium signaling pathway in ataxia; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; STING pathway in Kawasaki-like disease and COVID-19; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; 15q25 copy number variation; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "35" "0" "1.098" "0.966" "1.198" "0.987" "0.903" "1.158" "0.981" "1.033" "0.429" "116.2" "127.6" "112.3" "139.2" "114.7" "105.0" "134.6" "114.1" "120.0" "49.9" "" "" "" "" "" "" "" "" "" "" "103.1" "105.7" "98.0" "104.1" "95.6" "96.4" "113.7" "94.3" "110.1" "49.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4738294880547824619" "False" "Medium" "IsMasterProtein" "Q9BQ15" "SOSS complex subunit B1 OS=Homo sapiens OX=9606 GN=NABP2 PE=1 SV=1" "0.022" "False" "1.778" "3" "1" "1" "1" "211" "22.3" "9.06" "1.70" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21473" "79035" "ENSG00000139579" "NABP2" "A6NDF8; hsa:79035; Q6XYC8; Q9BQ15" "RNA polymerase II transcribes snRNA genes" "Mesodermal commitment pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7542471958177645128" "False" "Medium" "IsMasterProtein" "Q8TBC3" "SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2" "0.022" "False" "1.775" "2" "1" "1" "1" "707" "76.3" "8.28" "3.39" "1" "cell organization and biogenesis;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf02214" "92799" "ENSG00000160410" "SHKBP1" "Q8N2I6; Q8TBC3; Q8WY93; Q96IB8" "CDC42 GTPase cycle" "" "1" "0" "1.110" "0.770" "0.971" "1.108" "1.104" "0.980" "0.820" "1.186" "1.586" "44.9" "49.8" "34.6" "43.6" "49.7" "49.5" "44.0" "36.8" "53.2" "71.2" "" "" "" "" "" "" "" "" "" "" "39.8" "41.3" "30.2" "32.6" "41.4" "45.5" "37.2" "30.4" "48.8" "71.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9101384525569952634" "False" "Medium" "IsMasterProtein" "Q9BZF1" "Oxysterol-binding protein-related protein 8 OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=3" "0.022" "False" "1.774" "1" "1" "1" "1" "889" "101.1" "6.96" "3.29" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114882" "ENSG00000091039" "OSBPL8" "A8K1T2; E9PE66; E9PE68; hsa:114882; Q52LQ3; Q68D75; Q8WXP8; Q9BZF1; Q9P277" "Acyl chain remodelling of PS" "" "1" "0" "0.978" "0.808" "0.755" "0.698" "0.576" "0.536" "0.738" "0.816" "0.625" "470.6" "460.4" "380.1" "355.1" "328.3" "271.0" "252.1" "347.4" "384.0" "294.2" "" "" "" "" "" "" "" "" "" "" "417.3" "381.4" "331.6" "265.6" "273.7" "249.0" "213.1" "287.2" "352.2" "294.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980978827116582562" "False" "Medium" "IsMasterProtein" "Q07889" "Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1" "0.022" "False" "1.773" "1" "1" "1" "1" "1333" "152.4" "6.84" "2.31" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00617, Pf00618, Pf00621" "6654" "ENSG00000115904" "SOS1" "A8K2G3; B4DXG2; hsa:6654; Q07889" "RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Acute myeloid leukemia; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "120" "0" "1.257" "0.830" "1.107" "1.083" "1.042" "0.769" "0.778" "1.050" "4.985" "45.0" "56.6" "37.4" "49.8" "48.8" "46.9" "34.6" "35.0" "47.2" "224.4" "" "" "" "" "" "" "" "" "" "" "39.9" "46.9" "32.6" "37.3" "40.7" "43.1" "29.3" "29.0" "43.3" "224.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5383646713429999886" "False" "Medium" "IsMasterProtein" "Q96GC6" "Neurotrophin receptor-interacting factor homolog OS=Homo sapiens OX=9606 GN=ZNF274 PE=1 SV=2" "0.022" "False" "1.771" "1" "1" "1" "1" "653" "74.1" "6.74" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf02023" "10782" "ENSG00000171606" "ZNF274" "hsa:10782; Q53XU4; Q6MZG1; Q8WY37; Q8WY38; Q92969; Q96GC6; Q9UII0; Q9UII1" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8593755170917475749" "False" "Medium" "IsMasterProtein" "P53803" "DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1" "0.023" "False" "1.768" "12" "1" "1" "1" "58" "7.0" "9.06" "2.61" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf03604" "5440" "ENSG00000147669" "POLR2K" "hsa:5440; P53803; Q6IBD4" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; Cytosolic sensors of pathogen-associated DNA ; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4312108308025671748" "False" "Medium" "IsMasterProtein" "Q93070" "Ecto-ADP-ribosyltransferase 4 OS=Homo sapiens OX=9606 GN=ART4 PE=1 SV=3" "0.023" "False" "1.755" "2" "1" "1" "1" "314" "35.9" "9.13" "2.62" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01129" "420" "ENSG00000111339" "ART4" "hsa:420; Q93070; Q9BZ50; Q9BZ51; Q9HB06" "Post-translational modification: synthesis of GPI-anchored proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8270070607048707079" "False" "Medium" "IsMasterProtein" "Q7Z7N9" "Transmembrane protein 179B OS=Homo sapiens OX=9606 GN=TMEM179B PE=1 SV=1" "0.023" "False" "1.746" "5" "1" "1" "1" "219" "23.5" "7.85" "3.51" "1" "" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle" "" "" "374395" "ENSG00000185475" "TMEM179B" "hsa:374395; Q7Z7N9" "Neutrophil degranulation" "" "1" "0" "0.985" "0.991" "0.966" "0.930" "0.920" "0.992" "0.907" "1.066" "0.815" "268.8" "264.7" "266.5" "259.8" "249.9" "247.2" "266.7" "243.7" "286.6" "219.1" "" "" "" "" "" "" "" "" "" "" "238.4" "219.2" "232.5" "194.3" "208.4" "227.1" "225.4" "201.4" "262.9" "219.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692621720317266464" "False" "Medium" "IsMasterProtein" "P17098" "Zinc finger protein 8 OS=Homo sapiens OX=9606 GN=ZNF8 PE=1 SV=2" "0.023" "False" "1.741" "2" "1" "1" "1" "575" "64.9" "7.39" "0.00" "1" "signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "7554" "ENSG00000278129" "ZNF8" "hsa:7554; P17098; Q6PI99" "" "" "0" "0" "0.984" "0.907" "0.666" "0.589" "0.629" "0.374" "0.978" "0.986" "0.591" "15.2" "14.9" "13.7" "10.1" "8.9" "9.5" "5.7" "14.8" "15.0" "9.0" "" "" "" "" "" "" "" "" "" "" "13.4" "12.4" "12.0" "7.6" "7.5" "8.8" "4.8" "12.3" "13.7" "9.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769087556665891581" "False" "Medium" "IsMasterProtein" "P35556" "Fibrillin-2 OS=Homo sapiens OX=9606 GN=FBN2 PE=1 SV=3" "0.023" "False" "1.741" "0" "1" "12" "1" "2912" "314.6" "4.86" "0.00" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00683, Pf07645, Pf12661, Pf12662, Pf12947, Pf18193, Pf21364" "2201" "ENSG00000138829" "FBN2" "B4DU01; hsa:2201; P35556; Q59ES6" "Degradation of the extracellular matrix; Molecules associated with elastic fibres" "Hypothesized pathways in pathogenesis of cardiovascular disease" "4" "0" "1.142" "1.185" "1.142" "1.127" "1.205" "1.209" "1.216" "1.216" "0.586" "267.1" "305.1" "316.5" "305.0" "301.1" "322.0" "322.9" "324.8" "324.8" "156.4" "" "" "" "" "" "" "" "" "" "" "236.9" "252.8" "276.2" "228.1" "251.1" "295.8" "272.9" "268.5" "297.9" "156.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6787199481091963945" "False" "Medium" "IsMasterProtein" "P04053" "DNA nucleotidylexotransferase OS=Homo sapiens OX=9606 GN=DNTT PE=1 SV=3" "0.023" "False" "1.734" "3" "1" "1" "1" "509" "58.5" "8.43" "1.73" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01909, Pf10391, Pf14716, Pf14791" "1791" "ENSG00000107447" "DNTT" "hsa:1791; P04053; Q53FH1; Q5W103; Q96E50" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2653046833350144460" "False" "Medium" "IsMasterProtein" "Q96JZ2" "Hematopoietic SH2 domain-containing protein OS=Homo sapiens OX=9606 GN=HSH2D PE=1 SV=1" "0.023" "False" "1.731" "4" "1" "2" "1" "352" "39.0" "7.11" "0.00" "1" "signal transduction" "nucleus;other cell component" "" "Pf00017" "84941" "ENSG00000196684" "HSH2D" "B5ME72; hsa:84941; Q6ZNG7; Q96JZ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "1" "" "5498683654784928386" "False" "Medium" "IsMasterProtein" "Q99541" "Perilipin-2 OS=Homo sapiens OX=9606 GN=PLIN2 PE=1 SV=2" "0.023" "False" "1.729" "2" "1" "1" "1" "437" "48.0" "6.80" "2.90" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03036" "123" "ENSG00000147872" "PLIN2" "hsa:123; Q99541; Q9BSC3" "PPARA activates gene expression; Late endosomal microautophagy; Lipophagy; Chaperone Mediated Autophagy" "Adipogenesis" "5" "0" "0.974" "0.985" "0.866" "0.909" "0.950" "0.932" "0.902" "0.957" "2.100" "172.2" "167.7" "169.6" "149.2" "156.5" "163.6" "160.5" "155.3" "164.7" "361.6" "" "" "" "" "" "" "" "" "" "" "152.7" "138.9" "148.0" "111.6" "130.5" "150.3" "135.6" "128.4" "151.1" "361.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529217331400882174" "False" "Medium" "IsMasterProtein" "Q8TC05" "Nuclear protein MDM1 OS=Homo sapiens OX=9606 GN=MDM1 PE=1 SV=2" "0.023" "False" "1.728" "1" "1" "1" "1" "714" "80.7" "9.11" "2.78" "1" "developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15501" "56890" "ENSG00000111554" "MDM1" "B4DM65; E7EPQ3; hsa:56890; O43406; Q8TC05; Q8WTV9; Q9NR04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3216762708121930784" "False" "Medium" "IsMasterProtein" "Q75N03" "E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1" "0.023" "False" "1.717" "2" "1" "1" "1" "491" "54.5" "8.29" "3.46" "1" "cell adhesion;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf18408" "79872" "ENSG00000105879" "CBLL1" "B7ZM03; Q75N03; Q8TAJ4; Q9H5S6" "InlA-mediated entry of Listeria monocytogenes into host cells" "" "1" "0" "1.019" "0.955" "0.983" "1.019" "0.973" "0.997" "1.023" "1.043" "1.174" "348.3" "355.0" "332.6" "342.3" "354.8" "339.0" "347.4" "356.4" "363.4" "408.9" "" "" "" "" "" "" "" "" "" "" "308.9" "294.1" "290.2" "256.0" "295.8" "311.4" "293.6" "294.6" "333.3" "408.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5037587116329187279" "False" "Medium" "IsMasterProtein" "Q8N0U4" "Protein FAM185A OS=Homo sapiens OX=9606 GN=FAM185A PE=1 SV=3" "0.023" "False" "1.717" "2" "1" "1" "1" "392" "42.3" "7.97" "2.01" "1" "" "" "" "Pf13349" "222234" "ENSG00000222011" "FAM185A" "A8MUR7; B4DQD3; C9IZ91; hsa:222234; Q8N0U4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634766023329637374" "False" "Medium" "IsMasterProtein" "Q9HAF1" "Chromatin modification-related protein MEAF6 OS=Homo sapiens OX=9606 GN=MEAF6 PE=1 SV=1" "0.024" "False" "1.713" "5" "1" "1" "1" "191" "21.6" "9.32" "3.77" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf09340" "64769" "ENSG00000163875" "MEAF6" "B1AK64; hsa:64769; Q4F967; Q7Z311; Q86WE3; Q9HAF1" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5823057819559300912" "False" "Medium" "IsMasterProtein" "O15230" "Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8" "0.024" "False" "1.705" "0" "1" "1" "1" "3695" "399.5" "7.02" "3.02" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "signal transduction activity or receptor binding" "Pf00052, Pf00053, Pf00054, Pf00055, Pf02210, Pf06008, Pf06009" "3911" "ENSG00000130702" "LAMA5" "hsa:3911; O15230; Q5U4N9; Q8TDF8; Q8WZA7; Q9H1P1" "Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling" "Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Pleural mesothelioma" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2658794876208962167" "False" "Medium" "IsMasterProtein" "Q9Y2D9" "Zinc finger protein 652 OS=Homo sapiens OX=9606 GN=ZNF652 PE=1 SV=3" "0.024" "False" "1.703" "1" "1" "1" "1" "606" "69.7" "8.65" "3.32" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "22834" "ENSG00000198740" "ZNF652" "A4QPD9; hsa:22834; Q5H9Q0; Q9Y2D9" "" "" "0" "0" "0.988" "1.016" "0.988" "1.049" "1.173" "0.981" "0.918" "1.047" "1.224" "373.8" "369.3" "379.8" "369.1" "391.9" "438.6" "366.8" "343.2" "391.4" "457.3" "" "" "" "" "" "" "" "" "" "" "331.4" "305.9" "331.4" "276.0" "326.8" "402.9" "310.0" "283.7" "358.9" "457.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "465577355447641412" "False" "Medium" "IsMasterProtein" "Q16515" "Acid-sensing ion channel 2 OS=Homo sapiens OX=9606 GN=ASIC2 PE=1 SV=1" "0.024" "False" "1.701" "1" "1" "1" "1" "512" "57.7" "5.19" "1.74" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00858" "40" "ENSG00000108684" "ASIC2" "E9PBX2; hsa:40; Q13553; Q16515; Q6DJU1; Q8N3E2" "Stimuli-sensing channels" "17q12 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5852345656663566721" "False" "Medium" "IsMasterProtein" "Q5JSL3" "Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2" "0.024" "False" "1.700" "1" "1" "1" "1" "2073" "237.5" "7.74" "2.04" "1" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "139818" "ENSG00000147251" "DOCK11" "A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "" "3" "0" "0.987" "0.901" "0.999" "1.024" "1.016" "0.863" "0.854" "0.936" "0.580" "116.3" "114.9" "104.8" "116.2" "119.1" "118.3" "100.4" "99.4" "108.9" "67.5" "" "" "" "" "" "" "" "" "" "" "103.2" "95.2" "91.4" "86.9" "99.3" "108.6" "84.9" "82.1" "99.9" "67.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6544422487784178027" "False" "Medium" "IsMasterProtein" "Q8IVW6" "AT-rich interactive domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ARID3B PE=1 SV=2" "0.024" "False" "1.695" "1" "1" "1" "1" "561" "60.6" "7.52" "2.47" "1" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01388" "10620" "ENSG00000179361" "ARID3B" "hsa:10620; O95443; Q59HC9; Q6P9C9; Q8IVW6" "" "" "0" "0" "1.033" "0.956" "1.020" "1.005" "0.937" "0.777" "0.654" "1.043" "7.281" "69.0" "71.3" "66.0" "70.4" "69.4" "64.7" "53.7" "45.1" "72.0" "502.6" "" "" "" "" "" "" "" "" "" "" "61.2" "59.1" "57.6" "52.6" "57.9" "59.4" "45.4" "37.3" "66.0" "502.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "698567651492244617" "False" "Medium" "IsMasterProtein" "Q96RL7" "Intermembrane lipid transfer protein VPS13A OS=Homo sapiens OX=9606 GN=VPS13A PE=1 SV=2" "0.024" "False" "1.694" "0" "1" "1" "1" "3174" "360.0" "6.33" "1.99" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "23230" "ENSG00000197969" "VPS13A" "hsa:23230; Q5JSX9; Q5JSY0; Q5VYR5; Q702P4; Q709D0; Q86YF8; Q96RL7; Q96S61; Q9H995; Q9Y2J1" "" "" "0" "0" "0.931" "0.835" "0.846" "1.039" "0.786" "0.892" "0.869" "0.856" "0.510" "48.9" "45.5" "40.8" "41.4" "50.8" "38.4" "43.6" "42.5" "41.8" "24.9" "" "" "" "" "" "" "" "" "" "" "43.4" "37.7" "35.6" "30.9" "42.4" "35.3" "36.9" "35.1" "38.4" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6307327202540880647" "False" "Medium" "IsMasterProtein" "Q6IPR1" "Electron transfer flavoprotein regulatory factor 1 OS=Homo sapiens OX=9606 GN=ETFRF1 PE=1 SV=2" "0.024" "False" "1.692" "8" "1" "1" "1" "90" "10.9" "9.92" "3.03" "1" "other metabolic processes" "mitochondrion" "" "Pf05347" "144363" "ENSG00000205707" "ETFRF1" "hsa:144363; J3KPI7; Q6IPR1" "" "" "0" "0" "0.875" "0.912" "0.886" "0.802" "1.065" "0.834" "0.950" "1.041" "0.460" "333.1" "291.6" "303.9" "295.1" "267.1" "354.7" "277.9" "316.6" "346.7" "153.4" "" "" "" "" "" "" "" "" "" "" "295.4" "241.5" "265.2" "220.7" "222.8" "325.8" "234.9" "261.7" "318.0" "153.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658757101665122516" "False" "Medium" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "0.024" "False" "1.690" "1" "1" "1" "1" "559" "62.9" "7.36" "3.07" "1" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "TBC/RABGAPs" "" "1" "0" "1.043" "0.902" "1.098" "0.919" "0.826" "1.228" "1.079" "0.996" "1.262" "235.9" "246.2" "212.9" "259.1" "216.9" "195.0" "289.7" "254.6" "235.0" "297.7" "" "" "" "" "" "" "" "" "" "" "209.2" "203.9" "185.8" "193.7" "180.8" "179.1" "244.8" "210.5" "215.5" "297.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832675095304565644" "False" "Medium" "IsMasterProtein" "Q8IY26" "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 OS=Homo sapiens OX=9606 GN=PLPP6 PE=1 SV=3" "0.024" "False" "1.686" "3" "1" "1" "1" "295" "32.2" "9.99" "2.24" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf01569" "403313" "ENSG00000205808" "PLPP6" "B3KY05; hsa:403313; Q5JVJ6; Q8IY26; Q8NCK9" "Cholesterol biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3680816115405291805" "False" "Medium" "IsMasterProtein" "Q13608" "Peroxisomal ATPase PEX6 OS=Homo sapiens OX=9606 GN=PEX6 PE=1 SV=2" "0.024" "False" "1.672" "3" "1" "1" "1" "980" "104.0" "6.34" "3.77" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00004" "5190" "ENSG00000124587" "PEX6" "hsa:5190; Q13608; Q5T8W1; Q8WYQ0; Q8WYQ1; Q8WYQ2; Q99476" "Peroxisomal protein import" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "Medium" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.024" "False" "1.672" "6" "1" "1" "1" "115" "12.4" "4.37" "2.63" "1" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "" "17q12 copy number variation syndrome" "1" "0" "1.172" "1.010" "1.072" "1.097" "1.217" "1.057" "1.082" "1.112" "0.923" "71.2" "83.4" "71.9" "76.3" "78.1" "86.6" "75.2" "77.0" "79.2" "65.7" "" "" "" "" "" "" "" "" "" "" "63.1" "69.1" "62.7" "57.0" "65.1" "79.6" "63.6" "63.6" "72.6" "65.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2959240628104392196" "False" "Medium" "IsMasterProtein" "P57086" "SCAN domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCAND1 PE=1 SV=1" "0.024" "False" "1.661" "4" "1" "1" "1" "179" "19.1" "9.69" "2.78" "1" "other biological processes" "nucleus" "" "Pf02023" "51282" "ENSG00000171222" "SCAND1" "hsa:51282; P57086; Q6IAG7" "" "" "0" "0" "1.137" "0.987" "1.075" "0.937" "0.795" "0.956" "1.068" "0.957" "1.712" "129.0" "146.7" "127.2" "138.7" "120.9" "102.6" "123.3" "137.7" "123.5" "220.8" "" "" "" "" "" "" "" "" "" "" "114.4" "121.5" "111.0" "103.7" "100.8" "94.2" "104.2" "113.8" "113.2" "220.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177131133338512997" "False" "Medium" "IsMasterProtein" "Q8IXM3" "Large ribosomal subunit protein mL41 OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "0.024" "False" "1.660" "5" "1" "1" "1" "137" "15.4" "9.57" "2.46" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.901" "0.861" "0.771" "0.883" "0.821" "0.960" "0.876" "0.877" "2.078" "148.8" "134.0" "128.2" "114.7" "131.4" "122.1" "142.8" "130.3" "130.4" "309.1" "" "" "" "" "" "" "" "" "" "" "131.9" "111.0" "111.8" "85.8" "109.6" "112.2" "120.7" "107.7" "119.6" "309.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6345018063105680021" "False" "Medium" "IsMasterProtein" "Q96J88" "Epithelial-stromal interaction protein 1 OS=Homo sapiens OX=9606 GN=EPSTI1 PE=1 SV=2" "0.025" "False" "1.654" "2" "1" "1" "1" "318" "36.8" "9.89" "2.92" "1" "" "" "" "" "94240" "ENSG00000133106" "EPSTI1" "hsa:94240; Q8IVC7; Q8NDQ7; Q96J88" "RND1 GTPase cycle" "Male infertility" "2" "0" "2.299" "0.894" "1.350" "1.292" "1.360" "1.184" "0.839" "1.172" "0.707" "241.8" "555.9" "216.2" "326.4" "312.3" "328.9" "286.3" "202.9" "283.4" "170.9" "" "" "" "" "" "" "" "" "" "" "214.4" "460.5" "188.6" "244.1" "260.5" "302.1" "242.0" "167.7" "259.9" "170.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7769023371860008745" "False" "Medium" "IsMasterProtein" "Q8N5I2" "Arrestin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARRDC1 PE=1 SV=1" "0.025" "False" "1.652" "2" "1" "1" "1" "433" "46.0" "7.02" "2.51" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00339, Pf02752" "92714" "ENSG00000197070" "ARRDC1" "hsa:92714; Q8N5I2" "" "" "0" "0" "1.050" "1.016" "1.101" "1.227" "0.962" "1.199" "1.076" "0.919" "0.837" "73.6" "77.2" "74.8" "81.0" "90.3" "70.8" "88.2" "79.1" "67.6" "61.6" "" "" "" "" "" "" "" "" "" "" "65.2" "64.0" "65.2" "60.6" "75.3" "65.0" "74.6" "65.4" "62.0" "61.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7824076810458492012" "False" "Medium" "IsMasterProtein" "P05165" "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4" "0.025" "False" "1.644" "1" "1" "1" "1" "728" "80.0" "7.52" "2.64" "1" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786, Pf18140" "5095" "ENSG00000175198" "PCCA" "B4DKY8; B4DPF9; C9JPQ8; hsa:5095; P05165; Q15979; Q8WXQ7" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "Primary ovarian insufficiency" "4" "0" "1.247" "1.419" "1.107" "0.868" "0.443" "0.931" "1.033" "0.758" "0.470" "268.4" "334.7" "380.8" "297.2" "232.9" "118.8" "249.8" "277.3" "203.6" "126.0" "" "" "" "" "" "" "" "" "" "" "238.0" "277.3" "332.3" "222.3" "194.2" "109.2" "211.1" "229.2" "186.7" "126.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300467232994524401" "False" "Medium" "IsMasterProtein" "Q8NBX0" "Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens OX=9606 GN=SCCPDH PE=1 SV=1" "0.025" "False" "1.642" "2" "1" "1" "1" "429" "47.1" "9.14" "2.19" "1" "other metabolic processes" "non-structural extracellular;other cell component" "other molecular function" "Pf03435" "51097" "ENSG00000143653" "SCCPDH" "hsa:51097; Q8NBX0; Q8TAR0; Q9Y363" "Platelet degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033266282732166818" "False" "Medium" "IsMasterProtein" "Q9Y663" "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 OS=Homo sapiens OX=9606 GN=HS3ST3A1 PE=1 SV=1" "0.025" "False" "1.632" "2" "1" "1" "1" "406" "44.9" "9.50" "2.57" "1" "protein metabolism;other metabolic processes;developmental processes" "other membranes;ER/Golgi" "other molecular function" "Pf00685" "9955" "ENSG00000153976" "HS3ST3A1" "A8K7N2; hsa:9955; Q9Y663" "HS-GAG biosynthesis" "Glycosaminoglycan synthesis in fibroblasts; Metapathway biotransformation Phase I and II" "3" "0" "0.852" "0.804" "0.950" "0.835" "0.920" "1.030" "0.891" "0.693" "1.661" "76.0" "64.8" "61.1" "72.2" "63.5" "70.0" "78.3" "67.8" "52.7" "126.3" "" "" "" "" "" "" "" "" "" "" "67.4" "53.6" "53.3" "54.0" "52.9" "64.3" "66.2" "56.0" "48.3" "126.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851911761268984934" "False" "Medium" "IsMasterProtein" "O00418" "Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2" "0.025" "False" "1.632" "2" "1" "1" "1" "725" "82.1" "5.33" "3.04" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf02816" "29904" "ENSG00000103319" "EEF2K" "hsa:29904; O00418; Q8N588" "mTORC1-mediated signalling" "Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling" "4" "0" "0.929" "0.962" "0.934" "0.830" "0.895" "0.819" "0.831" "1.150" "0.425" "113.8" "105.7" "109.5" "106.3" "94.5" "101.9" "93.2" "94.6" "130.9" "48.4" "" "" "" "" "" "" "" "" "" "" "100.9" "87.6" "95.5" "79.5" "78.8" "93.6" "78.8" "78.2" "120.0" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6383247100679150488" "False" "Medium" "IsMasterProtein" "Q8TCC7" "Organic anion transporter 3 OS=Homo sapiens OX=9606 GN=SLC22A8 PE=1 SV=1" "0.026" "False" "1.621" "1" "1" "1" "1" "542" "59.8" "8.85" "2.51" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00083" "9376" "ENSG00000149452" "SLC22A8" "B4DPH7; F5GWA8; F5H5J1; hsa:9376; O95820; Q59EW9; Q8TCC7; Q96TC1" "Ciprofloxacin ADME; Organic anion transport" "Proximal tubule transport" "3" "0" "28.691" "0.787" "10.839" "8.672" "11.996" "5.668" "0.503" "7.364" "2.547" "23.1" "661.4" "18.1" "249.9" "199.9" "276.5" "130.7" "11.6" "169.8" "58.7" "" "" "" "" "" "" "" "" "" "" "20.4" "547.9" "15.8" "186.9" "166.7" "254.0" "110.4" "9.6" "155.7" "58.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5683736412661215530" "False" "Medium" "IsMasterProtein" "Q6UW56" "All-trans retinoic acid-induced differentiation factor OS=Homo sapiens OX=9606 GN=ATRAID PE=1 SV=2" "0.026" "False" "1.620" "3" "1" "1" "1" "229" "24.7" "7.25" "3.12" "1" "transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "" "51374" "ENSG00000138085" "ATRAID" "A8C1S2; A8K779; hsa:51374; Q6UW56; Q96FF6; Q96RT2; Q9Y2R7; Q9Y5L7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1210057456196531330" "False" "Medium" "IsMasterProtein" "Q9Y276" "Mitochondrial chaperone BCS1 OS=Homo sapiens OX=9606 GN=BCS1L PE=1 SV=1" "0.026" "False" "1.618" "2" "1" "1" "1" "419" "47.5" "8.50" "2.01" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "other molecular function" "Pf00004, Pf08740" "617" "ENSG00000074582" "BCS1L" "B3KTW9; hsa:617; Q7Z2V7; Q9Y276" "Mitochondrial protein import" "Mitochondrial complex III assembly; Mitochondrial immune response to SARS-CoV-2; Iron metabolism disorders; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 4p16.3 copy number variation" "6" "0" "0.913" "0.849" "0.977" "0.888" "0.932" "0.899" "0.877" "0.620" "0.391" "639.6" "583.8" "542.9" "625.1" "568.1" "596.2" "574.8" "561.1" "396.6" "250.0" "" "" "" "" "" "" "" "" "" "" "567.2" "483.6" "473.7" "467.5" "473.7" "547.7" "485.8" "463.8" "363.8" "250.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4031307080017597315" "False" "Medium" "IsMasterProtein" "P18077" "Large ribosomal subunit protein eL33 OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "0.026" "False" "1.617" "6" "1" "1" "1" "110" "12.5" "11.06" "3.85" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3915104900764818222" "False" "Medium" "IsMasterProtein" "Q86TG7" "Retrotransposon-derived protein PEG10 OS=Homo sapiens OX=9606 GN=PEG10 PE=1 SV=2" "0.026" "False" "1.614" "1" "1" "1" "1" "708" "80.1" "6.39" "2.31" "1" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16297" "23089" "ENSG00000242265" "PEG10" "B4DSP0; hsa:23089; Q86TG7; Q96A68; Q9UPV1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7789640174005982269" "False" "Medium" "IsMasterProtein" "Q9Y5R2" "Matrix metalloproteinase-24 OS=Homo sapiens OX=9606 GN=MMP24 PE=1 SV=1" "0.026" "False" "1.612" "2" "1" "1" "1" "645" "73.2" "9.23" "2.50" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00045, Pf00413, Pf01471, Pf11857" "10893" "ENSG00000125966" "MMP24" "B7ZBG8; hsa:10893; Q9H440; Q9Y5R2" "Activation of Matrix Metalloproteinases" "Matrix metalloproteinases; Chronic hyperglycemia impairment of neuron function" "3" "0" "1.107" "0.762" "0.865" "0.764" "0.719" "0.667" "0.744" "0.627" "0.483" "56.7" "62.8" "43.3" "49.1" "43.4" "40.8" "37.9" "42.2" "35.6" "27.4" "" "" "" "" "" "" "" "" "" "" "50.3" "52.1" "37.7" "36.7" "36.2" "37.5" "32.0" "34.9" "32.6" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216819493062763362" "False" "Medium" "IsMasterProtein" "O00165" "HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2" "0.026" "False" "1.611" "3" "1" "1" "1" "279" "31.6" "4.92" "2.28" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "" "10456" "ENSG00000143575" "HAX1" "A8W4W9; A8W4X0; B4DUJ7; hsa:10456; O00165; Q5VYD5; Q5VYD7; Q96AU4; Q9BS80" "" "Primary ovarian insufficiency" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5217952952055268548" "False" "Medium" "IsMasterProtein" "P49207" "Large ribosomal subunit protein eL34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "0.026" "False" "1.608" "6" "1" "2" "1" "117" "13.3" "11.47" "6.33" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.221" "0.997" "1.275" "1.227" "0.985" "1.272" "0.969" "1.013" "1.468" "254.4" "310.6" "253.7" "324.4" "312.1" "250.5" "323.6" "246.6" "257.8" "373.4" "" "" "" "" "" "" "" "" "" "" "225.6" "257.3" "221.4" "242.6" "260.2" "230.1" "273.5" "203.8" "236.4" "373.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8912838083063934850" "False" "Medium" "IsMasterProtein" "Q8TBE7" "Solute carrier family 35 member G2 OS=Homo sapiens OX=9606 GN=SLC35G2 PE=1 SV=3" "0.026" "False" "1.607" "2" "1" "1" "1" "412" "46.4" "7.34" "0.00" "1" "" "plasma membrane;other membranes;ER/Golgi" "" "Pf00892" "80723" "ENSG00000168917" "SLC35G2" "B2RA80; D3DNE1; hsa:80723; Q8TBE7; Q9BWN4; Q9H0S6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7553358112482033805" "False" "Medium" "IsMasterProtein" "O00767" "Stearoyl-CoA desaturase OS=Homo sapiens OX=9606 GN=SCD PE=1 SV=2" "0.026" "False" "1.606" "3" "1" "1" "1" "359" "41.5" "9.00" "2.41" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6319" "ENSG00000099194" "SCD" "B2R5U0; D3DR68; hsa:6319; O00767; Q16150; Q53GR9; Q5W037; Q5W038; Q6GSS4; Q96KF6; Q9BS07; Q9Y695" "Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis pathway in hepatocytes" "13" "0" "1.018" "1.073" "1.030" "1.228" "2.482" "1.073" "0.884" "1.238" "1.135" "102.7" "104.5" "110.2" "105.7" "126.1" "254.9" "110.2" "90.8" "127.1" "116.5" "" "" "" "" "" "" "" "" "" "" "91.1" "86.6" "96.2" "79.1" "105.2" "234.2" "93.1" "75.1" "116.6" "116.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5013600273074776242" "False" "Medium" "IsMasterProtein" "Q9NZ09" "Ubiquitin-associated protein 1 OS=Homo sapiens OX=9606 GN=UBAP1 PE=1 SV=1" "0.026" "False" "1.605" "4" "1" "1" "1" "502" "55.0" "5.11" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf21267" "51271" "ENSG00000165006" "UBAP1" "B7Z348; B7Z8N9; D3DRL7; F5GXE2; F5H0J8; hsa:51271; Q4V759; Q53FP7; Q5T7B3; Q6FI75; Q8NC52; Q8NCG6; Q8NCH9; Q9NZ09" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "" "5" "0" "1.013" "1.000" "1.080" "1.168" "0.950" "1.191" "1.252" "1.063" "1.144" "62.4" "63.2" "62.4" "67.4" "72.9" "59.3" "74.4" "78.2" "66.4" "71.4" "" "" "" "" "" "" "" "" "" "" "55.4" "52.4" "54.5" "50.4" "60.8" "54.5" "62.9" "64.6" "60.9" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4873150472968897924" "False" "Medium" "IsMasterProtein" "Q68DE3" "Basic helix-loop-helix domain-containing protein USF3 OS=Homo sapiens OX=9606 GN=USF3 PE=1 SV=4" "0.027" "False" "1.602" "0" "1" "2" "1" "2245" "241.5" "7.61" "5.53" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00010" "205717" "ENSG00000176542" "USF3" "hsa:205717; Q68DE3; Q7Z3L9; Q8IVF3; Q9H8T4" "" "" "0" "0" "1.022" "0.913" "1.216" "0.936" "1.055" "1.055" "0.989" "0.836" "0.494" "223.2" "228.2" "203.7" "271.5" "208.9" "235.6" "235.6" "220.8" "186.6" "110.3" "" "" "" "" "" "" "" "" "" "" "197.9" "189.0" "177.7" "203.1" "174.2" "216.4" "199.1" "182.5" "171.2" "110.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7907598035424598307" "False" "Medium" "IsMasterProtein" "Q86SH2" "Zygote arrest protein 1 OS=Homo sapiens OX=9606 GN=ZAR1 PE=1 SV=1" "0.027" "False" "1.597" "3" "1" "1" "1" "424" "45.8" "9.06" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13695" "326340" "ENSG00000182223" "ZAR1" "hsa:326340; Q86SH2" "" "Pre-implantation embryo" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2882906632265539377" "False" "Medium" "IsMasterProtein" "Q9NQV6" "PR domain zinc finger protein 10 OS=Homo sapiens OX=9606 GN=PRDM10 PE=1 SV=3" "0.027" "False" "1.597" "1" "1" "1" "1" "1147" "130.1" "6.74" "2.73" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf21549" "56980" "ENSG00000170325" "PRDM10" "B7ZL71; G3XAE5; hsa:56980; J3KP23; Q17R90; Q2KHR4; Q863Z2; Q9NQV6; Q9NXI4; Q9ULI9" "" "" "0" "0" "0.806" "0.894" "0.820" "0.764" "0.982" "0.787" "0.668" "0.721" "2.911" "117.5" "94.7" "105.0" "96.4" "89.7" "115.3" "92.5" "78.5" "84.7" "342.0" "" "" "" "" "" "" "" "" "" "" "104.2" "78.4" "91.6" "72.1" "74.8" "105.9" "78.2" "64.9" "77.7" "342.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887572586952269824" "False" "Medium" "IsMasterProtein" "Q9HCE1" "Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2" "0.027" "False" "1.589" "1" "1" "1" "1" "1003" "113.6" "8.82" "2.46" "1" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf21632, Pf21633, Pf21634, Pf21635" "4343" "ENSG00000155363" "MOV10" "hsa:4343; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9; Q9HCE1" "MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "VEGFA-VEGFR2 signaling" "19" "0" "1.887" "1.009" "1.151" "1.597" "1.036" "1.301" "1.065" "0.823" "0.658" "61.5" "116.1" "62.1" "70.8" "98.3" "63.8" "80.1" "65.6" "50.6" "40.5" "" "" "" "" "" "" "" "" "" "" "54.6" "96.2" "54.2" "53.0" "82.0" "58.6" "67.7" "54.2" "46.4" "40.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-675276312923681114" "False" "Medium" "IsMasterProtein" "Q96GY0" "Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2" "0.027" "False" "1.589" "4" "1" "1" "1" "325" "35.1" "9.82" "1.61" "1" "" "" "other molecular function" "Pf13913" "51101" "ENSG00000104427" "ZC2HC1A" "hsa:51101; Q96GY0; Q9Y372" "" "" "0" "0" "1.102" "1.044" "0.938" "0.861" "1.076" "1.090" "0.936" "0.930" "0.578" "185.0" "203.8" "193.2" "173.4" "159.3" "199.1" "201.6" "173.2" "172.0" "106.9" "" "" "" "" "" "" "" "" "" "" "164.0" "168.8" "168.6" "129.7" "132.8" "182.9" "170.4" "143.2" "157.7" "106.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292330841191308535" "False" "Medium" "IsMasterProtein" "O75420" "GRB10-interacting GYF protein 1 OS=Homo sapiens OX=9606 GN=GIGYF1 PE=1 SV=2" "0.027" "False" "1.588" "1" "1" "1" "1" "1035" "114.5" "5.39" "2.78" "1" "signal transduction" "cytosol;other cell component" "" "Pf02213" "" "ENSG00000146830" "GIGYF1" "O75420; Q6Y7W7; Q8WZ38" "" "" "0" "0" "0.803" "0.714" "0.793" "0.623" "0.877" "0.737" "0.733" "0.814" "2.180" "57.5" "46.2" "41.0" "45.6" "35.8" "50.4" "42.4" "42.1" "46.8" "125.3" "" "" "" "" "" "" "" "" "" "" "51.0" "38.2" "35.8" "34.1" "29.9" "46.3" "35.8" "34.8" "42.9" "125.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "975023732252916358" "False" "Medium" "IsMasterProtein" "P42081" "T-lymphocyte activation antigen CD86 OS=Homo sapiens OX=9606 GN=CD86 PE=1 SV=2" "0.028" "False" "1.583" "2" "1" "1" "1" "329" "37.7" "6.92" "2.31" "1" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton" "signal transduction activity or receptor binding;other molecular function" "Pf07686" "942" "ENSG00000114013" "CD86" "A0N0P0; B7Z2F3; B7Z702; E7ETN5; E9PC27; hsa:942; P42081; Q13655; Q6FHB1; Q6GTS4; Q7M4L5" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; CD28 dependent PI3K/Akt signaling; Interleukin-10 signaling; CD28 dependent Vav1 pathway; CTLA4 inhibitory signaling" "Allograft rejection; IL-3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Macrophage markers; Control of immune tolerance by vasoactive intestinal peptide; Inflammatory response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Cancer immunotherapy by CTLA4 blockade; Cell interactions of the pancreatic cancer microenvironment; Toll-like receptor signaling pathway" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8069107240958525203" "False" "Medium" "IsMasterProtein" "Q92993" "Histone acetyltransferase KAT5 OS=Homo sapiens OX=9606 GN=KAT5 PE=1 SV=2" "0.028" "False" "1.576" "2" "1" "1" "1" "513" "58.5" "8.48" "2.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "10524" "ENSG00000172977" "KAT5" "B4E3C7; C9JL99; hsa:10524; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q92993; Q9BWK7" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Estrogen-dependent gene expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Cardiogenesis; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks" "Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; HDAC6 interactions in the central nervous system" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-680888740988147188" "False" "Medium" "IsMasterProtein" "Q8NBN3" "Transmembrane protein 87A OS=Homo sapiens OX=9606 GN=TMEM87A PE=1 SV=3" "0.028" "False" "1.576" "1" "1" "1" "1" "555" "63.4" "6.74" "2.18" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "" "Pf06814" "25963" "ENSG00000103978" "TMEM87A" "hsa:25963; Q6NT77; Q8NBN3; Q8NCA4; Q9BS46; Q9P103; Q9Y3Y7" "RHOA GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8729887503014056140" "False" "Medium" "IsMasterProtein" "Q8NHY5" "Checkpoint protein HUS1B OS=Homo sapiens OX=9606 GN=HUS1B PE=1 SV=2" "0.028" "False" "1.575" "3" "1" "1" "1" "278" "31.0" "9.33" "2.94" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction" "nucleus;other cell component" "" "Pf04005" "135458" "ENSG00000188996" "HUS1B" "hsa:135458; Q5T4Z2; Q8NHY5" "" "miRNA regulation of DNA damage response; DNA damage response" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-930253281495513943" "False" "Medium" "IsMasterProtein" "Q9HC29" "Nucleotide-binding oligomerization domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NOD2 PE=1 SV=1" "0.028" "False" "1.574" "1" "1" "1" "1" "1040" "115.2" "6.76" "1.73" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00619, Pf05729, Pf13516, Pf17776, Pf17779" "64127" "ENSG00000167207" "NOD2" "E2JEQ6; hsa:64127; Q96RH5; Q96RH6; Q96RH8; Q9HC29" "TAK1-dependent IKK and NF-kappa-B activation ; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "Nucleotide-binding oligomerization domain (NOD) pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Burn wound healing; Ulcerative colitis signaling; Inflammatory bowel disease signaling" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2581467340376562389" "False" "Medium" "IsMasterProtein" "Q68DQ2" "Very large A-kinase anchor protein OS=Homo sapiens OX=9606 GN=CRYBG3 PE=1 SV=3" "0.028" "False" "1.573" "0" "1" "1" "1" "2970" "330.4" "5.20" "2.83" "1" "developmental processes;other biological processes" "other cell component" "other molecular function" "Pf00030, Pf00652" "131544" "ENSG00000080200" "CRYBG3" "B4DLE8; F6VHI2; hsa:131544; Q4G0V8; Q68DQ2; Q7Z4R9; Q86VD0; Q8N262; Q8N7F1; Q8NDQ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-419593273491942870" "False" "Medium" "IsMasterProtein" "P0C7P3" "Protein SLFN14 OS=Homo sapiens OX=9606 GN=SLFN14 PE=1 SV=2" "0.028" "False" "1.573" "1" "1" "2" "1" "912" "103.8" "8.24" "4.85" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04326, Pf17057, Pf21026" "342618" "ENSG00000236320" "SLFN14" "B2RTW9; hsa:342618; P0C7P3" "" "17q12 copy number variation syndrome" "1" "0" "1.112" "1.096" "1.186" "1.141" "1.027" "1.054" "1.002" "0.894" "0.466" "318.3" "354.1" "348.8" "377.6" "363.0" "326.9" "335.3" "319.0" "284.6" "148.4" "" "" "" "" "" "" "" "" "" "" "282.2" "293.3" "304.3" "282.4" "302.7" "300.3" "283.4" "263.7" "261.0" "148.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "729714306402912246" "False" "Medium" "IsMasterProtein" "Q15628" "Tumor necrosis factor receptor type 1-associated DEATH domain protein OS=Homo sapiens OX=9606 GN=TRADD PE=1 SV=2" "0.028" "False" "1.565" "2" "1" "1" "1" "312" "34.2" "6.27" "2.26" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf09034" "8717" "ENSG00000102871" "TRADD" "B2RDS3; B3KQZ9; hsa:8717; Q15628; Q52NZ1" "Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis" "TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5456206388273003181" "False" "Medium" "IsMasterProtein" "O95985" "DNA topoisomerase 3-beta-1 OS=Homo sapiens OX=9606 GN=TOP3B PE=1 SV=1" "0.028" "False" "1.560" "1" "1" "1" "1" "862" "96.6" "8.12" "2.92" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01751" "8940" "ENSG00000100038" "TOP3B" "A0M8Q3; hsa:8940; O95985; Q9BUP5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2959311852295820305" "False" "Medium" "IsMasterProtein" "Q6TFL3" "Coiled-coil domain-containing protein 171 OS=Homo sapiens OX=9606 GN=CCDC171 PE=1 SV=1" "0.028" "False" "1.559" "1" "1" "2" "1" "1326" "152.7" "6.81" "2.05" "1" "" "" "" "" "203238" "ENSG00000164989" "CCDC171" "B7ZM22; Q5SU58; Q6P1W1; Q6TFL3; Q6ZR13; Q8N1Z4; Q8N8L3; Q8TBR2" "" "" "0" "0" "0.970" "0.965" "0.951" "1.173" "0.888" "1.110" "0.963" "0.925" "0.768" "90.3" "87.6" "87.1" "85.8" "105.9" "80.2" "100.2" "86.9" "83.5" "69.4" "" "" "" "" "" "" "" "" "" "" "80.0" "72.6" "76.0" "64.2" "88.3" "73.6" "84.7" "71.8" "76.6" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1654139714091192156" "False" "Medium" "IsMasterProtein" "P56181" "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV3 PE=1 SV=2" "0.028" "False" "1.557" "7" "1" "1" "1" "108" "11.9" "9.70" "2.33" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf15880" "4731" "ENSG00000160194" "NDUFV3" "A8K0M1; hsa:4731; J3KNX7; P56181; Q6FGD3; Q8WU60; Q9HCR5" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "1.073" "1.079" "1.047" "1.122" "1.148" "1.071" "1.185" "1.147" "0.427" "92.1" "98.9" "99.5" "96.5" "103.4" "105.8" "98.7" "109.2" "105.7" "39.3" "" "" "" "" "" "" "" "" "" "" "81.7" "81.9" "86.8" "72.2" "86.2" "97.2" "83.4" "90.3" "96.9" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "Medium" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.029" "False" "1.543" "1" "1" "1" "1" "593" "66.4" "6.55" "0.00" "1" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Platelet degranulation ; Other interleukin signaling" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134290291908392931" "False" "Medium" "IsMasterProtein" "Q8N5G2" "Macoilin OS=Homo sapiens OX=9606 GN=MACO1 PE=1 SV=1" "0.029" "False" "1.542" "1" "1" "1" "1" "664" "76.1" "9.07" "2.38" "1" "developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf09726" "55219" "ENSG00000204178" "MACO1" "B1AK00; hsa:55219; Q2TLX5; Q2TLX6; Q8N5G2; Q9NVG6" "RHOC GTPase cycle; RHOA GTPase cycle" "" "2" "0" "0.854" "0.917" "0.828" "0.845" "0.885" "0.766" "0.916" "0.913" "0.724" "202.3" "172.8" "185.4" "167.5" "171.0" "179.0" "155.0" "185.2" "184.6" "146.4" "" "" "" "" "" "" "" "" "" "" "179.4" "143.1" "161.8" "125.3" "142.6" "164.4" "131.0" "153.1" "169.3" "146.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "168028196310307257" "False" "Medium" "IsMasterProtein" "Q13823" "Nucleolar GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=GNL2 PE=1 SV=1" "0.030" "False" "1.542" "1" "1" "1" "1" "731" "83.6" "9.25" "0.00" "1" "other biological processes" "nucleus" "other molecular function" "Pf01926, Pf08153" "29889" "ENSG00000134697" "GNL2" "hsa:29889; Q13823; Q9BWN7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1345191434985933779" "False" "Medium" "IsMasterProtein" "Q9UF56" "F-box/LRR-repeat protein 17 OS=Homo sapiens OX=9606 GN=FBXL17 PE=1 SV=3" "0.030" "False" "1.536" "2" "1" "1" "1" "701" "75.6" "8.07" "0.00" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12937, Pf13516" "64839" "ENSG00000145743" "FBXL17" "A1A4E3; hsa:64839; Q9UF56" "Regulation of BACH1 activity" "Hedgehog signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479152358026622907" "False" "Medium" "IsMasterProtein" "Q8WV74" "Mitochondrial coenzyme A diphosphatase NUDT8 OS=Homo sapiens OX=9606 GN=NUDT8 PE=1 SV=2" "0.030" "False" "1.534" "3" "1" "1" "1" "236" "25.4" "8.41" "2.74" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00293" "254552" "ENSG00000167799" "NUDT8" "hsa:254552; Q6ZW59; Q8WV74" "Vitamin B5 (pantothenate) metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2593700082527683985" "False" "Medium" "IsMasterProtein" "O43572" "A-kinase anchor protein 10, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP10 PE=1 SV=2" "0.030" "False" "1.525" "1" "1" "1" "1" "662" "73.8" "6.39" "3.33" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00615" "11216" "ENSG00000108599" "AKAP10" "B2R650; hsa:11216; O43572; Q96AJ7" "Factors involved in megakaryocyte development and platelet production" "G protein signaling pathways; TAR syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7923817397987579375" "False" "Medium" "IsMasterProtein" "P04198" "N-myc proto-oncogene protein OS=Homo sapiens OX=9606 GN=MYCN PE=1 SV=2" "0.030" "False" "1.523" "2" "1" "1" "1" "464" "49.5" "5.66" "2.57" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf01056" "4613" "ENSG00000134323" "MYCN" "hsa:4613; P04198; Q53XS5; Q6LDT9" "Signaling by ALK" "Pathways affected in adenoid cystic carcinoma; Development of ureteric collection system; GDNF signaling" "4" "0" "0.795" "0.982" "0.837" "0.958" "0.912" "0.905" "0.805" "0.834" "0.749" "297.9" "236.9" "292.6" "249.2" "285.4" "271.7" "269.6" "239.8" "248.5" "223.1" "" "" "" "" "" "" "" "" "" "" "264.2" "196.2" "255.3" "186.4" "237.9" "249.5" "227.9" "198.2" "227.9" "223.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927192011377040522" "False" "Medium" "IsMasterProtein" "Q2NL68" "Proline and serine-rich protein 3 OS=Homo sapiens OX=9606 GN=PROSER3 PE=1 SV=1" "0.031" "False" "1.520" "2" "1" "1" "1" "480" "51.0" "7.14" "2.34" "1" "" "cytoskeleton;other cell component" "" "" "148137" "ENSG00000167595" "PROSER3" "hsa:148137; Q2NL68; Q8NDI3; Q8WWC8; Q96NL4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020441092987520454" "False" "Medium" "IsMasterProtein" "P53355" "Death-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=DAPK1 PE=1 SV=6" "0.031" "False" "1.518" "1" "1" "2" "1" "1430" "159.9" "6.83" "6.23" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00023, Pf00069, Pf00531" "1612" "ENSG00000196730" "DAPK1" "B7ZLD2; B7ZLE7; hsa:1612; P53355; Q14CQ7; Q1W5W0; Q68CP8; Q6ZRZ3; Q9BTL8" "Caspase activation via Dependence Receptors in the absence of ligand" "Bladder cancer; Netrin-UNC5B signaling pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5476878865190536687" "False" "Medium" "IsMasterProtein" "Q14693" "Phosphatidate phosphatase LPIN1 OS=Homo sapiens OX=9606 GN=LPIN1 PE=1 SV=2" "0.031" "False" "1.517" "1" "1" "1" "1" "890" "98.6" "6.58" "2.80" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf04571, Pf08235, Pf16876" "23175" "ENSG00000134324" "LPIN1" "A8MU38; B4DET9; B4DGS4; B4DGZ6; B5MC18; B7Z858; D6W506; E7ESE7; F5GY24; hsa:23175; Q14693; Q53T25" "Triglyceride biosynthesis; Depolymerization of the Nuclear Lamina; Synthesis of PC; Synthesis of PE" "Sterol regulatory element-binding proteins (SREBP) signaling; Adipogenesis; Transcription factor regulation in adipogenesis; Congenital generalized lipodystrophy" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8073063858640932961" "False" "Medium" "IsMasterProtein" "Q96BZ9" "TBC1 domain family member 20 OS=Homo sapiens OX=9606 GN=TBC1D20 PE=1 SV=1" "0.031" "False" "1.515" "2" "1" "1" "1" "403" "45.8" "6.86" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus" "enzyme regulator activity;other molecular function" "Pf00566" "128637" "ENSG00000125875" "TBC1D20" "A8K6I3; B9A6M1; hsa:128637; Q5JWQ7; Q6ZSY8; Q96BZ9; Q96NE1; Q9BYM7; Q9H140" "COPII-mediated vesicle transport; TBC/RABGAPs" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4008983294682530798" "False" "Medium" "IsMasterProtein" "Q9UBZ4" "DNA-(apurinic or apyrimidinic site) endonuclease 2 OS=Homo sapiens OX=9606 GN=APEX2 PE=1 SV=1" "0.031" "False" "1.512" "3" "1" "1" "1" "518" "57.4" "8.29" "2.63" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf06839" "27301" "ENSG00000169188" "APEX2" "hsa:27301; Q9UBZ4; Q9Y5X7" "" "Base excision repair; DNA repair pathways, full network" "2" "0" "1.333" "0.972" "0.527" "0.609" "0.950" "0.626" "0.741" "0.819" "5.127" "14.7" "19.6" "14.3" "7.7" "8.9" "14.0" "9.2" "10.9" "12.0" "75.3" "" "" "" "" "" "" "" "" "" "" "13.0" "16.2" "12.5" "5.8" "7.5" "12.8" "7.8" "9.0" "11.0" "75.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-939904416920954895" "False" "Medium" "IsMasterProtein" "O95271" "Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=2" "0.031" "False" "1.510" "1" "1" "1" "1" "1327" "142.0" "7.05" "0.00" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00023, Pf00644, Pf07647, Pf13637, Pf13857" "8658" "ENSG00000173273; ENSG00000285372" "TNKS" "hsa:8658; O95271; O95272; Q4G0F2; Q59FX0" "Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN" "NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds; 8p23.1 copy number variation syndrome" "8" "0" "1.016" "1.648" "0.984" "1.327" "1.234" "1.646" "1.752" "1.351" "0.751" "46.3" "47.0" "76.2" "45.5" "61.4" "57.1" "76.2" "81.0" "62.5" "34.7" "" "" "" "" "" "" "" "" "" "" "41.0" "38.9" "66.5" "34.1" "51.2" "52.4" "64.4" "67.0" "57.3" "34.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8810939646490420813" "False" "Medium" "IsMasterProtein" "P0C646" "Olfactory receptor 52Z1P OS=Homo sapiens OX=9606 GN=OR52Z1P PE=3 SV=2" "0.032" "False" "1.509" "3" "1" "1" "1" "298" "33.4" "8.65" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "" "" "OR52Z1P" "A0A087X1Z4; P0C646" "Expression and translocation of olfactory receptors" "" "1" "0" "1.029" "0.848" "0.974" "0.768" "0.945" "0.876" "0.946" "1.148" "0.538" "31.2" "32.1" "26.5" "30.4" "24.0" "29.5" "27.3" "29.5" "35.8" "16.8" "" "" "" "" "" "" "" "" "" "" "27.7" "26.6" "23.1" "22.7" "20.0" "27.1" "23.1" "24.4" "32.9" "16.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1413134168628784763" "False" "Medium" "IsMasterProtein" "Q9Y2Q0" "Phospholipid-transporting ATPase IA OS=Homo sapiens OX=9606 GN=ATP8A1 PE=1 SV=1" "0.032" "False" "1.503" "1" "1" "1" "1" "1164" "131.3" "6.84" "3.03" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf13246, Pf16209, Pf16212" "10396" "ENSG00000124406" "ATP8A1" "hsa:10396; Q32M35; Q32M36; Q4W5J7; Q4W5P2; Q9Y2Q0" "Neutrophil degranulation; Ion transport by P-type ATPases" "Peptide GPCRs" "3" "0" "0.881" "0.839" "0.870" "0.849" "0.855" "0.879" "0.861" "0.853" "0.583" "208.1" "183.3" "174.6" "181.0" "176.8" "178.0" "183.0" "179.2" "177.6" "121.3" "" "" "" "" "" "" "" "" "" "" "184.5" "151.9" "152.4" "135.4" "147.4" "163.5" "154.7" "148.1" "162.9" "121.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190798800217515771" "False" "Medium" "IsMasterProtein" "Q09428" "ATP-binding cassette sub-family C member 8 OS=Homo sapiens OX=9606 GN=ABCC8 PE=1 SV=6" "0.032" "False" "1.502" "0" "1" "1" "1" "1581" "176.9" "7.81" "2.38" "1" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00005, Pf00664" "6833" "ENSG00000006071" "ABCC8" "A6NMX8; E3UYX6; hsa:6833; O75948; Q09428; Q16583" "Regulation of insulin secretion; ATP sensitive Potassium channels; Defective ABCC8 can cause hypo- and hyper-glycemias" "" "3" "0" "1.003" "0.802" "1.066" "1.092" "1.057" "1.149" "1.140" "0.994" "0.482" "82.6" "82.8" "66.3" "88.1" "90.2" "87.3" "94.9" "94.1" "82.1" "39.8" "" "" "" "" "" "" "" "" "" "" "73.3" "68.6" "57.8" "65.9" "75.2" "80.2" "80.2" "77.8" "75.3" "39.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7034970075323541654" "False" "Medium" "IsMasterProtein" "Q86WW8" "Cytochrome c oxidase assembly factor 5 OS=Homo sapiens OX=9606 GN=COA5 PE=1 SV=1" "0.032" "False" "1.501" "9" "1" "1" "1" "74" "8.4" "8.68" "3.37" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf10203" "493753" "ENSG00000183513" "COA5" "hsa:493753; Q86WW8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3433640021068087634" "False" "Medium" "IsMasterProtein" "Q8N1G0" "Zinc finger protein 687 OS=Homo sapiens OX=9606 GN=ZNF687 PE=1 SV=1" "0.032" "False" "1.500" "1" "1" "1" "1" "1237" "129.4" "8.19" "2.82" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf16622" "57592" "ENSG00000143373" "ZNF687" "D3DV17; hsa:57592; Q68DQ8; Q8N1G0; Q9H937; Q9P2A7" "" "" "0" "0" "0.859" "0.885" "1.016" "0.820" "1.031" "1.013" "1.071" "0.923" "0.560" "112.4" "96.5" "99.4" "114.1" "92.1" "115.9" "113.8" "120.3" "103.7" "62.9" "" "" "" "" "" "" "" "" "" "" "99.6" "79.9" "86.8" "85.4" "76.8" "106.5" "96.2" "99.4" "95.1" "62.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925362542189153162" "False" "Medium" "IsMasterProtein" "Q92854" "Semaphorin-4D OS=Homo sapiens OX=9606 GN=SEMA4D PE=1 SV=1" "0.032" "False" "1.499" "1" "1" "1" "1" "862" "96.1" "7.96" "2.76" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf01403, Pf01437" "10507" "ENSG00000187764" "SEMA4D" "B2RPM6; hsa:10507; Q7Z5S4; Q8N8B0; Q92854" "Sema4D induced cell migration and growth-cone collapse; Sema4D mediated inhibition of cell attachment and migration; Other semaphorin interactions" "Clock-controlled autophagy in bone metabolism" "4" "0" "1.210" "1.225" "1.508" "1.003" "1.173" "0.856" "1.139" "0.859" "0.532" "27.9" "33.8" "34.2" "42.1" "28.0" "32.7" "23.9" "31.8" "24.0" "14.8" "" "" "" "" "" "" "" "" "" "" "24.8" "28.0" "29.8" "31.5" "23.4" "30.1" "20.2" "26.3" "22.0" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909232235632679983" "False" "Medium" "IsMasterProtein" "Q13418" "Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2" "0.033" "False" "1.489" "2" "1" "1" "1" "452" "51.4" "8.07" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "3611" "ENSG00000166333" "ILK" "B7Z1I0; B7Z418; D3DQU0; hsa:3611; P57043; Q13418; Q68DZ3" "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system; 2q37 copy number variation syndrome" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036178333900895591" "False" "Medium" "IsMasterProtein" "Q5EBL8" "PDZ domain-containing protein 11 OS=Homo sapiens OX=9606 GN=PDZD11 PE=1 SV=2" "0.033" "False" "1.482" "6" "1" "1" "1" "140" "16.1" "7.21" "2.86" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf00595" "51248" "ENSG00000120509" "PDZD11" "D3DVU3; hsa:51248; Q5EBL8; Q6UWE1; Q9P0Q1" "Ion transport by P-type ATPases; Ion influx/efflux at host-pathogen interface; Transport of vitamins, nucleosides, and related molecules; Biotin transport and metabolism; Vitamin B5 (pantothenate) metabolism" "" "5" "0" "0.930" "0.605" "0.818" "0.629" "0.504" "0.715" "0.597" "0.585" "0.490" "520.7" "484.3" "315.2" "425.9" "327.6" "262.2" "372.5" "310.7" "304.7" "255.3" "" "" "" "" "" "" "" "" "" "" "461.7" "401.2" "275.1" "318.5" "273.2" "240.9" "314.8" "256.8" "279.5" "255.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8360572772307666669" "False" "Medium" "IsMasterProtein" "O75095" "Multiple epidermal growth factor-like domains protein 6 OS=Homo sapiens OX=9606 GN=MEGF6 PE=1 SV=4" "0.034" "False" "1.480" "1" "1" "1" "1" "1541" "161.1" "6.38" "2.54" "1" "" "non-structural extracellular" "other molecular function" "Pf00053, Pf07645, Pf12662, Pf14670" "1953" "ENSG00000162591" "MEGF6" "hsa:1953; O75095; Q4AC86; Q5VV39" "" "" "0" "0" "1.617" "1.092" "1.295" "1.335" "1.204" "1.361" "1.302" "1.038" "0.935" "17.6" "28.5" "19.2" "22.8" "23.5" "21.2" "24.0" "22.9" "18.3" "16.5" "" "" "" "" "" "" "" "" "" "" "15.6" "23.6" "16.8" "17.1" "19.6" "19.5" "20.3" "19.0" "16.8" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2722667735579585141" "False" "Medium" "IsMasterProtein" "Q9BWK5" "Cell cycle regulator of non-homologous end joining OS=Homo sapiens OX=9606 GN=CYREN PE=1 SV=2" "0.034" "False" "1.478" "6" "1" "1" "1" "157" "16.8" "5.19" "2.85" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf15325" "78996" "ENSG00000122783" "CYREN" "A0A024R780; A0A087WWQ8; hsa:78996; Q6NWZ4; Q6ZNR5; Q9BWK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7812634382890342947" "False" "Medium" "IsMasterProtein" "Q7Z5P9" "Mucin-19 OS=Homo sapiens OX=9606 GN=MUC19 PE=1 SV=3" "0.034" "False" "1.475" "0" "1" "1" "1" "8384" "804.8" "5.01" "0.00" "1" "" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi" "" "Pf00094, Pf01826, Pf08742" "283463" "" "MUC19" "G3CIG0; hsa:283463; Q7Z5P9; Q8NA85" "Dectin-2 family; Termination of O-glycan biosynthesis; Defective GALNT3 causes HFTC; Defective C1GALT1C1 causes TNPS; Defective GALNT12 causes CRCS1" "" "6" "0" "1.270" "1.250" "1.149" "1.049" "0.905" "1.404" "1.197" "0.892" "0.821" "89.4" "113.5" "111.7" "102.7" "93.8" "80.9" "125.5" "107.0" "79.8" "73.4" "" "" "" "" "" "" "" "" "" "" "79.3" "94.0" "97.5" "76.8" "78.2" "74.3" "106.1" "88.4" "73.2" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8098338321965318557" "False" "Medium" "IsMasterProtein" "Q6UW78" "Ubiquinol-cytochrome-c reductase complex assembly factor 3 OS=Homo sapiens OX=9606 GN=UQCC3 PE=1 SV=2" "0.034" "False" "1.475" "9" "1" "1" "1" "93" "10.1" "9.41" "2.80" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf15141" "790955" "ENSG00000204922" "UQCC3" "hsa:790955; Q5FVD5; Q6UW78" "" "Mitochondrial complex III assembly" "1" "0" "1.014" "0.885" "1.061" "1.045" "0.961" "1.052" "0.866" "1.016" "0.817" "131.0" "132.8" "115.9" "139.0" "136.8" "125.9" "137.8" "113.4" "133.0" "107.0" "" "" "" "" "" "" "" "" "" "" "116.1" "110.0" "101.1" "103.9" "114.1" "115.6" "116.4" "93.7" "122.0" "107.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814263042183265605" "False" "Medium" "IsMasterProtein" "Q5VWT5" "FYN-binding protein 2 OS=Homo sapiens OX=9606 GN=FYB2 PE=1 SV=1" "0.034" "False" "1.473" "1" "1" "1" "1" "728" "82.0" "8.38" "2.19" "1" "cell adhesion;signal transduction;other biological processes" "plasma membrane;other membranes" "" "Pf14603" "199920" "ENSG00000187889" "FYB2" "hsa:199920; Q5VWT5; Q63HM3; Q6ZUY6" "" "" "0" "0" "0.982" "0.868" "0.805" "0.809" "0.994" "0.934" "0.893" "0.939" "0.814" "258.5" "253.9" "224.4" "208.1" "209.2" "257.0" "241.5" "230.8" "242.8" "210.4" "" "" "" "" "" "" "" "" "" "" "229.3" "210.3" "195.8" "155.6" "174.4" "236.1" "204.1" "190.8" "222.7" "210.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7864546337291750695" "False" "Medium" "IsMasterProtein" "Q5TIA1" "Meiosis inhibitor protein 1 OS=Homo sapiens OX=9606 GN=MEI1 PE=1 SV=2" "0.035" "False" "1.467" "0" "1" "1" "1" "1274" "141.1" "6.70" "2.15" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "" "" "" "150365" "ENSG00000167077" "MEI1" "B7Z745; hsa:150365; Q1XAP1; Q1XAP2; Q5TIA1; Q8IYJ5; Q8N5K5; Q8N9H3; Q8TC68" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481349692904655230" "False" "Medium" "IsMasterProtein" "Q9UPY5" "Cystine/glutamate transporter OS=Homo sapiens OX=9606 GN=SLC7A11 PE=1 SV=1" "0.035" "False" "1.466" "1" "1" "1" "1" "501" "55.4" "9.19" "2.26" "1" "cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf13520" "23657" "ENSG00000151012" "SLC7A11" "A8K2U4; hsa:23657; Q9UPY5" "NFE2L2 regulating anti-oxidant/detoxification enzymes; Basigin interactions; Amino acid transport across the plasma membrane" "Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; NRF2-ARE regulation; p53 transcriptional gene network; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Amino acid metabolism in triple-negative breast cancer cells" "12" "0" "0.974" "0.948" "0.917" "0.960" "1.056" "0.977" "0.794" "1.122" "0.990" "156.3" "152.2" "148.1" "143.2" "149.9" "165.0" "152.7" "124.1" "175.3" "154.7" "" "" "" "" "" "" "" "" "" "" "138.6" "126.1" "129.3" "107.1" "125.0" "151.6" "129.0" "102.6" "160.8" "154.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630753652904307190" "False" "Medium" "IsMasterProtein" "A0A1B0GVM6" "Uncharacterized protein C11orf97 OS=Homo sapiens OX=9606 GN=C11orf97 PE=3 SV=1" "0.035" "False" "1.464" "6" "1" "1" "1" "126" "13.9" "9.35" "2.61" "1" "" "cytoskeleton;other cell component" "" "" "643037" "ENSG00000257057" "C11orf97" "A0A1B0GVM6; hsa:643037" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-511612548329445483" "False" "Medium" "IsMasterProtein" "P32970" "CD70 antigen OS=Homo sapiens OX=9606 GN=CD70 PE=1 SV=2" "0.035" "False" "1.462" "7" "1" "1" "1" "193" "21.1" "8.53" "2.09" "1" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf00229" "970" "ENSG00000125726" "CD70" "B4DPR8; hsa:970; P32970; Q53XX4; Q96J57" "TNFs bind their physiological receptors" "" "1" "0" "1.411" "1.269" "1.313" "1.642" "1.361" "1.197" "1.125" "1.453" "0.966" "31.0" "43.8" "39.4" "40.7" "50.9" "42.2" "37.1" "34.9" "45.1" "30.0" "" "" "" "" "" "" "" "" "" "" "27.5" "36.3" "34.4" "30.5" "42.5" "38.8" "31.4" "28.9" "41.3" "30.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2256509221484731544" "False" "Medium" "IsMasterProtein" "Q8NE18" "Putative methyltransferase NSUN7 OS=Homo sapiens OX=9606 GN=NSUN7 PE=1 SV=4" "0.035" "False" "1.462" "1" "1" "1" "1" "718" "81.0" "8.75" "2.39" "1" "other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf01189, Pf21148" "79730" "ENSG00000179299" "NSUN7" "C9JI19; hsa:79730; Q8N9K8; Q8NE18; Q9H815" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8329057920573991026" "False" "Medium" "IsMasterProtein" "O75764" "Transcription elongation factor A protein 3 OS=Homo sapiens OX=9606 GN=TCEA3 PE=1 SV=2" "0.036" "False" "1.459" "3" "1" "1" "1" "348" "38.9" "9.19" "2.25" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6920" "ENSG00000204219; ENSG00000282941" "TCEA3" "A8K2K7; hsa:6920; O75764; Q5DR83" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2826650301699758635" "False" "Medium" "IsMasterProtein" "Q9HCU5" "Guanine nucleotide-exchange factor SEC12 OS=Homo sapiens OX=9606 GN=PREB PE=1 SV=2" "0.036" "False" "1.458" "5" "1" "2" "1" "417" "45.4" "7.88" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400" "10113" "ENSG00000138073" "PREB" "hsa:10113; Q53SZ8; Q9HCU5; Q9UH94" "COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER" "" "3" "0" "1.123" "1.134" "1.257" "1.187" "1.106" "1.396" "0.987" "1.171" "0.789" "57.5" "64.6" "65.2" "72.3" "68.3" "63.6" "80.3" "56.8" "67.4" "45.4" "" "" "" "" "" "" "" "" "" "" "51.0" "53.5" "56.9" "54.1" "56.9" "58.4" "67.9" "46.9" "61.8" "45.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100203530818565223" "False" "Medium" "IsMasterProtein" "O00443" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2" "0.036" "False" "1.454" "0" "1" "1" "1" "1686" "190.6" "8.02" "3.03" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5286" "ENSG00000011405" "PIK3C2A" "B0LPH2; B4E2G4; hsa:5286; O00443; Q14CQ9" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "14" "0" "0.836" "0.953" "1.042" "0.847" "0.835" "0.938" "0.904" "0.941" "2.273" "187.6" "156.9" "178.8" "195.5" "158.9" "156.8" "176.0" "169.6" "176.5" "426.5" "" "" "" "" "" "" "" "" "" "" "166.4" "130.0" "156.0" "146.2" "132.5" "144.0" "148.8" "140.2" "161.9" "426.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627020223265262766" "False" "Medium" "IsMasterProtein" "Q8N0W3" "L-fucose kinase OS=Homo sapiens OX=9606 GN=FCSK PE=1 SV=2" "0.037" "False" "1.447" "1" "1" "1" "1" "1084" "117.5" "6.25" "2.62" "1" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf07959, Pf08544" "197258" "ENSG00000157353" "FCSK" "hsa:197258; Q5PSM3; Q5XKL6; Q6ZRA0; Q8N0W3; Q96MT9" "GDP-fucose biosynthesis" "" "1" "0" "1.075" "0.941" "1.466" "1.102" "0.951" "1.232" "1.031" "0.921" "0.847" "87.4" "94.0" "82.3" "128.1" "96.3" "83.1" "107.7" "90.1" "80.5" "74.0" "" "" "" "" "" "" "" "" "" "" "77.5" "77.8" "71.8" "95.8" "80.3" "76.3" "91.0" "74.5" "73.8" "74.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7937609985281019227" "False" "Medium" "IsMasterProtein" "Q96CM4" "Nucleoredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=NXNL1 PE=1 SV=1" "0.038" "False" "1.432" "4" "1" "1" "1" "212" "23.9" "4.84" "3.04" "1" "other biological processes" "other cell component" "" "Pf13905" "115861" "ENSG00000171773" "NXNL1" "hsa:115861; Q0QD37; Q96CM4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4165561941768478758" "False" "Medium" "IsMasterProtein" "Q9UID6" "Zinc finger protein 639 OS=Homo sapiens OX=9606 GN=ZNF639 PE=1 SV=1" "0.038" "False" "1.421" "1" "1" "1" "1" "485" "56.0" "5.57" "2.09" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "51193" "ENSG00000121864" "ZNF639" "A9X3Z9; D3DNR3; hsa:51193; Q9UID6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4274550233442201584" "False" "Medium" "IsMasterProtein" "Q5TC63" "Growth hormone-regulated TBC protein 1 OS=Homo sapiens OX=9606 GN=GRTP1 PE=1 SV=4" "0.038" "False" "1.414" "2" "1" "1" "1" "336" "38.5" "8.78" "0.00" "1" "" "" "enzyme regulator activity" "Pf00566" "79774" "ENSG00000139835" "GRTP1" "B9A6K2; hsa:79774; Q2M232; Q5TC63; Q5TC64; Q66K26; Q6P659; Q8N528; Q9H695" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4757838979120085140" "False" "Medium" "IsMasterProtein" "P17405" "Sphingomyelin phosphodiesterase OS=Homo sapiens OX=9606 GN=SMPD1 PE=1 SV=5" "0.038" "False" "1.412" "2" "1" "1" "1" "631" "69.9" "7.28" "2.23" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00149, Pf19272" "6609" "ENSG00000166311" "SMPD1" "A8K8M3; E9PKS3; hsa:6609; P17405; P17406; Q13811; Q16837; Q16841" "Glycosphingolipid catabolism" "Ovarian infertility; Sphingolipid metabolism: integrated pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1130505086342919631" "False" "Medium" "IsMasterProtein" "Q99704" "Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1" "0.039" "False" "1.396" "2" "1" "1" "1" "481" "52.4" "6.47" "3.52" "1" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00169, Pf02174" "1796" "ENSG00000115325" "DOK1" "hsa:1796; O43204; Q53TY2; Q99704; Q9UHG6" "RET signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1" "Kit receptor signaling pathway; VEGFA-VEGFR2 signaling; GDNF signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901345748943565030" "False" "Medium" "IsMasterProtein" "Q6P1S2" "Protein C3orf33 OS=Homo sapiens OX=9606 GN=C3orf33 PE=1 SV=2" "0.040" "False" "1.393" "2" "1" "1" "1" "294" "33.7" "9.85" "2.32" "1" "other biological processes" "non-structural extracellular;other membranes" "" "" "285315" "ENSG00000174928" "C3orf33" "A8K1H5; hsa:285315; Q6P1S2; Q86YE6; Q8IXA7; Q96NB5" "" "" "0" "0" "0.982" "1.023" "0.946" "1.068" "1.097" "0.975" "1.025" "0.943" "0.370" "267.4" "262.7" "273.5" "253.1" "285.6" "293.3" "260.6" "274.2" "252.3" "98.9" "" "" "" "" "" "" "" "" "" "" "237.1" "217.6" "238.6" "189.3" "238.1" "269.4" "220.3" "226.7" "231.3" "98.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5320460450768777920" "False" "Medium" "IsMasterProtein" "P11926" "Ornithine decarboxylase OS=Homo sapiens OX=9606 GN=ODC1 PE=1 SV=2" "0.040" "False" "1.393" "2" "1" "2" "1" "461" "51.1" "5.26" "4.98" "1" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00278, Pf02784" "4953" "ENSG00000115758" "ODC1" "hsa:4953; P11926; Q53TU3; Q6LDS9" "Regulation of ornithine decarboxylase (ODC)" "Methionine de novo and salvage pathway; Amino acid metabolism" "4" "0" "0.948" "0.782" "0.870" "0.784" "0.755" "0.706" "0.799" "0.710" "0.926" "850.8" "806.7" "665.3" "740.4" "666.7" "642.6" "600.2" "679.5" "604.3" "787.8" "" "" "" "" "" "" "" "" "" "" "754.5" "668.3" "580.5" "553.7" "555.9" "590.3" "507.3" "561.6" "554.2" "787.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1794724267132355411" "False" "Medium" "IsMasterProtein" "Q9Y258" "C-C motif chemokine 26 OS=Homo sapiens OX=9606 GN=CCL26 PE=1 SV=1" "0.040" "False" "1.391" "6" "1" "1" "1" "94" "10.6" "10.20" "2.36" "1" "cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf00048" "10344" "ENSG00000006606" "CCL26" "A0N0Q5; hsa:10344; Q52LV8; Q9Y258" "" "Chemokine signaling pathway; Overview of proinflammatory and profibrotic mediators" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139292263047059724" "False" "Medium" "IsMasterProtein" "Q96L50" "Leucine-rich repeat protein 1 OS=Homo sapiens OX=9606 GN=LRR1 PE=1 SV=2" "0.040" "False" "1.382" "3" "1" "1" "1" "414" "46.7" "9.09" "2.12" "1" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus" "" "Pf00560, Pf12799" "122769" "ENSG00000165501" "LRR1" "A5D6X3; B4DDE0; hsa:122769; Q52M24; Q86SZ1; Q8N6H9; Q96L50" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5840239989080540215" "False" "Medium" "IsMasterProtein" "Q8IVH2" "Forkhead box protein P4 OS=Homo sapiens OX=9606 GN=FOXP4 PE=1 SV=1" "0.040" "False" "1.380" "2" "1" "1" "1" "680" "73.4" "6.40" "2.22" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16159" "116113" "ENSG00000137166" "FOXP4" "hsa:116113; Q5W098; Q7Z7F8; Q8IVH2; Q8IW55; Q96E19" "" "" "0" "0" "1.242" "1.035" "1.306" "1.041" "0.961" "1.117" "0.947" "1.095" "2.090" "35.1" "43.6" "36.3" "45.9" "36.5" "33.7" "39.2" "33.2" "38.4" "73.4" "" "" "" "" "" "" "" "" "" "" "31.1" "36.1" "31.7" "34.3" "30.5" "31.0" "33.2" "27.5" "35.3" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318863470258606833" "False" "Medium" "IsMasterProtein" "Q8IWE2" "Protein NOXP20 OS=Homo sapiens OX=9606 GN=FAM114A1 PE=1 SV=2" "0.041" "False" "1.377" "1" "1" "1" "1" "563" "60.7" "4.68" "2.14" "1" "" "cytosol;ER/Golgi;nucleus" "" "Pf05334" "92689" "ENSG00000197712" "FAM114A1" "A8K9W6; hsa:92689; Q6MZV4; Q8IWE2; Q9BVL6" "" "" "0" "0" "0.873" "0.776" "0.675" "0.616" "0.522" "0.517" "0.707" "1.013" "0.698" "95.0" "83.0" "73.7" "64.1" "58.5" "49.6" "49.1" "67.2" "96.3" "66.4" "" "" "" "" "" "" "" "" "" "" "84.3" "68.7" "64.3" "48.0" "48.8" "45.5" "41.5" "55.6" "88.3" "66.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2400563382021846974" "False" "Medium" "IsMasterProtein" "Q16281" "Cyclic nucleotide-gated channel alpha-3 OS=Homo sapiens OX=9606 GN=CNGA3 PE=1 SV=2" "0.041" "False" "1.377" "1" "1" "2" "1" "694" "78.8" "7.69" "3.64" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00027, Pf00520, Pf16526" "1261" "ENSG00000144191" "CNGA3" "E9PF93; hsa:1261; Q16281; Q4VAP7; Q53RD2; Q6ZNA7; Q9UP64" "" "NO/cGMP/PKG mediated neuroprotection" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3340438391070150968" "False" "Medium" "IsMasterProtein" "Q5SZD1" "Uncharacterized protein C6orf141 OS=Homo sapiens OX=9606 GN=C6orf141 PE=1 SV=3" "0.041" "False" "1.375" "3" "1" "1" "1" "244" "26.7" "8.54" "2.67" "1" "" "" "" "" "135398" "ENSG00000197261" "C6orf141" "A8K1H4; hsa:135398; Q5SZD1; Q8N400; Q96NQ1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-966877132828482009" "False" "Medium" "IsMasterProtein" "Q96DA6" "Mitochondrial import inner membrane translocase subunit TIM14 OS=Homo sapiens OX=9606 GN=DNAJC19 PE=1 SV=3" "0.041" "False" "1.374" "8" "1" "1" "1" "116" "12.5" "10.10" "2.93" "1" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00226" "131118" "ENSG00000205981" "DNAJC19" "B2R4B1; C9JBV1; hsa:131118; Q96DA6" "Mitochondrial protein import" "" "1" "0" "0.901" "1.153" "0.863" "0.908" "1.049" "0.884" "0.869" "0.984" "0.524" "186.9" "168.4" "215.4" "161.3" "169.8" "196.1" "165.3" "162.5" "184.0" "97.9" "" "" "" "" "" "" "" "" "" "" "165.8" "139.5" "188.0" "120.6" "141.6" "180.1" "139.7" "134.3" "168.8" "97.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414534694854942498" "False" "Medium" "IsMasterProtein" "Q9BY50" "Signal peptidase complex catalytic subunit SEC11C OS=Homo sapiens OX=9606 GN=SEC11C PE=1 SV=3" "0.041" "False" "1.372" "5" "1" "1" "1" "192" "21.5" "9.20" "2.25" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00717" "90701" "ENSG00000166562" "SEC11C" "B2RAA3; hsa:90701; Q9BY50" "SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Maturation of hRSV A proteins; Synthesis, secretion, and deacylation of Ghrelin" "" "5" "0" "0.957" "0.791" "0.912" "0.526" "0.893" "1.054" "0.883" "1.089" "0.925" "24.6" "23.6" "19.5" "22.5" "13.0" "22.0" "25.9" "21.8" "26.8" "22.8" "" "" "" "" "" "" "" "" "" "" "21.8" "19.5" "17.0" "16.8" "10.8" "20.2" "21.9" "18.0" "24.6" "22.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017551033698803081" "False" "Medium" "IsMasterProtein" "Q6RI45" "Bromodomain and WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=BRWD3 PE=1 SV=2" "0.042" "False" "1.363" "0" "1" "1" "1" "1802" "203.5" "7.84" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus" "" "Pf00400, Pf00439" "254065" "ENSG00000165288" "BRWD3" "C9IZ39; C9J3F3; hsa:254065; Q2T9J6; Q5JRN1; Q6RI37; Q6RI42; Q6RI44; Q6RI45; Q8N916" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-755631417007269915" "False" "Medium" "IsMasterProtein" "Q8NEE8" "Tetratricopeptide repeat protein 16 OS=Homo sapiens OX=9606 GN=TTC16 PE=1 SV=2" "0.042" "False" "1.363" "1" "1" "1" "1" "873" "98.2" "9.01" "2.27" "1" "" "" "" "Pf00515" "158248" "ENSG00000167094" "TTC16" "B4DYG4; B5ME24; hsa:158248; Q5JU66; Q8NEE8; Q96M72" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1997120607862774840" "False" "Medium" "IsMasterProtein" "O00189" "AP-4 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP4M1 PE=1 SV=2" "0.042" "False" "1.356" "2" "1" "1" "1" "453" "49.9" "7.20" "2.56" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00928, Pf01217" "9179" "ENSG00000221838" "AP4M1" "D6W5U1; hsa:9179; O00189; Q8WV65; Q9UHK9" "Lysosome Vesicle Biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3806564738349929422" "False" "Medium" "IsMasterProtein" "Q9Y6U3" "Scinderin OS=Homo sapiens OX=9606 GN=SCIN PE=1 SV=4" "0.042" "False" "1.351" "1" "1" "2" "1" "715" "80.4" "5.71" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "85477" "ENSG00000006747" "SCIN" "A8K2U8; hsa:85477; Q8NBZ6; Q8WU97; Q96JC7; Q96PY2; Q9Y6U3" "" "Ebola virus infection in host; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2817610694198924296" "False" "Medium" "IsMasterProtein" "P62841" "Small ribosomal subunit protein uS19 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2" "0.043" "False" "1.346" "4" "1" "1" "1" "145" "17.0" "10.39" "2.51" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00203" "6209" "ENSG00000115268" "RPS15" "A5D8V9; hsa:6209; P11174; P62841; Q3KRA1; Q9UDC2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318548072324511589" "False" "Medium" "IsMasterProtein" "Q9UPQ4" "E3 ubiquitin-protein ligase TRIM35 OS=Homo sapiens OX=9606 GN=TRIM35 PE=1 SV=2" "0.043" "False" "1.339" "1" "1" "1" "1" "493" "56.5" "7.11" "2.74" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445, Pf13765" "23087" "ENSG00000104228" "TRIM35" "hsa:23087; Q86XQ0; Q8WVA4; Q9UPQ4" "Interferon gamma signaling" "Interactome of polycomb repressive complex 2 (PRC2)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9000438294968273418" "False" "Medium" "IsMasterProtein" "Q9H173" "Nucleotide exchange factor SIL1 OS=Homo sapiens OX=9606 GN=SIL1 PE=1 SV=1" "0.044" "False" "1.337" "2" "1" "1" "1" "461" "52.1" "5.36" "2.35" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "other molecular function" "Pf08609" "64374" "ENSG00000120725" "SIL1" "D3DQC2; hsa:64374; Q8N2L3; Q9H173" "" "Primary ovarian insufficiency" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "308542735586844623" "False" "Medium" "IsMasterProtein" "Q53FP2" "Novel acetylcholine receptor chaperone OS=Homo sapiens OX=9606 GN=TMEM35A PE=1 SV=2" "0.044" "False" "1.337" "4" "1" "1" "1" "167" "18.4" "10.08" "2.62" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "59353" "ENSG00000126950" "TMEM35A" "hsa:59353; Q53FP2; Q9H7Y3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2353496537959023013" "False" "Medium" "IsMasterProtein" "Q5VUG0" "Scm-like with four MBT domains protein 2 OS=Homo sapiens OX=9606 GN=SFMBT2 PE=1 SV=1" "0.044" "False" "1.336" "1" "1" "1" "1" "894" "100.5" "6.55" "2.27" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00536, Pf02820, Pf12140" "57713" "ENSG00000198879" "SFMBT2" "A7MD09; hsa:57713; Q5VUG0; Q9HCF5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7282170055528227037" "False" "Medium" "IsMasterProtein" "Q9UI17" "Dimethylglycine dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DMGDH PE=1 SV=2" "0.045" "False" "1.330" "2" "1" "1" "1" "866" "96.8" "7.62" "2.69" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "29958" "ENSG00000132837" "DMGDH" "B2RBN0; B4E1J9; hsa:29958; Q9UI17" "Choline catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6632846458664890801" "False" "Medium" "IsMasterProtein" "Q9UK23" "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGPA PE=1 SV=2" "0.045" "False" "1.330" "2" "1" "1" "1" "515" "56.0" "6.60" "1.80" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi" "other molecular function" "Pf09992" "51172" "ENSG00000103174" "NAGPA" "B2RAS1; hsa:51172; Q96EJ8; Q9UK23" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480743538418204073" "False" "Medium" "IsMasterProtein" "Cont_P02777" "Platelet factor 4 OS=Bos taurus OX=9913 GN=PF4 PE=1 SV=1" "0.045" "True" "1.329" "9" "1" "1" "1" "88" "9.5" "6.52" "2.69" "1" "stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00048" "" "" "PF4" "P02777" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8437965729251271503" "False" "Medium" "IsMasterProtein" "Q969P0" "Immunoglobulin superfamily member 8 OS=Homo sapiens OX=9606 GN=IGSF8 PE=1 SV=1" "0.045" "False" "1.327" "1" "1" "1" "1" "613" "65.0" "8.00" "2.86" "1" "developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf07686" "93185" "ENSG00000162729" "IGSF8" "hsa:93185; Q8NG09; Q969P0; Q96DP4; Q9BTG9" "" "11p11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842001087563209976" "False" "Medium" "IsMasterProtein" "Q9NVN8" "Guanine nucleotide-binding protein-like 3-like protein OS=Homo sapiens OX=9606 GN=GNL3L PE=1 SV=1" "0.045" "False" "1.325" "1" "1" "1" "1" "582" "65.5" "8.44" "2.62" "1" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf01926" "54552" "ENSG00000130119" "GNL3L" "hsa:54552; Q9NVN8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7374659774527651574" "False" "Medium" "IsMasterProtein" "Q5T5P2" "Sickle tail protein homolog OS=Homo sapiens OX=9606 GN=KIAA1217 PE=1 SV=2" "0.045" "False" "1.320" "0" "1" "1" "1" "1943" "214.0" "7.06" "2.27" "1" "developmental processes" "cytoskeleton;other cell component" "" "Pf03915" "56243" "ENSG00000120549" "KIAA1217" "A5LHW9; A6NLF3; A6PVQ5; A6PVQ6; A6PVQ7; B9EGK4; hsa:56243; Q4KMG4; Q5T5P2; Q5T5P3; Q5T7H3; Q6MZZ6; Q6ZUI4; Q8WV45; Q9NSR2; Q9ULK3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1972562091752172345" "False" "Medium" "IsMasterProtein" "O14523" "Phospholipid transfer protein C2CD2L OS=Homo sapiens OX=9606 GN=C2CD2L PE=1 SV=3" "0.045" "False" "1.319" "1" "1" "1" "1" "706" "76.1" "7.69" "2.41" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00168, Pf18696" "9854" "ENSG00000172375" "C2CD2L" "hsa:9854; O14523; Q86UT7; Q86V04; Q8N522; Q8TBN4; Q96G10" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4276327742936350895" "False" "Medium" "IsMasterProtein" "Q9H582" "Zinc finger protein 644 OS=Homo sapiens OX=9606 GN=ZNF644 PE=1 SV=2" "0.046" "False" "1.314" "1" "1" "1" "1" "1327" "149.5" "8.16" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "84146" "ENSG00000122482" "ZNF644" "A2RU71; hsa:84146; Q2TAM0; Q5TCC0; Q6BEP7; Q6P446; Q6PI06; Q7LG67; Q9H582; Q9ULJ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1340431599886036183" "False" "Medium" "IsMasterProtein" "O60783" "Small ribosomal subunit protein uS14m OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1" "0.046" "False" "1.312" "7" "1" "1" "1" "128" "15.1" "11.41" "0.00" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00253" "63931" "ENSG00000120333" "MRPS14" "hsa:63931; O60783; Q5R358" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.955" "1.003" "0.992" "0.959" "0.999" "0.991" "0.879" "0.973" "0.911" "387.7" "370.3" "388.9" "384.7" "371.8" "387.5" "384.2" "340.7" "377.1" "353.0" "" "" "" "" "" "" "" "" "" "" "343.8" "306.8" "339.4" "287.7" "310.0" "355.9" "324.7" "281.6" "345.9" "353.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6300586683513148561" "False" "Medium" "IsMasterProtein" "Q8WWQ0" "PH-interacting protein OS=Homo sapiens OX=9606 GN=PHIP PE=1 SV=2" "0.046" "False" "1.309" "0" "1" "1" "1" "1821" "206.6" "8.85" "2.57" "1" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf00439" "55023" "ENSG00000146247" "PHIP" "A7J992; B2RPK4; hsa:55023; Q05CQ9; Q5VVH4; Q66I29; Q69YV1; Q8NBZ5; Q8WWQ0; Q96H52; Q96ME2; Q9H261" "RHOBTB2 GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1077886033734645757" "False" "Medium" "IsMasterProtein" "Q5SQI0" "Alpha-tubulin N-acetyltransferase 1 OS=Homo sapiens OX=9606 GN=ATAT1 PE=1 SV=1" "0.046" "False" "1.308" "2" "1" "1" "1" "421" "46.8" "9.95" "2.47" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf05301" "79969" "ENSG00000137343; ENSG00000206488; ENSG00000223752; ENSG00000229061; ENSG00000231257; ENSG00000234549; ENSG00000235658" "ATAT1" "A2AB28; hsa:79969; Q3LIB0; Q5JP39; Q5JP40; Q5JP42; Q5SQI0; Q5SQI1; Q5SU03; Q86X42; Q8NDK9; Q9BRS1; Q9H8X5" "Cilium Assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2559725886688787495" "False" "Medium" "IsMasterProtein" "Q8WYP3" "Ras and Rab interactor 2 OS=Homo sapiens OX=9606 GN=RIN2 PE=1 SV=1" "0.046" "False" "1.308" "1" "1" "4" "1" "895" "100.1" "6.58" "8.62" "1" "transport;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00788, Pf02204" "54453" "ENSG00000132669" "RIN2" "hsa:54453; Q00425; Q5TFT8; Q8WYP3; Q9BQL3; Q9H071" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.031" "1.055" "0.937" "0.899" "0.865" "1.003" "0.963" "0.873" "0.371" "423.6" "436.8" "447.1" "397.1" "380.6" "366.5" "424.7" "408.1" "369.8" "157.4" "" "" "" "" "" "" "" "" "" "" "375.6" "361.8" "390.1" "297.0" "317.4" "336.6" "359.0" "337.3" "339.2" "157.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4545350310808249062" "False" "Medium" "IsMasterProtein" "Q4AE62" "tRNA-queuosine alpha-mannosyltransferase OS=Homo sapiens OX=9606 GN=GTDC1 PE=1 SV=1" "0.046" "False" "1.307" "2" "1" "1" "1" "458" "52.6" "7.25" "2.19" "1" "" "" "other molecular function" "Pf00534, Pf12038" "79712" "ENSG00000121964" "GTDC1" "A0A087X2H5; A8K5P2; D3DP81; G1UFN1; G5EA49; H7BYJ5; hsa:79712; Q4AE62; Q53SM7; Q53TC5; Q6P7E7; Q6PJB6; Q6WKW6; Q9HAE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4170934918181062519" "False" "Medium" "IsMasterProtein" "Q9H765" "Ankyrin repeat and SOCS box protein 8 OS=Homo sapiens OX=9606 GN=ASB8 PE=1 SV=1" "0.046" "False" "1.306" "4" "1" "1" "1" "288" "31.6" "5.83" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction" "cytosol" "" "Pf07525, Pf12796" "140461" "ENSG00000177981" "ASB8" "A8K1P2; hsa:140461; Q547Q2; Q9H765" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.738" "0.554" "0.777" "1.030" "0.785" "0.884" "1.003" "0.813" "0.508" "18.9" "14.0" "10.5" "14.7" "19.5" "14.9" "16.7" "19.0" "15.4" "9.6" "" "" "" "" "" "" "" "" "" "" "16.8" "11.6" "9.1" "11.0" "16.3" "13.6" "14.1" "15.7" "14.1" "9.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4126622846664947622" "False" "Medium" "IsMasterProtein" "Q96H35" "Probable RNA-binding protein 18 OS=Homo sapiens OX=9606 GN=RBM18 PE=1 SV=1" "0.046" "False" "1.303" "5" "1" "1" "1" "190" "21.6" "9.44" "0.00" "1" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "92400" "ENSG00000119446" "RBM18" "B3KQ89; hsa:92400; Q96H35" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7218272349989461582" "False" "Medium" "IsMasterProtein" "Q9H211" "DNA replication factor Cdt1 OS=Homo sapiens OX=9606 GN=CDT1 PE=1 SV=3" "0.046" "False" "1.302" "1" "1" "1" "1" "546" "60.4" "9.77" "2.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08839, Pf16679" "81620" "ENSG00000167513" "CDT1" "hsa:81620; Q86XX9; Q96CJ5; Q96GK5; Q96H67; Q96HE6; Q9BWM0; Q9H211" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of the pre-replicative complex; G1/S-Specific Transcription" "Retinoblastoma gene in cancer; DNA replication" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4612201996851868206" "False" "Medium" "IsMasterProtein" "O60281" "Zinc finger protein 292 OS=Homo sapiens OX=9606 GN=ZNF292 PE=1 SV=3" "0.046" "False" "1.301" "1" "1" "1" "1" "2723" "304.6" "7.39" "3.95" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "23036" "ENSG00000188994" "ZNF292" "hsa:23036; O60281; Q5W0B2; Q7Z3L7; Q9H8G3; Q9H8J4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6126928489973910912" "False" "Medium" "IsMasterProtein" "E9PKD4" "Nuclear pore complex-interacting protein family member A5 OS=Homo sapiens OX=9606 GN=NPIPA5 PE=2 SV=1" "0.046" "False" "1.301" "4" "1" "1" "1" "350" "40.1" "9.36" "2.16" "1" "" "" "" "Pf06409" "100288332" "ENSG00000183793" "NPIPA5" "E9PKD4; hsa:100288332; Q0P618" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1791132844314588076" "False" "Medium" "IsMasterProtein" "O43306" "Adenylate cyclase type 6 OS=Homo sapiens OX=9606 GN=ADCY6 PE=1 SV=2" "0.048" "False" "1.300" "1" "1" "1" "1" "1168" "130.5" "8.22" "2.74" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00211, Pf06327, Pf16214" "112" "ENSG00000174233" "ADCY6" "hsa:112; O43306; Q9NR75; Q9UDB0" "FCGR3A-mediated IL10 synthesis; G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Adrenaline,noradrenaline inhibits insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Adenylate cyclase activating pathway; Hedgehog 'off' state" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Phosphodiesterases in neuronal function; Thermogenesis; Envelope proteins and their potential roles in EDMD physiopathology; Ciliopathies; Vasopressin-regulated water reabsorption; Calcium regulation in cardiac cells" "24" "0" "0.977" "1.111" "1.132" "1.217" "0.950" "1.093" "1.099" "0.777" "1.875" "37.9" "37.0" "42.1" "42.8" "46.1" "36.0" "41.4" "41.6" "29.4" "71.0" "" "" "" "" "" "" "" "" "" "" "33.6" "30.6" "36.7" "32.0" "38.4" "33.0" "35.0" "34.4" "27.0" "71.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3433213539616798007" "False" "Medium" "IsMasterProtein" "Q9P2W9" "Syntaxin-18 OS=Homo sapiens OX=9606 GN=STX18 PE=1 SV=1" "0.048" "False" "1.299" "6" "1" "1" "1" "335" "38.7" "5.49" "2.28" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10496" "53407" "ENSG00000168818" "STX18" "hsa:53407; Q596L3; Q5TZP5; Q9P2W9" "COPI-dependent Golgi-to-ER retrograde traffic" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831642431690340984" "False" "Medium" "IsMasterProtein" "Q9NRU3" "Metal transporter CNNM1 OS=Homo sapiens OX=9606 GN=CNNM1 PE=1 SV=3" "0.048" "False" "1.295" "1" "1" "1" "1" "951" "104.3" "6.28" "2.90" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00571, Pf01595" "26507" "ENSG00000119946" "CNNM1" "hsa:26507; Q4QQG7; Q4QQH8; Q4QQP9; Q9NRU3; Q9NT45" "" "" "0" "0" "1.372" "0.917" "1.957" "1.559" "0.701" "1.750" "1.283" "1.078" "0.534" "201.3" "276.1" "184.5" "393.9" "313.8" "141.1" "352.3" "258.3" "216.9" "107.4" "" "" "" "" "" "" "" "" "" "" "178.5" "228.7" "161.0" "294.6" "261.7" "129.6" "297.7" "213.5" "198.9" "107.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "742204205705091677" "False" "Medium" "IsMasterProtein" "Q16787" "Laminin subunit alpha-3 OS=Homo sapiens OX=9606 GN=LAMA3 PE=1 SV=3" "0.048" "False" "1.292" "0" "1" "1" "1" "3333" "366.4" "7.24" "1.83" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00052, Pf00053, Pf00055, Pf02210, Pf06008, Pf06009" "3909" "ENSG00000053747" "LAMA3" "B0YJ33; hsa:3909; Q13679; Q13680; Q16787; Q6VU67; Q6VU68; Q6VU69; Q76E14; Q96TG0" "Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling; Anchoring fibril formation; Type I hemidesmosome assembly" "Alpha 6 beta 4 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Small cell lung cancer; Pleural mesothelioma" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5976124044734252657" "False" "Medium" "IsMasterProtein" "Q8WYA0" "Intraflagellar transport protein 81 homolog OS=Homo sapiens OX=9606 GN=IFT81 PE=1 SV=1" "0.048" "False" "1.291" "1" "1" "1" "1" "676" "79.7" "8.82" "1.79" "1" "cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf18383" "28981" "ENSG00000122970" "IFT81" "Q2YDY1; Q8NB51; Q8WYA0; Q9BSV2; Q9UNY8" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Alstrom syndrome; Bardet-Biedl syndrome" "7" "0" "1.090" "0.979" "0.848" "1.095" "1.102" "1.256" "1.050" "0.815" "0.789" "61.6" "67.1" "60.3" "52.2" "67.5" "67.9" "77.4" "64.7" "50.2" "48.6" "" "" "" "" "" "" "" "" "" "" "54.6" "55.6" "52.6" "39.1" "56.2" "62.4" "65.4" "53.5" "46.1" "48.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3194956700439507601" "False" "Medium" "IsMasterProtein" "Q9UPT5" "Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3" "0.049" "False" "1.286" "1" "1" "1" "1" "735" "83.3" "6.79" "2.43" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03081, Pf20669" "23265" "ENSG00000182473" "EXOC7" "B5MC69; B8XXP2; hsa:23265; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32; Q9UPT5" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Angiopoietin-like protein 8 regulatory pathway; Ciliary landscape" "5" "0" "0.677" "0.566" "0.918" "0.609" "0.697" "0.887" "0.377" "0.667" "6.837" "52.0" "35.2" "29.4" "47.7" "31.6" "36.3" "46.1" "19.6" "34.7" "355.5" "" "" "" "" "" "" "" "" "" "" "46.1" "29.1" "25.7" "35.7" "26.4" "33.3" "39.0" "16.2" "31.8" "355.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6288019369957084060" "False" "Medium" "IsMasterProtein" "Q99550" "M-phase phosphoprotein 9 OS=Homo sapiens OX=9606 GN=MPHOSPH9 PE=1 SV=7" "0.049" "False" "1.286" "1" "1" "1" "1" "1183" "132.9" "6.24" "2.69" "1" "other biological processes" "other membranes;cytoskeleton;ER/Golgi" "" "" "10198" "ENSG00000051825" "MPHOSPH9" "A0A0A0MTP3; A1L486; A6NEE2; B3KR87; hsa:10198; Q99550; Q9H976; U3KQ28" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6041789456780184752" "False" "Medium" "IsMasterProtein" "P22304" "Iduronate 2-sulfatase OS=Homo sapiens OX=9606 GN=IDS PE=1 SV=1" "0.049" "False" "1.285" "1" "1" "1" "1" "550" "61.8" "5.45" "2.71" "1" "protein metabolism;other metabolic processes" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "3423" "ENSG00000010404" "IDS" "D3DWT4; hsa:3423; P22304; Q14604; Q9BRM3" "HS-GAG degradation; CS/DS degradation; MPS II - Hunter syndrome" "Glycosaminoglycan degradation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1620287855834413498" "False" "Medium" "IsMasterProtein" "Q86XE3" "Calcium uptake protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=MICU3 PE=1 SV=1" "0.049" "False" "1.285" "2" "1" "1" "1" "530" "60.7" "8.21" "2.89" "1" "transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13499" "286097" "ENSG00000155970" "MICU3" "hsa:286097; Q86XE3; Q8IYZ3" "Processing of SMDT1" "" "2" "0" "0.918" "0.844" "0.986" "0.817" "0.986" "1.042" "0.939" "0.832" "0.713" "198.3" "182.2" "167.4" "195.5" "162.1" "195.6" "206.7" "186.2" "165.0" "141.5" "" "" "" "" "" "" "" "" "" "" "175.9" "150.9" "146.0" "146.2" "135.1" "179.7" "174.7" "153.9" "151.4" "141.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1822909111869695026" "False" "Medium" "IsMasterProtein" "P32238" "Cholecystokinin receptor type A OS=Homo sapiens OX=9606 GN=CCKAR PE=1 SV=1" "0.049" "False" "1.284" "3" "1" "1" "1" "428" "47.8" "9.20" "2.05" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00001, Pf09193" "886" "ENSG00000163394" "CCKAR" "B2R9Z5; hsa:886; P32238" "G alpha (q) signalling events; Peptide ligand-binding receptors" "Peptide GPCRs; GPCRs, class A rhodopsin-like" "4" "0" "1.060" "1.016" "1.028" "0.978" "1.035" "1.069" "0.927" "0.986" "0.989" "121.4" "128.7" "123.4" "124.9" "118.8" "125.7" "129.9" "112.6" "119.8" "120.1" "" "" "" "" "" "" "" "" "" "" "107.7" "106.6" "107.6" "93.4" "99.0" "115.5" "109.8" "93.1" "109.9" "120.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4987292281237204218" "False" "Medium" "IsMasterProtein" "D6RIA3" "Uncharacterized protein C4orf54 OS=Homo sapiens OX=9606 GN=C4orf54 PE=1 SV=1" "0.049" "False" "1.284" "0" "1" "1" "1" "1793" "190.0" "8.98" "2.22" "1" "" "" "" "Pf15232" "" "ENSG00000248713" "C4orf54" "D6RIA3" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6361310259065089724" "False" "Medium" "IsMasterProtein" "O75473" "Leucine-rich repeat-containing G-protein coupled receptor 5 OS=Homo sapiens OX=9606 GN=LGR5 PE=1 SV=1" "0.049" "False" "1.281" "1" "1" "1" "1" "907" "99.9" "6.60" "2.73" "1" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00001, Pf01462, Pf12799, Pf13855" "8549" "ENSG00000139292" "LGR5" "D8MCT0; hsa:8549; O75473; Q4VAM0; Q4VAM2; Q9UP75" "Regulation of FZD by ubiquitination" "" "1" "0" "0.699" "0.620" "0.666" "0.441" "0.645" "0.507" "0.643" "0.606" "0.238" "864.4" "604.2" "535.9" "576.0" "380.9" "557.2" "438.5" "555.6" "523.5" "206.1" "" "" "" "" "" "" "" "" "" "" "766.5" "500.5" "467.6" "430.8" "317.6" "511.8" "370.6" "459.3" "480.1" "206.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1072346070458958756" "False" "Medium" "IsMasterProtein" "Q8N2H3" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PYROXD2 PE=1 SV=2" "0.049" "False" "1.281" "1" "1" "1" "1" "581" "63.0" "6.95" "2.26" "1" "cell organization and biogenesis" "mitochondrion" "other molecular function" "Pf01593, Pf13450" "84795" "ENSG00000119943" "PYROXD2" "D3DR61; hsa:84795; Q5TAA9; Q8N2H3; Q9BRQ1" "" "" "0" "0" "1.130" "0.964" "1.090" "0.908" "1.143" "1.146" "1.050" "1.036" "0.194" "125.6" "142.0" "121.1" "136.9" "114.1" "143.6" "144.0" "131.9" "130.2" "24.4" "" "" "" "" "" "" "" "" "" "" "111.4" "117.6" "105.7" "102.4" "95.2" "131.9" "121.7" "109.0" "119.4" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5949318794217667053" "False" "Medium" "IsMasterProtein" "Q6Q759" "Sperm-associated antigen 17 OS=Homo sapiens OX=9606 GN=SPAG17 PE=1 SV=1" "0.049" "False" "1.280" "0" "1" "1" "1" "2223" "251.6" "6.24" "2.82" "1" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytoskeleton;ER/Golgi;other cell component" "" "Pf14874" "200162" "ENSG00000155761" "SPAG17" "Q6Q759; Q8NAZ1; Q9NT21" "" "" "0" "0" "0.890" "0.910" "0.852" "0.704" "0.903" "0.853" "0.877" "0.741" "0.357" "237.5" "211.3" "216.0" "202.3" "167.2" "214.4" "202.5" "208.4" "176.0" "84.7" "" "" "" "" "" "" "" "" "" "" "210.6" "175.0" "188.5" "151.3" "139.4" "196.9" "171.2" "172.2" "161.4" "84.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-623572355680297552" "False" "Medium" "IsMasterProtein" "Q9H1Y3" "Opsin-3 OS=Homo sapiens OX=9606 GN=OPN3 PE=1 SV=1" "0.049" "False" "1.280" "1" "1" "1" "1" "402" "44.8" "9.14" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00001" "23596" "ENSG00000054277" "OPN3" "hsa:23596; Q8IX08; Q9H1Y3; Q9Y344" "G alpha (i) signalling events; Opsins" "GPCRs, class A rhodopsin-like; Orexin receptor pathway" "4" "0" "0.794" "0.710" "0.806" "0.653" "0.436" "0.433" "0.749" "0.756" "0.800" "253.1" "201.0" "179.7" "203.9" "165.2" "110.4" "109.5" "189.6" "191.5" "202.4" "" "" "" "" "" "" "" "" "" "" "224.5" "166.5" "156.8" "152.5" "137.7" "101.4" "92.6" "156.7" "175.6" "202.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2041332710814858625" "False" "Medium" "IsMasterProtein" "Q9NRY4" "Rho GTPase-activating protein 35 OS=Homo sapiens OX=9606 GN=ARHGAP35 PE=1 SV=3" "0.049" "False" "1.280" "0" "1" "1" "1" "1499" "170.4" "6.64" "2.36" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00071, Pf00620, Pf16512, Pf19518" "2909" "ENSG00000160007" "ARHGAP35" "A7E2A4; hsa:2909; Q14452; Q9C0E1; Q9NRY4" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; RND2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Sema4D mediated inhibition of cell attachment and migration; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "Focal adhesion; Regulation of actin cytoskeleton" "18" "0" "0.850" "0.954" "0.965" "0.997" "0.721" "0.774" "0.819" "1.194" "2.682" "86.0" "73.0" "82.0" "82.9" "85.7" "62.0" "66.6" "70.4" "102.7" "230.6" "" "" "" "" "" "" "" "" "" "" "76.2" "60.5" "71.5" "62.0" "71.5" "56.9" "56.3" "58.2" "94.2" "230.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-552200007576109584" "False" "Medium" "IsMasterProtein" "P56937" "3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 OS=Homo sapiens OX=9606 GN=HSD17B7 PE=1 SV=1" "0.049" "False" "1.279" "2" "1" "1" "1" "341" "38.2" "8.10" "2.58" "1" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00106" "51478" "ENSG00000132196" "HSD17B7" "hsa:51478; P56937; Q5T246; Q7Z4V9; Q8WWS2; Q9UF00" "Cholesterol biosynthesis" "Androgen receptor network in prostate cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Steroid biosynthesis; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "7" "0" "1.018" "0.951" "0.885" "0.850" "1.002" "0.930" "0.927" "0.992" "1.057" "215.2" "219.0" "204.6" "190.4" "183.0" "215.6" "200.2" "199.4" "213.4" "227.4" "" "" "" "" "" "" "" "" "" "" "190.8" "181.4" "178.6" "142.4" "152.6" "198.0" "169.2" "164.8" "195.7" "227.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3548704678811192106" "False" "Medium" "IsMasterProtein" "Q8ND30" "Liprin-beta-2 OS=Homo sapiens OX=9606 GN=PPFIBP2 PE=1 SV=3" "0.050" "False" "1.276" "1" "1" "1" "1" "876" "98.5" "6.27" "2.02" "1" "cell organization and biogenesis" "cytosol;other cell component" "other molecular function" "Pf00536, Pf07647" "8495" "ENSG00000166387" "PPFIBP2" "B7Z433; E9PK77; hsa:8495; O75337; Q8ND30; Q8WW26" "Receptor-type tyrosine-protein phosphatases" "Ectoderm differentiation" "2" "0" "0.666" "0.660" "0.697" "0.562" "0.595" "0.551" "0.584" "0.739" "1.162" "90.6" "60.4" "59.8" "63.2" "51.0" "53.9" "49.9" "53.0" "67.0" "105.3" "" "" "" "" "" "" "" "" "" "" "80.4" "50.0" "52.2" "47.3" "42.5" "49.5" "42.2" "43.8" "61.4" "105.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847516572355730355" "False" "Medium" "IsMasterProtein" "P46020" "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform OS=Homo sapiens OX=9606 GN=PHKA1 PE=1 SV=2" "0.050" "False" "1.276" "1" "1" "3" "1" "1223" "137.2" "6.19" "4.69" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00723, Pf19292" "5255" "ENSG00000067177" "PHKA1" "B7ZL05; B7ZL07; hsa:5255; P46020; Q2M3D7" "Glycogen breakdown (glycogenolysis)" "Glycogen synthesis and degradation" "2" "0" "0.760" "0.869" "0.915" "0.751" "0.775" "0.937" "0.775" "0.682" "1.018" "437.3" "332.5" "380.0" "400.0" "328.5" "339.0" "409.9" "339.1" "298.2" "445.4" "" "" "" "" "" "" "" "" "" "" "387.8" "275.4" "331.5" "299.2" "274.0" "311.4" "346.5" "280.3" "273.5" "445.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2307054692801203327" "False" "Low" "IsMasterProtein" "Q96D70" "R3H domain-containing protein 4 OS=Homo sapiens OX=9606 GN=R3HDM4 PE=1 SV=3" "0.050" "False" "1.274" "3" "1" "1" "1" "268" "30.3" "8.56" "2.00" "1" "" "nucleus" "nucleic acid binding activity" "Pf01424, Pf13902" "91300" "ENSG00000198858" "R3HDM4" "hsa:91300; Q96D70" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6630834338297740340" "False" "Low" "IsMasterProtein" "Q86X59" "Putative uncharacterized protein LINC02875 OS=Homo sapiens OX=9606 GN=LINC02875 PE=5 SV=2" "0.050" "False" "1.273" "5" "1" "1" "1" "251" "25.4" "10.36" "0.00" "1" "" "" "" "" "" "" "LINC02875" "Q86X59" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1548878880558889845" "False" "Low" "IsMasterProtein" "P23470" "Receptor-type tyrosine-protein phosphatase gamma OS=Homo sapiens OX=9606 GN=PTPRG PE=1 SV=4" "0.050" "False" "1.270" "1" "1" "1" "1" "1445" "161.9" "6.42" "0.00" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00041, Pf00102, Pf00194" "5793" "ENSG00000144724" "PTPRG" "B2RU12; B7ZLX5; hsa:5793; P23470; Q15623; Q59EE0; Q68DU5" "" "" "0" "0" "0.951" "0.789" "0.990" "1.126" "0.903" "1.019" "1.233" "1.175" "0.529" "75.3" "71.6" "59.4" "74.5" "84.7" "67.9" "76.7" "92.8" "88.5" "39.8" "" "" "" "" "" "" "" "" "" "" "66.8" "59.3" "51.8" "55.7" "70.7" "62.4" "64.8" "76.7" "81.1" "39.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5917853148596290385" "False" "Low" "IsMasterProtein" "Q5SZD4" "Glycine N-acyltransferase-like protein 3 OS=Homo sapiens OX=9606 GN=GLYATL3 PE=1 SV=3" "0.051" "False" "1.267" "3" "1" "1" "1" "288" "32.7" "8.84" "2.30" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf06021, Pf08444" "389396" "ENSG00000203972" "GLYATL3" "hsa:389396; Q5SZD4" "Aspirin ADME; Conjugation of salicylate with glycine; Conjugation of benzoate with glycine" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9128345059399950903" "False" "Low" "IsMasterProtein" "P83436" "Conserved oligomeric Golgi complex subunit 7 OS=Homo sapiens OX=9606 GN=COG7 PE=1 SV=1" "0.051" "False" "1.266" "1" "1" "1" "1" "770" "86.3" "5.47" "2.22" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "" "Pf10191" "91949" "ENSG00000168434" "COG7" "hsa:91949; P83436; Q6UWU7" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2363368900293969102" "False" "Low" "IsMasterProtein" "Q9HB75" "p53-induced death domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIDD1 PE=1 SV=2" "0.051" "False" "1.266" "1" "1" "1" "1" "910" "99.6" "6.43" "2.09" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf00791, Pf10461, Pf13855" "55367" "ENSG00000177595" "PIDD1" "hsa:55367; Q59FD1; Q59H10; Q59HC7; Q7Z4P8; Q8NC89; Q8NDL2; Q96C25; Q9HB75; Q9NRE6" "TP53 Regulates Transcription of Caspase Activators and Caspases" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; ATM signaling pathway; p53 transcriptional gene network; DNA damage response" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4888676530146664600" "False" "Low" "IsMasterProtein" "P55198" "Protein AF-17 OS=Homo sapiens OX=9606 GN=MLLT6 PE=1 SV=3" "0.051" "False" "1.264" "2" "1" "1" "1" "1093" "112.0" "8.62" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "nucleus" "other molecular function" "Pf13832" "4302" "ENSG00000275023; ENSG00000275851" "MLLT6" "hsa:4302; P55198; Q59F28; Q96IU3; Q9H5F6; Q9UF49" "" "17q12 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "1" "" "-7969959000989021007" "False" "Low" "IsMasterProtein" "P38935" "DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3" "0.052" "False" "1.259" "1" "1" "1" "1" "993" "109.1" "8.97" "2.20" "1" "cell organization and biogenesis;RNA metabolism OR transcription" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01424, Pf01428, Pf13086, Pf13087, Pf21138" "3508" "ENSG00000132740" "IGHMBP2" "A0PJD2; hsa:3508; P38935; Q00443; Q14177" "" "" "0" "0" "1.028" "1.626" "1.360" "0.857" "0.941" "1.259" "0.973" "1.011" "7.996" "7.2" "7.4" "11.7" "9.8" "6.2" "6.8" "9.1" "7.0" "7.3" "57.5" "" "" "" "" "" "" "" "" "" "" "6.4" "6.1" "10.2" "7.3" "5.1" "6.2" "7.7" "5.8" "6.7" "57.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8409014804587651307" "False" "Low" "IsMasterProtein" "Q8NDA8" "Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens OX=9606 GN=MROH1 PE=1 SV=3" "0.052" "False" "1.259" "0" "1" "1" "1" "1641" "181.1" "6.89" "1.84" "1" "" "other cell component" "" "Pf02985, Pf21047" "727957" "ENSG00000179832" "MROH1" "C9JWM5; D3DWL5; hsa:727957; Q0P612; Q569G6; Q6NVW4; Q8N230; Q8NAD1; Q8ND95; Q8NDA8; Q96JJ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4474106479109079676" "False" "Low" "IsMasterProtein" "O00422" "Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1" "0.052" "False" "1.255" "6" "1" "1" "1" "153" "17.6" "9.35" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06487" "10284" "ENSG00000150459" "SAP18" "B2R494; hsa:10284; O00422; Q2TTR4; Q6IAW9; Q8N606; Q9UF14; X6RAL5" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway" "Hedgehog signaling pathway" "5" "0" "1.047" "0.964" "0.920" "0.914" "1.062" "0.890" "1.005" "0.925" "2.436" "100.3" "105.0" "96.7" "92.3" "91.7" "106.5" "89.2" "100.8" "92.8" "244.3" "" "" "" "" "" "" "" "" "" "" "88.9" "87.0" "84.3" "69.0" "76.4" "97.8" "75.4" "83.3" "85.1" "244.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "776622353869952197" "False" "Low" "IsMasterProtein" "O60262" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 OS=Homo sapiens OX=9606 GN=GNG7 PE=1 SV=1" "0.053" "False" "1.254" "10" "1" "1" "1" "68" "7.5" "8.51" "1.86" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2788" "ENSG00000176533" "GNG7" "B2R496; hsa:2788; O60262" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5997632050867013674" "False" "Low" "IsMasterProtein" "Q9UGR2" "Zinc finger CCCH domain-containing protein 7B OS=Homo sapiens OX=9606 GN=ZC3H7B PE=1 SV=2" "0.053" "False" "1.254" "1" "1" "1" "1" "977" "109.8" "7.25" "1.87" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf13181" "23264" "ENSG00000100403" "ZC3H7B" "A7YY88; B2RCA4; hsa:23264; Q5TFX9; Q8TBT9; Q9H8B6; Q9UGQ9; Q9UGR0; Q9UGR1; Q9UGR2; Q9UK03; Q9UPW9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2485392268921902957" "False" "Low" "IsMasterProtein" "Q6ZN54" "Differentially expressed in FDCP 8 homolog OS=Homo sapiens OX=9606 GN=DEF8 PE=1 SV=2" "0.053" "False" "1.252" "1" "1" "1" "1" "512" "58.7" "6.52" "2.62" "1" "other biological processes" "" "other molecular function" "Pf00130, Pf13901" "54849" "ENSG00000140995" "DEF8" "B3KT65; B4DK62; B4E0S9; B7Z3H6; H3BUG7; hsa:54849; Q6ZN54; Q8N8N3; Q9NXL0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8250639024737902778" "False" "Low" "IsMasterProtein" "O14727" "Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2" "0.054" "False" "1.248" "1" "1" "1" "1" "1248" "141.7" "6.40" "3.29" "1" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00619, Pf00931, Pf17908, Pf21296" "317" "ENSG00000120868" "APAF1" "B2RMX8; hsa:317; O14727; O43297; Q7Z438; Q9BXZ6; Q9UBZ5; Q9UGN8; Q9UGN9; Q9UGP0; Q9UJ58; Q9UJ59; Q9UJ60; Q9UJ61; Q9UJ62; Q9UJ63; Q9UJ64; Q9UJ65; Q9UJ66; Q9UJ67; Q9UNC9" "Neutrophil degranulation; Transcriptional Regulation by E2F6; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity" "miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "28" "0" "0.932" "0.908" "0.938" "0.925" "0.990" "0.984" "1.085" "0.762" "0.375" "542.9" "506.1" "492.8" "509.0" "502.1" "537.4" "534.1" "589.0" "413.8" "203.6" "" "" "" "" "" "" "" "" "" "" "481.4" "419.2" "430.0" "380.7" "418.7" "493.7" "451.4" "486.8" "379.5" "203.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905087365465039494" "False" "Low" "IsMasterProtein" "Q9Y4Y9" "U6 snRNA-associated Sm-like protein LSm5 OS=Homo sapiens OX=9606 GN=LSM5 PE=1 SV=3" "0.054" "False" "1.247" "7" "1" "1" "1" "91" "9.9" "4.54" "2.28" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "23658" "ENSG00000106355" "LSM5" "hsa:23658; Q9Y4Y9" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "0.951" "1.005" "0.968" "0.966" "1.016" "1.029" "0.983" "0.907" "0.368" "483.7" "459.9" "486.0" "468.2" "467.5" "491.6" "497.8" "475.5" "438.7" "178.0" "" "" "" "" "" "" "" "" "" "" "429.0" "380.9" "424.1" "350.2" "389.8" "451.6" "420.7" "393.0" "402.4" "178.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760728246443025630" "False" "Low" "IsMasterProtein" "Q99707" "Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2" "0.054" "False" "1.246" "1" "1" "1" "1" "1265" "140.4" "5.58" "2.36" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00809, Pf02310, Pf02574, Pf02607, Pf02965" "4548" "ENSG00000116984" "MTR" "A1L4N8; A9Z1W4; B7ZLW7; B9EGF7; hsa:4548; Q99707; Q99713; Q99723" "RHOH GTPase cycle; Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility; Spina bifida" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1860543310075142412" "False" "Low" "IsMasterProtein" "Q02413" "Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2" "0.054" "False" "1.244" "1" "1" "1" "1" "1049" "113.7" "5.03" "3.01" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00028, Pf01049" "1828" "ENSG00000134760" "DSG1" "B7Z845; hsa:1828; Q02413" "Neutrophil degranulation; Formation of the cornified envelope; RND2 GTPase cycle; RND3 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2245217909650069335" "False" "Low" "IsMasterProtein" "Q14573" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 OS=Homo sapiens OX=9606 GN=ITPR3 PE=1 SV=2" "0.054" "False" "1.243" "0" "1" "1" "1" "2671" "303.9" "6.48" "2.48" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3710" "ENSG00000096433" "ITPR3" "hsa:3710; Q14573; Q14649; Q5TAQ2" "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; Effects of PIP2 hydrolysis; Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Sensory perception of sweet, bitter, and umami (glutamate) taste; Ion homeostasis; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; GPR40 pathway; Vitamin D-sensitive calcium signaling in depression; Airway smooth muscle cell contraction; Pleural mesothelioma; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells" "25" "0" "1.042" "0.895" "1.075" "1.035" "1.045" "0.924" "1.013" "1.072" "0.543" "110.9" "115.6" "99.3" "119.3" "114.8" "116.0" "102.5" "112.4" "118.9" "60.3" "" "" "" "" "" "" "" "" "" "" "98.4" "95.7" "86.6" "89.2" "95.7" "106.5" "86.6" "92.9" "109.0" "60.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5786695541572453442" "False" "Low" "IsMasterProtein" "P16144" "Integrin beta-4 OS=Homo sapiens OX=9606 GN=ITGB4 PE=1 SV=5" "0.055" "False" "1.241" "0" "1" "1" "1" "1822" "202.0" "6.09" "2.27" "1" "cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf00362, Pf03160, Pf07965, Pf07974, Pf17205, Pf18372" "3691" "ENSG00000132470" "ITGB4" "A0AVL6; hsa:3691; O14690; O14691; O15339; O15340; O15341; P16144; Q0VF97; Q9UIQ4" "Assembly of collagen fibrils and other multimeric structures; Syndecan interactions; Laminin interactions; Type I hemidesmosome assembly" "Integrin-mediated cell adhesion; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TGF-beta signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Netrin-UNC5B signaling pathway; Nephrotic syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy" "19" "0" "1.045" "0.835" "1.288" "0.986" "1.050" "1.001" "1.056" "0.711" "0.468" "258.3" "270.0" "215.6" "332.7" "254.8" "271.2" "258.5" "272.9" "183.8" "121.0" "" "" "" "" "" "" "" "" "" "" "229.1" "223.7" "188.1" "248.8" "212.4" "249.1" "218.4" "225.6" "168.5" "121.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8896573865465448502" "False" "Low" "IsMasterProtein" "Q12815" "Tastin OS=Homo sapiens OX=9606 GN=TROAP PE=1 SV=3" "0.055" "False" "1.238" "1" "1" "1" "1" "778" "83.8" "7.36" "3.21" "1" "cell adhesion" "other cell component" "" "" "10024" "ENSG00000135451" "TROAP" "F8VSF9; hsa:10024; Q12815; Q6PJU7; Q8N5B2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610265062629889705" "False" "Low" "IsMasterProtein" "Q8IW93" "Rho guanine nucleotide exchange factor 19 OS=Homo sapiens OX=9606 GN=ARHGEF19 PE=1 SV=1" "0.055" "False" "1.238" "1" "1" "1" "1" "802" "89.1" "7.53" "0.00" "1" "cell-cell signaling;stress response;signal transduction;other biological processes" "cytosol" "enzyme regulator activity" "Pf00621, Pf07653" "128272" "ENSG00000142632; ENSG00000291381" "ARHGEF19" "A6NJ04; hsa:128272; Q5TEV2; Q6PJQ4; Q8IW93; Q8N244" "RAC1 GTPase cycle; NRAGE signals death through JNK; RHOA GTPase cycle; CDC42 GTPase cycle; G alpha (12/13) signalling events" "" "5" "0" "1.116" "1.174" "1.159" "1.136" "1.078" "0.995" "1.066" "0.877" "0.827" "159.2" "177.7" "187.0" "184.6" "181.0" "171.7" "158.4" "169.8" "139.6" "131.8" "" "" "" "" "" "" "" "" "" "" "141.2" "147.2" "163.1" "138.0" "150.9" "157.7" "133.9" "140.4" "128.1" "131.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6274679284193459367" "False" "Low" "IsMasterProtein" "Q9BX26" "Synaptonemal complex protein 2 OS=Homo sapiens OX=9606 GN=SYCP2 PE=1 SV=2" "0.055" "False" "1.237" "1" "1" "1" "1" "1530" "175.5" "8.85" "2.02" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf18581, Pf18584" "10388" "ENSG00000196074" "SYCP2" "A2RUE5; hsa:10388; O75763; Q5JX11; Q9BX26; Q9NTX8; Q9UG27" "Meiotic synapsis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-860365839376182297" "False" "Low" "IsMasterProtein" "Q9ULD2" "Microtubule-associated tumor suppressor 1 OS=Homo sapiens OX=9606 GN=MTUS1 PE=1 SV=2" "0.055" "False" "1.230" "1" "1" "1" "1" "1270" "141.3" "7.50" "2.17" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;nucleus" "cytoskeletal activity" "" "57509" "ENSG00000129422" "MTUS1" "A8K135; B2RBJ6; B3KWJ9; B4DH03; B9EGA1; D3DSP8; Q63HJ6; Q659F4; Q6PK49; Q6URW7; Q8N4M6; Q8WTT9; Q9H7T2; Q9ULD2" "" "" "0" "0" "1.070" "1.079" "0.974" "1.036" "1.100" "1.026" "1.162" "1.070" "0.937" "121.4" "129.9" "131.0" "118.2" "125.8" "133.5" "124.6" "141.0" "129.8" "113.7" "" "" "" "" "" "" "" "" "" "" "107.6" "107.6" "114.3" "88.4" "104.9" "122.7" "105.3" "116.6" "119.1" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1198636224090446105" "False" "Low" "IsMasterProtein" "Q5JUK3" "Potassium channel subfamily T member 1 OS=Homo sapiens OX=9606 GN=KCNT1 PE=1 SV=2" "0.055" "False" "1.228" "1" "1" "1" "1" "1230" "138.3" "7.52" "2.01" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf03493, Pf07885" "57582" "ENSG00000107147" "KCNT1" "B3KXF7; B7ZVY4; B9EGP2; G5E9V0; hsa:57582; Q5JUK3; Q9P2C5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7286073100971465543" "False" "Low" "IsMasterProtein" "O95466" "Formin-like protein 1 OS=Homo sapiens OX=9606 GN=FMNL1 PE=1 SV=3" "0.055" "False" "1.227" "1" "1" "1" "1" "1100" "121.8" "5.72" "2.86" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "752" "ENSG00000184922" "FMNL1" "D2DGW2; hsa:752; O95466; Q6DKG5; Q6IBP3; Q86UH1; Q8N671; Q8TDH1; Q96H10" "RHO GTPases Activate Formins; CDC42 GTPase cycle; RAC1 GTPase cycle" "" "3" "0" "1.126" "0.901" "1.256" "1.038" "1.018" "0.965" "0.632" "1.185" "9.939" "84.1" "94.8" "75.8" "105.7" "87.3" "85.6" "81.2" "53.2" "99.7" "836.3" "" "" "" "" "" "" "" "" "" "" "74.6" "78.5" "66.1" "79.0" "72.8" "78.7" "68.6" "44.0" "91.5" "836.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2735298958942986864" "False" "Low" "IsMasterProtein" "Q9Y5F7" "Protocadherin gamma-C4 OS=Homo sapiens OX=9606 GN=PCDHGC4 PE=1 SV=1" "0.055" "False" "1.223" "1" "1" "1" "1" "938" "101.2" "5.35" "2.21" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974" "56098" "ENSG00000242419" "PCDHGC4" "hsa:56098; Q495T2; Q9Y5C3; Q9Y5F7" "" "" "0" "0" "0.974" "0.830" "1.047" "0.910" "0.969" "1.054" "0.982" "0.710" "0.651" "215.3" "209.6" "178.7" "225.4" "195.9" "208.6" "226.9" "211.4" "152.8" "140.2" "" "" "" "" "" "" "" "" "" "" "190.9" "173.7" "155.9" "168.5" "163.3" "191.6" "191.8" "174.7" "140.1" "140.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065453246646173554" "False" "Low" "IsMasterProtein" "O15231" "Zinc finger protein 185 OS=Homo sapiens OX=9606 GN=ZNF185 PE=1 SV=3" "0.056" "False" "1.221" "2" "1" "1" "1" "689" "73.5" "7.01" "1.64" "1" "" "cytoskeleton;other cell component" "other molecular function" "" "7739" "ENSG00000147394; ENSG00000292196" "ZNF185" "A4FTV3; A6NME5; B4DLE9; B7Z771; B8K2L9; B8K2M0; B8K2M1; B8K2M2; E9PFR6; F5GXF7; F5GZL4; F8W8V7; H0Y4M8; hsa:7739; O00345; O15231; Q8N1R8; Q9NSD2" "" "" "0" "0" "0.916" "0.862" "0.868" "0.813" "0.744" "0.900" "0.782" "0.919" "0.659" "64.0" "58.6" "55.2" "55.5" "52.0" "47.6" "57.6" "50.0" "58.8" "42.1" "" "" "" "" "" "" "" "" "" "" "56.7" "48.5" "48.1" "41.5" "43.4" "43.7" "48.7" "41.3" "53.9" "42.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4932179275381718129" "False" "Low" "IsMasterProtein" "Q6UY01" "Leucine-rich repeat-containing protein 31 OS=Homo sapiens OX=9606 GN=LRRC31 PE=1 SV=1" "0.057" "False" "1.216" "2" "1" "1" "1" "552" "61.5" "6.02" "0.00" "1" "" "" "" "" "79782" "ENSG00000114248" "LRRC31" "B7ZL44; E5RJA9; hsa:79782; Q17RA3; Q6UY01; Q8N848; Q9H5N5; V9HW14" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890880560088896106" "False" "Low" "IsMasterProtein" "Q8NFZ5" "TNFAIP3-interacting protein 2 OS=Homo sapiens OX=9606 GN=TNIP2 PE=1 SV=1" "0.057" "False" "1.213" "2" "1" "1" "1" "429" "48.7" "6.44" "1.92" "1" "stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12180" "79155" "ENSG00000168884" "TNIP2" "B1AKS4; B3KTY8; D3DVQ9; hsa:79155; Q7L5L2; Q8NFZ5; Q9BQR6; Q9H682" "MAP3K8 (TPL2)-dependent MAPK1/3 activation; Ovarian tumor domain proteases" "RAC1/PAK1/p38/MMP2 pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "531909655796894349" "False" "Low" "IsMasterProtein" "Q8WWQ8" "Stabilin-2 OS=Homo sapiens OX=9606 GN=STAB2 PE=1 SV=3" "0.057" "False" "1.211" "1" "1" "2" "1" "2551" "276.8" "6.40" "2.15" "1" "cell adhesion;other metabolic processes;stress response;transport;developmental processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00193, Pf02469, Pf12947" "55576" "ENSG00000136011" "STAB2" "hsa:55576; Q6ZMK2; Q7Z5N9; Q86UR4; Q8IUG9; Q8TES1; Q8WWQ8; Q9H7H7; Q9NRY3" "Hyaluronan uptake and degradation; Scavenging by Class H Receptors" "" "2" "0" "0.989" "0.591" "1.169" "0.783" "0.672" "0.943" "0.895" "0.950" "0.460" "195.6" "193.4" "115.6" "228.7" "153.0" "131.3" "184.5" "175.1" "185.8" "89.9" "" "" "" "" "" "" "" "" "" "" "173.4" "160.2" "100.9" "171.0" "127.6" "120.6" "155.9" "144.7" "170.4" "89.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2848165254260814565" "False" "Low" "IsMasterProtein" "Q6ZQQ2" "Spermatogenesis-associated protein 31D1 OS=Homo sapiens OX=9606 GN=SPATA31D1 PE=1 SV=1" "0.057" "False" "1.210" "1" "1" "1" "1" "1576" "175.5" "8.85" "2.03" "1" "other biological processes" "other membranes" "" "Pf14650, Pf15371" "389763" "ENSG00000214929" "SPATA31D1" "hsa:389763; Q6ZQQ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6097346577725364269" "False" "Low" "IsMasterProtein" "Q9UJ78" "Zinc finger MYM-type protein 5 OS=Homo sapiens OX=9606 GN=ZMYM5 PE=1 SV=4" "0.059" "False" "1.208" "2" "1" "1" "1" "669" "74.8" "8.16" "0.00" "1" "other biological processes" "nucleus" "other molecular function" "Pf06467" "9205" "ENSG00000132950" "ZMYM5" "B2R6V1; hsa:9205; Q5T6E1; Q5T6E2; Q5T6E4; Q96IY6; Q9NZY5; Q9UBW0; Q9UJ77; Q9UJ78" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "474407883661009109" "False" "Low" "IsMasterProtein" "Q2M2W7" "UPF0450 protein C17orf58 OS=Homo sapiens OX=9606 GN=C17orf58 PE=1 SV=3" "0.059" "False" "1.208" "2" "1" "1" "1" "339" "37.0" "10.40" "2.24" "1" "" "" "" "" "284018" "ENSG00000186665" "C17orf58" "A0A1B0GTI9; A8MQV2; hsa:284018; Q2M2W7" "" "" "0" "0" "0.968" "0.823" "1.019" "0.817" "1.022" "0.904" "1.005" "0.926" "0.916" "122.6" "118.7" "100.9" "124.9" "100.2" "125.3" "110.8" "123.2" "113.5" "112.3" "" "" "" "" "" "" "" "" "" "" "108.7" "98.3" "88.0" "93.4" "83.5" "115.1" "93.7" "101.9" "104.1" "112.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2689761144797840992" "False" "Low" "IsMasterProtein" "Q5T8A7" "Protein phosphatase 1 regulatory subunit 26 OS=Homo sapiens OX=9606 GN=PPP1R26 PE=1 SV=1" "0.059" "False" "1.207" "0" "1" "2" "1" "1209" "127.3" "8.59" "2.98" "1" "" "nucleus" "enzyme regulator activity" "Pf15740" "9858" "ENSG00000196422" "PPP1R26" "hsa:9858; Q5T8A7; Q86WU0; Q8WVV0; Q9Y4D3" "" "" "0" "0" "0.858" "0.774" "0.915" "0.718" "1.171" "0.830" "0.891" "0.934" "0.422" "114.5" "98.3" "88.6" "104.8" "82.1" "134.0" "95.0" "102.0" "106.9" "48.4" "" "" "" "" "" "" "" "" "" "" "101.5" "81.4" "77.3" "78.4" "68.5" "123.1" "80.3" "84.3" "98.0" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7670404762929313903" "False" "Low" "IsMasterProtein" "Q9BYW2" "Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3" "0.059" "False" "1.206" "0" "1" "1" "1" "2564" "287.4" "6.14" "2.21" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00856, Pf08236, Pf17907" "29072" "ENSG00000181555" "SETD2" "hsa:29072; O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0; Q9BYW2; Q9C0D1; Q9H696; Q9NZW9" "PKMTs methylate histone lysines" "Histone modifications; Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Pleural mesothelioma" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479950461840362459" "False" "Low" "IsMasterProtein" "Q0VGL1" "Ragulator complex protein LAMTOR4 OS=Homo sapiens OX=9606 GN=LAMTOR4 PE=1 SV=1" "0.060" "False" "1.201" "7" "1" "1" "1" "99" "10.7" "6.54" "2.67" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "" "389541" "ENSG00000188186" "LAMTOR4" "hsa:389541; Q0VGL1" "Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "" "7" "0" "1.121" "0.981" "1.043" "1.101" "1.091" "1.105" "1.061" "0.928" "1.085" "104.6" "117.3" "102.7" "109.1" "115.2" "114.2" "115.6" "111.0" "97.1" "113.5" "" "" "" "" "" "" "" "" "" "" "92.8" "97.1" "89.6" "81.6" "96.1" "104.9" "97.7" "91.7" "89.0" "113.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3856255283194803531" "False" "Low" "IsMasterProtein" "Q53GG5" "PDZ and LIM domain protein 3 OS=Homo sapiens OX=9606 GN=PDLIM3 PE=1 SV=1" "0.061" "False" "1.198" "5" "1" "1" "1" "364" "39.2" "6.89" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "27295" "ENSG00000154553" "PDLIM3" "B2R866; hsa:27295; O43590; O60439; O60440; Q53GG5; Q8N6Y6; Q9BVP4" "" "" "0" "0" "0.723" "0.771" "0.786" "0.658" "0.744" "0.769" "0.763" "0.757" "0.654" "173.1" "125.2" "133.5" "136.1" "113.9" "128.8" "133.2" "132.1" "131.0" "113.3" "" "" "" "" "" "" "" "" "" "" "153.5" "103.7" "116.5" "101.8" "95.0" "118.3" "112.6" "109.2" "120.2" "113.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3619599461952727215" "False" "Low" "IsMasterProtein" "O00300" "Tumor necrosis factor receptor superfamily member 11B OS=Homo sapiens OX=9606 GN=TNFRSF11B PE=1 SV=3" "0.061" "False" "1.197" "2" "1" "1" "1" "401" "46.0" "8.29" "3.17" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00020, Pf00531" "4982" "ENSG00000164761" "TNFRSF11B" "B2R9A8; hsa:4982; O00300; O60236; Q53FX6; Q9UHP4" "TNFs bind their physiological receptors" "Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Clock-controlled autophagy in bone metabolism; Monoamine transport" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1125859041744935918" "False" "Low" "IsMasterProtein" "Q96HA7" "Tonsoku-like protein OS=Homo sapiens OX=9606 GN=TONSL PE=1 SV=2" "0.061" "False" "1.197" "1" "1" "1" "1" "1378" "150.8" "6.42" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00023, Pf13181, Pf13516" "4796" "ENSG00000160949" "TONSL" "B5MDP0; C9JKB1; C9JNV8; hsa:4796; Q13006; Q96HA7; Q9UGJ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "High" "1" "" "830230831394585801" "False" "Low" "IsMasterProtein" "O43909" "Exostosin-like 3 OS=Homo sapiens OX=9606 GN=EXTL3 PE=1 SV=1" "0.061" "False" "1.195" "1" "1" "1" "1" "919" "104.7" "6.51" "2.76" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf03016, Pf09258" "2137" "ENSG00000012232" "EXTL3" "D3DST8; hsa:2137; O00225; O43909; Q53XT3" "XBP1(S) activates chaperone genes" "Proteoglycan biosynthesis; Glycosaminoglycan synthesis in fibroblasts" "3" "0" "0.932" "0.761" "1.052" "0.700" "1.161" "0.970" "1.033" "0.929" "1.038" "109.0" "101.5" "82.9" "114.6" "76.3" "126.6" "105.7" "112.5" "101.2" "113.1" "" "" "" "" "" "" "" "" "" "" "96.6" "84.1" "72.3" "85.7" "63.6" "116.3" "89.3" "93.0" "92.8" "113.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5316556995515416405" "False" "Low" "IsMasterProtein" "Q6R327" "Rapamycin-insensitive companion of mTOR OS=Homo sapiens OX=9606 GN=RICTOR PE=1 SV=1" "0.061" "False" "1.194" "0" "1" "2" "1" "1708" "192.1" "7.47" "5.52" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf14663, Pf14664, Pf14665, Pf14666, Pf14668" "253260" "ENSG00000164327" "RICTOR" "B2RNX0; B7ZMF7; hsa:253260; Q68DT5; Q6R327; Q86UB7; Q8N3A0; Q8NCM6" "Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability" "Target of rapamycin signaling; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "15" "0" "1.075" "1.048" "1.198" "1.123" "1.091" "1.313" "0.975" "0.876" "0.849" "69.7" "74.9" "73.0" "83.5" "78.2" "76.0" "91.5" "68.0" "61.0" "59.1" "" "" "" "" "" "" "" "" "" "" "61.8" "62.1" "63.7" "62.4" "65.2" "69.9" "77.3" "56.2" "56.0" "59.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4695179923593894895" "False" "Low" "IsMasterProtein" "Q7L0Q8" "Rho-related GTP-binding protein RhoU OS=Homo sapiens OX=9606 GN=RHOU PE=1 SV=1" "0.061" "False" "1.194" "3" "1" "1" "1" "258" "28.2" "8.06" "2.96" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "58480" "ENSG00000116574; ENSG00000284984" "RHOU" "B1AKN1; hsa:58480; Q59FE9; Q7L0Q8; Q8TDQ2" "RHOU GTPase cycle; Interleukin-4 and Interleukin-13 signaling" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321903880921765338" "False" "Low" "IsMasterProtein" "Q7RTU4" "Class A basic helix-loop-helix protein 9 OS=Homo sapiens OX=9606 GN=BHLHA9 PE=1 SV=2" "0.062" "False" "1.192" "3" "1" "1" "1" "235" "24.1" "11.21" "2.43" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "727857" "ENSG00000205899" "BHLHA9" "A8MSH6; hsa:727857; Q7RTU4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470537921174600195" "False" "Low" "IsMasterProtein" "Q9NZM1" "Myoferlin OS=Homo sapiens OX=9606 GN=MYOF PE=1 SV=1" "0.062" "False" "1.191" "0" "1" "1" "1" "2061" "234.6" "6.18" "0.00" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00168, Pf08150, Pf08151, Pf08165, Pf16165" "26509" "ENSG00000138119" "MYOF" "B3KQN5; hsa:26509; Q5VWW2; Q5VWW3; Q5VWW4; Q5VWW5; Q7Z642; Q8IWH0; Q9HBU3; Q9NZM0; Q9NZM1; Q9ULL3; Q9Y4U4" "" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Hepatitis C and hepatocellular carcinoma" "3" "0" "1.227" "0.839" "1.309" "1.048" "1.639" "1.218" "1.293" "1.119" "2.369" "11.4" "14.0" "9.6" "14.9" "11.9" "18.7" "13.9" "14.7" "12.7" "27.0" "" "" "" "" "" "" "" "" "" "" "10.1" "11.6" "8.3" "11.2" "10.0" "17.2" "11.7" "12.2" "11.7" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "Low" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.062" "False" "1.189" "1" "1" "1" "1" "1360" "152.7" "6.90" "0.00" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "8" "0" "1.307" "1.168" "1.423" "1.272" "0.927" "1.154" "1.295" "1.128" "1.240" "48.3" "63.1" "56.4" "68.7" "61.4" "44.8" "55.7" "62.5" "54.5" "59.9" "" "" "" "" "" "" "" "" "" "" "42.8" "52.3" "49.2" "51.4" "51.2" "41.1" "47.1" "51.7" "49.9" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8385719763609438508" "False" "Low" "IsMasterProtein" "Q8N1P7" "Beta/gamma crystallin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CRYBG2 PE=1 SV=2" "0.062" "False" "1.185" "1" "1" "1" "1" "1661" "177.8" "6.05" "2.05" "1" "" "" "other molecular function" "Pf00030, Pf00652" "55057" "ENSG00000176092" "CRYBG2" "B2RNG3; hsa:55057; Q5T137; Q5T150; Q8N1P7" "" "" "0" "0" "0.888" "1.202" "1.087" "0.944" "0.863" "1.101" "0.940" "0.817" "1.010" "224.8" "199.5" "270.2" "244.5" "212.3" "194.0" "247.5" "211.3" "183.7" "227.1" "" "" "" "" "" "" "" "" "" "" "199.3" "165.3" "235.8" "182.8" "177.0" "178.2" "209.2" "174.7" "168.4" "227.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1003623499863129748" "False" "Low" "IsMasterProtein" "Q5VV41" "Rho guanine nucleotide exchange factor 16 OS=Homo sapiens OX=9606 GN=ARHGEF16 PE=1 SV=1" "0.062" "False" "1.184" "2" "1" "1" "1" "709" "80.1" "7.36" "0.00" "1" "other biological processes" "cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00018, Pf00169, Pf00621" "27237" "ENSG00000130762" "ARHGEF16" "hsa:27237; Q5VV41; Q86TF0; Q99434" "CDC42 GTPase cycle; RHOG GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "" "4" "0" "0.858" "0.707" "1.092" "0.924" "0.905" "0.955" "0.825" "1.285" "0.592" "28.5" "24.5" "20.2" "31.2" "26.4" "25.8" "27.3" "23.5" "36.7" "16.9" "" "" "" "" "" "" "" "" "" "" "25.3" "20.3" "17.6" "23.3" "22.0" "23.7" "23.0" "19.5" "33.6" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5110647921577969291" "False" "Low" "IsMasterProtein" "O95139" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFB6 PE=1 SV=3" "0.064" "False" "1.179" "5" "1" "1" "1" "128" "15.5" "9.63" "2.06" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "transporter activity" "Pf09782" "4712" "ENSG00000165264" "NDUFB6" "A8K0Y7; hsa:4712; O95139; Q5VYT2; Q6IB84" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429984818239481220" "False" "Low" "IsMasterProtein" "O60488" "Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2" "0.064" "False" "1.177" "1" "1" "1" "1" "711" "79.1" "8.38" "0.00" "1" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2182" "ENSG00000068366" "ACSL4" "D3DUY2; hsa:2182; O60488; O60848; O60849; Q5JWV8" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "622668771381215143" "False" "Low" "IsMasterProtein" "Q96MC9" "Putative uncharacterized protein IKBKE-AS1 OS=Homo sapiens OX=9606 GN=IKBKE-AS1 PE=5 SV=2" "0.064" "False" "1.174" "4" "1" "1" "1" "270" "29.8" "10.37" "2.20" "1" "" "" "" "" "" "" "IKBKE-AS1" "Q5JTS5; Q96MC9" "" "" "0" "0" "1.115" "1.166" "1.336" "0.975" "0.904" "1.048" "1.105" "0.989" "0.652" "148.2" "165.2" "172.8" "198.1" "144.6" "133.9" "155.3" "163.7" "146.6" "96.6" "" "" "" "" "" "" "" "" "" "" "131.4" "136.9" "150.8" "148.1" "120.5" "123.0" "131.3" "135.3" "134.4" "96.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8155016399758939464" "False" "Low" "IsMasterProtein" "Q9UNS1" "Protein timeless homolog OS=Homo sapiens OX=9606 GN=TIMELESS PE=1 SV=2" "0.064" "False" "1.173" "1" "1" "1" "1" "1208" "138.6" "5.40" "0.00" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04821, Pf05029" "8914" "ENSG00000111602" "TIMELESS" "B2ZAV0; hsa:8914; O94802; Q86VM1; Q8IWH3; Q9UNS1" "Processing of DNA double-strand break ends" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8334226789552737635" "False" "Low" "IsMasterProtein" "P14651" "Homeobox protein Hox-B3 OS=Homo sapiens OX=9606 GN=HOXB3 PE=1 SV=2" "0.065" "False" "1.171" "1" "1" "1" "1" "431" "44.3" "9.17" "0.00" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf13293" "3213" "ENSG00000120093" "HOXB3" "A8K567; B7Z5N8; B7Z5P8; B7ZAD0; D3DTV3; hsa:3213; O95615; P14651; P17484" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7573088116227200486" "False" "Low" "IsMasterProtein" "Q13753" "Laminin subunit gamma-2 OS=Homo sapiens OX=9606 GN=LAMC2 PE=1 SV=2" "0.065" "False" "1.169" "1" "1" "1" "1" "1193" "130.9" "6.19" "2.54" "1" "cell adhesion;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "other molecular function" "Pf00052, Pf00053" "3918" "ENSG00000058085" "LAMC2" "hsa:3918; Q02536; Q02537; Q13752; Q13753; Q14941; Q14DF7; Q2M1N2; Q5VYE8" "Laminin interactions; Anchoring fibril formation; Degradation of the extracellular matrix; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling; Type I hemidesmosome assembly" "Alpha 6 beta 4 signaling pathway; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Pleural mesothelioma" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4670847661285806919" "False" "Low" "IsMasterProtein" "Q8WWT9" "Na(+)/dicarboxylate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC13A3 PE=1 SV=1" "0.065" "False" "1.167" "1" "1" "2" "1" "602" "66.8" "8.32" "5.11" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf00939" "64849" "ENSG00000158296" "SLC13A3" "B4DIR8; E1P5U4; F6WI18; hsa:64849; Q5JYC9; Q5JYD0; Q5JYD1; Q5TCQ2; Q8IVB1; Q8N8K4; Q8WWT9; Q96MM5; Q9BR25; Q9H1G1; Q9H3W4; Q9NQN5; Q9NS04" "Sodium-coupled sulphate, di- and tri-carboxylate transporters" "Proximal tubule transport" "2" "0" "0.874" "1.015" "0.916" "0.715" "0.996" "0.960" "0.981" "0.990" "0.408" "324.6" "283.7" "329.5" "297.2" "231.9" "323.3" "311.7" "318.3" "321.4" "132.3" "" "" "" "" "" "" "" "" "" "" "287.8" "235.0" "287.5" "222.3" "193.4" "297.0" "263.4" "263.1" "294.7" "132.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6608596923630436512" "False" "Low" "IsMasterProtein" "Q96CD0" "F-box/LRR-repeat protein 8 OS=Homo sapiens OX=9606 GN=FBXL8 PE=1 SV=1" "0.065" "False" "1.166" "2" "1" "1" "1" "374" "40.5" "7.31" "2.78" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "55336" "ENSG00000135722" "FBXL8" "hsa:55336; Q96CD0; Q9NUM0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.957" "0.965" "1.040" "1.064" "1.238" "1.288" "1.054" "1.429" "1.015" "62.3" "59.7" "60.2" "64.8" "66.4" "77.2" "80.3" "65.7" "89.1" "63.3" "" "" "" "" "" "" "" "" "" "" "55.3" "49.4" "52.5" "48.5" "55.3" "70.9" "67.9" "54.3" "81.7" "63.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3073317532419455068" "False" "Low" "IsMasterProtein" "Q07954" "Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2" "0.065" "False" "1.166" "0" "1" "1" "1" "4544" "504.3" "5.39" "2.31" "1" "other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670, Pf16472" "4035" "ENSG00000123384" "LRP1" "hsa:4035; Q07954; Q2PP12; Q86SW0; Q8IVG8" "Scavenging of heme from plasma; Retinoid metabolism and transport" "Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Cholesterol metabolism" "11" "0" "0.949" "0.960" "0.921" "0.809" "0.834" "1.110" "0.928" "0.751" "0.420" "71.6" "68.0" "68.8" "66.0" "58.0" "59.7" "79.5" "66.4" "53.8" "30.1" "" "" "" "" "" "" "" "" "" "" "63.5" "56.3" "60.0" "49.3" "48.3" "54.9" "67.2" "54.9" "49.4" "30.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1095568573092082412" "False" "Low" "IsMasterProtein" "Q16762" "Thiosulfate sulfurtransferase OS=Homo sapiens OX=9606 GN=TST PE=1 SV=4" "0.066" "False" "1.163" "4" "1" "1" "1" "297" "33.4" "7.25" "2.21" "1" "other metabolic processes;transport;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00581" "7263" "ENSG00000128311" "TST" "B3KRM1; hsa:7263; Q16762; Q6IB06" "Sulfide oxidation to sulfate" "" "2" "0" "1.013" "0.960" "1.139" "1.033" "0.979" "1.228" "1.172" "0.962" "0.777" "92.4" "93.5" "88.6" "105.2" "95.4" "90.5" "113.4" "108.2" "88.9" "71.7" "" "" "" "" "" "" "" "" "" "" "81.9" "77.5" "77.4" "78.6" "79.6" "83.1" "95.9" "89.5" "81.5" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4471823552801457794" "False" "Low" "IsMasterProtein" "Q9GZN1" "Actin-related protein 6 OS=Homo sapiens OX=9606 GN=ACTR6 PE=1 SV=1" "0.066" "False" "1.162" "2" "1" "1" "1" "396" "45.8" "5.03" "2.45" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00022" "64431" "ENSG00000075089" "ACTR6" "B3KW37; B4DLG9; hsa:64431; Q53GH2; Q9BY39; Q9GZN1; Q9H8H6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6925728381462571283" "False" "Low" "IsMasterProtein" "Q8NET4" "Retrotransposon Gag-like protein 9 OS=Homo sapiens OX=9606 GN=RTL9 PE=1 SV=1" "0.066" "False" "1.161" "1" "1" "1" "1" "1388" "144.2" "6.16" "2.60" "1" "" "" "" "" "57529" "ENSG00000243978" "RTL9" "hsa:57529; Q8NET4; Q9P2M8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8233493505927651107" "False" "Low" "IsMasterProtein" "O94929" "Actin-binding LIM protein 3 OS=Homo sapiens OX=9606 GN=ABLIM3 PE=1 SV=3" "0.066" "False" "1.160" "4" "1" "1" "1" "683" "77.8" "8.54" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf02209, Pf16182" "22885" "ENSG00000173210" "ABLIM3" "A8K121; hsa:22885; O94929; Q19VH3; Q658S1; Q68CI5; Q9BV32" "DCC mediated attractive signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6381027269296732412" "False" "Low" "IsMasterProtein" "Q7Z392" "Trafficking protein particle complex subunit 11 OS=Homo sapiens OX=9606 GN=TRAPPC11 PE=1 SV=2" "0.067" "False" "1.159" "1" "1" "1" "1" "1133" "128.8" "7.14" "2.02" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "" "Pf11817, Pf12742" "60684" "ENSG00000168538" "TRAPPC11" "A4QPB8; B2RCD6; hsa:60684; Q5U5I7; Q6FI73; Q7Z392; Q86T25; Q9H0L1; Q9H5K9; Q9H8Q1; Q9H9I7" "RAB GEFs exchange GTP for GDP on RABs" "Genes related to primary cilium development (based on CRISPR)" "2" "0" "1.252" "0.928" "1.582" "1.306" "0.733" "1.171" "0.871" "0.983" "3.470" "58.8" "73.7" "54.6" "93.1" "76.9" "43.1" "68.9" "51.3" "57.8" "204.1" "" "" "" "" "" "" "" "" "" "" "52.2" "61.0" "47.7" "69.6" "64.1" "39.6" "58.2" "42.4" "53.1" "204.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "876115928982754265" "False" "Low" "IsMasterProtein" "P00519" "Tyrosine-protein kinase ABL1 OS=Homo sapiens OX=9606 GN=ABL1 PE=1 SV=4" "0.067" "False" "1.159" "1" "1" "1" "1" "1130" "122.8" "8.66" "2.63" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714, Pf08919" "25" "ENSG00000097007" "ABL1" "A3KFJ3; hsa:25; P00519; Q13869; Q13870; Q16133; Q17R61; Q45F09" "Factors involved in megakaryocyte development and platelet production; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "30" "0" "0.980" "0.760" "0.808" "0.882" "0.852" "0.835" "0.814" "0.821" "2.041" "110.6" "108.4" "84.0" "89.4" "97.6" "94.2" "92.3" "90.0" "90.8" "225.7" "" "" "" "" "" "" "" "" "" "" "98.1" "89.8" "73.3" "66.9" "81.4" "86.6" "78.0" "74.4" "83.3" "225.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9216636553459193723" "False" "Low" "IsMasterProtein" "Q9HC77" "Centromere protein J OS=Homo sapiens OX=9606 GN=CENPJ PE=1 SV=2" "0.067" "False" "1.158" "1" "1" "1" "1" "1338" "152.9" "6.61" "2.04" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07202" "55835" "ENSG00000151849" "CENPJ" "hsa:55835; Q2KHM6; Q5JPD5; Q5T6R5; Q96KS5; Q9C067; Q9HC77" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1955542657671406465" "False" "Low" "IsMasterProtein" "O95498" "Pantetheine hydrolase VNN2 OS=Homo sapiens OX=9606 GN=VNN2 PE=1 SV=3" "0.067" "False" "1.157" "3" "1" "1" "1" "520" "58.5" "6.52" "0.00" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00795, Pf19018" "8875" "ENSG00000112303" "VNN2" "A0AUZ3; A6NDY1; A8K4E3; A8K7W0; B2DFZ0; B2DFZ1; B2DFZ2; B2DFZ3; F6XL73; hsa:8875; O95498; Q2XUN1; Q9UJF3; Q9UMW2" "Post-translational modification: synthesis of GPI-anchored proteins; Vitamin B5 (pantothenate) metabolism" "" "2" "0" "0.983" "0.705" "1.890" "0.885" "0.874" "1.046" "0.804" "1.058" "0.714" "94.6" "93.0" "66.7" "178.8" "83.7" "82.6" "99.0" "76.0" "100.1" "67.5" "" "" "" "" "" "" "" "" "" "" "83.9" "77.0" "58.2" "133.7" "69.8" "75.9" "83.6" "62.8" "91.8" "67.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1525721856351622471" "False" "Low" "IsMasterProtein" "Q8N6F1" "Claudin-19 OS=Homo sapiens OX=9606 GN=CLDN19 PE=1 SV=2" "0.067" "False" "1.156" "4" "1" "1" "1" "224" "23.2" "8.18" "0.00" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00822" "149461" "ENSG00000164007" "CLDN19" "B7Z5I2; F5H5P9; hsa:149461; Q5QT57; Q8N6F1; Q8N8X0" "Tight junction interactions" "Epithelial to mesenchymal transition in colorectal cancer" "2" "0" "1.342" "0.815" "2.141" "1.302" "0.714" "1.841" "1.232" "1.251" "0.504" "101.5" "136.3" "82.7" "217.4" "132.2" "72.5" "186.9" "125.1" "127.0" "51.2" "" "" "" "" "" "" "" "" "" "" "90.0" "112.9" "72.2" "162.6" "110.2" "66.6" "157.9" "103.4" "116.5" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5237090727857766122" "False" "Low" "IsMasterProtein" "O76054" "SEC14-like protein 2 OS=Homo sapiens OX=9606 GN=SEC14L2 PE=1 SV=1" "0.067" "False" "1.153" "2" "1" "1" "1" "403" "46.1" "7.84" "2.21" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00650, Pf03765" "23541" "ENSG00000100003" "SEC14L2" "B7Z8Q1; F5H3U4; hsa:23541; O76054; Q53EQ2; Q6PD61; Q9ULN4" "" "" "0" "0" "0.929" "0.985" "1.029" "0.954" "0.825" "0.935" "0.728" "1.019" "2.075" "137.2" "127.5" "135.2" "141.2" "130.9" "113.2" "128.3" "99.9" "139.8" "284.7" "" "" "" "" "" "" "" "" "" "" "121.7" "105.6" "118.0" "105.6" "109.2" "103.9" "108.4" "82.6" "128.2" "284.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094806735738830032" "False" "Low" "IsMasterProtein" "O75151" "Lysine-specific demethylase PHF2 OS=Homo sapiens OX=9606 GN=PHF2 PE=1 SV=4" "0.068" "False" "1.149" "1" "1" "1" "1" "1096" "120.7" "9.17" "0.00" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf02373, Pf17811" "5253" "ENSG00000197724" "PHF2" "hsa:5253; O75151; Q4VXG0; Q8N3K2; Q9Y6N4" "HDMs demethylate histones" "" "1" "0" "0.916" "0.674" "0.933" "0.799" "0.796" "0.722" "0.898" "1.381" "0.794" "13.2" "12.1" "8.9" "12.4" "10.6" "10.5" "9.6" "11.9" "18.3" "10.5" "" "" "" "" "" "" "" "" "" "" "11.7" "10.1" "7.8" "9.2" "8.8" "9.7" "8.1" "9.8" "16.8" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4152940501784174244" "False" "Low" "IsMasterProtein" "Q8TF61" "F-box only protein 41 OS=Homo sapiens OX=9606 GN=FBXO41 PE=1 SV=5" "0.068" "False" "1.149" "1" "1" "1" "1" "875" "94.4" "8.24" "2.07" "1" "" "cytosol" "" "Pf12937" "150726" "ENSG00000163013" "FBXO41" "G3V0Z7; hsa:150726; Q2M1V8; Q8TF61" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.879" "1.420" "0.960" "1.141" "0.961" "1.172" "1.389" "1.126" "0.725" "70.6" "62.0" "100.2" "67.8" "80.5" "67.8" "82.7" "98.0" "79.5" "51.2" "" "" "" "" "" "" "" "" "" "" "62.6" "51.4" "87.5" "50.7" "67.2" "62.3" "69.9" "81.0" "72.9" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415250102849728185" "False" "Low" "IsMasterProtein" "Q76FK4" "Nucleolar protein 8 OS=Homo sapiens OX=9606 GN=NOL8 PE=1 SV=1" "0.069" "False" "1.148" "1" "1" "1" "1" "1167" "131.5" "7.09" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "55035" "ENSG00000198000; ENSG00000291347" "NOL8" "hsa:55035; Q5TCC7; Q5TCC8; Q5TCD3; Q5TCD5; Q5TCD6; Q5TCD7; Q76D35; Q76FK4; Q7L3E2; Q9H586; Q9H795; Q9H7W7; Q9H9J6; Q9NWA4; Q9NWM4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-584251936546438698" "False" "Low" "IsMasterProtein" "A6NC86" "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein OS=Homo sapiens OX=9606 GN=PINLYP PE=1 SV=3" "0.068" "False" "1.147" "3" "1" "1" "1" "204" "21.9" "7.99" "2.57" "1" "" "non-structural extracellular" "enzyme regulator activity" "Pf00021, Pf02988" "390940" "ENSG00000234465" "PINLYP" "A6NC86; B7Z457; hsa:390940; O95053" "" "" "0" "0" "0.827" "0.849" "1.002" "0.629" "1.126" "1.020" "1.002" "0.807" "1.161" "284.4" "235.2" "241.6" "284.9" "178.9" "320.4" "290.1" "285.0" "229.5" "330.1" "" "" "" "" "" "" "" "" "" "" "252.2" "194.8" "210.8" "213.1" "149.2" "294.3" "245.2" "235.5" "210.4" "330.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1444375086516268996" "False" "Low" "IsMasterProtein" "Q70Z35" "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Homo sapiens OX=9606 GN=PREX2 PE=1 SV=1" "0.068" "False" "1.146" "1" "1" "1" "1" "1606" "182.5" "7.44" "0.00" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00169, Pf00595, Pf00610, Pf00621" "80243" "ENSG00000046889" "PREX2" "B4DFX0; hsa:80243; Q32KL0; Q32KL1; Q6R7Q3; Q6R7Q4; Q70Z35; Q9H805; Q9H961" "Regulation of PTEN stability and activity; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "Melanoma" "5" "0" "1.778" "1.658" "1.208" "2.207" "1.206" "1.277" "1.498" "1.243" "0.747" "12.7" "22.6" "21.1" "15.4" "28.1" "15.4" "16.3" "19.1" "15.8" "9.5" "" "" "" "" "" "" "" "" "" "" "11.3" "18.8" "18.4" "11.5" "23.4" "14.1" "13.8" "15.8" "14.5" "9.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2707905122165005469" "False" "Low" "IsMasterProtein" "Q8TF44" "C2 calcium-dependent domain-containing protein 4C OS=Homo sapiens OX=9606 GN=C2CD4C PE=1 SV=2" "0.070" "False" "1.140" "2" "1" "1" "1" "421" "44.5" "9.73" "2.60" "1" "" "cytosol" "" "Pf00168" "126567" "ENSG00000183186" "C2CD4C" "hsa:126567; Q8N3H7; Q8TF44" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Low" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.070" "False" "1.140" "1" "1" "1" "1" "1022" "115.1" "7.96" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.027" "0.830" "0.944" "1.046" "1.130" "1.031" "1.128" "0.840" "0.391" "120.4" "123.7" "100.0" "113.6" "125.9" "136.1" "124.2" "135.9" "101.2" "47.1" "" "" "" "" "" "" "" "" "" "" "106.8" "102.4" "87.2" "85.0" "105.0" "125.0" "104.9" "112.3" "92.8" "47.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3498507412283592556" "False" "Low" "IsMasterProtein" "Q99767" "Amyloid-beta A4 precursor protein-binding family A member 2 OS=Homo sapiens OX=9606 GN=APBA2 PE=1 SV=3" "0.070" "False" "1.138" "2" "1" "1" "1" "749" "82.5" "4.86" "0.00" "1" "cell-cell signaling;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00595, Pf00640" "321" "ENSG00000034053; ENSG00000276495" "APBA2" "E9PGI4; hsa:321; O60571; Q5XKC0; Q99767" "Neurexins and neuroligins" "IL-18 signaling pathway; 15q11q13 copy number variation" "3" "0" "1.055" "1.345" "1.061" "1.343" "1.251" "1.207" "1.195" "1.045" "0.520" "115.6" "122.0" "155.5" "122.6" "155.3" "144.6" "139.6" "138.2" "120.8" "60.1" "" "" "" "" "" "" "" "" "" "" "102.5" "101.0" "135.7" "91.7" "129.5" "132.8" "118.0" "114.2" "110.8" "60.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1983556703189803247" "False" "Low" "IsMasterProtein" "Q9Y336" "Sialic acid-binding Ig-like lectin 9 OS=Homo sapiens OX=9606 GN=SIGLEC9 PE=1 SV=2" "0.071" "False" "1.138" "3" "1" "1" "1" "463" "50.1" "7.25" "2.08" "1" "cell adhesion;signal transduction" "plasma membrane;other membranes" "other molecular function" "Pf00047, Pf07686" "27180" "ENSG00000129450" "SIGLEC9" "hsa:27180; Q6GTU4; Q9BYI9; Q9Y336" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "2" "0" "1.026" "0.816" "1.007" "0.889" "0.918" "1.294" "0.826" "0.745" "0.466" "109.1" "111.9" "89.1" "109.8" "97.0" "100.2" "141.1" "90.1" "81.3" "50.8" "" "" "" "" "" "" "" "" "" "" "96.7" "92.7" "77.7" "82.1" "80.9" "92.0" "119.3" "74.5" "74.5" "50.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3097174070073328819" "False" "Low" "IsMasterProtein" "O95452" "Gap junction beta-6 protein OS=Homo sapiens OX=9606 GN=GJB6 PE=1 SV=2" "0.072" "False" "1.132" "2" "1" "1" "1" "261" "30.4" "8.51" "1.89" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;cytoskeletal activity" "Pf00029" "10804" "ENSG00000121742" "GJB6" "B3KQN2; hsa:10804; O95452; Q5Q1H9; Q5Q1I0; Q5Q1I1; Q5T5U0; Q8IUP0" "Gap junction assembly" "Calcium regulation in cardiac cells" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1051872979049561943" "False" "Low" "IsMasterProtein" "Q7Z3H4" "Sterile alpha motif domain-containing protein 7 OS=Homo sapiens OX=9606 GN=SAMD7 PE=1 SV=1" "0.072" "False" "1.130" "3" "1" "1" "1" "446" "49.1" "6.80" "0.00" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf00536" "344658" "ENSG00000187033" "SAMD7" "hsa:344658; Q7Z3H4" "" "" "0" "0" "0.997" "1.010" "1.214" "1.021" "0.963" "1.005" "0.904" "0.880" "1.283" "94.7" "94.3" "95.6" "114.9" "96.6" "91.2" "95.1" "85.6" "83.3" "121.4" "" "" "" "" "" "" "" "" "" "" "83.9" "78.1" "83.4" "86.0" "80.6" "83.8" "80.4" "70.8" "76.4" "121.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6722726084616143117" "False" "Low" "IsMasterProtein" "Q9Y2U5" "Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2" "0.072" "False" "1.129" "1" "1" "1" "1" "619" "69.7" "8.00" "0.00" "1" "other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00564" "10746" "ENSG00000169967" "MAP3K2" "B9EG87; hsa:10746; Q53QL9; Q53S75; Q59GZ6; Q8NC32; Q9NYK3; Q9Y2U5" "" "IL-1 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Pleural mesothelioma" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3722373769506016723" "False" "Low" "IsMasterProtein" "Q53TQ3" "INO80 complex subunit D OS=Homo sapiens OX=9606 GN=INO80D PE=1 SV=3" "0.072" "False" "1.127" "1" "1" "1" "1" "1027" "113.1" "7.78" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf13891" "54891" "ENSG00000114933; ENSG00000283510" "INO80D" "B3KU68; B9EG77; hsa:54891; Q53TQ3; Q6PJC6; Q6PJU1; Q6PKA1; Q9NXD5" "UCH proteinases; DNA Damage Recognition in GG-NER" "Gastric cancer network 1" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7354713298349425858" "False" "Low" "IsMasterProtein" "Q8N1T3" "Unconventional myosin-Ih OS=Homo sapiens OX=9606 GN=MYO1H PE=1 SV=2" "0.072" "False" "1.125" "1" "1" "1" "1" "1032" "119.0" "9.09" "2.27" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf06017" "" "" "MYO1H" "F5H3C6; Q8N1T3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1508097308804950005" "False" "Low" "IsMasterProtein" "Q9NRP2" "COX assembly mitochondrial protein 2 homolog OS=Homo sapiens OX=9606 GN=CMC2 PE=1 SV=1" "0.072" "False" "1.125" "8" "1" "1" "1" "79" "9.5" "7.87" "2.54" "1" "" "mitochondrion" "" "Pf08583" "56942" "ENSG00000103121; ENSG00000291948" "CMC2" "D3DUK6; hsa:56942; Q9NRP2" "Mitochondrial protein import" "" "1" "0" "0.876" "0.761" "0.811" "1.008" "0.992" "0.785" "0.863" "0.922" "0.420" "204.1" "178.8" "155.3" "165.4" "205.7" "202.5" "160.2" "176.0" "188.1" "85.6" "" "" "" "" "" "" "" "" "" "" "181.0" "148.1" "135.5" "123.7" "171.6" "186.0" "135.4" "145.5" "172.5" "85.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7648847178929813829" "False" "Low" "IsMasterProtein" "Q9H1K0" "Rabenosyn-5 OS=Homo sapiens OX=9606 GN=RBSN PE=1 SV=2" "0.076" "False" "1.118" "2" "1" "1" "1" "784" "88.8" "5.50" "3.06" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11464, Pf16601" "64145" "ENSG00000131381" "RBSN" "B4DWY8; C9J4P5; hsa:64145; Q3KP30; Q59EY8; Q8NAQ1; Q9H1K0" "Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade" "" "2" "0" "0.981" "1.034" "1.059" "0.948" "1.127" "1.146" "1.096" "1.038" "0.634" "380.1" "372.8" "392.8" "402.6" "360.5" "428.5" "435.5" "416.5" "394.6" "240.8" "" "" "" "" "" "" "" "" "" "" "337.1" "308.8" "342.8" "301.1" "300.6" "393.7" "368.0" "344.3" "361.9" "240.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "719275751802252942" "False" "Low" "IsMasterProtein" "Q17RQ9" "NTPase KAP family P-loop domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NKPD1 PE=1 SV=1" "0.075" "False" "1.117" "2" "1" "1" "1" "610" "67.7" "8.85" "0.00" "1" "" "other membranes" "" "Pf07693" "" "ENSG00000179846" "NKPD1" "B7ZLG6; D6RH15; Q17RQ9; Q8N2A2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7728541766865700057" "False" "Low" "IsMasterProtein" "Q8TAW3" "Zinc finger protein 671 OS=Homo sapiens OX=9606 GN=ZNF671 PE=1 SV=2" "0.076" "False" "1.114" "2" "1" "1" "1" "534" "60.9" "8.73" "2.04" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "79891" "ENSG00000083814" "ZNF671" "A6NF07; hsa:79891; Q8TAW3; Q9H5E9" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5799699992188837800" "False" "Low" "IsMasterProtein" "Q969X0" "RILP-like protein 2 OS=Homo sapiens OX=9606 GN=RILPL2 PE=1 SV=1" "0.077" "False" "1.114" "3" "1" "1" "1" "211" "24.0" "4.98" "2.51" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf11461" "196383" "ENSG00000150977" "RILPL2" "hsa:196383; Q969X0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1220835464658620030" "False" "Low" "IsMasterProtein" "Q7L2E3" "ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1" "0.077" "False" "1.114" "1" "1" "1" "1" "1194" "133.9" "8.78" "2.08" "1" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf07717, Pf21010" "22907" "ENSG00000132153" "DHX30" "A8K5F1; hsa:22907; O94965; Q7L2E3; Q7Z753; Q96CH4; Q9NUQ0" "" "" "0" "0" "1.713" "0.874" "1.725" "1.132" "1.165" "1.282" "0.964" "0.998" "1.436" "76.9" "131.7" "67.2" "132.6" "87.0" "89.5" "98.5" "74.1" "76.7" "110.4" "" "" "" "" "" "" "" "" "" "" "68.2" "109.1" "58.6" "99.2" "72.6" "82.2" "83.3" "61.2" "70.4" "110.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2920922465256145671" "False" "Low" "IsMasterProtein" "Q08AD1" "Calmodulin-regulated spectrin-associated protein 2 OS=Homo sapiens OX=9606 GN=CAMSAP2 PE=1 SV=3" "0.079" "False" "1.113" "0" "1" "1" "1" "1489" "168.0" "6.80" "2.27" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "23271" "ENSG00000118200" "CAMSAP2" "B1APG6; hsa:23271; Q08AD1; Q08AD2; Q6PGN8; Q96FB3; Q9UG20; Q9UPS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5071844025737464693" "False" "Low" "IsMasterProtein" "O95835" "Serine/threonine-protein kinase LATS1 OS=Homo sapiens OX=9606 GN=LATS1 PE=1 SV=1" "0.079" "False" "1.113" "1" "1" "1" "1" "1130" "126.8" "8.70" "1.69" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf00627" "9113" "ENSG00000131023" "LATS1" "hsa:9113; O95835; Q6PKD0" "Signaling by Hippo" "Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174676453931505858" "False" "Low" "IsMasterProtein" "Cont_Q92764" "Keratin, type I cuticular Ha5 OS=Homo sapiens OX=9606 GN=KRT35 PE=1 SV=5" "0.080" "True" "1.112" "2" "1" "1" "1" "455" "50.3" "4.91" "2.92" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "other molecular function" "Pf00038" "3886" "ENSG00000197079" "KRT35" "hsa:3886; O76012; Q92651; Q92764" "Formation of the cornified envelope" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2322848186288192212" "False" "Low" "IsMasterProtein" "Q6UWS5" "Protein PET117 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=PET117 PE=1 SV=1" "0.080" "False" "1.109" "9" "1" "1" "1" "81" "9.2" "10.10" "3.04" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf15786" "100303755" "ENSG00000232838" "PET117" "hsa:100303755; Q6UWS5" "" "Mitochondrial complex IV assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2727832318638753104" "False" "Low" "IsMasterProtein" "Q9Y4G2" "Pleckstrin homology domain-containing family M member 1 OS=Homo sapiens OX=9606 GN=PLEKHM1 PE=1 SV=3" "0.080" "False" "1.109" "1" "1" "1" "1" "1056" "117.4" "6.52" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02759, Pf13901" "9842" "ENSG00000225190; ENSG00000276358; ENSG00000277111" "PLEKHM1" "hsa:9842; Q6P2R5; Q8TEL9; Q9NPP5; Q9NYA0; Q9Y4G2" "" "Autosomal recessive osteopetrosis pathways; Clock-controlled autophagy in bone metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366471573816439068" "False" "Low" "IsMasterProtein" "P52179" "Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2" "0.080" "False" "1.108" "1" "1" "1" "1" "1685" "187.5" "6.93" "2.73" "1" "developmental processes;signal transduction;other biological processes" "cytoskeleton" "other molecular function" "Pf00041, Pf07679" "8736" "ENSG00000101605" "MYOM1" "hsa:8736; P52179; Q14BD6; Q6H969; Q6ZUU0" "" "Striated muscle contraction pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1540288173630827229" "False" "Low" "IsMasterProtein" "Q15413" "Ryanodine receptor 3 OS=Homo sapiens OX=9606 GN=RYR3 PE=1 SV=3" "0.080" "False" "1.107" "0" "1" "1" "1" "4870" "551.7" "5.68" "3.44" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "transporter activity;other molecular function" "Pf00520, Pf00622, Pf01365, Pf02026, Pf02815, Pf06459, Pf08454, Pf08709, Pf21119" "6263" "ENSG00000198838" "RYR3" "hsa:6263; O15175; Q15412; Q15413" "Stimuli-sensing channels; Ion homeostasis" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Cell-type dependent selectivity of CCK2R signaling; PKC-gamma calcium signaling pathway in ataxia; Alzheimer's disease; Calcium regulation in cardiac cells" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1923674833958402521" "False" "Low" "IsMasterProtein" "Q8N228" "Sex comb on midleg-like protein 4 OS=Homo sapiens OX=9606 GN=SCML4 PE=1 SV=2" "0.080" "False" "1.106" "3" "1" "1" "1" "414" "45.0" "9.74" "2.10" "1" "other biological processes" "nucleus" "other molecular function" "Pf00536, Pf12140, Pf17208" "256380" "ENSG00000146285" "SCML4" "B0QZ10; B0QZ11; B7ZBX3; hsa:256380; Q5JXD0; Q5T0T6; Q8IYY6; Q8N228" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6497684644861067847" "False" "Low" "IsMasterProtein" "Q9Y261" "Hepatocyte nuclear factor 3-beta OS=Homo sapiens OX=9606 GN=FOXA2 PE=1 SV=1" "0.081" "False" "1.106" "2" "1" "1" "1" "457" "48.3" "8.69" "2.58" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf08430, Pf09354" "3170" "ENSG00000125798" "FOXA2" "hsa:3170; Q8WUW4; Q96DF7; Q9Y261" "Formation of axial mesoderm; Formation of definitive endoderm; Regulation of gene expression in beta cells" "Heart development; Cardiac progenitor differentiation; Endoderm differentiation; Dopaminergic neurogenesis; Mesodermal commitment pathway; Ectoderm differentiation; Ectoderm differentiation; 22q11.2 copy number variation syndrome; FOXA2 pathway; Cell lineage map for neuronal differentiation" "13" "0" "0.943" "0.895" "0.954" "0.975" "0.990" "0.917" "0.961" "0.845" "0.526" "628.3" "592.3" "562.5" "599.4" "612.3" "622.1" "576.3" "604.0" "531.1" "330.5" "" "" "" "" "" "" "" "" "" "" "557.2" "490.7" "490.8" "448.3" "510.6" "571.5" "487.1" "499.3" "487.1" "330.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1571197896642046491" "False" "Low" "IsMasterProtein" "P37173" "TGF-beta receptor type-2 OS=Homo sapiens OX=9606 GN=TGFBR2 PE=1 SV=2" "0.081" "False" "1.100" "2" "1" "1" "1" "567" "64.5" "5.90" "3.22" "1" "cell adhesion;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf07714, Pf08917" "7048" "ENSG00000163513" "TGFBR2" "B4DTV5; hsa:7048; P37173; Q15580; Q6DKT6; Q99474" "UCH proteinases; Downregulation of TGF-beta receptor signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer" "Extracellular vesicle-mediated signaling in recipient cells; Nuclear receptors meta-pathway; NRF2 pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; LDLRAD4 and what we know about it; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Primary ovarian insufficiency; TGF-beta receptor signaling" "28" "0" "0.940" "0.869" "1.015" "1.027" "0.935" "0.983" "1.027" "0.729" "0.481" "400.2" "376.2" "347.8" "406.4" "410.8" "374.0" "393.3" "411.1" "291.9" "192.6" "" "" "" "" "" "" "" "" "" "" "354.9" "311.7" "303.5" "303.9" "342.6" "343.6" "332.4" "339.8" "267.7" "192.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "577633882119320208" "False" "Low" "IsMasterProtein" "Q6ZS46" "Putative uncharacterized protein FLJ45840 OS=Homo sapiens OX=9606 PE=5 SV=2" "0.081" "False" "1.100" "5" "1" "1" "1" "218" "22.1" "10.55" "2.71" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6860806725603036539" "False" "Low" "IsMasterProtein" "Q969L4" "U7 snRNA-associated Sm-like protein LSm10 OS=Homo sapiens OX=9606 GN=LSM10 PE=1 SV=1" "0.081" "False" "1.099" "6" "1" "1" "1" "123" "14.1" "9.25" "2.14" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "84967" "ENSG00000181817" "LSM10" "hsa:84967; Q969L4" "RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4445461103723730342" "False" "Low" "IsMasterProtein" "O43439" "Protein CBFA2T2 OS=Homo sapiens OX=9606 GN=CBFA2T2 PE=1 SV=1" "0.081" "False" "1.098" "1" "1" "1" "1" "604" "67.1" "8.05" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01753, Pf07531, Pf08788" "9139" "ENSG00000078699" "CBFA2T2" "B2RAE6; F8W6D7; hsa:9139; O43439; Q5TGE4; Q5TGE5; Q5TGE6; Q5TGE7; Q8IWF3; Q96B06; Q96L00; Q9H436; Q9UJP8; Q9UJP9; Q9UP24" "Specification of primordial germ cells" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329541297808121166" "False" "Low" "IsMasterProtein" "P49848" "Transcription initiation factor TFIID subunit 6 OS=Homo sapiens OX=9606 GN=TAF6 PE=1 SV=1" "0.081" "False" "1.097" "1" "1" "1" "1" "677" "72.6" "8.60" "2.65" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "6878" "ENSG00000106290" "TAF6" "A4D2B2; A4D2B3; B4DT11; D6W5U2; hsa:6878; P49848; Q6AI29" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "Eukaryotic transcription initiation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5820747965278093086" "False" "Low" "IsMasterProtein" "Q9BPX7" "UPF0415 protein C7orf25 OS=Homo sapiens OX=9606 GN=C7orf25 PE=1 SV=1" "0.081" "False" "1.096" "2" "1" "1" "1" "421" "46.4" "6.42" "1.91" "1" "" "" "" "Pf07000, Pf18474" "79020" "ENSG00000136197" "C7orf25" "A4D1V2; hsa:79020; J3KR36; Q9BPX7; Q9H779" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4958676777717570828" "False" "Low" "IsMasterProtein" "Q69YZ2" "Transmembrane protein 200B OS=Homo sapiens OX=9606 GN=TMEM200B PE=1 SV=1" "0.083" "False" "1.092" "4" "1" "1" "1" "307" "32.7" "11.44" "2.24" "1" "" "other membranes" "" "Pf10177" "399474" "ENSG00000253304" "TMEM200B" "hsa:399474; Q69YZ2; Q6P2G8; Q6P2Q5" "" "" "0" "0" "1.030" "0.870" "1.085" "0.904" "0.972" "1.115" "1.107" "0.935" "0.582" "161.8" "166.7" "140.8" "175.7" "146.3" "157.3" "180.4" "179.2" "151.4" "94.1" "" "" "" "" "" "" "" "" "" "" "143.5" "138.1" "122.8" "131.4" "122.0" "144.5" "152.5" "148.2" "138.8" "94.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7207893226396138372" "False" "Low" "IsMasterProtein" "Q5VIY5" "Zinc finger protein 468 OS=Homo sapiens OX=9606 GN=ZNF468 PE=1 SV=1" "0.083" "False" "1.091" "2" "1" "1" "1" "522" "60.5" "8.82" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13465" "90333" "ENSG00000204604" "ZNF468" "A8MV20; hsa:90333; Q5CZB8; Q5VIY4; Q5VIY5; Q68DI7" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8627532811274470679" "False" "Low" "IsMasterProtein" "Q96RD9" "Fc receptor-like protein 5 OS=Homo sapiens OX=9606 GN=FCRL5 PE=1 SV=3" "0.083" "False" "1.091" "1" "1" "1" "1" "977" "106.4" "7.14" "1.80" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf13895" "83416" "ENSG00000143297" "FCRL5" "A0N0M2; B7WNT9; B7WP94; hsa:83416; Q495Q2; Q495Q4; Q5VYK9; Q6UY46; Q96RD9" "" "Extrafollicular and follicular B cell activation by SARS-CoV-2" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5984006583607324295" "False" "Low" "IsMasterProtein" "P50553" "Achaete-scute homolog 1 OS=Homo sapiens OX=9606 GN=ASCL1 PE=1 SV=2" "0.084" "False" "1.087" "4" "1" "1" "1" "236" "25.4" "8.79" "2.95" "1" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "429" "ENSG00000139352" "ASCL1" "A8K3C4; hsa:429; P50553; Q9BQ30" "NGF-stimulated transcription" "Neural crest differentiation; Dopaminergic neurogenesis; Kallmann syndrome; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""